| 2012年 | Yamaguchi Y, Naiki T, Irie K*. (2012) Stau1 regulates Dvl2 expressionduring myoblast differentiation. BBRC in press. Biochem Biophys Res Commun. 417:427-432. |
| 2011年 | Ito W, Li X, Irie K, Mizuno T, Irie K*. (2011) RNA-Binding Protein Khd1 and Ccr4 Deadenylase Play Overlapping Roles in the Cell Wall Integrity Pathway in Saccharomyces cerevisiae. Eukaryot Cell. 10:1340-1347. |
| 2010年 | Mauchi N, Ohtake Y, Irie K*. (2010) Stability control of MTL1 mRNA by the RNA-binding protein Khd1p in yeast. Cell Struct Funct. 35:95-105. |
| 2009年 | Fukuda T, Naiki T, Saito M, Irie K. hnRNP K interacts with RNA binding motif protein 42 and functions in the maintenance of cellular ATP levels during stress conditions. . Genes Cells. 2009. 14(2):113-128. 入江賢児 RNA局在の制御 蛋白質核酸酵素１２月号増刊「mRNAプログラム 多様性と非対称性の獲得戦略」 |
| 2008年 | Hasegawa Y, Irie K, Gerber AP. Distict roles for Khd1p in the localization and expression of bud-localizaed mRNAs in yeast. RNA. 2008 Sep. 19 Yamaguchi Y, Oohinata R, Naiki T, Irie K. Stau1 negatively regulates myogenic differentiation in C2C12 cells. Genes Cells. 2008. Jun;13(6):583-92. |
| 2007年 | 入江賢児 酵母におけるmRNA局在と局所的翻訳の制御機構 実験医学1月号特集「翻訳制御-RNAが支配する生命現象の根幹」25, 31-38 (2007) Ooshio T, Fujita N, Yamada A, Sato T, Kitagawa Y, Okamoto R, Nakata S, Miki A, Irie K, Takai Y. Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions. J. Cell Sci. 2007 120:2352-65. [PubMed] Wakamatsu K, Ogita H, Okabe N, Irie K, Tanaka-Okamoto M, Ishizaki H, Ishida-Yamamoto A, Iizuka H,Miyoshi J, Takai Y. Up-regulation of loricrin expression by cell adhesion molecule nectin-1 through Rap1-ERK signaling in keratinocytes. J.Biol. Chem. 2007. 282: 18173-81. [PubMed] Naiki T, Saijou E, Miyaoka Y, Sekine K, Miyajima A. TRB2, a mouse Tribbles ortholog, suppresses adipocyte differentiation by inhibiting AKT and C/EBPbeta. JBiol Chem. 2007 Aug 17;282(33):24075-82. [PubMed] |
| 2006年 |
Sato, T., Fujita, N., Yamada, A., Ooshio, T., Okamoto, R., Irie, K., and Takai, Y. (2006) Regulation of the assembly and adhesion activity of E-cadherin by nectin and afadin for the formation of adherens junctions in Madin-Darby Canine Kidney Cells. J Biol Chem., 281, 8, 5288-5299 Yamada, A., Fujita, N., Sato, T., Okamoto, R., Ooshio, T., Hirota, T., Morimoto, K., Irie, K., and Takai, Y. (2006) Requirement of nectin, but not cadherin, for formation of claudin-based tight junctions in annexin II-knockdown MDCK cells. Oncogene, 25, 37, 5085-5102 Inagaki, M., Irie, K., Ishizaki, H., Tanaka-Okamoto, M., Miyoshi, J., and Takai, Y. (2006) Role of cell adhesion molecule nectin-3 in spermatid development. Genes Cells, 11, 9, 1125-1132 |
| 2005年 |
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y. Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. Development. 2005;132:1525-1537. [PubMed] Hirota T, Irie K, Okamoto R, Ikeda W, Takai Y. Transcriptional activation of the mouse Necl-5/Tage4/PVR/CD155 gene by fibroblast growth factor or oncogenic Ras through the Raf-MEK-ERK-AP-1 pathway. Oncogene. 2005;24:2229-2235. [PubMed] Yamada A, Irie K, Hirota T, Ooshio T, Fukuhara A, Takai Y. Involvement of the annexin II-S100A10 complex in the formation of E-cadherin-based adherens junctions in Madin-Darby canine kidney cells. J Biol Chem. 2005;280:6016-6027. [PubMed] Okamoto R, Irie K, Yamada A, Katata T, Fukuhara A, Takai Y. Recruitment of E-cadherin associated with alpha- and beta-catenins and p120ctn to the nectin-based cell-cell adhesion sites by the action of 12-O-tetradecanoylphorbol-13-acetate in MDCK cells. Genes Cells. 2005;10:435-445. [PubMed] Sato T, Irie K, Okamoto R, Ooshio T, Fujita N, Takai Y. Common signaling pathway is used by the trans-interaction of Necl-5/Tage4/PVR/CD155 and nectin and that of nectin and nectin during the formation of cell-cell adhesion. Cancer Sci.2005;96:578-579. |
