Novel integrated multiomics analysis reveals a key role for integrin beta-like 1 in wound scarring.
Kim SE, Noda R, Liu YC, Nakajima Y, Kameoka S, Motooka D, Mizuno S, Takahashi S, Takaya K, Murase T, Ikematsu K, Tratsiakova K, Motoyama T, Nakashima M, Kishi K, Martin P, Seno S, Okuzaki D, Mori R. EMBO Rep. PMID: 39558136
4E-BP3 deficiency impairs dendritic cell activation and CD4+ T cell differentiation and attenuates α-myosin-specific T cell-mediated myocarditis in mice.
Li S, Tajiri K, Yuan Z, Murakata Y, Song Z, Mizuno S, Xu D, Murakoshi N. Basic Res Cardiol. PMID: 39516410
Legius Syndrome mutations in the Ras-regulator SPRED1 abolish its membrane localization and potentially cause neurodegeneration.
Hirata Y, Brems H, Van der Auweraer S, Ohyagi M, Iizuka M, Mise-Omata S, Ito M, Messiaen L, Mizuno S, Takahashi S, Legius E, Yoshimura A. J Biol Chem. PMID: 39510187
Proximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins.
Yoshioka K, Nakagawa R, Nguyen CLK, Suzuki H, Ishigaki K, Mizuno S, Okiyoneda T, Ebihara S, Murata K. FEBS Open Bio. PMID: 39482856
PCPE-1, a brown adipose tissue-derived cytokine, promotes obesity-induced liver fibrosis.
Hsiao YT, Yoshida Y, Okuda S, Abe M, Mizuno S, Takahashi S, Nakagami H, Morishita R, Kamimura K, Terai S, Aung TM, Li J, Furihata T, Tang JY, Walsh K, Ishigami A, Minamino T, Shimizu I. EMBO J. PMID: 39160276
Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7.
Katoh M, Nomura S, Yamada S, Ito M, Hayashi H, Katagiri M, Heryed T, Fujiwara T, Takeda N, Nishida M, Sugaya M, Kato M, Osawa T, Abe H, Sakurai Y, Ko T, Fujita K, Zhang B, Hatsuse S, Yamada T, Inoue S, Dai Z, Kubota M, Sawami K, Ono M, Morita H, Kubota Y, Mizuno S, Takahashi S, Nakanishi M, Ushiku T, Nakagami H, Aburatani H, Komuro I. Circulation. PMID: 38991046
Dual-specificity phosphatases 13 and 27 as key switches in muscle stem cell transition from proliferation to differentiation.
Hayashi T, Sadaki S, Tsuji R, Okada R, Fuseya S, Kanai M, Nakamura A, Okamura Y, Muratani M, Wenchao G, Sugasawa T, Mizuno S, Warabi E, Kudo T, Takahashi S, Fujita R. Stem Cells. PMID: 38975693
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis.
Lee DJ, Kim P, Kim HY, Park J, Lee SJ, An H, Heo JS, Lee MJ, Ohshima H, Mizuno S, Takahashi S, Jung HS, Kim SJ. Exp Mol Med. PMID: 38945953
B Cells of Early-life Origin Defined by RAG2-based Lymphoid Cell Tracking under Native Hematopoietic Conditions.
Fujisaki K, Okazaki S, Ogawa S, Takeda M, Sugihara E, Imai K, Mizuno S, Takahashi S, Goitsuka R. J Immunol. PMID: 38874543
A rare olive compound oleacein functions as a TrkB agonist and mitigates neuroinflammation both in vitro and in vivo.
Wakasugi D, Kondo S, Ferdousi F, Mizuno S, Yada A, Tominaga K, Takahashi S, Isoda H. Cell Commun Signal. PMID: 38835076
Impaired glycosylation of gastric mucins drives gastric tumorigenesis and serves as a novel therapeutic target.
Arai J, Hayakawa Y, Tateno H, Murakami K, Hayashi T, Hata M, Matsushita Y, Kinoshita H, Abe S, Kurokawa K, Oya Y, Tsuboi M, Ihara S, Niikura R, Suzuki N, Iwata Y, Shiokawa T, Shiomi C, Uekura C, Yamamoto K, Fujiwara H, Kawamura S, Nakagawa H, Mizuno S, Kudo T, Takahashi S, Ushiku T, Hirata Y, Fujii C, Nakayama J, Shibata
S, Woods S, Worthley DL, Hatakeyama M, Wang TC, Fujishiro M. Gastroenterology. PMID: 38583723
Regional random mutagenesis driven by multiple sgRNAs and diverse on-target genome editing events to identify functionally important elements in non-coding regions. Morimoto K, Suzuki H, Kuno A, Daitoku Y, Tanimoto Y, Kato K, Murata K, Sugiyama F, Mizuno S. Open Biol. PMID: 38565160
Landscape of driver mutations and their clinical effects on Down syndrome-related myeloid neoplasms.
Sato T, Yoshida K, Toki T, Kanezaki R, Terui K, Saiki R, Ojima M, Ochi Y, Mizuno S, Yoshihara M, Uechi T, Kenmochi N, Tanaka S, Matsubayashi J, Kisai K, Kudo K, Yuzawa K, Takahashi Y, Tanaka T, Yamamoto Y, Kobayashi A, Kamio T, Sasaki S, Shiraishi Y, Chiba K, Tanaka H, Muramatsu H, Hama A, Hasegawa D, Sato A, Koh K, Karakawa S, Kobayashi M, Hara J, Taneyama Y, Imai C, Hasegawa D, Fujita N, Yoshitomi M, Iwamoto S, Yamato G, Saida S, Kiyokawa N, Deguchi T, Ito M, Matsuo H, Adachi S Prof, Hayashi Y, Taga T, Moriya Saito A, Horibe K, Watanabe K, Tomizawa D, Miyano S, Takahashi S, Ogawa S, Ito E. Blood. PMID: 38513239
Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation.
