筑波大学 医学医療系 生命医科学域

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神経生理学 Neurophysiology
〜脳による生体の恒常性維持機構の解明に挑む〜
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研究業績
 
✓原著論文
  • Nakamagoe K, Matsumoto S, Touno N, Tateno I, Koganezawa T Saccadic oscillations as a biomarker of clinical symptoms in amyotrophic lateral sclerosis. Neurol Sci. 2023, 44(8), 2787-2793 (PubMed)
  • Nakamagoe K, Yamada S, Kawakami R, Maeno T, Koganezawa T, Tamaoka A  Clinical Application of the Vestibular Stimulation Effect on Balance Disorders with Dementia. Curr Alzheimer Res., 2021, 18(1), 1-7 (PubMed)
  • Aizawa S, Okada T, Keino-Masu K, Doan TH, Koganezawa T, Akiyama M, Tamaoka A, Masu M. Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2. Front Mol Neurosci. 2020, 12, 333 (PubMed) (筑波大学website)(プレスリリース)
  • Mayers T, Gor V, Endo Y, Manda CM, Andrea CS, Taniguchi Y, Changarathil G, Koganezawa T Student voices in scientific English education: A report on the Tsukuba Scientific English Conference 2019 J Med English Educ, 2020, 19(1), 21-26
  • Nakamagoe K, Yamada S, Kawakami RKoganezawa T, Tamaoka A. Abnormal Saccadic Intrusions with Alzheimer's Disease in Darkness. Curr Alzheimer Res. 2019, 16(4), 293-301 (PubMed)
  • Nakamagoe K, Yamada S, Kawakami R, Miyake Z, Tozaka N, Okune S, Takeda H, Koganezawa T, Tamaoka A. Vestibular dysfunction as cortical damage with amyotrophic lateral sclerosis. J Neurol Sci. 2019, 397, 4-8. (PubMed
  • Nakamagoe K, Tozaka N, Nohara S, Kawakami R, Yamada SKoganezawa T, Tamaoka A Upbeat nystagmus is a useful sign in the regional diagnosis of trigeminal nerve disorder with multiple sclerosis. Mult Scler Relat Disord. 2018, 19, 59-61. (PubMed)
  • Nakamagoe K, Nohara S, Takahashi Y, Takiguchi M, Kawakami RKoganezawa T, Tamaoka A  The Successful Application of Plasmapheresis in the Treatment of a Patient with Opsoclonus and Autoantibodies to Glutamate Receptor δ2. Intern Med. 2017, 56(20), 2773-2778. (PubMed)
  • Nakamagoe K, Kadono K, Koganezawa T, Takiguchi M, Terada M, Yamamoto A, Moriyama T, Yanagiha K, Nohara S, Tozaka N, Miyake Z, Aizawa S, Furusho K, Tamaoka A  Vestibular impairment in frontotemporal dementia syndrome. Dement Geriatr Cogn Disord Extra. 2016, 6(2),194-204 (PubMed)
  • Nakamagoe K, Fujimiya S, Koganezawa T, Kadono K, Shimizu K, Fujitsuka N, Takiguchi S, Ueno T, Monzen T, Tamaoka A  Vestibular Function Impairment in Alzheimer’s Disease. J Alzheimers Dis. 2015, 47(1), 185-96 (PubMed)
  • Koganezawa T, Paton JFR Intrinsic chemosensitivity of rostral ventrolateral medullary sympathetic premotor neurons in the in situ arterially perfused preparation of rats. Exp Physiol. 2014, 99(11), 1453-66 (PubMed)
  • Nakamagoe K, Fujitsuka N, Koganezawa T, Yamaguchi T, Tamaoka A Downbeat nystagmus associated with damage to the medial longitudinal fasciculus of the pons: A vestibular balance control mechanism via the lower brainstem paramedian tract neurons. J Neurol Sci. 2013, 328(1-2), 98-101 (PubMed)
  • Nakamagoe K, Fujitsuka N, Koganezawa T, Shimizu K, Takiguchi S, Horaguchi T, Ishii K, Tamaoka A Residual central nervous system damage due to organoarsenic poisoning. Neurotoxicol Teratol. 2013, 37, 33-38 (PubMed)
