Publication 2022
  1. Aizawa S, Nishimura K, Mondejar GS, Kumar A, Bui PL, Tran YTH, Kuno A, Muratani M, Kobayashi S, Nabekura T, Shibuya A, Sugihara E, Sato TA, Fukuda A, Hayashi Y, Hisatake K. Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming. Stem Cell Reports. 2022 Jan 11;17(1):53-67. doi: 10.1016/j.stemcr.2021.11.008. Epub 2021 Dec 16.

  2. Kuno A, Ikeda Y, Ayabe S, Kato K, Sakamoto K, Suzuki SR, Morimoto K, Wakimoto A, Mikami N, Ishida M, Iki N, Hamada Y, Takemura M, Daitoku Y, Tanimoto Y, Dinh TTH, Murata K, Hamada M, Muratani M, Yoshiki A, Sugiyama F, Takahashi S, Mizuno S. DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes. PLoS Biol. 2022 Jan 18; 20(1):e3001507. doi: 10.1371/journal.pbio.3001507. eCollection 2022 Jan. PMID: 35041655

  3. Suzuki R, Nakamura Y, Koiwai R, Fuseya S,Murakami Y,Hagiwara K, Sato T, Takahashi S and Kudo T, Global Loss of Core 1-Derived O-Glycans in Mice Leads to High Mortality Due to Acute Kidney Failure and Gastric Ulcers. Int. J. Mol. Sci. 2022 Jan 24; 23 (3), 1273. https://doi.org/10.3390/ijms23031273.

  4. Horie T, Fukasawa K, Yamada T, Mizuno S, Iezaki T, Tokumura K, Iwahashi S, Sakai S, Suzuki A, Kubo T, Osumi R, Tomizawa A, Ochi H, Sato S, Kaneda K, Takahashi S, Hinoi E. Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood. Stem Cells. 2022 Feb 22: sxac011. doi: 10.1093/stmcls/sxac011.

  5. Xu S, Hu G, Wu D, Kan X, Oishi H, Takahashi S, Fu S, Liu J, Zhang C. MafK accelerates Salmonella mucosal infection through caspase-3 activation. Aging (Albany NY). 2022 Mar 8;14(5):2287-2303. doi: 10.18632/aging.203938.

  6. Tsukimoto S, Hakata Y, Tsuji-Kawahara S, Enya T, Tsukamoto T, Mizuno S, Takahashi S, Nakao S, Miyazawa M. Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells. Viruses. 2022 Apr 17; 14(4):832. doi: 10.3390/v14040832.

  7. Anh LPH, Nishimura K, Kuno A, Linh NT, Kato T, Ohtaka M, Nakanishi M, Sugihara E, Sato TA, Hayashi Y, Fukuda A, Hisatake K. Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming. Stem Cells. 2022 Apr 29; 40(4):397-410. doi: 10.1093/stmcls/sxac012.

  8. Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6):3201. doi: 10.3390/ijms23063201.
  9. Le PHA, Nihimura K, Kuno A, Nguyen TL, Kato T, Ohtaka M, Nakanishi M, Sugihara E, Sato TA, Hayashi Y, Fukuda A, Hisatake K. Downregulation of Odd-Skipped Related 2, a Novel Regulator of Epithelial-Mesenchymal Transition, Enables Efficient Somatic Cell Reprogramming. Stem Cells, 2022 Apr 29;40(4):397-410. doi: 10.1093/stmcls/sxac012.

  10. Nishino T, Yoshihara M, Nakayama T, Tsuchiya T, Tahara S, Ozaki H, Takahashi S. Identifying potential regulators of JAGGED1 expression in portal mesenchymal cells. BMC Res Notes. 2022 May 13;15(1):172. doi: 10.1186/s13104-022-06058-4.

  11. Ono M, Komatsu M, Ji B, Takado Y, Shimojo M, Minamihisamatsu T, Warabi E, Yanagawa T, Matsumoto G, Aoki I, Kanaan NM, Suhara T, Sahara N, Higuchi M. Central role for p62/SQSTM1 in the elimination of toxic tau species in a mouse model of tauopathy. Aging Cell. 2022 Jul;21(7):e13615. doi: 10.1111/acel.13615. Epub 2022 Jun 5. PMID: 35662390 Free PMC article.

