井原康夫　（東京大学・大学院医学系研究科）

1.Yamaguchi H, Sugihara S, Ogawa A, Ihara Y: Alzheimer β amyloid deposition, which is hastened by ApoE ε4 gene, precedes neurofibrillary pathology in the frontal association cortex of non-demented senior subjects. J Neuropathol Exp Neurol 60: 731-739, 2001

2.Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y: Accumulation of amyloid β-protein in the low-density membrane domain accurately reflects the extent of β-amyloid deposition in the brain. Am J Pathol 158: 2209-2218, 2001

3.Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y: Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. J Neuropathol Exp Neurol 60: 872-884, 2001

4.Gu Y, Misonou H, Sato T, Dohmae N, Takio K, Ihara Y: Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling g-secretase-like cleavage of Notch. J Biol Chem 276: 35235-35238, 2001

5.Utsunomiya I, Ren J, Taguchi K, Ariga T, Tai T, Ihara Y, Miyatake T: Immunohistochemical detection of verotoxin receptors in nervous system. Brain Res Protoc 8: 99-103, 2001

6.Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH: Collapsin response mediator protein-2 inhibits neuronal phospholipase D2 activity by direct interaction. J Biol Chem in press

田平　武　（国立療養所中部病院・長寿医療研究センター）

1.Poorkaj P, Grossman M, Steinbart E, Payami H, Sadovnick A, Nochlin D, Tabira T, Trojanowski JQ, Borson S, Galasko D, Reich S, Quinn B, Schellenberg G, Bird TD: Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol 58: 383-387, 2001

2.Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, Checler F, Araki W, Takahashi K, Tabira T: Apoptotoc neurons in Alzheimer’s disease frequently show intracellular Aβ42 labeling. J Alz Dis 3: 231-239, 2001

3.Kowalska A, Asada T, Arima K, Kumakiri C, Kozubski W, Takahashi K, Tabira T: Genetic analysis in patients with familial and sporadic frontotemporal dementia: Two tau mutations in only familial cases and no association with apolipoprotein ε4. Dement Geriat Cogn Disord 12: 387-392, 2001

4.Ohnishi T, Matsuda H, Tabira T, Asada T, Uno M: Changes in brain morphology in Alzheimer disease and normal aging: is Alzheimer disease an exaggerated aging process? Am J Neuroradiol 22: 1680-1685, 2001

5.Kotorii S, Takahashi K, Kamimura K, Nishio T, Arima K, Yamada H, Uyama E, Uchino M, Suenaga A, Matsumoto M, Rouleau G, Tabira T: Mutational analysis of the Notch3 gene in patients with suspected CADASIL syndrome: a direct DNA diagnosis for familial vascular leukoencephalopathy and dementia. Dement Geriat Cogn Disord 12: 185-193, 2001

6.Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A: Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10 +11-splice site in the tau gene. Ann Neurol 50: 117-120, 2001

7.Tabira T: Clioquinol’s return: cautions from Japan. (letter to the editor) Science. 292: 2251, 2001

8.Tanahashi H, Tabira T: Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production. Neurosci Lett 307: 9-12, 2001

9.Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T, Familial Alzheimer’s Disease Study Group (Arango J, Bird T, Van Broeckhoven C, Brooks W, Brown R, Cairns N, Cras P, Ellison D, Haltia M, Li K, Jorgensen A, Krill J, Lantos P, Lippa C, Martins R, Nochlin D, Pollen D, Rosenberg C, Rossor M, Tabira T): Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimer’s disease. Am J Pathol 158: 2165-2175, 2001

10.Araki W, Yuasa K, Takeda S, Takeda K, Shirotani K, Takahashi K, Tabira T: Proapoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. J Neurochem 79: 1-9, 2001

柳澤勝彦　（国立療養所中部病院・国立長寿医療研究センター）

1.Michikawa M, Gong J-S, Fan Q-W, Sawamura N, Yanagisawa K: A novel action of Alzheimer’s amyloid β-protein (Aβ): oligomeric Aβ promotes lipid efflux. J Neurosci 21: 7226-7235, 2001

