研究業績：2021年

Gao Q, Dong JY, Cui R, Muraki I, Yamagishi K, Sawada N, Iso H, Tsugane S; Japan Public Health Center-based Prospective Study Group. Consumption of flavonoid-rich fruits, flavonoids from fruits and stroke risk: a prospective cohort study. Br J Nutr 2021 Dec 14;126(11):1717-1724. doi: 10.1017/S0007114521000404. Epub 2021 Jan 29. PMID: 33509322.

Ota A, Li Y, Yatsuya H, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Arima K, Sou Y, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Sawada N, Tsugane S; JPHC-NEXT Study Group. Working cancer survivors' physical and mental characteristics compared to cancer-free workers in Japan: a nationwide general population-based study. J Cancer Surviv 2021 Dec;15(6):912-921. doi: 10.1007/s11764-020-00984-7. Epub 2021 Jan 12. PMID: 33433855; PMCID: PMC8519890.

Kakihana H, Jinnouchi H, Kitamura A, Matsudaira K, Kiyama M, Hayama-Terada M, Muraki I, Kubota Y, Yamagishi K, Okada T, Imano H, Iso H. Overweight and Hypertension in Relation to Chronic Musculoskeletal Pain Among Community-Dwelling Adults: The Circulatory Risk in Communities Study (CIRCS). J Epidemiol 2021 Nov 5;31(11):566-572. doi: 10.2188/jea.JE20200135. Epub 2021 Feb 18. PMID: 32801279; PMCID: PMC8502830.

Ikehara S, Iso H, Kokubo Y, Yamagishi K, Saito I, Yatsuya H, Kimura T, Sawada N, Iwasaki M, Tsugane S; JPHC Study Group. Peanut Consumption and Risk of Stroke and Ischemic Heart Disease in Japanese Men and Women: The JPHC Study. Stroke 2021 Nov;52(11):3543-3550. doi: 10.1161/STROKEAHA.120.031212. Epub 2021 Sep 9. PMID: 34496618.

GBD 2019 Adolescent Mortality Collaborators. Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet 2021; 398:1593-1618.

Gao Q, Eshak ES, Muraki I, Shirai K, Yamagishi K, Tamakoshi A, Iso H. The apparent inverse association between dietary carotene intake and risk of cardiovascular mortality disappeared after adjustment for other cardioprotective dietary intakes: The Japan collaborative cohort study. Nutr Metab Cardiovasc Dis 2021 Oct 28;31(11):3064-3075. doi: 10.1016/j.numecd.2021.07.026. Epub 2021 Jul 30. PMID: 34629253.

Wang X, Dong JY, Shirai K, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Iso H, Tsugane S, Sawada N; Japan Public Health Center-based Prospective Study Group. Having hobbies and the risk of cardiovascular disease incidence: A Japan public health center-based study. Atherosclerosis 2021 Oct;335:1-7. doi: 10.1016/j.atherosclerosis.2021.09.002. Epub 2021 Sep 3. PMID: 34517285.

GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 2021 Oct;20(10):795-820. doi: 10.1016/S1474-4422(21)00252-0. Epub 2021 Sep 3. PMID: 34487721; PMCID: PMC8443449.

GBD 2019 Under-5 Mortality Collaborators. Global, regional, and national progress towards Sustainable Development Goal 3.2 for neonatal and child health: all-cause and cause-specific mortality findings from the Global Burden of Disease Study 2019. Lancet 2021 Sep 4;398(10303):870-905. doi: 10.1016/S0140-6736(21)01207-1. Epub 2021 Aug 17. PMID: 34416195; PMCID: PMC8429803.

Aoki S, Yamagishi K, Maruyama K, Kishida R, Ikeda A, Umesawa M, Renzhe C, Kubota Y, Hayama-Terada M, Shimizu Y, Muraki I, Imano H, Sankai T, Okada T, Kitamura A, Kiyama M, Iso H. Dietary intake of tocopherols and risk of incident disabling dementia. Sci Rep 2021 Aug 12;11(1):16429. doi:10.1038/s41598-021-95671-7. PMID: 34385499; PMCID: PMC8361201.

