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業績publicasions

2020

  • Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6.
    Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Kanzaki M, Mizuno S, Takahashi S, Fujimoto M, Okiyama N.
    Commun Biol. 2020 Oct 15;3(1):571. doi: 10.1038/s42003-020-01308-2.
  • Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development
    Hashimoto M, Kumabe A, Kim JD, Murata K, Sekizar S, Williams A, Lu W, Ishida J, Nakagawa T, Endo M, Minami Y, Fukamizu A.
    J. Neurochem First published: 16 August 2020 https://doi.org/10.1111/jnc.15149
  • Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.
    Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y.
    Genetics. 2020 Sep 2:genetics.303435.2020. doi: 10.1534/genetics.120.303435. Online ahead of print. PMID: 32878901
  • Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo.
    Hasan ASH, Dinh TTH, LE HT, Mizuno-Iijima S, Daitoku Y, Ishida M, Tanimoto Y, Kato K, Yoshiki A, Murata K, Mizuno S, Sugiyama F.
    Exp Anim. 2020 Aug 11. doi: 10.1538/expanim.20-0063. Online ahead of print. PMID: 32779618
  • Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction.
    Honda T, Takata Y, Cherasse Y, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M, Lazarus M, Oishi Y.
    iScience. 2020 Jun 4;23(6):101240. doi: 10.1016/j.isci.2020.101240. PMID: 3256315
  • Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules.
    Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S.
    Angew Chem Int Ed Engl. 2020 Jun 18. doi: 10.1002/anie.202005887. PMID: 32557993
  • Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.
    Morimoto K, Numata K, Daitoku Y, Hamada Y, Kobayashi K, Kato K, Suzuki H, Ayabe S, Yoshiki A, Takahashi S, Murata K, Mizuno S, Sugiyama F.
    Sci Rep. 2020 June 3;10:9060. https://doi.org/10.1038/s41598-020-65986-y
  • Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
    Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H.
    Sci Rep. 2020 May 26;10(1):8676. doi: 10.1038/s41598-020-65647-0.
  • Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes.
    Mizuno-Iijima S, Ayabe S, Kato K, Matoba S, Ikeda Y, Dinh TTH, Le HT, Suzuki H, Nakashima K, Hasegawa Y, Hamada Y, Tanimoto Y, Daitoku Y, Iki N, Ishida M, Elsayed Ibrahim Elzeftawy A, Nakashiba T, Hamada M, Murata K, Miwa Y, Okada-Iwabu M, Iwabu M, Yagami KI, Ogura A, Obata Y, Takahashi S, Mizuno S, Yoshiki A, Sugiyama F
    Methods. 2020 Apr 22. pii: S1046-2023(19)30328-7. doi: 10.1016/j.ymeth.2020.04.007.
  • Generation of B6-Ddx4em1(CreERT2)Utr, a Novel CreERT2 Knock-In Line, for Germ Cell Lineage by CRISPR/Cas9.
    Le HT, Hasegawa Y, Daitoku Y, Kato K, Miznuo-Iijima S, Dinh TTH, Kuba Y, Osawa Y, Mikami N, Morimoto K, Ayabe S, Tanimoto Y, Murata K, Yagami KI, Takahashi S, Mizuno S, Sugiyama F.
    Genesis. 2020 Jul;58(7):e23367. doi: 10.1002/dvg.23367. Epub 2020 Apr 15. PMID: 32293787.
  • c-Maf deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells.
    Fujino M, Tagami A, Ojima M, Mizuno S, Abdellatif AM, Kuno A, Takahashi S
    Exp Anim. 2020 Jan 21. doi: 10.1538/expanim.19-0137

