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  1. Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H: Synphilin-1 is present in Lewy bodies in Parkinsonfs disease. Ann Neurol 47: 521-523, 2000


  2. Yamada M, Piao Y-S, Toyoshima Y, Tsuji S, Takahashi H: Ubiquitinated filamentous inclusions in cerebellar dentate nucleus neurons in dentatorubral-pallidoluysian atrophy contain expanded polyglutamine stretches. Acta Neuropathol 99: 615-618, 2000


  3. Koide T, Yamada M, Takahashi T, Igarashi S, Masuko M, Furukawa T, Kuroha T, Koike T, Sato M, Tanaka R, Tsuji S, Takahashi H: Cyclosporine A-associated fatal central nervous system angiopathy in a bone marrow transplant recipient: an autopsy case. Acta Neuropathol 99: 680-684, 2000


  4. Shibasaki Y, Tanaka H, Iwabuchi K, Kawasaki S, Kondo H, Uekawa K, Ueda M, Kamiya T, Katayama Y, Nakamura A, Takashima H, Nakagawa M, Masuda M, Utsumi H, Nakamuro T, Tada K, Kurohara K, Inoue K, Koike F, Sakai T, Tsuji S, Kobayashi H: Linkage of autosomal recessive hereditary spastic paraplegia with mental impairment and thin corpus callosum to chromosome 15q13-15. Ann Neurol 48: 108-112, 2000


  5. Yamashita I, Sasaki H, Yabe I, Fukazawa T, Nogoshi S, Komeichi K, Takada A, Shiraishi K, Takiyama Y, Nishizawa M, Kaneko J, Tanaka H, Tsuji S, Tashiro K: A novel locus for dominant cerebellar ataxia (SCA14) maps to a 10.2-cM interval flanked by D19S206 and D19S605 on chromosome 19q13.4-qter. Ann Neurol 48: 156-163, 2000


  6. Maruyama M, Ikeuchi T, Saito M, Ishikawa A, Yuasa T, Tanaka H, Hayashi S, Wakabayashi K, Takahashi H, Tsuji S: Novel mutations, pseudo-dominant inheritance, and possible familial affects in patients with autosomal recessive juvenile parkinsonism. Ann Neurol 48: 245-250, 2000


  7. Takano H, Koike R, Onodera O, Tsuji S.: Mutational analysis of X-linked adrenoleukodystrophy gene. Cell Biochem Biophys 32: 177-185, 2000


  8. Shimohata T, Nakajima T, Yamada M, Uchida C, Onodera O, Naruse S, Kimura T, Koide R, Nozaki K, Sano Y, Ishiguro H, Sakoe K, Ooshima T, Sato A, Ikeuchi T, Oyake M, Sato T, Aoyagi Y, Hozumi I, Nagatsu T, Takiyama Y, Nishizawa M, Goto J, Kanazawa I, Davidson I, Tanese N, Takahashi H, Tsuji S: Expanded polyglutamine stretches associated with CAG repeat diseases interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet 26: 29-35, 2000


  9. Tsuchiya K, Shintani S, Nakabayashi H, Kikugawa K, Nakano R, Haga C, Nakano I, Ikeda K, Tsuji S: Familial amyotrophic lateral sclerosis with onset in bulbar sign, benign clinical course, and Bunina bodies: a clinical, genetic, and pathological study of a Japanese family. Acta Neuropathol 100: 603-607, 2000


  10. Hayashi S, Wakabayashi L, Ishikawa A, Nagai H, Saito M, Maruyama M, Takahashi T, Ozawa T, Tsuji S, Takahashi H: An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene. Mov Disord 15: 884-888, 2000


  11. Shimohata T, Onodera O, Tsuji S: Interaction of expanded polyglutamine stretches with nuclear transcription factors leads to aberrant transcriptional regulation in polyglutamine diseases. Neuropathology 20: 326-333, 2000


  12. Yamada M, Wood JD, Shimohata T, Hayashi S, Tsuji S, Ross CA, Takahashi H: Widespread occurrence of intranuclear atrophin-1 accumulation in the central nervous system neurons of patients with dentatorubral-pallidoluysian atrophy. Ann Neurol 49: 14-23, 2001


  13. Gaspar C, Lopes-Cendes I, Hayes S, Goto J, Arvidsson K, Dias A, Silveira I, Maciel P, Coutinho P, Lima M, Zhou Y-X, Soong B-W, Watanabe M, Giunti P, Stevanin G, Riess O, Sasaki H, Hsieh M, Nicholson GA, Brunt E, Higgins JJ, Lauritzen M, Tranebjaerg L, Volpini V, Wood N, Ranum L, Tsuji S, Brice A, Sequeiros J, Rouleau GA: Ancestral origins of the Machado-Joseph disease mutation: A worldwide haplotype study. Am J Hum Genet 68: 523-528, 2001


  14. Yamada M, Hayashi S, Tsuji S, Takahashi H: Involvement of the cerebral cortex and autonomic ganglia in Machado-Joseph disease. Acta Neuropathol 101: 140-144, 2001


  15. Kawachi I, Nozaki H, Watanabe M, Sato A, Tsuji S: Spontaneous spinal cord herniation. Neurology 56: 977, 2001


  16. Shimohata T, Onodera O, Tsuji S: Expanded polyglutamine stretches lead to aberrant transcriptional regulation in polyglutamine diseases. Hum Cell 14: 17-25, 2001


  17. Nakamura K, Jeong SE, Uchihara T, Anno M, Nagashima K, Nagashima T, Ikeda S, Tsuji S, Kanazawa I: SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet 10: 1441-1448, 2001


  18. Sekine M, Nagata H, Tsuji S, Hirai Y, Fujimoto S, Hata M, Kobayashi I, Fujii T, Nagata I, Ushijima K, Obata K, Suzuki, M, Yoshinaga M, Umesaki N, Sato S, Enomoto T, Motoyama S, Tanaka K: The Japanese familial ovarian cancer study group: Localization of a novel susceptibility gene for familial ovarian cancer to chromosome 3p22-p25. Hum Mol Genet 10: 1421-1429, 2001


  19. Date H, Onodera O, Tanaka H, Iwabuchi K, Uekawa K, Igarashi S, Koike R, Hiroi T, Yuasa T, Awaya Y, Sakai T, Takahashi T, Nagatomo H, Sekijima Y, Kawachi I, Takiyama Y, Nishizawa M, Fukuhara N, SaitoK, Sugano S, Tsuji S: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat Genet 29: 184-188, 2001


  20. Yamada M, Sato T, Shimohata T, Hayashi S, Igarashi S, Tsuji S, Takahashi H: Interaction between neuronal intranuclear inclusions and promyelocytic leukemia protein nuclear and coiled bodies in CAG repeat diseases. Am J Pathol 159: 1785-1795, 2001


  21. Takahashi H, Egawa H, Piao Y-S, Hayashi S, Yamada M, Shimohata T, Oyanagi K, Tsuji S: Brain Res 919: 12-19, 2001


  22. Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H: Immunocytochemical localization of synphilin-1, an a-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathol 103: 209-214, 2001


  23. Nozaki K, Onodera O, Takano H, Tsuji S: Amino acid sequences flanking polyglutamine stretches influence their potential for aggregate formation. NeuroReport 12: 3357-3364, 2001


  24. Asaka T, Ikeuchi K, Okino S, Takizawa Y, Satake R, Nitta E, Komai K, Endo K, Higuchi S, Oyake T, Yoshimura T, Suenaga A, Uyam E, Saito T, Konagaya M, Sunohara N, Namba R, Takada H, Honke K, Nishina M, Tanaka H, Shinagawa M, Tanaka K, Matsushima A, Tsuji S, Takamori M: Homozygosity and linkage disequilibrium mapping of autosomal recessive distal myopathy (Nonaka distal myopathy). J Hum Genet 46: 649-655, 2001


  25. Nucifora FC Jr, Sasaki M, Peters MF, Huang H, Cooper JK, Yamada, M, Takahashi H, Tsuji S, Troncoso J, Dawson VL, Dawson, TM, Ross CA: Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science 291: 2423-2428, 2001


  26. Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F: A new locus for Parkinsonfs disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol 51: 296-301, 2002


  27. Takahashi T, Igarashi S, Kimura T, Hozumi I, Kawachi I, Onodera O, Takano H, Saito M, Tsuji S: Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene. J Neurol Neurosurg Psychiat 72: 675-680, 2002


  28. Toyoshima I, Sugawara M, Kato K, Wada C, Shimohata T, Koide R, Onodera O, Tsuji S: Time course of polyglutamine aggregate body formation and cell death: Enhanced growth in nucleus and an interval for cell death. J Neurosci Res 68: 442-448, 2002


  29. Shimohata T, Sato A, Burke JR, Strittmatter WJ, Tsuji S, Onodera O: Expanded polyglutamine stretchers form an eaggresomef. Neurosci Lett 323: 215-218, 2002


  30. Shimazaki H, Takiyama Y, Sakoe K, Ikeguchi K, Niijima K, Kaneko J, Namekawa M, Ogawa T, Date H, Tsuji S, Nakano I, Nishizawa M: Early-onset ataxia with ocular motor apraxia and hypoalbuminemia. Neurology 59: 590-595, 2002


  31. Arai A, Tanaka K, Igarashi S, Kobayashi H, Asaka T, Date H, Saito M, Tanaka H, Kawasaki S, Uyama E, Mizusawa H, Fukuhara N, Tsuji S: A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees. Ann Neurol 52: 516-519, 2002


