Publication 2023
  1. Fujino M, Morito N, Hayashi T, Ojima M, Ishibashi S, Kuno A, Koshiba S, Yamagata K, Takahashi S. Transcription factor c-Maf deletion improves streptozotocin-induced diabetic nephropathy by directly regulating Sglt2 and Glut2. JCI Insight.2023 Feb 14:e163306. doi: 10.1172/jci.insight.163306. Online ahead of print.

  2.  Asano F, Kim SJ, Fujiyama T, Miyoshi C, Hotta-Hirashima N, Asama N, Iwasaki K, Kakizaki M, Mizuno S, Mieda M, Sugiyama F, Takahashi S, Shi S, Hirano A, Funato H, Yanagisawa M. SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice. Proc Natl Acad Sci U S A. 2023 Mar 14;120(11):e2218209120. doi: 10.1073/pnas.2218209120.

  3. Larrayoz M, Garcia-Barchino MJ, Celay J, Etxebeste A, Jimenez M, Perez C, Ordoñez R, Cobaleda C, Botta C, Fresquet V, Roa S, Goicoechea I, Maia C, Lasaga M, Chesi M, Bergsagel PL, Larrayoz MJ, Calasanz MJ, Campos-Sanchez E, Martinez-Cano J, Panizo C, Rodriguez-Otero P, Vicent S, Roncador G, Gonzalez P, Takahashi S, Katz SG, Walensky LD, Ruppert SM, Lasater EA, Amann M, Lozano T, Llopiz D, Sarobe P, Lasarte JJ, Planell N, Gomez-Cabrero D, Kudryashova O, Kurilovich A, Revuelta MV, Cerchietti L, Agirre X, San Miguel J, Paiva B, Prosper F, Martinez-Climent JA. Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma. Nat Med. 2023 Mar 16. doi: 10.1038/s41591-022-02178-3.

  4. Kawano S, Araki K, Bai J, Furukawa I, Tateishi K, Yoshinobu K, Usuki S, Nimmo RA, Kaname T, Yoshihara M, Takahashi S, Sashida G, Araki M. A gain-of-function mutation in micro-RNA-142 is sufficient to cause the development of T-cell leukemia in mice. Cancer Sci. 2023 Mar 21. doi: 10.1111/cas.15794.

  5. Sadaki S, Fujita R, Hayashi T, Nakamura A, Okamura Y, Fuseya S, Hamada M, Warabi E, Kuno A, Ishii A, Muratani M, Okada R, Shiba D, Kudo T, Takeda S, Takahashi S. Large Maf transcription factor family is a major regulator of fast type IIb myofiber determination. Cell Rep. 2023 Mar 22;42(4):112289. doi: 10.1016/j.celrep.2023.112289.

  6. Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda R, Hirotani K, Sakata D, Mizuno S, Takahashi S, Bamba T, Uruno T, Fukui Y. Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury. Front Immunol. 2023 Mar 17;14:1131146. doi: 10.3389/fimmu.2023.1131146.　

  7. Sanada Y, Ikuta Y, Ding C, Yimiti D, Kato Y, Nakasa T, Mizuno S, Takahashi S, Huang W, Lotz MK, Adachi N, Miyaki S. miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis. Mech Ageing Dev. 2023 Mar 30:111806. doi: 10.1016/j.mad.2023.111806.

  8. Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai SI, Satoh A. Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice. Life Sci Alliance. 2023 Apr 12;6(6):e202301992. doi: 10.26508/lsa.202301992.　

  9. Sugiura R, Nakayama T, Nishino T, Sambe N, Radtke F, Yoshihara M, Takahashi S. Notch1 signaling is limited in healthy mature kidneys in vivo. BMC Res Notes. 2023 Apr 17;16(1):54. doi: 10.1186/s13104-023-06326-x.　

  10. Hayashi T, Fujita R, Okada R, Hamada M, Suzuki R, Fuseya S, Leckey J, Kanai M, Inoue Y, Sadaki S, Nakamura A, Okamura Y, Abe C, Morita H, Aiba T, Senkoji T, Shimomura M, Okada M, Kamimura D, Yumoto A, Muratani M, Kudo T, Shiba D, Takahashi S. Lunar gravity prevents skeletal muscle atrophy but not myofiber type shift in mice. Commun Biol. 2023 Apr 21;6(1):424. doi: 10.1038/s42003-023-04769-3. PMID: 37085700

  11. Fujino M, Ojima M, Ishibashi S, Mizuno S, Takahashi S. Generation and mutational analysis of a transgenic murine model of the human MAF mutation. Am. J. med. Genet. 2023 Apr.23. 1-11.doi：10.1002/ajmg.a.63220

  12. Prokofeva K, Saito YC, Niwa Y, Mizuno S, Takahashi S, Hirano A, Sakurai T. Structure and Function of Neuronal Circuits linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area. J Neurosci. 2023 Apr 27:JN-RM-1913-22. doi: 10.1523/JNEUROSCI.1913-22.2023.

