メニュー

研究業績

2017年

  • Jiang, W., Ishino, Y., Hashimoto, H., Keino-Masu, K., Masu, M., Uchimura, K., Kadomatsu, K., Yoshimura, T., and Ikenaka, K. Sulfatase2 Modulates Fate Change from Motor Neurons to Oligodendrocyte Precursor Cells through Coordinated Regulation of Shh Signaling with Sulfatase1. Dev. Neurosci. 39, 361-374, 2017.
  • Terawaki, S., Fujita, S., Katsutani, T., Shiomi, K., Keino-Masu, K., Masu, M. Wakamatsu, K., Shibata, N., and Higuchi, Y. Structural basis for CCd1 auto-inhibition in the Wnt pathway through homomerization of the DIX domain. Sci. Rep. 10, 7739, 2017.
  • Okada, T., Keino-Masu, K., Nagamine, S., Kametani, F., Ohto, T., Hasegawa, M., van Kuppevelt, T.H., Kunita, S., Takahashi, S., and Masu, M. Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation. Sci. Rep. 7, 13847, 2017.

2016年

  • Takashima, Y., Keino-Masu, K., Yashiro, H., Hara, S., Suzuki, T., van Kuppevelt, T.H., Masu, M., and Nagata, M. Heparan Sulfate 6-O-EndoSulfatases, Sulf1 and Sulf2, Regulate Glomerular Integrity by Modulating Growth Factor Signaling. Am. J. Physiol.-Renal Physiol. 310, F395-408, 2016.
  • Masu, M. Proteoglycans and axon guidance: a new relationship between old partners. J. Neurochem. 139, 58-75, 2016.

2015年

  • Freeman, S.D., Keino-Masu, K., Masu, M., and Ladher, R.K. Expression of the heparan sulfate 6-O-endosulfatases, Sulf1 and Sul2, in the avian and mammalian inner ear suggests a role for sulfation in inner ear development. Dev. Dyn. 244, 168-180, 2015.

2013年

  • Akamatsu, M. Yamashita, T., Okada, T., Keino-Masu, K., Ishii, K., Kwak, S., Masu, M., and Tamaoka, A. A unique mouse model for investigating the properties of amyotrophic lateral sclerosis-associated protein TDP-43, by in utero electroporation. Neurosci. Res., 77. 234-241, 2013 
  • Masu, M., Koike, S., Okada, T., and Keino-Masu, K. Studies on autotaxin signaling in endocytic vesicle biogenesis and embryonic development using whole embryo culture and electroporation. In: Lysophospholipid Receptors: Signaling and Biochemistry. (Ed. by J. Chun et al.), John Wiley & Son Inc. Hoboken, NJ, USA.chapter 7, pp. 121-136, 2013. 
  • Wang, R., Iwakura, Y., Araki, K., Keino-Masu, K., Masu, M., Wang, X., Takei, N., Higashiyama, S.and Nawa, H. ErbB2 Dephosphorylation and Anti-Proliferative Effects of Neuregulin-1 in ErbB2-Overexpressing Cell Lines; Potential Contribution of Their Low-Affinity Interaction. Scientific reports 3, 1402, 2013.
  • 桝和子、桝正幸.  ヘパラン硫酸微細構造の組織特異性とその決定機構. 医学のあゆみ. 245 (7), 600-602, 2013.

2012年

  • Nagamine, S., Tamba, M., Ishimine, H., Araki, K., Shiomi, K., Okada, T., Ohto, T., Kunita, S., Takahashi, S., Wismans, R.G.P., van Kuppevelt, T.H., Masu, M., and Kazuko Keino-Masu. Organ-Specific Sulfation Patterns of Heparan Sulfate Generated by Extracellular Sulfatases Sulf1 and Sulf2 in Mice. J Biol Chem 287, 9579-9590, 2012.
  • Nikitopoulou, I., Oikonomou, N., Karouzakis, E., Sevastou, I., Nikolaidou-Katsaridou, N., Zhao, Z., Mersinias, V., Armaka, M., Xu, Y., Masu, M., Mills, G. B., Gay, S., Kollias, G., and Aidinis, V. Autotaxin expression from synovial fibroblasts is essential for the pathogenesis of modeled arthritis. J Exp Med 209, 925-933, 2012.