2.Kakio A, Nishimoto S, Yanagisawa K, Kozutumi Y, Matsuzaki K: Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid. J Biol Chem 276: 24985-24990, 2001

3.Kawamura Y, Kikuchi A, Takada R, Takada S, Sudoh S, Shibamoto S, Yanagisawa K, Komano H: Inhibitory effect of presenilin 1 mutation on the Wnt signaling pathway by enhancement of β-catenin phosphorylation. Eur J Biochem 268: 3036-3041, 2001

4.Fan Q-W, Yu W, Senda T, Yanagisawa K, Michikawa M: Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. J Neurochem 80: 178-190, 2002

5.Fan Q-W, Isobe I, Asou H, Yanagisawa K, Michikawa M: Expression and regulation of apolipoprotein E receptors in the cells of the central nervous system in culture. J Am Aging Assoc 24: 1-10, 2001

6.Hayashi H, Igbavboa U, Hamanaka H, Kobayashi M, Fujita SC, Wood WG, Yanagisawa K: Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. NeuroReport in press

7.Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki T, Kitamura T,

8.Kawaichi M, Miyata T, Suzuki T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem in press

石浦章一　（東京大学・大学院総合文化研究科）

1.Sakaki M, Takahashi N, Sasagawa N, Arahata K, Ishiura S: Interaction between emerin and nuclear lamins. J Biochem 129: 321-327, 2001

2.Usuki F, Y.asutake A, Umehara F, Tokunaga H, Matsumoto M, Eto K, Ishiura S, Higuchi I: In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication in the rat. Neurosci Lett 304: 199-203, 2001

3.Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S: The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1: 152-156, 2001

4.Umeda T, Kouchi Z, Kawahara H, Tomioka S, Sasagawa N, Maeda T, Sorimachi H, Ishiura S, Suzuki K: Limited proteolysis of filamin is catalyzed by caspase-3 in u937 and jurkat cells. J Biochem 130: 535-542, 2001

5.Takahashi N, Sasagawa N, Usuki F, Kino Y, Kawahara H, Sorimachi H, Maeda T, Suzuki K, Ishiura S: Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS Cells. J Biochem 130: 581-587, 2001

6.Ishiura S, Hotoda N, Szabo B, Asai M, Hattori C, Tanaka E, Koike H, Sasagawa N: Alzheimer amyloid α-secretase: a special target for drug development. Psychogeriatrics 1: 273-276, 2001

7.Suo S, Sasagawa N, Ishiura S: Identification of a dopamine receptor from Caenohabditis elegans. Neurosci Lett 319: 13-16, 2002

高島明彦　（理化学研究所・脳科学総合研究センター）

1.Takashima A, Murayama M, Yasutake K, Takahashi H, Yokoyama M, Ishiguro K: Involvement of Cdk5 activator p25 on tau phophorylation in mouse brain. Neurosci Lett 306: 37-40, 2001

2.Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Frautschy SA, Takashiima A: Intracellular Aβ is increased by okadaic acid exposure in the transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2001

3.Yoshiike Y, Tanemura K, Murayama O, Akagi T, Murayama M, Sato S, Sun X, Tanaka N, Takashima A: New insights on how metals disrupt amyloid-β aggregation and their effects on amyloid-β cytotoxicity. J Biol Chem 276: 32293-32299, 2001

4.Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B: Presenilin 1 regulates beta-catenin-mediated transcription in a GSK 3β-independent fashion. J Biol Chem 276: 38563-38569, 2001

5.Murayama M, Sun X, Takashima A: Synthesis of the His6-tagged recombinant protein APP C99 His and His-PS1 using the RTS 500. Biochemica 4: 24-26, 2001

6.Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park J-M, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A: Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis 8: 1036-1045, 2001

7.Kimura N, Nakamura S, Honda T, Takashima A, Nakayama H, Ono F, Sakakibara I, Doi K, Kawamura S, Yoshikawa Y: Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain. Brain Res 922: 30-41, 2001

8.Tanemura K, Akagi T, Murayama M, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A: Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002