  32. Silveria I, Miranda C, Guimarães L, Moreira M-C, Alonso I, Mendonça P, Ferro A, Pinto-Basto J, Coelho J, Ferreirinha F, Poirier J, Parreira E, Vale J, Januário C, Barbot C, Tuna A, Barros J, Koide R, Tsuji S, Holmes SE, Margolis RL, Jardim L, Pandolfo M, Coutinho P, Sequeiros J: Trinucleotide repeats in 202 families with ataxia. A small expanded (CAG)n allele at the SCA17 locus. Arch Neurol 59: 623-629, 2002


  33. Ikeuchi T, Nomura Y, Segawa M, Ozelius LJ, Shimohata T, Tsuji S: Multiple founder effects in Japanese families with primary torsion dystonia harboring the GAG deletion in the Tor1A (DYT1) gene. Neurogenetics 4: 105-106, 2002


  34. Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H: Immunocytochemical localization of synphilin-1, an α-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathol 103: 209-214, 2002


  35. Yamada M, Sato T, Tsuji S, Takahashi H: Oligodendrocytic polyglutamine pathology in dentatorubral-pallidoluysian atrophy. Ann Neurol 52: 670-674, 2002


  36. Yamada M, Tsuji S, Takahashi H: Involvement of lysosomes in the pathogenesis of CAG repeat diseases. Ann Neurol 52: 498-503, 2002


  37. Yamada M, Tsuji S, Takahashi H: Genotype-phenotype correlation in CAG-repeat diseases. Neuropathology 22: 317-322, 2002


  38. Iwata A, Maruyama M, Akagi T, Hashikawa T, Kanazawa I, Tsuji S, Nukina N: Alpha-synuclein degradation by serine protease neurosin: Implication for pathogenesis of synucleinopathies. Hum Mol Genet 12: 2625-2635, 2003


  39. Sanpei K, Ikeuchi T, Tsuji S: DIRECT technologies for molecular cloning of genes containing expanded CAG repeats. Methods Mol Biol 217: 73-81, 2003


  40. Sekijima Y, Hashimoto T, Onodera O, Date H, Okano T, Naito K, Tsuji S, Ikeda S: Severe generalized dystonia as a presentation of a patient with aprataxin gene mutation. Mov Disord 18: 1198-1200, 2003


  41. Yabe I, Sasaki H, Chen DH, Raskind WH, Bird TD, Yamashita I, Tsuji S, Kikuchi S, Tashiro K: Spinocerebellar ataxia type 14 caused by a mutation in protein kinase C gamma. Arch Neurol 60: 1749-1751, 2003


  42. Shimohata T, Kimura T, Nishizawa M, Onodera O, Tsuji S: Five year follow up of a patient with spinal and bulbar muscular atrophy treated with leuprorelin. J Neurol Neurosurg Psychiat 75: 1206-207, 2004


  43. Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S: Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a nucleotide repair protein. Ann Neurol 55: 241-249, 2004


  44. Züchner S, Mersiyanova IV, Muglia M, Bissar-Tadmouri N, Rochelle J, Dadali EL, Zappia M, Nelis E, Patitucci A, Senderek J,. Parman Y,. Evgrafov O, Jonghe PD, Takahashi Y, Tsuji S, Pericak-Vance MA, Quattrone A, Battaloglu E, Polyakov AV, Timmerman V, Schröder JM, Vance JM, Battologlu E: Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A. Nat Genet 36: 449-451, 2004


  45. Yamada M, Tan S-H, Inenaga C, Tsuji S, Takahashi H: Sharing of polyglutamine transport by the neuronal nucleus and cytoplasm in CAG-repeat diseases. Neuropathol Appl Neurobiol 30: 665-675, 2004


  46. Date H, Igarashi S, Sano Y, Takahashi T, Takahashi T, Takano H, Tsuji S, Nishizawa S, Onodera O: The FHA domain of aprataxin (APTX) interacts with the C terminal region of XRCC1. Biochem Biophys Res Commun 325: 1279-1285, 2004


  47. Shimohata M, Shimohata T, Igarashi S, Naruse S, Tsuji S: Interference of CREB-dependent transcriptional activation by expanded polyglutamine stretches - Augmentation of transcriptional activation as a potential therapeutic strategy for polyglutamine diseases. J Neurochem 93: 654-663, 2005


؁@Ё@(wEw@wn)
  1. Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle P, Haass C: Constitutive phosphorylation of the Parkinsonfs disease associated α-synuclein. J Biol Chem 275: 390-397, 2000


  2. Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H: Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disese) with diffuse neurofibrillary and Lewy body pathology. Acta Neuropathol 99: 331-336, 2000


  3. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-calpain. Int J Mol Med 5: 269-273, 2000


  4. Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T: Molecular cloning and characterization of a novel CLIC-related protein, parchorin, expressed in water-secreting cells. J Biol Chem 275: 11164-11173, 2000


  5. Yasuda M, Takamatsu J, DfSouza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Iwatsubo T, Goedert M, Schellenberg G, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47: 422-429, 2000


  6. Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of tau gene. Neurology 54: 1787-1795, 2000


  7. Saura CA, Tomita T, Soriano S, Takahashi M, Leem J-Y, Honda T, Koo EH, Iwatsubo T, Thinakaran G: The non-conserved hydrophilic loop domain of presenilin is neither required for presenilin endoproteolysis nor enhanced Aβ42 production mediated by FAD-linked PS variants. J Biol Chem275: 17136-17142, 2000


  8. Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Downfs syndrome. Alz Rep 3: 77-82, 2000


  9. Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M,Mann DMA, Hyman BT, Iwatsubo T: Age-related amyloid b deposition in transgenic mice overexpressing both presenilin 1 and amyloid β precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol157: 331-339, 2000


  10. Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi K: α-Synuclein inclusions in amygdala in the brains of patients with Parkinsonism-Dementia Complex of Guam. J Neuropathol Exp Neurol 59: 585-591, 2000


  11. Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi S, Morit T, Iwatsubo T, Takahashi H: Primary progressive aphasia with focal glial tauopathy. Neuropathol Appl Neurobiol 26: 477-481, 2000


  12. Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin MC: A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer's disease but not with Aβ loading in brains. Neurosci Lett 293: 29-32, 2000


  13. Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim S-H, Thinakaran G, Sisodia SS, Snyder SH: Amyloid precursor proteins inhibit heme oxygenase activity and augument neurotoxicity in Alzheimerfs disease. Neuron 28: 461-473, 2000


  14. Pickering-Brown S, Baker M, Yen S-H, Liu W-K, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, Hutton M: Pickfs disease is associated with mutations in the tau gene. Ann Neurol 48: 859-867, 2000


  15. Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS Lett 489: 46-50, 2001


  16. Lee J-A, Long Z, Nimura N, Iwatsubo T, Imai K, Homma H: Localization, transport, and uptake of D-aspartate in the rat adrenal and pituitary glands. Arch Biochem Biophys 385: 242-249, 2001


  17. Lambert J-C, Mann D, Goumidi L, Harris J, Amouyel P, Iwatsubo T, Lendon CL, Chartier-Harlin M-C: Effect of the APOE promoter polymorphisms on cerebral amyloid peptide deposition in Alzheimerfs disease. Lancet 357: 608-609, 2001


  18. Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y: Molecular cloning and expression of the novel splice variants of K+ channel-interacting protein 2 (KChIP2). Biochem Biophys Res Commun 282: 96-102, 2001


  19. Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi T: Co-localization of a-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 101: 285-293, 2001


  20. Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol 49: 501-511, 2001


  21. Mann DMA, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T: Amyloid β protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neurosci Lett 304: 161-164, 2001


  22. Verkkoniemi A, Kalimo H, Paetau A, Somer M, Iwatsubo T, Hardy J, Haltia M: Variant Alzheimerfs disease with spastic paraparesis: Neuropathological phenotype. J Neuropathol Exp Neurol 60: 483-492, 2001


  23. Mann DMA, Pickering-Brown SM, Takeuchi A,Iwatsubo T:Amyloid angiopathy and variability in amyloid β deposition is determined by mutation position in presenilin-1 linked Alzheimerfs disease. Am J Pathol 158: 2165-2175, 2001


  24. Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptide 1-40 and 1-42 most effectively among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276: 21895-21901, 2001


  25. Iwata H, Tomita T, Maruyama K, Iwatsubo T: Subcellular compartment and molecular subdomain of β-amyloid precursor protein relevant to the Aβ42-promoting effects of Alzheimer mutant presenilin 2. J Biol Chem 276: 21678-21685, 2001


  26. Lambert J-C, Mann D, Harris JM, Chartier-Harlin M-C, Cummings A, Coates J, Lemmon H, St-Clair D, Iwatsubo T, Lendon C: The -48 CT polymorphism in the presenilin 1 promoter is associated with an increased risk of developing Alzheimerfs disease and an increased Aβ load in brain. J Med Genet 38: 353-355, 2001


  27. Mann DMA, Takeuchi A, Sato S, Cairns NJ, Lantos PL, Rossor MN, Haltia M, Kalimo H, Iwatsubo T: Cases of Alzheimerfs disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic β amyloid pathology known as gcotton woolh plaques. Neuropathol Applied Neurobiol 27: 189-196, 2001