| 2004年 |
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y. Roles and modes of action of nectins in cell-cell adhesion. Semin Cell Dev Biol. 2004;15:643-656. [PubMed] Tadauchi T, Inada T, Matsumoto K, Irie K. Posttranscriptional regulation of HO expression by the Mkt1-Pbp1 complex. Mol Cell Biol. 2004;24:3670-3681. [PubMed] Ooshio T, Irie K, Morimoto K, Fukuhara A, Imai T, Takai Y. Involvement of LMO7 in the association of two cell-cell adhesion molecules, nectin and E-cadherin, through afadin and alpha-actinin in epithelial cells. J Biol Chem. 2004;279:31365-31373. [PubMed] Yamamoto Y, Irie K, Asada M, Mino A, Mandai K, Takai Y. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. Oncogene 2004;23:3889-3897. [PubMed] Yamada A, Irie K, Fukuhara A, Ooshio T, Takai Y. Requirement of the actin cytoskeleton for the association of nectins with other cell adhesion molecules at adherens and tight junctions in MDCK cells. Genes Cells 2004;9:843-855. [PubMed] Sato T, Irie K, Ooshio T, Ikeda W, Takai Y. Involvement of heterophilic trans-interaction of Necl-5/Tage4/PVR/CD155 with nectin-3 in formation of nectin- and cadherin-based adherens junctions. Genes Cells 2004;9:791-799. [PubMed] Asada M, Irie K, Yamada A, Takai Y. Afadin- and alpha-actinin-binding protein ADIP directly binds beta’-COP, a subunit of the coatomer complex. Biochem Biophys Res Commun. 2004;321:350-354. [PubMed] Yamamoto Y, Irie K, Kurihara H, Sakai T, Takai Y. Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. Biochem Biophys Res Commun. 2004;315:1120-1125. [PubMed] 入江賢児、池田わたる、高井義美 （2004）細胞増殖・運動・接着シグナルのクロストーク：ネクチンとネクチン様分子の機能と作用機構 日本学術振興会［学術月報］57巻8号：38頁−44頁 |
| 2003年 |
Toi H, Fujimura-Kamada K, Irie K, Takai Y, Todo S, Tanaka K. She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae. Mol Biol Cell 2003;14：2237-2249 [PubMed] Takai Y Irie K, Shimizu K, Sakisaka T, Ikeda W, Nectins and nectin-like molecules: Roles in cell adhesion, migration and polarization. Cancer Sci. 2003; 94:655-667. [PubMed] Asada M, Irie K, Morimoto K, Yamada A, Ikeda W, Takeuchi M, Takai Y. ADIP, a novel afadin- and a-actinin-binding protein localized at cell-cell adherens junctions. J Biol Chem. 2003;278:4103-4111 [PubMed] Katata T, Irie K, Fukuhara A, Kawakatsu T, Yamada A, Shimizu K, Takai Y. Involvement of nectin in the localization of IQGAP1 at the cell-cell adhesion sites through the actin cytoskeleton in Madin-Darby canine kidney cells. Oncogene 2003;22:2097-2109 [PubMed] Yamada A, Irie K, Deguchi-Tawarada M, Ohtsuka T, Takai Y. Nectin-dependent localization of synaptic scaffolding molecule (S-SCAM) at the puncta adherentia junctions formed between the mossy fibre terminals and the dendrites of pyramidal cells in the CA3 area of the mouse hippocampus. Genes Cells 2003;8:985-994 [PubMed] Inagaki M, Irie K, Deguchi-Tawarada M, Ikeda W, Ohtsuka T, Takeuchi M, Takai Y. Nectin-dependent localization of ZO-1 at puncta adhaerentia junctions between the mossy fiber terminals and the dendrites of the pyramidal cells in the CA3 area of adult mouse hippocampus. J Comp Neuro. 