  13. Gogoleva N, Shahari ZJ, Noda A, Ching-Wei L, Wakimoto A, Inoue Y, Jeon H, Takahashi S, Hamada M. Intraplacental injection of AAV9-CMV-iCre results in the widespread transduction of multiple organs in double-reporter mouse embryos.Exp Anim.2023 May 12. doi: 10.1538/expanim.23-0044. in press.

  14. Fujita R, Mizuno S, Sadahiro T, Hayashi T, Sugasawa T, Sugiyama F, Ono Y, Takahashi S, Ieda M. Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity. iScience. 2023 Apr 8;26(5):106592. doi: 10.1016/j.isci.2023.106592.

  15. Shima Y, Sasagawa S, Ota N, Oyama R, Tanaka M, Kubota-Sakashita M, Kawakami H, Kobayashi M, Takubo N, Ozeki AN, Sun X, Kim YJ, Kamatani Y, Matsuda K, Maejima K, Fujita M, Noda K, Kamiyama H, Tanikawa R, Nagane M, Shibahara J, Tanaka T, Rikitake Y, Mataga N, Takahashi S, Kosaki K, Okano H, Furihata T, Nakaki R, Akimitsu N, Wada Y, Ohtsuka T, Kurihara H, Kamiguchi H, Okabe S, Nakafuku M, Kato T, Nakagawa H, Saito N, Nakatomi H. Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms. Sci Transl Med. 2023 Jun 14;15(700):eabq7721. doi: 10.1126/scitranslmed.abq7721.

  16. Sambe N, Yoshihara M, Nishino T, Sugiura R, Nakayama T, Louis C, Takahashi S. Analysis of Notch1 signaling in mammalian sperm development. BMC Res Notes. 2023 Jun 19;16(1):108. doi: 10.1186/s13104-023-06378-z.

  17. Fuseya S, Izumi H, Hamano A, Murakami Y, Suzuki R, Koiwai R, Hayashi T, Kuno A, Takahashi S, Kudo T. Reduction in disialyl-T antigen levels in mice deficient for both St6galnac3 and St6galnac4 results in blood filling of lymph nodes. Sci Rep. 2023 Jun 29;13(1):10582. doi: 10.1038/s41598-023-37363-y.

  18. Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H. Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function. Cell Rep. 2023 Aug 1:112914. doi: 10.1016/j.celrep.2023.112914.

  19. Yoshihara M, Takahashi S. Recent advances in in situ Notch signaling measurement. Front Cell Dev Biol. 2023 Jul 28;11:1244105. doi: 10.3389/fcell.2023.1244105.

  20. Shimizu R, Hirano I, Hasegawa A, Suzuki M, Otsuki A, Taguchi K, Katsuoka F, Uruno A, Suzuki N, Yumoto A, Okada R, Shirakawa M, Shiba D, Takahashi S, Suzuki T, Yamamoto M. Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice. Commun Biol. 2023 Aug 25;6(1):875. doi: 10.1038/s42003-023-05251-w.

  21. Tamari T, Ikeda Y, Morimoto K, Kobayashi K, Mizuno-Iijima S, Ayabe S, Kuno A, Mizuno S, Yoshiki A. A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation. Biol Open. 2023 Sep 15;12(9):bio059970. doi: 10.1242/bio.059970. Epub 2023 Aug 25. PMID: 37623822.

  22. Fujino M, Ojima M, Takahashi S. Exploring Large MAF Transcription Factors: Functions, Pathology, and Mouse Models with Point Mutations. Genes 2023, 14, 1883. https://doi.org/10.3390/genes14101883.

  23. Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani KI, Ema M. Null mutation of exocyst complex component 3-like does not affect vascular development in mice. Exp Anim. 2023 Sep 1. doi: 10.1538/expanim.23-0105.

  24.  Koike S, Keino-Masu K, Tanimoto Y, Takahashi S, Masu M. The autotaxin-LPA axis promotes membrane trafficking and secretion in yolk sac visceral endoderm cells. Biol Open. 2023 Nov 15;12(11):bio060081. doi: 10.1242/bio.060081.

  25. Tamura R, Sabu Y, Mizuno T, Mizuno S, Nakano S, Suzuki M, Abukawa D, Kaji S, Azuma Y, Inui A, Okamoto T, Shimizu S, Fukuda A, Sakamoto S, Kasahara M, Takahashi S, Kusuhara H, Zen Y, Ando T, Hayashi H. Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis. Nat Commun. 2023 Nov 21;14(1):6763. doi: 10.1038/s41467-023-42424-x.

  26. Kawamata T, Wakimoto A, Nishikawa T, Ikezawa M, Hamada M, Inoue Y, Kulathunga K, Salim FN, Kanai M, Nishino T, Gentleman K, Liu C, Mathis BJ, Obana N, Fukuda S, Takahashi S, Taya Y, Sakai S, Hiramatsu Y. Natto consumption suppresses atherosclerotic plaque progression in LDL receptor-deficient mice transplanted with iRFP-expressing hematopoietic cells. Sci Rep. 2023 Dec 18;13(1):22469. doi: 10.1038/s41598-023-48562-y. PMID: 38110459.

  27. Yoshihara M, Nakayama T, Takahashi S. Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver. BMC Research Notes. 2023.16:379 doi.org/10.1186/s13104-023-06674-8.