  28. Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309: 89-92, 2001


  29. Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T: The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation and γ-secretase activities of presenilins. J Biol Chem 276: 33273-33281, 2001


  30. Kahle PJ, Neumann M, OzmenL, MüllerV, Odoy S, JacobsenH, IwatsuboT, TrojanowskiJQ, TakahashiH, Wakabayashi K, BogdanovicN, RiedererP, KretzschmarHA, Haass C: Selective insolubility of α-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159: 2215-2225, 2001


  31. Ikegaya YM, Kim J-A, Baba M, Iwatsubo T, Nishiyama N, Matsuki N: Rapid and reversible changes in dendrite morphology and synaptic efficacy following NMDA receptor activation: Implication for a cellular defense against excitotoxicity. J Cell Sci 114: 4083-4093, 2001


  32. Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T: α-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4: 160-164, 2002


  33. Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T: CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J 21: 1524-1534, 2002


  34. Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51: 525-530, 2002


  35. Lambert J-C, Thaker U, Green EK, Harris JM, McDonagh AM, Iwatsubo T, Chartier-Harlin MC, Pickering-Brown SM, Lendon CL, Mann DMA: The -48 C/T polymorphism within the promotor region of the presenilin-1 gene does not influence the extent of tau pathology within the brain in sporadic Alzheimerfs disease. Alz Rep 5: 13-16, 2002


  36. Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 277: 14965-14975, 2002


  37. Miake H, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002


  38. Green EK, Thaker U, McDonagh AM, Iwatsubo T, Lambert JC, Chartier-Harlin MC, Harris JM, Pickering-Brown SM, Lendon CL, Mann DMA: A polymorphism within intron 11 of the tau gene is not increased in frequency in patients with sporadic Alzheimer's disease, nor does it influence the extent of tau pathology in the brain. Neurosci Lett 324: 113-116, 2002


  39. Tomita T, Katayama R, Takikawa R, Iwatsubo T: Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS Lett 520: 117-121, 2002


  40. Green EK, Harris JM, Lemmon H, Lambert JC, Chartier-Harlin MC, St Clair D, Mann DMA, Iwatsubo T, Lendon CL:Are interleukin-1 gene polymorphisms risk factors or disease modifiers in Alzheimerfs disease. Neurology 58: 1566-1568, 2002


  41. Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C: Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 3: 583-588, 2002


  42. Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294: 429-440, 2002


  43. Araria-Goumidi L, Lambert JC, Mann DMA, Lendon C, Frigard B, Iwatsubo T, Cottel D, Amouyel P, Chartier-Harlin MC: Association study of three polymorphisms of TGF-β1 gene with Alzheimerfs disease. J Neurol Neurosurg Psychiat 73: 62-64, 2002


  44. Lendon CL, Thaker U, Harris JM, McDonagh AM, Lambert JC, Chartier-Harlin MC, Iwatsubo T, Pickering-Brown SM, Mann DMA: The angiotensin 1-converting enzyme insertion (I)/deletion (D) polymorphism does not influence the extent of amyloid or tau pathology in patients with sporadic Alzheimerfs disease. Neurosci Lett 328: 314-318, 2002


  45. Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neurosci Lett 330: 84-88, 2002


  46. OkochiM, SteinerH, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Haass C, Takeda M: Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1. EMBO J 21: 5408-5416, 2002


  47. Watanabe T, Nakagawa K, Ohata S, Kitagawa D, Nishitai G, Seo J, Tanemura S, Shimizu N, Kishimoto H, Wada T, Aoki J, Arai H, Iwatsubo T, Mochita M, Watanabe T, Satake M, Ito Y, Matsuyama T, Mak TW, Penninger JM, Nishina H, Katada T: SEK1/MKK4-mediated SAPK/JNK signaling participates in embryonic hepatoblast proliferation via a pathway different from NF-kB-induced anti-apoptosis. Dev Biol250: 332-347, 2002


  48. Hayes A, Thakera U, Iwatsubo T, Pickering-Brown SM, Mann DMA: Pathological relationships between microglial cell activity and tau and amyloid β protein in patients with Alzheimerfs disease.Neurosci Lett 331: 171-174, 2002


  49. Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi Matsui T, Murayama M, Iwatsubo T, Higuchi S: Clinical and biomarker investigation of a patient with a novel PS-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimerfs disease. Biol Psychiat 52: 907-910, 2002


  50. Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J Clin Invest 110: 1429-1439, 2002


  51. Leem JY, Saura CA, Pietrzik C, Kim S-H, Veselits ML, Christianson J, Wanamaker C, Tomita T, Gasparini L, Iwatsubo T, Xu H, Green WN, Koo E-H, Thinakaran G: A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 11: 64-82, 2002


  52. Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann DMA, Iwatsubo T: Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002


  53. Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T: The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem 277: 50198-50205, 2002


  54. Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila. Neurosci Lett 336: 155-158, 2003


  55. Thaker U, McDonagh AM, Iwatsubo T, Lendon CL, Pickering-Brown SM, Mann DMA: Tau load is associated with apolipoprotein E genotype and the amount of amyloid β protein Aβ40 in sporadic and familial Alzheimerfs disease. Neuropathol Appl Neurobiol 29: 35-44, 2003


  56. Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H: Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44.Oncogene 22: 1511-1516, 2003


  57. Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422: 438-441, 2003


  58. Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R: APP processing and synaptic function. Neuron 37: 925-937, 2003


  59. Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide is a non-competitive γ-secretase inhibitor that preferentially reduces Aβ42 generation. J Biol Chem 278: 18664-18670, 2003


  60. Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropathol Exp Neurol 62: 644-654, 2003


  61. Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: α-synuclein accumulates in purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003


  62. Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I: Analysis of neurons created from wild-type and Alzheimerfs mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J Neurosci 23: 8513-8525, 2003


  63. Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chem Commun 17: 2244-2245, 2003


  64. Schroeter EH, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-M, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R: A presenilin dimer at the core of the γ-secretase enzyme? Insights from parallel analysis of Notch 1 and APP proteolysis.Proc Natl Acad Sci USA 100: 13075-13080, 2003


  65. Soderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM-Y, Trojanowski JQ, Naslund J: Molecular identification of AMY, and Alzheimer disease amyloid-associated protein. J Neuropathol Exp Neurol 62: 1108-1117, 2003


  66. Taniguchi S, McDonaghAM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathol Appl Neurol 30: 1-18, 2004


  67. Matsubayashi H, Sese S, Lee J-S, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S-i: Biochemical characterization of Drosophila Wingless signaling pathway based on RNA interference. MolCell Biol 24: 2012-2024, 2004


  68. Lambert JC, Mann D, Harris J, Araria-Goumidi L, Chartier-Harlin MC, Cottel D, Iwatsubo T, Amouyel P, Lendon C: Association study of Notch 4 polymorphisms with Alzheimerfs disease. J Neurol Neurosurg Psychiat 75: 377-381, 2004


  69. Tanaka M, Kim YM, Lee G, Junn E, Iwatsubo T, Mouradian M: Aggresomes formed by α-synuclein and synphilin-1 are cytoprotective. J Biol Chem 279: 4625-4631, 2004


  70. Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H: Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of w-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues. Tetrahedron Lett 45: 2323-2396, 2004


  71. Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: Accumulation of phosphorylated α-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 107: 292-298, 2004


  72. Umeda Y, Taniguchi S, Arima K, Piao Y-SH, Takahashi H, Iwatsubo T, Mann D, Hasegawa M: Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neurosci Lett 359: 151-154, 2004


  73. Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity. Bioorg Med Chem Lett 14: 1983-1985, 2004


  74. Busby V, Goossens S, Nowotny P, Hamilton G, Smemo S, Harold D, Turic D, Jehu L, Myers A, Womick M, Woo D, Compton D, Doil LM, Tacey KM, Lau KF, Al-Saraj S, Killick R, Pickering-Brown S, Moore P, Hollingworth P, Archer N, Foy C, Walter S, Lendon C, Iwatsubo T, Morris JC, Norton J, Mann D, Janssens B, Hardy J, OfDonovan M, Jones L, Williams J, Holmans P, Owen MJ, Grupe A, Powell J, van Hengel J, Goate A, Van Roy F, Lovestone S: α-T-catenin is expressed in human brain and interacts with the Wnt signalling pathway but is not responsible for linkage to chromosome 10 in Alzheimerfs disease. Neuromolecular Med 5: 133-146, 2004


  75. Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K: Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimerfs disease in aged mice. Eur J Neurosci 19: 2826-2838, 2004


  76. Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor protein missense mutation (D678N) in familial Alzheimerfs disease. J Neurol Neurosurg Psychiat 75: 1039-1042, 2004


  77. Zhang Y, Hayes A, Pritchard A, Haque MS, Lemmon H, Harris J, Cumming A, Lambert JC, Chartier-Harlin MC, St Clair D, Iwatsubo T, Mann DM, Lendon CL: Interleukin-6 promoter polymorphism: risk and pathology of Alzheimerfs disease. Neurosci Lett 362: 99-102, 2004


  78. Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DMA, Duf K, Tsuji S, Hashimoto T, Iwatsubo T: Mostly separate distributions of CLAC- versus Aβ40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of β-amyloid deposits. Am J Pathol 165: 273-281, 2004


  79. Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H: Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation. J Cell Biol 165: 893-902, 2004


  80. Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M: Phosphorylated α-synuclein in normal mouse brain. FEBS Lett 572: 227-232, 2004


  81. Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T: Selective reconstitution and recovery of functional γ-secretase complex on budded baculovirus particles. J Biol Chem 279: 38040-38046, 2004


