2017年

TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism.
Shen LT, Chou HE. and Kato M.
Biochem. Biophys. Res. Commun.2017 Oct 21;492(3):310-315. doi: 10.1016/j.bbrc.2017.08.117. Epub 2017 Aug 31.

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.
Okita Y, Kimura M, Rudy X, Chen C, Shen LTW, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH and Kato M.
Sci. Signal. 2017 Apr 11; 10(474). doi: 10.1126/scisignal.aak9397.

Targeting TGF-β Signaling in Cancer.
Colak S, Ten Dijke P.
Trends in cancer. 2017 Jan; 3(1): 56-71. doi: 10.1016/j.trecan.2016.11.008.

Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M, Mamura M.
Biochem. Biophys. Res. Commun. 2017 Mar 4; 484(2): 269-277. doi: 10.1016/j.bbrc.2017.01.093.

2016年

A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.
Leenheer D, Ten Dijke P, Hipolito CJ.
Biopolymers. 2016 Nov; 106(6): 889-900. doi: 10.1002/bip.22900.

In Vitro Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins.
Hipolito CJ, Nishio K, Suga H.
Yakugaku Zasshi. 2016; 136(2): 191-6. doi: 10.1248/yakushi.15-00229-4.

Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.
Lin J, Kato M, Nagata K, Okuwaki M.
Nucleic Acids Res. 2016 Dec 20. doi: 10.1093/nar/gkw1285. [Epub ahead of print] PMID: 28003476.

Regulation of bone morphogenetic protein signaling by ADP-ribosylation.
Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A.
J. Biol Chem. 2016 Apr 21. pii: jbc.M116.729699. [Epub ahead of print] PMID: 27129221.

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A.
Oncotarget. 7(2): 1120-1143, 2016. doi: 10.18632/oncotarget.6683. PMID: 26701726.

Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, Bartholin L, Moustakas A.
Methods Mol. Biol. 1344: 147-181, 2016. doi: 10.1007/978-1-4939-2966-5_9. PMID: 26520123. (IF: 1.29)

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S.
PLoS One.11(2): e0150010, 2016. doi: 10.1371/journal.pone.0150010. eCollection 2016. 2016 Feb 22, PMID: 26901059.

Regulation of the TMEPAI Promoter by TCF7L2: the C-terminal Tail of TCF7L2 is Essential to Activate the TMEPAI Gene.
Nakano N, Kato M, Itoh S.
J. Biochem. 159: 27-30, 2016. doi:10.1093/jb/mvv117. Epub 2015 Nov 20. PMID: 26590303. (3.073)

2015年

Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.
Hongu, T., Funakoshi, Y., Fukuhara, S., Suzuki, T., Sakimoto, S., Takakura, N., Ema, M., Takahashi, S.,Itoh, S., Kato, M., Hasegawa, H., Mochizuki, N., Kanaho, Y.
Nat. Commun. 2015; 6: 7925. doi: 10.1038/ncomms8925.

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Yoon, JH., Sudo, K., Kuroda, M., Kato, M., Lee, IK., Han, JS., Nakae, S., Imamura, T., Kim, J., Ju, JH., Kim, DK., Matsuzaki, K., Weinstein, M., Matsumoto, I., Sumida, T. and Mamura, M.
Nat. Commun. 62015 Jul21;6: 7600. doi: 10.1038/ncomms8600.

Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling.
Azami, S., Vo Nguyen, TT., Watanabe, Y. and Kato, M.
Biochem. Biophys. Res Commun. 2015; 456(2): 580-585.

2014年

病理標本の3次元再構築によるがんの特性の研究.
加藤光保、永田毅.
日本機械学会2014年度年次大会講演論文集. 2014.

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling.
Dahl, M., Maturi, V., Lonn, P., Papoutsoglou, P., Zieba, A., Vanlandewijck, M., van der Heide, LP., Watanabe, Y., Soderberg, O., Hottiger, MO., Heldin, CH. and Moustakas, A.
PLoS One. 2014; 9(8): e103651. doi: 10.1371/journal.pone.0103651. eCollection 2014.