  • Sabino-Silva R, Ceroni A, Koganezawa T, Michelini LC, Machado UF, Antunes VR  Baroreceptor-mediated activation of sympathetic nerve activity to salivary glands. Physiol Behav, 2012, 107(3), 390-396 (PubMed)
  • Nakamagoe K, Shimizu K, Koganezawa T, Tamaoka A Downbeat nystagmus due to a paramedian medullary lesion. J Clin Neurosci. 2012, 19(11), 1597-9 (PubMed)
  • Nakamagoe K, Mamada N, Shiigai M, Shimizu K, Koganezawa T, Tamaoka A Recurrent isolated abducens nerve paresis associated with persistent trigeminal artery variant. Intern Med. 2012, 51(16), 2213-6 (PubMed)
  • Koganezawa T, Okada Y, Terui N, Paton JFR, Oku Y A μ-opioid receptor agonist DAMGO induces rapid breathing in the arterially perfused in situ preparation of rat. Respir Physiol Neurobiol, 2011, 177(2), 207-11 (PubMed)
  • Koganezawa T, Shimomura Y, Terui N. The viscerosympathetic response in rabbits is mediated by GABAergic and glutamatergic inputs into the sympathetic premotor neurons of the rostral ventrolateral medulla. Exp Physiol. 2010, 95(11), 1061-70 (PubMed)
  • Wang R, Koganezawa T, Terui N. Different responses of symapthetic premotor neurons in the rostral ventrolateral medulla to stimulation of the dorsomedial hypothalamus in rabbits. Brain Res, 2010, 1356, 44-53 (PubMed)
  • Nishimaru H, Koganezawa T, Kakizaki M, Ebihara T, Yanagawa Y. Inhibitory synaptic modulation of Renshaw cell activity in the lumbar spinal cord of neonatal mice. J Neurophysiol, 2010, 103(6), 3437-47 (PubMed)
  • Koganezawa T, Shimomura Y, Teuri N. The role of the RVLM neurons in the viscero-sympathetic reflex: A mini review. Auton Neurosci, 2008, 142(1-2), 17-9 (PubMed)
  • Koganezawa T, Ishikawa T, Fujita Y, Yamashita T, Tajima T, Honda M, Nakayama K. Local regulation of skin blood flow during cooling involving presynaptic P2 purinoceptors in rats. Br J Pharmacol. 2006, 148(5), 579-86. (PubMed)
  • Koganezawa T, Terui N. Reticulospinal neurons inactivated by warming of the preoptic area and anterior hypothalamus of rabbits. Brain Res. 2005, 1061(1), 13-26 (PubMed)
  • Ootsuka Y, Rong W, Kishi E, Koganezawa T, Terui N. Rhythmic activities of the sympatho-excitatory neurons in the medulla of rabbits: neurons controlling cutaneous vasomotion. Auton Neurosci. 2002, 101(1-2), 48-59. (PubMed)
✓最近の学会発表
  • 佐藤優真小金澤禎史 外側手綱核の興奮による心血管応答生成における腹側被蓋野の関与 第50回自律神経生理研究会, 2023, 名古屋
  • 水上璃子小金澤禎史 外側手綱核誘発性のストレス性呼吸応答に対するドーパミン系の関与 第50回自律神経生理研究会, 2023, 名古屋
  • 小金澤禎史 呼吸運動の神経性調節における脳内硫化水素合成酵素の機能解析 第49回日本応用酵素協会研究発表会, 2023, 大阪 (招待講演)
  • Okazaki M, Koganezawa T Endogenous hydrogen sulfide in the medullary respiratory center stabilizes the frequency and power of respiration in a regionally distinct way. Society for Neuroscience 52nd Annual Meeting, 2023, Washington DC (USA)
  • Sato Y, Matsumoto M, Koganezawa T Midbrain dopaminergic areas mediate the stress-induced cardiovascular response caused by activating the lateral habenula. Tsukuba Conference 2023, 2023, Tsukuba (Japan) ("Excellent Poster Awards")