  82. Yamada M, Iwatsubo T, Mizuno Y, Mochizuki H: Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9. Resemblance to pathogenetic changes in Parkinsonfs disease. J Neurochem 91: 451-461, 2004


  83. Lo Bianco C, Schneider BL, Bauer M, Sajadi A, Brice A, Iwatsubo T, Aebischer P: Lentiviral vector delivery of parkin prevents dopaminergic degeneration in an α-synuclein rat model of Parkinsonfs disease. Proc Natl Acad Sci USA 101: 17510-17515, 2004


  84. Nonaka T, Iwatsubo T, Hasegawa M: Ubiquitination of α-synuclein. Biochemistry 44: 361-368, 2005


  85. Taniguchi S, Suzuki N, Masuda M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M: Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins. J Biol Chem 280: 7614-7623, 2005


  86. Osada Y, Hashimoto T, Nishimura A, Matsuo Y, Wakabayashi T, Iwatsubo T: CLAC binds to amyloid β peptides through the positively-charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils. J Biol Chem 280: 8596-8605, 2005


  87. Niimura M, Isoo N, Takasugi N, Tsuruoka M, Tei-Ui K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T: Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter- and intramolecular interactions. J Biol Chem 280: 12967-12975, 2005


  88. Urano Y, Hayashi I, Isoo N, Reid PC, Shibasaki Y, Noguchi N, Tomita T, Iwatsubo T, Hamakubo T, Kodama T: Association of active γ-secretase complex with lipid rafts. J Lipid Res 46: 904-912, 2005


  89. Iseki E, Marui W, Yamamoto R, Togo T, Katsuse O, Kato M, Iwatsubo T, Kosaka K, Arai H: The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies. Neurosci Lett 380: 161-165, 2005


  90. Machida Y, Chiba T, Takayanagi A, Tanaka Y, Asanuma M, Ogawa N, Koyama A, Iwatsubo T, Ito S, Jansen PH, Shimizu N, Tanaka K, Mizuno Y, Hattori N: Common anti-apoptotic roles of parkin and α-synuclein in human dopaminergic cells. Biochem Biophys Res Commun 332: 233-240, 2005


  91. Pritchard A, Harris J, Pritchard CW, St Clair D, Lemmon H, Lambert JC, Chartier-Harlin MC, Hayes A, Thaker U, Iwatsubo T, Mann DM, Lendon C: Association study and meta-analysis of low-density lipoprotein receptor related protein in Alzheimerfs disease. Neurosci Lett 382: 221-226, 2005


  92. Smith WW, Margolis RL, Li X, Troncoso JC, Lee MK, Dawson VL, Dawson TM, Iwatsubo T, Ross CA: α-Synuclein phosphorylation enhances Lewy body-like inclusion formation in SH-SY5Y cells. J Neurosci 25: 5544-5552, 2005


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  1. Mizuno K, Wakai M, Takeda A, Sobue G: Medial temporal atrophy and memory impairment in early stage of Alzhermerfs disease: an MRI volumetric and memory assessment study. J Neurol Sci 173: 18-24, 2000


  2. Takeuchi H, Misu K, Hattori N, Nagamatsu M, Sobue G: Immunoglobulin therapy for idiopathic chronic sensory ataxic neuropathy. Neurology 54: 1008-1010, 2000


  3. Kobayashi Y, Kume A, Li M, Doyu M, HataM, Ohtsuka K, Sobue G: Chaperones, Hsp70 and Hsp40, suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 275: 8772-8778, 2000


  4. Inukai A, Kuru S, Liang Y, Takano A, Kobayashi Y, Sakai M, Doyu M, Sobue G: Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis. Muscle Nerve 23: 385-392, 2000


  5. Mutoh T, Sobue G, Hamano T, Kuriyama M, Hirayama M, Yamamoto M, Mitsuma T: Decreased phosphorylation levels of TrkB neurotrophin receptor in the spinal cords from patients with amyotrophic lateral sclerosis. Neurochem Res 25: 239-245, 2000


  6. Kuru S, Inukai A, Liang Y, Doyu M, Takano A, Sobue G: Tumor necrosis factor-α expression in muscles of polymyositis and dermatomositis. Acta Neuropathol 99: 585-588, 2000


  7. Takano A, Bönneman CG, Honda H, Sakai M, Feener CA, Kunkel LM, Sobue G: Intrafamilial phenotype variation in limb-girdle muscular dystrophy type 2c with compound heterozygous mutations. Muscle Nerve 23: 807-810, 2000


  8. Terao S, Takeda A, Miura N, Izumi M, Ito E., Mitsuma T, Sobue G: Clinical and pathophysiological features of amaurosis fugax in Japanese stroke patients. Intern Med 39: 118-122, 2000


  9. Yoshihara T, Yamamoto M, Doyu M, Misu K, Hattori N, Hasegawa Y, Mokuno K, Mitsuma T, Sobue G: Mutations in the peripheral myelin protein zero and connexin 32 genes detected by non-isotopic RNase cleavage assay and their phenotype in Japanese patients with Charcot-Marie-Tooth disease. Hum Mutat 16: 177-178, 2000


  10. Hishikawa N, Hashizume Y, Hirayama M, Imamura K, Washimi Y, Koike Y, Mabuchi C, Yoshida M, Sobue G: Brainstem-type Lewy body disease presenting with progressive autonomic failure and lethargy. Clin Auton Res 10: 139-143, 2000


  11. Misu K, Hattori N, Ando Y, Ikeda S, Sobue G: Anticipation in early-but not late onset familial amyloid polyneurolathy (TTR Met 30) in Japan. Neurology 55: 451-452, 2000


  12. Terao S, Miura N, Osano Y, Takatsu S, Mitsuma T, Sobue G: Cerebellar infarction in the territory of the medial branch of the posterior inferior cerebellar artery. J Aichi Med Univ Assoc 28: 83-88, 2000


  13. Terao S, Miura N, Takeda A, Takahashi A, Miura T, Sobue G: Course and distribution of facial corticobulbar tract fibres in the lower brain stem. J Neurol Neurosurg Psychiat 69: 262-265, 2000


  14. Inukai A, Doyu M, Kato T, Liang Y, Kuru S, Yamamoto M, Kobayashi Y, Sobue G: Reduced expression of DMAHP/SIX5 gene in myotonic dystrophy msucle. Muscle Nerve 23: 1421-1426, 2000


  15. Terao S, Osano Y, Fukuona T, Miura N, Mitsuma T, Sobue G: Coexisting vertical and horizontal one and a half syndrome. J Neurol Neurosurg Psychiat 69: 401-402, 2000


  16. Koike H, Misu K, Yasui K, Kameyama T, Ando T, Yanagi T, Sobue G: Differential response to corticosteroid therapy of MRI findings and clinical manifestations in spinal cord sarcoidosis. J Neurol 247: 544-549, 2000


  17. Kato T, Tanaka F, Yoshida E, Indo T, Watanabe H, Yoshihara T, Doyu M, Sobue G: Sisters homozygous for the spinocerebellar associated with different clinical phenotype. Clin Genet 58: 69-73, 2000


  18. Liang Y, Inukai A, Kuru S, Kato T, Doyu M, Sobue G: The role of lymphotoxin in pathogenesis of polymyositis. Acta Neuropathol 100: 521-527, 2000


  19. Sawada K, Doyu M, Tanaka F, Sobue G, Kato K: Detection of triplet repeat expansion in the human genome by use of hybridization signal intensity. Anal Biochem 286: 59-66, 2000


  20. Ito Y, Yamamoto M, Li M, Mitsuma N, Tanaka F, Doyu M., Suzumura A, Mitsuma T, Sobue G: Temporal expression of mRNAs for neuropoietic cytokine, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Rα and OSMRb) in peripheral nerve injury. Neurochem Res 25: 1113-1118, 2000


  21. Watanabe H, Tanaka F, Doyu M, Riku S, Yoshida M, Hashizume Y, Sobue G: Differential somatic CAG repeat instability in variable brain cell lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured microdissection (LCM)-based analysis. Hum Genet 107: 452-457, 2000


  22. Ishigaki S, Niwa J, Yoshihara T, Mitsuma N, Doyu M, Sobue G: Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Biochem Biophys Res Commun 279: 526-533, 2000


  23. McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, Fischbeck KH: CREB-binding protein sequestration by expanded polyglutamine. Hum Mol Genet 9: 2197-2202, 2000


  24. Misu K, Yoshihara T, Shikama Y, Awaki E, Yamamoto M, Hattori N, Hirayama M, Takegami T, Nakashima K, Sobue G: An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the periheral myelin protein zero gene (Thr124Met or Asp75Val). J Neurol Neurosurg Psychiat 69: 806-811, 2000


  25. Ito Y, Yamamoto M, Mitsuma N, Li M, Hattori N, Sobue G: Expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFRα, LIFRβ, IL-6Rα, and gp130) in human peripheral neuropathies. Neurochem Res 26: 51-58, 2001


  26. Takeda A, Wakai M, Niwa H, Dei R, Yamamoto M, Li M, Goto Y, Yasuda T, Nakagomi Y, Watanabe M, Inagaki T, Yasuda Y, Miyata T, Sobue G: Neuronal and glial advanced glycation end product Nε-(carboxymethl)lysinen Alzheimerfs disease brains. Acta Neuropathol 101: 27-35, 2001


