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Research

Produce genetically modified Mice

Tracing the Protein-Protein Binding Relationship:
We aim to investigate the pathogenic mechanisms of cardiac and psychiatric diseases by generating and analyzing iBioID mice, in which the in vivo protein-protein network can be characterized.
USP46 PRMT1 Tracing ProteinNetworks in vivo.
Related Paper[1]

Visualizing three germ layers formation:
To elucidate the molecular mechanism of three germ layers, the most important process in forming the body, we have established triple fluorescent reporter gene knock-in mice and embryonic stem (ES) cells, and are analyzing their characteristics and conducting applied research.

Related Paper[1]

Identify and classify genome edited mutant sequences:
We have developed a new rapid and accurate genetic inspection method that can comprehensively identify genome-edited sequences introduced at target chromosomal sites by machine learning and long-read sequencer.
We are conducting research to apply this technology to the analysis of complex and intricate genome editing outcomes.
NanoporeSequencer CRISPR-Cas9
Related Papers[1][2]

Revealing Unknown Life Phenomena with Unique Genetically Modified Mice

Reproductive isolation genes controlling evolution:
Hybrids born from crossbreeding between different species often exhibit male infertility. We aim to identify the genes that control this reproductive isolation phenomenon by our original multiple mutagenesis method.
Tiger Lion breeding Male Infertility Hybrid♂
Related Paper[1]

Intracellular vesicle trafficking and germ cell maturation:
We found that the Exoc1 gene, which regulates intracellular protein transport, is essential for spermatogenesis.
Wild-Type Exoc1 null Normal syncitium aggregatedsyncitium differentiation dysdifferentiation Sperm Azoospermia
Related Paper[1]

ナビゲーション

バナースペース

Laboratory Animal Science

〒305-8575
Tennodai 1-1-1,Tsukuba, Ibaraki,
Laboratory Animal Resource Center
B building, 2nd floor

TEL +81-29-853-3385