業績集

平成12年度～平成16年度
  　 　 　 　
A01班
A02班
A03班
A04班
B01班
B02班
B03班
ゲノム班
A01班
桝　正幸　（筑波大学・基礎医学系）
  1. Tominaga M, Wada M, Masu M: Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci USA 98: 6951-6956, 2001


  2. Ohto T, Uchida H, Yamazaki H, Keino-Masu K, Matsui A, Masu M: Identification of a novel non-lysosomal sulphatase expressed in the floor plate, choroid plexus and cartilage. Genes Cells 7: 173-186, 2002


  3. Tsukada S, Keino-Masu K, Masu M, Fukuda J: Activation of protein kinase A by nitric oxide in cultured dorsal root ganglion neurites of the rat, examined by a fluorescence probe, ARII. Neurosci Lett 318: 17-20, 2002


  4. Sato H, Tamba M, Okuno S, Sato K, Keino-Masu K, Masu M, Bannai S: Distribution of cystine/glutamate exchange transporter, system x(c)-, in the mouse brain. J Neurosci 22: 8028-8033, 2002


  5. Shiomi K, Uchida H, Keino-Masu K, Masu M: Ccd1, a novel protein with a DIX domain, is a positive regulator in the Wnt signaling during zebrafish neural patterning. Curr Biol 13: 73-77, 2003


  6. Sumazaki R, Shiojiri N, Isoyama S, Masu M, Keino-Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A: Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet 36: 83-87, 2004


  7. Shiomi K, Kanemoto M, Keino-Masu K, Yoshida S, Soma K, Masu M: Identification and differential expression of multiple isoforms of mouse Ccd1 (Coiled-coil-DIX1), a positive regulator of Wnt signaling. Mol Brain Res 135: 169-180, 2005


岡野　栄之　（慶應義塾大学・医学部）
  1. Taguchi A, Sawamoto K, Okano H: Mutations modulating Argos-regulated signaling pathway during Drosophila eye development. Genetics 154: 1639-1648, 2000


  2. Araki T, Shibata M, Takano R, Hisahara S, Sugiyama F, Yagami K, Imamura S, Fukuuchi Y, Saruta T, Okano H, Miura M: Conditional expression of anti-apoptotic protein p35 by Cre-mediated DNA recombination in cells from p35 transgenic mice. Cell Death Differ 7: 485-492, 2000


  3. Takano R, Hisahara S, Mamikawa K, Kiyama H, Okano H. Miura M: Nerve growth factor protects TNF-α induced oligodendrocytes injury through PI3-kinase/Akt-mediated signaling mechanisms. J Biol Chem 275: 16360-16365, 2000


  4. Sawa H, Kouike H, Okano H: Components of the SWI/SNF complex are required for asymmetric cell division in C. elegans. Mol Cell 6: 617-624, 2000


  5. Shibata M, Hisahara S, Hara H, Yamawaki T, Fukuuchi Y, Yuan J, Okano H, Miura M: Caspase determines the vulnerability of oligodendrocytes in cerebral white matter in ischemia. J Clin Invest 106: 643-653, 2000


  6. Nguyen T.Q, Sawa H, Okano H, White JG: The C. elegans septin genes, unc-59 and unc-61, are required for normal postembryonic cytokineses and morphogenesis but have no essential function in embryogenesis. J Cell Sci 113: 3825-3837, 2000


  7. Yoda A, Sawa H, Okano H: MSI-1, a neural RNA-binding protein, is involved in the male mating behavior in Caenorhabditis elegans. Genes Cells 5: 885-895, 2000


  8. Toda M, Iizuka Y, Yu W-J, Ikeda E, Yoshida K, Imai T, Kawase T, Kawakami Y, Okano H, Uyemura K: Expression of the neural RNA-binding protein Musashi1 in human gliomas. Glia 34: 1-7, 2001


  9. Mori H, Sakakibara, S, Imai T, Nakamura Y, Iijima T, Suzuki A, Yuasa Y, Takeda M, Okano H: Expression of mouse igf2 mRNA-binding protein 3 and its implication in the developing central nervous system. J Neurosci Res 64: 132-143, 2001


  10. Murata T, Nagaso H, Watanabe S, Okano H, Yokoyama K: The hiiragi gene encodes a poly(A) polymerase, which controls the formation of the wing margin in Drosophila melanogaster. Dev Biol 233: 137-147, 2001


  11. Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H: Translational repression determines a neuronal potential in Drosophila asymmetric cell division. Nature 411: 94-98, 2001


  12. Sawamoto K, Yamamoto A, Kawaguchi A, Yamaguchi M, Mori K, Goldman S.A, Okano H: Visualization and direct isolation of neuronal progenitor cells by dual-color flow cytometric detection of fluorescent proteins. J Neurosci Res 65: 220-227, 2001


  13. Sawamoto K, Nakao N, Kakishita K, Ogawa Y, Toyama Y, Yamamoto A, Yamaguchi M, Mori K, Goldman SA, Itakura T, Okano H: Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J Neurosci 21: 3895-3903, 2001


  14. Imai T, Tokunaga A, Yoshida T, Hashimoto M, Weinmaster G, Mikoshiba K, Nakafuk M, Okano H: The neural RNA-binding protein Musashi1 translationally regulaties the mammalian numb gene expression by interacting with its mRNA. Mol Cell Biol 21: 3888-3900, 2001


  15. Sawamoto K, Nakao N, Kobayashi K, Matsushita N, Takahashi H, Kakishita K, Yamamoto A, Yoshizaki T, Terashima T, Murakami F, Itakura T, Okano H: Visualization and direct isolation of midbrain dopaminergic neurons expressing GFP. Proc Natl Acad Sci USA 98: 6423-6428, 2001


  16. Uchida M, Hanai S, Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K: Genetic and functional analysis of PARP, a DNA strand break-binding enzyme. Mutat Res 47: 89-96, 2001


  17. Ishida Y, Nakamoto H, Imai H, Suzuki S, Okano H, Suzuki H: Heme oxygenase-1 regulates vascular tone of the peritoneum undergoing peritoneal dialysis. Adv Perit Dial 17: 15-19, 2001


  18. Li R-Y, Baba S, Kosugi I, Arai Y, Kawasaki H, Shinmura Y, Sakakibara S, Okano H, Tsusui Y: Activation of murine cytomegalovirus immediate-early promoter in cerebral ventricular zone and glial progenitor cells in transgenic mice. Glia 35: 41-52, 2001


  19. Yagita Y, Kitagawa K, Otsuki T, Kuwabara K, Mabuchi T, Miyata T, Okano H, Hori M, Matsumoto M: Neurogenesis by progenitor cells in the ischemic adult rat hippocampus. Stroke 32: 1890-1896, 2001


  20. Miyata T, Kawaguchi A, Okano H, Ogawa M: Asymmetric inheritance of radial glial fibers to neurons during corticogensis in mice. Neuron 31: 727-741, 2001


  21. Kohyama J, Abe H, Shimazaki T, Koizumi A, Nakashim K, Taga T, Okano H, Hata J, Umezawa A: Brain from bone: efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agen. Differentiation 68: 235-244, 2001


  22. Keyoung HM, Roy NS, Benraiss A, Louissaint AJr, Suzuki A, Hashimoto K, Rashbaum WK, Okano H, Goldman SA: Prospective identification, selection and extraction of two distinct pools of neural stem cells from fetal human brain. Nat Biotech 19: 843-850, 2001


  23. Kanemura Y, Mori K, Sakakibara S, Ohnishi T, Fujikawa H, Hayashi H, Matsumoto T, Imai T, Ohnishi T, Fushiki S, Nakamura Y, Yamasaki M, Okano H, Arita N: Musashi1, an evolutionarily conserved neural RNA-binding protein is a versatile marker of human glioma cells in determining their cellluar origin, malignancy and proliferative activity. Differentiation 68: 141-152, 2001


  24. Sakakibara S, Nakamura Y, Satoh H, Okano H: RNA-binding protein Musashi2: developmentally regulated expression in neural precursor cells and subpopulation of neurons in mammalian CNS. J Neurosci 21: 8091-8107, 2001


  25. Yamamoto N, Matsunaga E, Yamamoto S, Kobayashi D, Torii M, Kawaichi M, Kishi N, Matsuno K, Okano H,  Nakafuku M: Deltex as a nuclear signal transducer downstream of the Notch receptor. J Biol Chem 276: 45031-45940, 2001


  26. Saunders PTK, Maguire SM, Macpherson S, Fenelon MC, Sakakibara S, Okano H: The RNA binding protein Musashi1 (Msi1) is expressed in the cytoplasm and nucleus of Sertoli cells in the rat testis from fetal life to adulthood. Biol Reprod 66: 500-507, 2002


  27. Uchida M, Hanai S, Uematsu N, Sawamoto K, Okano H, Miwa M, Uchida K: Overexpression of poly(ADP-ribose) polymerase disrupts organization of cytoskeletal F-actin and tissue polarity in Drosophila. J Biol Chem 277: 6696-6702, 2002


  28. Matsuno K, Ito M, Hori K, Miyashita F, Suzuki S, Kishi N, Artravanis-Tsakonas S, Okano H: Involvement of a proline-rich motif and a RING-H2 finger in a function of Deltex as a regulator of Notch signaling. Development 129: 1049-1059, 2002


  29. Takasawa K-I, Kitagawa K, Yagita Y., Sasaki T, Tanaka S, Ohtsuki T, Miyata T, Okano H, Hori M, Matsumoto M: Increased proliferation of neural progenitor cells but reduced survival newborn cells in the contralateral hippocampus after focal cerebral ischemia in rats. J Cereb Blood Flow Metab 22: 299-307, 2002


  30. Iwai Y, Hirota Y, Ozaki K, Okano H, Takeichi M, Uemura T: DN-cadherin-dependent synaptogenesis in the Drosophila visual system. Mol Cell Neurosci 19: 375-388, 2002


  31. Shibata M, Yamawaki T, Sasaki T, Hattori H, Hamada J, Fukuuchi Y, Okano H, Miura M: Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res 942: 1-10, 2002


  32. Shu H-J, Saito T, Watanabe H, Ito J-I, Takeda H, Okano H, Kawata S: Expression of the Musashi1 gene encoding the RNA-binding protein in human hepatoma cell lines. Biochem Biophys Res Commun 293: 150-154, 2002


  33. Cuadrado A, Garcia-Fernandez LF, Imai T, Okano H, Munoz A: Neural RNA-binding protein Musashi-1 modulates tau pre-mRNA alternative splicing and is regulated by thyroid hormone in the developing rat brain. Mol Cell Neurosci 20: 198-210, 2002


  34. Shamloula HK, Mbogho MP, Pimentel AC, Chrzanowska-Lightowlers ZMA, Hyatt V, Okano H, Venkatech TR: rugose (rg), a Drosophila A kinase anchor protein (DAKAP), is required for required for retinal pattern formation and interacts genetically with multiple signaling pathways. Genetics 161: 693-710, 2002


  35. Yagita Y, Kitagawa K, Sasaki T, Miyata T, Okano H, Hori T, Matsumoto M: Differential expression of Musashi1 and nestin in the adult rat hippocampus after ischemia. J Neurosci Res 69: 750-756, 2002


  36. Ogawa Y, Sawamoto K, Miyata T, Miyao S, Watanabe M, Toyama Y, Nakamura M, Bregman BS, Koike M, Uchiyama Y, Okano H: Transplantation of in vitro expanded fetal neural progenitor cells results in neurogenesis and functional recovery after spinal cord contusion injury in adult rats. J Neurosci Res 69: 925-933, 2002


  37. Murayama A, Matsuzaki Y, Kawaguti A, Shimazaki T, Okano H: Flow cytometric analysis of stem cells in the developing and adult mouse brain. J Neurosci Res 69: 837-847, 2002


  38. Johansson CB, Lothian C, Molin M, Okano H, Lendahl U: Nestin enhancer requirements for expression in normal and injured adult CNS. J Neurosci Res 69: 784-794, 2002


  39. Kanemura Y, Mori H, Kobayashi, S, Islam O, Kodama E, Yamamoto A, Nakanishi Y, Arita N, Yamasaki M, Okano H, Miyake J, Hara M: Evaluation of in-vitro proliferative activity of human fetal neural stem cell. J Neurosci Res 69: 869-879, 2002


  40. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M: Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol 4: 705-710, 2002


  41. Sakakibara S, Nakamura Y, Koike M, Takano H, Uchiyama Y, Noda T, Okano H: RNA-binding protein Musashi family, roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation. Proc Natl Acad Sci USA 99: 15194-15199, 2002


  42. Hirota Y, Sawamoto K, Okano H: tincar encodes a novel transmembrane protein expressed in the Tinman-expressing cardioblasts of Drosophila. Mech Dev 119S: 271-275, 2002


  43. Tonchev A.B, Yamashima T, Zhao L, Okano H: Differential proliferative response in the postischemic hippocampus, temporal cortex and olfactory bulb of adult primates. Glia 42: 209-224, 2003


  44. Tonchev AB, Yamashima T, Zhao L, Okano HJ, Okano, H: Proliferation of neural and neuronal progenitors after global brain ischemia in young adult macaque monkeys. Mol Cell Neurosci 23: 292-301, 2003


  45. Kuo H-C, Pau FKY, Yeoman RR, Mitalipov SM, Okano H, Wolf DP: Differentiation of monkey embryonic stem cells into neural lineages. Biol Reprod 68: 1727-1735, 2003


  46. Kayahara T, Sawada M, Takaishi S, Fukui H, Seno H, Fukuzawa H, Suzuki K, Hiai H, Kageyama, R, Okano H, Chiba T: Candidate markers for stem and early progenitor cells, Musashi-1 and Hes1, are expressed in crypt base columnar cells of mouse small intestine. FEBS Lett 535: 131-135, 2003


  47. Sasaki T, Kitagawa K, Sugimura S, Omura-Matsuoka E, Tanaka S, Yagita Y, Okano H, Matsumoto M, Hori M: Implication of cyclooxygenase-2 on enhanced proliferation of neural progenitor cells in the adult mouse hippocampus after ischemia. J Neurosci Res 72: 461-471, 2003


  48. Nakamura Y, Yamamoto M, Oda E, Yamamoto A, Kanemura Y, Hara M, Suzuki A, Yamasaki M, Okano H: Expression of tubulin beta II in neural stem/progenitor cells and radial fibers during human fetal brain development. Lab Invest 83: 479-489, 2003


  49. Yuasa Y, Okabe M, Yoshikawa S, Tabuchi K, Xiong W-C, Hiromi Y, Okano H: Drosophila homeodomain protein REPO controls glial differentiation by cooperating with ETS and BTB transcription factors. Development 130: 2419-2428, 2003


  50. Uchida K, Okano H, Hayashi T, Mine Y, Tanioka Y, Nomura T, Kawase T: Grafted swine neuroepithelial stem cells can form myelinated axons and both efferent and afferent synapses with xenogeneic rat neurons. J Neurosci Res 72: 661-669, 2003


  51. Kokuzawa J, Yoshimura S, Kitajima H, Shinoda J, Kaku Y, Iwama T, Morishita R, Shimazaki T, Okano H, Kunisada T, Sakai N: Hepatocyte growth factor promotes proliferation and neural differentiation of neural stem cells from mouse embryos. Mol Cell Neurosci 24: 190-197, 2003


  52. Ishizuya-Oka A, Shimizu K, Sakakibara S.I, Okano H, Ueda S: Thyroid hormone-upregulated expression of Musashi-1 is specific for progenitor cells of the adult epithelium during amphibian gastrointestinal remodeling. J Cell Sci 116: 3157-3164, 2003


  53. Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M: Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila. Proc Natl Acad Sci USA 100: 11723-11728, 2003


  54. Baker H, Kobayashi K, Okano H, Saino-Saito S: Cortical and striatal expression of tyrosine hydroxylase mRNA in neonatal and adult mice. Cell Mol Neurobiol 23: 503-518, 2003


  55. Tamaki T, Akatsuka A, Okada Y, Matsuzaki Y, Okano H, Kimura M: Growth and differentiation potential of main- and side-population cells derived from murine skeletal muscle. Exp Cell Res 291: 83-90, 2003


  56. Miyanomori Y, Kobayashi H, Imai T, Watanabe M, Nagata T, Uesugi S, Okano H, Katahira M: Origin of figher affinity to RNA of the N-terminal RNA-binding domain than that of the C-terminal one of a mouse neural protein, musashi1, as revealed by comparison of their structures, modes of interaction, surface electrostatic potentials, and backbone dynamics. J Biol Chem 278: 41309-41315, 2003


  57. Yoshida T, Tokunaga A, Nakao K, Okano H: Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas. Differentiation 71: 486-495, 2003


  58. Hu QD, Ang BT, Karsak M, Hu WP, Cui XY, Duka T, Takeda Y, Chia W, Natesan S, Ng YK, Ling EA, Israel A, Maciag T, Small D, Trifonova R, Kopan R, Okano H, Nakafuku M, Chiba S, Hirai H, Schachner M, Pallen CJ, Watanabe K, Xiao ZC: F3/Contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell 115: 163-175, 2003


  59. Murata J, Murayama A, Horii A, Doi K, Harada T, Okano H, Kubo T: Expression of Musashi1, a neural RNA-binding protein, in the cochler of young adult mice. Neurosci Lett 354: 201-204, 2004


  60. Matsuzaki Y, Kinjo K, Mulligan RC, Okano H: Unexpectedly efficient homing capacity of purified murine hematopoietic stem cell. Immunity 20: 87-93, 2004


  61. Ieda M, Fukuda K, Kimura K, Hisaka Y, Kawaguchi H, Shimoda K, Takeshita E, Okano H, Kurihara Y, Kurihara H, Ishida J, Fukamiz. A, Salamone L, Howard JF, Ogawa S: Endothelin-1 regulates cardiac sympathetic nerve innervation in the rodent hearty by controlling nerve growth factor expression. J Clin Invest 113: 876-884, 2004


  62. Okada S, Nakamura M, Mikami Y, Shimazaki T, Mihara M, Ohsugi Y, Iwamoto Y, Yoshizaki K, Kishimoto T, Toyama Y, Okano H: Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury. J Neurosci Res 76: 265-76, 2004


  63. Yamashima T, Tonchev BA, Seki T, Sawamoto K, Okano H: Vascular adventitia generates neuronal progenitors in monkey hippocampus after ischemia. Hippocampus 14: 861-875, 2004


  64. Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, Darnell RB, Okano HJ, Okano H: Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett 358: 157-60, 2004


  65. Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M: Implantation of dendritic cells leading to de novo neurogenesis and functional recovery. J Neurosci Res 76: 453-465, 2004


  66. Ohba H, Chiyoda T, Endo E, Yano M, Hayakawa Y, Sakaguchi M, Darnell RB, Okano HJ, Okano H: Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett 358: 157-160, 2004