9.Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H, Takashima A:

10.Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 321: 61-64, 2002

西道隆臣　（理化学研究所・脳科学総合研究センター）

1.Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276: 21895-21901, 2001

2.Choi W-S, Lee E-H, Chung C-W, Jung Y-K, Jin BK, Kim SU, Oh TH, Saido TC, Oh YJ: Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: Protective role of Bcl-2. J Neurochem 77: 1531-1541, 2001

3.Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee H-J, Saido TC: Metabolic regulation of brain Aβ by neprilysin. Science 292: 1550-1552, 2001

4.Kaneko T, Yamashima T, Tohma Y, Nomura M, Imajoh-Ohmi S, Saido TC, Nakao M, Saya H, Yamamoto H, Yamashita J: Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis for tumorigenesis. Cancer 92: 2662-2672, 2001

5.Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC: Clearance of extracellular and cell-associated amyloid β peptide by viral expression of neprilysin in primary culture. J Biochem 130: 721-726, 2001

6.Russo C, Schettini G, Saido TC, Gambetti P, Tabaton M, Teller JT: N-terminally truncated amyloid β peptides and Alzheimer's disease. Neurobiol Aging 22: 345, 2001

7.Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y: Alzheimer's β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferease. Proc Natl Acad Sci USA 98: 13554-13559, 2001

8.Kim JE, Han BS, Choi WS, Eom DS, Lee EH, Oh TH, Markelonis GJ, Saido TC, Lee GE, Chung IK, Oh YJ: Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X_L. J Neurosci Res 66: 1074-1082, 2001

9.Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, St.George-Hyslop P, Saido TC: Aβ-degrading endopeptidase, neprilysin, in mouse brain: Synaptic and axonal localization inversely correlating with Aβ pathology. Neurosci Res in press

西村正樹　（滋賀医科大学・分子神経科学研究センター）

1.Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH: Nicastrin binds to membrane-tethered Notch. Nat Cell Biol 3: 751-754, 2001

2.Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P: Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP. Neurobiol Aging 23: 187-194, 2002

森　啓　（大阪市立大学・大学院医学研究科）

1.Pigino G, Pelsman A, Mori H, Busciglio J: Presenilin 1 mutations reduce cytoskeletal association, deregulate neurite growth and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21: 834-842, 2001

2.Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St, George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, and Mori H: Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22: 367-376, 2001

3.Takahashi K, Kamiya K, Urase K, Suga M, Takizawa T, Mori H, Yoshikawa Y, Ichimura K, Kuida K, Momoi T: Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res 894: 359-367, 2001

4.Park I-H, Jung MW, Mori H, Inhee M-J: Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture. Biochem Biophys Res Commun 285: 680-688, 2001

5.Kametani F, Tanaka K, Usami M, Maruyama K, Mori H: Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimer's amyloid precursor protein in PC12D cells. J Neurol Sci 188: 27-31, 2001

石井一弘　（筑波大学・臨床医学系）

1.Ishii K, Lippa CF, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St. George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H: Distinguishable effects of Presnilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22: 367-376, 2001

2.Ishii K, Tamaoka A, Shoji S: A case of primary focal lingual dystonia induced by speaking. Eur J Neurol 8: 507, 2001.

3.Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S: Moderate or high doses of prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid β peptides in CSF. Neurology in press

加藤兼房　（愛知県心身障害者コロニー・発達障害研究所）

1.Kato K, Ito H, Iwamoto I, Iida K, Inaguma Y: Protein kinase inhibitors suppress stress-induced dissociation of Hsp27. Cell Stress Chap 6: 16-20, 2001

2.Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Kato K, Uematsu T: αB-crystallin, a low molecular weight heat shock protein, acts as a regulator of platelet function. Cell Stress Chap 6: 21-28, 2001

3.Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M: Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease. Nat Genet 27: 369-370, 2001

4.Katoh-Semba R, Takeuchi I K, Inaguma Y, Ichisaka S, Hata Y, Tsumoto T, Iwai M, Mikoshiba K, Kato K: Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: Involvement of region-specific voltage-dependent calcium channels. J Neurochem 77: 71-83, 2001

