筑波大学基礎医学系薬理研究室

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Recent publications 近年の主な発表論文

2007

Minami K, Uezono Y, Sakurai T, Horishita T, Shiraishi M, Ueta Y.  
Effects of Anesthetics on the Function of Orexin-1 Receptors Expressed in Xenopus Oocytes.
Pharmacology. 2007 Apr 13;79(4):236-242 [Epub ahead of print]
PMID: 17435392 [PubMed - as supplied by publisher]

 

Zhang S, Zeitzer JM, Sakurai T, Nishino S, Mignot E.
Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy.
J Physiol. 2007 Mar 22; [Epub ahead of print]
PMID: 17379635 [PubMed - as supplied by publisher]
 

 

Sakurai T.
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness.
Nat Rev Neurosci. 2007 Mar;8(3):171-81. Epub 2007 Feb 14.
PMID: 17299454 [PubMed - in process]

2006
Sakurai T.
Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis.
CNS Neurol Disord Drug Targets. 2006 Jun;5(3):313-25. Review.

Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams SC, Yanagisawa M, Sakurai T.
Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain.
Brain Res. 2006 May 12; [Epub ahead of print]
PMID: 16697979 [PubMed - as supplied by publisher]

Takayasu S, Sakurai T, Iwasaki S, Teranishi H, Yamanaka A, Williams SC, Iguchi H, Kawasawa YI, Ikeda Y, Sakakibara I, Ohno K, Ioka RX, Murakami S, Dohmae N, Xie J, Suda T, Motoike T, Ohuchi T, Yanagisawa M, Sakai J.
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice.
Proc Natl Acad Sci U S A. 2006 Apr 28; [Epub ahead of print]
PMID: 16648250 [PubMed - as supplied by publisher]

Xie X, Crowder TL, Yamanaka A, Morairty SR, Lewinter RD, Sakurai T, Kilduff TS.
GABAB receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus.
J Physiol. 2006 Apr 20; [Epub ahead of print]
PMID: 16627567 [PubMed - as supplied by publisher]

Fujiki N, Yoshida Y, Zhang S, Sakurai T, Yanagisawa M, Nishino S.
Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models.
Peptides. 2006 Apr 18; [Epub ahead of print]
PMID: 16626839 [PubMed - as supplied by publisher]

Yamanaka A, Muraki Y, Ichiki K, Tsujino N, Kilduff TS, Goto K, Sakurai T.
Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner.
J Neurophysiol. 2006 Apr 12; [Epub ahead of print]
PMID: 16611835 [PubMed - as supplied by publisher]

Mochizuki T, Klerman EB, Sakurai T, Scammell TE.
Elevated body temperature during sleep in orexin knockout mice.
Am J Physiol Regul Integr Comp Physiol. 2006 Mar 23; [Epub ahead of print]
PMID: 16556901 [PubMed - as supplied by publisher]

Nakamachi T, Matsuda K, Maruyama K, Miura T, Uchiyama M, Funahashi H, Sakurai T, Shioda S.
Regulation by orexin of feeding behaviour and locomotor activity in the goldfish.
J Neuroendocrinol. 2006 Apr;18(4):290-7.
PMID: 16503924 [PubMed - in process]

Yamada T, Ohtani S, Sakurai T, Tsuji T, Kunieda T, Yanagisawa M.
Reduced expression of endothelin receptor type B gene in piebald mice caused by an insertion of a retroposon-like element in intron 1.
J Biol Chem. 2006 Feb 24; [Epub ahead of print]
PMID: 16500897 [PubMed - as supplied by publisher]

Toshinai K, Yamaguchi H, Sun Y, Smith RG, Yamanaka A, Sakurai T, Date Y, Mondal MS, Shimbara T, Kawagoe T, Murakami N, Miyazato M, Kangawa K, Nakazato M.
Des-acyl Ghrelin Induces Food Intake by a Mechanism Independent of the Growth Hormone Secretagogue Receptor.
Endocrinology. 2006 Feb 16; [Epub ahead of print]
PMID: 16484324 [PubMed - as supplied by publisher]