  67. Mikami Y, Okano H, Sakaguchi M, Nakamura M, Shimazaki T, Okano HJ, Kawakami Y, Toyama Y, Toda M: Implantation of dendritic cells leading to de novo neurogenesis and functional recovery. J Neurosci Res 76: 453-465, 2004


  68. Ozawa Y, Nakao K, Shimazaki T, Takeda J, Akira S, Ishihara K, Hirano T, Oguchi Y, Okano H: Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina. Mol Cell Neurosci 26: 258-270, 2004


  69. Sakaguchi H, Yaoi T, Suzuki T, Okano H, Hisa Y, Fushiki N: Spatiotemporal patterns of Musashi1 expression during inner ear development. NeuroReport 15: 997-1001, 2004


  70. Tokunaga A, Kohyama J, Yoshida T, Nakao K, Sawamoto K, Okano H: Mapping spatio-temporal activation of Notch signaling during neurogenesis and gliogenesis in the developing mouse brain. J Neurochem 90: 142-154, 2004


  71. Yoshizaki T, Inaji M, Kouike H, Shimazaki T, Sawamoto K, Ando K, Date I,Kobayashi K, Suhara T, Uchiyama Y, Okano H: Isolation and transplantation of dopaminergic neurons generated from mouse embryonic stem cells. Neurosci Lett 363: 33-37, 2004


  72. Sakuragawa N, Kakinuma K, Hatada S, Kikuchi A, Okano H, Uchida S, Kamo I, Yokoyama Y: Human amnion mesenchyme cells express phenotype of neuronal progenitor cells. J Neurosci Res 78: 208-214, 2004


  73. Ishibashi S, Sakaguchi M, Kuroiwa T, Shimazaki T, Okano H, Mizusawa H: Human neural stem/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils. J Neurosci Res 78: 215-223, 2004


  74. Uchida K, Mukai M, Okano H, Hayashi T, Kawase T: Possible origin of the astroblastoma: A novel concept based on experimental findings from clinical material and a review of the literature. Neurosurgery 55: 977-978, 2004


  75. Unezaki S, Nishizawa M, Okuda-Ashitaka E, Masu Y, Mukai M, Kobayashi S, Sawamoto K, Okano H, Ito S: Characterization of isoforms of MOVO zinc finger protein, a mouse homologue of Drosophila Ovo, as transcription factor. Gene 336: 47-58, 2004


  76. Kawada H, Fujita J, Kinjo k, Matsuzaki Y, Tsuma M, Miyatake H, Muguruma Y, Itabashi Y, Ikeda Y, Ogawa S, Okano H, Hotta T, Ando K, Fukuda K: Non-hematopoietic mesenchymal stem cells can be mobilized and differentiate into cardiomyocytes after myocardial infarction. Blood 104: 3581-3587, 2004


  77. Okada Y, Shimazaki T, Sobue G, Okano H: Retinoic acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells. Dev Biol 275: 124-142, 2004


  78. Kawaguchi A, Ogawa M, Saito K, Matsuzaki F, Okano H, Miyata: Differential expression of Pax6 and Ngn2 between pair-generated cortical neurons. J Neurosci Res 78: 784-795, 2004


  79. Hori K, Ito M, Fuwa TJ, Okano H, Baron M, Matsuno K: Deltex induces an accumulation of the vesicular Notch protein and activates suppressor of hairless-independent Notch signaling in Drosophila. Development 131: 5527-37, 2004


  80. Watanabe K, Nakamura M, Iwanami A, Fujita Y, Kanemura Y, Toyama Y, Okano H: Comparison between fetal spinal cord-and forebrain-derived neural stem/progenitor cells as a source of transplantation for spinal cord injury. Dev Neurosci 26: 275-287, 2004


  81. Clarke RB, Spence K, Anderson E, Howell A, Okano H, Potten CS: A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev Biol 277: 443-456, 2005


  82. Sakaguchi M, Sawamoto K, Shimazaki T, Kitamura T, Shibuya A, Okano H: A method for gene transfer, single isolation and in vitro assay for neural stem cells. Inflamm Regen 25: 50-54, 2005


  83. Uemura O, Okada Y, Ando H, Guedj M, Higashijima S, Shimazaki T, Chino N, Okano H, Okamoto H: Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor neuron and sensory neuron-specific expression. Dev Biol 278: 587-606, 2005


  84. Hishikawa K, Marummo T, Miura S, Nakanishi A, Matsuzaki Y, Shibata K, Kohike H, Komori T, Hayashi M, Nakaki T, Nakauchi H, Okano H, Fujita T: Leukemia inhibitory factor induces multi-lineage differentiation of adult stem-like cells in kidney via kidney-specific cadherin 16. Biochem Biophys Res Commun 328: 288-291, 2005


  85. Suzuki K, Fukui H, Kayahara T, Sawada M, Seno H, Hiai H, Kageyama R, Okano H, Chiba T: Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. Biochem Biophys Res Commun 328: 348-352, 2005


  86. Kitagawa A, Nakayama T, Takenaga M, Matsumoto K, Tokura Y, Ohta Y, Ichinohe M, Yamaguchi Y, Suzuki N, Okano H, Igarashi R: Lecithinized brain-derived neurotrophic factor promotes the differentiation of embryonic stem cells in vitro and in vivo. Biochem Biophys Res Commun 328: 1051-1057, 2005


  87. Hirota Y, Takahashi K, Ueda R, Okano H: Transmembrane protein Tincar is expressed and involved in the development of Drosophila photoreceptor cells. Dev Genes Evol 215: 90-96, 2005


  88. Iwanami A, Yamane J, Katoh H, Nakamura M, Momomoshima S, Ishii H, Tanioka Y, Tamaoki N, Nomura T, Toyama Y, Okano H: Establishment of graded spinal cord injury model in a non-human primate: the common marmoset. J Neurosci Res 80: 172-181, 2005


  89. Iwanami A, Kaneko S, Nakamura M, Kanemura Y, Mori H, Kobayashi S, Yamasaki M, Momoshima S, Ishii H, Ando K, Tanioka Y, Tamaoki N, Nomura T, Toyama Y, Okano H: Transplantation of human neural stem/progenitor cells promotes functional recovery after spinal cord injury in common marmoset. J Neurosci Res 80: 182-190, 2005


  90. Akamatsu W, Fujiwara H, Mitsuhashi T, Yano M, Shibata S, Hayakawa Y, Okano HJ, Sakakibara S, Takano H, Takano T, Takahashi T, Noda T, Okano H: RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci USA 102：4625-4630, 2005


  91. Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, Witzel SB, Okano H, Ko, MSH, Ohlsson R, Longo DL, Feinberg AP: Loss of imprinting of IgfII alter intestinal maturation and tumorigenesis in mice. Science 307: 1976-1978, 2005


  92. Yoda A, Kouike H, Okano H, Sawa H: Components of the transcriptional mediator complex are required for asymmetric cell division in C. elegans. Development 132: 1885-1893, 2005


  93. Nakamura Y, Yamamoto M, Miyado K, Okano HJ, Fukagawa R, Higaki K, Yamasaki M, Okano H: A novel marker for Purkinje cells, KIAA0864 protein. An analysis based on a monoclonal antibody HFB-16 in developing human cerebellum. J Histochem Cytochem 53: 423-430, 2005


  94. Nagato M, Heike T, Kato T, Yamanaka Y, Yoshimoto M, Shimazaki T, Okano H, Nakahata T: Prospective characterization of neural stem cells by flow cytometry analysis using combination of the surface markers. J Neurosci Res 80: 456-466, 2005


  95. Islam MO, Kanemura Y, Tajria J, Mori H, Kobayashi S, Hara M, Yamasaki M, Okano H, Miyake J: Functional expression of ABCG2 transporter in human neural stem/progenitor cells. Neurosci Res 52: 75-82, 2005


  96. Tamura M, Nakamura M, Ogawa Y, Toyama Y, Miura M, Okano H: Targeted expression of anti-apoptotic protein, p35, in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury. Glia 51: 312-321, 2005


  97. Pignatelli A, Kobayashi K, Okano H, Belluzzi O: Functional responses of dopaminergic neurons in the mouse olfactory bulb. J Physiol 564: 501-514, 2005


  98. Uchida K, Momiyama T, Okano H, Yuzaki M, Koizumi A, Mine Y, Kawase T: Potential functional neural repair with grafted neural stem cells of early embryonic neuroepithelial origin. Neurosci Res 53: 276-286, 2005


  99. Yuasa S, Itabashi Y, Koshimizu U, Tanaka T, Sugimura K, Fukami S, Itabashi Y, Hattori F, Shinazaki T, Ogawa S, Okano H and Fukuda K: Transient inhibition of BMP signaling by Noggin induces cardiomyocyte differentiation of mouse embryonic stem cells. Nat Biotech 23: 607-611, 2005


  100. Kambara H, Okano H, Chiocca A, Saeki Y: An oncolytic HSV1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals, even when symptomatic from a brain tumor. Cancer Res 65: 2832-2839, 2005


  101. Jomphe C, Bourque MJ, Fortin GD, St-Gelais F, Okano H, Kobayashi K, Trudeau LE: Use of TH-EGFP transgenic mice as a source of identified dopaminergic neurons for physiological studies in postnatal cell culture. J Neurosci Methods 146: 1-12, 2005


  102. Matsumoto T, Okamoto R, Yajima T, Mori T, Okamoto S, Ikeda Y, Mukai M, Yamazaki M, Oshima S, Tsuchiya K, Nakamura T, Kanai T, Okano H, Inazawa J, Hibi T, Watanabe M: Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 128: 1851-1867, 2005


  103. Matsuda Y, Wakamatsu Y, Kohyama J, Okano H, Fukuda K, Yasugi S: Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. Development 132: 2783-2793, 2005


  104. Akasaka Y, Saikawa Y, Fujita K, Kubota T, Ishii T, Okano H, Kitajima M: Expression of a candidate marker for progenitor cells, Musashi-1, in the proliferative regions of human antrum and its decreased expression in intestinal metaplasia. Histopathology 47: 348-356, 2005


  105. Crespel A, Rigau V, Coubes P, Rousset MC, de Bock F, Okano H, Baldy-Moulinier M, Bockaert J, Lerner-Natoli M: Increased neurogenesis in human temporal lobe epilepsy: evidence for a new neurogenis area, the fissura hippocampi. Neurobiol Dis 19: 436-450, 2005


  106. Sasaki T, Iwata S, Okano HJ, Urasaki Y, Hamada J, Tanaka H, Dang NH, Okano H, Morimoto C: Nedd9 protein, a Cas-L homologue, is upregulated and may remodel neurons after transient global ischemia. Stroke 36: 2457-2462,2005


  107. Yamashita T, Sawamoto K, Suzuki S, Suzuki N, Adachi K, Kawase T, Mihara M, Ohsugi Y, Abe K, Okano H: Blockade of IL-6 signaling aggravates ischemic cerebral damage in mice. J Neurochem 94: 459-468, 2005


  108. Yoshimi K, Ren Y-R, Seki T, Yamada M, Hayakawa H, Ooizumi H, Onodera M, Saito Y, Maruyama S, Okano H, Mizuno Y, Mochizuki H: Possibility of neurogenesis in substantia nigra of parkinsonian brain. Ann Neurol 58: 31-40, 2005


  109. Mori A, Ueda T, Shimizu H, Yoshitake A, Hachiya T, Onoguchi K, Takakura H, Yoshitake M, Taguchi S, Cho Y, Inoue S, Kabei N, Okano H, Yozu R, Sasaki T: An epidural cooing catheter protects the spinal cord against ischemic injury in pigs. Ann Thorac Surg 80:1829-1833,2005


  110. Islam MO, Kanemura Y, Tajria J, Mori H, Kobayashi S, Miyake J, Hara M, Yamasaki M, Okano H: Characterization of ABC transporter, ABCB1 expressed in human neural stem/progenitor cells. FEBS Lett 579: 3473-3480, 2005


  111. Sasaki E, Hanazawa K, Kurita R, Akatsuka A, Yoshizaki T, Ishii H, Tanioka Y, Ohnishi Y, Suemizu H, Sugawara A, Tamaoki N, Izawa K, Nakazaki Y, Hamada H, Suemori H, Nakatsuji N, Okano H, Tani K: Establishment of novel embryonic stem cell lines derived from the common marmoset (Callithrix jacchus). Stem Cells 23: 1304-1313, 2005


  112. Nakamura M, Okano H, Toyama Y, Dai HN, Bregman BS: Transplantation of embryonic spinal cord-derived neural stem cells support growth of suprapinal projections and functional recovery after spinal cord injury in naonate rat. J Neurosci Res 81: 457-468, 2005


  113. Hishikawa K, Miura S, Nakanishi A, Shibata K, Matsuzaki Y, Marumo T, Hayashi M, Nakaki T, Okano H, Fujita T: Musculin/MyoR is expressed in kidney side population cells and can regulate their function. J Cell Biol 169: 921-928, 2005


  114. Sahara M, Sata M, Matsuzaki Y, Tanaka K, Morita T, Hirata Y, Okano H, Nagai R: Comparison of various bone marrow fractions in the ability to participate in vascular remodeling after mechanical injury. Stem Cells 23: 874-878, 2005


  115. Tonchev AB, Yamashima T, Sawamoto K, Okano H: Enhanced proliferation of progenitor cells in the subventricular zone and limited neuronal production in the striatum and neocortex of adult macaque monkeys after global cerebral ischemia. J Neurosci Res 81: 776-788, 2005


  116. Suzuki S, Yamashita T, Tanaka K, Hattori H, Sawamoto K, Okano H, Suzuki N: Activation of cytokine signaling through leukemia inhibitory factor receptor (LIFR)/gp130 attenuates ischemic brain injury in rats. J Cereb Blood Flow Metab 25: 685-693, 2005


  117. Kanemura Y, Mori H, Nakagawa A, Islam MO. Kodama E, Yamamoto A, Shofuda T, Kobayashi S, Miyake J, Yamazaki T, Hirano S, Yamasaki M, Okano H: In vitro screening of epigenetic factors for human neural stem/progenitor cells proliferation using indirect measurement of total ATP content in viable cells. Cell Transplantation in press


中福　雅人　（東京大学・大学院医学系研究科）
  1. Takebayashi H, Yoshida S, Kominami R, Nakafuku M, Nabeshima Y: Dynamic expression of basic helix-loop-helix Olig family members: implication of Olig2 in neuron and oligodendrocyte differentiation and identification of a new member, Olig3. Mech Dev 99: 143-148, 2000


  2. Imai1T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H: The neural RNA-binding protein Musashi1 translationally regulates the m-numb gene expression by interacting with its mRNA. Mol Cell Biol 21: 3888-3900, 2001


  3. Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci USA 98: 5868-5873, 2001


  4. Mizuguchi R, Sugimori M, Takebayashi H, Kosako H, Nagao M, Yoshida S, Nabeshima Y, Shimamura K, Nakafuku M: Combinatorial roles of Olig2 and Neurogenin2 in the coordinated induction of pan-neuronal and subtype-specific properties of motoneurons. Neuron 31: 757-771, 2001


  5. Yamamoto S, Yamamoto N, Kitamura T, Nakamura K, Nakafuku M: Proliferation of parenchymal neural progenitors in response to injury in the adult rat spinal cord. Exp Neurol 172: 115-127, 2001


  6. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M: Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor. J Biol Chem 276: 45031-45040. 2001


  7. Yamamoto S, NagaoM, Sugimori M, Kosako H, Nakatomi H, Yamamoto N, Takebayashi H, Nabeshima Y, Kitamura T, Weinmaster G, NakamuraK, Nakafuku M: Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord. J Neurosci 21: 9814-9823, 2001


  8. Kato M, Seki N, Sugano S, Hashimoto K, Masuho Y, Muramatsu M, Kaibuchi K, NakafukuM: Identification of sonic hedgehog-responsive genes by using cDNA microarray. Biochem Biophys Res Commun 289: 472-478, 2001


  9. Kobayashi D, Kobayashi M, Ogura T, Nakafuku, M, Shimamura K: Early subdivisions in the neural plate define distinct competence for inductive signals. Development 129: 83-93, 2002


  10. Fu H, Qi Y, Tan M, Cai J, Takebayashi H, Nakafuku M, Richardson W, Qiu M: Dual origin of spinal oligodendrocyte progenitors and evidence for the cooperative role of Olig2 and Nkx2.2 in the control of oligodendrocyte differentiation. Development 129: 681-693, 2002


  11. HeinsN, Malatesta P, CecconiF, NakafukuM, Tucker KL, HackMA, ChapoutonP, BardeY-A, Götz M: Glial cells generate neurons: The role of the transcription factor Pax6. Nat Neurosci 5: 308-315, 2002


  12. Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M:  Regeneration of hippocampal pyramidal neurons after ischemic brain injury by recruitment of endogenous neural progenitors. Cell 110: 429-441, 2002


  13. Kamimori K, Machide M, Tomita K, Nakafuku M, Kohsaka S: Cell-type specific expression f protein tyrosine kinase- related receptor RYK in the central nervous system of the rat. Mol Brain Res 104: 255-267, 2002


有賀　純　（理化学研究所）
  1. Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K: Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci USA 97: 1618-1623, 2000


  2. Aruga J, Shimoda K, Mikoshiba K: A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord. Mol Brain Res 78: 15-25, 2000


  3. Kitaguchi T, Nagai T, Nakata K, Aruga J, Mikoshiba K: Zic3 is involved in the left-right asymmetry as a left signal mediator in Xenopus embryo. Development 127: 4787-4795 ,2000


  4. Nakata K, Koyabu Y, Aruga J, Mikoshiba K: A novel member of Xenopus Zic family, Zic5, specifically mediates neural crest development. Mech Dev 99: 83-91, 2000


  5. Tamura T, Hashimoto M, Aruga J, Konishi Y, Nakagawa M, Ohbayashi T, Shimada M, Mikoshiba K: Promoter structure and gene expression of the mouse inositol 1,4,5-trisphosphate receptor type 3 gene. Gene 275: 169-176, 2001


  6. Salero E, Perez-Sen R, Aruga J, Gimenez C, Zafra F: Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. J Biol Chem 276: 1881-1888, 2001


  7. Mizugishi K, Aruga J, Nakata K, Mikoshiba K: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 276: 2180-2188, 2001


  8. Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K: Physical and functional interaction between Zic and Gli proteins. J Biol Chem 276: 6889-6892, 2001


  9. Kitaguchi T, Nakata K, Nagai T, Aruga J, Mikoshiba K: Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev Genes Evol 211: 309-314, 2001


  10. Ogura H, Aruga J, Mikoshiba K: Behavioral abnormalities of Zic1 and Zic2 mutant mice: implications as models for human neurological disorders. Behav Genet 31: 317-324, 2001


