Publications

Paper & Review

Sakurai M, Ishitsuka K, Ito R, Wilkinson AC, Kimura T, Mizutani E, Nishikii H, Sudo K, Becker HJ, Takemoto H, Sano T, Kataoka K, Takahashi S, Nakamura Y, Kent DG, Iwama A, Chiba S, Okamoto S, Nakauchi H, Yamazaki S.
Chemically defined cytokine-free expansion of human haematopoietic stem cells.
Nature 2023 Feb

Abstract on PubMed

Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M.
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Nature 2022 Nov

Abstract on PubMed

Che JLC, Bode D, Kucinski I, Cull AH, Bain F, Becker HJ, Jassinskaja M, Barile M, Boyd G, Belmonte M, Zeng AGX, Igarashi KJ, Rubio-Lara J, Shepherd MS, Clay A, Dick JE, Wilkinson AC, Nakauchi H, Yamazaki S,
Göttgens B, Kent DG. Identification and characterization of in vitro expanded hematopoietic stem cells.
EMBO Rep 2022 Aug

Abstract on PubMed

Itokawa N, Oshima M, Koide S, Takayama N, Kuribayashi W, Nakajima-Takagi Y, Aoyama K, Yamazaki S, Yamaguchi K, Furukawa Y, Eto K, Iwama A.
Epigenetic traits inscribed in chromatin accessibility in aged hematopoietic stem cells.
Nat Commun 2022 May

Abstract on PubMed

Osaki J, Yamazaki S, Hikita A, Hoshi K
Hematopoietic progenitor cells specifically induce a unique immune response in dental pulp under conditions of systemic inflammation.
Heliyon. 2022 Feb

Abstract on PubMed

Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M.
iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma.
Cancer Immunol Res. 2021 Oct

Abstract on PubMed

Harada S, Ando M, Ando J, Ishii M, Yamaguchi T, Yamazaki S, Toyota T, Ohara K, Ohtaka M, Nakanishi M, Shin C, Ota Y, Nakashima K, Ohshima K, Imai C, Nakazawa Y, Nakauchi H, Komatsu N
Dual-antigen targeted iPSC-derived chimeric antigen receptor-T cell therapy for refractory lymphoma.
Mol Ther. 2021 Oct

Abstract on PubMed

Sudo K, Yamazaki S, Wilkinson AC, Nakauchi H, Nakamura Y.
Polyvinyl alcohol hydrolysis rate and molecular weight influence human and murine HSC activity ex vivo.
Stem Cell Res. 2021 Oct

Abstract on PubMed

Ochi K, Morita M, Wilkinson AC, Iwama A, Yamazaki S.
Non-conditioned bone marrow chimeric mouse generation using culture-based enrichment of hematopoietic stem and progenitor cells.
Nat Commun. 2021 Jun

Abstract on PubMed

Takahashi-Kobayashi M, Usui J, Yaguchi M, Yamazaki S, Kawamura T, Kaneko S, Seshan SV, Yamagata K.
Immunohistological score of transcription factor 21 had a positive correlation with its urinary excretion and proteinuria in immunoglobulin A nephropathy.
Histol Histopathol. 2021 Jul

Abstract on PubMed

Kuribayashi W, Oshima M, Itokawa N, Koide S, Nakajima-Takagi Y, Yamashita M, Yamazaki S, Rahmutulla B, Miura F, Ito T, Kaneda A, Iwama A.
Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche
J Exp Med. 2021 Mar

Abstract on PubMed

Zhong C, Kayamori K, Koide S, Shinoda D, Oshima M, Nakajima-Takagi Y, Nagai Y, Mimura N, Sakaida E, Yamazaki S, Iwano S, Miyawaki A, Ito R, Tohyama K, Yamaguchi K, Furukawa Y, Lennox W, Sheedy J, Weetall M, Iwama A.
Efficacy of the Novel Tubulin Polymerization Inhibitor PTC-028 for Myelodysplastic Syndrome
Cancer Sci. 2020 Oct