Zhang W, Sakurai T, Fukuda Y, Kuwaki T.
Orexin neuron-mediated skeletal muscle vasodilation and shift of baroreflex during defense response in mice.
Am J Physiol Regul Integr Comp Physiol. 2006 Jan 12; [Epub ahead of print]
PMID: 16410401 [PubMed - as supplied by publisher]

Narita M, Nagumo Y, Hashimoto S, Narita M, Khotib J, Miyatake M, Sakurai T, Yanagisawa M, Nakamachi T, Shioda S, Suzuki T.
Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine.
J Neurosci. 2006 Jan 11;26(2):398-405.
PMID: 16407535 [PubMed - in process]

Yanagita M, Okuda T, Endo S, Tanaka M, Takahashi K, Sugiyama F, Kunita S, Takahashi S, Fukatsu A, Yanagisawa M, Kita T, Sakurai T.
Uterine sensitization-associated gene-1 (USAG-1), a novel BMP antagonist expressed in the kidney, accelerates tubular injury.
J Clin Invest. 2006 Jan 4;116(1):70-79. Epub 2005 Dec 8.
PMID: 16341262 [PubMed - as supplied by publisher]
2005

Tsujino N, Yamanaka A, Ichiki K, Muraki Y, Kilduff TS, Yagami K, Takahashi S, Goto K, Sakurai T.
Cholecystokinin Activates Orexin/Hypocretin Neurons through the Cholecystokinin A Receptor.
J Neurosci. 2005 Aug 10;25(32):7459-7469.
PMID: 16093397 [PubMed - as supplied by publisher]