C18ORF1: A Novel Negative Re,ulator of TGF-β Signaling.
Nakano, N., Maeyama, K., Sakata, N., Itoh, F., Akatsu, R., Nakata, M., Katsu, Y., Ikeno, S., Togawa, Y.,Vo Nguyen, TT., Watanabe, Y., Kato, M. and Itoh, S.
J. Biol. Chem. 2014; 289(18): 12680-12692.

TMEPAI/PMEPA1 enhances Tumorigenic Activities in Lung Cancer Cells.
Vo Nguyen, TT., Watanabe, Y., Shiba, A., Noguchi, M., Itoh, S., and Kato, M.
Cancer Sci. 2014; 105(3): 334-341.

上皮間葉移行
加藤光保沖田結花里
病理と臨床. 2014; 32(10): 1163-1167.

TGF-βシグナル伝達による酸化ストレス制御機構
沖田結花里加藤光保
医学のあゆみ. 2014; 250(6, 7): 511-515.

2013年

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing Eomesodermin in cytotoxic T lymphocytes.
Yoon, JH., Jung, SM., Park, SH., Kato, M., Yamashita, T., Lee, IK., Sudo, K., Nakae, S., Han, JS., Kim, OH., Oh, BC., Sumida, T., Kuroda, M., Ju, JH., Jung, KC., Park, SH., Kim, DK., and Mamura, M.
EMBO Mol. Med. 2013; 5: 1720-1739.

連続切片病理画像における位置合わせと細胞カウント
永田毅、不破敦、加藤光保
みずほ情報総研技報. 2013; 5(1): 1-6.

Transforming Growth Factor-β Induces transcription factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene.
Okita, Y., Kamoshida, A., Suzuki, H., Itoh, K., Motohashi, H., Igarashi, K., Yamamoto, M., Ogami, T., Koinuma, D. and Kato, M.
J. Biol. Chem. 2013; 288(28): 20658-20667.

Screening quality for Ca2+-activated potassium channel in IonWorks Quattro is greatly improved by using BAPTA-AM and ionomycin.
Ido, K., Ohwada, T., Yasutomi, E., Yoshinaga, T., Arai, T., Kato, M. and Sawada, K.
J. Pharmacol. Toxicol. Methods. 2013; 67(1): 16-24.

2012年

Delayed cutaneous wound healing in Fam129b/Minerva-deficient mice.
Oishi, H., Itoh, S., Matsumoto, K., Ishitobi, H., Suzuki, R., Ema, M., Kojima, T., Uchida, K., Kato, M., Miyata, T. and Takahashi, S.
J. Biochem. 2012; 152(6): 549-555.

Smad2/Smad3 in endothelium is indispensable for vascular stability via S1PR1 and N-cadherin expressions.
Itoh, F., Itoh, S., Adachi, T., Ichikawa, K., Matsumura, Y., Takagi, T., Festing, M., Watanabe, T., Weinstein, M., Karlsson, S. and Kato, M.
Blood. 2012; 119(22): 5320-5328.

2011年

Interference of E2-2-mediated effect in endothelial cells by FAM96B through its limited expression of E2-2.
Yang, W., Itoh, F., Ohya, H., Kishimoto, F., Tanaka, A., Nakano, N., Itoh, S. and Kato, M.
Cancer Sci.2011; 102(10): 1808-1814.

Establishment of a novel monoclonal antibody SMab-1 specific for IDHI-R132S mutation.
Kaneko, MK., Tian, W., Takano, S., Suzuki, H., Sawa, Y., Hozumi, Y., Goto, K., Yamazaki, K., Kitanaka, C. and Kato, Y.
Biochem. Biophys. Res. Commun. 2011; 406(4): 608-613.