Abstract on PubMed

Omori S, Wang TW, Johmura Y, Kanai T, Nakano Y, Kido T, Susaki EA, Nakajima T, Shichino S, Ueha S, Ozawa M, Yokote K, Kumamoto S, Nishiyama A, Sakamoto T, Yamaguchi K, Hatakeyama S, Shimizu E, Katayama K, Yamada Y, Yamazaki S, Iwasaki K, Miyoshi C, Funato H, Yanagisawa M, Ueno H, Imoto S, Furukawa Y, Yoshida N, Matsushima K, Ueda HR, Miyajima A, Nakanishi M.
Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo
Cell Metab. 2020 Sep

Abstract on PubMed

Sato R, Reuter T, Hiranuma R, Shibata T, Fukui R, Motoi Y, Murakami Y, Tsukamoto H, Yamazaki S, Liu K, Saitoh SI, Latz E, Miyake K.
The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages
Int Immunol. 2020 Aug

Abstract on PubMed

Izawa K, Yamazaki S, Becker HJ, Bhadury J, Kakegawa T, Sakaguchi M, Tojo A.
Activated HoxB4-induced Hematopoietic Stem Cells from Murine Pluripotent Stem Cells via Long-Term Programming
Exp Hematol. 2020 Aug

Abstract on PubMed

Usui J, Yaguchi M, Yamazaki S, Takahashi-Kobayashi M, Kawamura T, Kaneko S, Seshan SV, Ronco P, Yamagata K.
Transcription factor 21 expression in injured podocytes of glomerular diseases
Sci Rep. 2020 Jul

Abstract on PubMed

Sakurai M, Takemoto H, Mori T, Okamoto S, Yamazaki S.
In vivo expansion of functional human hematopoietic stem progenitor cells by butyzamide
Int J Hematol. 2020 May

Abstract on PubMed

Wilkinson AC, Ishida R, Nakauchi H, Yamazaki S.
Long-term ex vivo expansion of mouse hematopoietic stem cells.
Nat Protoc. 2020 Jan

Abstract on PubMed

Nishimura T, Hsu I, Martinez-Krams DC, Nakauchi Y, Majeti R, Yamazaki S, Nakauchi H, Wilkinson AC.
Use of polyvinyl alcohol for chimeric antigen receptor T-cell expansion.
Exp Hematol. 2019 Dec

Abstract on PubMed

Hayashi Y, Goyama S, Liu X, Tamura M, Asada S, Tanaka Y, Fukuyama T, Wunderlich M, O'Brien E, Mizukawa B, Yamazaki S, Matsumoto A, Yamasaki S, Shibata T, Matsuda K, Sashida G, Takizawa H, Kitamura T.
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Nat Commun. 2019 Oct

Abstract on PubMed

Rizk M, Rizq O, Oshima M, Nakajima-Takagi Y, Koide S, Saraya A, Isshiki Y, Chiba T, Yamazaki S, Ma A, Jin J, Iwama A, Mimura N.
Akt inhibition synergizes with polycomb repressive complex 2 inhibition in the treatment of multiple myeloma.
Cancer Sci. 2019 Sep

Abstract on PubMed

Kato Y, Hou LB, Miyagi S, Nitta E, Aoyama K, Shinoda D, Yamazaki S, Kuribayashi W, Isshiki Y, Koide S, Si S, Saraya A, Matsuzaki Y, van Lohuizen M, Iwama A.
Bmi1 restricts the adipogenic differentiation of bone marrow stromal cells to maintain the integrity of the hematopoietic stem cell niche.
Exp Hematol. 2019 Aug

Abstract on PubMed

Ando M, Ando J, Yamazaki S, Ishii M, Sakiyama Y, Harada S, Honda T, Yamaguchi T, Nojima M, Ohshima K, Nakauchi H, Komatsu N.
Long-term eradication of extranodal NK/T cell lymphoma, nasal type, by induced pluripotent stem cell-derived Epstein-Barr virus-specific rejuvenated T cells in vivo.
Haematologica.. 2019 Jul

Abstract on PubMed

Adam C. Wilkinson, Reiko Ishida, Misako Kikuchi, Kazuhiro Sudo, Maiko Morita, Ralph Valentine Crisostomo, Ryo Yamamoto, Kyle M. Loh, Yukio Nakamura, Motoo Watanabe, Hiromitsu Nakauchi, Satoshi Yamazaki
Long term ex vivo hematopoietic stem cell expansion allows nonconditioned transplantation
Nature. 2019 May