Meerabux J, Iwayama Y, Sakurai T, Ohba H, Toyota T, Yamada K, Nagata R, Irukayama-Tomobe Y, Shimizu H, Yoshitsugu K, Ohta K, Yoshikawa T.
Association of An Orexin 1 Receptor 408(Val) Variant with Polydipsia-Hyponatremia in Schizophrenic Subjects.
Biol Psychiatry. 2005 Jun 22; [Epub ahead of print]
PMID: 15978554 [PubMed - as supplied by publisher]
Ikeda Y, Iguchi H, Nakata M, Ioka RX, Tanaka T, Iwasaki S, Magoori K, Takayasu S, Yamamoto TT, Kodama T, Yada T, Sakurai T, Yanagisawa M, Sakai J.
Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.
Biochem Biophys Res Commun. 2005 Jun 17; [Epub ahead of print]
PMID: 15967412 [PubMed - as supplied by publisher]
Sakurai T.
Roles of orexin/hypocretin in regulation of sleep/wakefulness and energy homeostasis.
Sleep Med Rev. 2005 Jun 13; [Epub ahead of print]
PMID: 15961331 [PubMed - as supplied by publisher]
Crocker A, Espana RA, Papadopoulou M, Saper CB, Faraco J, Sakurai T, Honda M, Mignot E, Scammell TE.
Concomitant loss of dynorphin, NARP, and orexin in narcolepsy.
Neurology. 2005 Jun 15; [Epub ahead of print]
PMID: 15958752 [PubMed - as supplied by publisher]
Hara J, Yanagisawa M, Sakurai T.
Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions.
Neurosci Lett. 2005 Jun 3;380(3):239-42. Epub 2005 Feb 8.
Sakurai T, Nagata R, Yamanaka A, Kawamura H, Tsujino N, Muraki Y, Kageyama H, Kunita S, Takahashi S, Goto K, Koyama Y, Shioda S, Yanagisawa M.
Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice.
Neuron. 2005 Apr 21;46(2):297-308.
Sakurai T.
Reverse pharmacology of orexin: from an orphan GPCR to integrative physiology.
Regul Pept. 2005 Mar 15;126(1-2):3-10.
PMID: 15620407 [PubMed - in process]
2005 2004 2003 2002 2001 2000 1999 1998
2004
Winsky-Sommerer R, Yamanaka A, Diano S, Borok E, Roberts AJ, Sakurai T, Kilduff TS, Horvath TL, de Lecea L.
Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response.
J Neurosci. 2004 Dec 15;24(50):11439-48.
PMID: 15601950 [PubMed - in process]
Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T, Shibata S.
Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice.
Eur J Neurosci. 2004 Dec;20(11):3054-62.
PMID: 15579160 [PubMed - in process]
Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T, Yanagisawa M.
Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness.
J Neurosci. 2004 Nov 17;24(46):10493-501.
PMID: 15548664 [PubMed - in process]
Muraki Y, Yamanaka A, Tsujino N, Kilduff TS, Goto K, Sakurai T.
Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor.
J Neurosci. 2004 Aug 11;24(32):7159-66.
PMID: 15306649 [PubMed - in process]
Thompson MD, Comings DE, Abu-Ghazalah R, Jereseh Y, Lin L, Wade J, Sakurai T, Tokita S, Yoshida T, Tanaka H, Yanagisawa M, Burnham WM, Moldofsky H.
Variants of the orexin2/hcrt2 receptor gene identified in patients with excessive daytime sleepiness and patients with Tourette's syndrome comorbidity.
Am J Med Genet. 2004 Aug 15;129B(1):69-75.
PMID: 15274044 [PubMed - as supplied by publisher]
Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE.
Behavioral state instability in orexin knock-out mice.
J Neurosci. 2004 Jul 14;24(28):6291-300.
PMID: 15254084 [PubMed - in process]
Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M.
Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat.
J Neurosci. 2004 May 5;24(18):4469-77.
PMID: 15128861
Mieda M, Willie JT, Hara J, Sinton CM, Sakurai T, Yanagisawa M.
Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice.
Proc Natl Acad Sci U S A. 2004 Mar 16
PMID: 15026574
Muroya S, Funahashi H, Yamanaka A, Kohno D, Uramura K, Nambu T, Shibahara M, Kuramochi M, Takigawa M, Yanagisawa M, Sakurai T, Shioda S, Yada T.
Orexins (hypocretins) directly interact with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus.
Eur J Neurosci. 2004 Mar;19(6):1524-34.
Yanagita M, Oka M, Watabe T, Iguchi H, Niida A, Takahashi S, Akiyama T, Miyazono K, Yanagisawa M, Sakurai T.
USAG-1: a bone morphogenetic protein antagonist abundantly expressed in the kidney.
Biochem Biophys Res Commun. 2004 Apr 2;316(2):490-500.
PMID: 15020244
2005 2004 2003 2002 2001 2000 1999 1998


2003

Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M, Sakurai T.
Hypothalamic orexin neurons regulate arousal according to energy balance in mice.
Neuron. 2003 Jun 5;38(5):701-13.
PMID: 12797956
Zhu Y, Miwa Y, Yamanaka A, Yada T, Shibahara M, Abe Y, Sakurai T, Goto K.
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins.
J Pharmacol Sci. 2003 Jul;92(3):259-66.
PMID: 12890892 [PubMed - in process]
Tanaka H, Yoshida T, Miyamoto N, Motoike T, Kurosu H, Shibata K, Yamanaka A, Williams SC, Richardson JA, Tsujino N, Garry MG, Lerner MR, King DS, O'Dowd BF, Sakurai T, Yanagisawa M.
Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.
Proc Natl Acad Sci U S A. 2003 May 13;100(10):6251-6. Epub 2003 Apr 28.
PMID: 12719537 [PubMed - indexed for MEDLINE]
Yamanaka A, Muraki Y, Tsujino N, Goto K, Sakurai T.
Regulation of orexin neurons by the monoaminergic and cholinergic systems.
Biochem Biophys Res Commun. 2003 Mar 28;303(1):120-9.
PMID: 12646175 [PubMed - indexed for MEDLINE]
Toshinai K, Date Y, Murakami N, Shimada M, Mondal MS, Shimbara T, Guan JL, Wang QP, Funahashi H, Sakurai T, Shioda S, Matsukura S, Kangawa K, Nakazato M.
Ghrelin-induced food intake is mediated via the orexin pathway.
Endocrinology. 2003 Apr;144(4):1506-12.
PMID: 12639935 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998