  27. Doyu M, Sawada K, Mitsuma N, Niwa J, Yoshimoto M, Fujii Y, Sobue G, Kato K: Gene expression profile in Alzheimerfs brain screened by molecular indexing. Mol Brain Res 87: 1-11, 2001


  28. Qiao S, Iwashita T, Furukawa T, Yamamoto M, Sobue G, Takahashi M: Differential effects of LAR on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant protein. J Biol Chem 276: 9460-9467, 2001


  29. Hattori N, Misu K, Koike H, Ichimura M, Nagamatsu M, Hirayama M, Sobue G: Age of onset influences clinical features of chronic inflammatory demyelinating polyneuropathy. J Neurol Sci 184: 57-63, 2001


  30. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G: A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun 281: 706-713, 2001


  31. Yoshihara T, Kanda F, Yamamoto M, Ishihara H, Misu K, Hattori N, Chihara K, Sobue G: A novel missense mutation in the early growth response 2 gene associated with late-onset Charcot-Marie-Tooth disease type 1. J Neurol Sci 184: 149-153, 2001


  32. Ochi K, Nozaki H, Tanaka F, Kato S, Fukuzawa R, Sobue G, Fukuchi Y, Toyama Y, Hata J, Umezawa A: Specific bisulfite modification of CTG triplet repeats of the androgen receptor gene, a gene associated with the triplet repeat disease. X-linked spinal and bulbar muscular atrophy (Kennedy disease). Neurosci Res Commun 28: 1-10, 2001


  33. Adachi H, Kume A, Li M, Nakagami Y, Niwa H, Do J, Sang C, Kobayashi Y, Doyu M, Sobue G: Transgenic mice with an expande CAG repeat controlled by the human AR promoter show polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death. Hum Mol Genet 10: 1039-1048, 2001


  34. Watanabe H, Ieda T, Katayama T, Takeda A, Aiba I, Doyu M, Hirayama M, Sobue G: Cardiac I-meta-iodobenzylguanidine (MIBG) uptaken in dementia with Lewy bodies: comparison with Alzheimerfs disease. J Neurol Neurosurg Psychiat 70: 781-783, 2001


  35. Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G: Pathology-related differential expression regulation of NGF, GDNF, CNTF, and IL-6 mRNAs in human vascultic neuropathy. Muscle Nerve 24: 830-833, 2001


  36. Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G: Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology 56: 1727-1732, 2001


  37. Koike H, Misu K, Hattori N, Ito S, Ichimura M, Ito H, Hirayama M, Nagamatsu M, Sasaki I, Sobue G: Postgastrectomy polyneuropathy with thiamine deficiency. J Neurol Neurosurg Psychiat 71: 357-362, 2001


  38. Yamamoto M, Li M, Mitsuma N, Ito S, Kato M, Takahashi M, Sobue G: Preserved phosphorylation of RET receptor protein in spinal motor neurons of patients with amyotrophic lateral sclerosis: an immunohistochemical study by a phosphorylation-specific antibody at tyrosine 1062. Brain Res 912: 89-94, 2001


  39. Mori K, Koike H, Misu K, Hattori N, Ichimura M, Sobue G: Spinal cord magnetic resonance imaging demonstrates sensory neuronal involvement and clinical severity in neuronopathy associated with Sjögrenfs syndrome. J Neurol Neurosurg Psychiat 71: 488-492, 2001


  40. Watanabe H, Misu K, Hirayama M, Hattori N, Yoshihara T, Doyu M, Sobue G: Low cardiac 123I-MIBG uptake in lateonset familial amyloid polyneuropathy type I (TTR Met 30). J Neurol 248: 627-629, 2001


  41. Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I: A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimerfs disease genes and Aβ. Proc Natl Acad Sci USA 98: 6336-6341, 2001


  42. Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Widespread occurrence of argyrophilic glial inclusions in Parkinsonfs disease. Neuropathol Appl Neurobiol 27: 362-337, 2001


  43. Yoshihara T, Ishigaki S, Yamamoto M, Liang Y, Niwa J, Takeuchi H, Doyu M, Sobue G: Differential expression of inflammation-and apoptosis-related genes in spinal cords of a mutant SOD1 trangenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 80: 158-167, 2002


  44. Yamamoto M, Kobayashi Y, Li M, Niwa H, Mitsuma N, Ito Y, Mutamatsu T, Sobue G: In Vivo gene electroporation of glial cell line-derived neurotrophic factor (GDNF) into skeletal muscle of SOD1 mutant mice. Neurochem Res 26: 1201-1207, 2002


  45. Watanabe H, Misu K, Kobayashi T, Hattori N, Doyu M, Yokoyama I, Ando Y, Nakao A, Sobue G: ABO-incompatible auxiliary partial orthotopic liver transplant for late-onset familial amyloid polyneuropathy. J Neurol Sci 195: 63-66, 2002


  46. Katsuno M, Ando T, Hakusui S, Yanagi T, Sobue G: Motor conduction studies in miller fisher syndrome with severe tetraparesis. Muscle Nerve 25: 378-382, 2002


  47. Yamamoto M, Ito Y, Mitsuma N, Li M, Hattori N, Sobue G: Parallel expression of neurotrophic factors and their receptors in chronic inflammatory demyelinating polyneuropathy. Muscle Nerve 25: 601-604, 2002


  48. Mori K, Hattori N, Sygiura M, Koike H, Misu K, Ichimura M, Hirayama M, Sobue G: Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS. Neurology 58: 979-982, 2002


  49. Ikeda S, Nakazato M, Ando Y, Sobue G: Familial transthyretin-type amyloid polyneuropathy in Japan. Neurology 58: 1001-1007, 2002


  50. Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba K, Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G: Progression and prognosis in multiple system atrophy. An analysis of 230 Japanese patients. Brain 125: 1070-1083, 2002


  51. Kato M, Takeda K, Kawamoto Y, Iwashita Akhand AA, Senga T, Yamamoto M, Sobue G, Hamaguchi M, Takahashi M, Nakashima I: Repair by src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Cancer Res 62: 2414-2422, 2002


  52. Iwai K, Yamamoto M, Yoshihara T, Sobue G: Anticipation in familial amyotrophic lateral sclerosis with SOD1-G93S mutation. J Neurol Neurosurg Psychiat 72: 819-820, 2002


  53. Dei R, Takeda A, Niwa H, Li M, Nakagomi Y, Watanabe M, Inagaki T, Washimi Y, Yasuda Y, Horie K, Toshio M, Sobue G: Lipid peroxidation and advanced glycation and products in the brain in normal aging and in Alzheimerfs disease. Acta Neuropathol 104: 113-122, 2002


  54. Hattori N, Mori K, Misu K, Koike H, Ichimura M, Sobue G: Mortality and morbidity in peripheral neuropathy associated Churg-Strauss syndrome and microscopic polyangiitis. J Rheumatol 29: 1408-1414, 2002


  55. Ishigaki S, Liang Y, Yamamoto M, Niwa J., Ando Y, Yoshihara T, Takeuchi H., Doyu M, Sobue G: X-linked inhibitor of apoptosis protein is involved in mutant SOD-1 mediated neuronal degeneration. J Neurochem 82: 576-584, 2002


  56. Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G: Teststerone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 35: 843-854, 2002


  57. Niwa H, Hayakawa K, Yamamoto M, Itoh T, Mitsuma T, Sobue G: Differential age-dependent trophic responses of nodose, sensory, and sympathetic neurons to neurotrophins and GDNF: potencies for neurite extension in explant culture. Neurochem Res 27: 485-496, 2002


  58. Kato T, Indo T, Yoshida E, Iwasaki Y, Sone M, Sobue G: Contrast-enhanced 2D cine phase MR angiography for measurement of basilar artery blood flow in posterior circulation ischemia. Am J Neuroradiol 23: 1346-1351, 2002


  59. Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, Sobue G: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem 277: 36793-36798, 2002


  60. Takeuchi H, Kobayashi Y, Yoshihara T, Niwa J, Doyu M, Ohtsuka K, Sobue G: Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1. Brain Res 949: 11-22, 2002


  61. Takeuchi H, Kobayashi Y, Ishigaki S, Doyu M, Sobue G: Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-depenent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem 277: 50966-50972, 2002


  62. Sang C, Kobayashi Y, Du J, Katsuno M, Adachi H, Doyu M, Sobue G: c-Jun N-terminal kinase pathway mediates lactacustin-induced cell death in a neuronal differentiated neuro2a cell line. Mol Brain Res 108: 7-17, 2002


  63. Ishigaki S, Niwa J, Ando Y, Yoshihara T, Sawada K, Doyu M, Yamamoto M, Kato K, Yotsumoto Y, Sobue G: Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords -screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett 531: 354-358, 2002


  64. Koike H, Misu K, Ikeda S, Ando Y, Nakazato M, Ando E, Yamamoto M, Hattori N, Sobue G: Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Arch Neurol 59: 1771-1776, 2002


  65. Ito Y, Kato T, Suzuki T, Yokokawa Y, Aiba I, Arahata Y, Ito E, Ito K, Yasuda T, Sobue G: Neuroradiologic and clinical abnormalities in dementia of diffuse neurofibrillary tangles with calcification (Kosaka-Shibayama disease). J Neurol Sci 209: 105-109, 2002