Overexpression of the Transcription Factor Yin-Yang-1 Suppresses Differentiation of HaCaT Cells in Three-Dimensional Cell Culture.
Taguchi, S., Kawachi, Y., Ishitsuka, Y., Fujisawa, Y ., Furuta, J., Nakamura, Y., Xu X., Ikebe, D., Kato, M. and Otsuka, F.
J. Invest. Dermatol. 2011; 131(1): 37-45.

病理診断に役立つ分子生物学 TGF-β 解説編, TGF-β 診断編
渡邊幸秀, 加藤光保
病理と臨床 臨時増刊号 2011; 29: 432-439.

2010年

Tissue- and Development-Dependent Expression of the Small GTPase Arf6 in Mice.
Akiyama, M., Zhou, M., Sugimoto, R., Hongu, T., Furuya, M., Funakoshi, Y., Kato, M., Hasegawa, H., and Kanaho, Y.
Dev. Dynam. 2010; 239(12): 3416-3435.

Requirement of TCF7L2 for TGF-β-dependent transcriptional activation of the TMEPAI gene.
Nakano, N., Itoh, S., Watanabe, Y., Maeyama, K., Itoh, F. and Kato, M.
J. Biol. chem. 2010; 285(49): 38023-38033.

TGF-β Signaling in Gingival Fibroblast-Epithelial Interaction.
Ohshima, M., Yamaguchi, Y., Matsumoto, N., Micke, P., Takenouchi, Y., Nishida, T., Kato, M., Komiyama, K., Abiko, Y., Ito, K., Otsuka, K. and Kappert, K.
J. Dent. Res. 2010; 89(11): 1315-1321.

Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis.
Tanaka, A., Itoh, F., Nishiyama, K., Takezawa, T., Kurihara, H., Itoh, S. and Kato, M.
Blood. 2010; 115(20): 4138-4147.

Trichostatin A-Induced TGF-β Type II Recepter Expression in Retinoblastoma Cell Lines.
Kashiwagi, Y., Horie, K., Kanno, C., Inomata, M., Imamura, T., Kato, M., Yamamoto, T. and Yamashita, H.
IOVS. 2010; 51(2); 679-685.

Protein kinase C-dependent upregulation of miR-203 induces the differentiation of human keratinocytes.
Sonkoly, E., Wei, T., Pavez, L., Suzuki, H., Kato, M., Torma, H., Stahle, M. and Pivarcsi, A.
J. Invest. Dermatol. 2010; 130(1): 124-134.

TMEPAI , a Transmembrane TGF-β-Inducible Protein, Sequesters Smad Proteins from Active Participation in TGF-β Signaling.
Watanabe, Y., Itoh, S., Goto, T., Ohnishi, E., Inamitsu, M., Itoh, F., Satoh, K., Wiercinska, E., Yang, W., Shi, L., Tanaka, A., Nakano, N., Mommaas, AM., Shibuya, H., ten Dijke, P. and Kato, M.
Mol. Cell. 2010; 37(1): 123-134.

2009年

Poor Vessel Formation in Embryos from Knock-in Mice Expressing ALK5 with L45 Loop Mutation Defective in Smad Activation.
Itoh, F., Itoh, S.,Carvalho, RLC., Adachi, T., Ema, M., Goumans, MJ., Larsson, J., Karlsson, S., Takahashi, S., Mummery, CL., ten Dijke, P. and Kato, M.
Lab. Invest. 2009; 89(7): 800-810.

TAL1/SCL relieves the E2-2-mediated repression of VEGFR2 promoter activity.
Tanaka, A., Itoh, F., Itoh, S. and Kato, M.
J. Biochem. 2009; 145(2): 129-135.

2008年

Roles of mono-ubiquitinated Smad4 in the formation of Smad transcriptional complexes.
Wang, B., Suzuki, H. and Kato, M.
Biochem. Biophys. Res. Commun. 2008; 376(2): 288-292.