5.Ito H, Kamei K, Iwamoto I, Inaguma Y, Kato K: Regulation of the levels of small heat shock proteins during differentiation of C2C12 cells. Exp Cell Res 266: 213-221, 2001

6.Kozawa O, Niwa M, Matsuno H, Ishisaki A, Kato K, Uematsu T: Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts:　 Role of protein kinase C. Arch Biochem Biophys 388: 237-242, 2001

7.Kozawa O, Otsuka T, Hatakeyama D, Niwa M, Matsuno H, Ito H, Kato K, Matsui N, Uematsu T: Mechanism of prostaglandin D₂-stimulated heat shock protein 27 induction in osteoblasts. Cell Signal 13: 535-541, 2001

8.Inaguna Y, Ito H, Iwamoto I, Saga S, Kato K: αB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis. Eur J Cell Biol 80: 741-748, 2001

9.Yamada K, Yamada Y, Nomura N, Miura K, Wakako R, Hayakawa C, Matsumoto A, Kumagai T, Yoshimura I, Miyazaki S, Kato K, Sonta S, Ono H, Yamanaka T, Nagaya M, Wakamatsu N: Nonsense and frame shift mutations in ZFHX1B, encoding smad interacting protein-1, cause a complex developmental disorder with a variety of neurocristopathies. Am J Hum Genet 69: 1178-1185, 2001

10.Asano T, Shinohara H, Morishita R, Ueda H, Kawamura N, Katoh-Semba R, Kishikawa M, Kato K: Selective localization of G protein γ₅ subunit in the subventricular zone of the lateral ventricle and rostral migratory stream of the adult rat brain. J Neurochem 79: 1129-1135, 2001

11.Ueda H, Morishita R, Itoh H, Narumiya S, Mikoshiba K, Kato K, Asano T: Gα11 induces caspace-mediated proteolytic activation of Rho-associated kinase, ROCK-1, in HeLa cells. J Biol Chem 276: 42527-42533, 2001

12.Bidmon H-J, Emde B, Kowalski T, Schmitt M, Mayer B, Kato K, Asayama K, Witte O W, Zilles K: Nitric oxide synthetase-I containing cortical interneurons co-express antioxidative enzymes and anti-apoptotic Bcl2 following focal ischemia: evidence for direct and indirect mechanisms towards their resistance to neuropathology. J Chem Neuroanat 22: 167-184, 2001

13.Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Kato K, Tatematsu N, Shibata T, Uematsu T: Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts. Am J Physiol Endocrinol Metab 281: E1260-E1266, 2001

14.Ito H, Kamei K, Iwamoto I, Inaguma Y, Galcia-Mata R, Sztul E, Kato K: Inhibition of proteasomes induces accumulation, phosphorylation and recruitment of HSP27 and αB-crystallin to aggresomes. J Biochem in press

岸田昭世　（広島大学・医学部）

1.Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi, A: Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol 21: 330-342, 2001

2.Kishida M, Hino S, Michiue T, Yamamoto H, Kishida S, Fukui A, Asashima M, Kikuchi A: Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iε. J Biol Chem 276: 33147-33155, 2001

3.Kobayashi M, Kishida S, Fukui A, Michiue T, Miyamoto Y, Okamoto T, Yoneda Y, Asashima M, Kikuchi, A: Nuclear localization of Duplin, β-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. J Biol Chem in press

三枝弘尚　（東京医科歯科大学・大学院医歯学総合研究科）

1.Kubota M, Murakoshi T, Saegusa H, Kazuno A, Zong S, Hu Q, Noda T, Tanabe T: Intact LTP and fear memory but impaired spatial memory in mice lacking Ca_v2.3 (alpha1E) channel. Biochem Biophys Res Commun 282: 242-248, 2001

2.Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T: Suppression of inflammatory and neuropathic pain symptoms in mice lacking N-type Ca²⁺ channel. EMBO J 20: 2349-2356, 2001

3.Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Analysis of Ca²⁺ currents in spermatocytes from mice lacking Ca_v2.3 (alpha1E) Ca²⁺ channel. Biochem Biophys Res Commun 288: 1032-1036, 2001