2003;460:514-5242. [PubMed] Honda T, Shimizu K, Fukuhara A, Irie K, Takai Y. Regulation by nectin of the velocity of the formation of adherens junctions and tight junctions. Biochem Biophys Res Commun. 2003;306:104-109. [PubMed] Honda T, Shimizu K, Kawakatsu T, Yasumi M, Shingai T, Fukuhara A, Ozaki-Kuroda K, Irie K, Nakanishi H, Takai, Y. Antagonistic and agonistic effects of an extracellular fragment of nectin on formation of E-cadherin-based cell-cell adhesion. Genes Cells 2003;8:51-63. [PubMed] Honda T, Shimizu K, Kawakatsu T, Fukuhara A, Irie K, Nakamura T, Matsuda M, Takai Y. Cdc42 and Rac small G proteins activated by trans-interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts. Genes Cells 2003;8:481-491. [PubMed] 入江賢児、高井義美：細胞間接着の解析法 ネクチン-アファディン系を例として、「ポストシークエンスタンパク質実験法 構造・機能解析の実際」、大島泰郎、鈴木紘一、藤井義明、村松 喬編、東京化学同人、東京、2003;112-125. 堅田龍生、入江賢児、高井義美 上皮細胞におけるネクチン-アファディン系に よる細胞間接着の制御機構、蛋白質核酸酵素、2003;48：105-112. |
| 2002年 |
Irie K, Tadauchi T, Takizawa PA, Vale RD, Matsumoto K, Herskowitz I. The Khd1 protein, which has three KH RNA-binding motifs, is required for proper localization of ASH1 mRNA in yeast. EMBO J. 2002;21:1158-1167 [PubMed] Ozaki-Kuroda K, Nakanishi H, Ohta H, Tanaka H, Kurihara H, Mueller S, Irie K, Ikeda W, Sakai T, Wimmer E, Nishimune Y, Takai Y. Nectin couples cell-cell adhesion and actin scaffold at heterotypic adherens junction in testis. Curr Biol. 2002;13:1145-1150 [PubMed] Tanaka Y, Irie K, Hirota T, Sakisaka T, Nakanishi H, Takai, Y. Ectodomain shedding of nectin-1alpha by SF/HGF and TPA in MDCK cells. Biochem Biophys Res Commun. 2002;299:472-478 [PubMed] Fukuhara A, Irie K, Nakanishi H, Takekuni K, Kawakatsu T, Ikeda W, Yamada A, Katata T, Honda T, Sato T, Shimizu K, Ozaki H, Horiuchi H, Kita T, Takai, Y. Involvement of nectin in the localization of junctional adhesion molecule at tight junctions. Oncogene 2002;21:7642-7655 [PubMed] Fukuhara A, Irie K, Yamada A, Katata T, Honda T, Shimizu K, Nakanishi H, Takai Y. Role of nectin in organization of tight junctions in epithelial cells. Genes Cells 2002;7:1059-1072 [PubMed] Momose Y, Honda T, Inagaki M, Shimizu K, Irie K, Nakanishi H, Takai Y. Role of the second immunoglobulin-like loop of nectin in cell-cell adhesion. Biochem Biophys Res Commun. 2002;293:45-49 [PubMed] Nishihama R, Soyano T, Ishikawa M, Araki S, Tanaka H, Asada T, Irie K, Ito M, Terada M, Banno H, Yamazaki Y, Machida Y. Expansion of the cell plate in plant cytokinesis requires a kinesin-like protein/MAPKKK complex. Cell 2002;109:87-99. [PubMed] 入江賢児、多々内智史、松本邦弘 酵母における細胞極性形成と非対称分裂の制御機構、実験医学、2002;20：101-106. 山本泰憲、入江賢児、中西宏之、高井義美 ネクチン-アファディン系による細胞間接着の形成機構、実験医学、2002;20：249-257. |
| 2001年 |