Sasaki Y, Abe Y, Shoji M, Mizumoto N, Takeda H, Oizumi H, Yaoita T, Sawada N, Yamagishi K, Saito E, Watanabe M, Ishizawa K, Konta T, Kayama T, Tsugane S, Ueno Y, Inoue M. Reliability of self-reported questionnaire for epidemiological investigation of Helicobacter pylori eradication in a population-based cohort study. Sci Rep 2021 Aug 2;11(1):15605. doi: 10.1038/s41598-021-95124-1. PMID: 34341428; PMCID: PMC8329205.

Yamanishi R, Sawada N, Hanyuda A, Uchino M, Kawashima M, Yuki K, Tsubota K, Kato T, Saito I, Arima K, Mizukami S, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Tsugane S; JPHC-NEXT Group. Relation Between Body Mass Index and Dry Eye Disease: The Japan Public Health Center-Based Prospective Study for the Next Generation. Eye Contact Lens 2021 Aug 1;47(8):449-455. doi: 10.1097/ICL.0000000000000814. PMID: 34310488.

GBD 2019 Collaborators. Global mortality from dementia: Application of a new method and results from the Global Burden of Disease Study 2019. Alzheimers Dement: TRCI 2021; 7:e12200.

Wang H, Lu H, Zhang XM, Goto KI, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Iwadate Y, Mine S, Machida T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kamitsukasa I, Wada T, Aotsuka A, Sugimoto K, Takizawa H, Kashiwado K, Shin H, Tomiyoshi G, Nakamura R, Shinmen N, Kuroda H, Xu A, Hiwasa T. Association of serum levels of antibodies against ALDOA and FH4 with transient ischemic attack and cerebral infarction. BMC Neurol 2021 Jul 9;21(1):274. doi: 10.1186/s12883-021-02301-w. PMID: 34243715; PMCID: PMC8268454.

Li SY, Yoshida Y, Kobayashi E, Kubota M, Matsutani T, Mine S, Machida T, Maezawa Y, Takemoto M, Yokote K, Kobayashi Y, Takizawa H, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kobayashi S, Matsushita K, Nomura F, Matsubara H, Sumazaki M, Ito M, Yajima S, Shimada H, Iwase K, Ashino H, Wang H, Goto K, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y, Hiwasa T. Serum anti-AP3D1 antibodies are risk factors for acute ischemic stroke related with atherosclerosis. Sci Rep 2021 Jun 29;11(1):13450. doi: 10.1038/s41598-021-92786-9. PMID: 34188129; PMCID: PMC8242008.

Hiwasa T, Wang H, Goto KI, Mine S, Machida T, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Sata M, Yamagishi K, Iso H, Sawada N, Tsugane S, Kunimatsu M, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Muto M, Kuwabara S, Kobayashi Y, Ohno M, Nishi E, Hattori A, Yamamoto M, Maezawa Y, Kobayashi K, Ishibashi R, Takemoto M, Yokote K, Takizawa H, Kishimoto T, Matsushita K, Kobayashi S, Nomura F, Arasawa T, Kagaya A, Maruyama T, Matsubara H, Tomiita M, Hamanaka S, Imai Y, Nakagawa T, Kato N, Terada J, Matsumura T, Katsumata Y, Naito A, Tanabe N, Sakao S, Tatsumi K, Ito M, Shiratori F, Sumazaki M, Yajima S, Shimada H, Shirouzu M, Yokoyama S, Kudo T, Doi H, Iwase K, Ashino H, Li SY, Kubota M, Tomiyoshi G, Shinmen N, Nakamura R, Kuroda H, Iwadate Y. Serum anti-DIDO1, anti-CPSF2, and anti-FOXJ2 antibodies as predictive risk markers for acute ischemic stroke. BMC Med 2021 Jun 9;19(1):131. doi: 10.1186/s12916-021-02001-9. PMID: 34103026; PMCID: PMC8188684.

GBD 2019 Chewing Tobacco Collaborators. Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet Public Health 2021 Jul;6(7):e482-e499. doi: 10.1016/S2468-2667(21)00065-7. Epub 2021 May 28. Erratum in: Lancet Public Health. 2021 Jul;6(7):e449. PMID: 34051920; PMCID: PMC8251505.