4.Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T: Mice lacking Ca_v2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun 289: 791-795, 2001

5.Toriyama H, Wang L, Saegusa H, Zong S, Osanai M, Murakoshi T, Noda T, Ohno K, Tanabe T: Role of Ca_v2.3 (alpha1E) Ca²⁺ channel in ischemic neuronal injury. NeuroReport 13: 261-265, 2002

6.Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T: Novel Ca_v2.1 splice variants isolated from Purkinje cells do not generate P-type Ca²⁺ current. J Biol Chem 277: 7214-7221, 2002

7.Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Ca_v2.3 (alpha1E) Ca²⁺ channel participates in the control of sperm function. FEBS Lett in press

鈴木利治　（北海道大学・大学院薬学研究科）

1.Satoh Y, Hirakura Y, Shibayama S, Hirashima N, Suzuki T, Kirino Y: β-amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray. Neurosci Lett 302: 97-100, 2001

2.Ando K, Iijima K, Elliott J I, Kirino Y, Suzuki T: Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid. J Biol Chem 276: 40353-40361, 2001

3.Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem in press

4.Hase M, Yagi Y, Taru H, Tomita S, Sumioka A, Hori K, Miyamoto K, Sasamura T, Nakamura M, Matsuno K, Suzuki T: Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem in press

玉岡　晃　（筑波大学・臨床医学系）

1.Ishii K, Tamaoka A, Shoji S: A case of primary focal lingual dystonia induced by speaking. Eur J Neurol 8: 507, 2001

2.Ishii K, Lippa C, TomiyamaT, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H: Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22: 367-376, 2001

3.Matsuno S, Tamaoka A, Yoshizawa K, Watanabe M, Shoji S: A case with mysthenia gravis (MG) emerging after splenectomy for idiopathic thrombocytopenic purpura (ITP): possible effects of thymectomy on autoantibodies. J Med 31: 327-332, 2001

4.Tokuda T, Tamaoka A, Matsuno S, SakuraiS, Shimada H, Morita H, Ikeda S: Plasma levels of amyloid β proteins did not differ between subjects with and without taking statins. Ann Neurol 49: 546-547, 2001

5.Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S: Moderate or high doses of prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid β peptides in CSF. Neurology in press

6.Miyawaki K, Nakamura H, Matsuno S, Tamaoka A, Doi K: Three-dimensional and fractal analysis of assemblies of amyloid β protein subtypes (Aβ40 and Aβ42(43)) in canine senile plaques. Acta Neuropathol in press

玉村啓和　（京都大学・大学院薬学研究科）

1.Otaka A, Watanabe H, Mitsuyama E, Yukimasa A, Tamamura H, Fujii N: Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of gamma,gamma-difluoro-alpha,beta-enoates. Tetrahedron Lett 42: 285-287, 2001

2.Otaka A, Watanabe H, Yukimasa A, Oishi S, Tamamura H, Fujii N: New access to alpha-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under 'reduction-oxidative alkylation (R-OA)' conditions. Tetrahedron Lett 42: 5443-5446, 2001

3.Oishi S, Tamamura H, Yamashita M, Odagaki Y, Hamanaka N, Otaka A, Fujii N: Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu. J Chem Soc, Perkin Trans 1: 2445-2451, 2001

4.Tamamura H, Hori H, Otaka A, Fujii N: Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O, N-acyl transfer reactions. J Chem Soc, Perkin Trans 1: 577-580, 2002

内木宏延　（福井医科大学・医学部）

1.Yamaguchi I, Hasegawa K, Naiki H, Mitsu T, Matuo Y, Gejyo F: Extension of Aβ2M amyloid fibrils with recombinant human β2-microglobulin. Amyloid 8: 30-40, 2001

2.Mori M, Toyokuni S, Kondo S, Kasai H, Naiki H, Toichi E, Hosokawa M, Higuchi K: Spontaneous loss-of-function mutations of the 8-oxoguanine DNA glycosylase gene in mice and exploration of the possible implication of the gene in senescence. Free Radic Biol Med 30: 1130-1136, 2001