  11. Maeda R, Mood K, Jones TL, Aruga J, Buchberg AM, Daar IO: Xmeis1, a protooncogene involved in specifying neural crest cell fate in Xenopus embryos. Oncogene 20: 1329-1342, 2001


  12. Kitaguchi T, Mizugishi K, Hatayama M, Aruga J, Mikoshiba K: Xenopus Brachyury regulates mesodermal expression of Zic3, a gene controlling left-right asymmetry. Dev Growth Differ 44: 55-61, 2002


  13. Aruga J, Inoue T, Hoshino J, Mikoshiba K: Zic2 controls the cerebellar development in cooperation with Zic1. J Neurosci 22: 218-225, 2002


  14. Aruga J, Tohmonda T, Homma S, Mikoshiba K: Zic1 promotes the expansion of dorsal neural progenitors in spinal cord by inhibiting neuronal differentiation. Dev Biol 244: 329-341, 2002


  15. Aruga J: Slitrk6 expression profile in the mouse embryo and its relationship to that of Nlrr3. Gene Expr Patterns 3: 727-733, 2003


  16. Aruga J, Yokota N, Mikoshiba K: Human SLITRK family genes, genomic organization and expression profiling in normal brain and brain tumor tissue. Gene 315: 87-94, 2003


  17. Aruga J, Mikoshiba K: Identification and characterization of Slitrk, a novel neruonal transmembrane protein family controlling neurite outgrowth. Mol Cell Neurosci 24: 117-129, 2003


  18. Herrera E, Brown L, Aruga J, Rachel RA, Dolen G, Mikoshiba K, Brown S, Mason CA: Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell 114: 545-557, 2003


  19. Hoshino J, Aruga J, Ishiguro A, Mikoshiba K: Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse. Mol Brain Res 120: 57-64, 2003


  20. Inoue T, Hatayama M, Tohmonda T, Itohara S, Aruga J, Mikoshiba K: Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives. Dev Biol 270: 146-62, 2004


  21. Mizugishi K, Hatayama M, Tohmonda T, Ogawa M, Inoue T, Mikoshiba K, Aruga J: Myogenic repressor I-mfa interferes with the function of Zic family proteins. Biochem Biophys Res Commun 320: 233-240, 2004


  22. Aruga J, Ogura H, Shutoh F, Ogawa M, Franke B, Nagao S, Mikoshiba K: Locomotor and oculomotor impairment associated with cerebellar dysgenesis in Zic3-deficient (Bent-tail) mutant mice. Eur J Neurosci 20: 2159-2167, 2004


  23. Ishiguro A, Inoue T, Mikoshiba K, Aruga J: Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Biochem Biophys Res Commun 324: 302-307, 2004


五十嵐　道弘　（新潟大学・大学院医歯学総合研究科）
  1. Ohyama A, Komiya Y, Igarashi M: Globular tail of myosin-V is bound to VAMP. Biochem Biophys Res Commun 280: 988-991, 2001


  2. Nagashima K, Torii S, Yi Z, Igarashi M, Okamoto K, Takeuchi T, Izumi T: Melanophilin directly links rab27a and myosin Va. FEBS Lett 517: 233-238, 2002


  3. Ohyama A, Hosaka K, Komiya Y, Akagawa K, Yamauchi E, Taniguchi H, Sasakawa, N, Kumakura K, Mochida S, Yamauchi T, Igarashi M:Regulation of exocytosis through Ca2+/ATP-dependent binding of autophosphorylated CaMKII to syntaxin 1A. J Neurosci 22: 3342-3351, 2002


  4. Togano T, Kurachi M, Watanabe M, Grenningloh G, Igarashi M: Role of Ser50 phosphorylation in SCG10 regulation of microtubule depolymerization. J Neurosci Res 80: 475-480, 2005


  5. Watanabe M, Nomura K, Ohyama A, Ishikawa R, Komiya Y, Hosaka K, Yamauchi E, Taniguchi H, Sasakawa N, Kumakura K, Ushiki T, Sato O, Ikebe M, Igarashi M: Myosin-Va regulates exocytosis through Ca2+-dependent binding of syntaxin-1A. Mol Biol Cell 16: 4519-4530, 2005


石川　良樹　（群馬大学・医学部）
  1. Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, Kohama K, Shimizu H, Tano Y, Shimada S: Retinal fascin: Functional nature, subcellular distribution, and choromosomal localization. Invest Ophthalmol Vis Sci 41: 2087-2095, 2000


  2. Samizo K, Ishikawa R, Nakamura A, Kohama K: A highly sensitive method for measurement of myosin ATPase activity by reversed-phase high-performance liquid chromatography. Anal Biochem 293: 212-215, 2001


  3. Ishikawa R, Sakamoto T, Ando T, Higashi-Fujime S, Kohama K: Polarized actin bundle formed by human fascin-1: Their sliding and disassembly on myosin II and myosin V in vitro. J Neurochem 87: 676-685, 2003


  4. Katoh K, Yoshida F, Ishikawa R: Actin dynamics in neuronal growth cone revealed with a polarized light microscopy. Adv Exp Med Biol 538: 347-358, 2003


  5. Takahashi I, Akaishi E, Abe Y, Ishikawa R, Tanaka S, Hosaka K, Kubohara Y: Zinc inhibits calcineurin activity in vitro by competing with nickel. Biochem Biophys Res Commun 307: 64-68, 2003


  6. Shimizu K, Murata T, Tagawa T, Takahashi K, Ishikawa R, Abe Y, Hosaka K, Kubohara Y: Calmodulin-dependent cyclic nucleotide phosphodiesterase (PDE1) is a pharmacological target of differentiation-inducing factor-1, an antitumor agent isolated from Dictyostelium. Cancer Res 64: 2568-2571, 2004


石橋　誠　（京都大学・大学院医学研究科）
  1. Ishibashi M, McMahon AP: A Sonic hedgehog-dependent signaling relay regulates growth of diencephalic and mesencephalic primordia in the early mouse embryo. Development 129: 4807-4819, 2002


  2. Saitsu H, Ishibashi M, Nakano H, Shiota K: Spatial and temporal expression of Folate-binding protein 1 (Fbp1) is closely associated with anterior neural tube closure in mice. Dev Dyn 226: 112-117, 2003


  3. Saitsu H, Yamada S, Uwabe C, Ishibashi M, Shiota K: Development of the posterior neural tube in human embryos. Anat Embryol 209: 107-117, 2004


  4. Saitsu H, Komada M, Suzuki M, Nakayama R, Motoyama J, Shiota K, Ishibashi M: Expression of the mouse Fgf15 gene is directly initiated by sonic hedgehog signaling in the diencephalon and midbrain. Dev Dyn 232: 282-292, 2004


  5. Ishibashi M, Saitsu H, Komada M, Shiota K: Signaling cascade coordinating growth of dorsal and ventral tissues of the vertebrate brain, with special reference to: the involvement of sonic hedgehog signaling. Anat Sci Int 80: 30-36, 2005


  6. Okano J, Takigawa T, Seki K, Suzuki S, Shiota K, Ishibashi M: Transformation growth factor β-2 promotes the formation of the mouse cochleovestibular ganglion in organ culture. Int J Dev Biol 48: 23-31, 2005


市川　量一　（札幌医科大学・医学部）
  1. Shibata T, Watanabe M, Ichikawa R, Ameda K, Koyanagi T: Transient neonatal expression of NR2B/2D subunit mRNAs of the parasympathetic preganglionic neurons in the rat spinal cord. Dev Brain Res 140: 263-268, 2003


井上　芳郎　（北海道大学・大学院医学研究科）
  1. Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, Sanbo M, Yagi T, Inoue Y, Nabeshima T, Mori H, Mishina M: Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci 13: 179-189, 2001


  2. Hashimoto K, Ichikawa R, Takechi H, Inoue Y, Aiba A, Sakimura K, Mishina M, Hashikawa T, Konnerth A, Watanabe M, Kano M: Roles of glutamate receptor δ2 subunit (GluRδ2) and metabotropic glutamate receptor subtype 1 (mGluR1) in climbing fiber synapse elimination during postnatal cerebellar development. J Neurosci 21: 9701-9712, 2001


  3. Fujikawa K, Inoue Y, Sakai M, Koyama Y, Nishi S, Funada R, Alt FW, Swat W: Vav3 is regulated during the cell cycle and effects cell division. Proc Natl Acad Sci USA 99: 4313-4318, 2002


  4. Ding L, Yamada K, Takayama C, Inoue Y: Development of astrocytes in the lamina cribrosa sclerae of the mouse optic nerve, with special reference to myelin formation. Okajimas Folia Anat Jpn 79: 143-158, 2002


  5. Ichikawa R, Miyazaki T, Kano M, Hashikawa T, Tatsumi H, Sakimura K, Mishina M, Inoue Y, Watanabe M: Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor delta 2. J Neurosci 22: 8487-8503, 2002


大隅　典子　（東北大学・大学院医学系研究科・附属創生応用医学研究センター）
  1. Kasai K, Takahashi M, Osumi N, Sinnarajah S, Takeo T, Ikeda H, Kehrl JH, Itoh G, Arnheiter H: The G12 family of heterotrimeric G proteins and Rho GTPase mediate sonic hedgehog signaling. Genes Cells 9: 49-58, 2004


  2. Wakamatsu Y, Endo Y, Osumi N, Weston JA: Multiple roles of SOX2, a HMG-box transcription factor in avian neural crest development. Dev Dyn 229: 74-86, 2004


  3. Nomura T, Osumi N: Misrouting of mitral cells in Pax6/Small eye rat telencephalon. Development 131: 787-796, 2004


  4. Wakamatsu Y, Osumi N, Weston JA: Expression of a novel secreted factor, Seraf, indicates an early segregation of Schwann cell precursors from neural crest during avian development. Dev Biol 268: 162-173. 2004


  5. Kobayashi K, Takahashi M, Matsushita N, Jiyazaki J, Koike M, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi K: Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci 24: 3480-3488, 2004


  6. Takahashi M, Osumi N: Identification of a novel type II classical cadherin: Rat cadherin19 is expressed in the cranial ganglia and Schwann cell precursors during development. Dev Dyn 232: 200-208, 2005


  7. Nagase T, Nagase M, Osumi N, Fukuda S, Nakamura S, Ohsaki K, Harii K, Asato H, Yoshimura K: Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly. J Craniofac Surg 16: 80-88, 2005


  8. Kohwi M, Osumi N, Rubenstein JLR, Alvarez-Buylla A: Pax6 is required for making specific subpopulations of granule and periglomerular neurons in the olfactory bulb. J Neurosci 25: 6997-7003, 2005


小椋　利彦　（東北大学・加齢医学研究所）
  1. Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini A, Matsuda Y, Ogura T: Cloning and chromosomal mapping of human and chicken iroquois (Irx) genes. Cytogenet Cell Genet 92: 320-325, 2001


  2. Kobayashi D, Kobayashi M, Matsumoto K, Ogura T, Nakafuku M, Shimamura K: Early subdivisions in the neural plate define distinct competence for inductive signals. Development 129: 83-93, 2002


  3. Nishihara S, Tsuda L, Ogura T: The canonical Wnt pathway directly regulates NRSF/REST expression in chick spinal cord. Biochem Biophys Res Commun 311: 55-63, 2003


  4. Matsumoto K, Nishihara S, Kamimura M, Otoguro T, Uehara M, Maeda Y, Ogura K, Lumsden A, Ogura T: The Iroquois prepattern gene Irx2 induces the complete transformation of tectum to cerebellum. Nat Neurosci 7: 605-612, 2004


  5. Kamimura M, Matsumoto K, Koshiba-Takeuchi K, Ogura T: Vertebrate Crossveinless 2 is secreted and acts as a modulator of the BMP signaling cascade, Dev Dyn 230: 434-445, 2004


  6. Kida Y, Shiraishi T, Ogura T: Identification of chick and mouse Daam1 and Daam2 genes and their expression patterns in the central nervous system. Dev Brain Res 153: 143-150, 2004


  7. Azuma N, Tadokoro K, Asaka A, Yamada M, Yamaguchi Y, Handa H, Matsushima S, Watanabe T, Kohsaka S, Kida Y, Shiraishi T, Ogura T, Shimamura K, Nakafuku M: The Pax6 isoform bearing an alternative spliced exon promotes the development of the neural retinal structure. Hum Mol Genet 14: 735-745, 2005


  8. Azuma N, Tadokoro K, Asaka A, Yamada M, Yamaguchi Y, Handa H, Matsushima S, Watanabe T, Kida Y, Ogura T, Shimamura K, Nakafuku M: Transdifferentiation of the retinal pigment epithelia to the neural retina by transfer of the Pax6 transcriptional factor. Hum Mol Genet 14: 1059-1068, 2005


貝淵　弘三　（名古屋大学・大学院医学系研究科）
  1. Szaszi K, Kurashima K, Kapus A, Paulsen A, Kaibuchi K, Grinstein S, Orlowski J: RhoA and rho kinase regulate the epithelial Na+/H+ exchanger NHE3. Role of myosin light chain phosphorylation. J Biol Chem 275: 28599-28606, 2000


  2. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C: Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168, 2000


  3. Shimizu T, Ihara K, Maesaki R, Kuroda S, Kaibuchi K, Hakoshima T: An open conformation of switch I revealed by the crystal structure of a Mg2+-free form of RHOA complexed with GDP. Implications for the GDP/GTP exchange mechanism. J Biol Chem 275: 18311-18317, 2000


  4. Sato M, Tani E, Fujikawa H, Kaibuchi K: Involvement of Rho-kinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 87: 195-200, 2000


  5. Royal I, Lamarche-Vane N, Lamorte L, Kaibuchi K, Park M: Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol Biol Cell 11: 1709-1725, 2000


  6. Oude Weernink PA, Schulte P, Guo Y, Wetzel J, Amano M, Kaibuchi K, Haverland S, Voss M, Schmidt M, Mayr GW, Jakobs KH: Stimulation of phosphatidylinositol-4-phosphate 5-kinase by Rho-kinase. J Biol Chem 275: 10168-10174, 2000


  7. Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura Y, Leung T, Lim L, Kaibuchi K: Phosphorylation of ERM proteins at filopodia induced by Cdc42. Genes Cells 5: 571-581, 2000


  8. Miyata K, Shimokawa H, Kandabashi T, Higo T, Morishige K, Eto Y, Egashira, K, Kaibuchi K, Takeshita A: Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo. Arterioscler Thromb Vasc Biol 20: 2351-2358, 2000


  9. Miyamoto S, Baba H, Kuroda S, Kaibuchi K, Fukuda T, Maehara Y, Saito T: Changes in E-cadherin associated with cytoplasmic molecules in well and poorly differentiated endometrial cancer. Br J Cancer 83: 1168-1175, 2000


  10. Kawajiri A, Itoh N, Fukata M, Nakagawa M, Yamaga M, Iwamatsu A, Kaibuchi K: Identification of a novel beta-catenin-interacting protein. Biochem Biophys Res Commun 273: 712-717, 2000


  11. Kaneko T, Amano M, Maeda A, Goto H, Takahashi K, Ito M, Kaibuchi K: Identification of calponin as a novel substrate of Rho-kinase. Biochem Biophys Res Commun 273: 110-116, 2000


  12. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A: Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta. Circulation 101: 1319-1323, 2000


  13. Kanai-Azuma M, Mattick JS, Kaibuchi K, Wood SA: Co-localization of FAM and AF-6, the mammalian homologues of drosophila faf and canoe, in mouse eye development. Mech Dev 91: 383-386, 2000


  14. Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K: Elongation factor-1 alpha is a novel substrate of rho-associated kinase. Biochem Biophys Res Commun 278: 72-78, 2000


  15. Inagaki N, Nishizawa M, Arimura N, Yamamoto H, Takeuchi Y, Miyamoto E, Kaibuchi K, Inagaki M: Activation of Ca2+/calmodulin-dependent protein kinase II within post-synaptic dendritic spines of cultured hippocampal neurons. J Biol Chem 275: 27165-27171, 2000


  16. Ihara K, Shimizu T, Maesaki R, Okada, K, Amano M, Kaibuchi K, Hakoshima T: Crystallization and preliminary crystallographic analysis of the rho-binding domain of bovine rho-kinase. Acta Crystallogr D Biol Crystallogr 56: 1042-1044, 2000


  17. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Tamura K, Goto T, Aimoto S, Kaibuchi K, Shiosaka S, Takeda M: Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase II in the apical dendrites during long-term potentiation. J Neurochem 75: 373-382, 2000


  18. Hamaguchi T, Ito M, Feng J, Seko T, Koyama M, Machida H, Takase K, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T: Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N. Biochem Biophys Res Commun 274: 825-830, 2000


  19. Eto Y, Shimokawa H, Hiroki J, Morishige K, Kandabashi T, Matsumoto Y, Amano M, Hoshijima M, Kaibuchi K, Takeshita A: Gene transfer of dominant negative Rho kinase suppresses neointimal formation after balloon injury in pigs. Am J Physiol Heart Circ Physiol 278: H1744-H1750, 2000


  20. Arimura N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu A, Goshima Y, Kaibuchi K: Phosphorylation of collapsin response mediator protein-2 by Rho-kinase: Evidence for two separate signaling pathways for growth cone collapse. J Biol Chem 275: 23973-23980, 2000


  21. Amano M, Fukata Y, Kaibuchi K: Regulation and functions of Rho-associated kinase. Exp Cell Res 261: 44-51, 2000


  22. Zong H, Kaibuchi K, Quilliam LA: The insert region of RhoA is essential for Rho kinase activation and cellular transformation. Mol Cell Biol 21: 5287-5298, 2001


  23. Taya S, Inagaki N, Sengiku H, Makino H, Iwamatsu A, Urakawa I, Nagao K, Kataoka S, Kaibuchi K: Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J Cell Biol 155: 809-820, 2001


  24. Szaszi K, Kurashima K, Kaibuchi K, Grinstein S, Orlowski J: Role of the cytoskeleton in mediating cAMP-dependent protein kinase inhibition of the epithelial Na+/H+ exchanger NHE3. J Biol Chem 276: 40761-40768, 2001


  25. Sugimoto N, Imoto I, Fukuda Y, Kurihara N, Kuroda S, Tanigami A, Kaibuchi K, Kamiyama R, Inazawa J: IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A. J Hum Genet 46: 21-25, 2001


  26. Shimokawa H, Morishige K, Miyata K, Kandabashi T, Eto Y, Ikegaki I, Asano T, Kaibuchi K, Takeshita A: Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo. Cardiovasc Res 51: 169-177, 2001


  27. Shibata R, Kai H, Seki Y, Kato S, Morimatsu M, Kaibuchi K, Imaizumi T: Role of Rho-associated kinase in neointima formation after vascular injury. Circulation 103: 284-289, 2001


