土屋尚之 | 筑波大学分子遺伝疫学研究室

土屋尚之Naoyuki Tsuchiya

土屋尚之
(SP studio により作成)

略歴

2023年4月: 筑波大学医学医療系客員研究員
2011年10月: 筑波大学医学医療系教授(組織改編による名称変更)
2006年10月: 筑波大学大学院人間総合科学研究科社会環境医学専攻教授
1997年8月: 東京大学大学院医学系研究科人類遺伝学分野助教授
1996年6月: 東京大学大学院医学系研究科人類遺伝学分野助手
1990年8月: 東京大学医学部内科物理療法学教室助手
1988年5月: Research fellow University of Florida, Department of Medicine
1987年7月: Research fellow University of New Mexico, Department of Medicine
1985年6月: 東京大学医学部内科物理療法学教室（物療内科）医員
1983年3月: 東京大学医学部医学科卒業

主な学会関連役職

日本リウマチ学会評議員（2007年～現在）
日本組織適合性学会評議員（2008年～現在）

Associate Editor

Journal of Human Genetics（2014年1月～現在）

Editorial board

Genes and Immunity（2000年～現在）
Journal of Human Genetics（2007年1月～2013年12月）

編集協力者

医学のあゆみ（2001年～現在）

編集アドバイザー

炎症と免疫（2012年～現在）

受賞・研究助成

2021年度上原記念生命科学財団研究助成金
第52回(2020年度）内藤記念科学奨励金・研究助成
2018年度ブリストル・マイヤーズ　スクイブ株式会社研究助成
平成29年度日本リウマチ財団ノバルティス・リウマチ医学賞
平成27年度日本リウマチ学会賞
公益財団法人先進医薬研究振興財団平成24年度（第31回）血液医学分野一般研究助成
公益財団法人日本アレルギー協会平成23年度真鍋奨学助成
財団法人先進医薬研究振興財団平成20年度(第27回)血液医学分野一般研究助成
第30回内藤記念科学奨励金（内藤記念科学振興財団）（平成19年）
日本リウマチ財団三浦記念リウマチ学術研究賞
2004年度武田科学振興財団医学系研究奨励
平成8年度上原記念生命科学財団研究奨励金
平成6年度持田記念医学薬学振興財団研究奨励賞
平成5年度慢性疾患・リハビリテイション研究振興財団研究助成金
平成4年度北陸製薬・関節疾患学術奨励賞
平成2年度日本リウマチ財団リウマチ性疾患調査・研究助成費

Google Scholar Citations

Naoyuki Tsuchiya

TRIOS

筑波大学研究者総覧　土屋尚之(ツチヤナオユキ; Tsuchiya, Naoyuki)

研究業績

英文原著 (corresponding authorを*で示す)