  66. Kuru S, Inukai A, Kato T, Liang Y, Kimura S, Sobue G: Expression of tumor factor-α in regenerating muscle fibers in inflammatory and non-inflammatory myopathies. Acta Neuropathol 105: 217-224, 2003


  67. Kobayashi R, Koike Y, Hirayama M, Ito H, Sobue G: Skin sympathetic nerve function sleep-a study with effector responses. Anton Neurosci 103: 121-126, 2003


  68. Hattori N, Yamamoto M, Yoshihara T, Koike H, Nakagawa N, Yoshikawa H, Ohnishi A, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakashima K, Kira J, Kaji R, Oka N, Sobue G, the Study Group for Hereditary Neuropathy in Japan: Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients. Brain 126: 134-151, 2003


  69. Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Clinical and neuropathological correlates of Lewy body disease.  Acta Neuropathol 105: 341-350, 2003


  70. Yamada T, Nakamura A, Horibe K, Washimi Y, Bundo M, Kato T, Ito K, Kachi T, Sobue G: Asymmetrical enhancement of middle-latency auditory evoked fields with aging. Neurosci Lett 337: 21-24, 2003


  71. Hamada K, Hirayama M, Watanabe H, Kobayashi R, Ito H, Ieda T, Koike Y, Sobue G: Onset age and severity impairment are associated with reduction of myocardial 123I-MIBG uptake in Parkinsonfs disease. J Neurol Neurosurg Psychiat 74: 423-426, 2003


  72. Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatous G, Angelidis C, Kusakabe M, Yoshiki A, Kobayashi Y, Doyu M, Sobue G: Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein. J Neurosci 23: 2203-2211, 2003


  73. Hirayama M, Fukatsu H, Watanabe H, Koike Y, Noda A, Ito H, Kobayashi R, Sobue G: Sequential constriction of upper airway and vocal cords in sleep apnoea of multiple system atrophy: low field magnetic resonance fluoroscopic study. J Neurol Neurosurg Psychiat 74: 642-645, 2003


  74. Abe Y, Kachi T, Arahata Y, Yamada T, Washimi Y, Iwai K, Ito K, Yanagisawa N, Sobue G: Occipital hypoperfusion in Parkinsonfs disease without dementia: correlation to impaired cortical visual processing. J Neurol Neurosurg Psychiat 74: 419-422, 2003


  75. Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G: Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol 54: 19-29, 2003


  76. Hishikawa N, Hashizume Y, Yoshida M, Sobue G: Reply to K. Jellinger. Acta Neuropathol 106: 109, 2003


  77. Katsuno M, Adachi H, Doyu M, Minamiyama M, Sang C, Kobayashi Y, Inukai A, Sobue G: Leuprorelin rescue polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy. Nat Med 9: 768-773, 2003


  78. Hishikawa N, Niwa J, Doyu M, Ito T, Ishigaki S, Hashizume Y, Sobue G: Dorfin localizes to the ubiquitilated inclusions in Parkinsonfs disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am J Pathol 163: 609-619, 2003


  79. Hishikawa N, Hashizume Y, Ujihara N, Okada Y, Yoshida M, Sobue G: α-Synuclein-positive structures in associations with diffuse neurofibrillary tangles with calcification. Neuropathol Appl Neurobiol 29: 280-287, 2003


  80. Ishihara K, Yamagishi N, Saito Y, Adachi H, Kobayashi Y, Sobue G, Ohtsuka K, Hatayama T: Hsp 105α suppresses the aggregation of truncated androgen receptor with expanded CAG repeats and cell toxicity. J Biol Chem 278: 25143-25150, 2003


  81. Ito T, Niwa J, Hishikawa N, Ishigaki S, Doyu M, Sobue G: Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem 278: 29106-29114, 2003


  82. Mori K, Iijima M, Sugiura M, Koike H, Hattori N, Ito H, Hirayama M, Sobue G: Sjögrenfs syndrome associated painful sensory neuropathy without sensory ataxia. J Neurol Neurosurg Psychiat 74: 1320-1322, 2003


  83. Ando Y, Liang Y, Ishigaki S, Niwa J, Jiang Y, Kobayashi Y, Yamamoto M, Doyu M, Sobue G: Caspase-1 and -3 are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study usign laser microdissection and real time RT-PCR. Neurochem Res 28: 839-846, 2003


  84. Katsuno M, Adachi H, Inukai A, Sobue G: Transgenic mouse models of spinal and bulbar muscular atrophy (SBMA). Cytogenet Genome Res 100: 243-251, 2003


  85. Sobue G, Koike H, Misu K, Hattori N, Yamamoto M, Ikeda S, Ando Y, Nakazato M, Inukai A: Clinicopathologic and genetic features of early- and late-onset FAP type I (FAP ATTR Val30Met) in Japan. Amyloid 1: 32-38, 2003


  86. Nodera H, Bostock H, Kuwabara S, Sakamoto T, Asanuma K, Jia-Ying S, Ogawara K, Hattori N, Hirayama M, Sobue G, Kaji R: Nerve excitability properties in Charcot-Marie-Tooth disease type 1A. Brain 127: 203-211, 2003


  87. Wada M, Kimura M, Daimon M, Kurita K, Kato T, Johmura Y, Johkura K, Kuroiwa Y, Sobue G: An unusual phenotype of Mcleod syndrome with late onset axonal neuropathy. J Neurol Neurosurg Psychiat 74: 1697-1699, 2003


  88. Watanabe H, Fukatsu H, Katsuno M, Sugiura M, Hamada K, Okada Y, Hirayama M, Ishigkai T, Sobue G: Multiple regional 1H-MR spectroscopy in multiple system atrophy: NAA/Cr reduction in pontine base as a valuable diagnostic marker. J Neurol Neurosurg Psychiat 75: 103-109, 2004


  89. Watanabe H, Fukatsu H, Hisikawa N, Hashizume Y, Sobue G: Field strengths and sequences influence putaminal MRI findings in multiple system atrophy. Neurology 62: 671, 2004


  90. Yamamoto M, Yoshihara T, Hattori N, Sobue G: Glu528del in NEFL is a polymorphic variant rather than a disease-causing mutant for Charcot-Marie-Tooth disease in Japan. Neurogenetics 5: 75-77, 2004


  91. Konagaya M, Matsumoto A, Takase S, Mizutani T, Sobue G, Konishi T, Hayabara T, Iwashita H, Ujihira T, Miyata T, Matsuoka Y: Clinical analysis of longstanding substance myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban. J Neurol Sci 218: 85-90, 2004


  92. Takeuchi H, Niwa J, Hishikawa N, Ishigaki S, Tanaka F, Doyu M, Sobue G: Dorfin prevents cell death by reducing mitochondrial localiaing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. J Neurochem 89: 64-72, 2004


  93. Yamada S, Matsuo K, Hirayama M, Sobue G: The effects of levodopa on apraxia of lid opening: A case report. Neurology 62: 830-831, 2004


  94. Terao S, Miura N, Osano Y, Noda A, Sobue G: Rapidly progressive fatal respiratory failure (Ondinefs curse) in the lateral medullary sundrome. J Stroke Cerebrovasc Dis 13: 41-44, 2004


  95. Minamiyama M, Katsuno M, Adachi H, Waza M, Sang C, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Sobue G: Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Hum Mol Genet 13: 1183-1192, 2004


  96. Ohmori H, Ando Y, Makita Y, Onouchi Y, Nakajima T, Saraiva MJM, Terazaki H, Suhr O, Sobue G, Nakamura M, Yamaizumi M, Munar-Ques M, Inoue I, Uchino M, Hata A: Common origin of the Val30Met mutatioin responsible for the amyloidogenic transthyretin type of familial amyloidotic polyneuropathy. J Med Genet 41: 1-5, 2004


  97. Koike H, Misu K, Sugiura M, Iijima M, Mori K, Yamamoto M, Hattori N, Mukai E, Ando Y, Ikeda S, Sobue G: Pathology of early- vs late-onset TTR Met30 familial amyloid polyneuropathy. Neurology 63: 129-138, 2004


  98. Kurihara S, Adachi Y, Imai C, Araki H, Hattori N, Numakura C, Lin Y, Hayasaka K, Sobue G, Nakashima K: Charcot-Marie-Tooth families in Japan with MPZ Thr124Met mutation. J Neurol Neurosurg Psychiat 75: 1492-1494, 2004


  99. Mitsuma N, Yamamoto M, Iijima M, Hattori N, Ito Y, Tanaka F, Sobue G: Wide range of lineages of cells expressing nerve growth factor mRNA in the nerve lesions of patients with vasculitic neuropathy: An implication of endoneurial macrophage for nerve regeneration. Neuroscience 129: 109-117, 2004


  100. Mabuchi N, Watanabe H, Atsuta N, Hirayama M, Ito H, Fukatsu H, Kato T, Ito K, Sobue G: Primary lateral sclerosis presenting parkinsonian symptoms without nigrostriatal involvement. J Neurol Neurosurg Psychiat 75: 1768-1771, 2004


  101. Ishigaki S, Hishikawa N, Niwa J, Iemura S, Natsume T, Hori S, Kakizuka A, Tanaka K, Sobue G: Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem 279: 51376-51385, 2004


  102. Koike H, Iijima M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G: Postgastrectomy polyneuropathy with thiamine deficiency is identical to beriberi neuropathy. Nutrition 20: 961-966, 2004


  103. Okada Y, Shimazaki T, Sobue G, Okano H: Retinoic-acid-concentration-dependent acquisition of neural cell identity during in vitro differentiation of mouse embryonic stem cells. Dev Biol 275: 124-142, 2004