Kong X, Nguyen NV, Li Y, Sakr JS, Williams K, Sharifi S, Chau J, Bayrakci A, Mizuno S, Takahashi S, Kiyono T, Tawil R, Mortazavi A, Yokomori K. iScience. PMID: 38510139
MAX controls meiotic entry in sexually undifferentiated germ cells.
Suzuki A, Uranishi K, Nishimoto M, Mizuno Y, Mizuno S, Takahashi S, Eisenman RN, Okuda A. Sci Rep. PMID: 38433229
SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination.
Ha J, Kim M, Park JS, Lee Y, Lee JY, Shin JC, Seo D, Park SS, You J, Jung SM, Kim HY, Mizuno S, Takahashi S, Kim SJ, Park SH. Cell Rep. PMID: 38341852
Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice. Mikami N, Nguyen CLK, Osawa Y, Kato K, Ishida M, Tanimoto Y, Morimoto K, Murata K, Kang W, Sugiyama F, Ema M, Takahasi S, Mizuno S. Exp Anim. PMID: 38325858
Role of inter-alpha-trypsin inhibitor heavy chain 4 and its citrullinated form in experimental arthritis murine models.
Iwai T, Ohyama A, Osada A, Nishiyama T, Shimizu M, Miki H, Asashima H, Kondo Y, Tsuboi H, Mizuno S, Takahashi S, Ishigami A, Matsumoto I. Clin Exp Immunol. PMID: 38190323
Establishment and visual analysis of CBA/J-Pde6bY347Y/Y347X and C3H/HeJ-Pde6bY347Y/Y347X mice.
Shindo M, Terao M, Takada S, Ichinose M, Matsuzaka E, Yokoi T, Azuma N, Mizuno S, Tsumura H. Exp Anim. PMID: 38171880
2023
Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
Park S, Heo JS, Mizuno S, Kim MW, An H, Hong E, Kang MG, Kim J, Yun R, Park H, Noh EH, Lee MJ, Yoon K, Kim P, Son M, Pang K, Lee J, Park J, Ooshima A, Kim TJ, Park JY, Yang KM, Myung SJ, Bae H, Lee KM, Letterio J, Park SH, Takahashi S, Kim SJ. Metabolism. PMID: 38016540
Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis.
Tamura R, Sabu Y, Mizuno T, Mizuno S, Nakano S, Suzuki M, Abukawa D, Kaji S, Azuma Y, Inui A, Okamoto T, Shimizu S, Fukuda A, Sakamoto S, Kasahara M, Takahashi S, Kusuhara H, Zen Y, Ando T, Hayashi H. Nat Commun. PMID: 37990006
Activity of estrogen receptor β expressing neurons in the medial amygdala regulates preference toward receptive females in male mice.
Takenawa S, Nagasawa Y, Go K, Cherasse Y, Mizuno S, Sano K, Ogawa S. Proc Natl Acad Sci U S A. PMID: 37819977
Development of two mouse strains conditionally expressing bright luciferases with distinct emission spectra as new tools for in vivo imaging.
Nakashiba T, Ogoh K, Iwano S, Sugiyama T, Mizuno-Iijima S, Nakashima K, Mizuno S, Sugiyama F, Yoshiki A, Miyawaki A, Abe K. Lab Anim. PMID: 37679611
Null mutation of exocyst complex component 3-like does not affect vascular development in mice.
Takashima S, Okamura E, Ichiyama Y, Nishi K, Shimizu A, Watanabe C, Muto M, Matsumoto S, Tsukiyama-Fujii S, Tsukiyama T, Ogita H, Nishi E, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Mizutani KI, Ema M. Exp Anim. PMID: 37661429
A universal method for generating knockout mice in multiple genetic backgrounds using zygote electroporation. Tamari T#, Ikeda Y#, Morimoto K#, Kobayashi K, Mizuno-Iijima S, Ayabe S, Kuno A, Mizuno S, Yoshiki A. Biol Open. PMID: 37623822
(#Contributed equally.)
Loss of CtBP2 may be a mechanistic link between metabolic derangements and progressive impairment of pancreatic β cell function.
Sekiya M, Ma Y, Kainoh K, Saito K, Yamazaki D, Tsuyuzaki T, Chen W, Adi Putri PIP, Ohno H, Miyamoto T, Takeuchi Y, Murayama Y, Sugano Y, Osaki Y, Iwasaki H, Yahagi N, Suzuki H, Motomura K, Matsuzaka T, Murata K, Mizuno S, Takahashi S, Shimano H. Cell Rep. PMID: 37557182
Generation of a MyoD knock-in reporter mouse line to study muscle stem cell dynamics and heterogeneity.
Fujita R, Mizuno S, Sadahiro T, Hayashi T, Sugasawa T, Sugiyama F, Ono Y, Takahashi S, Ieda M. iScience. PMID: 37250337
Generation and mutational analysis of a transgenic murine model of the human MAF mutation.
Fujino M, Ojima M, Ishibashi S, Mizuno S, Takahashi S. Am J Med Genet A. PMID: 37186330
Structure and Function of Neuronal Circuits linking Ventrolateral Preoptic Nucleus and Lateral Hypothalamic Area.
Prokofeva K, Saito YC, Niwa Y, Mizuno S, Takahashi S, Hirano A, Sakurai T. J Neurosci. PMID: 37117013
Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH, and diet restriction in mice.
Tsuji S, Brace CS, Yao R, Tanie Y, Tada H, Rensing N, Mizuno S, Almunia J, Kong Y, Nakamura K, Furukawa T, Ogiso N, Toyokuni S, Takahashi S, Wong M, Imai SI, Satoh A. Life Sci Alliance. PMID: 37045472
Cholesterol sulfate limits neutrophil recruitment and gut inflammation during mucosal injury.
