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Tracing the Protein-Protein Binding Relationship:
We aim to investigate the pathogenic mechanisms of cardiac and psychiatric diseases by generating and analyzing iBioID mice, in which the in vivo protein-protein network can be characterized.
Related Paper[1]
Visualizing three germ layers formation:
To elucidate the molecular mechanism of three germ layers, the most important process in forming the body, we have established triple fluorescent reporter gene knock-in mice and embryonic stem (ES) cells, and are analyzing their characteristics and conducting applied research.
Related Paper[1]
Identify and classify genome edited mutant sequences:
We have developed a new rapid and accurate genetic inspection method that can comprehensively identify genome-edited sequences introduced at target chromosomal sites by machine learning and long-read sequencer.
We are conducting research to apply this technology to the analysis of complex and intricate genome editing outcomes.
Related Papers[1][2]
Reproductive isolation genes controlling evolution:
Hybrids born from crossbreeding between different species often exhibit male infertility. We aim to identify the genes that control this reproductive isolation phenomenon by our original multiple mutagenesis method.
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Intracellular vesicle trafficking and germ cell maturation:
We found that the Exoc1 gene, which regulates intracellular protein transport, is essential for spermatogenesis.
Related Paper[1]
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Laboratory Animal Resource Center
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