Produce genetically modified Mice

Tracing the Protein-Protein Binding Relationship:
We aim to investigate the pathogenic mechanisms of cardiac and psychiatric diseases by generating and analyzing iBioID mice, in which the in vivo protein-protein network can be characterized.

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Visualizing three germ layers formation:
To elucidate the molecular mechanism of three germ layers, the most important process in forming the body, we have established triple fluorescent reporter gene knock-in mice and embryonic stem (ES) cells, and are analyzing their characteristics and conducting applied research.

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Identify and classify genome edited mutant sequences:
We have developed a new rapid and accurate genetic inspection method that can comprehensively identify genome-edited sequences introduced at target chromosomal sites by machine learning and long-read sequencer.
We are conducting research to apply this technology to the analysis of complex and intricate genome editing outcomes.

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Revealing Unknown Life Phenomena with Unique Genetically Modified Mice

Reproductive isolation genes controlling evolution:
Hybrids born from crossbreeding between different species often exhibit male infertility. We aim to identify the genes that control this reproductive isolation phenomenon by our original multiple mutagenesis method.

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Intracellular vesicle trafficking and germ cell maturation:
We found that the Exoc1 gene, which regulates intracellular protein transport, is essential for spermatogenesis.

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