  12. Takiyama M, Matsumoto T, Kaifuchi N, Mizuhara Y, Warabi E, Ohbuchi K, Mizoguchi K. In vitro assessment of the inhibitory effect of goreisan extract and its ingredients on the P-glycoprotein drug transporter and cytochrome P-450 metabolic enzymes. Xenobiotica. 2022 May;52(5):511-519. doi: 10.1080/00498254.2022.2078750. Epub 2022 Jul 25. PMID: 35855663

  13. Yoshikawa M, Ishikawa C, Li H, Kudo T, Shiba D, Shirakawa M, Muratani M, Takahashi S, Aizawa S, Shiga T. Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord. Mol Cell Neurosci. 2022 Jun 2;121:103745. doi: 10.1016/j.mcn.2022.103745

  14. Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, Kubota R, Doura T, Miura E, Nonaka H, Mizuno S, Takahashi S, Yuzaki M, Hamachi I, Kiyonaka S. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Nat Commun. 2022 Jun 16;13(1):3167. doi: 10.1038/s41467-022-30828-0. PMID: 3571078.

  15. Tanaka R, Ichimura Y, Kubota N, Konishi R, Nakamura Y, Mizuno S, Takahashi S, Fujimoto M, Nomura T, Okiyama N. The role of programmed cell death ligand-1 on Langerhans cells in the regulation of psoriasis. J Invest Dermatol. 2022 Jul 5:S0022-202X(22)01645doi: 10.1016/j.jid.2022.06.006.

  16. Teruyama F, Kuno A, Murata Y, Nakagawa T, Shiba-Ishii A, Yuguchi S, Noguchi M. Mutational landscape of primary breast angiosarcoma with repeated resection and recurrence over a 15-year period: A case report. Pathol Int. 2022 Jul 8. doi: 10.1111/pin.13257. Online ahead of print. PMID: 35801418

  17. Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Min-Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS & Kim SJ. Mast4 determines the cell fate of MSCs for bone and cartilage development. Nat Commun, 2022 Jul 8; 13(1):3960, doi:10.1038/s41467-022-31697-3.PMID:35803931.

  18. Tanimoto Y, Mikami N, Ishida M, Iki N, Kato K, Sugiyama F, Takahashi S, Mizuno S. Zygote Microinjection for Creating Gene Cassette Knock-in and Flox Alleles in Mice. J Vis Exp. 2022 Jun 24;(184). doi: 10.3791/64161.

  19. Yanagawa T, Hirayama A, Osada K, Kuno A, Takahashi S. Sufficient liver erythropoietin synthesis is induced in hemodialysis patients not requiring erythropoiesis-stimulating agents. Clin Nephrol. 2022 Jul 12. doi: 10.5414/CN11074

  20. Nishida-Tamehiro K, Kimura A, Tsubata T, Takahashi S, Suzuki H. Antioxidative enzyme NAD(P)H quinone oxidoreductase 1 (NQO1) modulates the differentiation of Th17 cells by regulating ROS levels. PLoS One. 2022 Jul 29;17(7):e0272090. doi: 10.1371/journal.pone.0272090.

  21. Fujisawa M, Nguyen TB, Abe Y, Suehara Y, Fukumoto K, Suma S, Makishima K, Kaneko C, Nguyen YTM, Usuki K, Narita K, Matsue K, Nakamura N, Ishikawa S, Miura F, Ito T, Suzuki A, Suzuki Y, Mizuno S, Takahashi S, Chiba S, Sakata-Yanagimoto M. Clonal germinal center B cells function as a niche for T-cell lymphoma. Blood. 2022 Aug 3:blood.2022015451. doi: 10.1182/blood.2022015451.

  22. Yoshihara M, Nishino T, Sambe N, Nayakama T, Radtke F, Mizuno S, Takahashi S. Generation of a Gal4-dependent gene recombination and illuminating mouse. Exp Anim.2022 Aug 5;71(3):385-390. doi: 10.1538/expanim.21-0202. Epub 2022 Apr 21.

  23. Deng Z, Kuno A, Ojima M, Takahashi S. MafB Maintains β-Cell Identity under MafA-Deficient Conditions. Mol. Cell. Biol. 2022 Aug 18;42(8):e0054121. doi: 10.1128/mcb.00541-21. Epub 2022 Jul 11.

  24. Inoue Y, Liao CW, Tsunakawa Y, Tsai IL, Takahashi S, Hamada M. Macrophage-Specific, Mafb-Deficient Mice Showed Delayed Skin Wound Healing. Int. J. Mol. Sci. 2022, Aug 19. 23(16), 9346; doi:10.3390/ijms23169346.

