̘_Xg2021
  1. Nishimura S and Nakagama H. Takashi Sugimura: In Memoriam (1926–2020)–A Personal Perspective.Cancer Res January 1 2021 81 (1) 3-4; DOI:10.1158/0008-5472.CAN-20-3998.

  2. Yumoto A, Kokubo T, Izumi R, Shimomura M, Funatsu O, Tada MN, Ota-Murakami N, Iino K, Shirakawa M, Mizuno H, Kudo TTakahashi S, Suzuki T, Uruno A, Yamamoto M, Shiba D. Novel method for evaluating the health condition of mice in space through a video downlink. Exp Anim. 2021 May 13;70(2):236-244. doi: 10.1538/expanim.20-0102. Epub 2021 Jan 22.

  3. Shimomura M, Yumoto A, Ohta-Murakami N, Kudo T, Shirakawa M, Takahashi S, Morita H, Shiba D. Study of mouse behavior in different gravity environments. Sci Rep. 2021 Jan 29;11(1):2665. doi: 10.1038/s41598-021-82013-w.

  4. Sasaki T, Nagata R, Takahashi S, Takei Y. Effects of RORγt overexpression on murine central nervous system. Neuropsychopharmacol Rep. 2021 Mar;41(1):102-110. doi: 10.1002/npr2.12162.

  5. Ishii S, Suzuki T, Wakahashi K, Asada N, Kawano Y, Kawano H, Sada A, Minagawa K, Nakamura Y, Mizuno S, Takahashi S, Matsui T, Katayama Y. FGF23 from erythroblasts promotes hematopoietic progenitor mobilization. Blood. 2021 Mar 18;137(11):1457-1467. doi: 10.1182/blood.2020007172.

  6. Iwasaki K, Fujiyama T, Nakata S, Park M, Mioshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M, Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M. Induction of mutant Sik3Sleepy allele in neurons in late infancy increases sleep need. J Neurosci. 2021 Mar 24;41(12):2733-2746. doi: 10.1523/JNEUROSCI.1004-20.2020. Epub 2021 Feb 8.

  7. Jeon H, Asano K, Wakimoto A, Kulathunga K, Tran MTN, Nakamura M, Yokomizo T, Hamada M ,Takahashi S. Generation of reconstituted hemato-lymphoid murine embryos by placental transplantation into embryos lacking HSCs. Sci Rep. 2021 Feb 23; 11:4374. doi:10.1038/s41598-021-83652-9.

  8. Suzuki T, Ishii S, Shinohara M, Kawano Y, Wakahashi K, Kawano H, Sada A, Minagawa K, Hamada M, Takahashi S, Furuyashiki T, Tan NS, Matsui T, Katayama Y. Mobilization efficiency is critically regulated by fat via marrow PPARδ. Hematologia. 2021 Jun 1;106(6):1671-1683. doi: 10.3324/haematol.2020.265751.

  9. Takahashi S. Functional analysis of large MAF transcription factors and elucidation of their relationship with human diseases. Exp Anim. 2021 Aug 6;70(3):264-271. doi: 10.1538/expanim.21-0027. Epub 2021 Mar 2.

  10. Okada R, Suzuki R, Hayashi T, Fujita S, Tsubouchi H, Kato C, Sadaki S, Kanai M, Fuseya S, Inoue Y, Jeon H, Hamada M, Kuno A, Muratani M, Ishii A, Tamaoka A, Tanihata J, Ito N, Takeda S, Shiba D, Shirakawa M, Kudo T, Takahashi S. Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1G onboard environment. Sci Rep. 2021 Apr 28;11(1):9168. doi: 10.1038/s41598-021-88392-4.

  11. Dinh TTH, Iseki H, Mizuno S, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM, Sugiyama F. Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. eLife. 2021 May 5;10:e50346. doi: 10.7554/eLife.50346.

  12. Miura I, Komine S, Okada K, Wada S, Warabi E, Uchida F, Oh S, Suzuki H, Mizokami Y, Shoda J. Prevention of non-alcoholic steatohepatitis by long-term exercise via the induction of phenotypic changes in Kupffer cells of hyperphagic obese mice. Physiol Rep. 2021 May;9(9):e14859. doi: 10.14814/phy2.14859.

  13. Osawa Y, Murata K, Usui M, Kuba Y, Le HT, Mikami N, Nakagawa T, Daitoku Y, Kato K, Shawki HH, Ikeda Y, Kuno A, Morimoto K, Tanimoto Y, Dinh TTH, Yagami KI, Ema M, Yoshida S, Takahashi S, Mizuno S, Sugiyama F. EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. eLife. 2021 May 11;10:e59759. doi: 10.7554/eLife.59759.

  14. Hashimoto D, Colet JGR, Murashima A, Fujimoto K, Ueda Y, Suzuki K, Hyuga T, Hemmi H, Kaisho T, Takahashi S, Takahama Y, Yamada G. Radiation inducible MafB gene is required for thymic regeneration. Sci Rep. 2021 May 17;11(1):10439. doi: 10.1038/s41598-021-89836-7.

  15. Furukawa S, Chatani M, Higashitani A, Higashibata A, Kawano F, Nikawa T, Numaga-Tomita T, Ogura T, Sato F, Sehara-Fujisawa A, Shinohara M, Shimazu T, Takahashi S, Watanabe-Takano H. Findings from recent studies by the Japan Aerospace Exploration Agency examining musculoskeletal atrophy in space and on Earth. NPJ Microgravity. 2021 May 26;7(1):18. doi: 10.1038/s41526-021-00145-9.