2011年

  • Kamijo, H., Matsumura, Y., Thumkeo, D., Koike, S., Masu, M., Shimizu, Y., Ishizaki, T. and Narumiya, S. Impaired vascular remodeling in the yolk sac of embryos deficient in ROCK-I and ROCK-II. Genes Cells, 16, 1012-1021, 2011.
  • Koike, S., Yutoh, Y., Keino-Masu, K., Noji, S., Masu, M., and Ohuchi, H. Autotaxin is required for the cranial neural tube closure and establishment of the midbrain-hindbrain boundary during mouse development. Dev Dyn 240, 413-421, 2011.
  • Terawaki, S., Yano, K., Katsutani, T., Shiomi, K., Keino-Masu, K., Masu, M., Shomura, Y., Komori, H., Shibata, N., and Higuchi, Y. Crystallographic characterization of the DIX domain of the Wnt signalling positive regulator Ccd1. Acta Crystallographica F 67, 758-761, 2011.

2010年

  • Koike, S, Keino-Masu, K., and Masu, M. Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway. Biochem Biophys Res Commun 400, 66-71, 2010.
  • Yamazoe, H., Keino-Masu, K., and Masu, M. Combining the Cell Encapsulation Technique and Axon Guidance for Cell Transplantation Therapy. J Biomaterial Sci 21, 1815-1826, 2010.
  • Nagamine, S., Keino-Masu, K., Shiomi, K., and Masu, M. Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases. Biochem Biophys Res Commun 391, 107-112, 2010.

2009年

  • Koike, S., Keino-Masu, K., Ohto, T., Sugiyama, F., Takahashi, S., and Masu, M. Autotaxin/lysophospholipase D-mediated LPA Signaling is Required to Form Distinctive Large Lysosomes in the Visceral Endoderm Cells of the Mouse Yolk Sac. J Biol Chem 284, 33561-33570, 2009.
  • Hatanaka, Y., Matsumoto, T., Yanagawa, Y., Fujisawa, H., Murakami, F., Masu, M. Distinct Roles of Neuropilin 1 Signaling for Radial and Tangential Extension of Callosal Axons. J Comp Neurol 514, 215-225, 2009.
  • Ikeuchi, Y., Stegmuler, J., Netherton, S., Anh Huynh, M., Masu, M., Frank, D., Bonni, S., Bonni, A. A SnoN-Ccd1 Pathway Promotes Axonal Morphogenesis in the Mammalian Brain. J Neurosci 29, 4312-4321, 2009.

2008年

  • Keino-Masu, K., Masu, M. Heparan sulfate endosulfatase assay. Experimental Glycoscience (ed. by N. Taniguchi et al.), Springer-Verlag, pp. 123-124, 2008. 桝正幸. ヘパラン硫酸糖鎖による神経ネットワーク形成制御. 蛋白質核酸酵素. 53, 489-494, 2008.

2007年

  • Okada T, Keino-Masu K, Masu M. Migration and nucleogenesis of mouse precerebellar neurons visualized by in utero electroporation of a green fluorescent protein gene. Neurosci Res 57, 40-49, 2007.
  • Masu M, Keino-Masu K. Role of heparan sulfate 6-O-endosulfatases in the nervous system. In: Neural Proteoglycans (ed. by Maeda, N), Kerala, India, Research Signpost, pp. 103-114, 2007.