GBD 2019 Tobacco Collaborators. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019. Lancet 2021 Jun 19;397(10292):2337-2360. doi: 10.1016/S0140-6736(21)01169-7. Epub 2021 May 27. Erratum in: Lancet. 2021 Jun 19;397(10292):2336. PMID: 34051883; PMCID: PMC8223261.

Hanyuda A, Sawada N, Uchino M, Kawashima M, Yuki K, Tsubota K, Tanno K, Sakata K, Yamagishi K, Iso H, Yasuda N, Saito I, Kato T, Abe Y, Arima K, Shimazu T, Yamaji T, Goto A, Inoue M, Iwasaki M, Tsugane S. Relationship between unhealthy sleep status and dry eye symptoms in a Japanese population: The JPHC-NEXT study. Ocul Surf 2021 Jul;21:306-312. doi: 10.1016/j.jtos.2021.04.001. Epub 2021 Apr 18. PMID: 33845221.

Shimoda S, Kitamura A, Imano H, Cui R, Muraki I, Yamagishi K, Umesawa M, Sankai T, Hayama-Terada M, Kubota Y, Shimizu Y, Okada T, Kiyama M, Iso H. Associations of Carotid Intima-Media Thickness and Plaque Heterogeneity With the Risks of Stroke Subtypes and Coronary Artery Disease in the Japanese General Population: The Circulatory Risk in Communities Study. J Am Heart Assoc 2020 Oct 20;9(19):e017020. doi: 10.1161/JAHA.120.017020. Epub 2020 Sep 29. PMID: 32990124; PMCID: PMC7792402.

Jinnouchi H, Matsudaira K, Kitamura A, Kakihana H, Oka H, Hayama-Terada M, Yamagishi K, Kiyama M, Iso H; CIRCS Investigators. Effects of brief self-exercise education on the management of chronic low back pain: A community-based, randomized, parallel-group pragmatic trial. Mod Rheumatol 2021 Jul;31(4):890-898. doi: 10.1080/14397595.2020.1823603. Epub 2020 Oct 9. PMID: 32930621.

Nozue M, Shimazu T, Charvat H, Mori N, Mutoh M, Sawada N, Iwasaki M, Yamaji T, Inoue M, Kokubo Y, Yamagishi K, Iso H, Tsugane S. Fermented soy products intake and risk of cardiovascular disease and total cancer incidence: The Japan Public Health Center-based Prospective study. Eur J Clin Nutr 2021 Jun;75(6):954-968. doi: 10.1038/s41430-020-00732-1. Epub 2020 Sep 4. PMID: 32887936.

Li Y, Cui R, Liu K, Eshak ES, Cui M, Dong J, Imano H, Muraki I, Kiyama M, Kitamura A, Okada T, Yamagishi K, Umesawa M, Ohira T, Iso H; CIRCS investigators. Relationship between Endothelial Dysfunction and Prevalence of Chronic Kidney Disease: The Circulatory Risk in Communities Study (CIRCS). J Atheroscler Thromb 2021 Jun 1;28(6):622-629. doi: 10.5551/jat.56424. Epub 2020 Sep 2. PMID: 32879150; PMCID: PMC8219532.

Kihara T, Yamagishi K, Honda K, Ikeda A, Yatsuya H, Saito I, Kokubo Y, Yamaji T, Shimazu T, Sawada N, Iwasaki M, Iso H, Tsugane S; JPHC Study Group. Apolipoprotein A2 Isoforms in Relation to the Risk of Myocardial Infarction: A Nested Case-Control Analysis in the JPHC Study. J Atheroscler Thromb 2021 May 1;28(5):483-490. doi: 10.5551/jat.56218. Epub 2020 Aug 29. PMID: 32863295; PMCID: PMC8193784.

Kudo A, Kitamura A, Imano H, Cui R, Umesawa M, Yamagishi K, Ohira T, Muraki I, Hayama-Terada M, Kiyama M, Iso H; for CIRCS Investigators. Salt taste perception and blood pressure levels in population-based samples: the Circulatory Risk in Communities Study (CIRCS). Br J Nutr 2021 Jan 28;125(2):203-211. doi: 10.1017/S0007114520002640. Epub 2020 Aug 20. PMID: 32814612.

