筑波大学大学院 人間総合科学研究科 医学系専攻についてご紹介します。

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開催予定のセミナー情報

The 137th WPI-IIIS seminar
Date Tuesday, October 23, 2018
Time 12:00 –13:00
Venue 1F Auditorium, IIIS Building, University of Tsukuba
Speaker Dr. Junko Ohkanda
Academic Assembly, Institute of Agriculture, Shinshu University
Subject Fusicoccin: A Fungal Metabolite that Regulates 14-3-3 Proteins
Summary

Low-molecular-weight agents that disrupt and stabilize protein-protein interactions (PPIs) are highly desirable for elucidating cellular events as well as for pharmaceutical application. However, it remains a difficult challenge to rationally design and develop such molecules due to the highly dynamic interfaces. This presentation will focus on a fungal metabolite called fusicoccin, and describe our recent efforts on designing chemical probes, inhibitors, and stabilizers of 14-3-3-PPIs exploiting this unique natural product.

Click here for more information

Contact International Institute for Integrative Sleep Medicine
Phone 029-853-8080 (ext.8080)
第137回WPI-IIISセミナー
日 時 平成30年10月23日(火) 12:00-13:00
場 所 筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂
演 者 Dr. Junko Ohkanda (大神田淳子先生)
Academic Assembly, Institute of Agriculture, Shinshu University
(信州大学農学部)
演 題 Fusicoccin: A Fungal Metabolite that Regulates 14-3-3 Proteins
要 旨

Low-molecular-weight agents that disrupt and stabilize protein-protein interactions (PPIs) are highly desirable for elucidating cellular events as well as for pharmaceutical application. However, it remains a difficult challenge to rationally design and develop such molecules due to the highly dynamic interfaces. This presentation will focus on a fungal metabolite called fusicoccin, and describe our recent efforts on designing chemical probes, inhibitors, and stabilizers of 14-3-3-PPIs exploiting this unique natural product.

詳細はこちらからもご覧になれます
国際統合睡眠医科学研究機構長 柳沢 正史

問い合わせ 国際統合睡眠医科学研究機構 (内線8080)
10月23日(火)開催:つくばブレインサイエンス・セミナー 第245回
演題タイトル 自閉症様モデル霊長類の発達期神経回路再編成の異常
日 時 10月23日(火)
演 者 佐々木哲也(Tetsuyai Sasaki)先生
筑波大学医学医療系解剖学神経科学
司 会 武井 陽介(Yosuke Takei)
筑波大学医学医療系
Faculty of Medicine, University of Tsukuba
会 場

筑波大学・医学エリア・健康医科学イノベーション棟8階講堂
(バスご利用の方は「追越学生宿舎前」で下車してください)

備 考

詳細についてはTBSAホームページをご覧ください。
つくばブレインサイエンス協会(TBSA)事務局

第33回医学医療系研究発表会
日時 10月25日(木)18:00~
場所 臨床講義室B
演 者

山本 玲子 物質・材料研究機構・教授
銅・銅合金の抗菌特性と迅速化の試み

渋谷 和子 准教授
免疫受容体を標的とした疾患制御

藤澤 康弘 准教授
Deep learningによる皮膚腫瘍AI診断 ~どこまで専門医に迫れるのか?〜

備 考 医学医療系研究発表会は、生命システム医学専攻および疾患制御医学専攻の科目「医学セミナー」の対象の一つとして認められています。
連絡先 医学研究支援(3022)
HBP World Science Leader's Seminar (WSLS) Seminars in Medical Sciences(医学セミナー)
Time and Date 5pm-6pm, 10/29
Speaker Dr. Aristidis Moustakas
(Professor, Dept of Medical Biochemistry and Microbiology, Uppsala University, Sweden)
Title Antagonism or synergy between BMP and TGFβ pathways in cancer
Place Medical Research Building Room #483 Contact person: Dr. Mitsuyasu Kato, Faculty of Medicince (ext.3944)
HBP World Science Leader's Seminar (WSLS) Seminars in Medical Sciences(医学セミナー)
Time and Date 5pm-6pm, 10/30
Speaker Dr. Peter ten Dijke
(Professor, Dept Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands; Professor, Faculty of Medicine, Univ. of Tsukuba)
Title Bone morphogenic protein signalling in human diseases
Place Medical Research Building Room #483 Contact person: Dr. Mitsuyasu Kato, Faculty of Medicince (ext.3944)
The 138th WPI-IIIS seminar
Date Wednesday, October 31, 2018
Time 12:00 –13:00
Venue 1F Auditorium, IIIS Building, University of Tsukuba
Speaker Dr. Tomoyuki Furuyashiki
Division of Pharmacology, Kobe University Graduate School of Medicine
Subject Stress-Induced Prefrontal Remodeling and its Behavioral Consequences
Summary