  28. Shah V, Bharadwaj S, Kaibuchi K, Prasad GL: Cytoskeletal organization in tropomyosin-mediated reversion of ras-transformation: Evidence for Rho kinase pathway. Oncogene 20: 2112-2121, 2001


  29. Sato M, Tani E, Fujikawa H, Yamaura I, Arita N, Kaibuchi K: Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm. Acta Neurochir Suppl 77: 49-54, 2001


  30. Pantaleon M, Kanai-Azuma M, Mattick JS, Kaibuchi K, Kaye PL, Wood SA: FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development. Mech Dev 109: 151-160, 2001


  31. Ohnaka K, Shimoda S, Nawata H, Shimokawa H, Kaibuchi K, Iwamoto Y, Takayanagi R: Pitavastatin enhanced bmp-2 and osteocalcin expression by inhibition of rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun 287: 337-342, 2001


  32. Nakagawa M, Fukata M, Yamaga M, Itoh N, Kaibuchi K: Recruitment and activation of Rac1 by the formation of E-cadherin-mediated cell-cell adhesion sites. J Cell Sci 114: 1829-1838, 2001


  33. Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, Kaibuchi K, Takeshita A: Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension. FASEB J 15: 1062-1064, 2001


  34. Morishige K, Shimokawa H, Eto Y, Hoshijima M, Kaibuchi K, Takeshita A: In vivo gene transfer of dominant-negative rho-kinase induces regression of coronary arteriosclerosis in pigs. Ann NY Acad Sci 947: 407-411, 2001


  35. Morishige K, Shimokawa H, Eto Y, Kandabashi T, Miyata K, Matsumoto Y, Hoshijima M, Kaibuchi K, Takeshita A: Adenovirus-mediated transfer of dominant-negative rho-kinase induces a regression of coronary arteriosclerosis in pigs in vivo. Arterioscler Thromb Vasc Biol 21: 548-554, 2001


  36. Katoh K, Kano Y, Amano M, Onishi H, Kaibuchi K, Fujiwara K: Rho-kinase-mediated contraction of isolated stress fibers. J Cell Biol 153: 569-584, 2001


  37. Katoh K, Kano Y, Amano M, Kaibuchi K, Fujiwara K: Stress fiber organization regulated by MLCK and Rho-kinase in cultured human fibroblasts. Am J Physiol Cell Physiol 280: C1669-C1679, 2001


  38. Kato M, Seki N, Sugano S, Hashimoto K, Masuho Y, Muramatsu MA, Kaibuchi K, Nakafuku M: Identification of sonic hedgehog-responsive genes using cDNA microarray. Biochem Biophys Res Commun 289: 472-478, 2001


  39. Inagaki N, Chihara K, Arimura N, Menager C, Kawano Y, Matsuo N, Nishimura T, Amano M, Kaibuchi K: CRMP-2 induces axons in cultured hippocampal neurons. Nat Neurosci 4: 781-782, 2001


  40. Funakoshi Y, Ichiki T, Shimokawa H, Egashira K, Takeda K, Kaibuchi K, Takeya M, Yoshimura T, Takeshita A: Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells. Hypertension 38: 100-104, 2001


  41. Fukata M, Nakagawa M, Itoh N, Kawajiri A, Yamaga M, Kuroda S, Kaibuchi K: Involvement of IQGAP1, an effector of Rac1 and Cdc42 GTPases, in cell-cell dissociation during cell scattering. Mol Cell Biol 21: 2165-2183, 2001


  42. Delon J, Kaibuchi K, Germain RN: Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 15: 691-701, 2001


  43. Araki S, Ito M, Kureishi Y, Feng J, Machida H, Isaka N, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T: Arachidonic acid-induced Ca2+ sensitization of smooth muscle contraction through activation of Rho-kinase. Pflugers Arch 441: 596-603, 2001


  44. Tsuboi D, Qadota H, Kasuya K, Amano M, Kaibuchi K: Isolation of the interacting molecules with GEX-3 by a novel functional screening. Biochem Biophys Res Commun 292: 697-701, 2002


  45. Soto MC, Qadota H, Kasuya K, Inoue M, Tsuboi D, Mello CC, Kaibuchi K: The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegans. Genes Dev 16: 620-632, 2002


  46. Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z: Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol 22: 8467-8477, 2002


  47. Maeda A, Amano M, Fukata Y, Kaibuchi K: Translocation of Na(+), K(+)-ATPase is induced by Rho small GTPase in renal epithelial cells. Biochem Biophys Res Commun 297: 1231-1237, 2002


  48. Kataoka C, Egashira K, Inoue S, Takemoto M, Ni W, Koyanagi M, Kitamoto S, Usui M, Kaibuchi K, Shimokawa H, Takeshita A: Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats. Hypertension 39: 245-250, 2002


  49. Kandabashi T, Shimokawa H, Mukai Y, Matoba T, Kunihiro I, Morikawa K, Ito M, Takahashi S, Kaibuchi K, Takeshita A: Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries. Arterioscler Thromb Vasc Biol 22: 243-248, 2002


  50. Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K: Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 109: 873-885, 2002


  51. Fukata Y, Itoh TJ, Kimura T, Menager C, Nishimura T, Shiromizu T, Watanabe H, Inagaki N, Iwamatsu A, Hotani H, Kaibuchi K: CRMP-2 binds to tubulin heterodimers to promote microtubule assembly. Nat Cell Biol 4: 583-591, 2002


  52. Fukata Y, Kimura T, Kaibuchi K: Axon specification in hippocampal neurons. Neurosci Res 43: 305-315, 2002


  53. Tharaux PL, Bukoski RC, Rocha PN, Crowley SD, Ruiz P, Nataraj C, Howell DN, Kaibuchi K, Spurney RF, Coffman TM: Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. JImmunol 171: 96-105, 2003


  54. Suzuki Y, Nakagomi S, Namikawa K, Kiryu-Seo S, Inagaki N, Kaibuchi K, Aizawa H, Kikuchi K, Kiyama H: Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. J Neurochem 86: 1042-1050, 2003


  55. Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N: AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1. J Biol Chem 278: 15232-15238, 2003


  56. Shimizu T, Ihara K, Maesaki R, Amano M, Kaibuchi K, Hakoshima T: Parallel coiled-coil association of the RhoA-binding domain in Rho-kinase. J Biol Chem 278: 46046-46051, 2003


  57. Nishimura T, Fukata Y, Kato K, Yamaguchi T, Matsuura Y, Kamiguchi H, Kaibuchi K: CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth. Nat Cell Biol 5: 819-826, 2003


  58. Ito K, Hirooka Y, Sakai K, Kishi T, Kaibuchi K, Shimokawa H, Takeshita A: Rho/Rho-kinase pathway in brain stem contributes to blood pressure regulation via sympathetic nervous system: possible involvement in neural mechanisms of hypertension. Circ Res 92: 1337-1343, 2003


  59. Genth H, Gerhard R, Maeda A, Amano M, Kaibuchi K, Aktories K, Just I: Entrapment of Rho ADP-ribosylated by Clostridium botulinum C3 exoenzyme in the Rho-guanine nucleotide dissociation inhibitor-1 complex. J Biol Chem 278: 28523-28527, 2003


  60. Becknell B, Shen T, Maghraby E, Taya S, Kaibuchi K, Caligiuri MA, Marcucci G: Characterization of leukemia-associated Rho guanine nucleotide exchange factor (LARG) expression during murine development. Cell Tissue Res 314: 361-366, 2003


  61. Amano M, Kaneko T, Maeda A, Nakayama M, Ito M, Yamauchi T, Goto H, Fukata Y, Oshiro N, Shinohara A, Iwamatsu A, Kaibuchi K: Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase. J Neurochem 87: 780-790, 2003


  62. Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K: Interaction with IQGAP1 Links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 7: 871-883, 2004


  63. Takami A, Iwakubo M, Okada Y, Kawata T, Odai H, Takahashi N, Shindo K, Kimura K, Tagami Y, Miyake M, Fukushima K, Inagaki M, Amano M, Kaibuchi K, Iijima H: Design and synthesis of Rho kinase inhibitors (I). Bioorg Med Chem 12: 2115-2137, 2004


  64. Sato T, Kanai Y, Noma T, Kanai-Azuma M, Taya S, Matsui T, Ishii M, Kawakami H, Kurohmaru M, Kaibuchi K, Wood SA, Hayashi Y: A close correlation in the expression patterns of Af-6 and Usp9x in Sertoli and granulosa cells of mouse testis and ovary. Reproduction 128: 583-594, 2004


  65. Ren XD, Wang R, Li Q, Kahek LA, Kaibuchi K, Clark RA: Disruption of Rho signal transduction upon cell detachment. J Cell Sci 117: 3511-3518, 2004


  66. Noritake J, Fukata M, Sato K, Nakagawa M, Watanabe T, Izumi N, Wang S, Fukata Y, Kaibuchi K: Positive role of IQGAP1, an effector of Rac1, in actin-meshwork formation at sites of cell-cell contact. Mol Biol Cell 15: 1065-1076, 2004


  67. Nishimura T, Kato , Yamaguchi T, Fukata Y, Ohno S, Kaibuchi K: Role of the PAR-3-KIF3 complex in the establishment of neuronal polarity. Nat Cell Biol 6: 328-334, 2004


  68. Nakaya Y, Kuroda S, Katagiri YT, Kaibuchi K, Takahashi Y: Mesenchymal-epithelial transition during somitic segmentation is regulated by differential roles of Cdc42 and Rac1. Dev Cell 7: 425-438, 2004


  69. Moriki N, Ito M, Seko T, Kureishi Y, Okamoto R, Nakakuki T, Kongo M, Isaka N, Kaibuchi K, Nakano T: RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats. Hypertens Res 27: 263-270, 2004


  70. Menager C, Arimura N, Fukata Y, Kaibuchi K: PIP3 is involved in neuronal polarization and axon formation. J Neurochem 89: 109-118, 2004


  71. Kobayashi K, Takahashi M, Matsushita N, Miyazaki J, Koike M, Yaginuma H, Osumi N, Kaibuchi K: Survival of developing motor neurons mediated by Rho GTPase signaling pathway through Rho-kinase. J Neurosci 24: 3480-3488, 2004


  72. Kawabata S, Usukura J, Morone N, Ito M, Iwamatsu A, Kaibuchi K, Amano M: Interaction of Rho-kinase with myosin II at stress fibres. Genes Cells 9: 653-660, 2004


  73. Ito K, Hirooka Y, Sagara Y, Kimura Y, Kaibuchi K, Shimokawa H, Takeshita A, Sunagawa K: Inhibition of Rho-kinase in the brainstem augments baroreflex control of heart rate in rats. Hypertension 44: 478-483, 2004


  74. Ito K, Hirooka Y, Kishi T, Kimura Y, Kaibuchi K, Shimokawa H, Takeshita A: Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition. Hypertension 43: 156-162, 2004


  75. Hiroki J, Shimokawa H, Higashi M, Morikawa K, Kandabashi T, Kawamura N, Kubota T, Ichiki T, Amano M, Kaibuchi K, Takeshita A: Inflammatory stimuli upregulate Rho-kinase in human coronary vascular smooth muscle cells. J Mol Cell Cardiol 37: 537-546, 2004


  76. Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Tsutsui H, Kaibuchi K, Takeshita A: Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. Circulation 109: 2234-2239, 2004


  77. Hattori T, Shimokawa H, Higashi M, Hiroki J, Mukai Y, Kaibuchi K, Takeshita A: Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. Circ Res 94: 46-52, 2004


  78. Birukova AA, Birukov KG, Smurova K, Adyshev D, Kaibuchi K, Alieva I, Garcia JG, Verin AD: Novel role of microtubules in thrombin-induced endothelial barrier dysfunction. FASEB J 18: 1879-1890, 2004


  79. Birukova AA, Smurova K, Birukov KG, Usatyuk P, Liu F, Kaibuchi K, Ricks-Cord A, Natarajan V, Alieva I, Garcia JG, Verin AD: Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 201: 55-70, 2004


  80. Birukova AA, Smurova K, Birukov KG, Kaibuchi K, Garcia JG, Verin AD: Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 67: 64-77, 2004


  81. Abe K, Shimokawa H, Morikawa, K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshita A: Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 94: 385-393, 2004


  82. Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K: GSK-3β regulates phosphorylation of CRMP-2 and neuronal polarity. Cell 120: 137-149, 2005


  83. Xu J, Taya S, Kaibuchi K, Arnold AP: Spatially and temporally specific expression in mouse hippocampus of Usp9x, a ubiquitin-specific protease involved in synaptic development. J Neurosci Res 80: 47-55, 2005


  84. Noritake J, Watanabe T, Sato K, Wang S, Kaibuchi K: IQGAP1: a key regulator of adhesion and migration. J Cell Sci 118: 2085-2092, 2005


  85. Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima YI, Ohno S, Hoshino M, Kaibuchi K: PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1. Nat Cell Biol 7: 270-277, 2005


  86. Nakayama M, Amano M, Katsumi A, Kaneko T, Kawabata S, Takefuji M, Kaibuchi K: Rho-kinase and myosin II activities are required for cell type and environment specific migration. Genes Cells 10: 107-117, 2005


  87. Kimura T, Arimura N, Fukata Y, Watanabe H, Iwamatsu A, Kaibuchi K: Tubulin and CRMP-2 complex is transported via kinesin-1. J Neurochem 93: 1371-1382, 2005


  88. Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA: Integrin activation and matrix binding mediate cellular responses to mechanical stretch. J Biol Chem 280: 16546-16549, 2005


  89. Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C: Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival. J Neurosci 25: 1459-1469, 2005


  90. Abe K, Morikawa K, Hizume T, Uwatoku T, Oi K, Seto M, Ikegaki I, Asano T, Kaibuchi K, Shimokawa H: Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension. J Cardiovasc Pharmacol 45: 120-124, 2005


鹿川　哲史　（岡崎共同研究機構・生理学研究所）
  1. Wada T, Kagawa T, Ivanova A, Zalc B, Shirasaki R, Murakami F, Iemura S, Ueno N, Ikenaka K: Dorsal spinal cord inhibits oligodendrocyte development. Dev Biol 227: 42-55, 2000


  2. Moran-Rivard L, Kagawa T, Saueressig H, Gross MK, Burrill J, Goulding M: Evx1 is a postmitotic determinant of v0 interneuron identity in the spinal cord. Neuron 29: 385-399, 2001


  3. Ono K, Kagawa T, Tsumori T, Yokota S, Yasui Y: Morphological changes and cellular dynamics of oligodendrocyte lineage cells in the developing vertebrate central nervous system. Dev Neurosci 23: 346-355, 2001


  4. Ishibashi T, Ikenaka K, Shimizu T, Kagawa T, Baba H: Initiation of sodium channel clustering at the node of Ranvier in the mouse optic nerve. Neurochem Res 28: 117-125, 2003


影山　龍一郎　（京都大学・ウイルス研究所）
  1. Sumazaki R, Shiojiri N, Isoyama S, Masu M, Masu K, Osawa M, Nakauchi H, Kageyama R, Matsui A: Conversion of biliary system to pancreatic tissue in Hes1-deficient mice. Nat Genet 36: 83-87, 2004


  2. Tsunematsu R, Nakayama K, Oike Y, Nishiyama M, Ishida N, Hatakeyama S, Bessho Y, Kageyama R, Suda T, Nakayama KI: Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem 279: 9417-9423, 2004


  3. Takatsuka K, Hatakeyama J, Bessho Y, Kageyama R: Roles of the bHLH gene Hes1 in retinal morphogenesis. Brain Res 1004: 148-155, 2004


  4. Miyoshi G, Bessho Y, Yamada S, Kageyama R: Identification of a novel bHLH gene, Heslike, and its role in GABAergic neurogenesis. J Neurosci 24: 3672-3682, 2004


  5. Kano H, Arakawa Y, Takahashi JA, Nozaki K, Kawabata Y, Takatsuka K, Kageyama R, Ueba T, Hashimoto N: Overexpression of RFT induces G1-S arrest and apoptosis via p53/p21Waf1 pathway in glioma cell. Biochem Biophys Res Commun 317: 902-908, 2004


  6. Akagi T, Inoue T, Miyoshi G, Bessho Y, Takahashi M, Lee JE, Guillemot F, Kageyama R: Requirement of multiple bHLH genes for retinal neuronal subtype specification. J Biol Chem 279: 28492-28498, 2004


  7. Hirata H, Bessho Y, Masamiz Y, Yamada S, Lewis J, Kageyama R: Instability of Hes7 protein is critical for the somite segmentation clock. Nat Genet 36: 750-754, 2004


  8. Ooto S, Akagi T, Kageyama R, Akita J, Mandai M, Honda Y, Takahashi M: Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc Natl Acad Sci USA 101: 13654-13659, 2004


  9. Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R: Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation. Development 131: 5539-5550, 2004


  10. Akagi T, Mandai M, Ooto S, Hirami Y, Osakada F, Kageyama R, Yoshimura N, Takahashi M: Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue. Invest Ophthal Vis Sci 45: 4570-4575, 2004


  11. Kodama Y, Hijikata M, Kageyama R, Shimotohno K, Chiba T: The role of Notch signaling in the development of intrahepatic bile ducts. Gastroenterology 127: 1775-1786, 2004


  12. Suzuki K, Fukui H, Kayahara T, Sawada M, Seno H, Hiai H, Kageyama R, Okano H, Chiba T: Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine. Biochem Biophys Res Commun 328: 348-352, 2005


  13. Murata K, Hattori M, Hirai N, Shinozuka Y, Hirata H, Kageyama R, Sakai T, Minato N: Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1. Mol Cell Biol 25: 4262-4271, 2005


  14. Vernay B, Koch M, Vaccarino F, Simeone A, Kageyama R, Ang S-L: Otx2 regulates subtype specification and neurogenesis in the midbrain. J Neurosci 25: 4856-4867, 2005


  15. Kageyama R, Ohtsuka T, Hatakeyama J, Ohsawa R: Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res 306: 343-348, 2005


  16. Ohsawa R, Ohtsuka T, Kageyama R: Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. J Neurosci 25: 5857-5865, 2005


川崎　能彦　（国立遺伝学研究所）
  1. Kawasaki T, Takagi Y, Yamatani H, Hirata T: Systematic screening and identification of antigens recognized by monoclonal antibodies raised against the developing lateral olfactory tract. J Neurobiol 62: 330-340, 2005


見学　美根子　（京都大学・大学院理学研究科）
  1. Yamasaki T, Kawaji K, Ono K, Bito H, Hirano T, Osumi N, Kengaku M: Pax6 regulates granule cell polarization during parallel fiber formation in the developing cerebellum. Development128: 3133-3144, 2001


  2. Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M: Delta/Notch-like EGF-related receptor (DNER), a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem 277: 25400-25407, 2002