Morino K, Kunimura K, Sugiura Y, Izumi Y, Matsubara K, Akiyoshi S, Maeda R, Hirotani K, Sakata D, Mizuno S, Takahashi S, Bamba T, Uruno T, Fukui Y. Front Immunol. PMID: 37006281
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis.
Sanada Y, Ikuta Y, Ding C, Yimiti D, Kato Y, Nakasa T, Mizuno S, Takahashi S, Huang W, Lotz MK, Adachi N, Miyaki S. Mech Ageing Dev. PMID: 37003368
SIK3-HDAC4 in the suprachiasmatic nucleus regulates the timing of arousal at the dark onset and circadian period in mice.
Asano F, Kim SJ, Fujiyama T, Miyoshi C, Hotta-Hirashima N, Asama N, Iwasaki K, Kakizaki M, Mizuno S, Mieda M, Sugiyama F, Takahashi S, Shi S, Hirano A, Funato H, Yanagisawa M. Proc Natl Acad Sci USA. PMID: 36877841
2022
Kinase signalling in excitatory neurons regulates sleep quantity and depth.
Kim SJ, Hotta-Hirashima N, Asano F, Kitazono T, Iwasaki K, Nakata S, Komiya H, Asama N, Matsuoka T, Fujiyama T, Ikkyu A, Kakizaki M, Kanno S, Choi J, Kumar D, Tsukamoto T, Elhosainy A, Mizuno S, Miyazaki S, Tsuneoka Y, Sugiyama F, Takahashi S, Hayashi Y, Muratani M, Liu Q, Miyoshi C, Yanagisawa M, Funato H. Nature. PMID: 36477539
Share Regulation of neural stem cell proliferation and survival by protein arginine methyltransferase 1.
Hashimoto M, Takeichi K, Murata K, Kozakai A, Yagi A, Ishikawa K, Suzuki-Nakagawa C, Kasuya Y, Fukamizu A, Nakagawa T. Front Neurosci. PMID: 36440275
Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice.
Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S, Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani KI, Ema M. Life. PMID: 36362885
Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
Maruta T, Hidaka K, Kouroki S, Koshida T, Kurogi M, Kage Y, Mizuno S, Shirasaka T, Yanagita T, Takahashi S, Takeya R, Tsuneyoshi I. PLoS One. PMID: 36201719
Alternative splicing for germ cell-specific Mga transcript can be eliminated without compromising mouse viability or fertility.
Kitamura Y, Suzuki A, Uranishi K, Nishimoto M, Mizuno S, Takahashi S, Okuda A. Dev Growth Differ. PMID: 36053973
Clonal germinal center B cells function as a niche for T-cell lymphoma.
Fujisawa M, Nguyen TB, Abe Y, Suehara Y, Fukumoto K, Suma S, Makishima K, Kaneko C, Nguyen YTM, Usuki K, Narita K, Matsue K, Nakamura N, Ishikawa S, Miura F, Ito T, Suzuki A, Suzuki Y, Mizuno S, Takahashi S, Chiba S, Sakata-Yanagimoto M. Blood. PMID: 35921527
Zygote Microinjection for Creating Gene Cassette Knock-in and Flox Alleles in Mice.
Tanimoto Y#, Mikami N#, Ishida M, Iki N, Kato K, Sugiyama F, Takahashi S, Mizuno S.
(#Contributed equally.) J Vis Exp. PMID: 35815994
Mast4 determines the cell fate of MSCs for bone and cartilage development.
Kim P, Park J, Lee DJ, Mizuno S, Shinohara M, Hong CP, Jeong Y, Yun R, Park H, Park S, Yang KM, Lee MJ, Jang SP, Kim HY, Lee SJ, Song SU, Park KS, Tanaka M, Ohshima H, Cho JW, Sugiyama F, Takahashi S, Jung HS, Kim SJ. Nat Commun. PMID: 35803931
The role of programmed cell death ligand-1 on Langerhans cells in the regulation of psoriasis.
Tanaka R, Ichimura Y, Kubota N, Konishi R, Nakamura Y, Mizuno S, Takahashi S, Fujimoto M, Nomura T, Okiyama N. J Invest Dermatol. PMID: 35803322
Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.
Ojima K, Kakegawa W, Yamasaki T, Miura Y, Itoh M, Michibata Y, Kubota R, Doura T, Miura E, Nonaka H, Mizuno S, Takahashi S, Yuzaki M, Hamachi I, Kiyonaka S. Nat Commun. PMID: 35710788
Birth of mice from meiotically arrested spermatocytes following biparental meiosis in halved oocytes.
Ogonuki N, Kyogoku H, Hino T, Osawa Y, Fujiwara Y, Inoue K, Kunieda T, Mizuno S, Tateno H, Sugiyama F, Kitajima TS, Ogura A. EMBO Rep. PMID: 35587095
Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells.
Tsukimoto S, Hakata Y, Tsuji-Kawahara S, Enya T, Tsukamoto T, Mizuno S, Takahashi S, Nakao S, Miyazawa M. Viruses. PMID: 35458563
Generation of a Gal4-dependent gene recombination and illuminating mouse.
Yoshihara M, Nishino T, Sambe N, Nayakama T, Radtke F, Mizuno S, Takahashi S. Exp Anim. PMID: 35444103
L17ER4: A cell-permeable attenuated cationic amphiphilic lytic peptide.
Shinga K, Iwata T, Murata K, Daitoku Y, Michibata J, Arafiles JVV, Sakamoto K, Akishiba M, Takatani-Nakase T, Mizuno S, Sugiyama F, Imanishi M, Futaki S. Bioorg Med Chem. PMID: 35395514
Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage.
Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K. Int J Mol Sci. PMID: 35328622
Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
Horie T, Fukasawa K, Yamada T, Mizuno S, Iezaki T, Tokumura K, Iwahashi S, Sakai S, Suzuki A, Kubo T, Osumi R, Tomizawa A, Ochi H, Sato S, Kaneda K, Takahashi S, Hinoi E. Stem Cells. PMID: 35304894
Thrombin cleavage of osteopontin initiates osteopontin's tumor-promoting activity.