2006年

  • Kamimura K, Koyama T, Habuchi H, Ueda R, Masu M, Kimata K, Nakato H. Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. J Cell Biol 174, 773-778, 2006.
  • Takayanagi S, Hiroyama T, Yamazaki S, Nakajima T, Morita Y, Usui J, Eto K, Motohashi T, Shiomi K, Keino-Masu K, Masu M, Oike Y, Mori S, Yoshida N, Iwama A, Nakauchi H. Genetic marking of hematopoietic stem and endothelial cells: Identification of the Tmtsp genes encoding a novel cell-surface protein with the thrombospondin-1 domain. Blood 107, 4317-4325, 2006.
  • Soma K, Shiomi K, Keino-Masu K, Masu M. Expression of mouse Coiled-coil-DIX1 (Ccd1), a positive regulator of Wnt signaling, during embryonic development. Gene Expression Patterns 6, 325-330, 2006.
  • Koike S, Keino-Masu K, Ohto T, Masu M. The N-terminal hydrophobic sequence of autotaxin (ENPP2) functions as a signal peptide. Genes Cells 11, 135-143, 2006.

2005年

  • Nagamine S, Koike S, Keino-Masu K, Masu M. Expression of a heparan sulfate remodeling enzyme, heparan sulfate 6-O-endosulfatase sulfatase FP2, in the rat nervous system. Dev Brain Res 159, 135-143, 2005.
  • Shiomi K, Kanemoto M, Keino-Masu K, Yoshida S, Soma K, Masu M. Identification and differential expression of multiple isoforms of mouse Ccd1 (Coiled-coil-DIX1), a positive regulator of Wnt signaling. Mol Brain Res 135, 169-180, 2005.
  • 桝正幸. 神経回路形成におけるヘパラン硫酸の役割. 神経研究の進歩 49 (1): 95-103, 2005.
  • 桝正幸. 発生から見た神経回路のでき方. 朝日選書「脳はどこまでわかったか」(井原康夫編) pp. 257-284.

2004年

  • Sumazaki R, Shiojiri N, Isoyama S, Masu M, Keino-Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A. Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nature Genet 36, 83-7, 2004.
  • 桝正幸、桝和子. 新規のヘパラン硫酸エンドスルファターゼによる細胞間シグナルの調節. 蛋白質核酸酵素 49 (15), 2376-2383.

2003年

  • Shiomi K, Uchida H, Keino-Masu K, Masu M. Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. Curr Biol 13, 73-77, 2003.

2002年

  • Ohto T, Uchida H, Yamazaki H, Keino-Masu K, Matsui A, Masu M. Identification of a novel non-lysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage. Genes Cells 7, 173-186, 2002.
  • Tsukada S, Keino-Masu K, Masu M, Fukuda J. Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. Neurosci Lett 318, 17-20, 2002.
  • Sato H, Tamba M, Okuno S, Sato K, Keino-Masu K, Masu M, Bannai S. Distribution of cystine/glutamate exchange transporter, system xc-, in the mouse brain. J Neurosci 22, 8028-8033, 2002.

2001年

  • Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98, 6951-6956, 2001.

2000年以前の代表的論文

  • Leonardo ED, Hinck L, Masu M, Keino-Masu K, Ackerman SL, Tessier-Lavigne M. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838, 1997.
  • Fazeli A, Dickinson SL, Hermiston ML, Tighe RV, Steen RG, Small CG, Stoeckli ET, Keino-Masu K, Masu M, Rayburn H, Simons J, Bronson RT, Gordon JI, Tessier-Lavigne M, Weinberg RA. Phenotype of mice lacking functional Deleted in Colorectal Cancer (Dcc) gene. Nature 386, 796-804, 1997.
  • Keino-Masu K, Masu M, Hinck L, Leonardo ED, Chan SS-Y, Culotti J, Tessier-Lavigne M. Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor. Cell 87, 175-185, 1996.
  • Masu M, Iwakabe H, Tagawa Y, Miyoshi T, Yamashita M, Fukuda Y, Sasaki H, Hiroi K, Nakamura Y, Shigemoto R, Takada M, Nakamura K, Nakao K, Katsuki M, Nakanishi S. Specific Deficit of the ON Response in Visual Transmission by Targeted Disruption of the mGluR6 Gene. Cell 80, 757-765, 1995.
  • Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A Family of Metabotropic Glutamate Receptors. Neuron 8, 169-179, 1992.
  • Moriyoshi K, Masu M, Ishii T, Shigemoto R, Mizuno N, Nakanishi S. Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37, 1991.
  • Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. Sequence and expression of a metabotropic glutamate receptor. Nature 349, 760-765, 1991.