斎藤　哲一郎　（京都大学・再生医科学研究所）
  1. Tamura M, Kanno Y, Chuma S, Saito T, Nakatsuji N: Pod-1/Capusulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1. Mech Dev 102: 135-144, 2001


  2. Saito T, Nakatsuji N: Efficient gene transfer into the embryonic mouse brain using in vivo electroporation. Dev Biol 240: 237-246, 2001


  3. Mikami A, Tynan SH, Hama T, Luby-Phelps K, Saito T, Crandall JE, Besharse JC, Vallee RB: Molecular structure of cytoplasmic dynein 2 and its distribution in neuronal and ciliated cells. J Cell Sci 115: 4801-4808, 2002


  4. Saba R, Nakatsuji N, Saito T: Mammalian BarH1 confers commissural neuron identity on dorsal cells in the spinal cord. J Neurosci 23: 1987-1991, 2003


  5. Chang CW, Tsai CW, Wang HF, Tsai HC, Chen HY, Tsai TF, Takahashi H, Li HY, Fann MJ, Yang CW, Hayashizaki Y, Saito T, Liu FC: Identification of a developmentally regulated striatum-enriched zinc-finger gene, Nolz-1, in the mammalian brain. Proc Natl Acad Sci USA 101: 2613-2618, 2004


  6. Miyagi S, Saito T, Mizutani K, Masuyama N, Gotoh Y, Iwama A, Nakauchi H, Masui S, Niwa H, Nishimoto M, Muramatsu M, Okuda A: The Sox-2 regulatory regions display their activities in two distinct multipotent stem cells. Mol Cell Biol 24: 4207-4220, 2004


  7. Mizutani K, Saito T: Progenitors resume generating neurons after temporary inhibition of neurogenesis by Notch activation in the mammalian cerebral cortex. Development 132: 1295-1304, 2005


  8. Saba R, Johnson EJ, Saito T: Commissural neuron identity is specified by a homeodomain protein, Mbh1, that is directly downstream of Math1. Development 132: 2147-2155, 2005


作田　拓　（自然科学研究機構・基礎生物学研究所）
  1. Takahashi H, Shintani T, Sakuta H, Noda M: CBF-1 controls the retinotectal topographical map along the anteroposterior axis through multiple mechanisms. Development 130: 5203-5215, 2003


  2. Shintani T, Kato A, Yuasa-Kawada J, Sakuta H, Takahashi M, Suzuki R, Ohkawara T, Takahashi H, Noda M: Large-scale identification and characterization of genes with asymmetric expression patterns in the developing chick retina. J Neurobiol 59: 34-47, 2004


笹岡　俊邦　（自然科学研究機構・基礎生物学研究所）
  1. Mizuno Y, Guyon JR, Watkins SC, Mizushima K, Sasaoka T, Imamura M, Kunkel LM, Okamoto K: Beta-synemin localizes to regions of high stress in human skeletal myofibers. Muscle Nerve 30: 337-346, 2004


佐藤　真　（福井医科大学（現・福井大学）・医学部）
  1. Tanaka M, Miyoshi J, Ishizaki H, Togawa A, Endo K, Matsubara K, Mizoguchi A, Nagano T, Sato M, Sasaki T, Takai Y: Role of Rab3 GDP/GTP exchange protein in synaptic vesicle trafficking at the mouse neuromuscular junction. Mol Biol Cell 12: 1421-1430, 2001


  2. Takamura Y, Yagi H, Hase K, Yoneda T, Maeda M, Akagi Y, Sato M: JDD1, a novel member of Dna J family, expressed in the germinal zone of the rat brain. Biochem Biophys Res Commun 285: 387-392, 2001


  3. Suzuki F, Taniguchi T, Nakamura S, Akagi Y, Kubota C, Sato M, Muramatsu M: Distribution of alpha-1 adrenoceptor subtypes in RNA and protein in rabbit eyes. Br J Pharmacol 135: 600-608, 2002


  4. Takamura Y, Kubo E, Tsuzuki S, Yagi H, Sato M, Akagi Y: Increased expression of p21WAF1/CIP1 in the lens epithelium of rat sugar cataract. Exp Eye Res 74: 245-254, 2002


  5. Nagano T, Yoneda T, Hatanaka Y, Kubota C, Murakami F, Sato M: Filamin A-interacting protein (FILIP) regulates cortical cell migration out of the ventricular zone. Nat Cell Biol 4: 495-501, 2002


  6. Kubota C, Nagano T, Baba H, Sato M: Netrin-1 is crucial for the establishment of the dorsal column-medial lemniscal system. J Neurochem 89: 1547-1554, 2004


  7. Enomoto R, Kinebuchi T, Sato M, Yagi H, Shibata T, Kurumizaka H, Yokoyama S: Positive role of the mammalian TBPIP/HOP2 protein in DMC1-mediated homologous pairing. J Biol Chem 279: 35263-35272, 2004


  8. Nagano T, Morikubo S, Sato M: Filamin A and FILIP (Filamin A-Interacting Protein) regulate cell polarity and motility in neocortical subventricular and intermediate zones during radial migration.J Neurosci 24: 9648-9657, 2004


  9. Yagi H, Takamura Y, Yoneda T, Konno D, Akagi Y, Yoshida K, Sato M: Vlgr1 knockout-mice show audiogenic seizure susceptibility. J Neurochem 92: 191-202, 2005


  10. Ando K, Nagano T, Nakamura A, Konno D, Yagi H, Sato M: Expression and characterization of disulfide bond use of oligomerized A2-Pancortins: extracellular matrix constituents in the developing brain.Neuroscience 133: 947-957, 2005


新谷　隆史　（岡崎共同研究機構（現・自然科学研究機構）・基礎生物学研究所）
  1. Suzuki R, Shintani T, Sakuta H, Kato A, Ohkawara T, Osumi N, Noda M: Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed in the ventral region of the retina. Mech Dev 98: 37-50, 2000


  2. Shintani T, Maeda N, Noda M: Receptor-like protein tyrosine phosphatase gamma (RPTPgamma), but not PTPzeta/RPTPbeta, inhibits nerve-growth-factor-induced neurite outgrowth in PC12D cells. Dev Neurosci 23: 55-69, 2001


  3. Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura SH, Yamamoto TS, Ueno N, Noda M: Ventroptin: A BMP-4 antagonist expressed in a double-gradient pattern in the retina. Science 293: 111-115, 2001


須田　容子　（理化学研究所・発生再生科学研究センター）
  1. Suda Y, Hossain ZM, Kobayashi C, Hatano O, Yoshida M, Matsuo I, Aizawa S: Emx2 directs the development of diencephalon in cooperation with Otx2. Development 128: 2433-2450, 2001


  2. Shinozaki K, Miyagi T, Yoshida M, Miyata T, Ogawa M, Aizawa S, Suda Y: Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double mutant cerebral cortex. Development 129: 3479-3492, 2002


高田　真治　（京都大学・大学院理学研究科）
  1. Takeda K, Yasumoto K, Takada R, Takada S, Watanabe K, Udono T, Saito H, Takahashi K, Shibahara S: Induction of melanocyte-specific microphthalmia-associated transcription factor by Wnt-3a. J Biol Chem 275: 14013-14016, 2000


  2. Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami Y: Mouse Ror2 receptor tyrosine kinase is required for the heart development and limb formation. Genes Cells 5: 71-78, 2000


  3. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino Si, Michiue T, Takada S, Asashima M, Kikuchi A: A novel beta-catenin-binding protein inhibits beta-catenin-dependent tcf activation and axis formation. J Biol Chem 275: 32871-32878, 2000


  4. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of β-catenin and Down-regulates β-Catenin. J Biol Chem 275: 34399-34406, 2000


  5. Takahashi N, Ishihara S, Takada S, Tsukita S, Nagafuchi A: Posttranscriptional regulation of α-catenin expression is required for Wnt signaling in L cells. Biochem Biophys Res Commun 277: 691-698, 2000


  6. Ikeya M, Takada S: Wnt-3a is required for somite specification along anteroposterior axis of the mouse embryo and regulates cdx-1 expression. Mech Dev 103: 27-33, 2001


  7. Hino S-I, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A: Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol 21: 330-342, 2001


  8. Ueda Y, Hijikata M, Takagi S, Takada R, Takada S, Chiba T, Shimotohno K: p73beta, a variant of p73, enhances Wnt/beta-catenin signaling in Saos-2 cells. Biochem Biophys Res Commun 283: 327-333, 2001


  9. Jin EJ, Erickson CA, Takada S, Burrus LW: Wnt and bmp signaling govern lineage segregation of melanocytes in the avian embryo. Dev Biol 233: 22-37, 2001


  10. Mao J, Wang J, Liu B, Pan W, Farr GH, Flynn C, Yuan H, Takada S, Kimelman D, Li L, Wu D: Low-density lipoprotein receptor-related protein-5 binds to axin and regulates the canonical wnt signaling pathway. Mol Cell 7: 801-809, 2001


  11. Kawamura Y, KikuchiA, TakadaR, TakadaS, SudohS, ShibamotoS, YanagisawaK, KomanoH: Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of beta-catenin phosphorylation. Eur J Biochem 268: 3036-3041, 2001


  12. Yamane T, Kunisada T, Tsukamoto H, Yamazaki H, Niwa H, Takada S, Hayashi S-I: Wnt signaling regulates hematopoiesis through stromal cells. J Immunol 167: 765-772, 2001


  13. Kojima T, Yoshikawa Y, Takada S, Sato M, Nakamura T, Takahashi N, Copeland NG, Gilbert DJ, Jenkins NA, Mori N: Genomic organization of the Shc-related phosphotyrosine adapters and characterization of the full-length Sck/ShcB: Specific association of p68-Sck/ShcB with pp135. Biochem Biophys Res Commun 284: 1039-1047, 2001


  14. Matsuda T, Nomi M, Ikeya M, Kani S, Oishi I, Terashima T, Takada S, Minami Y: Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development. Mech Dev 105: 153-156, 2001


  15. Kawauchi T, Ikeya M, Takada S, Ueda K, Shirai M, Takihara Y, Kioka N, Amachi T: Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal. Mech Dev 106: 147-150, 2001


  16. Yao R, Maeda T, Takada S, Noda T: Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled. Biochem Biophys Res Commun 286: 771-778, 2001


  17. Nomi M, Oishi I, Kani S, Suzuki H, Matsuda T, Yoda A, Kitamura M, Itoh K, Takeuchi S, Takeda K, Akira S, Ikeya M, Takada S, Minami Y: Loss of mRor1 enhances the heart and skeletal abnormalities in mRor2-deficient mice: Redundant and pleiotropic functions of mRor1 and mRor2 receptor tyrosine kinases. Mol Cell Biol 21: 8329-8335, 2001


高橋　政代　（京都大学・大学院医学研究科）
  1. Nishida A, Takahashi M, Tanihara H, Nakano I, Takahashi BJ, Mizoguchi A, Ide C, Honda Y: Incorporation and differentiation of hippocampus-derived neural stem cells transplanted in injured adult rat retina. Invest Ophthalmol Vis Sci 41: 4268-4274, 2000.


  2. Mandai M, Takahashi M, Miyamoto H, Hiroshiba N, Kimura H, Ogura Y, Honda Y, Sasai K: Long-term outcome after radiation therapy for subfoveal choroidal neovascularization associated with age-related macular degeneration. Jpn J Ophthalmol 44: 530-537, 2000


  3. Kurimoto Y, Shibuki H, Kaneko Y, Ichikawa M, Kurokawa T, Takahashi M, Yoshimura N: Transplantation of adult rat hippocampus-derived neural stem cells into retina injured by transient ischemia. Neurosci Lett 306: 57-60, 2001


  4. Inatani M, Haruta M, Honjo M, Oohira A, Kido N, Takahashi M, Honda Y, Tanihara H: Upregulated expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in differentiated neural stem cells. Brain Res 920: 217-221, 2001


  5. Haruta M, Kosaka M, Kanegae Y, Saito I, Inoue T, Kageyama R, Nishida A, Honda Y, Takahashi M: Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue. Nat Neurosci 4: 1163-1164, 2001


  6. Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, Haruta M, Takahashi M, Yoshikawa K, Nishikawa SI, Nakatsuji N, Sasai Y: Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity. Proc Natl Acad Sci USA 99: 1580-5200, 2002


  7. Akita J, Takahashi M, Hojo M, Nishida A, Haruta M, Honda Y: Neuronal differentiation of adult rat hippocampus-derived neural stem cell transplanted into embryonic rat explanted retinas with retinoic acid pretreatment. Brain Res 954: 286-293, 2002


竹林　浩秀　（岡崎国立共同研究機構・生理学研究所）
  1. Ding H, Shannon P, Lau N, Wu X, Roncari L, Baldwin RL, Takebayashi H, Nagy A, Gutmann DH, Guha A: Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model. Cancer Res 63: 1106-1113, 2003


  2. Ivanova A, Nakahira E, Kagawa T, Oba A, Wada T, Takebayashi H, Spassky N, Levine J, Zalc B, Ikenaka K: Evidence for a second wave of oligodendrogenesis in the postnatal cerebral cortex of the mouse. J Neurosci Res 73: 581-592, 2003


  3. Iwasaki Y, Hosoya T, Takebayashi H, Ogawa Y, Hotta Y, Ikenaka K: The potential to induce glial differentiation is conserved between Drosophila and mammalian glial cells missing (gcm) genes. Development 130: 6027-6035, 2003


  4. Fukuda S, Kondo T, Takebayashi H, Taga T: Negative regulatory effect of an oligodendrocytic bHLH factor OLIG2 on the astrocyte differentiation pathway. Cell Death Differ 11: 196-202, 2004


  5. Yokoo H, Nobusawa S, Takebayashi H, Ikenaka K, Isoda K, Kamiya M, Sasaki A, Hirato J, Nakazato Y: Anti-human Olig2 antibody as a useful immunohistochemical marker of normal oligodendrocytes and gliomas. Am J Pathol 164: 1717-1725, 2004


  6. Agius E, Soukkarich C, Danesin C, Kan P, Takebayashi H, Soula C, Cochard P: Converse control of oligodendrocyte and astrocyte lineage development by Sonic hedgehog in the chick spinal cord. Dev Biol 270: 308-321, 2004


  7. Masahira N, Ding L, Takebayashi H, Shimizu K, Ikenaka K, Ono K: Improved preservation of X-gal reaction product for electron microscopy using hydroxypropyl methacrylate. Neurosci Lett 374: 17-20, 2005


田中　光一　（東京医科歯科大学・難治疾患研究所）
  1. Hakuba N, Koga K, Gyo K, Usami S, Tanaka K: Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci 20: 8750-8753, 2000


  2. Yamada K, Fukaya M, Shibata T, Kurihara H, Tanaka K, Inoue Y, Watanabe M: Dynamic transformation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth of cerebellar Purkinje cells. J Comp Neurol 418: 106-120, 2000


  3. Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, Attwell D: Glutamate does not play a major role in controlling bone growth. J Bone Miner Res 16: 742-749, 2001


  4. Sugiyama T, Sadzuka Y, Tanaka K, Sonobe T: Inhibition of glutamate transporter by theanine enhances the therapeutic efficacy of doxorubicin. Toxicol Lett 121: 89-96, 2001


  5. Katagiru H, Tanaka K, Manabe T: Requirement of appropriate glutamate concentrations in the synaptic cleft for hippocampal LTP induction. Eur J Neurosci 14: 547-553, 2001


  6. Harada T, Harada C, Kohsaka S, Wada E, Yoshida K, Ohno S, Mamada H, Tanaka K, Parada LF, Wada K: Microglia-Muller glia interactions control neurotrophic factor productions during light-induced retinal degeneration. J Neurosci22: 9228-9236, 2002


  7. Nishizaki T, Nagai K, Nomura T, Tada H, Kanno T, Tozaki T, Li X, Kondoh T, Kodama N, Takahashi E, Sakai N, Tanaka K, Saito N: A new neuromodulator pathway with a glial contribution mediated via A2a adrenergic receptors. Glia 39: 133-147, 2002


  8. Jin ZH, Kikuchi T, Tanaka K, Kobayashi T: Expression of GLAST in the developing mouse cochlea. Tohoku J Exp Med 200: 137-144, 2003


  9. Harada C, Harada T, Quah H-MA, Maekawa F, Yoshida K, Ohno S, Wada K, Parada LF, Tanaka K: Potential role of glial cell line-derived neurotrophic factor receptors in Muller glial cells during light-induced retinal degeneration. Neuroscience 122: 229-235, 2003


  10. Mitani A, Tanaka K: Functional changes of glial glutamate transporter GLT-1 during ischemia: An in vivo study in the hippocampal CA1 of normal mice and of mutant mice lacking GLT-1. J Neurosci 23: 7176-7182, 2003


  11. Voutsinos-Porche B, Knott G, Tanaka K, Quairiaux C, Welker E, Bonvento G: Glial glutamate transporters and maturation of the mouse somatosensory cortex. Cereb Cortex 13: 1110-1121, 2003


  12. Iwabuchi M, Ui-Tei K, Yamada Y, Matsuda Y, Sakai Y, Tanaka K, Ohki-Hamazaki H: Molecular cloning and characterization of avian bombesin-like peptide receptors: New tools for investigating molecular basis for ligand selectivity. Br J Pharmacol 139: 555-566, 2003


  13. Mitamura Y, Harada T, Harada C, Ohtsuka K, Kotake S, Ohno S, Tanaka K, Takeuchi S, Wada K: NF-kB in epiretinal membranes after human diabetic retinopathy. Diabetologia 46: 699-703, 2003


  14. Okada T, Yamada N, Tsuzuki K, Horikawa PM, Tanaka K, Ozawa S: Long-term potentiation in the hippocampal CA1 area and dentategyrus plays different roles in spatial learning. Eur J Neurosci 17: 341-349, 2003


  15. Voutsinos-Porche B, Bonvento G, Tanaka K, Welker E, Chatton J-Y, Magistretti PJ, Pellerin L: Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex. Neuron 37: 275-286, 2003


  16. Sarthy VP, Pignataro L, Marc R, Tanaka K: The contribution of a glial glutamate transporter to GABA synthesis in the retina. NeuroReport 15: 1895-1898, 2004


  17. Sarthy VP, Dudley VJ, Tanaka K: Retinal glucose metabolism in mice lacking the L-glutamate/aspartate transporter. Vis Neurosci 21: 637-643, 2004


  18. Huang YH, Tanaka K, Rothstein JD, Bergles DE: Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24: 4498-4509, 2004


  19. Maekawa F, Tsukahara S, Tanaka K, Ohki-Hamazaki H: Distributions of two chicken bombesin receptors, bombesin receptor subtype-3.5 (chBRS-3.5) and gastrin-releasing peptide receptor (chGRP-R) mRNA's in chicken telencephalon. Neuroscience 125: 569-582, 2004