  25. Samir O, Kobayashi N, Nishino T, Siyam M, Yadav MK, Inoue Y, Takahashi S and Hamada M. Transcription Factor MAFB as a Prognostic Biomarker for the Lung Adenocarcinoma.Int. J. Mol. Sci. 2022 Sep 1;23(17):9945. doi: 10.3390/ijms23179945.

  26. Mitsui S, Otomo A, Sato K, Ishiyama M, Shimakura K, Okada-Yamaguchi C, Warabi E, Yanagawa T, Aoki M, Shang HF, Hadano S. SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron. Neurochem Int. 2022 Sep;158:105364. doi: 10.1016/j.neuint.2022.105364. Epub 2022 May 28.

  27. Kitamura Y, Suzuki A, Uranishi K, Nishimoto M, Mizuno S, Takahashi S, Okuda A. Alternative splicing for germ cell-specific Mga transcript can be eliminated without compromising mouse viability or fertility. Dev Growth Differ. 2022 Sep;64(7):409-416. doi: 10.1111/dgd.12806. Epub 2022 Sep 14.PMID: 36053973.

  28. Watahiki T, Okada K, Miura I, To K, Tanaka S, Warabi E, Kanno N, Yamagata K, Gotoh N, Suzuki H, Ariizumi S, Tsuchiya K, Nagasaki Y, Shoda J. Antioxidative Self-Assembling Nanoparticles Attenuate the Development of Steatohepatitis and Inhibit Hepatocarcinogenesis in Mice. Antioxidants (Basel)..2022 Sep 28;11(10):1939. doi: 10.3390/antiox11101939. PMID: 36290662 Free PMC article.

  29. Ishii T, Warabi E, Mann GE. Mechanisms underlying Nrf2 nuclear translocation by non-lethal levels of hydrogen peroxide: p38 MAPK-dependent neutral sphingomyelinase2 membrane trafficking and ceramide/PKCζ/CK2 signaling. Free Radic Biol Med. 2022 Oct;191:191-202. doi: 10.1016/j.freeradbiomed.2022.08.036. Epub 2022 Sep 3. PMID: 36064071 Review.

  30. Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I. Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli. PLoS One. 2022 Oct 6;17(10):e0275751. doi: 10.1371/journal.pone.0275751.

  31. Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y. Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol. 2022 Oct 17;57:102514. doi: 10.1016/j.redox.2022.102514. Online ahead of print. PMID: 36279630 Free PMC article.

  32. Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y. Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol. 2022 Oct 17;57:102514. doi: 10.1016/j.redox.2022.102514. Online ahead of print. PMID: 36279630 Free PMC article.

  33. Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S, Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani KI, Ema M. Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice. Life (Basel). 2022 Oct 28;12(11):1730. doi: 10.3390/life12111730.

  34. Miura I, Okada K, Ishii A, Warabi E, Watahiki T, To K, Shimano H, Ariizumi S, Shoda. p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet. J. Front Physiol. 2022 Nov 1;13:993995. doi: 10.3389/fphys.2022.993995. eCollection 2022. PMID: 36439272 Free PMC article.

  35. Kmar A, Nishimura K, Kishimoto T, Hamzah M, Kuno A, Fukuda A, Hisatake K. Locus-Specific Isolation of the Nanog Chromatin Identifies Regulators Relevant to Pluripotency of Mouse Embryonic Stem Cells and Reprogramming of Somatic Cells. Int. J. Mol. Sci. 2022, 23(23), 15242,doi:10.3390/ijms232315242 (registering DOI)

  36. Alcantara MC, Suzuki K, Acebedo AR, Kajioka D, Hirohata S, Kaisho T, Hatano Y, Yamagata K, Takahashi S, Yamada G. Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice. iScience. 2022 Nov 16;25(12):105609. doi: 10.1016/j.isci.2022.105609.

  37. Ma NS, Mumm S, Takahashi S, Levine MA. Multicentric Carpotarsal Osteolysis: a Contemporary Perspective on the Unique Skeletal Phenotype. Curr Osteoporos Rep. 2022 Dec 7. doi: 10.1007/s11914-022-00762-7.

  38. Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M, Funato H. Kinase signalling in excitatory neurons regulates sleep quantity and depth. Nature. 2022 Dec 7. doi: 10.1038/s41586-022-05450-1.

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