  16. Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H. Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling. FASEB J. 2021 Jun;35(6):e21663. doi: 10.1096/fj.202002784RR.

  17. Koldaeva A, Zhang C, Huang YP, Reinert JK, Mizuno S, Sugiyama F, Takahashi S, Soliman T, Matsunami H, Fukunaga I. Generation and characterisation of a cell-type specific, inducible Cre-driver line to study olfactory processing. J Neurosci. 2021 Jul 28;41(30):6449-6467. doi: 10.1523/JNEUROSCI.3076-20.2021. Epub 2021 Jun 7.

  18. Kimura K, Ooms A, Graf-Riesen K, Kuppusamy M, Unger A, Schuld J, Daerr J, Lother A, Geisen C, Hein L, Takahashi S, Li G, Röll W, Bloch W, van der Ven PFM, Linke WA, Wu SM, Huesgen PF, Höhfeld J, Fürst DO, Fleischmann BK, Hesse M. Overexpression of human BAG3 (P209L) in mice causes restrictive cardiomyopathy. Nat Commun2021 Jun 11;12(1):3575. doi: 10.1038/s41467-021-23858-7.

  19. Hayashi T, Kudo T, Fujita R, Fujita SI, Tsubouchi H, Fuseya S, Suzuki R, Hamada M, Okada R, Muratani M, Shiba D, Suzuki T, Warabi E, Yamamoto M, Takahashi S. Nuclear factor E2-related factor 2 (NRF2) deficiency accelerates fast fibre type transition in soleus muscle during space flight. Commun Biol. 2021 Jun 24;4(1):787. doi: 10.1038/s42003-021-02334-4.

  20. Yoshihara M, Nishino T, Yadav MK, Kuno A, Nagata T, Ando H, Takahashi S. Mathematical analysis of the effect of portal vein cells on biliary epithelial cell differentiation through the Delta-Notch signaling pathway. BMC Res Notes. Jun 29;14(1):243. doi: 10.1186/s13104-021-05656-y.

  21. Yoshida K, Fujita S-i, Isotani A, Kudo T, Takahashi S, Ikawa M, Shiba D, Shirakawa M, Muratani M, Ishii S. Intergenerational effect of short-term spaceflight in mice. iScience. 2021 Jun 25;24(7):102773. doi: 10.1016/j.isci.2021.102773.

  22. Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Mizuno S, Takahashi S, Fujimoto M, Okiyama N. Differential involvement of programmed cell death ligands in skin immune responses. J Invest Dermatol. 2021 Jul 23:S0022-202X(21)01458-5. doi: 10.1016/j.jid.2021.06.026

  23. Suzuki S. R, Kuno A, Ozaki H. Cell-to-cell interaction analysis of prognostic ligand-receptor pairs in human pancreatic ductal adenocarcinoma. BB reports. 2021 Aug 31; 28:101126.. doi: 10.1016/j.bbrep.2021.101126.

  24. Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A. A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv. 2021 Sep 24;7(39):eabi7514. doi: 10.1126/sciadv.abi7514. Epub 2021 Sep 24.

  25. Mizuno M, Khaledian B, Maeda M, Hayashi T, Mizuno S, Munetsuna E, Watanabe T, Kono S, Okada S, Suzuki M, Takao S, Minami H, Asai N, Sugiyama F, Takahashi S, Shimono Y. Adipsin-dependent secretion of hepatocyte growth factor regulates the adipocyte-cancer stem cell interaction. Cancers (Basel). 2021 Aug 23;13(16):4238. doi: 10.3390/cancers13164238.

  26. Nishida M, Yamashita N, Ogawa T, Koseki K, Warabi E, Ohue T, Komatsu M, Matsushita H, Kakimi K, Kawakami E, Shiroguchi K, Udono H. Mitochondrial reactive oxygen species trigger metformin-dependent antitumor immunity via activation of Nrf2/mTORC1/p62 axis in tumor-infiltrating CD8T lymphocytes. J Immunother Cancer. 2021 Sep;9(9):e002954. doi: 10.1136/jitc-2021-002954.

  27. Nakagawa T, Jörg DJ, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons BD, Yoshida S, Nagasawa T. A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Rep. 2021 Oct 19;37(3):109875. doi: 10.1016/j.celrep.2021.109875.

  28. Ishii T, Warabi E, Mann GE. Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary cilia. Redox Biol. 2021 Oct;46:102103. doi: 10.1016/j.redox.2021.102103.

  29. Kulathunga K, Wakimoto A, Hiraishi Y, Yadav MK, Gentleman K, Warabi E, Sakasai T, Miwa Y, Mizuno S, Takahashi S, Hamada M. Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility. Sci Rep. 2021 Nov 8;11(1):21827. doi: 10.1038/s41598-021-00501-5.

  30. Suzuki N, Iwamura Y, Nakai T, Kato K, Otsuki A, Uruno A, Saigusa D, Taguchi K, Suzuki M, Shimizu R, Yumoto A, Okada R, Shirakawa M, Shiba D, Takahashi S, Suzuki T, Yamamoto M. Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel. Kidney Int. 2021 Nov 9:S0085-2538(21)01030-9. doi: 10.1016/j.kint.2021.09.031.

  31. Borisova E, Nishimura K, An Y, Takami M, Li J, Song D, Matsuo-Takasaki M, Luijkx D, Aizawa S, Kuno A, Sugihara E, Sato T, Yumoto F, Terada T, Hisatake K, Hayashi Y. Structurally-discovered KLF4 variantsaccelerate and stabilizereprogramming to pluripotency. i Science, 2021,Dec 14 :103525.doi:10.1016/j.isci.2021.103525.

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