  • Okazaki M, Koganezawa T Hydrogen sulfide in the medullary respiratory center facilitates excitatory synaptic transmission to maintain eupnea. Tsukuba Conference 2023, 2023, Tsukuba (Japan) ("Excellent Poster Awards")
  • Mizukami R, Matsumoto M, Koganezawa T Electrical stimulation of the lateral habenula induces stress-like respiratory responses via the monoamine system in rats. Tsukuba Conference 2023, 2023, Tsukuba (Japan) ("Excellent Poster Awards")
  • Yamada Y, Koganezawa T Hydrogen sulfide synthesized in the rostral ventrolateral medulla modulates the respiratory activity of sympathetic premotor neurons of rats. Tsukuba Conference 2023, 2023, Tsukuba (Japan)
  • Sato Y, Matsumoto M, Koganezawa T Involvement of the midbrain dopaminergic area in the stress-related cardiovascular response induced by the activation of the lateral habenula. The 46th Annual Meeting of the Japan Neuroscience Society, 2023, Sendai (Japan)
  • Okazaki M, Koganezawa T Investigating the functions of endogenous hydrogen sulfide in the medullary respiratory center via modulating excitatory synaptic transmission. The 46th Annual Meeting of the Japan Neuroscience Society, 2023, Sendai (Japan)
  • Mizukami R, Matsumoto M, Koganezawa T Activation of the lateral habenula induces stress-related respiratory responses via the dopamine system of rats. The 46th Annual Meeting of the Japan Neuroscience Society, 2023, Sendai (Japan)
  • Yamada Y, Koganezawa T Hydrogen sulfide synthesized in the rostral ventrolateral medulla modulates the tonic activity of sympathetic premotor neurons in an inhibitory way. The 46th Annual Meeting of the Japan Neuroscience Society, 2023, Sendai (Japan)
  • Okazaki M, Koganezawa T Role of hydrogen sulfide in the modulation of inspiratory/expiratory balance in the respiratory center as compared to inhibition of synaptic transmission. The 100th Annual Meeting of The Physiological Society of Japan, 2023, Kyoto (Japan)
  • Mizukami R, Matsumoto M, Koganezawa T Activation of the lateral habenula causes stress-induced respiratory responses in rats. The 100th Annual Meeting of The Physiological Society of Japan, 2023, Kyoto (Japan)
  • 小金澤禎史 脳内硫化水素の呼吸調節における役割 第75回日本自律神経学会総会 (シンポジウム:自律神経系の基礎研究アップデート), 2022, さいたま (招待講演)
  • Koganezawa T Functional roles of endogenous hydrogen sulfide in the respiratory and cardiovascular control systems. The 15th Oxford Conference on Modelling and Control of Breathing (Oxford Conference 2022) (Symposium: Interaction of respiratory and cardiovascular control systems), 2022, Odawara (Japan)(Invited lecture)
 
✓総説等
  • 岡ア実那子小金澤禎史 脳内の硫化水素は正常な呼吸の維持に必須 医学のあゆみ 2021, 279(12,13), 1183-1184
  • Koganezawa T, Terui N. Cardiovascular center in the medulla; it’s functional differentiation. Transworld Research Network Central Mechanisms of Cardiovascular Regulation  2007, 75-82
  • 小金澤禎史、照井直人 自律神経反射:心血管系 文光堂 自律神経機能検査 2007, 43-49
  • 小金澤禎史 消化、栄養と代謝 羊土社 はじめの一歩のイラスト生理学 2007, 139-154
  • 小金澤禎史、照井直人 延髄腹外側部と循環調節 中外医学社 Clinical Neuroscience 2007,  25(4), 405-407
  • 小金澤禎史、照井直人 血圧の神経性調節 (株)メディカルレビュー社 Brain Medical 2005, 17(2): 41-46