2022年

Overexpression of Plasmalemmal Vesicle-Associated Protein-1 Reflects Glomerular Endothelial Injury in the Cases of Proliferative Glomerulonephritis With Monoclonal IgG Deposits.
Anri Sawada, Kunio Kawanishi, Yuto Igarashi, Sekiko Taneda, Motoshi Hattori, Hideki Ishida, Kazunari Tanabe, Junki Koike, Kazuho Honda, Yoji Nagashima and Kosaku Nitta.
Kidney International Reports. Received 6 June 2022, Revised 30 September 2022, Accepted 10 October 2022, Available online 19 October 2022.

TGFβ selects for pro-stemness over pro-invasive phenotypes during cancer cell epithelial-mesenchymal transition.
Yutaro Tsubakihara, Yae Ohata, Yukari Okita, Shady Younis, Jens Eriksson, Mikael E Sellin, Jiang Ren, Peter Ten Dijke, Kohei Miyazono, Atsuhiko Hikita, Takeshi Imamura, Mitsuyasu Kato, Carl-Henrik Heldin, Aristidis Moustakas.
Mol Oncol. 2022 Jun;16(12):2330-2354. doi: 10.1002/1878-0261.13215. Epub 2022 Apr 10.

Development of a Novel Anti−CD44 Monoclonal Antibody for Multiple Applications against Esophageal Squamous Cell Carcinomas.
Nohara Goto, Hiroyuki Suzuki, Tomohiro Tanaka, Teizo Asano, Mika K. Kaneko and Yukinari Kato.
Int J Mol Sci. 2022, 23(10), 5535; https://doi.org/10.3390/ijms23105535.

Glycoprotein NMB promotes tumor formation and malignant progression of laryngeal squamous cell carcinoma.
Lev Manevich, Yukari Okita, Yasuhito Okano, Takehito Sugasawa, Kunio Kawanishi, Thanasis Poullikkas, Linda T. L. Dang Cao, Ling Zheng, Masahiro Nakayama, Shin Matsumoto, Keiji Tabuchi, Mitsuyasu Kato.
Cancer Sci. 2022 Apr 1. doi: 10.1111/cas.15359. Online ahead of print.

PCSK9 functions in promoting cardiovascular diseases: recent evidence about its association with platelet activation-induced myocardial infarction.
Meidi Utami Puteri, Nuriza Ulul Azmi, Mitsuyasu Kato, Fadlina Chany Saputri.
Life(Basel). 2022 Jan 27;12(2):190. doi: 10.3390/life12020190.

2021年

Antiproliferative and antioxidant potentials of bioactive edible vegetable fraction of Achyranthes ferruginea Roxb. in cancer cell line.
A. S. M. Ali Reza, Md Anwarul Haque, Joy Sarker, Mst. Samima Nasrin, Md. Mahbubur Rahman, Abu Montakim Tareq, Zidan Khan, Mamunur Rashid, Md. Golam Sadik, Toshifumi Tsukahara, AHM Khurshid Alam.
Food Sci Nutr. 2021;9: 3777–3805. DOI: 10.1002/fsn3.2343.

Bioactive metabolites of Blumea lacera attenuate anxiety and depression in rodents and computer- aided model.
Md. Amjad Hossen, A. S. M. Ali Reza, Md. Badrul Amin, Mst. Samima Nasrin, Tawhidul Amin Khan, Md. Habibur Rahman Rajib, Abu Montakim Tareq, Md Anwarul Haque, Md. Atiar Rahman, Md. Areeful Haque.
Food Sci Nutr. 2021;9: 3836–3851.www.foodscience-nutrition.com. DOI: 10.1002/fsn3.2362.

Antioxidative role of palm grass rhizome ameliorates anxiety and depression in experimental rodents and computer-aided model.
Md. Akramul Hoque, Shabbir Ahmad, Nishan Chakrabarty, Mohammad Forhad Khan, Mohammad Shah Hafez Kabir, Afrina Brishti, Md. Obayed Raihan, A.H.M.Khurshid Alam, Md Anwarul Haque, Mst. Samima Nasrin, Md. Areeful Haque, A.S.M.Ali Reza.
Heliyon. 7(10), October 2021, e08199.

PMEPA1/TMEPAI Is a Unique Tumorigenic Activator of AKT Promoting Proteasomal Degradation of PHLPP1 in Triple-Negative Breast Cancer Cells.
Haque MA, Abdelaziz M, Puteri MU, Vo Nguyen TT, Kudo K, Watanabe Y, Kato M.
Cancers, 2021 Sep 30;13(19):4934. doi: 10.3390/cancers13194934.

