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Publicasions

2017

  • Simple generation of hairless mice for in vivo imaging.
    Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami K, Sugiyama F.
    Exp. Anim. http://doi.org/10.1538/expanim.17-0049
  • Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.
    Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, Yamamoto M.
    Cell Rep. 2017 Feb 21;18(8):2030-2044. doi: 10.1016/j.celrep.2017.01.064.
  • SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.
    Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
    Stem Cell Reports. doi.org/10.1016/j.stemcr.2017.01.006.
  • Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.
    Ishimaru T, Ishida J, Kim JD, Mizukami H, Hara K, Hashimoto M, Yagami KI, Sugiyama F, Fukamizu A
    J Biochem. 2016 Dec 21. pii: mvw095. doi: 10.1093/jb/mvw095.



2016

  • Forward-genetics analysis of sleep in randomly mutagenized mice
    Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M
    Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142.
  • Bio-active polymer implants to adipose tissue as in situ source of reprogramming cells.
    Mikhailov A, Sugiyama F, Mizuno-Iijima S, Sankai Y.
    Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4169-4172. doi: 10.1109/EMBC.2016.7591645.
  • Generation of CRISPR/Cas9-mediated bicistronic knock-in Ins1-cre driver mice
    Hasegawa Y, Hoshino Y, Abdelaziz E. Ibrahim, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F
    Exp Anim. 2016 Jul 29;65(3):319-27. doi: 10.1538/expanim.16-0016.
  • Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.
    Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F.
    Genesis. 2016 Jul;54(7):389-97. doi: 10.1002/dvg.22944.
  • Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
    Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, S.I. Han, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H
    Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857.
  • Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers.
    Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata, W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazak Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S
    Nature. 2016 May 23;534(7607):402-6. doi: 10.1038/nature18294.
  • H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
    Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami KI, Tanaka M, Fukuda K.
    Stem Cell Reports. 2016 May 20. pii: S2213-6711(16)30040-6.
  • Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.
    Shimbo M1, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami KI, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.
    Exp Anim. 2016 May 20;65(2):175-87. doi: 10.1538/expanim.15-0077.
  • Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice
    Ohmi Y, Ise W, Harazono A, Takamura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Shuting Ji, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K
    Nat Commun. 2016 Apr 5;7:11205. doi: 10.1038/ncomms11205.
  • Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.
    Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD.
    J Clin Invest. 2016 Mar 1;126(3):865-78. doi: 10.1172/JCI83894.
  • β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
    Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S.
    PLoS One. 2016 Feb 22;11(2):e0150010. doi: 10.1371/journal.pone.0150010. eCollection 2016.



2015

  • Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes.
    Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T.
    Mol Cell Biol. 2015 Nov 15;35(22):3841-53.
  • Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
    Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Sugiyama F, Yagami KI, Takahashi S, Okuda A, Okazaki Y.
    Stem Cells. 2015 Nov 2. doi: 10.1002/stem.2243.
  • Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
    Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh TT, Mizuno-Iijima S, Hasegawa Y, Takahashi S, Sugiyama F, Yagami K.
    Sci Rep. 2015 Sep 8;5:13632.
  • Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.
    Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, Fukamizu A.
    PLoS One. 2015 Jun 24;10(6):e0129484.
  • 遺伝子改変マウスとゲノム編集 水野 聖哉. 生物工学会誌 (15年) 93巻12号
  • CRISPR/Cas9 (ゲノム編集). 水野 聖哉. 炎症と免疫 (15年) 23巻5号
  • 脳梁形成機構. 水野 聖哉, Dinh TT, 杉山 文博. Clinical Neuroscience Vol.33 (15年) 04月号



2014

  • A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice.
    Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A.
    J Recept Signal Transduct Res. 2014 Oct;34(5):401-9.
  • p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.
    Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
    J Recept Signal Transduct Res. 2014 Aug;34(4):299-306.
  • Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.
    Mizuno S, Tra DT, Kato K, Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, and Yagami K.
    Mamm Genome. 2014 Aug;25(7-8):327-34.
  • Truncated Cales1 causes agenesis of the corpus callosum in mice.
    Mizuno S, Tra DT, Mizobuchi A, Iseki H, Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K.
    Lab Invest. 2014 Mar;94(3):321-30.
  • Role of retinoic acid and fibroblast growth factor 2 in neural differentiation from cynomolgus monkey (macaca fascicularis) embryonic stem cells.
    Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T.
    Comp Med. 2014 Apr;64(2):140-7.
  • Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination.
    Hasegara Y, Daitoku Y, Mizuno S, Tanimoto Y, Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K.
    Exp Anim. 2014;63(2):183-91.



2013

  • Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.
    Hasegara Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K.
    Exp Anim. 2013;62(4):295-304.
  • Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
    Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A.
    Endocrinology. 2013 Feb;154(2):597-602.



2012

  • Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.
    Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami K, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K.
    Free Radic Biol Med. 2012 Dec 15;53(12):2256-62.
  • Short-term suppression of the renin-angiotensin system in mice associated with hypertension during pregnancy.
    Ishimaru T, Ishida J, Nakamura S, Hashimoto M, Matsukura T, Nakamura A, Kunita S, Sugiyama F, Yagami K, Fukamizu A.
    Mol Med Rep. 2012 Jul;6(1):28-32.



Before 2011


バナースペース

Laboratory Animal Science

〒305-8575
Tennodai 1-1-1,Tsukuba, Ibaraki,
Laboratory Animal Resource Center
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TEL +81-29-853-3385