Peraramelli S, Zhou Q, Zhou Q, Wanko B, Zhao L, Nishimura T, Leung TH, Mizuno S, Ito M, Myles T, Stulnig TM, Morser J, Leung LLK. J Thromb Haemost. PMID: 35108449
DAJIN enables multiplex genotyping to simultaneously validate intended and unintended target genome editing outcomes.
Kuno A#, Ikeda Y#, Ayabe S#, Kato K, Sakamoto K, Suzuki SR, Morimoto K, Wakimoto A, Mikami N, Ishida M, Iki N, Hamada Y, Takemura M, Daitoku Y, Tanimoto Y, Dinh TTH, Murata K, Hamada M, Muratani M, Yoshiki A, Sugiyama F, Takahashi S, Mizuno S.
(#Contributed equally.) PLoS Biol. PMID: 35041655
2021
Albino mice with the point mutation at the tyrosinase locus show high cholesterol diet-induced NASH susceptibility
Kulathunga K, Wakimoto A, Hiraishi Y, Yadav MK, Gentleman K, Warabi E, Sakasai T, Miwa Y, Mizuno S, Takahashi S, Hamada M. Sci Rep. PMID: 34750345
A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis
Nakagawa T, Jorg JD, Watanabe H, Mizuno S, Han S, Ikeda T, Omatsu Y, Nishimura K, Fujita M, Takahashi S, Kondoh G, Simons DB, Yoshida S, Nagasawa T Cell Rep. PMID: 34686326
Differential involvement of programmed cell death ligands in skin immune responses
Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Mizuno S, Takahashi S, Fujimoto M, Okiyama N. J Invest Dermatol. PMID: 34310947
Generation and characterisation of a cell-type specific, inducible Cre-driver line to study olfactory processing.
Koldaeva A, Zhang C, Huang YP, Reinert JK, Mizuno S, Sugiyama F, Takahashi S, Soliman T, Matsunami H, Fukunaga I. J Neurosci. PMID: 34099512
Starvation-induced transcription factor CREBH negatively governs body growth by controlling GH signaling.
Nakagawa Y, Kumagai K, Han SI, Mizunoe Y, Araki M, Mizuno S, Ohno H, Matsuo K, Yamada Y, Kim JD, Miyamoto T, Sekiya M, Konishi M, Itoh N, Matsuzaka T, Takahashi S, Sone H, Shimano H. FASEB J. PMID: 34042217
Efficient induction of proximity-dependent labeling by biotin feeding in BMAL1-BioID knock-in mice. Murata K, Mimura A, Suzuki H, Mikami N, Hamada Y, Kato K, Iki N, Ishida M, Daitoku Y, Tanimoto Y, Okiyoneda T, Fujiyama T, Dinh TTH, Mizuno S, Sugiyama F. J Biochem. PMID: 33982090
EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice. Osawa Y#, Murata K#, Usui M, Kuba Y, Le HT, Mikami N, Nakagawa T, Daitoku Y, Kato K, Shawki HH, Ikeda Y, Kuno A, Morimoto K, Tanimoto Y, Dinh TTH, Yagami KI, Ema M, Yoshida S, Takahashi S, Mizuno S, Sugiyama F.(#Contributed equally.) Elife. PMID: 33973520
Disruption of entire Cables2 locus leads to embryonic lethality by diminished Rps21 gene expression and enhanced p53 pathway. Dinh TTH#, Iseki H#, Mizuno S#, Iijima-Mizuno S, Tanimoto Y, Daitoku Y, Kato K, Hamada Y, Hasan ASH, Suzuki H, Murata K, Muratani M, Ema M, Kim JD, Ishida J, Fukamizu A, Kato M, Takahashi S, Yagami KI, Wilson V, Arkell RM, Sugiyama
F.(#Contributed equally.) Elife. PMID: 33949947
Induction of mutant Sik3Sleepy allele in neurons in late infancy increases sleep need.
Iwasaki K, Fujiyama T, Nakata S, Park M, Mioshi C, Hotta-Hirashima N, Ikkyu A, Kakizaki M, Sugiyama F, Mizuno S, Abe M, Sakimura K, Takahashi S, Funato H, Yanagisawa M. J Neurosci. PMID: 33558433
FGF23 from erythroblasts promotes hematopoietic progenitor mobilization.
Ishii S, Suzuki T, Wakahashi K, Asada N, Kawano Y, Kawano H, Sada A, Minagawa K, Nakamura Y, Mizuno S, Takahashi S, Matsui T, Katayama Y. Blood. PMID: 33512467
2020
Mast4 knockout shows the regulation of spermatogonial stem cell self-renewal via the FGF2/ERM pathway.
Lee SJ, Park J, Lee DJ, Otsu K, Kim P, Mizuno S, Lee MJ, Kim HY, Harada H, Takahashi S, Kim SJ, Jung HS. Cell Death Differ. 2020 Nov 20. doi: 10.1038/s41418-020-00670-2.
Transcriptomic Evaluation of Pulmonary Fibrosis-Related Genes: Utilization of Transgenic Mice with Modifying p38 Signal in the Lungs.
Matsuda S, Kim JD, Sugiyama F, Matsuo Y, Ishida J, Murata K, Nakamura K, Namiki K, Sudo T, Kuwaki T, Hatano M, Tatsumi K, Fukamizu A, Kasuya Y. Int J Mol Sci. 2020 Sep 14;21(18):6746. doi: 10.3390/ijms21186746.
Activation of CD8 T cells accelerates anti-PD-1 antibody-induced psoriasis-like dermatitis through IL-6.