Kawasaki A*, Kusumawati PA, Kawamura Y, Kondo Y, Kusaoi M, Amano H, Kusanagi Y, Itoh K, Fujimoto T, Tamura N, Hashimoto H, Matsumoto I, Sumida T, Tsuchiya N*. Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: Primary role for HLA-DRB1*15:01. RMD Open 2023;9:e003214. doi: 10.1136/rmdopen-2023-003214
Kawasaki A*, Kusumawati PA, Kawamura Y, Kondo Y, Kusaoi M, Amano H, Kusanagi Y, Itoh K, Fujimoto T, Tamura N, Hashimoto H, Matsumoto I, Sumida T, Tsuchiya N*. Genetic dissection of HLA-DRB1*15:01 and XL9 region variants in Japanese patients with systemic lupus erythematosus: Primary role for HLA-DRB1*15:01[PREPRINT]. medRxiv 2023.04.05.23288103; doi: https://doi.org/10.1101/2023.04.05.23288103
Kawasaki A*, Sada K-E, Kusumawati PA, Hirano F, Kobayashi S, Nagasaka K, Sugihara T, Ono N, Fujimoto T, Kusaoi M, Tamura N, Kusanagi Y, Itoh K, Sumida T, Yamagatam K, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N*. Association of HLA-class II alleles with risk of relapse in myeloperoxidase-antineutrophil cytoplasmic antibody positive vasculitis in the Japanese population. Front Immunol 2023; 14:1119064. doi: 10.3389/fimmu.2023.1119064
Kawasaki A*, Namba N, Sada K-e, Hirano F, Kobayashi S, Nagasaka K, Sugihara T, Ono N, Fujimoto T, Kusaoi M, Tamura N, Yamagata K, Sumida T, Hashimoto H, Ozaki S, Makino H, Arimura Y, Harigai M, Tsuchiya N*. Association of TERT and DSP variants with microscopic polyangiitis and myeloperoxidase-ANCA positive vasculitis in a Japanese population: a genetic association study Arthritis Res Ther 2020 October 16, 22(1):246. doi: 10.1186/s13075-020-02347-0.
Yamashita K, Kawasaki A, Matsushita T, Furukawa H, Kondo Y, Okiyama N, Nagaoka S, Shimada K, Sugii S, Katayama M, Hirohata S, Okamoto A, Chiba N, Suematsu E, Setoguchi K, Migita K, Sumida T, Tohma S, Hamaguchi Y, Hasegawa M, Sato S, Kawaguchi Y, Takehara K, Tsuchiya N*. Association of functional (GA)n microsatellite polymorphism in the FLI1 gene with susceptibility to human systemic sclerosis. Rheumatology 2020 Jul 22, keaa306, https://doi.org/10.1093/rheumatology/keaa306[Online ahead of print]
Higuchi T, Yoshimura M, Oka S, Tanaka K, Naito T, Yuhara S, Warabi E, Mizuno S, Ono M, Takahashi S, Tohma S, Tsuchiya N, Furukawa H*. Modulation of methotrexate-induced intestinal mucosal injury by dietary factors. Hum Exp Toxicol 2019 Dec 26:960327119896605. doi: 10.1177/0960327119896605. [Epub ahead of print]
Yokoyama N, Kawasaki A*, Matsushita T, Furukawa H, Kondo Y, Hirano F, Sada K-e, Matsumoto I, Kusaoi M, Amano H, Nagaoka S, Setoguchi K, Nagai T, Shimada K, Sugii S, Hashimoto A, Matsui T, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Migita K, Kono H, Hasegawa M, Kobayashi S, Yamada H, Nagasaka K, Sugihara T, Yamagata K, Ozaki S, Tamura N, Takasaki Y, Hashimoto H, Makino H, Arimura Y, Harigai M, Sato S, Sumida T, Tohma S, Takehara K, Tsuchiya N*. Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population. Sci Rep 2019; 9, 16366. doi:10.1038/s41598-019-52920-0
Oka S, Furukawa H*, Shimada K, Hashimoto A, Komiya A, Tsunoda S, Saisho K, Tsuchiya N, Katayama M, Shinohara S, Matsui T, Fukui N, Sano H, Migita K, Tohma S. Association of HLA-DRB1 genotype with younger age onset and elder age onset rheumatoid arthritis in Japanese populations. Medicine (Baltimore). 2019 Nov;98(48):e18218. doi: 10.1097/MD.0000000000018218.
Furukawa H*, Oka S, Kawasaki A, Hidaka M, Shimada K, Kondo Y, Ihata A, Matsushita T, Matsumoto T, Hashimoto A, Matsumoto I, Komiya A, Kobayashi K, Osada A, Katayama M, Okamoto A, Setoguchi K, Kono H, Hamaguchi Y, Matsui T, Fukui N, Tamura H, Takehara K, Nagaoka S, Sugii S, Sumida T, Tsuchiya N, Tohma S. Human leukocyte antigen in Japanese patients with idiopathic inflammatory myopathy.Mod Rheumatol. 2019 Jul 18 doi: 10.1080/14397595.2019.1637593. [Epub ahead of print].
Namba N, Kawasaki A*, Sada K-e, Hirano F, Kobayashi S, Yamada H, Furukawa H, Shimada K, Hashimoto A, Matsui T, Nagasaka K, Sugihara T, Suzuki A, Yamagata K, Sumida T, Tohma S, Homma S, Ozaki S, Hahimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N*, On behalf of Japan Research Committee of the Ministry of Health, Labour, and Welfare for Intractable Vasculitis (JPVAS). Association of MUC5B promoter polymorphism with interstitial lung disease in myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis.　Ann Rheum Dis Epub ahead of print:　doi:10.1136/annrheumdis-2018-214263
Juge P-A, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, Kannengiesser C, Ottaviani S, Oka S, Tohma S, Tsuchiya N, Rojas-Serrano J, González-Pérez MI, Mejía M, Buendía-Roldán I, Falfán-Valencia R, Ambrocio-Ortiz E, Manali E, Papiris SA, Karageorgas T, Boumpas D, Antoniou K, van Moorsel CHM, van der Vis J, de Man YA, Grutters JC, Wang Y, Borie R, Wemeau-Stervinou L, Wallaert B, Flipo RM, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Marchand-Adam S, Frazier A, Richette P, Allanore Y, Sibilia J, Dromer C, Richez C, Schaeverbeke T, Lioté H, Thabut G, Nathan N, Amselem S, Soubrier M, Cottin V, Clément A, Deane K, Walts AD, Fingerlin T, Fischer A, Ryu JH, Matteson EL, Niewold TB, Assayag D, Gross A, Wolters P, Schwarz MI, Holers M, Solomon J, Doyle T, Rosas IO, Blauwendraat C, Nalls MA, Debray MP, Boileau C, Crestani B, Schwartz DA*, Dieudé P*.MUC5B promoter variant and rheumatoid arthritis with interstitial lung disease. N Engl J Med 2018;379:2209-2219. doi: 10.1056/NEJMoa1801562
Fujita Y, Furukawa H, Asano T, Sato S, Yashiro M, Kobayashi H, Watanabe H, Suzuki E, Koga T, Shimizu T, Ueki Y, Eguchi K, Tsuchiya N, Kawakami A, Migita K*. HLA-DQB1 DPB1 alleles in Japanese patients with Adult-onset Still's disease. Mod Rheumatol 2018 Aug 23:1-15. doi: 10.1080/14397595.2018.1514999.
Oka S, Higuchi T, Furukawa H*, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A.Tsuchiya N†, Migita K† (†equal senior authors). Association of a single nucleotide polymorphism in TNIP1 with type 1 autoimmune hepatitis in the Japanese population. J Hum Genet 2018; 63:739–744. doi: 10.1038/s10038-018-0440-0.
Oka S, Furukawa H*, Yasunami M, Kawasaki A, Nakamura H, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Yamashita H, Ario K, Ohta H, Sakai H, Yabuuchi I, Takahashi A, Abe K, Yatsuhashi H, Tohma S, Ohira H, Tsuchiya N†, Migita K† (†equal senior authors). HLA-DRB1 and DQB1 alleles in Japanese type 1 autoimmune hepatitis: The predisposing role of the DR4/DR8 heterozygous genotype. PLoS One 2017;12(10):e0187325. doi: 10.1371/journal.pone.0187325.
Kawasaki A,Yamashita K, Hirano F, Sada KE, Tsukui D, Kondo Y, Kimura Y, Asako K, Kobayashi S, Yamada H, Furukawa H, Nagasaka K, Sugihara T, Yamagata K, Sumida T, Tohma S, Kono H, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M, Tsuchiya N*. Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population. J Hum Genet Published online 05 October 2017; doi:10.1038/s10038-017-0362-2
Asano T, Furukawa H, Sato S, Yashiro M, Kobayashi H, Watanabe H, Suzuki E, Ito T, Ubara Y, Kobayashi D, Iwanaga N, Izumi Y, Fujikawa K, Yamasaki S, Nakamura T, Koga T, Shimizu T, Umeda M, Nonaka F, Yasunami M, Ueki Y, Eguchi K, Tsuchiya N, Tohma S, Yoshiura KI, Ohira H, Kawakami A, Migita K*. Effects of HLA-DRB1 alleles on susceptibility and clinical manifestations in Japanese patients with adult onset Still’s disease. Arthritis Res Ther 2017;19:199. https://doi.org/10.1186/s13075-017-1406-x
Iwata K, Oka S, Tsuno H, Furukawa H*, Shimada K, Hashimoto A, Komiya A, Tsuchiya N, Katayama M, Tohma S.Biomarker for nontuberculous mycobacterial pulmonary disease in patients with rheumatoid arthritis: anti-glycopeptidolipid core antigen immunoglobulin A antibodies. Mod Rheumatol Published online: 06 Jul 2017, doi: 10.1080/14397595.2017.1336866.
Terao C*, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson H, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y*. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis Published Online First: 17 March 2017. doi: 10.1136/annrheumdis-2016-210645
Oka S, Furukawa H*, Shimada K, Hashimoto A, Komiya A, Fukui N, Tsuchiya N, Tohma S. Plasma miRNA expression profiles in rheumatoid arthritis associated interstitial lung disease. BMC Musculoskelet Disord 2017;18:21.
Higuchi T, Oka S,Furukawa H*, Nakamura M, Komori A, Abiru S, Nagaoka S, Hashimoto S, Naganuma A, Naeshiro N, Yoshizawa K, Shimada M, Nishimura H, Tomizawa M, Kikuchi M, Makita F, Yamashita H, Ario K, Yatsuhashi H, Tohma S, Kawasaki A, Ohira H, Tsuchiya N†, Migita K†.(†equal senior authors) Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1 J Hum Genet advance online publication 15 December 2016; doi: 10.1038/jhg.2016.155.
Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Wichukchinda N, Sawanpanyalert P, Patarapotikul J, Tsuchiya N,Ohashi J. Association of BAK1 single nucleotide polymorphism with a risk for dengue hemorrhagic fever. BMC Med Genet 2016;17(1):43. doi: 10.1186/s12881-016-0305-3.
Hachiya Y, Kawasaki A*, Oka S, Kondo Y, Ito S, Matsumoto, Kusaoi M, Amano H, Suda A, Setoguchi K, Nagai T, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Ohno S, Katayama M, Kono H, Hirohata S, Takasaki Y, Hashimoto H, Sumida T, Nagaoka S, Tohma S,Furukawa H, Tsuchiya N*. Association of HLA-G 3’untranslated region polymorphisms with systemic lupus erythematosus in a Japanese population: a case-control association study. PLoS ONE 2016; 11(6): e0158065. doi:10.1371/journal.pone.0158065.
Kawasaki A*†, Hasebe N†,Hidaka M, Hirano F, Sada K-e, Kobayashi S, Yamada H, Furukawa H, Yamagta K, Sumida T, Miyasaka N, Tohma S, Ozaki S, Matsuo S, Hashimoto H, Makino H, Arimura Y, Harigai M,Tsuchiya N*(†equal first authors). Protective role of HLA-DRB1*13:02 against microscopic polyangiitis and MPO-ANCA positive vasculitides in a Japanese population: a case-control study. PLoS ONE 2016; 11(5): e0154393. doi:10.1371/journal.pone.0154393.
Furukawa H*, Oka S, Kawasak A, Shimada K, Sugii S, Matsushita T, Hashimoto A, Komiya A, Fukui N, Kobayashi K, Osada A, Ihata A, Kondo Y, Nagai T, Setoguchi K, Okamoto A, Okamoto A, Chiba N, Suematsu E, Kono H, Katayama M, Hirohata S, Sumida T, Migita K, Hasegawa M, Fujimoto M, Sato S, Nagaoka S, Takehara K, Tohma S†, Tsuchiya N† (†equal senior authors). Human leukocyte antigen and systemic sclerosis in Japanese: The sign of the four independent protective alleles, DRB1*13:02, DRB1*14:06,DQB1*03:01, and DPB1*02:01. PLoS ONE 2016; 11 (4) : e0154255. doi:10.1371/journal.pone.0154255
Oka S, Furukawa H*, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Suda A, Tsunoda S, Ito S, Nakamura T, Saisho K, Sano H, Migita K, Nagaoka S, Tsuchiya N, Tohma S. Association of human leukocyte antigen alleles with chronic lung diseases in rheumatoid arthritis. Rheumatology 2016: doi:10.1093/rheumatology/kew025.
Furukawa H*, Oka S, Shimada K, Masuo K, Nakajima F, Funano S, Tanaka Y, Komiya A, Fukui N, Sawasaki T, Tadokoro K, Nose M, Tsuchiya N, Tohma S. Autoantibody profiles in collagen disease patients with interstitial lung disease (ILD): Antibodies to major histocompatibility complex class I-related chain A (MICA) as markers of ILD.Biomarker Insights 2015:10:63–73 doi:10.4137/BMIMI.S28209.