Takada M, Yamagishi K, Tamakoshi A, Iso H; JACC Study Group. Body Mass Index and Mortality From Aortic Aneurysm and Dissection. J Atheroscler Thromb 2021 Apr 1;28(4):338-348. doi: 10.5551/jat.57232. Epub 2020 Jul 28. PMID: 32727971; PMCID: PMC8147012.

Li J, Imano H, Yamagishi K, Cui R, Muraki I, Umesawa M, Hayama-Terada M, Ohira T, Kiyama M, Okada T, Sankai T, Tanigawa T, Kitamura A, Iso H; CIRCS Investigators. Serum Albumin and Risks of Stroke and Its Subtypes　- The Circulatory Risk in Communities Study (CIRCS). Circ J. 2021 Mar 25;85(4):385-392. doi: 10.1253/circj.CJ-20-0384. Epub 2020 Nov 13. PMID: 33191391.

Aketa N, Uchino M, Kawashima M, Uchino Y, Yuki K, Ozawa Y, Sasaki M, Yamagishi K, Sawada N, Tsugane S, Tsubota K, Iso H. Myopia, corneal endothelial cell density and morphology in a Japanese population-based cross-sectional study: the JPHC-NEXT Eye Study. Sci Rep 2021 Mar 18;11(1):6366. doi: 10.1038/s41598-021-85617-4. PMID: 33737603; PMCID: PMC7973534.

Saito E, Inoue M, Sawada N, Kokubo Y, Yamagishi K, Iso H, Shimazu T, Yamaji T, Iwasaki M, Tsugane S; JPHC Study Group. Risk of stroke in cancer survivors using a propensity score-matched cohort analysis. Sci Rep 2021 Mar 10;11(1):5599. doi: 10.1038/s41598-021-83368-w. PMID: 33692383; PMCID: PMC7946896.

Sairenchi T, Yamagishi K, Iso H, Irie F, Koba A, Nagao M, Umesawa M, Haruyama Y, Takaoka N, Watanabe H, Kobashi G, Ota H. Atrial Fibrillation With and Without Cardiovascular Risk Factors and Stroke Mortality. J Atheroscler Thromb 2021 Mar 1;28(3):241-248. doi: 10.5551/jat.53629. Epub 2020 Jun 18. PMID: 32554949.

Teramoto M, Muraki I, Yamagishi K, Tamakoshi A, Iso H. Green Tea and Coffee Consumption and All-Cause Mortality Among Persons With and Without Stroke or Myocardial Infarction. Stroke 2021 Mar;52(3):957-965. doi: 10.1161/STROKEAHA.120.032273. Epub 2021 Feb 4. PMID: 33535784; PMCID: PMC7903984.

Kisanuki K, Muraki I, Yamagishi K, Kokubo Y, Saito I, Yatsuya H, Sawada N, Iso H, Tsugane S; JPHC Study Group. Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center-based Prospective Study. Atherosclerosis 2021 Feb 23;322:67-73. doi: 10.1016/j.atherosclerosis.2021.02.017. Epub ahead of print. PMID: 33743510.

Ikeda S, Ikeda A, Yamagishi K, Hori M, Kubo S, Sata M, Okada C, Umesawa M, Sankai T, Kitamura A, Kiyama M, Ohira T, Tanigawa T, Iso H. Longitudinal Trends in Blood Pressure Associated With the Frequency of Laughter: The Circulatory Risk in Communities Study (CIRCS), a Longitudinal Study of the Japanese General Population. J Epidemiol 2021 Feb 5;31(2):125-131. doi: 10.2188/jea.JE20190140. Epub 2020 Feb 22. PMID: 32092749; PMCID: PMC7813767.