Glycoprotein non-metastatic melanoma protein B functions with growth factor signaling to induce tumorigenesis through its serine phosphorylation.
Wang C, Okita Y, Zheng L, Shinkai Y, Manevich L, Chin JM, Kimura T, Suzuki H, Kumagai Y, Kato M.
Cancer Sci, 2021 Oct;112(10):4187-4197. doi: 10.1111/cas.15090. Epub 2021 Aug 10.

Polyvinyl alcohol scaffolds and supplementation support 3D and sphere culturing of human cancer cell lines by reducing apoptosis and promoting cellular proliferation.
Okita Y, Zheng L, Kawanishi K, Miyoshi H, Yanagihara K, Kato M.
Genes Cells, 2021 May;26(5):336-343. doi: 10.1111/gtc.12843. Epub 2021 Mar 23.

2020年

PMEPA1/TMEPAI isoforms function via its PY and Smad-interaction motifs for tumorigenic activities of breast cancer cells.
Puteri MU, Watanabe Y, Wardhani BWK, Amalia R, Abdelaziz M, Kato M.
Genes Cells, 2020 Jun;25(6):375-390. doi: 10.1111/gtc.12766. Epub 2020 Apr 29.

TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel.
Wardhani BWK, Puteri MU, Watanabe Y, Louisa M, Setiabudy R, Kato M.
J Exp Pharmacol. 2020 Jan 23;12:17-26. doi: 10.2147/JEP.S235233. eCollection 2020.

2019年

THG-1 suppresses SALL4 degradation to induce stemness genes and tumorsphere formation through antagonizing NRBP1 in squamous cell carcinoma cells.
Hwang J, Haque MA, Suzuki H, Dijke PT, Kato M.
Biochem Biophys Res Commun. 2020 Mar 5; 523(2):307-314. doi: 10.1016/j.bbrc.2019.11.149. Epub 2019 Dec 19.

Promotion of cellular senescence by THG-1/TSC22D4 knockout through activation of JUNB.
Zhang X, Koga N, Suzuki H, Kato M.
Biochem Biophys Res Commun. 2020 Feb 19; 522(4):897-902. doi: 10.1016/j.bbrc.2019.11.145. Epub 2019 Dec 3.

A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment.
Huynh LK, Hipolito CJ, Ten Dijke P.
Biomolecules. 2019; 9(11):743; doi: org/10.3390/biom9110743. PMID: 31744193

Generation of non-standard macrocyclic peptides specifically binding TSC-22 homologous gene-1.
Tran STP, Hipolito CJ, Suzuki H, Xie R, Kim Tuyen HD, Dijke PT, Terasaka N, Goto Y, Suga H, Kato M.
Biochem Biophys Res Commun. 2019 Aug 20;516(2):445-450. doi: 10.1016/j.bbrc.2019.06.035. Epub 2019 Jun 18.

Role of the kringle-like domain in glycoprotein NMB for its tumorigenic potential.
Xie R, Okita Y, Ichikawa Y, Muhammad FA, Huynh Dam KT, Tran SPT, Kato M.
Cancer Sci. 2019 Jul;110(7):2237-2246. doi: 10.1111/cas.14076. Epub 2019 Jun 26.

TMEPAI/PMEPA1 inhibits Wnt signaling by regulating β-catenin stability and nuclear accumulation in triple negative breast cancer cells.
Amalia R, Abdelaziz M, Puteri MU, Hwang J, Anwar F, Watanabe Y and Kato M.
Cell Signal. 2019 Jul;59:24-33. doi: 10.1016/j.cellsig.2019.03.016. Epub 2019 Mar 16.

Decreased sensitivity of several anticancer drugs in TMEPAI knockout triple-negative breast cancer cells.
Wardhani BWK, Puteri MU, Watanabe Y, Louisa M, Setiabudy R, Kato M.
Medical J. Indonesia. 28: 110-115, 2019. May16; 2019. doi: 10.13181/mji.v28i2.2687

PMEPA1/TMEPAI knockout impairs tumor growth and lung metastasis in MDA-MB-231 cells without changing monolayer culture cell growth.
Abdelaziz M, Watanabe Y, Kato M.
J Biochem. 2019 May 1;165(5):411-414. doi: 10.1093/jb/mvz022.

Stereodivergent Synthesis of Bispyrrolidinoindoline Alkaloidal Scaffolds and Generation of a Lead Candidate with Stereospecific Antiproliferative Activity.
Wada M, Suzuki H, Kato M, Oikawa H, Tsubouchi A and Oguri H
Chembiochem. 2019 May 15;20(10):1273-1281. doi: 10.1002/cbic.201800815. Epub 2019 Mar 28.

