Contact

1-1-1 tennodai,tsukuba-shi,ibaraki-ken 305-8575, JAPAN
Laboratory of Gene Regulation
Graduate School of Comprehensive Human Sciences
University of Tsukuba

Publications

Original Publications

  • Wakao H, Yoshikiyo K, Koshimizu U, Furukawa T, Enomoto K, Matsunaga T, Tanaka T, Yasutomi Y, Yamada T, Minakami H, Tanaka J, Oda A, Sasaki T, Wakao R, Lantz O, Udagawa T, Sekiya Y, Higuchi K, Harada N, Nishimura K, Ohtaka M, Nakanishi M, Fujita H: Expansion of Functional Human Mucosal-Associated Invariant T Cells via Reprogramming to Pluripotency and Redifferentiation. Cell Stem Cells, Vol. 12, 546-558, 2013
  • Shiromoto Y, Kuramochi-Miyagawa S, Daiba A, Chuma S, Katanaya A, Katsumata A, Nishimura K, Ohtaka M, Nakanishi M, Nakamura T, Yoshinaga K, Asada N, Nakamura S, Yasunaga T, Kojima-Kita K, Itou D, Kimura T, Nakano T: GPAT2, a mitochondrial outer membrane protein, in piRNA biogenesis in germline stem cells. RNA, Vol. 19, 803-810, 2013
  • H.Tateno, A. Matsushima, K. Hiemori, Y. Onuma, Y. Ito, K. Hasehira, K. Nishimura, M. Ohtaka, S. Takayasu, M. Nakanishi, Y. Ikehara, M. Nakanishi, K. Ohnuma, T. Chan, M. Toyoda, H. Akutsu, A. Umezawa, M. Asashima, J. Hirabayashi: Podocalyxin is a Glycoprotein Ligand of the Human Pluripotent Stem Cell-Specific Probe rBC2LCN. Stem Cells Trans. Med., doi:10.5966/stcm.2012-0154 (2013)
  • T. Nishimura, S. Kaneko, A. Kawana-Tachikawa, Y. Tajima, H. Goto, D. Zhu, K. Nakayama-Hosoya, S. Iriguchi, Y. Uemura, T. Shimizu, N. Takayama, D. Yamada, K. Nishimura, M. Ohtaka, N. Watanabe, S. Takahashi, A. Iwamoto, H. Koseki, M. Nakanishi, K. Eto, H. Nakauchi: Generation of rejuvenated antigen-specific T cells by reprogramming to pluripotency and redifferentiation. Cell Stem Cells,Vol. 12, 114-126, 2013
  • K. Nishimura, M. Sano, M. Ohtaka, B. Furuta, Y. Umemura, Y. Nakajima, Y. Ikehara, T. Kobayashi, H. Segawa, S. Takayasu, H. Sato, K. Motomura, E. Uchida, T. Kanayasu-Toyoda, M. Asashima, H. Nakauchi, T. Yamaguchi, M. Nakanishi: Development of Defective and Persistent Sendai Virus Vector: a Unique Gene Delivery/Expression System Ideal for Cell Reprogramming. J. Biol. Chem.,Vol. 286, 4760-4771, 2011
  • N. Takayama, S. Nishimura, S. Nakamura, T. Shimizu, R. Ohnishi, H. Endo, T. Yamaguchi, M. Otsu,K. Nishimura, M. Nakanishi, A. Sawaguchi, R. Nagai, K. Takahashi, S. Yamanaka, H. Nakauchi, K. Eto: Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J. Exp. Med., Vol. 207, 2817-2830, 2010
  • K. Nishimura, H. Segawa, T. Goto, M. Morishita, A. Masago, H. Takahashi, Y. Ohmiya, T. Sakaguchi, M. Asada, T. Imamura, K. Shimotono, K. Takayama, T. Yoshida, M. Nakanishi: Persistent and stable gene expression by a cytoplasmic RNA replicon based on a noncytopathic variant Sendai virus. J. Biol. Chem., Vol. 282, 27383-27391, 2007
  • K. Nishimura, K. Ueda, E. Guwanan, S. Sakakibara, E. Do, E. Ohsaki, K. Yada, T. Okuno, K. Yamanishi:A posttranscriptional regulator of Kaposi's sarcoma-associated herpesvirus interacts with RNA-binding protein PCBP1 and controls gene expression through the IRES. Virology, Vol. 325, 364-378, 2004
  • K. Nishimura, K. Ueda, S. Sakakibara, E. Do, E. Ohsaki, T. Okuno, K. Yamanishi:A viral transcriptional activator of Kaposi's sarcoma-associated herpesvirus (KSHV) induces apoptosis, which is blocked in KSHV-infected cells. Virology, Vol. 316, 64-74, 2003
  • K. Nishimura, K. Ueda, S. Sakakibara, K. Ishikawa, J. Chen, T. Okuno, K. Yamanishi:Functional analysis of Kaposi's sarcoma-associated herpesvirus RTA in an RTA-depressed cell line. J. Hum. Virol., Vol. 4, 296-305, 2001
  • K. Nishimura, Y. Yasumura, K. Igarashi, S. Harashima, Y. Kakinuma: Transcription of some PHO genes in Saccharomyces cerevisiae is regulated by Spt7p. Yeast, Vol. 15, 1711-1717, 1999
  • K. Nishimura, Y. Yasumura, K. Igarashi, Y. Kakinuma: Involvement of Spt7p in vacuolar polyphosphate level of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun., Vol. 257, 835-838, 1999
  • K. Nishimura, K. Igarashi, Y. Kakinuma: Proton gradient-driven nickel uptake by vacuolar membrane vesicles of Saccharomyces cerevisiae. J. Bacteriol., Vol. 180, 1962-1964, 1998