3.Yamaguchi I, Hasegawa K, Takahashi N, Gejyo F, Naiki H: Apolipoprotein E inhibits the depolymerization of β2-microglobulin-related amyloid fibrils at a neutral pH. Biochemistry 40: 8499-8507, 2001

4.Ohhashi Y, Hagihara Y, Kozhukh GV, Hoshino M, Hasegawa K, Yamaguchi I, Naiki H, Goto Y: The intrachain disulfide bond of β2-microglobulin is inessential for the immunoglobulin fold at neutral pH but essential for amyloid fibril formation at acidic pH. J Biochem 131: 45-52, 2002

5.Kozhukh GV, Hagihara Y, Kawakami T, Hasegawa K, Naiki H, Goto Y: Investigation of a peptide responsible for amyloid fibril formation of β2-microglobulin by Acromobacter protease I. J Biol Chem 277: 1310-1315, 2002

6.Taniguchi T, Azuma H, Okada Y, Naiki H, Hollenberg MD, Muramatsu I: Endothelin-1-endothelin receptor type A mediates closure of rat ductus arteriosus at birth. J Physiol 537: 579-585, 2001

7.Hoshino M, Katou H, Nakashima Y, Hagihara Y, Hasegawa K, Naiki H, Goto Y: Mapping of the β2-microglobulin amyloid fibril core by H/D exchange monitored by NMR. Nat Struct Biol in press

8.Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H: Nordihydroguaiaretic acid potently breaks down preformed Alzheimer’s β-amyloid fibrils in vitro. J Neurochem in press

9.Martsev SP, Dubnovitsky AP, Vlasov AP, Hoshino M, Hasegawa K, Naiki H, Goto Y: Amyloid fibril formation of mouse VL domain under acidic pH. Biochemistry in press

長谷川成人　（東京都精神医学総合研究所）

1.Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49: 501-511, 2001

2.Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A: Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene. Ann Neurol 50: 117-120, 2001

3.Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309: 89-92, 2001

4.Hasegawa M, Fujiwara H, Domae N, Kawashima A, Masliah E, Goldberg S, Shen J, Takio K, Iwatsubo T: α-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4: 160-164, 2002.

5.Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol in press

早川　浩　（九州大学・大学院医学研究院）

1.Hayakawa H, Kuwano M, Sekiguchi M: Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein. Biochemistry 40: 9977-9982, 2001

針谷康夫　（群馬大学・医学部）

1.Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M: Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol 194: 500-506, 2001

2.Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S: The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently. Neurobiol Aging 22: 209-215, 2001

3.Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park J, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M: Aβ amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice. Neurosci Lett 299: 169-172, 2001

4.Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K: Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiat 70: 386-389, 2001

5.Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St. George-Hyslop P, Shoji M: Generation of amyloid β protein from a presenilin-1 and βAPP complex. Biocem Biophys Res Commun in press

6.Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia and the lack of PHF-typed, dystrophic neuritis. Virchows Archiv in press

藤野貴広　（東北大学・遺伝子実験施設）

1.Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT: Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem 276: 11420-11426, 2001

2.Ikeda Y, Yamamoto J, Okamura M, Fujino T, Takahashi S, Takeuchi K, Osborne T F, Yamamoto TT, Ito S, Sakai J: Transcriptional regulation of the murine acetyl CoA synthetase 1 gene through multiple clustered binding site for SREBPs and a single neighboring site for Sp1. J Biol Chem 276: 34259-34269, 2001

3.Fujino T, Takei Y A, Sone H, Ioka R X, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TT: Molecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. J Biol Chem 276: 35961-35966, 2001

満田憲昭　（愛媛大学・医学部）

1.Ohkubo N, Mitsuda N, Tamatani M, Yamaguchi A, Lee YD, Ogihara T, Vitek MP, Tohyama M: Apolipoprotein E4 stimulates CREB's transcriptional activity through the ERK pathway. J Biol Chem 276: 3046-3053, 2001