Tanaka R, Ichimura Y, Kubota N, Saito A, Nakamura Y, Ishitsuka Y, Watanabe R, Fujisawa Y, Kanzaki M, Mizuno S, Takahashi S, Fujimoto M, Okiyama N. Commun Biol. 2020 Oct 15;3(1):571. doi: 10.1038/s42003-020-01308-2.
Loss of PRMT1 in the central nervous system (CNS) induces reactive astrocytes and microglia during postnatal brain development
Hashimoto M, Kumabe A, Kim JD, Murata K, Sekizar S, Williams A, Lu W, Ishida J, Nakagawa T, Endo M, Minami Y, Fukamizu A. J. Neurochem First published: 16 August 2020 https://doi.org/10.1111/jnc.15149
Sleep Architecture in Mice Is Shaped by the Transcription Factor AP-2β.
Nakai A, Fujiyama T, Nagata N, Kashiwagi M, Ikkyu A, Takagi M, Tatsuzawa C, Tanaka K, Kakizaki M, Kanuka M, Kawano T, Mizuno S, Sugiyama F, Takahashi S, Funato H, Sakurai T, Yanagisawa M, Hayashi Y. Genetics. 2020 Sep 2:genetics.303435.2020. doi: 10.1534/genetics.120.303435. Online ahead of print. PMID: 32878901
Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo. Hasan ASH, Dinh TTH, LE HT, Mizuno-Iijima S, Daitoku Y, Ishida M, Tanimoto Y, Kato K, Yoshiki A, Murata K, Mizuno S, Sugiyama F. Exp Anim. 2020 Aug 11. doi: 10.1538/expanim.20-0063. Online ahead of print. PMID: 32779618
Ablation of Ventral Midbrain/Pons GABA Neurons Induces Mania-like Behaviors with Altered Sleep Homeostasis and Dopamine D2R-mediated Sleep Reduction.
Honda T, Takata Y, Cherasse Y, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M, Lazarus M, Oishi Y. iScience. 2020 Jun 4;23(6):101240. doi: 10.1016/j.isci.2020.101240. PMID: 3256315
Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules.
Sakamoto K, Akishiba M, Iwata T, Murata K, Mizuno S, Kawano K, Imanishi M, Sugiyama F, Futaki S. Angew Chem Int Ed Engl. 2020 Jun 18. doi: 10.1002/anie.202005887. PMID: 32557993
Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis. Morimoto K, Numata K, Daitoku Y, Hamada Y, Kobayashi K, Kato K, Suzuki H, Ayabe S, Yoshiki A, Takahashi S, Murata K, Mizuno S, Sugiyama F. Sci Rep. 2020 June 3;10:9060. https://doi.org/10.1038/s41598-020-65986-y
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H. Sci Rep. 2020 May 26;10(1):8676. doi: 10.1038/s41598-020-65647-0.
Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes. Mizuno-Iijima S, Ayabe S, Kato K, Matoba S, Ikeda Y, Dinh TTH, Le HT, Suzuki
H, Nakashima K, Hasegawa Y, Hamada Y, Tanimoto Y, Daitoku Y, Iki N, Ishida
M, Elsayed Ibrahim Elzeftawy A, Nakashiba T, Hamada M, Murata K, Miwa Y,
Okada-Iwabu M, Iwabu M, Yagami KI, Ogura A, Obata Y, Takahashi S, Mizuno
S, Yoshiki A, Sugiyama F Methods. 2020 Apr 22. pii: S1046-2023(19)30328-7. doi: 10.1016/j.ymeth.2020.04.007.
Generation of B6-Ddx4em1(CreERT2)Utr, a Novel CreERT2 Knock-In Line, for Germ Cell Lineage by CRISPR/Cas9. Le HT, Hasegawa Y, Daitoku Y, Kato K, Miznuo-Iijima S, Dinh TTH, Kuba Y, Osawa Y, Mikami N, Morimoto K, Ayabe S, Tanimoto Y, Murata K, Yagami KI, Takahashi S, Mizuno S, Sugiyama F.
Genesis. 2020 Jul;58(7):e23367. doi: 10.1002/dvg.23367. Epub 2020 Apr 15.
PMID: 32293787.
c-Maf deletion in adult C57BL/6J mice induces cataract formation and abnormal differentiation of lens fiber cells.
Fujino M, Tagami A, Ojima M, Mizuno S, Abdellatif AM, Kuno A, Takahashi S Exp Anim. 2020 Jan 21. doi: 10.1538/expanim.19-0137
2019
Modulation of methotrexate-induced intestinal mucosal injury by dietary factors.
Higuchi T , Yoshimura M, Oka S, Tanaka K, Naito T, Yuhara S, Warabi E, Mizuno S, Ono M, Takahashi S, Tohma S, Tsuchiya N, Furukawa H Hum Exp Toxicol.2019 Dec 26 https://doi.org/10.1177/0960327119896605
RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.
Pang K, Park J, Ahn SG, Lee J, Park Y, Ooshima A, Mizuno S, Yamashita S, Park KS, Lee SY, Jeong J, Ushijima T, Yang KM, Kim SJ. Nat Commun2019 Dec 20;10(1):5805 doi:10.1038/s41467-019-13852-5
Highly efficient CRISPR-targeting of the murine Hipp11 intergenic region supports inducible human transgene expression.
Browning J, Rooney M, Hams E, Takahashi S, Mizuno S, Sugiyama F, Fallon PG, Kelly VP. Mol Biol Rep.2019 Dec 6. doi: 10.1007/s11033-019-05204-9.
Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model.
Chang YH, Katoh MC, Abdellatif AM, Xiafukaiti G, Elzeftawy A, Ojima M, Mizuno S, Kuno A, Takahashi S Exp Anim.2019 Dec 2. doi: 10.1538/expanim.19-0105.
Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720.