Abstract on PubMed

Shiraishi K, Shichino S, Ueha S, Nakajima T, Hashimoto S, Yamazaki S, Matsushima K.
Mesenchymal-Epithelial Interactome Analysis Reveals Essential Factors Required for Fibroblast-Free Alveolosphere Formation.
iScience. 2019 Jan

Abstract on PubMed

Hamanaka S, Umino A, Sato H, Hayama T, Yanagida A, Mizuno N, Kobayashi T, Kasai M, Suchy FP, Yamazaki S, Masaki H, Yamaguchi T, Nakauchi H.
Generation of Vascular Endothelial Cells and Hematopoietic Cells by Blastocyst Complementation.
Stem Cell Reports. 2018 Oct

Abstract on PubMed

Asada S, Goyama S, Inoue D, Shikata S, Takeda R, Fukushima T, Yonezawa T, Fujino T, Hayashi Y, Kawabata KC, Fukuyama T, Tanaka Y, Yokoyama A, Yamazaki S, Kozuka-Hata H, Oyama M, Kojima S, Kawazu M, Mano H, Kitamura T.
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis.
Nat Commun. 2018 Jul

Abstract on PubMed

Wilkinson AC, Yamazaki S.
The hematopoietic stem cell diet.
Int J Hematol. 2018 Jun

Abstract on PubMed

Tadokoro Y, Hoshii T, Yamazaki S, Eto K, Ema H, Kobayashi M, Ueno M, Ohta K, Arai Y, Hara E, Harada K, Oshima M, Oshima H, Arai F, Yoshimura A, Nakauchi H, Hirao A.
Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.
Cell Stem Cell. 2018 May

Abstract on PubMed

Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, Iwama A.
Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells.
Exp Hematol. 2018 Apr

Abstract on PubMed

Wilkinson AC, Morita M, Nakauchi H, Yamazaki S.
Branched-chain amino acid depletion conditions bone marrow for hematopoietic stem cell transplantation avoiding amino acid imbalance-associated toxicity.
Exp Hematol. 2018 Apr

Abstract on PubMed

Kon A, Yamazaki S, Nannya Y, Kataoka K, Ota Y, Nakagawa MM, Yoshida K, Shiozawa Y, Morita M, Yoshizato T, Sanada M, Nakayama M, Koseki H, Nakauchi H, Ogawa S.
Physiological Srsf2 P95H expression causes impaired hematopoietic stem cell functions and aberrant RNA splicing in mice.
Blood. 2018 Feb

Abstract on PubMed

Tsukada M, Ota Y, Wilkinson AC, Becker HJ, Osato M, Nakauchi H, Yamazaki S.
In Vivo Generation of Engraftable Murine Hematopoietic Stem Cells by Gfi1b, c-Fos, and Gata2 Overexpression within Teratoma.
Stem Cell Reports. 2017 Oct

Abstract on PubMed

Adhesion patterning by a novel air-lock technique enables localization and in-situ real-time imaging of reprogramming events in one-to-one electrofused hybrids.
Sakamoto S, Okeyo KO, Yamazaki S, Kurosawa O, Oana H, Kotera H, Washizu M.
Biomicrofluidics. 2016 Oct 27;10(5):054122

Abstract on PubMed

Yuki Taya, Yasunori Ota, Adam C Wilkinson, Ayano Kanazawa, Hiroshi Watarai, Masataka Kasai, Hiromitsu Nakauchi and Satoshi Yamazaki.
Depleting dietary valine permits nonmyeloablative mouse hematopoietic stem cell transplantation. Science. Oct 20, 2016

Pre-transplantation blockade of TNF-α-mediated oxygen species accumulation protects hematopoietic stem cells.
Ishida T, Suzuki S, Lai CY, Yamazaki S, Kakuta S, Iwakura Y, Nojima M, Takeuchi Y, Higashihara M, Nakauchi H, Otsu M.
Stem Cells. 2016 Oct 18. doi: 10.1002/stem.2524.