  104. Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, Takeuchi H, Ishigaki S, Katsuno M, Adachi H, Niwa J, Tanaka F, Doyu M, Yoshida M, Hashizume Y, Sobue G: Gene expression profile of motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol 57: 236-251, 2005


  105. Adachi H, Katsuno M, Minamiyama M, Waza M, Sang C, Nakagomi Y, Kobayashi Y, Tanaka F, Doyu M, Inukai A, Yoshida M, Hashizume Y, Sobue G: Widespread nuclear and cytoplasmic mutant androgen receptor accumulation in spinal and bulbar muscular atrophy. Brain 128: 659-670, 2005


  106. Iijima M, Yamamoto M, Hirayama M, Tanaka F, Katsuno M, Mori K, Koike H, Hattori N, Arimura K, Nakagawa M, Yoshikawa H, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakazato M, Nakashima K, Kira J, Kaji R, Oka N, Sobue G: Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP. Neurology 64: 1471-1475, 2005


@M@(VwEwE]_o)
  1. Lu CS, Wu JC, Tsai CH, Chen RS, Chou WYH, Hattori N, Yoshino H, Mizuno, Y: Clinical and genetic studies on familial parkinsonism: The first report on a parkin gene mutation in a Taiwanese family. Mov Disord 16: 164-166, 2001


  2. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R: An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin. Cell 105: 891-902, 2001


  3. Jeon BS, Kim JM, Lee DS, Hattori N, Mizuno Y: An apparently sporadic case with parkin gene mutation in a Korean woman. Arch Neurol 58: 988-989, 2001


  4. Nisipeanu P, Inzelberg R, Abo Mouch S, Carasso RL, Blumen SC, Zhang J, Matsumine H, Hattori N, Mizuno Y: Parkin gene causing benign autosomal recessive juvenile parkinsonism. Neurology 56: 1573-1577, 2001


  5. Mellick GD, Buchanan DD, Hattori N, Brookes AJ, Mizuno Y, Le Couteur DG, Silburn PA: The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls. Parkinsonism Relat Disord 7: 89-91, 2001


  6. Mogi M, Togari A, Kondo T, Mizuno Y, Kogure O, Kuno S, Ichinose H, Nagatsu T: Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains. Neurosci Lett 300: 179-181, 2001


  7. Kubo S, Kitami T, Noda S, Shimura H, Uchiyama Y, Asakawa S, Minoshima S, Shimizu N, Mizuno Y, Hattori N: Parkin is associated with cellular vesicles. J Neurochem 78: 42-54, 2001


  8. Miwa H, Kagohashi M, Noda K, Miyashita N, Tanaka S, Mizuno Y: Eyelid motor extinction. J Neurol 248: 343-344, 2001


  9. Miwa H, Fuwa T, Nishi K, Kondo T: Subthalamo-pallido-striatal axis: a feedback system in the basal ganglia. NeuroReport 12: 3795-3798, 2001


  10. Miwa H, Mizuno Y: Capgras syndrome in Parkinson's disease. J Neurol 248: 804-805, 2001


  11. Miwa H, Furuya T, Tanaka S, Mizuno Y: Neurosarcoidosis associated with interferon therapy. Eur Neurol 45: 288-289, 2001


  12. Miwa H, Miwa T, Imai H, Mizuno Y: Obsessive compulsive disorder-like behavioral changes in pure akinesia. Parkinsonism Relat Disord 7: 315-317, 2001


  13. Miwa H, Iijima M, Tanaka S, Mizuno Y: Generalized convulsions after consuming a large amount of Gingko nuts. Epilepsia 42: 280-281, 2001


  14. Noda K, Okuma Y, Fukae J, Fujishima K, Sadamasa H, Yoshiike T, Mizuno Y: Sweetfs syndrome associated with encephalitis. J Neurol Sci 188: 95-97, 2001


  15. Noda K, Miwa H, Miyashita N, Tanaka S, Mizuno Y: Monoataxia of upper extremity in motor cortical infarction. Neurology 56: 1418-1419, 2001


  16. Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y: An AAV-derived apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinsonfs disease. Proc Natl Acad Sci USA 98: 10918-10923, 2001


  17. Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309: 89-92, 2001


  18. Nohara C, Akiba H, Nakajima A, Inoue A, Koh CS, Ohshima H, Yagita H, Mizuno Y, Okumura Y: Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand monoclonal antibody: A critical role for OX40 ligand in migration, but not development, of pathogenic T cells. J Immunol 166: 2108-2115, 2001


  19. Okuma Y, Tanaka R, Fujishima K, Kobayashi T, Mizuno Y: Cortical reflex action myoclonus in neurosyphilis. Eur Neurol 45: 193-194, 2001


  20. Okuma Y, Mizuno Y: Myoclonic tremor in patients with parkinsonian-type multiple system atrophy. Mov Disord 16: 378-379, 2001


  21. Okuma Y, Fujishima K, Machida Y, Inagaki N, Sugita Y, Mizuno Y: Propriospinal negative myoclonus. Eur Neurol 46: 99-101, 2001


  22. Shimo-Nakanishi Y, Urabe T, Hattori N, Watanabe Y, Nagao T, Yokochi M, Hamamoto M, Mizuno Y: Polymorphism of the lipoprotein lipase gene and risk of atherothrombotic cerebral infarction in the Japanese. Stroke 32: 1481-1486, 2001


  23. Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ: Ubiquitination of a new form of α-synuclein by parkin from human brain: Implications for Parkinson's disease. Science 293: 263-269, 2001


  24. Takanashi M, Mochizuki H, Yokomizo K, Hattori N, Mori H, Yamamura Y, Mizuno Y: Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP). Parkinsonism Relat Disord 7: 311-314, 2001


  25. Tanaka K, Suzuki T, Chiba T, Shimura H, Hattori N, Mizuno Y: Parkin is linked to the ubiquitin pathway. J Mol Med 79: 482-494, 2001


  26. Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka K, Mizuno Y, Hattori N: Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain. J Neurochem 77: 1561-1568, 2001


  27. Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner P: Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome. J Biol Chem 277: 28572-28577, 2002


  28. Kobayashi T, Mori H, Okuma Y, Dickson DW, Cookson N, Tsuboi Y, Motoi Y, Tanaka R, Miyashita N, Anno M, Narabayashi H, Mizuno Y: Constrasting genotypes of the tau gene in two phenotypically distinct patients with P301L mutation of frontotemporal dementia and parkinsonism linked to chromosome 17. J Neurol 249: 669-675, 2002


  29. Miwa H, Kajimoto M, Kondo T: Chorea in motor neuron disease. Move Disord (letter) 17: 1397, 2002


  30. Miwa H, Kondo T, Mizuno Y: Bell's palsy-induced blepharospasm. J Neurol 249: 452-454, 2002


  31. Miwa H, Mizuno Y: Enlargements of somatosensory-evoked potentials in progressive supranuclear palssy. Acta Neurol Scand 106: 209-212, 2002


  32. Miwa H, Mizuno Y, Kondo T: Familial hemifacial spasm: report of cases and review of literature. J Neurol Sci 193: 97-102, 2002


  33. Mori H, Oda M, Komori T, Arai N, Takanashi M, Mizutani T, Hirai S, Mizuno Y: Lewy bodies in progressive supranuclear palsy. Acta Neuropathol 104: 273-278, 2002


  34. Ohizumi H, Okuma Y, Fukae J, Fujishima K, Goto K, Mizuno Y: Head tremor in dentatorubral-pallidoluysian atrophy. Acta Neurol Scand 106: 319-321, 2002


  35. Okuma Y, Mizuno Y, Lee RG: Reciprocal Ia inhibition in patients with asymmetric spinal spasticity. Clin Neurophysiol 113: 292-297, 2002


  36. Schossmacher MG, Frosch MP, Ping-Gai W, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik K: Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 160: 1655-1667, 2002


  37. Suzuki A, Obi K, Urabe T, Hayakawa H, Yamada M, Kaneko S, Onodera M, Mizuno Y, Mochizuki H: Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral vector GCDNsap packaged in the vesicular stomatitis virus G protein. J Neurochem 82: 953-960, 2002


  38. Takanashi M, Mori H, Arima K, Mizuno Y, Hattori N: Expression pattern of tau mRNA isoforms correlates with susceptible lesions in progressive supuranuclear palsy and corticobasal degeneration. Mol Brain Res 104: 210-219, 2002


  39. Takanashi M, Ohta S, Matsuoka S, Mori H, Mizuno Y: Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case. Acta Neuropathol 103: 82-87, 2002


  40. Tanaka M, Fuku N, Takeyasu T, Guo L-J, Hirose R, Kurata M, Borgeld HJ, Yamada Y, Maruyama W, Arai Y, Hirose N, Oshida Y, Sato Y, Hattori N, Mizuno Y, Iwata S, Yagi K: Golden mean to longevity: Rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinsonfs disease. J Neurosci Res 70: 347-355, 2002


  41. Tanaka R, Mochizuki H, Suzuki A, Ishitani R, Katsube N, Mizuno Y, Urabe T: Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in rat brain after focal ischemia/reperfusion. J Cereb Blood Flow Metab 22: 280-288, 2002