2002
Li Y, Gao XB, Sakurai T, van den Pol AN.
Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system.
Neuron. 2002 Dec 19;36(6):1169-81.
PMID: 12495630 [PubMed - indexed for MEDLINE]
Sakurai T.
Roles of orexins in the regulation of feeding and arousal.
Sleep Med. 2002 Dec;3 Suppl 2:S3-9.
PMID: 14592371 [PubMed]
Zhu Y, Yamanaka A, Kunii K, Tsujino N, Goto K, Sakurai T.
Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways.
Physiol Behav. 2002 Nov;77(2-3):251-7.
PMID: 12419401 [PubMed - indexed for MEDLINE]
Sakurai T.
Roles of orexins in the regulation of feeding and arousal.
Sleep Med. 2002 Dec;3 Suppl 2:S3-9.
PMID: 14592371 [PubMed]
Matsuzaki I, Sakurai T, Kunii K, Nakamura T, Yanagisawa M, Goto K.
Involvement of the serotonergic system in orexin-induced behavioral alterations in rats.
Regul Pept. 2002 Mar 15;104(1-3):119-23.
PMID: 11830286 [PubMed - indexed for MEDLINE]
Nanmoku T, Isobe K, Sakurai T, Yamanaka A, Takekoshi K, Kawakami Y, Goto K, Nakai T.
Effects of orexin on cultured porcine adrenal medullary and cortex cells.
Regul Pept. 2002 Mar 15;104(1-3):125-30.
PMID: 11830287 [PubMed - indexed for MEDLINE]
Moriguchi T, Sakurai T, Takahashi S, Goto K, Yamamoto M.
The human prepro-orexin gene regulatory region that activates gene expression in the lateral region and represses it in the medial regions of the hypothalamus.
J Biol Chem. 2002 May 10;277(19):16985-92. Epub 2002 Feb 19.
PMID: 11854267 [PubMed - indexed for MEDLINE]
Yamanaka A, Tsujino N, Funahashi H, Honda K, Guan JL, Wang QP, Tominaga M, Goto K, Shioda S, Sakurai T.
Orexins activate histaminergic neurons via the orexin 2 receptor.
Biochem Biophys Res Commun. 2002 Feb 1;290(4):1237-45.
PMID: 11811995 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998

2001

Iqbal J, Pompolo S, Sakurai T, Clarke IJ.
Evidence that orexin-containing neurones provide direct input to gonadotropin-releasing hormone neurones in the ovine hypothalamus.
J Neuroendocrinol. 2001 Dec;13(12):1033-41.
Iqbal J, Pompolo S, Murakami T, Grouzmann E, Sakurai T, Meister B, Clarke IJ.
Immunohistochemical characterization of localization of long-form leptin receptor (OB-Rb) in neurochemically defined cells in the ovine hypothalamus.
Brain Res. 2001 Nov 30;920(1-2):55-64.
PMID: 11716811 [PubMed - indexed for MEDLINE]
Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB, Scammell TE.
Orexin (hypocretin) neurons contain dynorphin.
J Neurosci. 2001 Oct 1;21(19):RC168.
PMID: 11567079 [PubMed - indexed for MEDLINE]
Muroya S, Uramura K, Sakurai T, Takigawa M, Yada T.
Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus.
Neurosci Lett. 2001 Aug 31;309(3):165-8.
PMID: 11514067 [PubMed - indexed for MEDLINE]
Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M, Sakurai T.
Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity.
Neuron. 2001 May;30(2):345-54.
PMID: 11394998 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998

