2020年 6月 5日
HHEX promotes myeloid transformation in cooperation with mutant ASXL1
ポイント
• Mutant ASXL1 and HHEX promote myeloid leukemogenesis via upregulating the expression of MYB and ETV5. • Inhibition of the HHEX-MYB/ETV5 axis would be a promising therapeutic approach for myeloid malignancies harboring ASXL1 mutations.
→ Journal - Blood 2019 :blood.2019004613