2.Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, Tohyama M: ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med 7: 317-323, 2001

3.Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276: 5256-5264, 2001

4.Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Ogihara T, Vitek MP, Tohyama M: Activated CREB regulates neuronal expression of presenilin-1. J Biol Chem 276: 9688-9698, 2001

5.Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15: 1218-1220, 2001

山口晴保　（群馬大学・医学部）

1.Yamaguchi H, Sugihara S, Ogawa A, Ihara Y: Alzheimer β amyloid deposition, which is hastened by ApoE ε4 gene, precedes neurofibrillary pathology in the frontal association cortex of non-demented senior subjects. J Neuropathol Exp Neurol 60: 731-739, 2001

2.Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y: Accumulation of amyloid β-protein in the low-density membrane domain accurately reflects the extent of β-amyloid deposition in the brain. Am J Pathol 158: 2209-2218, 2001

3.Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park J-M, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A: Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis 8: 1036-1045, 2001

4.Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A: Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002

5.Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy A, Takashima A: Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2002

6.Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem in press

横山信治　（名古屋市立大学・大学院医学研究科）

1.Tomimoto S, Tsujita M, Okazaki M, Usui S, Tada T, Fukutomi T, Ito S, Itoh M, Yokoyama S: Effect of probucol in lecithin-cholesterol acyltransferase deficient mice: Inhibition of two independent cellular cholesterol releasing pathways in vivo. Arterioscler Thromb Vasc Biol 21: 394-400, 2001

2.Goto A, Sasai K, Suzuki S, Fukutomi T, Ito S, Matsushita T, Okamoto M, Suzuki T, Itoh M, Okuyama-Noji K, Yokoyama S: Cholesteryl ester transfer protein and atherosclerosis in Japanese subjects: A study based on coronary angiography. Atheroscelrosis 159: 153-163, 2001

3.Kojima K, Abe-Dohmae S, Arakawa R, Murakami I, Suzumori K, Yokoyama S: Progesterone Inhibits Apolipoprotein-mediated cellular lipid release: A putative mechanism for the decrease of HDL. Biochim Biophys Acta 1532: 173-184, 2001

4.Tanaka AR, Ikeda Y, Abe-Dohmae S, Arakawa R, Sadanami K, Kidera A, Nakagawa S, Nagase T, Aoki R, Kioka N, Amachi T, Yokoyama S, Ueda K: Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome. Biochem Biophys Res Commun 283: 1019-1025, 2001

5.Okumura-Noji K, Sasai K, Zhan R, Kawaguchi H, Maruyama H, Tada T, Takahashi H, Okazaki M, Miida T, Sakuma N, Kimura G, Ohta N, Yokoyama S: Cholesteryl ester transfer protein-deficiency causes slow egg embryonation of Schistosoma japonicum. Biochem Biophys Res Commun 286: 305 -310, 2001

6.Li Q, Yokoyama S, Agellon LB: Active taurocholic acid flux through hepatoma cells increases the cellular pool of unesterified cholesterol derived from lipoproteins. Biochim Biophys Acta in press

7.Ito J, Nagayasu Y, Kato K, Sato R, Yokoyama S: Apolipoprotein A-I induces translocation of cholesterol, phospholipid and caveolin-1 to cytosol in rat astrocytes. J Biol Chem in press

8.Ueno S, Ito J, Nagayasu Y, Furukawa T, Yokoyama S: An acidic fibroblast growth factor-like factor secreted into the brain cell culture medium upregulates ApoE synthesis, HDL secretion and cholesterol metabolism in rat astrocytes. Biochim Biopys Acta in press

和栗　聡　（大阪大学・大学院医学系研究科）

1.Waguri S, Kohmura M, Kanamori S, Watanabe T, Ohsawa Y, Koike M, Tomiyama Y, Wakasugi M, Kominami E, Uchiyama Y: Different distribution patterns of the two mannose 6-phosphate receptors in rat liver. J Histochem Cytochem 49: 1397-1405, 2001

2.Shibata M, Koike M, Waguri S, Zhang G, Koga T, Uchiyama Y: Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS Lett in press