2019

  • Modulation of methotrexate-induced intestinal mucosal injury by dietary factors.
    Higuchi T , Yoshimura M, Oka S, Tanaka K, Naito T, Yuhara S, Warabi E, Mizuno S, Ono M, Takahashi S, Tohma S, Tsuchiya N, Furukawa H
    Hum Exp Toxicol.2019 Dec 26 https://doi.org/10.1177/0960327119896605
  • RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.
    Pang K, Park J, Ahn SG, Lee J, Park Y, Ooshima A, Mizuno S, Yamashita S, Park KS, Lee SY, Jeong J, Ushijima T, Yang KM, Kim SJ.
    Nat Commun2019 Dec 20;10(1):5805 doi:10.1038/s41467-019-13852-5
  • Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression.
    Browning J, Rooney M, Hams E, Takahashi S, Mizuno S, Sugiyama F, Fallon PG, Kelly VP.
    Mol Biol Rep.2019 Dec 6. doi: 10.1007/s11033-019-05204-9.
  • Clec10a regulates mite-induced dermatitis.
    Kanemaru K, Noguchi E, Tahara-Hanaoka S, Mizuno S, Tateno H, Denda-Nagai K, Irimura T, Matsuda H, Sugiyama F, Takahashi S, Shibuya K, Shibuya A.
    Sci Immunol.2019 Dec 6;4(42). pii: eaax6908. doi: 10.1126/sciimmunol.aax6908.
  • Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model.
    Chang YH, Katoh MC, Abdellatif AM, Xiafukaiti G, Elzeftawy A, Ojima M, Mizuno S, Kuno A, Takahashi S
    Exp Anim.2019 Dec 2. doi: 10.1538/expanim.19-0105.
  • Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720.
    Fukuda A, Honda S, Fujioka N, Sekiguchi Y, Mizuno S, Miwa Y, Sugiyama F, Hayashi Y, Nishimura K, Hisatake K
    PLoS One. 2019 Nov 15;14(11):e0225213.
  • Regulations of bile acid metabolism in mouse models with hydrophobic bile acid composition.
    Honda A, Miyazaki T, Iwamoto J, Hirayama T, Morishita Y, Monma T, Ueda H, Mizuno S, Sugiyama F, Takahashi S, Ikegami T.
    J Lipid Res. 2019 Oct 23. pii: jlr.RA119000395.
  • Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.
    Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G.
    Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2
  • Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
    Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S.
    J Clin Invest. 2019 Jul 23;130. pii: 121955.
  • Generation of bicistronic reporter knockin mice for visualizing germ layers.
    Suzuki H, Dinh TTH, Daitoku Y, Tanimoto Y, Kato K, Azami T, Ema M, Murata K, Mizuno S, Sugiyama F
    Exp Anim. 2019 Jun 13. doi: 10.1538/expanim.19-0031. [Epub ahead of print].
  • The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
    Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A.
    Blood. 2019 Mar 27. pii: blood.2019000468. doi: 10.1182/blood.2019000468.
  • KOnezumi: a web application for automating gene disruption strategies to generate knockout mice.
    Kuno A, Mizuno S, Takahashi S.
    Bioinformatics. 2019 Feb 6. doi: 10.1093/bioinformatics/btz090.
  • Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells.
    Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M.
    PLoS One. 2019 Jan 2;14(1):e0210060. doi: 10.1371/journal.pone.0210060. eCollection 2019.

2018

  • Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
    Kitadate Y, Jorg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshida S.
    Cell Stem Cell.2018 Dec 11. pii: S1934-5909(18)30549-6.
  • Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients.
    Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui T, Kanai M, Mizuno S, Morito N, Takahashi S.
    Exp Anim. 2018 Oct 26. doi: 10.1538/expanim.18-0093.
  • A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice.
    Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M
    Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 201810823.
  • Anti-Fractalkine Antibody Suppresses Joint Destruction by Inhibiting Migration of Osteoclast Precursors to the Synovium in Experimental Arthritis.
    Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T.
    Arthritis Rheumatol. 2018 Aug 6. doi: 10.1002/art.40688.
  • De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure Syndrome.
    Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K1, Tanaka H, Terui K, Sato T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto K, Ogawa S, Ito E.
    Am J Hum Genet. 2018. pii: S0002-9297(18)30247-7.
  • ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
    Mali GR, Yeyati PL, Mizuno S, Dodd DO, Tennant PA, Keighren MA, Zur Lage P, Shoemark A, Garcia-Munoz A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreisheim A, Jarman AP, Mill P.
    Elife. 2018 Jun 19;7. pii: e34389.
  • A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis with Duane Retraction Syndrome.
    Sato Y, Tsukaguchi H, Morita H, Higasa K, Tran MTN, Hamada M, Usui T, Morito N, Horita S, Hayashi T, Takagi J, Yamaguchi I, Nguyen HT, Harada M, Inui K, Maruta Y, Inoue Y, Koiwa F, Sato H, Matsuda F, Ayabe S, Mizuno S, Sugiyama F, Takahashi S, Yoshimura A.
    Kidney Int. 2018 May 17. pii: S0085-2538(18)30216-3.
  • Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis.
    Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M.
    Front Immunol. 2018 Jan 17;8:2017.

2017

  • Simple generation of hairless mice for in vivo imaging.
    Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami K, Sugiyama F.
    Exp Anim. 2017 Oct 30;66(4):437-445.
  • Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.
    Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, Yamamoto M.
    Cell Rep. 2017 Feb 21;18(8):2030-2044. doi: 10.1016/j.celrep.2017.01.064.
  • SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling in Mouse Spermatogenic Stem Cells.
    Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H, Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S.
    Stem Cell Reports. 2017 Mar 14;8(3):561-575..
  • Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1) in vascular endothelial cells.
    Ishimaru T, Ishida J, Kim JD, Mizukami H, Hara K, Hashimoto M, Yagami KI, Sugiyama F, Fukamizu A
    J Biochem. 2017 Mar 1;161(3):255-258.