Abstract on PubMed

Koide S, Oshima M, Takubo K, Yamazaki S, Nitta E, Saraya A, Aoyama K, Kato Y, Miyagi S, Nakajima-takagi Y, Chiba T, Matsui H, Arai F, Suzuki Y, Kimura H, Nakauchi H, Suda T, Shinkai Y, Iwama A. Setdb1 maintains hematopoietic stem and progenitor cells by restricting the ectopic activation of non-hematopoietic genes. Blood. Jun 14 , 2016

Abstract on PubMed

Chen JY, Miyanishi M, Wang SK, Yamazaki S, Shnha R, Kao KS, Seita J, Sahoo D, Nakauchi H, Weissman IL. Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenyous perivascular niche. Nature. 530(7589):223-7, 2016.

Abstract on PubMed

Ando M, Nishimura T, Yamazaki S, Yamaguchi T, Kawana-Tachikawa A, Hayama T, Nakauchi Y, Ando J, Ota Y, Takahashi S, Nishimura K, Ohtaka M, Nakanishi M, Miles JJ, Burrows SR, Brenner MK, Nakauchi H. A Safeguard System for Induced Pluripotent Stem Cell Derived Rejuvenated T Cell Therapy. Stem Cell Reports. 5(4): 597-608, 2015.

Abstract on PubMed

Ishida T, Yamazaki S, Nakauchi H, Higashihara M, Otsu M. Reactive oxygen species in hematopoietic stem cells affect culture outcome under inflammatory conditions. Open Journal of Hematology. 6: 6-7, 2015.

Okeyo KO, Kurosawa O, Yamazaki S, Oana H, Kotera H, Nakauchi H, Washizu M. Cell Adhesion Minimization by a Novel Mesh Culture Method Mechanically Directs Trophoblast Differentiation and Self-Assembly Organization of Human Pluripotent Stem Cells. Tissue Eng Part C Methods. 21(10):1105-15, 2015.

Nakauchi Y, Yamazaki S*, Napier C S, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H. (*Correspondence author) Effective treatment against severe Graft-versus-Host Disease with allele-specific anti-HLA monoclonal antibody in a humanized-mouse model. Exp Hematol. 43(2):79-88, 2015.

Ito T, Sendai Y, Yamazaki S, Seki-Soma M, Hirose K, Watanabe M, Fukawa K, Nakauchi H. Generation of recombination activating gene-1-deficient neonatal piglets: a model of T and B cell deficient severe combined immune deficiency. PLoS One. 9(12):e113833, 2014.

Hayama T, Yamaguchi T, Kato-Itoh M, Hamanaka S, Kawarai M, Sanbo M, Tamura C, Lee YS, Yanagida A, Murayama H, Mizuno N, Umino A, Sato H, Yamazaki S, Masaki H, Kobayashi T, Hirabayashi M, Nakauchi H. Generation of Mouse Functional Oocytes in Rat by Xeno-Ectopic Transplantation of Primorial Germ Cells. Biol Reprod. 91(4):89, 2014.

Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimisu R, Nakauchi H, Yamamoto T, Oshimura M. Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies. Sci Rep. 4: 6136, 2014.

Ito K, Yamazaki S, Yamamoto R, Tajima Y, Yanagida A, Kobayashi T, Kato-Itoh M, Kakuta S, Iwakura Y, Nakauchi H, Kamiya A. Gene Targeting Study Reveals Unexpected Expression of Brain Expressed X-linked 2 in Endocrine and Tissue Stem/projenitor Cells in Mice. J Biol Chem. 289(43):29892-911, 2014.

Okamoto N, Aoto T, Uhara H, Yamazaki S, Akutsu H, Umezawa A, Nakauchi H, Miyachi Y, Saida T, Nishimura EK. A melanocyte-melanoma precursor niche in sweat glands of volar skin. Pigment Cell Melanoma. 27(6):1039-50, 2014.

Sakurai M, Kunimoto H, Watanabe N, Fukuchi Y, Yuasa S, Yamazaki S, Nishimura T, Sadahira K, Fukuda K, Okano H, Nakauchi H, Morita Y, Matsumura I, Kudo K, Ito E, Ebihara Y, Tsuji K, Harada Y, Harada H, Okamoto S, Nakajima H. Impaired hematopoietic differentiation of RUNX1 mutated induced pluripotent stem cells derived from FPD/AML patients. Leukemia. 28(12):2344-54, 2014.

Ieyasu A, Tajima Y, Shimba S, Nakauchi H, Yamazaki S*. (*Correspondence author) Clock gene Bmal1 is dispensable for intrinsic properties of murine hematopoietic stem cells. J Negat Biomed. 13: 4, 2014.