Kawasaki A, Furukawa H, Nishida N, Warabi E, Kondo Y, Ito S, Matsumoto I, Kusaoi M, Amano H, Suda A, Nagaoka S, Setoguchi K, Nagai T, Hirohata S, Shimada K, Sugii S, Okamoto A, Chiba N, Suematsu E, Tokunaga K, Takasaki Y, Hashimoto H, Sumida T, Tohma S, Tsuchiya N*.Association of functional polymorphisms in Interferon Regulatory Factor 2 (IRF2) with susceptibility to systemic lupus erythematosus: A case-control association study. PLoS ONE 2014 Oct 6;9(10): e109764. doi:10.1371/journal.pone.0109764.
Oka S, Furukawa H*, Kawasaki A, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Ito S, Nakamura T, Saisho K, Kayatama M, Tsunoda S, Sano H, Mighta K, Suda A, Nagaoka S, Tsuchiya N†, Tohma S† (†equal senior authors).Protective effect of the HLA-DRB1*13:02 allele in Japanese rheumatoid arthritis patients. PLoS One 2014 Jun 9;9(6):e99453. doi: 10.1371/journal.pone.0099453
Dang TN, Naka I, Sa-Ngasang A, Anantapreecha S, Chanama S, Wichukchinda N, Sawanpanyalert P, Patarapotikul J, Tsuchiya N A replication study confirms the association of GWAS-identified SNPs at MICB and PLCE1 in Thai patients with dengue shock syndrome. BMC Med Genet 2014 May 17;15(1):58. doi: 10.1186/1471-2350-15-58.
Furukawa H*, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S. HLA-DRB1*08:02 is associated with bucillamine-induced proteinuria in Japanese rheumatoid arthritis patients. Biomarker Insights 2014; 9: 23-28. doi: 10.4137/BMI.S13654
Furukawa H*,Kawasaki A, Oka S, Ito I, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Amano H, Nagai T, Hirohata S, Setoguchi K, Kono H, Okamoto A, Chiba N, Suematsu E, Katayama M, Migita K, Suda A, Ohno S, Hashimoto H, Takasaki Y, Sumida T, Nagaoka S, Tsuchiya N#, Tohma S#(#equal senior authors). Human leukocyte antigens and systemic lupus erythematosus: A protective role for the HLA-DR6 alleles DRB1*13:02 and *14:03. PLoS One. 2014 Feb 3;9(2):e87792. doi: 10.1371/journal.pone.0087792.
Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH (The CARDIOGENICS consortium), Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, NIicaise P, Amos C, Rodriguez-Rodriguez L, Chioccia G, Boileau C, Zhang J, Vittecoq O, Barnetche T, Gonzalez-Gay MA, Furukawa H, Cantagrel A, Le Loet X, Sumida T, Hurtado-Nedelec M, Richez C, Chollet-Martin S, Schaeverbeke T, Combe B, Khoriaty L, Coustet B, El-Benna J, Siminovitch K, Plenge R, Padyukov L, Martin J, Tsuchiya N, Dieude P*. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. Ann Rheum Dis Published Online First: 21st Jan 2014 doi:10.1136/annrheumdis-2013-204581
Kawasaki A, Inoue N, Ajimi C, Sada K, Kobayashi, Yamada H, Furukawa H, Sumida T, Tohma S, Miyasaka N, Matsuo S, Ozaki S, Hashimoto H, Makino H, Harigai M, Tsuchiya N*. Association of IRF5 polymorphism with MPO-ANCA positive vasculitis in a Japanese population. Genes Immun2013; 14: 527-529. doi: 10.1038/gene.2013.45.
Furukawa H*,Oka S, Takehana K, Muramatsu T, Shimada K, Komiya A, Fukui N, Tsuchiya N, Tohma S.Plasma amino acid profiles in collagen disease patients with interstitial lung disease. Immunome Res2013; 9: 064. doi: 10.4172/1745-7580.1000064
Oka S, Furukawa H*, Kashiwase K, Tsuchiya N, Tohma S. Novel HLA-DQB1*04 (DQB1*04:10) allele in the Japanese population. Tissue Antigens 2013; doi: 10.1111/tan.12135
Genin E, Coustet B, Allanore Y, Ito I, Teruel M, Constantin A, Schaeverbeke T, Adeline Ruyssens-Witran, Tohma S, Cantagrel A, Vittecoq O, Barnetche T, Le Loët X, Fardellone P, Furukawa H, Meyer O, Chiocchia G, Tsuchiya N, Martin J, Dieudé P.* Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis. PLoS One 2013; 8(4), e61044. doi:10.1371/journal.pone.0061044.
Oka S, Furukawa H*, Shimada K, Hayakawa H, Fukui N, Tsuchiya N, Tohma S. Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. BMC Immunol 2013:14,9. doi:10.1186/1471-2172-14-9
Furukawa H*, Kawasaki A, Oka S, Shimada K, Nakayama H, Matsui T, Ikenaka T, Hashimoto A, Okazaki Y, Takaoka H, Futami H, Komiya A, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Nagai T, Hirohata S, Setoguchi K, Nagaoka S, Kono H, Okamoto A, Fukui N, Hashimoto H, Sumida T, Ono M†, Tsuchiya N†, Tohma S.† (†equal senior author) Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus. Lupus 2013;22:497-503. doi: 10.1177/0961203313479421.
Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J*. A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. Int J Obes in press.
Umeda N, Matsumoto I*, Ito I, Kawasaki A, Tanaka Y, Inoue A, Tanaka Y, Tsuboi H, Suzuki T, Hayashi T, Ito S, Tsuchiya N, Sumida T. Identification of anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis. Clin Exp Immunol 2013;172:44-53.　doi: 10.1111/cei.12033.
Terao C*, Ohmura K*, Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N, Matsuda F, Mimori T. PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population.　Arthritis Rheum 2013;65(2):472-480.
Furukawa H*, Oka S, Matsui T, Hashimoto A, Arinuma Y, Komiya A, Fukui N, Tsuchiya N, Tohma S. Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus eythematosus. Hum Immunol 2013;74(2):170–175.
Furukawa H*, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S. Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosuspatients. PLoS One 2013; 8(1): e53910. doi:10.1371/journal.pone.0053910.
Furukawa H*, Oka S, Shimada K, Rheumatoid Arthritis associated Interstitial Lung Disease (RA-ILD) Study Consortium, Tsuchiya N, Tohma S. HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multi-drug hypersensitivity marker? Ann Rheum Dis 2013;72(1):153-155.
Hitomi Y, Adachi T, Tsuchiya N, Honda Z. Tokunaga K, Tsubata T*. Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum. BMC Immunol 2012:13,72. doi:10.1186/1471-2172-13-72
Oka S, Furukawa H*, Kashiwase K, Tsuchiya N, Tohma S. Identification of a novel HLA allele, HLA-DQB1*06:51, in a Japanese rheumatoid arthritis patient. Tissue Antigens 2012; 80, 386–387.
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N. Association of PHRF1-IRF7 region polymorphism with clinical phenotypes of systemic lupus erythematosus: an association study in a Japanese population. Lupus 2012;21(8):890-895.
Furukawa H*, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, Ikenaka T, Nakayama H, Hashimoto A, Takaoka H, Arinuma Y, Okazaki Y, Futami H, Komiya A, Fukui N, Nakamura T, Migita K, Suda A, Nagaoka S, Tsuchiya N†, Tohma S† (†equal senior author). Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: A protective role for shared epitope.PLoS One 2012;7(5): e33133. doi:10.1371/journal.pone.0033133
Hasebe N, Kawasaki A, Ito I, Kawamoto M, Hasegawa M, Fujimoto M, Furukawa H, Tohma S, Sumida T, Takehara K, Sato S, Kawaguchi Y, Tsuchiya N. Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population. Ann Rheum Dis 2012;71(7):1259-1260.
Furuya T, Koga M, Hikami K, Kawasaki A, Tsuchiya N*. Effects of APRIL (TNFSF13) polymorphisms and splicing isoforms on the secretion of soluble APRIL. Mod Rheumatol 2012; 22(4):541–549.
Kraisin S, Naka I, Patarapotikul J, Nantakomol D, Nuchnoi P, Hananantachai H, Tsuchiya N, Ohashi J*. Association of ADAMTS13 polymorphism with cerebral malaria. Malar J 2011;10:366 doi:10.1186/1475-2875-10-366
Koga M, Kawasaki A, Ito I, Furuya T, Ohashi J, Kyogoku C, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N*. Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female population. J Hum Genet 2011;56(7), 503-507. (The first two authors contributed equally to this work).
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N*. TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a　case-control association study. Arthritis Res Ther 2011;13:R41.
Hikami K, Kawasaki A, Ito I, Koga M, Ito S, Hayashi T, Matsumoto I, Tsutsumi A, Kusaoi M, Takasaki Y, Hashimoto H, Arinami T, Sumida T, Tsuchiya N*. Association of a functional polymorphism in the 3’ untranslated region of SPI1 with systemic lupus erythematosus. Arthritis Rheum 2011;63(3):755-763.
Ohashi J*, Naka I, Tsuchiya N. The impact of natural selection on an ABCC11 SNP determining earwax type. Mol Biol Evol 2011;28(1): 849-857
Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N*. Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study. Arthritis Res Ther 2010;12:R174 doi:10.1186/ar3134
Shen N*, Fu Q, Deng Y, Qian X, Zhao J, Kaufman KM, Wu YL, Yu CY, Tang Y, Chen J-Y, Yang W, Wong M, Kawasaki A, Tsuchiya N, Sumida T, Kawaguchi Y, Howe HS, Mok MY, Bang S-Y, Liu F-L, Chang D-M, Takasaki Y, Hashimoto H, Harley JB, Guthridge JM, Grossman JM, Cantor RM, Song YW, Bae S-C, Chen S, Hahn BH, Lau YL, Tsao BP*. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 2010;107:15838-15843.
Kawasaki A, Ito I, Ito S, Hayashi T, Goto D, Matsumoto I, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N*. Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population. J Biomed Biotechnol 2010; doi:10.1155/2010/207578
Ito I, Kawaguchi K, Kawasaki A, Hasegawa M, Ohashi J, Kawamoto M, Fujimoto M, Takehara K, Sato S, Hara M, Tsuchiya N*. Association of the FAM167A-BLK region with systemic sclerosis. Arthritis Rheum 2010;62:890-895.
Ito I, Kawasaki A, Ito S, Kondo Y, Sugihara M, Horikoshi M, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Takasaki Y, Hashimoto H, Matsuta K, Sumida T,Tsuchiya N. Replication of association between FAM167A(C8orf13)-BLK region and rheumatoid arthritis in a Japanese population. Ann Rheum Dis 2010;69:936-937. Published Online First: 9 September 2009. doi:10.1136/ard.2009.118760.
Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y, Nishida N, Tsuchiya N, Ohtsuka R, Ohashi J*. The Q223R polymorphism in LEPR is associated with obesity in the Pacific Islanders. Hum Genet 2010;127:287-294.
Naka I, Patarapotikul J, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J*. A replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai population. Malar J 2009;8:290.
Naka I, Nishida N, Patarapotikul J, Nuchnoi P, Tokunaga K, Hananantachai H, Tsuchiya N, Ohashi J*. Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria. Malar J 2009, 8:232.
Naka I, Patarapotikul J, Hananantachai H, Tokunaga K, Tsuchiya N, Ohashi J*. IFNGR1 polymorphisms in Thai malaria patients. Infect Genet Evol 2009;9:1406-1409.
Tsuchiya N*, Kawasaki A, Hasegawa M, Fujimoto M, Takehara K, Kawaguchi Y, Kawamoto M, Hara M, Sato S. Association of STAT4 polymorphism with systemic sclerosis in a Japanese population. Ann Rheum Dis 2009;68:1375-1376.
Ito I, Kawaguchi Y, Kawasaki A, Hasegawa M, Ohashi J, Hikami K, Kawamoto M, Fujimoto M, Takehara K, Sato S, Hara M, Tsuchiya N*. Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population. Arthritis Rheum 2009;60:1845-1850.
Kawaguchi Y*, Ota Y, Kawamoto M, Ito I, Tsuchiya N, Sugiura T, Katsumata Y, Soejima M, Sato S, Hasegawa M, Fujimoto M, Takehara K, Kuwana M, Yamanaka H, Hara M. Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population. Ann Rheum Dis 2009;68;1921-1924.
Ichikawa N*, Kotake S, Hakoda M, Higami K, Kawasaki A, Furuya T, Nanke Y, Tsuchiya N, Tokunaga K, Kamatani N.　Combining effects of polymorphism of tumor necrosis factor a 5'-flanking region and HLA-DRB1 on radiological progression in patients with rheumatoid arthritis.　Mod Rheumatol 2009;19:134-139.
Ito I, Kawasaki A, Ito S, Hayashi T, Goto D, Matsumoto I, Tsutsumi A, Hom G, Graham RR, Takasaki Y, Hashimoto H, Ohashi J, Behrens TW, Sumida T, Tsuchiya N. Replication of the association between C8orf13-BLK region and systemic lupus erythematosus in a Japanese population. Arthritis Rheum 2009: 60:553–558.