Fukuda A, Honda S, Fujioka N, Sekiguchi Y, Mizuno S, Miwa Y, Sugiyama F, Hayashi Y, Nishimura K, Hisatake K PLoS One. 2019 Nov 15;14(11):e0225213.
Regulations of bile acid metabolism in mouse models with hydrophobic bile acid composition.
Honda A, Miyazaki T, Iwamoto J, Hirayama T, Morishita Y, Monma T, Ueda
H, Mizuno S, Sugiyama F, Takahashi S, Ikegami T. J Lipid Res. 2019 Oct 23. pii: jlr.RA119000395.
Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation.
Gurumurthy CB, O'Brien AR, Quadros RM, Adams J Jr, Alcaide P, Ayabe S, Ballard J, Batra SK, Beauchamp MC, Becker KA, Bernas G, Brough D, Carrillo-Salinas F, Chan W, Chen H, Dawson R, DeMambro V, D'Hont J, Dibb KM, Eudy JD, Gan L, Gao J, Gonzales A, Guntur AR, Guo H, Harms DW, Harrington A, Hentges KE, Humphreys N, Imai S, Ishii H, Iwama M, Jonasch E, Karolak M, Keavney B, Khin NC, Konno M, Kotani Y, Kunihiro Y, Lakshmanan I, Larochelle C, Lawrence CB, Li L, Lindner V, Liu XD, Lopez-Castejon G, Loudon A, Lowe J, Jerome-Majewska LA, Matsusaka T, Miura H, Miyasaka Y, Morpurgo B, Motyl K, Nabeshima YI, Nakade K, Nakashiba T, Nakashima K, Obata Y, Ogiwara S, Ouellet M, Oxburgh L, Piltz S, Pinz I, Ponnusamy MP, Ray D, Redder RJ, Rosen CJ, Ross N, Ruhe MT, Ryzhova L, Salvador AM, Alam SS, Sedlacek R, Sharma K, Smith C, Staes K, Starrs L, Sugiyama F, Takahashi S, Tanaka T, Trafford AW, Uno Y, Vanhoutte L, Vanrockeghem F, Willis BJ, Wright CS, Yamauchi Y, Yi X, Yoshimi K, Zhang X, Zhang Y, Ohtsuka M, Das S, Garry DJ, Hochepied T, Thomas P, Parker-Thornburg J, Adamson AD, Yoshiki A, Schmouth JF, Golovko A, Thompson WR, Lloyd KCK, Wood JA, Cowan M, Mashimo T, Mizuno S, Zhu H, Kasparek P, Liaw L, Miano JM, Burgio G. Genome Biol. 2019 Aug 26;20(1):171. doi: 10.1186/s13059-019-1776-2
Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
Yasuda D, Kobayashi D, Akahoshi N, Ohto-Nakanishi T, Yoshioka K, Takuwa Y, Mizuno S, Takahashi S, Ishii S. J Clin Invest. 2019 Jul 23;130. pii: 121955.
Generation of bicistronic reporter knockin mice for visualizing germ layers. Suzuki H, Dinh TTH, Daitoku Y, Tanimoto Y, Kato K, Azami T, Ema M, Murata K, Mizuno S, Sugiyama F Exp Anim. 2019 Jun 13. doi: 10.1538/expanim.19-0031. [Epub ahead of print].
The chromatin binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A. Blood. 2019 Mar 27. pii: blood.2019000468. doi: 10.1182/blood.2019000468.
KOnezumi: a web application for automating gene disruption strategies to generate knockout mice.
Kuno A, Mizuno S, Takahashi S. Bioinformatics. 2019 Feb 6. doi: 10.1093/bioinformatics/btz090.
Generating Vegfr3 reporter transgenic mouse expressing membrane-tagged Venus for visualization of VEGFR3 expression in vascular and lymphatic endothelial cells.
Watanabe C, Matsushita J, Azami T, Tsukiyama-Fujii S, Tsukiyama T, Mizuno S, Takahashi S, Ema M. PLoS One. 2019 Jan 2;14(1):e0210060. doi: 10.1371/journal.pone.0210060. eCollection 2019.
2018
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
Kitadate Y, Jorg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C,
Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto
Y, Takahashi S, Simons BD, Yoshida S. Cell Stem Cell.2018 Dec 11. pii: S1934-5909(18)30549-6.
Mice harboring an MCTO mutation exhibit renal failure resembling nephropathy in human patients.
Tsunakawa Y, Hamada M, Matsunaga Y, Fuseya S, Jeon H, Wakimoto Y, Usui
T, Kanai M, Mizuno S, Morito N, Takahashi S. Exp Anim. 2018 Oct 26. doi: 10.1538/expanim.18-0093.
A single phosphorylation site of SIK3 regulates daily sleep amounts and
sleep need in mice.
Honda T, Fujiyama T, Miyoshi C, Ikkyu A, Hotta-Hirashima N, Kanno S, Mizuno S, Sugiyama F, Takahashi S, Funato H, Yanagisawa M Proc Natl Acad Sci U S A. 2018 Sep 25. pii: 201810823.
Anti-Fractalkine Antibody Suppresses Joint Destruction by Inhibiting Migration
of Osteoclast Precursors to the Synovium in Experimental Arthritis.
Hoshino-Negishi K, Ohkuro M, Nakatani T, Kuboi Y, Nishimura M, Ida Y, Kakuta
J, Hamaguchi A, Kumai M, Kamisako T, Sugiyama F, Ikeda W, Ishii N, Yasuda N, Imai T. Arthritis Rheumatol. 2018 Aug 6. doi: 10.1002/art.40688.
De Novo Mutations Activating Germline TP53 in an Inherited Bone-Marrow-Failure
Syndrome.