2016

  • Forward-genetics analysis of sleep in randomly mutagenized mice
    Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M
    Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142.
  • Bio-active polymer implants to adipose tissue as in situ source of reprogramming cells.
    Mikhailov A, Sugiyama F, Mizuno-Iijima S, Sankai Y.
    Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4169-4172. doi: 10.1109/EMBC.2016.7591645.
  • Generation of CRISPR/Cas9-mediated bicistronic knock-in Ins1-cre driver mice
    Hasegawa Y, Hoshino Y, Abdelaziz E. Ibrahim, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F
    Exp Anim. 2016 Jul 29;65(3):319-27. doi: 10.1538/expanim.16-0016.
  • Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.
    Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F.
    Genesis. 2016 Jul;54(7):389-97. doi: 10.1002/dvg.22944.
  • Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated using a one-step CRISPR/Cas9 system
    Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, S.I. Han, Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone H, Takahashi S, Yamada N, Shimano H
    Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857.
  • Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers.
    Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata, W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazak Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S
    Nature. 2016 May 23;534(7607):402-6. doi: 10.1038/nature18294.
  • H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
    Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami KI, Tanaka M, Fukuda K.
    Stem Cell Reports. 2016 May 20. pii: S2213-6711(16)30040-6.
  • Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies.
    Shimbo M1, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa Y, Mizuno S, Yagami KI, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T, Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T, Kokubu Y, Noguchi TK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa M, Ito N, Takeda S, Takahashi S.
    Exp Anim. 2016 May 20;65(2):175-87. doi: 10.1538/expanim.15-0077.
  • Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice
    Ohmi Y, Ise W, Harazono A, Takamura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Shuting Ji, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K
    Nat Commun. 2016 Apr 5;7:11205. doi: 10.1038/ncomms11205.
  • Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs.
    Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD.
    J Clin Invest. 2016 Mar 1;126(3):865-78. doi: 10.1172/JCI83894.
  • β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
    Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S.
    PLoS One. 2016 Feb 22;11(2):e0150010. doi: 10.1371/journal.pone.0150010. eCollection 2016.

2015

  • Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes.
    Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T.
    Mol Cell Biol. 2015 Nov 15;35(22):3841-53.
  • Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells.
    Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto Y, Iijima S, Sugiyama F, Yagami KI, Takahashi S, Okuda A, Okazaki Y.
    Stem Cells. 2015 Nov 2. doi: 10.1002/stem.2243.
  • Peri-implantation lethality in mice carrying megabase-scale deletion on 5qc3.3 is caused by Exoc1 null mutation.
    Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh TT, Mizuno-Iijima S, Hasegawa Y, Takahashi S, Sugiyama F, Yagami K.
    Sci Rep. 2015 Sep 8;5:13632.
  • Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways.
    Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, Fukamizu A.
    PLoS One. 2015 Jun 24;10(6):e0129484.
  • 遺伝子改変マウスとゲノム編集 水野 聖哉. 生物工学会誌 (15年) 93巻12号
  • CRISPR/Cas9 (ゲノム編集). 水野 聖哉. 炎症と免疫 (15年) 23巻5号
  • 脳梁形成機構. 水野 聖哉, Dinh TT, 杉山 文博. Clinical Neuroscience Vol.33 (15年) 04月号

2014

  • A mouse renin distal enhancer is essential for blood pressure homeostasis in BAC-rescued renin-null mutant mice.
    Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A.
    J Recept Signal Transduct Res. 2014 Oct;34(5):401-9.
  • p38 Mitogen-activated protein kinase accelerates emphysema in mouse model of chronic obstructive pulmonary disease.
    Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y.
    J Recept Signal Transduct Res. 2014 Aug;34(4):299-306.
  • Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase gene by the CRISPR/Cas9 system.
    Mizuno S, Tra DT, Kato K, Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, and Yagami K.
    Mamm Genome. 2014 Aug;25(7-8):327-34.
  • Truncated Cales1 causes agenesis of the corpus callosum in mice.
    Mizuno S, Tra DT, Mizobuchi A, Iseki H, Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K.
    Lab Invest. 2014 Mar;94(3):321-30.
  • Role of retinoic acid and fibroblast growth factor 2 in neural differentiation from cynomolgus monkey (macaca fascicularis) embryonic stem cells.
    Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T.
    Comp Med. 2014 Apr;64(2):140-7.
  • Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive pancreatic beta cell-specific Cre-loxP recombination.
    Hasegara Y, Daitoku Y, Mizuno S, Tanimoto Y, Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K.
    Exp Anim. 2014;63(2):183-91.

2013

  • Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.
    Hasegara Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S, Sugiyama F, Yagami K.
    Exp Anim. 2013;62(4):295-304.
  • Effect of lactation on postpartum cardiac function of pregnancy-associated hypertensive mice.
    Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A.
    Endocrinology. 2013 Feb;154(2):597-602.

2012

  • Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.
    Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami K, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K.
    Free Radic Biol Med. 2012 Dec 15;53(12):2256-62.
  • Short-term suppression of the renin-angiotensin system in mice associated with hypertension during pregnancy.
    Ishimaru T, Ishida J, Nakamura S, Hashimoto M, Matsukura T, Nakamura A, Kunita S, Sugiyama F, Yagami K, Fukamizu A.
    Mol Med Rep. 2012 Jul;6(1):28-32.

2011年以前はこちら


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実験動物学研究室

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茨城県つくば市天王台1-1-1
筑波大学生命科学動物資源センター
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