Furuya T*, Matsumoto I, Tsuchiya N, Hakoda M, Ichikawa N, Higami K, Nanke Y, Sumida T, Kamatani N, Kotake S. Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis. Clin Exp Rheumatol 2008;26:918-921.
Kawasaki A, Ito I, Hikami K, Ohashi J, Hayashi T, Goto D, Matsumoto I, Ito S, Tsutsumi A, Koga M, Arinami T, Graham RR, Hom G, Takasaki Y, Hashimoto H, Behrens TW, Sumida T, Tsuchiya N*. Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region. Arthritis Res Ther 2008;10:R113.
Hikami K, Ehara Y, Hasegawa M, Fujimoto M, Matsushita M, Oka T, Takehara K, Sato S, Tokunaga K, Tsuchiya N. Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosis. Biochem Biophys Res Commun 2008;373: 403-407.
Mamegano K, Kuroki K, Miyashita R, Kusaoi M, Kobayashi S, Matsuta K, Maenaka K, Colonna M, Ozaki S, Hashimoto H, Takasaki Y, Tokunaga K, Tsuchiya N. Association of LILRA2 (ILT1, LIR7) splice site polymorphism with systemic lupus erythematosus and microscopic polyangiitis.　Genes Immun　2008;9: 214–223.
Kawasaki A, Kyogoku C, Ohashi J, Miyashita R, Hikami K, Kusaoi M, Tokunaga K, Takasaki Y, Hashimoto H, Behrens TW, Tsuchiya N. Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population. Support for a crucial role of intron 1 polymorphisms Arthritis Rheum 2008;58: 826–834.
Furuya T*, Hakoda M, Ichikawa N, Higami K, Nanke Y, Yago T, Kobashigawa T, Tokunaga K, Tsuchiya N, Kamatani N, Kotake S. Differential association of HLA-DRB1 alleles in Japanese patients with early rheumatoid arthritis in relationship to autoantibodies to cyclic citrullinated peptide. Clin Exp Rheumatol 2007;25:219-224.
Hitomi Y, Tsuchiya N*, Hasegawa M, Fujimoto M, Takehara K, Tokunaga K, Sato S. Association of human CD22 gene polymorphism with susceptibility to limited cutaneous systemic sclerosis. Tissue Antigens 2007;69:242-249.
Kawasaki A, Tsuchiya N*, Ohashi J, Murakami Y, Fukazawa T, Kusaoi M, Matsuta K, Hashimoto H, Tokunaga K. Role of APRIL (TNFSF13) polymorphisms in the susceptibility to systemic lupus erythematosus in Japanese. Rheumatology 2007;46: 776-782.
Okaji Y*, Tsuno NH, Kitayama J, Sakurai D, Tsuchiya N, Saito S, Takegami K, Tsuchiya T, Kawai K, Yazawa K, Asakage M, Yoneyama S, Yamada J, Tokunaga K, Takahashi K, Nagawa H. Effects of Id (inhibitor of DNA binding/differentiation) gene down-regulation in human colorectal cancer cells on early steps of haematogenous metastasis. Eur J Cancer 2006;42:668-673.
Miyashita R, Tsuchiya N*, Yabe T, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K. Association of killer cell immunoglobulin-like receptor (KIR) genotypes with microscopic polyangiitis. Arthritis Rheum 2006;54;992-997.
Tsuchiya N*, Kobayashi S, Hashimoto H, Ozaki S, Tokunaga K. Association of HLA-DRB1 *0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese. Genes Immun 2006;7:81-84.
Tsuchiya T*, Okaji Y, Tsuno NH, Sakurai D, Tsuchiya N, Kawai K, Yazawa K, Asakage M, Yamada J, Yoneyama S, Kitayama J, Osada T, Watanabe T, Tokunaga K, Takahashi K, Nagawa H. Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. Cancer Sci 2005;96:784-790.
Kono H, Kyogoku C, Suzuki T, Tsuchiya N, Honda H, Yamamoto K, Tokunaga K, Honda Z*. FcgRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling. Hum Mol Genet 2005;14: 2881-2892.
Kuroki K, Tsuchiya N*, Shiroishi M, Rasubala L, Yamashita Y, Matsuta K, Fukazawa T, Kusaoi M, Murakami Y, Takiguchi M, Juji T, Hashimoto H, Kohda D, Maenaka K, Tokunaga K. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet 2005;14: 2469-2480.
Tanaka G*, Matsushita I, Ohashi J, Tsuchiya N, Ikushima S, Oritsu M, Hijikata M, Nagata T, Yamamoto K, Tokunaga K, Keicho N. Evaluation of microsatellite markers in association studies: a search for an immune-related susceptibility gene in sarcoidosis. Immunogenetics 2005;56:861-870.
Okaji Y*, Tsuno NH, Kitayama J, Saito S, Takahashi T, Kawai K, Yazawa K, Asakage M, Tsuchiya T, Sakurai D, Tsuchiya N, Tokunaga K, Takahashi K, Nagawa H. A novel method for isolation of endothelial cells and macrophages from murine tumors based on Ac-LDL uptake and CD16 expression. J Immunol ogical Methods 2004;295:183-193.
Ehara Y, Sakurai D, Tsuchiya N*, Nakano K, Tanaka Y, Yamaguchi A, Tokunaga K. Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility. Clin Exp Rheumatol 2004;22:707-712.
Tsuchiya N*, Kuroki K, Fujimoto M, Murakami Y, Tedder TF, Tokunaga K, Takehara K, Sato S. Association of functional CD19 polymorphism with susceptibility to systemic sclerosis. Arthritis Rheum 2004;50: 4002–4007.
Akesaka T, Lee SG, Ohashi J, Bannai M, Tsuchiya N, Yoon Y, Tokunaga K, Song K*. Comparative study of the haplotype structure and linkage disequilibrium of chromosome 1p36.2 region in the Korean and Japanese populations. J Hum Genet 2004;49: 603-609.
Hitomi Y, Tsuchiya N*, Kawasaki A, Kyogoku C, Ohashi J, Suzuki T, Fukazawa T, Bejrachandra S, Siriboonrit U, Chandanayingyong D, Suthipinittharm P, Tsao BP, Hashimoto H, Honda Z, Tokunaga K. CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2B. Hum Mol Genet 2004;13: 2907–2917.
Sakurai D, Tsuchiya N*, Yamaguchi A, Okaji Y, Tsuno NH, Kobata T, Takahashi K, Tokunaga K. Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cells. J Immunol 2004;173:5801-5809.
Mori K, Kizawa H, Ushiyama T, Chano T, Inoue H, Tsuchiya N, Matsusue Y, Okabe H, Ikegawa S*. Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese males. Am J Med Genet 2004;130A: 169-171.
Furuya T*, Hakoda M, Tsuchiya N, Kotake S, Ichikawa N, Nanke Y, Nakajima A, Takeuchi M, Nishinarita M, Kondo H, Kawasaki A, Kobayashi S, Mimori T, Tokunaga K, Kamatani N. Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathy. J Rheumatol 2004;31:1768-1774.
Sato-Takeda M, Ihn H, Ohashi J, Tsuchiya N, Satake M, Arita H, Tamaki K, Hanaoka K, Tokunaga K, Yabe T*. The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic neuralgia after herpes zoster. Pain 2004;110:329-336.
Hase H, Kanno Y, Kojima M, Hasegawa K, Sakurai D, Kojima H, Tsuchiya N, Tokunaga K, Masawa N, Azuma M, Okumura K, Kobata T*. BAFF/BLyS can potentiate B-cell selection with the B-cell co-receptor complex. Blood 2004;103:2257-2265.
Kyogoku C, Tsuchiya N*, Wu H, Tsao BP, Tokunaga K: Association of Fcg receptor IIA, but not of IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family-based association study in Caucasians. Arthritis Rheum 2004;50:671-673.
Miyashita R, Tsuchiya N*, Hikami K, Kuroki K, Fukazawa T, Bijl M, Kallenberg CGM, Hashimoto H, Yabe T, Tokunaga K. Molecular genetic analyses of human NKG2C (KLRC2) gene deletion. Int Immunol 2004;16:163-168.
Chu ZT, Tsuchiya N*, Kyogoku C, Ohashi J, Qian YP, Xu SB, Mao CZ, Chu JY, Tokunaga K. Association of Fcg receptor IIb polymorphism with susceptibility to systemic lupus erythematosus in Chinese: a common susceptibility gene in the Asian populations. Tissue Antigens 2004;63;21-27.
Karassa FB, Bijl M, Davies KA, Kallenberg CGM, Khamashta MA, Manger K, Michel M, Piette J-C, Salmon JE, Song YW, Tsuchiya N, Yoo D-H, Ioannidis JPA*.　Role of the FcgRIIA polymorphism in the antiphospholipid syndrome. An international meta-analysis. Arthritis Rheum 2003;48;1930-1938.
Tsuchiya N*, Kobayashi S, Kawasaki A, Kyogoku C, Arimura Y, Yoshida M, Tokunaga K, Hashimoto H. Genetic background of Japanese patients with ANCA-associated vasculitis: Association of HLA-DRB1*0901 with microscopic polyangiitis. J Rheumatol 2003;30:1534-1540.
Karassa FB, Trikalinos TA, Ioannidis JPA*, FcgRIIIA-SLE Meta-analysis Investigators. The FcgRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis. Kidney Int 2003;63: 1475-1482.
Siriboonrit U, Tsuchiya N*, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K. Association of Fcg receptor IIB, IIIA and IIIB polymorphisms with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 2003;61: 374-383.
Hikami K, Tsuchiya N*, Yabe T, Tokunaga K. Variations of human killer cell lectin-like receptors: common occurrence of NKG2-C deletion in the general population. Genes Immun 2003;4:160-167.
Hiroi Y*, Nakao T, Tsuchiya N, Takeda N, Maemira K, Nakamura F, Ohno M, Hirata Y, Nagai R. Excerbation of Lambert-Eaton myasthenic syndrome caused by an L-type Ca2+ channel antagonist. Jpn Heart J 2003;44:139-144.
Sekiya T, Tsunemi Y, Miyamasu M, Ohta K, Morita A, Saeki H, Matsushima K. Yoshie O, Tsuchiya N, Yamaguchi M, Yamamoto K, Tamaki K, Hirai K*. Variations in the human Th2-specific chemokine TARC gene. Immunogenetics 2003;54: 742-745.
Kyogoku C, Tsuchiya N*, Shibue T, Tokunaga K, Matsuta K. TNFR2 position 196 polymorphism in Japanese patients with rheumatoid arthritis: comment on the article by Dieudé et al [letter]. Arthritis Rheum 2003;48: 273-274.
Kyogoku C, Tsuchiya N*, Matsuta K, Tokunaga K. Studies on the association of Fcg receptor IIA, IIB, IIIA and IIIB polymorphisms with rheumatoid arthritis in Japanese: Evidence for a genetic interaction between HLA-DRB1 and FCGR3A. Genes Immun 2002;3: 488-493.
Sato M, Ohashi J, Tsuchiya N, Kashiwase K, Ishikawa Y, Arita H, Hanaoka K, Tokunaga K, Yabe T*. Association of HLA-A*3303-B*4403-DRB1*1302 haplotype, but not of TNFα promoter and NKp30 polymorphism, with postherpetic neuralgia (PHN) in the Japanese population. Genes Immun 2002;3: 477-481.
Kawasaki A, Tsuchiya N*, Fukazawa T, Hashimoto H, Tokunaga K. Analysis on the association of human BLYS (BAFF, TNFSF13B) polymorphisms with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun 2002;3: 424-429.
Kuroki K, Tsuchiya N*, Tsao BP, Grossman JM, Fukazawa T, Hagiwara K, Kano H, Takazoe M, Iwata T, Hashimoto H, Tokunaga K. Polymorphisms of human CD19 gene: Possible association with susceptibility to systemic lupus erythematosus in Japanese. Genes Immun 2002;3 Suppl 1:S21-30.
Kyogoku C, Dijstelbloem HM, Tsuchiya N*, Hatta Y, Kato H, Yamaguchi A, Fukazawa T, Jansen MD, Hashimoto H, van de Winkel JGJ, Kallenberg CGM, Tokunaga K. Fcg receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: Contribution of FCGR2B to genetic susceptibility. Arthritis Rheum 2002;46: 1242-1254.
Sirikong M, Tsuchiya N*, Chandanayingyong D, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Siriboonrit U, Tokunaga K. Association of HLA-DRB1*1502-DQB1*0501 haplotype with susceptibility to systemic lupus erythematosus in Thais. Tissue Antigens 2002;59: 113-117.
Sato M, Ohashi J, Tsuchiya N, Tadokoro K, Juji T, Hanaoka K, Tokunaga K, Yabe T*. Identification of novel single nucleotide substitutions in the NKp30 gene expressed in human natural killer cells. Tissue Antigens 2001;58: 255-258.
Miyamasu M, Sekiya T, Ohta K, Ra C, Yoshie O, Yamamoto K, Tsuchiya N, Tokunaga K, Hirai K*.Variations in the human CC chemokine eotaxin gene. Genes Immun 2001;2: 461-463.
Tsuchiya N*, Kawasaki A, Tsao BP, Komata T, Grossman JM, Tokunaga K. Analysis of the association of HLA-DRB1, TNFa promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium test. Genes Immun 2001;2:317-322. (The first two authors contributed equally to this work.)
Kawasaki A, Tsuchiya N*, Fukazawa T, Hashimoto H, Tokunaga K. Presence of four major haplotypes in human BCMA gene: Lack of association with systemic lupus erythematosus and rheumatoid arthritis. Genes Immun2001; 2: 276-279.
Sakurai D, Yamaguchi A, Tsuchiya N*, Yamamoto K, Tokunaga K. Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Biochem Biophys Res Commun 2001;284: 436-442.
Hagiwara K, Yamaguchi A, Tsuchiya N*, Kitamura S, Iwadare J, Sahara R, Yamamoto K, Tokunaga K. Identification of genes differentially expressed in the inflamed colonic lesions of Crohn’s disease. Biochem Biophys Res Commun 2001;283: 130-135.