  20. Maekawa F, Quah H-MA, Tanaka K, Ohki-Hamazaki H: Leptin resistance and enhancement of feeding facilitation by melanin-concentrating hormone in mice lacking bombesin receptor subtype-3. Diabetes 53: 570-576, 2004


  21. Chen W, Mahadomrongkul V, Berger UV, Bassan M, DeSilva T, Tanaka K, Irwin N, Aoki C,Rosenberg PA: The glutamate transporter GLT1a is expressed in excitatory axon terminals of mature hippocampal neurons. J Neurosci 24: 1136-1148, 2004


  22. Harada C, Harada T, Mitamura Y, Quah H-MA, Ohtsuka K, Kotake S, Ohno S, Wada K, Takeuchi S, Tanaka K: Diverse NF-kB expression in epiretinal membranes after human diabetic retinopathy and proliferative vitreoretinopaty. Mol Vision 10: 31-36, 2004


  23. Huang Y, Dykes Hoberg M, Tanaka K, Rothstein JD, Bergles DE: Climbing fiber activation of EAAT4 transporters and kainite receptors in cerebellar Purkinje cells. J Neurosci 24: 103-111, 2004


  24. Harada T, Harada C, Wang Y-U, Osaka H, Amanai K, Tanaka K, Takizawa S, Setsuie R, Sakurai M, Sato Y, Noda M, Wada K: Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. Am J Pathol 164: 59-64, 2004


  25. Harada C, Harada T, Quah H-MA, Namekata K, Yoshida K, Ohno S, Tanaka K, Parada LF: Role of Neurotrophin-4/5 in neural cell death during retinal development and ischemic retinal injury in vivo. Invest Ophthalmol Vis Sci 46: 669-673, 2005


  26. Sarthy VP, Pignataro L, Pannicke T, Weick M, Reichenbach A, Harada T, Tanaka K, Marc R: Glutamate transporter in retinal Muller cells from glutamate/aspartate transporter (GLAST) knockout mice. Glia 49: 184-196, 2005


谷口　雅彦　（東京大学・大学院医学系研究科）
  1. Ito T, Kagoshima M, Sasaki Y, Li C, Udaka N, Kitsukawa T, Fujisawa H, Taniguchi M, Yagi T, Kitamura H, Goshima Y: Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung. Mech Dev 97: 35-45, 2000


  2. Sugimoto Y, Taniguchi M, Yagi T, Akagi Y, Nojyo Y, Tamamaki N: Guidance of glial precursor cell migration by secreted cues in the developing optic nerve. Development 128: 3321-3330, 2001


  3. Løes S, Kettunen P, Kvinnsland HI, Taniguchi M, Fujisawa H, Luukko K: Expression of class 3 semaphorins and neuropilin receptors in the developing mouse tooth. Mech Dev 101: 185-188, 2001


  4. Sasaki Y, Cheng C, Uchida Y, Nakajima O, Ohshima T, Yagi T, Taniguchi M, Nakayama T, Kishida R, Kudo Y, Ohno S, Nakamura F, Goshima Y: Fyn and cdk5 mediate semaphorin 3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex. Neuron 35: 907-920, 2002


  5. Mukouyama Y, Shin D, Britsch S, Taniguchi M, Anderson JD: Sensory nerves determine the pattern of arterial differentiation and blood vessel branching in the skin. Cell 109: 693-705, 2002


  6. Kawasaki T, Bekku Y, Suto F, Kitsukawa T, Taniguchi M, Nagatsu I, Nagatsu T, Itoh K, Yagi T, Fujisawa H: Requirement of neuropilin 1-mediated Sema3A signals in patterning of the sympathetic nervous system. Development 129: 671-680, 2002


谷藤（森本）高子　（東京大学・大学院理学系研究科）
  1. Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-Morimoto T, Yuasa Y, Yoshihara Y, Nose A, Okano H: Gal4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways. J Neurosci Res 59: 94-99, 2000


  2. Kazama H, Morimoto-Tanifuji T, Nose A: Postsynaptic activation of CaMKII promotes coordinated pre- and postsynaptic maturation of Drosophila neuromuscular junctions. Neuroscience 117: 615-625, 2003


  3. Morimoto-Tanifuji T, Kazama H, Nose A: Developmental stage-dependent modulation of synapses by postsynaptic expression of activated calcium/calmodulin-dependent kinase II. Neuroscience 128: 797-806, 2004


玉巻　伸章　（熊本大学・大学院医学薬学研究部）
  1. Tamamaki N, Fujimori K, Nojyo Y, Kaneko T, Takauji R: Evidence that sema3A and 3F regulate the migration of GABAergic neurons in the developing neocortex. J Comp Neurol 455: 238-248, 2002


  2. Fujimori K, Takauji R, Tamamaki N: Differential localization of high- and low-molecular-weight variants of MAP2 in the developing rat telencephalon. J Comp Neurol 449: 330-342, 2002


  3. Tamamaki N, Yanagawa Y, Tomioka Y, Miyazaki J, Obata K, Kaneko T: Green fluorescent protein expression and colocalization with calretinin, parvalbumin, and somatostatin in the GAD67-GFP knock-in mouse. J Comp Neurol 467: 60-79, 2003


  4. Hioki H, Fujiyama F, Taki K, Tomioka R, Furuta T, Tamamaki N, Kaneko T: Differential distribution of vesicular glutamate transporters in the rat cerebellar cortex. Neuroscience 117: 1-6, 2003


  5. Fujiyama F, Hioki H, Tomioka R, Taki K, Tamamaki N, Nomura S, Okamoto K, Kaneko T: Changes of immunocytochemical localization of vesicular glutamate transporters in the rat visual system after the retinofugal denervation. J Comp Neurol 465: 234-249, 2003


  6. Tomioka R, Okamoto K, Furuta T, Fujiyama F, Iwasato T, Yanagawa Y, Obata K, Kaneko T, Tamamaki N: Demonstration of long-range GABAergic connections distributed throughout the mouse neocortex. Eur J Neurosci 21: 1587-1600, 2005


  7. Xu Y, Tamamaki N, Noda T, Kimura K, Itokazu Y, Matsumoto N, Dezawa M, Ide C: Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol 192: 251-264, 2005


田村　宏治　（東北大学・生命科学研究科）
  1. Tamura K, Amano T, Satoh T, Saito D, Yonei-Tamura S, Yajima H: Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. Mech Dev 120: 199-209, 2003


  2. Yajima H, Hara K, Ide H, Tamura K: Cell adhesiveness and affinity for limb pattern formation. Int J Dev Biol 46: 897-904, 2002


  3. Saito D, Yonei-Tamura S, Kano K, Ide H, Tamura K: Specification and determination of limb identity: evidence for inhibitory regulation on Tbx gene expression. Development 129: 211-220, 2002


坪井　昭夫　（東京大学・大学院理学系研究科）
  1. Serizawa S, Ishii T, Nakatani H, Tsuboi A, Nagawa F, Asano M, Sudo K, Sakagami J, Sakano H, Ijiri T, Matsuda Y, Suzuki M, Yamamori T, Iwakura Y, Sakano H: Mutually exclusive expression of odorant receptor transgenes. Nat Neurosci 3: 687-693, 2000


  2. Ishii T, Serizawa S, Kohda A, Nakatani H, Shiroishi T, Okumura K, Iwakura Y, Nagawa F, Tsuboi A, Sakano H: Monoallelic expression of the odourant receptor gene and axonal projection of olfactory sensory neurones. Genes Cells 6: 71-78, 2001


  3. Sengoku S, Ishii T, Serizawa S, Nakatani H, Nagawa F, Tsuboi A, Sakano H: Axonal projection of olfactory sensory neurons during the developmental and regeneration processes. NeuroReport 12: 1061-1066, 2001


  4. Nagawa F, Yoshihara S, Tsuboi A, Serizawa S, Itoh K, Sakano H: Genomic analysis of the murine odorant receptor MOR28 cluster: a possible role of gene conversion in maintaining the olfactory map. Gene292: 73-80, 2002


  5. Kobayakawa K, Hayashi R, Morita K, Miyamichi K, Oka Y, Tsuboi A, Sakano H: Stomatin-related olfactory protein, SRO, specifically expressed in the murine olfactory sensory neurons. J Neurosci 22: 5931-5937, 2002


  6. Nishizumi H, Komiyama T, Miyabayashi T, Sakano S, Sakano H: BET, a novel neuronal transmembrane protein with multiple EGF-like motifs. NeuroReport 13: 909-915, 2002


  7. Oka Y, Kobayakawa K, Nishizumi H, Miyamichi K, Hirose S, Tsuboi A, Sakano H: O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner. Eur J Biochem 270: 1995-2004, 2003


  8. Umemori H, Ogura H, Tozawa N, Mikoshiba K, Nishizumi H, Yamamoto T: Impairment of N-methyl-D-aspartate receptor-controlled motor activity in lyn-deficient mice. Neuroscience 118: 709-713, 2003


  9. Nagawa F, Hirose S, Nishizumi H, Nishihara T, Sakano H: Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA. J Biol Chem 279: 38360-38368, 2004


  10. Nishihara T, Nagawa F, Nishizumi H, Kodama M, Hirose S, Hayashi R, Sakano H: In vitro processing of the 3’-overhanging DNA in the postcleavage complex involved in V(D)J joining. Mol Cell Biol 24: 3692-3702, 2004


豊岡　和人　（大阪市立大学・大学院医学研究科）
  1. Toyo-oka K, Hirotsune S, Gambello MJ, Zhou Z-Q, Olson L, Rosenfeld MG, Eisenman R, Hurlin P, Wynshaw-Boris A: Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome. Hum Mol Genet 13: 1057-1067, 2004


  2. Hurlin PJ, Zhou ZQ, Toyo-oka K, Ota S, Walker WL, Hirotsune S, Wynshaw-Boris A: Evidence of mnt-myc antagonism revealed by mnt gene deletion. Cell Cycle 3: 97-99, 2004


  3. Sasaki S, Mori D, Toyo-oka K, Chen A, Garrett-Beal L, Muramatsu M, Miyagawa S, Hiraiwa N, Yoshiki A, Wynshaw-Boris A, Hirotsune S: Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality. Mol Cell Biol 25: 7812-7827, 2005


仲嶋　一範　（慶應義塾大学・医学部）
  1. Yip WJ, Yip LPY, Nakajima K, Capriotti C: Reelin controls position of autonomic neurons in the spinal cord. Proc Natl Acad Sci USA 97: 8612-8616, 2000


  2. Utsunomiya-Tate N, Kubo K, Tate S, Kainosho M, Katayama E, Nakajima K, Mikoshiba K: Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody. Proc Natl Acad Sci USA97: 9729-9734, 2000


  3. Tabata H, Nakajima K: Efficient in utero gene transfer system to the developing mouse brains using electroporation: Visualization of neuronal migration in the developing cortex. Neuroscience 103: 865-872, 2001


  4. Kubo K, Mikoshiba K, Nakajima K: Secreted Reelin molecules form homodimers. Neurosci Res 43: 381-388, 2002


  5. Tabata H, Nakajima K: Neurons tend to stop migration and differentiate along the cortical internal plexiform zones in the Reelin signal-deficient mice. J Neurosci Res 69: 723-730, 2002


  6. Soda T, Nakashima R, Watanabe D, Nakajima K, Pastan I, Nakanishi S: Segregation and coactivation of developing neocortical layer 1 neurons. JNeurosci 23: 6272-6279, 2003


  7. Tabata H, Nakajima K: Multipolar migration: the third mode of radial neuronal migration in the developing cerebral cortex. J Neurosci 23: 9996-10001, 2003


  8. Yip PY, Capriotti C, Magdaleno S, Benhayon D, Curran T, Nakajima K, Yip WJ: Components of the Reelin signaling pathway are expressed in the spinal cord. J Comp Neurol 470: 210-219, 2004


  9. Hirabayashi Y, Itoh Y, Tabata H, Nakajima K, Akiyama T, Masuyama N, Gotoh Y: The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells. Development 131: 2791-2801, 2004


  10. Yozu M, Tabata H, Nakajima K: Birth-date dependent alignment of GABAergic neurons occurs in a different pattern from that of non-GABAergic neurons in the developing mouse visual cortex. Neurosci Res 49: 395-403, 2004


  11. Kudo C, Ajioka I, Hirata Y, Nakajima K: Expression profiles of EphA3 at both the RNA and protein level in the developing mammalian forebrain. J Comp Neurol 487: 255-269, 2005


  12. Ajioka I, Nakajima K: Birth-date-dependent-segregation of the mouse cerebral cortical neurons in reaggregation cultures. Eur J Neurosci 22: 331-342, 2005


  13. Yozu M, Tabata H, Nakajima K: The caudal migratory stream: a novel migratory stream of interneurons derived from the caudal ganglionic eminence in the developing mouse forebrain. J Neurosci 25: 7268-7277, 2005


中島　欽一　（熊本大学・発生医学研究センター）
  1. Chijiwa T, Deshimaru M, Nobuhisa I, Nakai M, Ogawa T, Oda N, Nakashima K, Fukumaki Y, Shimohigashi Y, Hattori S, Ohno M: Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan. Biochem J 347: 491-499, 2000


  2. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification of a novel WD repeat-containing gene predominantly expressed in developing and regenerating neurons. J Biochem 128: 923-932, 2000


  3. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem 275: 17647-17652, 2000


  4. Kojima N, Kinoshita T, Kamiya A, Nakamura K, Nakashima K, Taga T, Miyajima A: Cell density-dependent regulation of hepatic development by a gp130-independent pathway. Biochem Biophys Res Commun 277: 152-158, 2000


  5. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T: Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Gene 254: 29-35, 2000


  6. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono K, Sicinska W, VanHooke J, DeLuca HF, Yamada S: Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain. Proc Natl Acad Sci USA 97: 1467-1472, 2000


  7. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto T, Hisatsune T, Taga T: Astrocyte differentiation of fetal neuroepithelial cells by interleukin-11 via activation of a common cytokine signal transducer, gp130, and a transcription factor, STAT3. J Neurochem 74: 1498-1504, 2000


  8. Choi M, Yamamoto K, Masuno H, Nakashima K, Taga T, Yamada S: Ligand recognition by the vitamin D receptor. Bioorg Med Chem 9: 1721-1730, 2001


  9. Kohyama J, Abe H., Shimazaki T, Koizumi A, Nakashima K, Gojo S, Taga T, Okano H, Hata J, Umezawa A: Brain from bone: efficient “meta-differentiation” of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent. Differentiation 68: 235-244, 2001


  10. Matsuo R, Ochiai W, Nakashima K, Taga T: A new expression cloning strategy for isolation of substrate-specific kinases by using phosphorylation site-specific antibody. J Immunol Methods 247: 141-151, 2001


  11. Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration in the developmental pathway of fetal mouse brain cells from neurogenesis to astrocytogenesis. Proc Natl Acad Sci USA 98: 5868-5873, 2001


  12. Ochiai W, Yanagisawa M, Takizawa T, Nakashima K, Taga T: Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of stat3. Cytokine 14: 264-271, 2001


  13. Setoguchi T, Yone K, Matsuoka E, Takenouchi H, Nakashima K, Sakou T, Komiya S, Izumo S: Traumatic injury-induced BMP7 expression in the adult rat spinal cord. Brain Res 921: 219-225, 2001


  14. Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima K, Taga T: Directly linked soluble il-6 receptor-il-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of stat3. Cytokine 13: 272-279, 2001


  15. Takizawa T, Nakashima K, Namihira M, Ochiai W, Uemura A, Yanagisawa M, Fujita N, Nakao M, Taga T: DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. Dev Cell 1: 749-758, 2001


  16. Ueno M, Igarashi K, Kimura N, Okita K, Takizawa M, Nobuhisa I, Kojima T, Kitamura T, Samulowitz U, Vestweber D, Shimomura T, Suda T, Nakashima K, Taga T: Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion. Biochem Biophys Res Commun 287: 501-506, 2001


  17. Yanagisawa M, Nakashima K, Takizawa T, Ochiai W, Arakawa H, Taga T: Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines. FEBS Lett 489: 139-143, 2001


  18. Yanagisawa M, Takizawa T, Ochiai W, Uemura A, Nakashima K, Taga T: Fate alteration of neuroepithelial cells from neurogenesis to astrocytogenesis by bone morphogenetic proteins. Neurosci Res 41: 391-396, 2001


  19. Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T: Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. Genes Cells 6: 1091-1099, 2001


  20. Hatta T, Moriyama K, Nakashima K, Taga T, Otani H: The role of gp130 in cerebral cortical development: In vivo functional analysis in a mouse exo utero system. J Neurosci 22: 5516-5524, 2002


  21. Kimura N, Takizawa M, Okita K, Natori O, Igarashi K, Ueno M, Nakashima K, Nobuhisa I, Taga T: Identification of a novel transcription factor, ELYS, expressed predominantly in mouse foetal haematopoietic tissues. Genes Cells 7: 435-446, 2002


  22. Uemura A, Takizawa T, Ochiai W, Yanagisawa M, Nakashima K, Taga T: Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of stat3. Cytokine 18: 1-7, 2002


  23. Nakashima K, Taga T: Mechanisms underlying cytokine-mediated cell-fate regulation in the nervous system. Mol Neurobiol 25: 233-244, 2002


中村　勉　（東京大学・分子細胞生物学研究所）
  1. Sekiya T, Nakamura T, Kazuki Y, Oshimura M, Kohu K, Tago K, Ohwada S, Akiyama T: Overexpression of Icat induces G2 arrest and cell death in tumor cell mutants for adenomatous polyposis coli, β-catenin, or Axin. Cancer Res 62: 3322-3326, 2002


  2. Koyama T, Tago K, Nakamura T, Ohwada S, Morishita Y, Yokota J, Akiyama T: Mutation and expression of the β-catenin-interacting protein ICAT in human colorectal tumors. Jpn J Clin Oncol 32: 358-362, 2002


  3. Okabe T, Nakamura T, Nishimura Nasu Y, Kohu K, Ohwada S, Morishita Y, Akiyama T: RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the β-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling. J Biol Chem 278: 9920-9927, 2003


  4. Sekiya T, Adachi S, Kohu K, Yamada T, Higuchi O, Furukawa Y, Nakamura Y, Nakamura T, Tashiro K, Kuhara S, Ohwada S, Akiyama T: Identification of BMP and activin membrane-bound inhibitor (BAMBI ), an inhibitor of transforming growth factor-β signaling, as a target of the β-catenin pathway in colorectal tumor cells. J Biol Chem 279: 6840-6846, 2004


  5. Satoh K, Kasai M, Ishidao T, Tago K, Ohwada S, Hasegawa Y, Senda T, Takada S, Nada S, Nakamura T, Akiyama T: Anteriorization of neural fate by inhibitor of β-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling. Proc Natl Acad Sci USA 101: 8017-8021, 2004