Stress is a strain of our mental and bodily functions caused by aversive stimuli. Brief and controllable stress promotes adaptive responses for well-being and survival, whereas prolonged or excessive stress often induces emotional and cognitive dysfunctions and can be a risk factor for mental illnesses. Despite its clinical relevance, the biological basis of stress remains elusive. In this seminar, I will introduce our recent findings using social defeat stress in mice, especially about roles of prefrontal remodeling mediated by dopamine and inflammation for stress-induced behavioral changes.

Click here for more information

Contact International Institute for Integrative Sleep Medicine
Phone 029-853-8080 (ext.8080)
第138回WPI-IIISセミナー
日 時 平成30年10月31日(水) 12:00-13:00
場 所 筑波大学 医学系エリア 睡眠医科学研究棟 1F 講堂
演 者 Dr. Tomoyuki Furuyashiki (古屋敷 智之先生)
Division of Pharmacology, Kobe University Graduate School of Medicine
(神戸大学大学院医学研究科)
演 題 Stress-Induced Prefrontal Remodeling and its Behavioral Consequences
要 旨

Stress is a strain of our mental and bodily functions caused by aversive stimuli. Brief and controllable stress promotes adaptive responses for well-being and survival, whereas prolonged or excessive stress often induces emotional and cognitive dysfunctions and can be a risk factor for mental illnesses. Despite its clinical relevance, the biological basis of stress remains elusive. In this seminar, I will introduce our recent findings using social defeat stress in mice, especially about roles of prefrontal remodeling mediated by dopamine and inflammation for stress-induced behavioral changes.

詳細はこちらからもご覧になれます

問い合わせ 国際統合睡眠医科学研究機構 (内線8080)
医学セミナー・第18回分子遺伝疫学セミナー
"Seminars in Medical Sciences" Lecture
Title Whole-genome sequencing and mutational landscape in cancer genomes
Speaker Dr. Akihiro Fujimoto (Associate Professor, Department of Drug Discovery Medicine, Graduate School of Medicine, Kyoto University)
藤本明洋博士、京都大学大学院医学研究科創薬医学講座 特定准教授
Date November 1, 2018 (Thurs)
Time 17:00-18:15
Venue Faculty of Medicine Building, Room 483 (医学系学系棟483)
Note

This seminar is one of the seminars for the subject "Seminar in Medical Sciences" in Doctoral Programs in Biomedical Sciences and Clinical Sciences.
The seminar will be given in English, but questions in Japanese are also welcome.

This seminar will NOT be video-recorded. Be sure to attend if interested.

Abstract

Next generation sequencing technologies enable us to analyze the mutational landscape in cancer genomes. To identify somatic mutation in liver cancer, we constructed an analysis pipeline for mutation detection. Using the method, we analyzed whole genome sequencing of liver cancer genomes. Our comprehensive analysis identified point mutations, structural variations (STVs), and virus integrations, in noncoding and coding regions. We discovered recurrently mutated coding and noncoding regions, promoters, and regulatory regions. STV analysis found a significant association with replication timing and identified known (CDKN2A, and TERT) and new (ASH1L, and MACROD2) cancer-related genes.

We next focused on mutations in microsatellite regions. Microsatellites are repeats of 1-6bp units and have been used to detect cancers with mismatch repair deficiency. To detect somatic indels in microsatellite regions, we analyzed ~9 million microsatellites in 2,717 cancer samples across 21 tissue types. Our analysis identified samples with higher microsatellite mutation rate (MSI; microsatellite instability). We found 20 highly-mutated microsatellites which can be used to detect MSI cancers with high sensitivity. Analysis of highly mutated microsatellite found that replication timing and DNA shape were significantly associated with mutation rates. Our analysis reveals possible causes of mutations, as well as provides a useful marker set for MSI detection.

contact Naoyuki Tsuchiya, Molecular and Genetic Epidemiology Laboratory / Mail
ヘルスサービスリサーチセミナー
「在宅死等への適切な対処能力習得に向けて」
日時 12月20日(木) 13時45分~15 時
会場 医科学棟 204 室
演題 「死亡診断と死体検案」
講師 岡山大学大学院医歯薬学総合研究科法医学分野
教授 宮石智先生
事務担当 筑波大学 ヘルスサービス開発研究センター(田宮研究室) 森田 千代 / Mail