2018年

Cell-surface GPNMB and induction of stemness.
Okita Y, Chen C, Kato M.
Oncotarget. 2018 Dec 18;9(99):37289-37290. doi: 10.18632/oncotarget.26472. eCollection 2018 Dec 18. (Editorial)

Glycoprotein nmb is exposed on the surface of dormant breast cancer cells and induces stem cell-like properties.
Chen C, Okita Y, Watanabe Y, Abe F, Fikry MA, Ichikawa Y, Suzuki H, Shibuya A and Kato M.
Cancer Res. 2018; 78(22): 6424-6435. doi: 10.1158/0008-5472.CAN-18-0599. Epub 2018 Sep 17.

The possible repositioning of an oral anti-arthritic drug, auranofin, for Nrf2-activating therapy: The demonstration of Nrf2-dependent anti-oxidative action using a zebrafish model.
Fuse Y, Endo Y, Araoi S, Daitoku H, Suzuki H, Kato M and Kobayashi M.
Free Radic. Biol Med. 2018; 115: 405-411.

Roles of Glycoprotein nmb in breast cancer formation and malignant progression.
Okita Y, Chen C, Suzuki H and Kato M.
Cancer Sci. 2018; 109(1): 1041-1041.

Cell surface expression of GPNMB on dormant breast cancer stem cells.
Chen C, Okita Y and Kato M.
Cancer Sci. 2018; 109(1): 630-630.

2017年

Regulation of c-MYC transcriptional activity by transforming growth factor-beta 1-stimulated clone 22.
Zheng L, Suzuki H, Nakajo Y, Nakano A, and Kato M.
Cancer Sci. 2017; 109(2): 395-402.

Knock-out transmembrane prostate androgen-induced protein gene suppressed triple-negative breast cancer cell proliferation.
Wardhani BWK, Puteri MU, Watanabe Y, Louisa M, Setiabudy R and Kato M.
Med J Indonesia. 2017; 26(3): 178-182.

TMEPAI genome editing in triple negative breast cancer cells.
Wardhani BWK, Puteri MU, Watanabe Y, Louisa M, Setiabudy R and Kato M.
Med J Indonesia. 2017; 26(1): 14-18.

TIF1β is phosphorylated at serine 473 in colorectal tumor cells through p38 mitogen-activated protein kinase as an oxidative defense mechanism.
Shen LT, Chou HE. and Kato M.
Biochem Biophys Res Commun.2017 Oct 21;492(3):310-315. doi: 10.1016/j.bbrc.2017.08.117. Epub 2017 Aug 31.

The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.
Okita Y, Kimura M, Rudy X, Chen C, Shen LTW, Kojima Y, Suzuki H, Muratani M, Saitoh M, Semba K, Heldin CH and Kato M.
Sci Signal. 2017 Apr 11; 10(474). doi: 10.1126/scisignal.aak9397.

Targeting TGF-β Signaling in Cancer.
Colak S, Ten Dijke P.
Trends in cancer. 2017 Jan; 3(1): 56-71. doi: 10.1016/j.trecan.2016.11.008.

Repression of Smad3 by Stat3 and c-Ski/SnoN induces gefitinib resistance in lung adenocarcinoma.
Makino Y, Yoon JH, Bae E, Kato M, Miyazawa K, Ohira T, Ikeda N, Kuroda M and Mamura M.
Biochem Biophys Res Commun. 2017 Mar 4; 484(2): 269-277. doi: 10.1016/j.bbrc.2017.01.093.

2016年

A current perspective on applications of macrocyclic-peptide-based high-affinity ligands.
Leenheer D, Ten Dijke P and Hipolito CJ.
Biopolymers. 2016 Nov; 106(6): 889-900. doi: 10.1002/bip.22900.

In Vitro Selected Macrocyclic Peptides: Tools for Regulating the Conformational Freedom of Transmembrane Proteins.
Hipolito CJ, Nishio K and Suga H.
Yakugaku Zasshi. 2016; 136(2): 191-6. doi: 10.1248/yakushi.15-00229-4.

Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1.
Lin J, Kato M, Nagata K and Okuwaki M.
Nucleic Acids Res. 2016 Dec 20. doi: 10.1093/nar/gkw1285. [Epub ahead of print] PMID: 28003476.

Regulation of bone morphogenetic protein signaling by ADP-ribosylation.
Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH and Moustakas A.
J Biol Chem. 2016 Apr 21. pii: jbc.M116.729699. [Epub ahead of print] PMID: 27129221.

The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.
Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH and Moustakas A.
Oncotarget. 7(2): 1120-1143, 2016. doi: 10.18632/oncotarget.6683. PMID: 26701726.

Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, Bartholin L and Moustakas A.
Methods Mol Biol. 1344: 147-181, 2016. doi: 10.1007/978-1-4939-2966-5_9. PMID: 26520123. (IF: 1.29)

β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development.
Abdellatif AM, Oishi H, Itagaki T, Jung Y, Shawki HH, Okita Y, Hasegawa Y, Suzuki H, El-Morsy SE, El-Sayed MA, Shoaib MB, Sugiyama F and Takahashi S.
PLoS One.11(2): e0150010, 2016. doi: 10.1371/journal.pone.0150010. eCollection 2016. 2016 Feb 22, PMID: 26901059.

Regulation of the TMEPAI Promoter by TCF7L2: the C-terminal Tail of TCF7L2 is Essential to Activate the TMEPAI Gene.
Nakano N, Kato M andItoh S.
J Biochem. 159: 27-30, 2016. doi:10.1093/jb/mvv117. Epub 2015 Nov 20. PMID: 26590303. (3.073)

2015年

Arf6 regulates tumour angiogenesis and growth through HGF-induced endothelial β1 integrin recycling.
Hongu T, Funakoshi Y, Fukuhara S, Suzuki T, Sakimoto S, Takakura N, Ema M, Takahashi S, Itoh S, Kato M, Hasegawa H, Mochizuki N and Kanaho Y.
Nat Commun. 2015; 6: 7925. doi: 10.1038/ncomms8925.

Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation.
Yoon JH, Sudo K, Kuroda M, Kato M, Lee IK, Han JS, Nakae S, Imamura T, Kim J, Ju JH, Kim DK, Matsuzaki K, Weinstein M, Matsumoto I, Sumida T and Mamura M.
Nat Commun. 62015 Jul21;6: 7600. doi: 10.1038/ncomms8600.

Cooperative induction of transmembrane prostate androgen induced protein TMEPAI/PMEPA1 by transforming growth factor-β and epidermal growth factor signaling.
Azami S, Vo Nguyen TT, Watanabe Y and Kato M.
Biochem Biophys Res Commun. 2015; 456(2): 580-585.

2014年

病理標本の3次元再構築によるがんの特性の研究.
加藤光保、永田毅.
日本機械学会2014年度年次大会講演論文集. 2014.

Fine-Tuning of Smad Protein Function by Poly(ADP-Ribose) Polymerases and Poly(ADP-Ribose) Glycohydrolase during Transforming Growth Factor β Signaling.
Dahl M, Maturi V, Lonn P, Papoutsoglou P, Zieba A, Vanlandewijck M, van der Heide LP, Watanabe Y, Soderberg O, Hottiger MO, Heldin CH and Moustakas A.
PLoS One. 2014; 9(8): e103651. doi: 10.1371/journal.pone.0103651. eCollection 2014.

C18ORF1: A Novel Negative Re,ulator of TGF-β Signaling.
Nakano N, Maeyama K, Sakata N, Itoh F, Akatsu R, Nakata M, Katsu Y, Ikeno S, Togawa Y, Vo Nguyen TT, Watanabe Y, Kato M and Itoh S.
J Biol Chem. 2014; 289(18): 12680-12692.

TMEPAI/PMEPA1 enhances Tumorigenic Activities in Lung Cancer Cells.
Vo Nguyen TT, Watanabe Y, Shiba A, Noguchi M, Itoh S and Kato M.
Cancer Sci. 2014; 105(3): 334-341.

上皮間葉移行
加藤光保沖田結花里
病理と臨床. 2014; 32(10): 1163-1167.

TGF-βシグナル伝達による酸化ストレス制御機構
沖田結花里加藤光保
医学のあゆみ. 2014; 250(6, 7): 511-515.

2013年

Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing Eomesodermin in cytotoxic T lymphocytes.
Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK and Mamura M.
EMBO Mol Med. 2013; 5: 1720-1739.

連続切片病理画像における位置合わせと細胞カウント
永田毅、不破敦、加藤光保
みずほ情報総研技報. 2013; 5(1): 1-6.

Transforming Growth Factor-β Induces transcription factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene.
Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Yamamoto M, Ogami T, Koinuma D and Kato M.
J Biol Chem. 2013; 288(28): 20658-20667.

Screening quality for Ca2+-activated potassium channel in IonWorks Quattro is greatly improved by using BAPTA-AM and ionomycin.
Ido K, Ohwada T, Yasutomi E, Yoshinaga T, Arai T, Kato M and Sawada K.
J Pharmacol Toxicol Methods. 2013; 67(1): 16-24.