Tanaka M, Imano H, Kubota Y, Yamagishi K, Umesawa M, Muraki I, Cui R, Hayama- Terada M, Shimizu Y, Okada T, Ohira T, Sankai T, Tanigawa T, Sato S, Kitamura A, Kiyama M, Iso H; and the CIRCS Investigators. Serum High-Sensitivity C-Reactive Protein Levels and the Risk of Atrial Fibrillation in Japanese Population: the Circulatory Risk in Communities Study. J Atheroscler Thromb 2021 Feb 1;28(2):194-202. doi: 10.5551/jat.54064. Epub 2020 Jun 10. PMID: 32522907; PMCID: PMC7957035.

Kudo A, Kitamura A, Imano H, Cui R, Umesawa M, Yamagishi K, Ohira T, Muraki I, Hayama-Terada M, Kiyama M, Iso H; for CIRCS Investigators. Salt taste perception and blood pressure levels in population-based samples: the Circulatory Risk in Communities Study (CIRCS). Br J Nutr 2021 Jan 28;125(2):203-211. doi: 10.1017/S0007114520002640. Epub 2020 Aug 20. PMID: 32814612.

Sata M, Cui R, Chiang C, Singeo ST Jr, Watson BM, Yatsuya H, Honjo K, Mita T, Temengil EJ, Madraisau S, Yamagishi K, Aoyama A, Iso H. Determinants of alcohol consumption and marijuana use among young adults in the Republic of Palau. Environ Health Prev Med 2021 Jan 22;26(1):12. doi: 10.1186/s12199-020-00928-8. PMID: 33482714.

Wada H, Ikeda A, Maruyama K, Yamagishi K, Barnes PJ, Tanigawa T, Tamakoshi A, Iso H. Low BMI and weight loss aggravate COPD mortality in men, findings from a large prospective cohort: the JACC study. Sci Rep 2021 Jan 15;11(1):1531. doi: 10.1038/s41598-020-79860-4. PMID: 33452329; PMCID: PMC7810869.

Eshak ES, Muraki I, Imano H, Yamagishi K, Tamakoshi A, Iso H. Manganese intake from foods and beverages is associated with a reduced risk of type 2 diabetes. Maturitas 2021 Jan;143:127-131. doi: 10.1016/j.maturitas.2020.10.009. Epub 2020 Oct 19. PMID: 33308618.

Kusama Y, Ishikane M, Kihara T, Ohmagari N. Epidemiology of antibiotic treatment for uncomplicated cystitis in adults in Japan. J Infect Chemother 2021 Jan;27(1):113-116. doi: 10.1016/j.jiac.2020.09.001. Epub 2020 Oct 1. PMID: 33011067.

英文総説

Umesawa M, Yamagishi K, Iso H. Intake of fish and long-chain n-3 polyunsaturated fatty acids and risk of diseases in a Japanese population: a narrative review. Eur J Clin Nutr 2021 Jun;75(6):902-920. doi: 10.1038/s41430-020-00751-y. Epub 2020 Sep 16. PMID: 32939045.

Murai U, Yamagishi K, Kishida R, Iso H. Impact of seaweed intake on health. Eur J Clin Nutr 2021 Jun;75(6):877-889. doi: 10.1038/s41430-020-00739-8. Epub 2020 Sep 9. Erratum in: Eur J Clin Nutr. 2020 Oct 15;: PMID: 32908248.

著書

佐田みずき，山岸良匡，岡村智教．血清総コレステロール値と脂質異常症の動向．三浦克之，大久保孝義，編．循環器病予防エビデンスブック Vol.1．東京：医歯薬出版，2021 p.149-156

髙田碧，木原朋未，磯博康．大動脈疾患の動向．三浦克之，大久保孝義，編．循環器病予防エビデンスブック Vol.1．東京：医歯薬出版，2021 p.120-126

山岸良匡，岸田里恵，磯博康．JACC Studyにより明らかになった日本人における食事・栄養に関する知見．玉腰暁子，編．JACC Study これまでの成果とあゆみ．津：予防医学広報事業団（青木平八郎・國雄記念），2021 p.127-136

Iso H, Maruyama K, Yamagishi K. Chronic diseases and risk factor trends in Japan. In: Brunner E, Cable N, Iso H, editors. Health in Japan: Social epidemiology of Japan since the 1964 Tokyo Olympics. Oxford: Oxford University Press, 2021 p.163-178.