Induction of podoplanin by transforming growth factor-beta in human fibrosarcoma.
Suzuki, H., Kato, Y., Kaneko, MK., Okita, Y., Narimatsu, H. and Kato, M.
FEBS Lett. 2008; 582(2): 341-345.

Ephrin-A1 promotes the malignant progression of intestinal tumors in Apc min/+ mice.
Shi, L., Itoh, F., Itoh, S., Takahashi, S., Yamamoto, M. and Kato, M.
Oncogene. 2008; 27(23): 3265-3273.

2007年

Nagative regulation of TGF-beta receptor/Smad signal transduction.
Itoh, S., and ten Dijke, P.
Curr. Opin. Cell Biol. 2007; 19(2): 176-184.

Suppression of MafA-dependent transcription by transforming growth factor-beta signaling.
Matsumura, H., Kudo, T., Harada, A., Esaki, R., Suzuki, H., Kato, M. and Takahashi, S.
Biochem. Biophys. Res. Commun.2007; 364(1): 151-156.

Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice.
Carvalho, RL., Itoh, F., Goumans, MJ., Lebrin, F., Kato, M., Takahashi, S., Ema, M., Itoh, S., van Rooijen, M., Bertolino, P., ten Dijke, P. and Mummery, CL.
J. Cell Sci. 2007; 120(Pt 24): 4269-4277.

Suppression of keratinocyte stratification by a dominant negative JunB mutant without blocking cell proliferation.
Ikebe, D., Wang, B., Suzuki, H. and Kato, M.
Genes Cells.2007; 12(2): 197-207.

TGF-βファミリーと疾患
伊東進加藤光保
細胞. 2007; 39(8): 322-326.

2006年

Methylation of Smad6 by Protein Arginine N-Methyltransferase 1.
Inamitsu, M., Itoh, S., Hellman, U., ten Dijke, P. and Kato, M.
FEBS lett. 2006; 580(28-29): 6603-6611.

ELAC2, A Putative Prostate Cancer Susceptibility Gene Product, Potentiates TGF-β/Smad-induced Growth Arrest of Prostate Cells.
Noda, D.,Itoh, S., Watanabe, Y., Inamitsu, M., Dennler, S., Itoh, F., Koike, S., Dnielpour, D., ten Dijke, P. and Kato, M.
Oncogene. 2006; 25(41): 5591-5600.

2005年

Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells.
Suzuki, H., Watabe, T., Kato, M., Miyazawa, K. and Miyazono, K.
Blood. 2005; 105(6): 2372-2379.

Cell type-specific regulation of the TGF-β-responsive alpha2(I) collagen gene by CpG methylation.
Yamane, K., Suzuki, H., Ihn, H., Kato, M., Yoshikawa, H. and Tamaki, K.
J. Cell Physiol.2005; 202(3): 822-830.

TGF-β
加藤光保
予防医学事典. 朝倉書店, 2005; 358-359.

2004年

A Role for Id in the Regulation of TGF-β-induced epithelial-mesenchymal transdifferentiation.
Kondo, M., Cubillo, E., Tobiume, K., Shirakihara, T., Fukuda, N., Suzuki, H., Shimizu, K., Takehara, K., Cano, A., Sitoh, M. and Miyazono, K.
Cell Death Differ.2004; 11(10): 1092-1101.

Upregulated CD44v9 expression inhibits the invasion of oral squamous cell carcinoma cells.
Sato, S., Miyauchi, M., Kato, M., Kitajima, S., Kitagawa, S., Hiraoka, M., Kudo, Y., Ogawa, I. and Takata, T.
Pathobiology. 2004; 71(4): 171-175.

c-Ski inhibits the TGF-β signaling pathway through stabilization of inactive Smad complexes on Smad-binding elements.
Suzuki, H., Yagi, K., Kondo, M., Kato, M., Miyazono, K. and Miyazawa, K.
Oncogene. 2004; 23(29): 5068-5076.

CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter.
Ionescu, AM, Drissi, H., Schwarz, EM., Kato, M., Puzas, JE., McCance, DJ., Rosier, RN., Zuscik, MJ. and O'Keefe, RJ.
J. Cell Physiol. 2004; 198(3): 428-440.

Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells.
Itoh, F., Itoh, S., Goumans, MJ., Valdimardottir, G., Iso, T., Dotto, GP., Hamamori, Y., Kedes, L., Kato, M. and ten Dijke, P.
EMBO J. 2004; 23(3): 541-551.

Transforming growth factor-β signaling is differentially inhibited by Smad2D450E and Smad3D407E.
Kondo, M., Suzuki, H., Takehara, K., Miyazono, K. and Kato, M.
Cancer Sci.2004; 95(1): 12-17.

細胞の増殖調節と癌化
横山和尚、池田正明、加藤光保
キーワードで理解する転写イラストマップ. 羊土社, 2004; 176-193.

IGFBP.
鈴木裕之加藤光保
サイトカイン・増殖因子用語ライブラリー. 羊土社, 2004

2003年

Receptor tyrosine kinases inhibit bone morphogenetic protein-Smad responsive promoter activity and differentiation of murine MC3T3-E1 osteoblast-like cells.
Nakayama, K., Tamura, Y., Suzawa, M., Harada, S., Fukumoto, S., Kato, M., Miyazono, K., Rodan, GA., Takeuchi, Y. and Fujita, T.
J. Bone Miner Res. 2003 May; 18(5): 827-835.

Activin receptor-like kinase(ALK)1 is an antagonisitic mediator of lateral TGF-β/ALK5 signaling.
Goumans, M., Valdimarsdottir, G., Itoh, S., Lebrin, F., Larsson, J., Mummery, C., Karlsson, S and ten Dijke, P.
Mol. Cell. 2003 Oct; 12(4): 817-828

Synthetic triterpenoids enhance transforming growth factor β/Smad signaling.
Suh, N., Robert, AB., Birkey, Reffey S., Miyazono, K., Itoh, S., ten Dijke, P., Heiss, EH., Place, AE., Risingsong, R., Williams, CR., Honda, T., Gribble, GW. and Sporn, MB.
Cancer Res. 2003 Mar 15; 63(6): 1371-1376

SARA and Hgs attenuate susceptibility to TGF-β1-mediated T cell suppression.
Kunzmann, S., Wohlfahrt, JG., Itoh, S., Asao, H., Komada, M., Akdis, CA., Blaser, K. and Schmidt-Weber, CB.
FASEB J.2003 Feb;17(2): 194-202

Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses.
Itoh, S., Thorikay, M., Kowanetz, M., Moustakas, A., Itoh, F., Heldin, CH. and ten Dijke, P.
J. Biol. Chem.2003 Feb; 278(6): 3751-3761

Lymphoid enhancer factor 1 makes cells resistant to transforming growth factor β-induced repression of c-myc.
Sasaki, T., Suzuki, H., Yagi, K., Furuhashi, M., Yao, R., Susa, S., Noda, T., Arai, Y., Miyazono, K. and Kato, M.
Cancer Res. 2003 Feb 15; 63(4): 801-806.

トランスフォーミング増殖因子 βによる転写制御(PDF)
加藤光保
蛋白質 核酸 酵素. 2003 Dec; 48(16): 2247-2253

2002年

Compound disruption of Smad2 accelerates malignant progression of intestinal tumors in Apc knockout mice.
Hamamoto, T., Beppu, H., Okada, H., Kawabata, M., Kitamura, T., Miyazono, K. and Kato, M.
Cancer Res. 2002 Oct 15; 62(20): 5955-5961.

c-myc is a downstream target of the Smad pathway.
Yagi, K., Furuhashi, M., Aoki, H., Goto, D., Kuwano, H., Sugamura, K., Miyazono, K. and Kato, M.
J. Biol. Chem. 2002 Jan 4; 277(1): 854-861.