Wakui M, Yamaguchi A, Sakurai D, Ogasawara K, Yokochi T, Tsuchiya N, Ikeda Y, Tokunaga K*. Genes highly expressed in the early phase of murine graft-versus-host reaction. Biochem Biophys Res Commun 2001;282: 200-206.
Mitsui H, Tsuchiya N, Okinaga S, Matsuta K, Yoshimura K, Nishimura A*. Expression of membrane-type metalloproteinases in synovial tissue from patients with rheumatoid arthritis or osteoarthritis. Mod Rheumatol 2001;11: 34-39.
Ohashi J*, Yamamoto S, Tsuchiya N, Hatta Y, Komata T, Matsushita M, Tokunaga K. Comparison of statistical power between 2 x 2 allele frequency and allele positivity tables in case-control studies of complex disease genes. Ann Hum Genet 2001;65:197-206.
Hikami K, Tsuchiya N*, Tokunaga K. New variations in human OX40 ligand (CD134L) gene. Genes Immun 2000;1: 521-522.
Tsuchiya N*, Komata T, Matsushita M, Ohashi J, Tokunaga K. New single nucleotide polymorphisms in the coding region of human TNFR2. Genes Immun 2000;1: 501-503.
Matsushita M, Tsuchiya N*, Oka T, Yamane A, Tokunaga K: New polymorphisms of humanCD80 and CD86. Lack of association with rheumatoid arthritis and systemic lupus erythematosus. Genes Immun 2000;1:428-434.
Kawasaki A, Tsuchiya N*, Hagiwara K, Takazoe M, Tokunaga K: Independent contribution of HLA-DRB1 and TNFa promoter polymorphisms to the susceptibility to Crohn’s disease. Genes Immun 2000;1: 351-357.
Kato H, Tsuchiya N*, Tokunaga K. Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2, and CXCR3. Genes Immun 2000;1: 330-337.
Shibue T, Tsuchiya N*, Komata T, Matsushita M, Shiota M, Ohashi J, Wakui M, Matsuta K, Tokunaga K. Tumor necrosis factor-a 5’-flanking region, TNF receptor II and HLA-DRB1 polymorphisms in the Japanese patients with rheumatoid arthritis. Arthritis Rheum 2000;43: 753-757.
Hagiwara K, Tsuchiya N*, Takazoe M, Yamamoto K, Tokunaga K. Identification of the gene variations in human IKKa. Immunogenetics 1999;50: 363-365.
Matsushita M, Tsuchiya N*, Shiota M, Komata T, Matsuta K, Zama K, Oka T, Juji T, Yamane A, Tokunaga K. Lack of a strong association of CTLA-4 exon 1 polymorphism with the susceptibility to rheumatoid arthritis and systemic lupus erythematosus in Japanese: An association study using a novel variation screening method. Tissue Antigens 1999;54: 578-584.
Kato H, Tsuchiya N*, Izumi S, Miyamasu M, Nakajima T, Kawasaki H, Hirai K, Tokunaga K. New variations of human b-chemokine receptors CCR3 and CCR4. Genes Immun 1999;1: 97-104.
Matsushita M, Tsuchiya N*, Nakayama T, Ohashi J, Shibue T, Shiota M, Yamane A, Tokunaga K. Allele typing of human TNFA 5’-flanking region using PCR-PHFA (preferential homoduplex formation assay): linkage disequilibrium with HLA class I and class II in Japanese. Tissue Antigens 1999;54: 478-484.
Hatta Y, Tsuchiya N*, Ohashi J, Matsushita M, Fujiwara K, Hagiwara K, Juji T, Tokunaga K. Association of Fcg receptor IIIB, but not of Fcg receptor IIA and IIIA, polymorphisms with systemic lupus erythematosus in Japanese. Genes Immun 1999;1: 53-60.
Konno Y*, Numaga J, Tsuchiya N, Ogawa A, Islam SMM, Mochizuki M, Mitsui H, Oda H, Maeda H. HLA-B27 subtypes and HLA class II alleles in Japanese patients with anterior uveitis. Invest Ophthal Vis Sci 1999;40: 1838-1844.
Komata T, Tsuchiya N*, Matsushita M, Hagiwara K, Tokunaga K. Association of tumor necrosis factor receptor 2 (TNFR2) polymorphism with susceptibility to systemic lupus erythematosus. Tissue Antigens 1999;53:527-533.
Komatsu-Wakui M, Tokunaga K*, Ishikawa Y, Kashiwase K, Moriyama S, Tsuchiya N, Ando H, Shiina T, Geraghty DE, Inoko H, Juji T. MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype. Immunogenetics 1999;49: 620-628.
Matsushita M, Tsuchiya N*, Oka T, Yamane A, Tokunaga K. New variations of human SHP-1. Immunogenetics 1999;49: 577-579.
Komata T, Tsuchiya N*, Hatta Y, Matsushita M, Ogawa A, Mitsui H, Tokunaga K: HLA-DRB1 alleles encoding the shared epitope associated with rheumatoid arthritis confer additional susceptibility to seronegative spondyloarthropathies in HLA-B27 positive Japanese individuals. Jpn J Rheumatol 1999;9: 55-64.
Hatta Y, Tsuchiya N*, Matsushita M, Shiota M, Hagiwara K, Tokunaga K. Identification of the gene variations in human CD22. Immunogenetics 1999;49: 280-286.
Sakata Y*, Tokunaga K, Yonehara Y, Bannai M, Tsuchiya N, Susami T, Takato T. Significant association of HLA-B and HLA-DRB1 alleles with cleft lip with or without cleft palate. Tissue Antigens 1999;53:147-152.
Sobao Y, Tsuchiya N*, Takiguchi M, Tokunaga K. Overlapping peptide-binding specificities of HLA-B27 and B39. Evidence for a role of peptide supermotif in the pathogenesis of spondylarthropathies. Arthritis Rheum 1999; 42: 175-181. (The first two authors contributed equally.)
Suzuki T*, Mato T, Tsuchiya N, Honda Z, Yamamoto K. Enlargement of multiple cavernous hemangioma of the liver in patients with systemic lupus erythematosus: a report of four cases. Jpn J Rheumatol 1998;8:445-452.
Furuya T*, Hakoda M, Higami K, Ueda H, Tsuchiya N, Tokunaga K, Kamatani N, Kashiwazaki S. Association of HLA class I and class II alleles with myositis in Japanese patients. J Rheumatol 1998;25:1109-1114.
Tsuchiya N*, Shiota M, Moriyama S, Ogawa A, Komatsu-Wakui M, Mitsui H, Geraghty DE, Tokunaga K. MICA allele typing of HLA-B27 positive Japanese patients with seronegative spondylarthropathies and healthy individuals. Differential linkage disequilibrium with HLA-B27 subtypes. Arthritis Rheum 1998;41: 68-73.
Suzuki T*, Tsuchiya N, Ito K. Multiple cavernous hemangiomas of the liver in patients with systemic lupus erythematosus [letter]. J Rheumatol 1997;24: 810.
Huang F, Yamaguchi A, Tsuchiya N, Ikawa T, Tamura N, Virtala MMK, Granfors K, Yasaei P, Yu DTY*. Induction of alternative splicing of HLA-B27 by bacterial invasion. Arthritis Rheum 1997:40: 694-703.
Yamaguchi A, Tsuchiya N*, Shiota M, Ito K, Yoshinoya S, Tokunaga K, Mitsui H, Ogawa A, Juji T. HLA-B associations of HLA-B27 negative ankylosing spondylitis: Reply [letter]. Arthritis Rheum 1996;39:1769.
Yamaguchi A, Ogawa A, Tsuchiya N*, Shiota M, Mitsui H, Tokunaga K, Tadokoro K, Juji T, Ito K. HLA-B27 subtypes in Japanese with seronegative spondyloarthropathies and healthy controls. J Rheumatol 1996;23:1189-1193.
Tsuchiya N*, Shiota M, Yamaguchi A, Ito K. Elevated serum level of soluble HLA-class I antigens in patients with systemic lupus erythematosus. Arthritis Rheum 1996;39: 792-796.
Yamaguchi A, Tsuchiya N*, Mitsui H, Shiota M, Ogawa A, Tokunaga K, Yoshinoya S, Juji T, Ito K. Association of HLA-B39 with HLA-B27-negative ankylosing spondylitis and pauciarticular juvenile rheumatoid arthritis in Japanese patients. Evidence for a role of the peptide-anchoring B pocket. Arthritis Rheum 1995;38:1672-1677.
Johansson PJH*, Ota T, Tsuchiya N, Malone CC, Williams RCJr. Studies of protein A and herpes simplex virus-1 induced Fcg - binding specificities. Different binding patterns for IgG3 from Caucasian and Oriental subjects. Immunology 1994;83: 631-638.
Murayama T*, Tsuchiya N, Jisaki F, Ozaki M, Sakamuro D, Hirai K, Shimizu S, Ito K, Matsushima K, Furukawa T. Elevated cytokine levels in the synovial fluid of rheumatoid arthritis correlate with the presence of cytomegalovirus DNA. Autoimmunity 1994;17: 333-337.
Tsuchiya N*, Endo T, Shiota M, Kochibe N, Ito K, Kobata A: Distribution of glycosylation abnormality in serum IgG subclasses from patients with rheumatoid arthritis. Clin Immunol Immunopathol 1994;70: 47-50.
Tsuchiya N*, Sato M, Uesaka Y, Kurose N, Haida M, Nakano J, Tsuchida T, Inoue T, Ito K: Lambert-Eaton myasthenic syndrome associated with Sjögren syndrome. Scand J Rheumatol 1993;22: 302-304.
Tsuchiya N*, Murayama T, Yoshinoya S, Matsuta K, Shiota M, Furukawa T, Ito K. Antibodies to human cytomegalovirus 65-kilodalton Fc binding protein in rheumatoid arthritis : idiotypic mimicry hypothesis of rheumatoid factor production. Autoimmunity 1993;15: 39-48.
Tsuchiya N*, Endo T, Matsuta K, Yoshinoya S, Takeuchi F, Nagano Y, Shiota M, Furukawa K, Kochibe N, Ito K, Kobata A. Detection of glycosylation abnormality in rheumatoid IgG using N-acetylglucosamine-specific Psathyrella velutina lectin (PVL). J Immunol 1993;151:1137-1146.
Williams RCJr*, Kievit E, Tsuchiya N, Malone C, Hutt-Fletcher LM. Differential peptide mapping of Fcg-binding and monoclonal-antibody-reactive epitopes on gE, the Fcg-binding glycoprotein of Herpes Simplex Virus type 1. J Immunol 1992;149: 2415-2427.
Williams RCJr*, Malone CC, Tsuchiya N. Rheumatoid factors from patients with rheumatoid arthritis react with b2-microglobulin. J Immunol 1992;149: 1104-1113.
Murayama T*, Jisaki F, Ayata M, Sakamuro D, Hironaka T, Hirai K, Furukawa T, Tsuchiya N, Ito K. Cytomegalovirus genomes demonstrated by polymerase chain reaction in synovial fluid from rheumatoid arthritis patients. Clin Exp Rheumatol 1992;10: 161-164.
Zhang XY, Tsuchiya N*, Dohi M, Yamamoto K, Ishihara K, Okudaira H, Ito K, Miyamoto T. Prolonged survival of MRL-lpr/lpr mice treated with Tripterygium Wilfordii Hook-F. Clin Immunol Immunopathol 1992;62:66-71.
Tsuchiya N, Malone C, Hutt-Fletcher LM, Williams RCJr*. Rheumatoid factors react with Fab fragments of monoclonal antibodies to Herpes Simplex Virus types 1 and 2 Fcg-binding proteins. Arthritis Rheum 1991;34: 846-855.
Tsuchiya N, Husby G, Williams RCJr*. Antibodies to the peptide from the plasmid-coded Yersinia outer membrane protein (YOP1) in patients with ankylosing spondylitis. Clin Exp Immunol1990;82:493-498.
Tsuchiya N, Husby G, Williams RCJr*, Stieglitz H, Lipsky PE, Inman RD. Autoantibodies to HLA-B27 sequence cross-react with the hypothetical sequence of arthritis-associated Shigella plasmid. J Clin Invest1990;86: 1193-1203.
Tsuchiya N, Williams RCJr*, Hutt-Fletcher LM. Rheumatoid factors may bear the internal image of the Fcg-binding protein of herpes simplex virus type 1. J Immunol 1990;144: 4742-4748.
Tsuchiya N*, Husby G, Williams RCJr. Studies of humoral and cell-mediated immunity to peptides shared by HLA-B27.1 and Klebsiella pneumoniae nitrogenase in ankylosing spondylitis. Clin Exp Immunol1989;76: 354-360.
Husby G, Tsuchiya N, Schwimmbeck PL, Keat A, Pahle JA, Oldstone MBA, Williams RCJr*. Cross-reactive epitope with Klebsiella pneumoniae nitrogenase in articular tissue of HLA-B27+ patients with ankylosing spondylitis. Arthritis Rheum 1989;32:437-445.
Tsuchiya N*, Endo T, Matsuta K, Yoshinoya S, Aikawa T, Kosuge E, Takeuchi F, Miyamoto T, Kobata A: Effects of galactose depletion from oligosaccharide chains on immunological activities of human IgG. J Rheumatol 1989;16: 285-290.
Husby G, Tsuchiya N, Schwimmbeck PL, Keat A, Pahle JA, Oldstone MBA, Williams RCJr*. Synovial expression of HLA-B27 related antigens in ankylosing spondylitis. Scand J Rheumatol 1988;76(Suppl): 23-25.
Tsuchiya N*, Mitamura T, Goto M, Moroi Y, Kinoshita M, Yokohari R, Miyamoto T. 2-dimensional flow cytometric analysis of peripheral Blood T lymphocytes from patients with systemic lupus erythematosus. Preferential expression of HLA-DR antigen on the surface of Leu 2a+ cells. J Rheumatol 1988;15:946-951.
Tsuchiya N*, Hirohata S, Iwamoto S, Miyamoto T. Serum cholinesterase activity in patients with systemic lupus erythematosus. Jpn J Rheumatol 1986;1:105-111.