  6. Imai M, Nakamura T, Akiyama T, Horii A: Infrequent somatic mutations of the ICAT gene in various human cancers with frequent 1p-LOH and/or abnormal nuclear accumulation of β-catenin. Oncol Rep 12: 1099-1103, 2004


  7. Adachi S, Jigami T, Yasui T, Nakano T, Ohwada S, Omori Y, Sugano S, Ohkawara B, Shibuya H, Nakamura T, Akiyama T: Role of a BCL9-related β-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res 64: 8496-8501, 2004


仲村　春和　（東北大学・加齢医学研究所）
  1. Nakamura, H., Sugiyama, S: Polarity and laminar formation of the optic tectum in relation to retinal projection. J Neurobiol 59: 48-56, 2004


  2. Sato T, Joyner AL, Nakamura H: How does Fgf signaling from the isthmic organizer induce midbrain and cerebellum development? Dev Growth Differ 46: 487-94, 2004


  3. Nakamura H, Katahira T, Watanabe Y, Funahashi J: Gain- and loss-of-function in chick embryos by electroporation. Mech Dev121: 1137-1143, 2004


  4. Nakamura H, Watanabe Y: Isthmus organizer and regionalization of the mesencephalon and metencephalon. Int J Dev Biol 49: 231-235, 2005


  5. Watanabe Y, Toyoda R, Nakamura H: Navigation of trochlear axons along the midbrain-hindbrain boundary to neuropilin-2. Development 131: 681-692, 2004


  6. Kimura J, Katahira T, Araki I, Nakamura H: Possible role of Hes5 for the rostrocaudal polarity formation of the tectum. Dev Growth Differ 46: 219-227, 2004


  7. Sato T, Nakamura H: The Fgf8 signal causes cerebellar differentiation by activating Ras-ERK signaling pathway. Development 131: 4275-4285, 2004


  8. Suzuki-Hirano A, Sato T, Nakamura H: Regulation of isthmic Fgf8 signal by sprouty2. Development 132: 257-265, 2005


  9. Ozaki H, Nakamura K, Funahashi J, Ikeda K, Yamada G, Tokano H, Okamura HO, Kitamura K, Muto S, Kotaki H, Sudo K, Horai R, Iwakura Y, Kawakami K: Six1 controls patterning of the mouse otic vesicle. Development 131: 551-562, 2004


  10. Lee SK, Jurata LW, Funahashi J, Ruiz EC, Pfaff SL: Analysis of embryonic motoneuron gene regulation: derepression of general activators function in concert with enhancer factors. Development 131: 3295-3306, 2004


中村　史雄　（横浜市立大学・医学部）
  1. Lee J, Nakane Y, Koshikawa N, Nakayama K, Hayashi M, Takenaga K: Characterization of a zinc finger protein ZAN75: nuclear localization signal, transcriptional activator activity, and expression during neuronal differentiation of P19 Cells. DNA Cell Biol 19: 227-234, 2000


  2. Masumoto J, Taniguchi S, Nakayama K, Ayukawa K, Sagara J: Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Exp Cell Res 262: 128-133, 2001


  3. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaidou T, Nakayama K, Kiyosawa K: Pancreatitis associated with elevated levels of IgG4 in serum. N Engl J Med 344: 732-738, 2001


  4. Sugane K, Takamoto M, Nakayama K, Tada T, Yuasa T, Kurokawa K: Diagnosis of toxoplasma meningoencephalitis in a non-AIDS patient using PCR. J Infection 42: 159-160, 2001


  5. Li W, Okano A, Tiana BQ, Nakayama K, Furihata T, Nawa H, Suzuki T: Characterization of a novel synGAP isoform, synGAP-beta. J Biol Chem 276: 21417-21424, 2001


  6. Kawa S, Nikaido T, Unno H, Usuda N, Nakayama K, Kiyosawa K: Growth inhibition and differentiation of pancreatic cancer cell lines by PPARγ ligand troglitazone through the up-expression of WAF1/CIP1/p21. Pancreas 24: 1-7, 2002


  7. Ebara S, Nakayama K: The regulatory mechanism of BMP expression and its signal transduction. Spine 27: 165-171, 2002


  8. Ohta K, Nakayama K, Kurokawa T, Kikuchi T, Yoshimura N: Inhibitory effects of pyrrolidine dithiocarbamate on endotoxin-induced uveitis in lewis rats. Invest Ophthalmol Vis Sci 43: 744-750, 2002


  9. Kawa S, Ota M, Yoshizawa K, Horiuchi A, Hamano H, Ochi Y, Nakayama K, Tokutake Y, Katsuyama Y, Saito S, Hasebe O, Kiyosawa K: HLA DRB10405-DQB10401 haplotype is associated with autoimmune pancreatitis in the Japanese population. Gastroenterology 122: 1264-1269, 2002


根岸　学　（京都大学・大学院生命科学研究所）
  1. Fujita H, Katoh H, Hasegawa H, Yasui H, Aoki J, Yamaguchi Y, Negishi M: Molecular decipherment of Rho effector pathways regulating tight junction permeability. Biochem J 346: 617-622, 2000


  2. Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, Negishi M: Immunohistochemical localization of prostaglandin EP3 receptor in the rat nervous system. J Comp Neurol 421: 543-569, 2000


  3. Yamaguchi Y, Katoh H, Yasui H, Aoki J, Nakamura K, Negishi M: Gα12 and Gα13 inhibit Ca2+-dependent exocytosis through Rho/Rho-associated kinase-dependent pathway. J Neurochem 75: 708-717, 2000


  4. Hasegawa H, Katoh H, Yamaguchi Y, Nakamura K, Futakawa S, Negishi M: Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxyl-terminal tail structures. FEBS Lett 473: 76-80, 2000


  5. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K: ATF6 activated by proteolysis binds in the presence of NF-Y/CBF directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 20: 6755-6767, 2000


  6. Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M: Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells. Mol Cell Biol 20: 7378-7387, 2000


  7. Hasegawa H, Katoh H, Fujita H, Mori K, Negishi M: Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin. Biochem Biophys Res Commun 276: 350-354, 2000


  8. Aoki J, Katoh H, Mori K, Negishi M: Rnd1, a novel Rho family GTPase, induces the formation of neuritic processes in PC12 cells. Biochem Biophys Res Commun 278: 604-608, 2000


  9. Nakamura K, Li Y-Q, Kaneko T, Negishi M: Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain. Neuroscience 103: 763-775, 2001


  10. Yasui H, Katoh H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M: Differential responses to NGF and EGF in neurite outgrowth of PC12 cells are determined by Rac1 activation systems. J Biol Chem 276: 15298-15305, 2001


  11. Yoshida H, Okad T, Haze K, Yanagi H, Yura T, Negishi M, Mori K: Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6α and 6β that activates the mammalian unfolded protein response. Mol Cell Biol 21: 1239-1248, 2001


  12. Yamaguchi Y, Katoh H, Yasui H, Mori K, Negishi M: RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway. J Biol Chem 276: 18977-18983, 2001


  13. Haze K, Okada T, Yoshida H, Yanagi H, Yura T, Negishi M, Mori K: Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response. Biochem J 355: 19-28, 2001


  14. Choi S-Y, Choi B-H, Suh B-C, Chae H-D, Kim J-S, Shin M-J, Kang S-S, Negishi M, Kim K-T: Potentiation of PGE2-mediated cAMP production during neuronal differentiation of human neuroblastoma SK-N-BE(2)C cells. J Neurochem 79: 303-310, 2001


  15. Hatae N, Yamaoka K, Sugimoto Y, Negishi M, Ichikawa A: Augmentation of receptor-mediated adenylate cyclase activity by Gi-coupled prostaglandin receptor subtype EP3 in a Gβγ subunit-independent manner. Biochem Biophys Res Commun 290: 162-168, 2002


  16. Katoh H, Harada A, Mori K, Negishi M: Socius is a novel Rnd GTPases-interacting protein involved in disassembly of actin stress fibers. Mol Cell Biol 22: 2952-2964, 2002


  17. Nakamura K, Matsumura K, Kaneko T, Kobayashi S, Katoh H, Negishi M: The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area. J Neurosci 22: 4600-4611, 2002


  18. Tanaka H, Fujita H, Katoh H, Mori K, Negishi M: Vps4-A is a binding partner for a novel Rho family GTPase, Rnd2. Biochem J 365: 349-353, 2002


  19. Ishikawa Y, Katoh H, Nakamura K, Mori K, Negishi M: Developmental change in expression of small GTPase RhoG mRNA in the rat brain. Mol Brain Res 106: 145-150, 2002


  20. Yamaguchi Y, Katoh H, Mori K, Negishi M: Gα12 and Gα13 interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity. Curr Biol 12: 1353-1358, 2002


  21. Mouihate A, Clerget-Froidevaux M-S, Nakamura K, Negishi M, Wallace JL, Pittman QJ: Suppression of fever at near term is associated with reduced COX-2 protein expression in rat hypothalamus. Am J Physiol 283: R800-R805, 2002


  22. Okada T, Yoshida T, Akazawa R, Negishi M, Mori K: Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response. Biochem J 366: 585-594, 2002


  23. Fujita H, Katoh H, Ishikawa Y, Mori K, Negishi M: Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching. J Biol Chem 277: 45428-45434, 2002


  24. Yamaguchi Y, Katoh H, Negishi M: N-terminal short sequences of α subunits of G12 family determine selective coupling to receptors. J Biol Chem 278: 14936-14939, 2003


  25. Oinuma I, Katoh H, Harada A, Negishi M: Direct interaction of Rnd1 with Plexin-B1 regulates PDZ-RhoGEF-mediated Rho activation by Plexin-B1 and induces cell contraction in COS-7 cells. J Biol Chem 278: 25671-25677, 2003


  26. Katoh H, Negishi M: RhoG activates Rac1 through direct interaction with a Dock180-binding protein Elmo. Nature 424: 461-464, 2003


  27. Okada T, Haze K, Nadanaka S, Yoshida H, Seidah NG, Hirano Y, Sato R, Negishi M, Mori K: A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 278: 31024-31032, 2003


  28. Ishikawa Y, Katoh H, Negishi M: A role of Rnd1 GTPase in dendritic spine formation in hippocampal neurons. J Neurosci 23: 11065-11072, 2003


  29. Kakimoto T, Katoh H, Negishi M: Identification of splicing variants of Rapostlin, a novel Rnd2 effector interacting with N-WASP and inducing neurite branching. J Biol Chem 279: 14104-14110, 2004


  30. Sakai Y, Hashimoto H, Shintani N, Katoh H, Negishi M, Kawaguchi C, Kasai A, Baba A: PACAP activates Rac1 and synergizes with NGF to activate ERK1/2, thereby inducing neurite outgrowth in PC12 cells. Mol Brain Res 123: 18-26, 2004


  31. Shoji Y, Takahashi M, Kitamura T, Watanabe K, Kawamori T, Maruyama T, Sugimoto Y, Negishi M, Narumiya S, Sugimura T, Wakabayashi K: Downregulation of prostaglandin E receptor subtype EP3 during colon development. Gut 53: 1151-1158, 2004


  32. Oinuma I, Ishikawa Y, Katoh H, Negishi M: The semaphorin 4D receptor Plexin-B1 is a GTPase activating protein for R-Ras. Science 305: 862-865, 2004


  33. Oinuma I, Katoh H, Negishi M: Molecular dissection of the semaphorin 4D receptor Plexin-B1-stimulated R-Ras GAP activity and neurite remodeling in hippocampal neurons. J Neurosci 24: 11473-11480, 2004


  34. Harada A, Katoh H, Negishi M: Direct interaction of Rnd1 with FRS2b regulates Rnd1-induced downregulation of RhoA activity and is involved in FGF-induced neurite outgrowth in PC12 cells. J Biol Chem 280: 18418-18424, 2005


浜　千尋　（理化学研究所・発生・再生科学総合研究センター）
  1. Awasaki T, Saito M, Sone M, Suzuki E, Sakai R, Ito K, Hama C: The Drosophila Trio plays an essential role in patterning of axons by regulating their directional extension. Neuron 26: 119-131, 2000


  2. Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-Morimoto T, Yuasa Y, Yoshihara Y, Nose A, Okano H: The GAL4/UAS-WGA system as a powerful tool for tracing Drosophila transsynaptic neural pathways. J Neurosci Res 59: 94-99, 2000


  3. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata F, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C: Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168, 2000


  4. Saito M, Awasaki T, Hama C: Genetic analyses of essential genes in cytological region 61D1-2 to 61F1-2 of Drosophila melanogaster. Mol Gen Genomics 268: 446-454, 2002


  5. Orihara-Ono M, Suzuki E, Saito M, Yoda Y, Aigaki T, Hama C: The slender lobes gene, identified by retarded mushroom body development, is required for proper nucleolar organization in Drosophila.Dev Biol 281: 121-133, 2005


濱田　俊　（大阪大学・大学院生命機能研究科）
  1. Morishita H, Kawaguchi M, Murata Y, Seiwa C, Hamada S, Asou H, Yagi T: Myelination triggers down-regulation of axonal CNR/Protocadherin α family expression. Eur J Neurosci 20: 2843-2847, 2004


  2. Morishita H, Murata Y, Esumi S, Hamada S, Yagi T: CNR/Pcdhα family in subplate neurons, and developing cortical connectivity. NeuroReport 15: 2595-2599, 2004


  3. Murata Y, Hamada S, Morishita H, Mutoh T, Yagi T: Interaction with protocadherin-gamma regulates the cell-surface expression of protocadherin-alpha. J Biol Chem 279: 49508-49516, 2004


  4. Hamaguchi-Hamada K, Hamada S, Yagi T: Exposure to hexanal odor induces extraordinary Fos expression in the medial preoptic area and amygdala of Fyn tyrosine kinase-deficient mice. Mol Brain Res 130: 187-190, 2004


  5. Hamaguchi-Hamada K, Sanbo C, Hamada S, Yagi T: Exposure to hexanal odor influences maternal behavior and induces neonatal death in Fyn tyrosine kinase-deficient mice. Neurosci Res 48: 259-267, 2004


  6. Mutoh T, Hamada S, Senzaki K, Murata Y, Yagi T: Cadherin-related neuronal receptor 1 has cell-adhesion activity with beta1 integrin. Exp Cell Res 294: 494-508, 2004


  7. Sugino H, Yanase H, Hamada S, Kurokawa K, Asakawa S, Shimizu N, Yagi T: Distinct genomic sequence of the CNR/Pcdh α genes in chicken. Biochem Biophys Res Commun 316: 437-445, 2004


  8. Makino H, Yamazaki Y, Hirabayashi T, Kaneko R, Hamada S, Osada T, Kawamura Y, Yanagimachi R, Yagi T: Mouse embryos and chimera cloned from neural cells in the postnatal cerebral cortex.Cloning Stem Cells 7: 45-61, 2005


  9. Esumi S, Kakazu N, Taguchi Y, Hirayama T, Sasaki A, Hirabayashi T, Koide T, Kitsukawa T, Hamada S, Yagi T: Monoallelic yet combinatorial expression of variable exons of the CNR/protocadherin-α gene cluster in single neurons. Nat Genet 37: 171-176, 2005


  10. Ohsawa S, Hamada S, Kakinuma Y, Yagi T, MiuraM: A novel function of neuronal PAS domain protein 1 (NPAS1) in erythropoietin expression in neuronal cells. J Neurosci Res 79: 451-458, 2005


東島　眞一　（自然科学研究機構・岡崎統合バイオサイエンスセンター）
  1. Uemura O, Okada Y, Ando H, Guedj M, Higashijima S, Shimazaki T, Chino N, Okano H, Okamoto H: Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression. Dev Biol 278: 587-606, 2005


  2. Higashijima S, Mandel G, Fetcho JR: Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. J Comp Neurol 480: 1-18, 2004


  3. Higashijima S, Schaefer M, Fetcho JR: Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish.J Comp Neurol 480: 19-37, 2004


  4. Higashijima S, Masino M, Mandel G, Fetcho JR: Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron.J Neurosci 24: 5827-5839, 2004


  5. Li W-C, Higashijima S, Parry DM, Roberts A, Soffe SR: Primitive roles for inhibitory interneurons in developing frog spinal cord.J Neurosci 24: 5840-5848, 2004


等　誠司　（自然科学研究機構・生理学研究所）
  1. Kusunoki S, Morita D, Ohminami S, Hitoshi S, Kanazawa I: Binding of immunoglobulin G antibodies in Guillain-Barré syndrome sera to a mixture of GM1 and a phospholipids: possible clinical implications. Muscle Nerve 27: 302-306, 2003


  2. Hitoshi S, Seaberg RM, Koscik C, Alexon T, Kusunoki S, Kanazawa I, Tsuji S, van der Kooy D: Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling. Genes Dev 18: 1806-1811, 2004


古市　貞一　（理化学研究所・脳科学総合研究センター）
  1. Kagami Y, Furuichi T: Investigation of differentially expressed genes during the development of mouse cerebellum. Gene Expr Patterns 1: 39-59. 2001


  2. Bosanac I, Alattia JR, Mal TK, Chan J, Talarico S, Tong FK, Tong KI, Yoshikawa F, Furuichi T, Iwai M, Michikawa T, Mikoshiba K, Ikura M: Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420: 696-700, 2002


  3. Uchiyama T, Yoshikawa F, Hishida A, Furuichi T, Mikoshiba K: A novel recombinant hyperaffinity inositol 1,4,5-trisphosphate (IP3) absorbent traps IP3, resulting in specific inhibition of IP(3)-mediated calcium signaling. J Biol Chem 277: 8106-8113, 2002


  4. Iwasaki H, Chiba K, Uchiyama T, Yoshikawa F, Suzuki F, Ikeda M, Furuichi T, Mikoshiba K: Molecular characterization of the starfish inositol 1,4,5-trisphosphate receptor and its role during oocyte maturation and fertilization. J Biol Chem 277: 2763-2772, 2002


古川　貴久　（大坂バイオサイエンス研究所）
  1. Kuroda K, Han H, Tani S, Tanigaki K, Tun T, Furukawa T, Taniguchi Y, Kurooka H, Hamada Y, Toyokuni S, Honjo T: Regulation of Marginal Zone B Cell Development by MINT, a Suppressor of Notch/RBP-J Signaling Pathway. Immunity 18: 301-312, 2003


  2. Nishida A, Furukawa A, Koike C, Tano Y, Aizawa S, Matsuo I, Furukawa T: Otx2 homeobox gene controls retinal photoreceptor cell fate and pineal gland development. Nat Neurosci 6: 1255-1263, 2003