Tadauchi T, Matsumoto K, Herskowitz I, Irie K. Post-transcriptional regulation through the HO 3'-UTR by Mpt5, a yeast homolog of Pumilio and FBF. EMBO J. 2001;20:552-561. [PubMed] Ozaki-Kuroda K, Yamamoto Y, Nohara H, Kinoshita M, Fujiwara T, Irie K, Takai Y. Dynamic localization and function of Bni1p at the sites of directed growth in Saccharomyces cerevisiae. Mol Cell Biol 2001;21:827-839. [PubMed] Yokoyama S, Tachibana K, Nakanishi H, Yamamoto Y, Irie K, Mandai K, Nagafuchi A, Monden M, Takai Y. α-catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin. Mol Biol Cell 2001;12:1595-1609. [PubMed] Inoue H, Tateno M, Fujimura-Kamada K, Takaesu G, Adachi-Yamada T, Ninomiya-Tsuji J, Irie K, Nishida Y, Matsumoto K. A Drosophila MAPKKK, D-MEKK1, mediates stress responses through activation of p38 MAPK. EMBO J. 2001;20:5421-5430. [PubMed] 入江賢児、中西宏之、高井義美 細胞の接着と運動のしくみ、「細胞の形態形成の基本メカニズム」、高井義美、池田康夫、尾崎由基男、島田和幸、丸山征郎編、金芳堂、京都、2001;1-12. |
| 2000年以前の代表的な論文 ■MAPキナーゼのシグナル伝達機構 | |
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Irie K, Takase M, Lee KS, Levin D, Araki H, Matsumoto K, Oshima Y. MKK1 and MKK2, encoding Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol. 1993;13:3076-3083. [PubMed] Lee KS, Irie K, Gotoh Y, Watanabe Y, Araki H, Nishida E, Matsumoto K, Levin D. A yeast mitogen-activated protein kinase homolog (MPK1) mediates signalling by protein kinase C. Mol Cell Biol. 1993;13:3067-3075. [PubMed] Irie K, Gotoh Y, Yashar BM, Errede B, Nishida E, Matsumoto K. Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase. Science 1994;265:1716-1719. [PubMed] Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. Identification of a member of the MAPKKK family as a potential mediator of TGF-b signal transduction. Science 1995;270:2008-2011. [PubMed] Watanabe Y, Irie K, Matsumoto K. Yeast RLM1 encodes a serum response factor-like protein that may function downstream of the Mpk1 (Slt2) mitogen-activated protein kinase pathway. Mol Cell Biol. 1995;15:5740-5749. [PubMed] Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1, an activator for TAK1 MAPKKK regulating the TGF-b signal transduction. Science 1996;272:1179-1182. [PubMed] Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 1997;275:90-94. [PubMed] Watanabe Y, Takaesu G, Hagiwara M, Irie K, Matsumoto K. Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) MAP kinase pathway. Mol Cell Biol. 1997;17:2615-2623. [PubMed] Suzanne M, Irie K, Glise B, Agnes F, Mori E, Matsumoto K, Noselli S. The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development. Genes Dev. 1999;13:1464-1474. [PubMed] Inagaki M, Schmelzle T, Yamaguchi K, Irie K, Hall MN, Matsumoto K. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast. Mol Cell Biol. 1999;19:8344-8352. [PubMed] Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 2000;5:649-658. [PubMed] 入江賢児、松本邦弘 酵母をモデル系としたMAPキナーゼカスケード、実験医学、1995;13：554-558. 入江賢児、澁谷浩司 MAPキナーゼキナーゼキナーゼTAK1とTGF-βシグナル伝達系、実験医学、1996;14：2616-2622. 入江賢児、松本邦弘 シグナル伝達系から細胞のがん化が見えてくる、「ネオ生物学シリーズ ゲノムから見た新しい生物像〈第4巻〉 酵母 究極の細胞」、柳田充弘編、共立出版、東京、1996;40-45. |
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| ■細胞周期の制御 | |
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Irie K, Nomoto S, Miyajima I, Matsumoto K. SGV1 encodes a CDC28/cdc2-related kinase required for a Ga subunit-mediated adaptive response to pheromone in S. cerevisiae. Cell 1991;65:785-795. [PubMed] Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K. New human gene encoding a positive modulator of HIV Tat-mediated transactivation. Nature 1992;357:700-702. [PubMed] |
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| ■酵母プラスミドの分配機構 | |
| Irie K, Araki H, Oshima Y. Mutations in a Saccharomyces cerevisiae host showing increased holding stability of the heterologous plasmid pSR1. Mol Gene Genet. 1991;225:257-265. [PubMed] | |