英文総説その他

Kawasaki A, Tsuchiya N*. Advances in the genomics of ANCA-associated vasculitis—a view from East Asia. Genes Immun 2021 Mar 8. doi: 10.1038/s41435-021-00123-x. Online ahead of print
Tsuchiya N*, Kawasaki A. HLA-DRB1 and FCGR2B: highlights of the first genome-wide association study of IgG4-related disease. Lancet Rheumatol Published online: August 06, 2019. doi: https://doi.org/10.1016/S2665-9913(19)30015-3
Furukawa H*, Oka S, Tsuchiya N, Shimada K, Hashimoto A, Tohma S, Kawasaki A.The role of common protective alleles HLA-DRB1*13 among systemic autoimmune diseases" Genes Immun 2016 Nov 10. doi: 10.1038/gene.2016.40.
Tsuchiya N*, Ohashi J. Editorial: Human immune system diversity and its implications in diseases. J Hum Genet 60: 655-656; doi:10.1038/jhg.2015.101
Tsuchiya N*. Genetics of ANCA-associated vasculitis in Japan - a role for HLA-DRB1*09:01 haplotype. Clin Exp Nephrol　2013; 17:628-630. doi 10.1007/s10157-012-0691-6.
Tsuchiya N*. Genetics of microscopic polyangiitis in the Japanese population. Ann Vasc Dis　2012;5(3):289-295.
Tsuchiya N*, Kawasaki A, Ito I. Role of IRF5, STAT4 and BLK polymorphisms for the genetic predisposition to systemic lupus erythematosus in Japanese. Inflammation Regenerat 2009;29:190-197.
Kyogoku C, Tsuchiya N*. A compass that points to lupus: Genetic studies on type I interferon pathway. Genes Immun 2007;8:445-455.
Tsuchiya N*, Kyogoku C, Miyashita R, Kuroki K. Diversity of human immune system multigene families and its implication in the genetic background of rheumatic diseases. Curr Med Chem 2007;14:421-439.
Tsuchiya N, Ohashi J, Tokunaga K*. Variations in immune response genes and their associations with multifactorial immune disorders. Immunol Rev 2002;190:169-181.
Tsuchiya N*, Honda Z, Tokunaga K. Role of B cell inhibitory receptor polymorphisms for systemic lupus erythematosus: a negative times a negative makes a positive. J Hum Genet 2006;51:741-750.
Tsuchiya N*, Kyogoku C. Role of Fcg receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: Insights from Asia. Autoimmunity 2005;38:347-352.

Tsuchiya N

Clin Orthop Relat R

Tsuchiya N, Williams RCJr*. Possible relationship between bacterial or viral Fcg binding proteins and rheumatoid factor. Immunomethods1993;2:65-70.
Tsuchiya N*, Williams RCJr. Molecular mimicry - Hypothesis or reality? West J Med 1992;157: 133-138.
Williams RCJr*, Tsuchiya N, Husby G. Molecular mimicry, ankylosing spondylitis and reactive arthritis - something missing ? Scand J Rheumatol 1992;21:105-108.

英文著書（共著）

Tsuchiya N*. Genetics. In: Hirohata S. (eds) Neuropsychiatric Systemic Lupus Erythematosus. Springer, Cham, 2018, pp.15-27, https://doi.org/10.1007/978-3-319-76496-2_2
Tsuchiya N*, Kawasaki A. Genetics of Systemic Sclerosis. In:In: Takehara K, Kuwana M, Fujimoto M. (eds) Systemic Sclerosis. Springer, Tokyo, 2016, pp81-92, doi10.1007/978-4-431-55708-1_5
Tsuchiya N*, Endo T, Kochibe N, Ito K, Kobata A. Use of lectin to detect agalactosyl IgG. Use of lectin to detect agalactosyl IgG. In: Rhodes JM, Milton JD. (eds) Methods in Molecular Medicine, Lectin Methods and Protocols. Humana Press, Totowa, NJ, 1997, pp195-205.

和文原著

松多邦雄、土屋尚之、竹内二士夫、森正樹、中野啓一郎：慢性関節リウマチに対するロベンザリット２ナトリウム(CCA)と防已黄耆湯併用による臨床効果と安全性に関する検討。リウマチ科 1995;14:169-176.
相馬良直、石橋康正、土屋尚之、谷憲三朗、浅野茂隆：Neutrophilic dermatosis of myeloproliferative disorders. Myelodysplastic syndromeに伴う特異な紅斑の一例。皮膚科の臨床 1993;35:1457-1460.
村山次哉、地崎赴美子、綾田稔、土屋尚之、伊藤幸治、平井莞二、弘中孝史、古川宣：慢性関節リウマチ患者関節液からのヒトサイトメガロウイルスDNAの検出。医学のあゆみ 1991;158: 171-172.