  3. Morrow EM, Furukawa T, Raviola E, Cepko CL: Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci 6: 5, 2005


  4. Kobashi-Hashida M, Ohguro N, Tsujikawa M, Furukawa T, Furukawa A, Hashida M, Tsujikawa K, Nakai K, Tano Y: Micro Serial Analysis of Gene Expression in Normal Human Choroid and Retinal Pigment Epithelial Transcriptomes. Jpn J Ophthalmol 49: 15-22, 2005


別所　康全　（京都大学・ウイルス研究所）
  1. Bae S, Bessho Y, Hojo M, Kageyama R: The bHLH gene Hes6, an inhibitor of Hes1, promotes neuronal differentiation. Development127: 2933-2943, 2000


  2. Hirata H, Ohtsuka T, Bessho Y, Kageyama R: Generation of structurally and functionally distinct factors from the basic helix-loop-helix gene Hes3 by alternative first exons. J Biol Chem 275: 19083-19089, 2000


  3. Bessho Y, Miyoshi G, Sakata R, Kageyama R: Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm. Genes Cells 6: 175-185, 2001


  4. Bessho Y, Sakata R, Komatsu S, Shiota K, Yamada S, Kageyama R: Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev 15: 2642-2647, 2001


  5. Hirata H, Tomita K, Bessho Y, Kageyama R: Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J 20: 4454-4466, 2001


  6. Inoue C, Bae SK, Takatsuka K, Inoue T, Bessho Y, Kageyama R: Math6, a bHLH gene expressed in the developing nervous system, regulates neuronal versus glial differentiation. Genes Cells 6: 977-986, 2001


  7. Satow T, Bae SK, Inoue T, Inoue C, Miyoshi G, Tomita K, Bessho Y, Hashimoto N, Kageyama R: The basic helix-loop-helix gene hesr2 promotes gliogenesis in mouse retina. J Neurosci 21: 1265-1273, 2001


  8. Hirata H, Yoshiura S, Ohtsuka T, Bessho Y, Harada T, Yoshikawa K, Kageyama R: Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science 298: 840-843, 2002


  9. Inoue T, Hojo M, Bessho Y, Tano Y, Lee JE, Kageyama R: Math3 and NeuroD regulate amacrine cell fate specification in the retina. Development 129: 831-842, 2002


星野　幹雄　（京都大学・大学院医学研究科）
  1. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C: Synaptic development is controlled in the periactive zones of Drosophila synapses. Development 127: 4157-4168, 2000


  2. Yoshizawa M, Hoshino M, Sone M, Nabeshima Y: Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain. Mech Dev 113: 65-68, 2002


  3. Matsuo N, Hoshino M, Yoshizawa M, Nabeshima Y: Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth. J Biol Chem 277: 2860-2868, 2002


前川　昌平　（神戸大学・大学院自然科学研究科）
  1. Uematsu A, Kumanogoh H, Yasaka K, Sokawa J, Orito A, Sokawa Y, Maekawa S: Specific localization of the vacuolar H+-ATPase in the Triton insoluble low-density fraction (raft) of bovine chromaffin granule membrane. J Biochem Mol Biol Biophys 4: 395-400, 2000


  2. Ohira K, Maekawa S, Hayashi M: Absence of trk B and insulin receptor β in the Triton insoluble low-density fraction (raft) of rat brain. NeuroReport 11: 1307-1311, 2000


  3. Funatsu N, Kumanogoh H, Sokawa Y, Maekawa S: Identification of gelsolin as a actin regulatory activity of a Triton insoluble low density fraction of bovine brain. Neurosci Res 36: 311-317, 2000


  4. Miyata S, Funatsu N, Matsunaga W, Kiyohara T, Sokawa Y, Maekawa S: Expression of the IgLON cell adhesion molecules, Kilon and OBCAM, in the hypothalamic magnocellular neurons. J Comp Neurol 424: 74-85, 2000


  5. Kashihara M, Miyata S, Kumanogoh H, Funatsu N, Matsunaga T, Kiyohara T, Sokawa Y, Maekawa S: Changes in the localization of NAP-22, a calmodulin binding membrane protein, during the development of neuronal polarity. Neurosci Res 327: 315-325, 2000


  6. Orito A, Kumanogoh H, Yasaka K, Sokawa J, Hidaka H, Sokawa Y, Maekawa S: Calcium-dependent association of annexin VI, protein kinase Cα, and neurocalcin α, on the raft fraction derived from the synaptic plasma membrane of rat brain. J Neurosci Res 64: 235-241, 2001


  7. Kumanogoh H, Miyata S, Sokwa Y, Maekawa S: Biochemical and morphological analysis on the localization of Rac1 in neurons. Neurosci Res 39: 189-196, 2001


  8. Maekawa S, Morii H, Kumanogoh H, Sano M, Naruse Y, Sokawa Y, Mori N: Localization of neuronal growth-assiciated microtubule-destabilizing factor SCG10 in brain-derived raft membrane microdomains. J Biochem 129: 691-697, 2001


  9. Miyata S, Takamatsu H, Maekawa S, Matsumoto N, Watanabe K, Kiyohara T, Hatton GI: Plasticity of neurophypophysial terminals with increased hormanal release during dehydration: ultrastructural and biochemical analyses. J Comp Neurol 434: 413-427, 2001


  10. Epand RM, Maekawa S, Yip CM, Epand RF: Protein-Induced formation of cholesterol-rich domains. Biochemistry 40: 10514-10521, 2001


水野　健作　（東北大学・大学院理学研究科）
  1. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya T, Mizuno K: Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. J Biol Chem 275: 3577-3582, 2000


  2. Bito H, Furuyashiki T, Ishihara H, Shibasaki Y, Ohashi K, Mizuno K, Maekawa M, Ishizaki T, Narumiya S: A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons. Neuron 26: 431-441, 2000


  3. Ohashi K, Hosoya T, Takahashi K, Hing H, Mizuno K: Drosophila LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization. Biochem Biophys Res Commun 276: 1178-1185, 2000


  4. Toshima JY, Toshima J, Watanabe T, Mizuno K: Binding of 14-3-3β regulates the kinase activity and subcellular localization of testicular protein kinase 1. J Biol Chem 276: 43471-43481, 2001


  5. Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K: LIM-kinase 2 induces formation of stress fibers, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalyzed phosphorylation at threonine-505. Biochem J 354: 149-159, 2001


  6. Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K: Cofilin phosphorylation by protein kinase TESK1 and its role in integrin-mediated actin reorganization and focal adhesion formation. Mol Biol Cell 12: 1131-1145, 2001


  7. Aizawa H, Wakatsuki S, Ishii A, Moriyama K, Sasaki Y, Ohashi K, Sekine-Aizawa Y, Sehara-Fujisawa A, Mizuno K,  Goshima Y, Yahara I: Phosphorylation of cofilin by LIM-kinase is necessary for semaphorin 3A-induced growth cone collapse. Nat Neurosci 4: 367-373, 2001


  8. Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K: Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells. J Biol Chem 276: 31449-31458, 2001


  9. Toshima J, Toshima JY, Suzuki M, Noda T, Mizuno K: Cell-type-specific expression of a TESK1 promoter-linked lacZ gene in transgenic mice. Biochem Biophys Res Commun 286: 566-573, 2001


村上　富士夫　（大阪大学・大学院生命機能研究科）
  1. Tashiro Y, Miyahara M, Shirasaki R, Okabe M, Heizmann CW, Murakami F: Local nonpermissive and oriented permissive cues guide vestibular axons to the cerebellum. Development 128: 973-981, 2001


  2. Sawamoto K, Nakao N, Kobayashi K, Matsushita N, Takahashi H, Kakishita K, Yamamoto A, Yoshizaki T, Terashima T, Murakami F, Itakura T, Okano H: Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons. Proc Natl Acad Sci USA 98: 6423-6428, 2001


  3. Shirasaki R, Murakami F: Crossing the floor plate triggers sharp turning of commissural axons. Dev Biol 236: 99-108, 2001


  4. Otsuka T, Murakami F, Song W-J: Excitatory postsynaptic potentials trigger a plateau potential in rat subthalamic neurons at hyperpolarized states. J Neurophysiol 86: 1816-1825, 2001


  5. Saito Y, Katsumaru H, Wilson CJ, Murakami F: Light and electron microscopic study of corticorubral synapses in adult cat：evidence for extensive synaptic remodeling during postnatal development. J Comp Neurol 440: 236-244, 2001


  6. Hatanaka Y, Murakami F: In vitro analysis of the origin, migratory behavior and maturation of cortical pyramidal cells. J Comp Neurol 454: 1-14, 2002


  7. Nagano T, Yoneda T, Hatanaka Y, Kubota C, Murakami F, Sato M: Filamin A-interacting protein FILIP regulates cortical cell migration out of the ventricular zone. Nat Cell Biol 4: 495-501, 2002


  8. Taniguchi H, Tamada A, Kennedy TE, Murakami F: Crossing the ventral midline causes neurons to change their response to floor plate and alar plate attractive cues during transmedian migration. Dev Biol 249: 321-332, 2002


  9. Takemoto M, Fukuda T, Sonoda R, Murakami F, Tanaka H, Yamamoto N: Ephrin-B3-EphA4 interactions regulate the growth of specific thalamocortical axon populations in vitro. Eur J Neurosci 16: 1168-1172, 2002


  10. Mizuseki K, Sakamoto T, Watanabe K, Muguruma K, Ikeya M, Nishiyama A, Arakawa A, Suemori H, Nakatsuji N, Kawasaki H, Murakami F, Sasai Y: Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc Natl Acad Sci USA 100: 5828-5833, 2003


  11. Miyahara M, Shirasaki R, Tashiro Y, Muguruma K, Heizmann CW, Murakami F: Pathfinding and growth termination of primary trigeminal sensory afferents in the embryonic rat hindbrain. J Comp Neurol 460: 503-513, 2003


  12. Hattori S, Murakami F, Song W-J: Rundown of a transient potassium current is attributable to changes in channel voltage dependence. Synapse 48: 57-65, 2003


  13. Kawauchi D, Kobayashi H, Sekine-Aizawa Y, Fujita SC, Murakami F: MuSC is involved in regulating axonal fasciculation of mouse primary vestibular afferents. Eur J Neurosci 18: 2244-2252, 2003


  14. Tanaka D, Nakaya Y, Yanagawa Y, Obata K, Murakami F: Multimodal tangential migration of neocortical GABAergic neurons independent of GPI-anchored proteins. Development 130: 5803-581, 2003


  15. Hattori S, Murakami F, Song W-J: Quantitative relationship between Kv4.2 mRNA and A-Type K+ current in rat striatal cholinergic interneurons during development. J Neurophysiol 90: 175-183, 2003


  16. Sabatier C, Plump AS, Ma L, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M: The divergent Robo family protein Rig-1/Robo3 is a negative regulator of Slit responsiveness required for midline crossing by commissural axons. Cell 117: 157-169, 2004


  17. Long H, Sabatier C, Ma L, Plump A, Yuan W, Ornitz D, Tamada A, Murakami F, Goodman CS, Tessier-Lavigne M: Conserved roles for Slit and Robo proteins in midline commissural axon guidance. Neuron 42: 213-223, 2004


  18. Hanamura K, Harada A, Katoh-Semba R, Murakami F, Yamamoto N: BDNF and NT-3 promote thalamocortical axon growth with distinct substrate and temporal dependency. Eur J Neurosci 19: 1485-1493, 2004


  19. Zhong Y, Takemoto M, Fukuda T, Hattori Y, Murakami F, Nakajima D, Nakayama M, Yamamoto N: Identification of the genes that are expressed in the upper layers of the neocortex. Cereb Cortex 14: 1144-1152, 2004


  20. Okabe N, Shimizu K, Ozaki-Kuroda K, Nakanishi H, Morimoto K, Takeuchi M, Katsumaru H, Murakami F, Takai Y: Contacts between the commissural axons and the floor plate cells are mediated by nectins. Dev Biol 273: 244-256, 2004


  21. Hatanaka Y, Hisanaga S, Heizmann CW, Murakami F: Distinct migratory behavior of early- and late-born neurons derived from the cortical ventricular zone. J Comp Neurol 479: 1-14, 2004


山本　融　（理化学研究所・発生・再生科学総合研究センター）
  1. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T: Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279: 24343-24354, 2004


横田　義史　（福井医科大学（現・福井大）・医学部）
  1. Yokota Y: Id and development. Oncogene, 20: 8290-8298, 2001


  2. Gleichmann M, Buchheim G, El-Bizri H, Yokota Y, Klockgether T, Köhler S, Bähr M, Weller M, Schulz JB: Identification of inhibitor-of-differentiation 2 (Id2) as a modulator of neuronal apoptosis. J Neurochem 80: 755-762, 2002


  3. Lasorella A, Boldrini R, Dominici C, Donfrancesco A, Yokota Y, Inserra A, Iavarone A: Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res 62: 301-306, 2002


  4. Yokota Y, Mori S: The role of Id family proteins in growth control. J Cell Physiol 190: 21-28, 2002


吉原　良浩　（理化学研究所・発生・脳科学総合研究センター）
  1. Mori K, von Campenhausen H, Yoshihara Y: Zonal organization of the mammalian main and accessory olfactory systems. Phil Trans R Soc Lond B 355: 1801-1812, 2000


  2. Nagao H, Yoshihara Y, Mitsui S, Fujisawa H, Mori K: Two mirror-image sensory maps with domain organization in the mouse main olfactory bulb. NeuroReport 11: 3023-3027, 2000


  3. Tian L, Nyman H, Kilgannon P, Yoshihara Y, Mori K, Andersson LC, Kaukinen S, Rauvala H, Gallatin MW, Gahmberg CG: Intercellular adhesion molecule-5 induces dendritic outgrowth by homophilic adhesion. J Cell Biol 50: 243-252, 2000


  4. Mori K, Nagao H, Yoshihara Y, Mizuno T: Sniffing out odors with multiple dendrites. Science 291: 835-837, 2001


  5. Mizuno T, Kawasaki M, Nakahira M, Kagamiyama H, Kikuchi Y, Okamoto H, Mori K, Yoshihara Y: Molecular diversity in zebrafish NCAM family: Three members with different VASE usage and distinct localization. Mol Cell Neurosci 18: 119-130, 2001


  6. Kinoshita N, Mizuno T, Yoshihara Y: Adenovirus-mediated WGA gene delivery for transsynaptic labeling of mouse olfactory pathways. Chem Senses 27: 215-223, 2002


  7. Yoshihara Y: Visualizing selective neural pathways with WGA transgene: combination of neuroanatomy with gene technology. Neurosci Res 44：133-140, 2002


  8. Nishiyori A, Hanno Y, Saito M, Yoshihara Y: Aberrant transcription of unrearranged T-cell receptor β gene in mouse brain. J Comp Neurol 469: 214-226, 2002


  9. Sapir T, Geiman EJ, Wang Z, Velasquez T, Mitsui S, Yoshihara Y, Frank E, Alvarez FJ, Goulding M: Pax6 and engrailed 1 regulate two distinct aspects of renshaw cell development. J Neurosci 24: 1255-1264, 2004


  10. Nagayama S, Takahashi YK, Yoshihara Y, Mori K: Mitral and tufted cells differ in the decoding manner of odor maps in the rat olfactory bulb. J Neurophysiol 91: 2532-2540, 2004


  11. Hasegawa S, Yamaguchi M, Nagao H, Yoshihara Y, Mori K: Activated natural killer cells adhere to cultured hippocampal neurons and affect the dendritic morphology. J Neuroimmunol 151: 126-136, 2004


  12. Inaki K, Nishimura S, Nakashiba T, Itohara S, Yoshihara Y: Laminar organization of the developing lateral olfactory tract revealed by differential expression of cell recognition molecules. J Comp Neurol 479: 243-256, 2004


  13. Inoue M, Nishimura S, Hori G, Nakahara H, Saito M, Yoshihara Y, Amari S: Improved parameter estimation for variance-stabilizing transformation of gene-expression microarray data. J Bioinf Comput Biol 2: 669-679, 2004


  14. Miyasaka N, Sato Y, Yoshihara Y: Axon guidance of olfactory sensory neurons in zebrafish. Chem Senses 30: i92-i93, 2005


  15. Mitsui S, Saito M, Hayashi K, Mori K, Yoshihara Y: A novel phenylalanine-based targeting signal directs telencephalin to neuronal dendrites. J Neurosci 25: 1122-1131, 2005


  16. Yoshihara S, Omichi K, Yanazawa M, Kitamura K, Yoshihara Y: Arx homeobox gene is essential for development of mouse olfactory system. Development 132: 751-762, 2005


  17. Miyasaka N, Sato Y, Yeo S, Hutson LD, Chien C, Okamoto H, Yoshihara Y: Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system. Development 132: 1283-1293, 2005


  18. Sato Y, Miyasaka N, Yoshihara Y: Mutually exclusive glomerular innervation by two distinct types of olfactory sensory neurons revealed in transgenic zebrafish. J Neurosci 25: 4889-4897, 2005


若松　義雄　（東北大学・大学院医学系研究科）
  1. Wakamatsu Y, Maynard TM, Weston JA: Fate determination of neural crest cells by NOTCH-mediated lateral inhibition and asymmetrical cell division during gangliogenesis. Development 127: 2811-2821, 2000


  2. Maynard TM, Wakamatsu Y, Weston JA: Cell interactions within nascent neural crest cell populations transiently promote death of neurogenic precursors. Development 127: 4561-4572, 2000


  3. Endo Y, Osumi N, Wakamatsu Y: Bimodal functions of Notch-mediated signaling are involved in neural crest formation during avian ectoderm development. Development 129: 863-873, 2002


  4. EndoY, Osumi N, Wakamatsu Y: Deltex/Dtx mediates NOTCH signaling in regulating Bmp4 expression for cranial neural crest formation during avian development. Dev Growth Differ 45: 241-248, 2003


  5. Wakamatsu Y, Endo Y, Osumi N, Weston JA: Multiple roles of Sox2, an HMG-box transcription factor in avian neural crest development. Dev Dyn 229: 74-86, 2004


  6. Wakamatsu Y, Osumi N, Weston JA: Expression of a novel secreted factor, Seraf indicates an early segregation of Schwann cell precursors from neural crest during avian development. Dev Biol 68: 162-73, 2004


  7. Matsuda Y, Wakamatsu Y, Kohyama J, Okano H, Fukuda K, Yasugi S: Notch signaling functions as a binary switch for the determination of glandular and luminal fates of endodermal epithelium during chicken stomach development. Development 132: 2783-2793, 2005


  8. Sakai D, Wakamatsu Y:Regulatory mechanisms for neural crest formation. Cells Tissues Organs 179: 24-35, 2005


  9. Sakai D, Tanaka Y, Endo Y, Osumi N, Okamoto H, Wakamatsu Y: Regulation of Slug transcription in embryonic ectoderm by β-catenin-Lef/Tcf and BMP-Smad signaling. Dev Growth Differ 47: 471-482, 2005

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