Reviews and Books

  • 中西真人、西村健、大高真奈美、佐野将之、酒井菜絵子:細胞質で持続的に遺伝子を発現できる新規ベクターの開発と先端医療への応用、iPS細胞の産業的応用技術、シーエムシー出版、51-60頁、2009
  • 中西真人、西村健、大高真奈美、佐野将之:安全なiPS細胞作製に向けた新型センダイウイルスベクターの開発、幹細胞の分化誘導と応用、(株)エヌ・ティー・エス、108-118頁、2009
  • 中西真人、西村健、瀬川宏知、岡部潤、大高真奈美、暁波:持続発現型センダイウイルスベクターの開発と再生医療への応用、再生医療、Vol. 6、39-44頁、2007

Recent Presentations in Conferences

  • 西村健、成田孝仁、大高真奈美、高安聡子、佐野将之、福田綾、中西真人、久武幸司:SeVdpベクターを用いたiPS細胞の品質調節メカニズムの解析、第12回日本再生医療学会総会、2013年
  • K. Nishimura:Application of CYtoplasmic RNA vector Developed from Noncytopathic RNA Viruses to Stem Cell Engineering、The 2nd Meeting on RNA and Biofunctions-Asia Study、2013年
  • K. Nishimura, M. Ohtaka, S. Takayasu, M. Sano, K. Hisatake, M. Nakanishi:QUALITY CONTROL OF IPS CELLS BY UNIQUE GENE TRANSFER SYSTEM、International Society of Stem Cell Research 10th Annual Meeting、2012年
  • 西村健、大高真奈美、高安聡子、佐野将之、久武幸司、中西真人:RNA工学とウイルス学の融合による簡便かつ高効率なiPS細胞樹立方法の確立、第34回日本分子生物学会年会、2011年
  • K. Nishimura, M. Ohtaka, M. Sano, K. Hisatake, M. Nakanishi:Novel Cytoplasmic Persistent Expression RNA Vector Developed by Combination of RNA Biotechnology and Virology、NTU-JST joint Meeting on RNA &Biofunctions、2011年
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  • K. Nishimura:Development of Novel Cytoplasmic RNA Vectors Capable of Stable Gene Expression without Chromosomal Integration、The 2nd Leading Graduate Schools International Conference、2011年
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  • 西村健、大高真奈美、高安聡子、小林俊寛、小沼泰子、伊藤弓弦、大津真、中内啓光、浅島誠、中西真人:iPS細胞樹立に最適な形に進化させた持続発現型RNAベクターの開発、第10回日本再生医療学会総会、2011年
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  • 西村健、大高真奈美、佐野将之、梅村洋子、中西真人:細胞質持続発現型RNAベクターの開発、第12回日本RNA学会年会、2010年
  • 西村健、大高真奈美、佐野将之、古田美玲、内田恵理子、豊田淑江、山口照英、中西真人:細胞質持続発現型RNAベクターの開発と幹細胞研究への応用、第9回日本再生医療学会総会、2010年
  • K. Nishimura, M. Ohtaka, H. Segawa, B. Furuta, R. Uchida, T. Kanayasu-Toyoda, T. Yamaguchi, M. Nakanishi:DEVELOPMENT OF NOVEL CYTOPLASMIC RNA VECTOR CAPABLE OF STABLE GENE EXPRESSION WITHOUT CHROMOSOMAL INTEGRATION、International Society of Stem Cell Research 7th Annual Meeting、2009年

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Theme

---Analysis for transcriptional regulation on early stage of iPS cell production

---Analysis for quality control and epigenetic regulation on iPS cells

---Establishment of safe differentiation system by using persistent RNA vector

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