和文著書（共著）

土屋尚之. 病因 1. 遺伝的素因. 『ANCA関連血管炎診療ガイドライン2023』（厚生労働科学研究費補助金難治性疾患政策研究事業　針谷正祥、成田一衛、須田隆文編集）診断と治療社、東京、pp97-102, 2023.
土屋尚之：第2章 13.全身性エリテマトーデス、全身性強皮症、ANCA関連血管炎. 遺伝子医学MOOK別冊『シリーズ：最新遺伝医学研究と遺伝カウンセリング　シリーズ３「最新多因子遺伝性疾患研究と遺伝カウンセリング」』（櫻井晃洋　編）メディカル　ドゥ、大阪、pp174-183, 2018.
土屋尚之: B　血管炎、2　感受性遺伝子. 『臨床脈管学』（重松宏　編集）日本医学出版、東京、pp21-23, 2017.
川﨑綾, 土屋尚之: II.病因、1遺伝的素因. 『ANCA関連血管炎診療ガイドライン2017』（厚生労働科学研究費補助金難治性疾患等政策研究事業（難治性疾患政策研究事業）有村義宏、丸山彰一、本間栄　編集）診断と治療社、東京、pp.61-64,2017.
土屋尚之：ヒトゲノム解析からみた全身性エリテマトーデスの病因. 『最新医学別冊診断と治療のABC　118　全身性エリテマトーデス』（田中良哉企画）pp32-43, 2016.
八谷有紀、古川宏、土屋尚之：遺伝因子。『強皮症の基礎と臨床』（佐藤伸一編）医薬ジャーナル社、大阪、pp60-69、2016.
土屋尚之：環境因子と遺伝因子（「ANCA関連血管炎の診療ガイドライン」尾崎承一、槇野博史、松尾清一編）厚生労働省　難治性疾患克服研究事業、pp10-11, 2011.
土屋尚之：全身性強皮症の疾患感受性遺伝子にはどのようなものがあるか。皮膚科臨床アセット7「皮膚科膠原病のすべて」（古江増隆、佐藤伸一編）中山書店、東京、pp.161-165, 2011
土屋尚之：全身性エリテマトーデスの疾患感受性遺伝子にはどのようなものがあるか。皮膚科臨床アセット7「皮膚科膠原病のすべて」（古江増隆、佐藤伸一編）中山書店、東京、pp.63-67, 2011
土屋尚之：病因。最新医学別冊「新しい診断と治療のABC 67 全身性エリテマトーデス」（竹内勤編）最新医学社 pp.58-71,2010.
土屋尚之：病因：(1)遺伝。最新医学別冊「新しい診断と治療のABC 31 ANCA関連腎炎」（長澤俊彦編）最新医学社 pp.46-54,2005.
土屋尚之：SLEおよびSLEモデルマウスにおける疾患感受性遺伝子解析。リウマチ・膠原病最新トピックス　変わりゆく研究と診療（竹原和彦、佐藤伸一、桑名正隆編）診断と治療社, pp.34-37, 2005.
土屋尚之：強直性脊椎炎。リウマチ基本テキスト（第２班）日本リウマチ財団教育研修委員会, pp374-377, 2005.
土屋尚之：免疫疾患の疾患感受性遺伝子。シミュレイション内科「リウマチ・アレルギー疾患を探る」（山本一彦編）　永井書店, pp7-10, 2005.
土屋尚之：血清反応陰性脊椎関節症の発症機序。NEW MOOK 整形外科14「リウマチ類縁疾患」（越智隆弘、菊池臣一編）金原出版, pp82-86, 2004.
土屋尚之：血清反応陰性脊椎関節症。内科学（第２版）（黒川　清、松澤佑次編集主幹）文光堂, pp2197-2198, 2003.
土屋尚之：血清反応陰性脊椎関節症。喘息・アレルギー・リウマチ治療薬ハンドブック（伊賀立二、森田寛、永倉俊和、廣畑俊成編集）メディカルレビュー社, pp106-113, 2003.
土屋尚之：Seronegative spondyloarthropathy. 目でみる関節疾患（東京大学整形外科　関節診編著）マルホ, pp18-19, 2002.
土屋尚之：強直性脊椎炎。リウマチ基本テキスト。日本リウマチ財団教育研修委員会, pp360-363, 2002.
土屋尚之、徳永勝士：血管炎と疾患感受性遺伝子。血管炎（長澤俊彦監修、橋本博史編集）朝倉書店, pp13-18, 2001.
土屋尚之：血清反応陰性脊椎関節症。内科学（黒川　清、松澤佑次編集主幹）文光堂, pp.2095-2097, 1999.
土屋尚之：免疫遺伝学(HLA)。リウマチ教育研修会テキスト（第四版）（吉野槇一、山本純己監修）。日本リウマチ財団教育研修委員会, pp17-25, 1999.
土屋尚之：強直性脊椎炎。疾患別最新処方（矢崎義雄、戸田剛太郎監修）（第３版）。メジカルビュー社, pp570-171, 1998.
土屋尚之：乾癬性関節炎。疾患別最新処方（矢崎義雄、戸田剛太郎監修）（第３版）。メジカルビュー社, pp568-569, 1998.
土屋尚之、伊藤幸治:リウマトイド因子。分子細胞生物学辞典。東京化学同人, p838, 1997.
土屋尚之、伊藤幸治: 慢性関節リウマチ。分子細胞生物学辞典。東京化学同人, p779, 1997.
土屋尚之：リウマチ性多発筋痛症・びまん性好酸球性筋膜炎。臨床検査・診断指針（大久保昭行、松枝啓、吉野谷定美、井上博、北村聖編）。南江堂, pp759-760, 1996.
土屋尚之：強直性脊椎炎、ライター症候群。臨床検査・診断指針（大久保昭行、松枝啓、吉野谷定美、井上博、北村聖編）。南江堂, pp761-763, 1996.
土屋尚之：リウマチ性多発筋痛症。疾患別最新処方（矢崎義雄、戸田剛太郎監修）（第２版）。メジカルビュー社, pp544-545, 1995.
土屋尚之：慢性関節リウマチの環境要因（感染）。慢性関節リウマチ　最新の知見（柏崎禎夫、松井宣夫編）ミドリ十字, pp13-15, 1994。
土屋尚之：内科的治療。リウマチ（森藤忠夫・松多邦雄編）有斐閣, 1993.
土屋尚之：IV型アレルギー反応と病態。臨床アレルギー学（宮本昭正監修）。南江堂, pp139-145, 1992.
土屋尚之：慢性関節リウマチ。疾患別最新処方（上田泰、清水喜八郎、春美建一編集）。メジカルビュー社, pp520-523, 1992。
土屋尚之：Eosinophilia-myalgia syndrome.　医科学大事典 suppl. 9 最新の医療情報 1992 （岡　博、和田　攻編）講談社, pp31-32, 1991.
土屋尚之：治療に必要な病態生理の基礎知識。VII.免疫・アレルギー。最新看護学ー疾患編３　治療学。（釘宮豊城、田上恵編集）真興交易医書出版部, pp45-49, 1991.

特集企画

土屋尚之：「免疫系多重遺伝子ファミリー多様性と疾患」炎症と免疫 2022;30(5)
土屋尚之：「ANCA関連血管炎の病因研究」炎症と免疫 2020;28(4)
土屋尚之：「リウマチ・膠原病におけるHLA研究の進展」炎症と免疫 2018;26(6)
Tsuchiya N, Ohashi J(guest editors). Special Section: Human immune system diversity and its implications in diseases. J Hum Genet 60: 655-656; doi:10.1038/jhg.2015.101
土屋尚之：「HLAのブレイクスルー-臨床応用と疾患研究の進歩」医学のあゆみ 2014;251(4)
土屋尚之：「リウマチ・膠原病のゲノム解析update」炎症と免疫 2013;21(5)