2000

Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.
Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients.
Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31.
PMID: 10964697 [PubMed - indexed for MEDLINE]
Nakamura T, Uramura K, Nambu T, Yada T, Goto K, Yanagisawa M, Sakurai T.
Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system.
Brain Res. 2000 Aug 4;873(1):181-7.
PMID: 10915829 [PubMed - indexed for MEDLINE]
Yamanaka A, Kunii K, Nambu T, Tsujino N, Sakai A, Matsuzaki I, Miwa Y, Goto K, Sakurai T.
Orexin-induced food intake involves neuropeptide Y pathway.
Brain Res. 2000 Mar 24;859(2):404-9.
PMID: 10719096 [PubMed - indexed for MEDLINE]
Abe Y, Sakurai T, Yamada T, Nakamura T, Yanagisawa M, Goto K.
Functional analysis of five endothelin-B receptor mutations found in human Hirschsprung disease patients.
Biochem Biophys Res Commun. 2000 Aug 28;275(2):524-31.
PMID: 10964697 [PubMed - indexed for MEDLINE]
Abe Y, Nakayama K, Yamanaka A, Sakurai T, Goto K.
Subtype-specific trafficking of endothelin receptors.
J Biol Chem. 2000 Mar 24;275(12):8664-71.
PMID: 10722707 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998

1999

Yamanaka A, Sakurai T, Katsumoto T, Yanagisawa M, Goto K.
Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight.
Brain Res. 1999 Dec 4;849(1-2):248-52.
PMID: 10592311 [PubMed - indexed for MEDLINE]
Sakurai T.
Orexins and orexin receptors: implication in feeding behavior.
Regul Pept. 1999 Nov 30;85(1):25-30. Review.
PMID: 10588447 [PubMed - indexed for MEDLINE]
Shibahara M, Sakurai T, Nambu T, Takenouchi T, Iwaasa H, Egashira SI, Ihara M, Goto K.
Structure, tissue distribution, and pharmacological characterization of Xenopus orexins.
Peptides. 1999;20(10):1169-76.
PMID: 10573288 [PubMed - indexed for MEDLINE]
Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K, Sakurai T.
Orexins/hypocretins regulate drinking behaviour.
Brain Res. 1999 Sep 18;842(1):256-61.
PMID: 10526122 [PubMed - indexed for MEDLINE]
Sakurai T, Moriguchi T, Furuya K, Kajiwara N, Nakamura T, Yanagisawa M, Goto K.
Structure and function of human prepro-orexin gene.
J Biol Chem. 1999 Jun 18;274(25):17771-6.
PMID: 10364220 [PubMed - indexed for MEDLINE]
Nambu T, Sakurai T, Mizukami K, Hosoya Y, Yanagisawa M, Goto K.
Distribution of orexin neurons in the adult rat brain.
Brain Res. 1999 May 8;827(1-2):243-60.
PMID: 10320718 [PubMed - indexed for MEDLINE]
Moriguchi T, Sakurai T, Nambu T, Yanagisawa M, Goto K.
Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia.
Neurosci Lett. 1999 Apr 2;264(1-3):101-4.
PMID: 10320024 [PubMed - indexed for MEDLINE]
Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M.
Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):748-53.
PMID: 9892705 [PubMed - indexed for MEDLINE]
Gonda K, Okamoto H, Takuwa N, Yatomi Y, Okazaki H, Sakurai T, Kimura S, Sillard R, Harii K, Takuwa Y.
The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.
Biochem J. 1999 Jan 1;337 ( Pt 1):67-75.
PMID: 9854026 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998

1998
Elias CF, Saper CB, Maratos-Flier E, Tritos NA, Lee C, Kelly J, Tatro JB, Hoffman GE, Ollmann MM, Barsh GS, Sakurai T, Yanagisawa M, Elmquist JK.
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area.
J Comp Neurol. 1998 Dec 28;402(4):442-59.
PMID: 9862320 [PubMed - indexed for MEDLINE]
Lecoin L, Sakurai T, Ngo MT, Abe Y, Yanagisawa M, Le Douarin NM.
Cloning and characterization of a novel endothelin receptor subtype in the avian class.
Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3024-9.
PMID: 9501209 [PubMed - indexed for MEDLINE]
Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M.
Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.
Cell. 1998 Feb 20;92(4):573-85.
PMID: 9491897 [PubMed - indexed for MEDLINE]
2005 2004 2003 2002 2001 2000 1999 1998
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