News and Publications


Publication

Published:
Mar 26, 2019

The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells

• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation

Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468

Publication

Published:
6 Feb 2019

KOnezumi: a web application for automating gene disruption strategies to generate knockout mice

A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.

Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090

Publication

Published:
3 Jan 2019

Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche

[Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche]

• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis

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Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013

Award Notification

Published:
27 July 2018

Award Presented at 2018 ISS Conference, San Fransisco, USA, for "Compelling Results in Biology and Medicine from mouse research and breeding experiments conducted aboard the International Space Station (ISS)"

Award Presented at 2018 ISS Conference, San Fransisco, USA, for “Compelling Results in Biology and Medicine:Transcriptome analysis of gravitational effects on muscles of mice”, from mouse research and breeding experiments conducted aboard the International Space Station (ISS)

More details –> (Link information in Japanese only)

New Publication

Published:
12 July 2018

Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain

• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators

Cell Reports DOI: 10.1016/j.kint.2018.02.025
   (External Link - English)

Event

Published:
26 June 2018

TMRC Seminar - Harry Perkins Institute of Medical Research Associate Professor Kevin Pfleger

Associate Professor Kevin Pfleger Profiling of Receptor Molecule Pharmacology Innovation and Entrepreneurship in Translating Biomedical Research (Presented in English)

Date: July 13th, 2018 (Friday) 17:00-18:15

Place: Innovation Building, Ground Floor, Room 105 #  

Symposium Poster (241 kB PDF)