Miyagi S, Koide S, Saraya A, Wendt GR, Oshima M, Konuma T, Yamazaki S, Mochizuki-Kashio M, Nakajima-Takagi Y, Wang C, Chiba T, Kitabayashi I, Nakauchi H, Iwama A. The TIF1beta-HP1 System Maintains Transcriptional Integrity of Hematopoietic Stem Cells. Stem Cell Reports. 2(2):145-52, 2014.

Lai CY, Yamazaki S, Okabe M, Suzuki S, Maeyama Y, Iimura Y, Onodera M, Kakuta S, Iwakura Y, Nojima M, Otsu M, Nakauchi H. Stage-specific roles for Cxcr4 signaling in murine hematopoietic stem/progenitor cells in the process of bone marrow repopulation. Stem cells. 32(7):1929-42, 2014.

Hirose S, Takayama N, Nakamura S, Nagasawa K, Ochi K, Hirata S, Yamazaki S, Yamaguchi T, Otsu M, Sano S, Takahashi N, Sawaguchi A, Ito M, Kato T, Nakauchi H, Eto K. Immortalization of erythroblast by c-Myc and Bcl-xl enables large-scale erythrocyte production from human pluripotent stem cells. Stem Cell Reports. 1(6):499-508, 2013.

Yamazaki S*, Suzuki N, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M and Nakauchi H. (*Correspondence author) Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation. Mol Ther. 21(7): 1424-31, 2013.

Nakamura S, Oshima M, Yuan J, Saraya A, Miyagi S, Konuma T, Yamazaki S, Osawa M, Nakauchi H, Koseki H and Iwama A. Bmi-1 confers resistance to oxidative stress on hematopoietic stem cells. PLoS One. 7(5):e36209, 2012.

Yamaguchi T, Hamanaka S, Kamiya A, Okabe M, Kawarai M, Wakiyama Y, Umino A, Hayama T, Sato H, Lee YS, Kato-Itoh M, Kobayashi T, Yamazaki S and Nakauchi H.
Development of an all in one inducible lentiviral vector for gene specific analysis of reprogramming. PLoS One. 7(7): e41007, 2012.

Oguro H, Yuan J, Tanaka S, Miyagi S, Mochizuki-Kashio M, Ichikawa H, Yamazaki S, Koseki H, Nakauchi H and Iwama A. Lethal myelofibrosis induced by Bmi-1 deficient hematopoietic stem cells unveils a tumor suppressor function of the polycomb group genes. J Exp Med. 209(3):445-454, 2012.

Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, and Nakauchi H. Non-myelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell. 23, 1146-1158, 2011.

Suzuki N, Yamazaki S, Ema H, Yamaguchi T, Nakauchi H, and Nakauchi H. Homeostasis of hematopoietic stem cells regulated by the myeloproliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xl. Exp Hematol. 40, 166-174, 2011.

Hamanaka S, Yamaguchi T, Kobayashi T, Kato-Itoh M, Yamazaki S, Sato H, Umino A, Wakiyama Y, Arai M, Sanbo M, Hirabayashi M, Nakauchi H. Generation of germline-competent rat induced pluripotent stem cells. PLoS One. 6(7):e22008, 2011.

Tanimura S, Tadokoro Y, Inomata K, Binh NT, Nishie W, Yamazaki S, Nakauchi H, Tanaka Y, McMillan JR, Sawamura D, Yancey K, Shimizu H, Nishimura EK. Hair follicle stem cells provide a functional niche for melanocyte stem cells. Cell Stem Cell. 8(2):177-87, 2011.

Nakahata S, Yamazaki S, Nakauchi H, Morishita K. Downregulation of ZEB1 and overexpression of Smad7 contribute to resistance to TGF-beta1-mediated growth suppression in adult T-cell leukemia/lymphoma. Oncogene. 29(29):4157-69, 2010.

Yamanishi Y, Kitaura J, Izawa K, Kaitani A, Komeno Y, Nakamura M, Yamazaki S, Enomoto Y, Oki T, Akiba H, Abe T, Komori T, Morikawa Y, Kiyonari H, Takai T, Okumura K, Kitamura T. TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury. J Exp Med. 207(7): 1501-11, 2010.