Toki T, Yoshida K, Wang R, Nakamura S, Maekawa T, Goi K, Katoh MC, Mizuno S, Sugiyama F, Kanezaki R, Uechi T, Nakajima Y, Sato Y, Okuno Y, Sato-Otsubo A, Shiozawa
Y, Kataoka K, Shiraishi Y, Sanada M, Chiba K1, Tanaka H, Terui K, Sato
T, Kamio T, Sakaguchi H, Ohga S, Kuramitsu M, Hamaguchi I, Ohara A, Kanno
H, Miyano S, Kojima S, Ishiguro A, Sugita K, Kenmochi N, Takahashi S, Eto
K, Ogawa S, Ito E. Am J Hum Genet. 2018. pii: S0002-9297(18)30247-7.
ZMYND10 functions in a chaperone relay during axonemal dynein assembly.
Mali GR, Yeyati PL, Mizuno S, Dodd DO, Tennant PA, Keighren MA, Zur Lage P, Shoemark A, Garcia-Munoz
A, Shimada A, Takeda H, Edlich F, Takahashi S, von Kreisheim A, Jarman
AP, Mill P. Elife. 2018 Jun 19;7. pii: e34389.
A mutation in transcription factor MAFB causes Focal Segmental Glomerulosclerosis
with Duane Retraction Syndrome.
Sato Y, Tsukaguchi H, Morita H, Higasa K, Tran MTN, Hamada M, Usui T, Morito
N, Horita S, Hayashi T, Takagi J, Yamaguchi I, Nguyen HT, Harada M, Inui
K, Maruta Y, Inoue Y, Koiwa F, Sato H, Matsuda F, Ayabe S, Mizuno S, Sugiyama F, Takahashi S, Yoshimura A. Kidney Int. 2018 May 17. pii: S0085-2538(18)30216-3.
Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored
Lymph Node Organogenesis.
Takahashi T, Katano I, Ito R, Goto M, Abe H, Mizuno S, Kawai K, Sugiyama F, Ito M. Front Immunol. 2018 Jan 17;8:2017.
2017
Simple generation of hairless mice for in vivo imaging. Hoshino Y, Mizuno S, Kato K, Mizuno-Iijima S, Tanimoto Y, Ishida M, Kajiwara N, Sakasai T, Miwa Y, Takahashi S, Yagami K, Sugiyama F. Exp Anim. 2017 Oct 30;66(4):437-445.
Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative
Stress.
Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A,
Sugiyama F, Takahashi S, Yamamoto M. Cell Rep. 2017 Feb 21;18(8):2030-2044. doi: 10.1016/j.celrep.2017.01.064.
SHISA6 Confers Resistance to Differentiation-Promoting Wnt/β-Catenin Signaling
in Mouse Spermatogenic Stem Cells.
Tokue M, Ikami K, Mizuno S, Takagi C, Miyagi A, Takada R, Noda C, Kitadate Y, Hara K, Mizuguchi H,
Sato T, Taketo MM, Sugiyama F, Ogawa T, Kobayashi S, Ueno N, Takahashi S, Takada S, Yoshida S. Stem Cell Reports. 2017 Mar 14;8(3):561-575..
Angiodysplasia in embryo lacking protein arginine methyltransferase 1 (PRMT1)
in vascular endothelial cells.
Ishimaru T, Ishida J, Kim JD, Mizukami H, Hara K, Hashimoto M, Yagami KI, Sugiyama F, Fukamizu A J Biochem. 2017 Mar 1;161(3):255-258.
2016
Forward-genetics analysis of sleep in randomly mutagenized mice
Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane
S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H,
Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M,
Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi
JS, Yanagisawa M Nature. 2016 Nov 17;539(7629):378-383. doi: 10.1038/nature20142.
Bio-active polymer implants to adipose tissue as in situ source of reprogramming
cells.
Mikhailov A, Sugiyama F, Mizuno-Iijima S, Sankai Y. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:4169-4172. doi: 10.1109/EMBC.2016.7591645.
Generation of CRISPR/Cas9-mediated bicistronic knock-in Ins1-cre driver
mice Hasegawa Y, Hoshino Y, Abdelaziz E. Ibrahim, Kato K, Daitoku Y, Tanimoto Y, Ikeda Y, Oishi H, Takahashi S, Yoshiki A, Yagami K, Iseki H, Mizuno S, Sugiyama F Exp Anim. 2016 Jul 29;65(3):319-27. doi: 10.1538/expanim.16-0016.
Germline recombination in a novel Cre transgenic line, Prl3b1-cre mouse.
Al-Soudy AS, Nakanishi T, Mizuno S, Hasegawa Y, Shawki HH, Katoh MC, Basha WA, Ibrahim AE, El-Shemy HA, Iseki H, Yoshiki A, Hiromori Y, Nagase H, Takahashi S, Oishi H, Sugiyama F. Genesis. 2016 Jul;54(7):389-97. doi: 10.1002/dvg.22944.
Hyperlipidemia and hepatitis in liver-specific CREB3L3 knockout mice generated
using a one-step CRISPR/Cas9 system
Nakagawa Y, Oikawa F, Mizuno S, Ohno H, Yagishita Y, Satoh A, Osaki Y, Takei K, Kikuchi T, S.I. Han,
Matsuzaka T, Iwasaki H, Kobayashi K, Yatoh S, Yahagi N, Suzuki H, Sone
H, Takahashi S, Yamada N, Shimano H Sci Rep. 2016 Jun 13;6:27857. doi: 10.1038/srep27857.
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers.
Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda
T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato
T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata, W, Nakamura
H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase
K, Izutsu K, Takaori-Kondo A, Miyazak Y, Takahashi S, Shibata T, Kawamoto
H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S Nature. 2016 May 23;534(7607):402-6. doi: 10.1038/nature18294.
H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto
H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki
Y, Nagai T, Okano H, Yagami KI, Tanaka M, Fukuda K. Stem Cell Reports. 2016 May 20. pii: S2213-6711(16)30040-6.
Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic
studies.
