The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells
• Phf6 deficiency augments HSC self-renewal and confers resistance against the TNFα-mediated growth inhibition on HSCs
• Phf6 deficiency alone is not sufficient to induce hematopoietic transformation
→ Blood 2019 :blood.2019000468; doi: https://doi.org/10.1182/blood.2019000468
KOnezumi: a web application for automating gene disruption strategies to generate knockout mice
A simple and user-friendly web application for use in automating the design of knockout strategies for multiple genes is proposed.
→ Bioinformatics, btz090, https://doi.org/10.1093/bioinformatics/btz090
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche
[Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche]
• Mouse spermatogenic stem cells (SSCs) migrate among their differentiating progeny
• Lymphatic endothelial cells near vasculature secrete FGFs that act as SSC mitogens
• SSCs tune their self-renewal and differentiation in response to FGF consumption
• Competition for limited supply of mitogen (FGFs) regulates SSC density homeostasis
Cell Stem Cell. 2018 Dec 11. pii: S1934-5909(18)30549-6. doi: 10.1016/j.stem.2018.11.013
Award Presented at 2018 ISS Conference, San Fransisco, USA, for “Compelling Results in Biology and Medicine:Transcriptome analysis of gravitational effects on muscles of mice”, from mouse research and breeding experiments conducted aboard the International Space Station (ISS)
More details –> (Link information in Japanese only)
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators
→ Cell Reports DOI: 10.1016/j.kint.2018.02.025
(External Link - English)
TMRC Seminar - Harry Perkins Institute of Medical Research Associate Professor Kevin Pfleger
Associate Professor Kevin Pfleger Profiling of Receptor Molecule Pharmacology Innovation and Entrepreneurship in Translating Biomedical Research (Presented in English)
Date: July 13th, 2018 (Friday) 17:00-18:15
Place: Innovation Building, Ground Floor, Room 105 #