和文総説・解説

土屋尚之: 序（特集「免疫系多重遺伝子ファミリー多様性と疾患」）炎症と免疫 2022;30(5),389.
土屋尚之、川﨑綾: ANCA関連血管炎の遺伝要因。日本臨床 2022; 80(8): 1196-1202.
土屋尚之：全身性強皮症の疾患感受性遺伝子。皮膚科 2022; 1(5): 586-593.
土屋尚之、川﨑綾： ANCA関連血管炎の遺伝的背景-日本人集団における知見。臨床免疫・アレルギー科 2021; 76(4): 377-385.
土屋尚之、川﨑綾: ANCA関連血管炎のゲノム解析。腎と透析 2021; 91(3): 439-443.
土屋尚之：序（特集「ANCA関連血管炎の病因研究」）炎症と免疫 2020;28(4),261.
土屋尚之、横山望：全身性エリテマトーデス-ゲノム解析から推測される発症関連分子経路-。 2019; 72,363-371.
土屋尚之：序（特集「リウマチ・膠原病におけるHLA研究の進展」）炎症と免疫 2018;26(6),465-466.
土屋尚之：多発血管炎性肉芽腫症ー疫学・遺伝疫学. 日本臨床（増刊号：血管炎[第２版]）2018; 76(Suppl.6), 238-244.
樋口貴士, 土屋尚之. 自己免疫疾患とGWAS. 腎臓内科・泌尿器科 2017;5(1):44-48.
川崎綾、土屋尚之：全身性エリテマトーデスの病因-ゲノム解析からの知見。医学のあゆみ 2016; 258(10):932-937.
土屋尚之：膠原病および類縁疾患のゲノム解析の現況～GWASおよびpost GWAS～. リウマチ科 2015;54(4),473-479.
土屋尚之、川崎綾、岡笑美、古川宏：リウマチ・膠原病とHLA. MHC 2015;22(2),74-83.
土屋尚之：全身性強皮症の疾患感受性遺伝子解析. 医学のあゆみ 2014;251(8)614-619.
土屋尚之：はじめに（特集「HLAのブレイクスルー-臨床応用と疾患研究の進歩」）医学のあゆみ 2014;251(4),265.
土屋尚之：ANCA関連血管炎の集団差とHLA.分子リウマチ治療 2014;7,103-106.
土屋尚之：関節リウマチの病因研究:概論. 日本臨床 2014;72(Suppl.3),35-39.
土屋尚之：RAにおけるグランザイムB遺伝子(GZMB)多型と関節破壊進行度との関連. リウマチ科 2014;51(1),89-92.
土屋尚之：SLEの疾患感受性遺伝子研究2013. リウマチ科 2013;50(5), 517-524.
土屋尚之：序（特集｢リウマチ・膠原病のゲノム解析update」）炎症と免疫 2013;21(5), 371-372.
土屋尚之：GPAとMPAの遺伝学的相違. リウマチ科 2013;49(5), 611-615.
土屋尚之：HLA～still alive and well. アレルギー・免疫 2013;20(6), 821-822.
土屋尚之：ANCA関連血管炎疾患感受性遺伝子.日本臨床 2013;71(suppl 1), 208-213.
土屋尚之：全身性エリテマトーデスの疾患感受性遺伝子. 腎と透析 2013;74(1)15-20.
土屋尚之: ANCA関連血管炎の遺伝因子. 感染・炎症・免疫 2012;42(4),345-348.
土屋尚之：総論～膠原病疾患感受性遺伝子解析の視点から～. BIO Clinica 2012;27:1020-1022.
土屋尚之:次世代シークエンサーを用いた、日本人集団における膠原病疾患感受性遺伝子の包括的同定（第1回真鍋奨学助成受賞論文）。アレルギア 2011;40:105-108.
土屋尚之: ANCA関連血管炎の遺伝因子。リウマチ科 2011;46:421-426.
土屋尚之：関節リウマチにおける疾患抵抗性HLA-DRB1アリル。リウマチ科 2011;45:62-67.
土屋尚之：膠原病のゲノム解析。カレントテラピー 2010;28:884-890.
土屋尚之：膠原病の疾患感受性遺伝子解析. 臨床と研究 2010;87:1184-1189.
土屋尚之：ゲノミクスによる血管炎関連遺伝子の探索。炎症と免疫 2010;18:502-508.
土屋尚之、伊東郁恵、川崎綾：IRF5, STAT4, BLKと全身性エリテマトーデスをはじめとする膠原病との関連。日本臨床免疫学会誌 2010;33:57-65.
土屋尚之：遺伝子解析からみた全身性エリテマトーデス個別化医療の可能性。リウマチ科 2010;43:166-170.
土屋尚之：環境因子(日本臨床増刊号「関節リウマチ（第２版）」) 日本臨床 2010;68(suppl. 5):80-84.
土屋尚之：全身性エリテマトーデスの疾患関連遺伝子。炎症と免疫 2009;17:507-514.
土屋尚之：全身性エリテマトーデス疾患感受性遺伝子研究の現況。医学のあゆみ 2009;230:591-598.
土屋尚之：日本人集団における顕微鏡的多発血管炎の疾患感受性遺伝子解析。脈管学 2009;49:31-37.
土屋尚之：多因子疾患におけるヒトゲノム解析研究の意義。アレルギーの臨床 2009;29:203-208.
土屋尚之: 日本人におけるループス腎炎と遺伝子多型。リウマチ科 2008:40:583-588.
土屋尚之: 関節リウマチとHLA。MHC 2008;15:235-248.
土屋尚之: 関節リウマチ、全身性エリテマトーデスとSTAT4遺伝子。Frontiers in Rheumatology & Clinical Immunology 2008;2:146-149.
土屋尚之：SLEの遺伝素因-最近の研究の進歩。最新医学 2008;63: 896-903.
土屋尚之: 全身性エリテマトーデス-疾患感受性遺伝子探索の最近の進歩-。リウマチ科 2007;37:203-208.
京極千恵子、土屋尚之：全身性エリテマトーデスにおけるIRF5多型の意義。医学のあゆみ 2007;222:214-216.
土屋尚之：関節リウマチ関連遺伝子解析に基づく新規治療法開発の可能性。BIO Clinica 2007;22:894-897.
土屋尚之、京極千恵子: SLE発症の分子機序-ゲノム解析による最新の知見。リウマチ科 2007;38:103-108.
櫻井大祐、川﨑　綾、小端哲二、土屋尚之：BAFF, APRILの機能と自己免疫疾患における役割。分子リウマチ 2007;4:307-313.
土屋尚之: 強直性脊椎炎の発症にかかわる遺伝因子。リウマチ科 2007;38:409-415.
土屋尚之、宮下リサ：顕微鏡的多発血管炎の疾患感受性とKIR-HLA遺伝子相互作用。リウマチ科 2006;36:514-521.
土屋尚之：関節リウマチ重症度と関連する免疫系機能遺伝子多型。リウマチ科 2006;36:294-298.
土屋尚之： TOPICS: TNF阻害薬抵抗性の関節リウマチに対するabatacept（CTLA4-Ig）の有効性。内科 2006;97:735-737.
土屋尚之、本田善一郎：目で見るバイオサイエンス：全身性エリテマトーデスに見られる遺伝子多型。内科 2005;96:1115-1119.
土屋尚之：多因子遺伝病としてのリウマチアレルギー疾患：全身性エリテマトーデス。最新医学 2005;60（９月増刊号）：2120-2130.
土屋尚之：ANCA関連血管炎疾患感受性遺伝子解析の現状。医学のあゆみ 2005;214:63-66.
土屋尚之：自己免疫疾患の疾患感受性遺伝子-最近の話題-。最新医学 2005;60（６月増刊号）:1357-1365.
土屋尚之：RA関連遺伝子解析の最近のトピックス。Medical Practice 2005 ;22: 445-447.
申栄吉、土屋尚之：BAFF(BLyS)とその受容体の生理的役割と病態との関連。臨床免疫 2005;43:47-54.
土屋尚之：候補遺伝子アプローチによる解析。ゲノム医学 2005;5: 39-44.
土屋尚之：疾患感受性遺伝子検索の現状。（増刊号「関節リウマチ」）日本臨床 2005;63 Suppl 1: 111-116.
土屋尚之、京極千恵子：SLE疾患感受性とFcg受容体IIb多型の関連。臨床免疫 2004;42:435-441.
土屋尚之：関節リウマチの環境要因。医学のあゆみ 2004;209: 760-764.
土屋尚之：ゲノム解析によるリウマチ性疾患の病因・病態解明へのアプローチ。日本臨床免疫学会誌 2003;26: 103-114.
土屋尚之：SLEの疾患感受性遺伝子解析。臨床リウマチ 2003;15: 87-101.
土屋尚之：特集・BLySなどのＢ細胞刺激因子と自己免疫疾患・序　炎症と免疫 2003;11:383-384.
土屋尚之：BLyS. Surgery Frontier 2003;10: 59-62.
土屋尚之：リウマチ・膠原病におけるゲノム解析。Medical Practice 2003;20:650-651.
土屋尚之：ANCA関連血管炎の疾患感受性遺伝子。リウマチ科 2003;29:237-242.
土屋尚之：リウマチ性疾患の遺伝疫学。現代医療 2003;35:111-119.
平井浩一、関谷剛、土屋尚之：ケモカイン、ケモカイン受容体の遺伝子多型とその機能-CCR3, CCR4を中心に。アレルギー科 2002;14:408-414.
川崎　綾、土屋尚之：BLySとリウマチ性疾患。医学のあゆみ 2002;203:481-484.
土屋尚之：血清反応陰性脊椎関節症とHLA。リウマチ科 2002;28:295-302.
土屋尚之：全身性エリテマトーデス、関節リウマチ疾患感受性遺伝子研究の現状。医学のあゆみ 2002;202: 815-820.
櫻井大祐、土屋尚之：RA疾患感受性遺伝子、増悪関連遺伝子研究の現状。The Bone 2002;16: 463-468.
黒木喜美子、土屋尚之：リウマチ・膠原病のゲノム解析。アレルギー・免疫 2002;9:997-1005.
大橋順、土屋尚之、徳永勝士：HLA遺伝子と人類遺伝学。分子細胞治療 2002;1:428-433.
櫻井大祐、土屋尚之：慢性関節リウマチ患者滑膜におけるID遺伝子群の発現。臨床免疫 2002;37:184-190.
京極千恵子、土屋尚之、徳永勝士：全身性エリテマトーデスとFcgレセプター遺伝子の関連。蛋白質核酸酵素 2001;46: 2337-2341.
土屋尚之：血管炎の遺伝子解析。リウマチ科 2001;26: 237-242.
氷上光輝、土屋尚之、徳永勝士：SLEの遺伝子解析。リウマチ科 2001;26: 231-236.
黒木喜美子、土屋尚之：慢性関節リウマチ、全身性エリテマトーデスの遺伝素因。リウマチ科 2001;26: 39-44.
土屋尚之：リウマトイド因子の構造と起源。臨床免疫 2001;36: 304-308.
櫻井大祐、土屋尚之、徳永勝士：リウマチ・膠原病の遺伝子診療に向けてー現状と展望—。医学のあゆみ 2001;197: 1094-1099.
土屋尚之：SNP-リウマチ研究者の視点から-。リウマチ科 2001;25: 43-49.
土屋尚之、徳永勝士：リウマチ性疾患と疾患感受性遺伝子。リウマチ科 2000;24: 411-416.
土屋尚之、徳永勝士：血管炎と疾患感受性遺伝子。最新医学 2000;55: 2616-2622.
土屋尚之：Fcg受容体多型と自己免疫疾患。最新医学 2000;55: 2322-2328.
土屋尚之：SLEの連鎖解析。炎症と免疫 2000;8: 498-504.
土屋尚之：遺伝子変異に基づく免疫異常。内科 2000;86: 233-237.
土屋尚之：SLEにおけるFcgR, TNFR2遺伝子多型の解析。臨床免疫 2000;33: 307-314.
土屋尚之、徳永勝士：多因子病：免疫疾患。現代医療 2000:32: 259-264.
土屋尚之：SLEの疾患感受性遺伝子。医学のあゆみ 1999;191: 916-922.
土屋尚之：血清反応陰性脊椎関節症。日内会誌 1999;88:1955-1960.
土屋尚之、徳永勝士：膠原病の遺伝子解析。日内会誌 1999;88: 1341-1348.
土屋尚之、徳永勝士：膠原病の感受性遺伝子解析。日本臨床 1999;57:323-328.
土屋尚之：アレルギー疾患の遺伝子解析。診断と治療 1999;87:221-225.
徳永勝士、土屋尚之：多因子病としての免疫疾患。第25回日本医学会総会会誌 1999; 第２巻、p240.
土屋尚之：強直性脊椎炎とreactive arthritis. Medicina 1998;35:1771-1773.
土屋尚之：リウマチ性疾患感受性遺伝子。リウマチ科 1998;20:65-70.
土屋尚之：HLAと疾患感受性。炎症と免疫 1997;5:684-691.
小林茂人、土屋尚之：HLA class I 抗原と疾患。日本臨床免疫学会誌 1996;19:657-659.
土屋尚之：血清反応陰性脊椎関節症。内科 1996;78: 260-264.
土屋尚之：HLA-B27と強直性脊椎炎。炎症と免疫 1996;4:394-400.
土屋尚之：薬剤誘発ループス。内科 1996;77:1289.
土屋尚之：IgG のグリコシル化と慢性関節リウマチ。炎症と免疫 1996;4:91-97.
土屋尚之：慢性関節リウマチとアミロイドーシス。Medicina 1995;32: 2464-2466.
土屋尚之：特集：慢性関節リウマチ　環境要因。Mebio 1995;12: 30-36.
土屋尚之: リウマチ性疾患とHLA. 日常診療と血液 1995; 5:1301-1307.
土屋尚之: 成人発症Still病。内科 1995;75:1313.
土屋尚之：慢性関節リウマチの遺伝とHLA。Modern Physician 1994;14:3-6.
土屋尚之、山口晃弘: IgGの糖鎖異常。臨床検査 1993;37:1263-1265.
土屋尚之：膠原病とHLA。Practitioners 1993;2: 971-973.
土屋尚之：リウマトイド因子産生における分子相同説(molecular mimicry theory)とIgG糖鎖異常説。Medical Practice 1993;10:1953-1955.
土屋尚之：疾患概念の紹介ー感染とHLA抗原。カレントテラピー 1993;11:439-442.
土屋尚之：慢性関節リウマチのIgG糖鎖異常。蛋白質核酸酵素 1992;37:1935-1939.
土屋尚之、三森明夫：RAと環境要因ー微生物感染との関連。医学のあゆみ 1992;161: 558-561.
土屋尚之: 細菌物質によるimmunomodulation. 臨床免疫 1991;23:1711-1718.
土屋尚之：リウマトイド因子の産生機序ー微生物Fcg結合蛋白の関与。臨床免疫 1991;23: 896-903.
土屋尚之：強直性脊椎炎におけるHLA-B27と微生物抗原の意義。臨床免疫 1991;23: 602-608.
土屋尚之：強直性脊椎炎とHLA。BIOmedica 1991;6: 258-262.
土屋尚之：リウマトイド因子の新知見ーリウマトイド因子産生機序に関するふたつの仮説。Mebio 1990;7: 90-94.
土屋尚之：重症筋無力症ーアセチルコリンリセプターα鎖と単純ヘルペスウイルスタイプ１の分子相同性について。臨床免疫 1990;22:1057-1060.
土屋尚之：自己免疫疾患とIV型アレルギー（自己免疫疾患とＴ細胞)。日本臨床 1990;48 (1990年増刊号、臨床免疫）: 752-756.
土屋尚之：合併症として注意すべき病態ー重症筋無力症（特集Sjögren症候群）。リウマチ科 1990;3: 274-278.
吉野谷定美、高橋孝喜、當間重人、土屋尚之：血漿交換。 Medical Practice 1988; 5:1617-1623.
土屋尚之、諸井泰興：CREST症候群。アレルギーの臨床 1986;6:89.
土屋尚之、宮本昭正：病因と診療のポイントー肺疾患。臨床医 1986;12: 698-699.
土屋尚之、高橋孝喜、吉野谷定美：C1q 固相化酵素抗体法による免疫複合体検出法とその問題点。臨床免疫1985;17:1114-1119.

その他

土屋尚之：７月の北欧のエピソード。医学のあゆみ 2004;210: 764-765.
土屋尚之：ワンポイント・アドバイス　多因子疾患は本当に複雑。Medical Practice 2004;21:1005.
土屋尚之：学会だより　第43回日本人類遺伝学会。現代医療 1999;31:1062-1063.
土屋尚之: 強直性脊椎炎におけるHLA-B27の役割。らくちん（日本AS友の会会報）1994;4:10-16.
土屋尚之：HLAおよびリウマトイド因子関連（American College of Rheumatology リポート）。Immunology Frontier 1991;1: 42-44.