Shimbo M1, Kudo T, Hamada M, Jeon H, Imamura Y, Asano K, Okada R, Tsunakawa
Y, Mizuno S, Yagami KI, Ishikawa C, Li H, Shiga T, Ishida J, Hamada J, Murata K, Ishimaru T,
Hashimoto M, Fukamizu A, Yamane M, Ikawa M, Morita H, Shinohara M, Asahara
H, Akiyama T, Akiyama N, Sasanuma H, Yoshida N, Zhou R, Wang YY, Ito T,
Kokubu Y, Noguchi TK, Ishimine H, Kurisaki A, Shiba D, Mizuno H, Shirakawa
M, Ito N, Takeda S, Takahashi S. Exp Anim. 2016 May 20;65(2):175-87. doi: 10.1538/expanim.15-0077.
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced
arthritis in mice
Ohmi Y, Ise W, Harazono A, Takamura D, Fukuyama H, Baba Y, Narazaki M,
Shoda H, Takahashi N, Ohkawa Y, Shuting Ji, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y,
Furukawa K Nat Commun. 2016 Apr 5;7:11205. doi: 10.1038/ncomms11205.
Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to
mediate lineage-specific programs.
Ohmura S, Mizuno S, Oishi H, Ku CJ, Hermann M, Hosoya T, Takahashi S, Engel JD. J Clin Invest. 2016 Mar 1;126(3):865-78. doi: 10.1172/JCI83894.
β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F, Takahashi S. PLoS One. 2016 Feb 22;11(2):e0150010. doi: 10.1371/journal.pone.0150010. eCollection
2016.
2015
Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional
Activity in T Lymphocytes.
Onodera A, Tumes DJ, Watanabe Y, Hirahara K, Kaneda A, Sugiyama F, Suzuki Y, Nakayama T. Mol Cell Biol. 2015 Nov 15;35(22):3841-53.
Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically
Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent
Stem Cells. Iseki H, Nakachi Y, Hishida T, Yamashita-Sugahara Y, Hirasaki M, Ueda A, Tanimoto
Y, Iijima S, Sugiyama F, Yagami KI, Takahashi S, Okuda A, Okazaki Y. Stem Cells. 2015 Nov 2. doi: 10.1002/stem.2243.
Peri-implantation lethality in mice carrying megabase-scale deletion on
5qc3.3 is caused by Exoc1 null mutation. Mizuno S, Takami K, Daitoku Y, Tanimoto Y, Dinh TT, Mizuno-Iijima S, Hasegawa Y, Takahashi S, Sugiyama F, Yagami K. Sci Rep. 2015 Sep 8;5:13632.
Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive
Pathways.
Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, Fukamizu A. PLoS One. 2015 Jun 24;10(6):e0129484.
A mouse renin distal enhancer is essential for blood pressure homeostasis
in BAC-rescued renin-null mutant mice.
Tanimoto K, Kanafusa S, Ushiki A, Matsuzaki H, Ishida J, Sugiyama F, Fukamizu A. J Recept Signal Transduct Res. 2014 Oct;34(5):401-9.
p38 Mitogen-activated protein kinase accelerates emphysema in mouse model
of chronic obstructive pulmonary disease.
Amano H, Murata K, Matsunaga H, Tanaka K, Yoshioka K, Kobayashi T, Ishida
J, Fukamizu A, Sugiyama F, Sudo T, Kimura S, Tatsumi K, Kasuya Y. J Recept Signal Transduct Res. 2014 Aug;34(4):299-306.
Simple generation of albino C57BL/6J mice with G291T mutation in the tyrosinase
gene by the CRISPR/Cas9 system. Mizuno S, Tra DT, Kato K, Iijima S, Tanimoto Y, Daitoku Y, Hoshino Y, Ikawa M, Takahashi S, Sugiyama F, and Yagami K. Mamm Genome. 2014 Aug;25(7-8):327-34.
Truncated Cales1 causes agenesis of the corpus callosum in mice. Mizuno S, Tra DT, Mizobuchi A, Iseki H, Iijima S, Kim JD, Ishida J, Matsuda Y, Kunita S, Fukamizu A, Sugiyama F, Yagami K. Lab Invest. 2014 Mar;94(3):321-30.
Role of retinoic acid and fibroblast growth factor 2 in neural differentiation
from cynomolgus monkey (macaca fascicularis) embryonic stem cells.
Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T. Comp Med. 2014 Apr;64(2):140-7.
Generation and characterization of Ins1-cre-driver C57BL/6N for exclusive
pancreatic beta cell-specific Cre-loxP recombination. Hasegara Y, Daitoku Y, Mizuno S, Tanimoto Y, Iijima S, Matsuo M, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S,
Sugiyama F, Yagami K. Exp Anim. 2014;63(2):183-91.
2013
Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission
before and red emission after Cre-mediated recombination. Hasegara Y, Daitoku Y, Sekiguchi K, Tanimoto Y, Iijima S, Mizuno S, Kajiwara N, Ema M, Oishi H, Miwa Y, Mekada K, Yoshiki A, Takahashi S,
Sugiyama F, Yagami K. Exp Anim. 2013;62(4):295-304.
Effect of lactation on postpartum cardiac function of pregnancy-associated
hypertensive mice.
Murata K, Saito C, Ishida J, Hamada J, Sugiyama F, Yagami K, Fukamizu A. Endocrinology. 2013 Feb;154(2):597-602.
2012
Nrf2 in bone marrow-derived cells positively contributes to the advanced
stage of atherosclerotic plaque formation.
Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami K, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K. Free Radic Biol Med. 2012 Dec 15;53(12):2256-62.
Short-term suppression of the renin-angiotensin system in mice associated
with hypertension during pregnancy.
Ishimaru T, Ishida J, Nakamura S, Hashimoto M, Matsukura T, Nakamura A,
Kunita S, Sugiyama F, Yagami K, Fukamizu A. Mol Med Rep. 2012 Jul;6(1):28-32.