Oguro H, Yuan J, Ichikawa H, Ikawa T, Yamazaki S, Kawamoto H, Nakauchi H, Iwama A. Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1. Cell Stem Cell. 6(3):279-86, 2010.

Takizawa H, Nishimura S, Takayama N, Oda A, Nishikii H, Morita Y, Kakinuma S, Yamazaki S, Okamura S, Tamura N, Goto S, Sawaguchi A, Manabe I, Takatsu K, Nakauchi H, Takaki S, Eto K. Lnk regulates integrin alphaIIbbeta3 outside-in signaling in mouse platelets, leading to stabilization of thrombus development in vivo. J Clin Invest. 120(1):179-90, 2009.

Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S. Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature. 460(7257):904-8, 2009.

Yamazaki S, Suzuki N, Saito T, Ishii Y, Takiguchi M, Nakauchi H, Watanabe N. A rapid and efficient strategy to generate allele-specific anti-HLA monoclonal antibodies. J Immunol Methods. 343(1):56-60, 2009.

Yamazaki S, Iwama A, Takayanagi S, Eto K, Ema H, Nakauchi H. TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood. 113(6):1250-6, 2008.

Yamanishi Y, Kitaura J, Izawa K, Matsuoka T, Oki T, Lu Y, Shibata F, Yamazaki S, Kumagai H, Nakajima H, Maeda-Yamamoto M, Tybulewicz VL, Takai T, Kitamura T. Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood. 111(2):688-98, 2008.

Miyamoto K, Araki KY, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, Hirao A. Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 1(1):101-12, 2007.

Ema H, Morita Y, Yamazaki S, Matsubara A, Seita J, Tadokoro Y, Kondo H, Takano H, Nakauchi H. Adult mouse hematopoietic stem cells: purification and single-cell assays. Nat Protoc. 1(6): 2979-87, 2006.

Seita J, Ema H, Ooehara J, Yamazaki S, Tadokoro Y, Yamasaki A, Eto K, Takaki S, Takatsu K, Nakauchi H. Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction. Proc Natl Acad Sci U S A. 104(7): 2349-54, 2007.

Yamazaki S, Iwama A, Takayanagi S, Morita Y, Eto K, Ema H, Nakauchi H. Cytokine signals modulated via lipid rafts mimic niche signals and induce hibernation in hematopoietic stem cells. EMBO J. 25(15):3515-23, 2006.

Morita Y, Ema H, Yamazaki S, Nakauchi H. Non-side-population hematopoietic stem cells in mouse bone marrow. Blood. 108(8):2850-6, 2006.

Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H. Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood. 107(11):4317-25, 2006.

Usui J, Osawa M, Yamazaki S, Morita Y, Koyama A, Nakauchi H. Identification of immature podocyte specific antigen using retrovirus-mediated gene transfer and cell sorting. Clin Exp Nephrol. 9(4):292-6, 2005.

Matsubara A, Iwama A, Yamazaki S, Furuta C, Hirasawa R, Morita Y, Osawa M, Motohashi T, Eto K, Ema H, Kitamura T, Vestweber D, Nakauchi H. Endomucin, a CD34-like sialomucin, marks hematopoietic stem cells throughout development. J Exp Med. 202(11):483-92, 2005.

Tahara-Hanaoka S, Shibuya K, Onoda Y, Zhang H, Yamazaki S, Miyamoto A, Honda S, Lanier LL, Shibuya A. Functional characterization of DNAM-1 (CD226) interaction with its ligands PVR (CD155) and nectin-2 (PRR-2/CD112). Int Immunol. 16(4):533-8, 2004.

Yotsumoto K, Okoshi Y, Shibuya K, Yamazaki S, Tahara-Hanaoka S, Honda S, Osawa M, Kuroiwa A, Matsuda Y, Tenen DG, Iwama A, Nakauchi H, Shibuya A. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J Exp Med. 198(2):223-33, 2003.

Conference Presentation

Yamazaki S
Hematopoietic stem cell expansion by ex vivo. US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies、Hawaii、2019

Yamazaki S
造血幹細胞の増幅技術開発と応用. The Japanese Society For Regenerative Medicine、Kobe、2018

Yamazaki S
Understanding of bone marrow environment and hematopoietic stem cell regulateon. Japanese Society of Hematology、Osaka、2018

Activity in the lab