2018年 7月 12日
Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain
[Forebrain Ptf1a Is Required for Sexual Differentiation of the Brain]
• Ptf1a is expressed near the ventricular zone in the developing hypothalamus at E10–E16
• Ptf1a cKO male and female mice lose sex-biased behaviors and gene expression
• Kisspeptin neuron development is severely disrupted in Ptf1a-deficient hypothalamus
• RNA-seq analysis reveals altered gene expression in non-cell-autonomous regulators