  42. Tsuboi Y, Baker M, Hutton ML, Uitti RJ, Rascol O, Delisle MB, Soulages X, Murrell JR, Ghetti B, Yasuda M., Komure O. Kuno S, Arima K, Sunohara N, Kobayashi T, Mizuno Y, Wszolek ZK: Clinical and genetic studies of families with the tau N279K mutation (FTDP-17). Neurology 59: 1791−1793, 2002


  43. Urabe T, Tanaka R, Noda K, Mizuno Y: Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy. J Thromb Thrombolysis 13: 153-158, 2002


  44. Furuya T, Tanaka R, Urabe T, Hayakawa J, Yamada M, MigitaM, Shimada T, MizunoY, Mochizuki H: Establishment of modified chimeric mice using GFP bone marrow as a model for neurological disorders NeuroReport 14: 629-631, 2003


  45. Gouider-Khouja m, Larnaout A, Amouri R, Sfar S, Belal S, Hamida CB, Hamida MB, Hattori N, Mizuno Y, Hentati F: Autosomal recessive parkinsonism linked to parkin gene in Tunisian family. Clinical, genetic and pathological study. Parkinsonism Relat Disord 9: 247-251, 2003


  46. Hatano T, Okuna Y, Iijima M, Fujishima K, Goto K, Mizuno Y: Cervical dystonia in dentatorubral-pallidoluysian atrophy. Acta Neurol Scand 108: 287-289, 2003


  47. Inzelberg R, Hattori N, Nisipeanu P, Abo Mouch S, Blumen SC, Carasso RL, Mizuno Y: Camptocormia, axial dystonia, and parkinsonism: Phenotypic heterogeneity of a parkin mutation. Neurology 60: 1393-1394, 2003


  48. Kim SJ, Sung JY, Um JW, Hattori N, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung KC: Parkin cleaves intracellular alpha-synuclein inclusions via the activation of calpain. J Biol Chem 278: 41890-41899, 2003


  49. Kobayashi H, Kruger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki, Murayama K, Riess O, Mizuno Y, Hattori N: Haploinsufficiency at the α-synuclein gene underlies phenotypic severity in familial Parkinson's disease. Brain 126: 32-42, 2003


  50. Kobayashi T, Matsumine H, Zhang J, Imamichi Y, Mizuno Y, Hattori N: Pseudo-autosomal dominant inheritance of PARK2: two families with parkin gene mutations. J Neurol Sci 207: 11-17, 2003


  51. Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology. Ann Neurol 53: 133-137, 2003


  52. Nagano Y, Yamashita H, Takahashi T, Kishida S, Nakamura T, Iseki E, Hattori N, Mizuno Y, Kikuchi A, Matsumoto M: Siah-1 facilitates ubiquitination and degradation of synphilin-1. J Biol Chem 278: 51504-51514, 2003


  53. Mizuno Y, Yanagisawa N, Kuno S, Yamamoto M, Hasegawa K, Origasa H, Kowa H, The Japan Pramipexole Study Group: Randomized, double-blind study of pramipexole with placebo and bromocriptine in advanced Parkinson's disease. Mov Disord 18: 1149-1156, 2003


  54. Rawal N, Periquet M, Lohmann E, Lucking CB, Teive HA, Ambrosio G, Raskin S, Lincoln S, Hattori N, Guimaraes J, Horstink MW, Dos Santos Bele W, Brousolle E, Destee A, Mizuno Y, Farrer M, Deleuze JF, De Michele G, Agid Y, Durr A, Brice A, French Parkinson's Disease Genetics Study Group: European Consortium on Genetic Susceptibility in Parkinson's Disease. New parkin mutations and atypical phenotypes in families with autosomal recessive parkinsonism. Neurology 60: 1378-1381, 2003


  55. Sakata E, Yamaguchi Y, Kurimoto E, Yokoyama S, Yamada S, Kawahara H, Yokosawa H, Hattori N, Mizuno Y, Tanaka K: Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain. EMBO Rep 4: 301-306, 2003


  56. Shimo-Nakanishi Y, Hasebe T, Suzuki A, Mochizuki H, Nomiyama T, Tanaka Y, Nagaoka I, Mizuno Y, Urabe T: Functional effects of NAD(P)H oxidase p22(phox) C242T mutation in human leukocytes and association with thrombotic cerebral infarction. Atherosclerosis 175: 109-115, 2004


  57. Takahashi R, Imai Y, Hattori N, Mizuno Y: Parkin and endoplasmic reticulum stress. Ann NY Acad Sci 911: 101-106, 2003


  58. Takubo H, Harada T, Hashimoto T, Inaba Y, Kanazawa I, Kuno S, Mizuno Y, Mizuta E, Murata M, Nagatsu T, Nakamura S, Yanagisawa N, Narabayashi H: A collaborative study on the malignant syndrome in Parkinson's disease and related disorders. Parkinsonism Relat Didord 9 (Suppl 1): S31-S41, 2003


  59. Takubo H, Shimoda SM, Mizuno Y: Serum creatine kinase is elevated in patients with Parkinson's disease: a case controlled study. Parkinsonism Relat Didord 9 (Suppl 1): S43-S46, 2003


  60. Tanaka R, Komine KM, Mochizuki M, Yamada M, Furuya T, Migita M, Shimada T, Mizuno Y, Urabe T: Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia. Neuroscience 117: 531-539, 2003


  61. Tanaka R, Yamashiro K, Mochizuki H, Cho N, Onodera M, Mizuno Y, Urabe T: Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector. Stroke 35: 1454-1459, 2004


  62. Toda T, Momose Y, Murata M, Tamiya G, Yamamoto M, Hattori N, Inoko H: Toward identification of susceptibility genes for sporadic parkinson's disease. J Neurol 205[suppl3]: III40-III43, 2003


  63. Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H: Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1α, and expression of caspase-11 in mice. J Biol Chem 279: 51647-51653, 2004


  64. Furuya T, Hayakawa H, Yamada M, Yoshimi K, Hisahara S, Miura M, Mizuno Y, Mochizuki H: Caspase-11 mediates inflammatory dopaminergic cell death in the 1-methyl-4-phenyl-1, 2, 3, 6 -tetrahydropyridine mouse model of Parkinsonfs disease. J Neurosci 24: 1865-1872, 2004


  65. Hatano Y, Li Y, Sato K, Asakwa S, Yamamura Y, Tomiyama H, Yoshino H, Asahina M, Kobayshi S, Ng Ar Rosales RL, Hassin-Bear S, Shinar Y, Lu CS, Shimizu N, Toda T, Mizuno Y, Hattori N: Novel PINK1 mutations in early-onset parkinsonism. Ann Neurol 56: 424-427, 2004


  66. Hatano Y, Sato K, Elibol B, Yoshino H, Yamamura Y, Bonifati V, Shinotoh H, Asahina M, Kobayshi S, Ng Ar Rosales RL, Hassin-Bear S, Shinar Y, Lu CS, Chang HC, Wu Chou, YH, Atac FB, Kobayashi T, Toda T, Mizuno Y, Hattori N: PARK6-linked autosomal recessive early-onset parkinsonism in Asian populations. Neurology 63: 1482-1485, 2004


  67. Hattori N, Mizuno Y: Pathogenetic mechanisms of parkin in Parkinsonf s disease. Lancet 364: 722-724, 2004


  68. Higashi Y, Asanuma M, Miyazaki I, Hattori N, Mizuno Y, Ogawa N: Parkin attenuates manganese-induced dopaminergic cell death. J Biol Chem 89: 1490-1497, 2004


  69. Kagohashi M, Okuma Y, Fujishima K, Kitada T, Mizuno Y: Blepharospasm associated with multiple system atrophy: A case report and review of the literature. Parkinsonism Relat Disord 10: 169-171, 2004


  70. Komine-Kobayashi M, Chou N, Mochizuki H, Nakao A, Mizuno Y, Urabe T: Dual role of Fcgamma receptor in transient focal cerebral ischemia in mice. Stroke 35: 958-963, 2004


  71. Motoi Y, Itaya M, Mori H, Mizuno Y, Iwasaki T, Hattori H, Haga S, Ikeda K: Apolipoprotein E receptor 2 is involved in neuritic plaque formation in APP sw mice. Neurosci Lett 368: 144-147, 2004


  72. Motoi Y, Takanashi M, Itaya M, Ikeda K, Mizuno Y, Mori H: Glial localization of four-repeat tau in atypical progressive supranuclear palsy. Neuropathology 24: 60-65, 2004


  73. Shimo-Nakanishi Y, Hasebe T, Suzuki A, Mochizuki H, Npmiyama T, Tanaka Y, Nagaoka I, Mizuno Y, Urabe T: Functional effects of NAD (P) H oxidase p22phox C242T mutation in human leukocytes and association with thrombotic cerebral infarction. Atherosclerosis 175: 109-115, 2004


  74. Tanaka M, Cabrera VM, Gonzalez AM, Larruga JM, Takeyasu T, Fuku N, Guo LJ, Hirose R, Fujita Y, Kurata M, Shinoda K, Umetsu K, Yamada Y, Oshida Y, Sato Y, Hattori N, Mizuno Y, Arai Y, Hirose N, Ohta S, Ogawa O, Tanaka Y, Kawamori R, Shamoto-Nagai M, Maruyama W, Shimokata H, Suzuki R, Shimodaira H: Mitochondrial genome variation in eastern Asia and the peopling of Japan. Genome Res 14: 1832-1850, 2004


  75. Tanaka R, Yamashiro K, Mochizuki H, Cho N, Onodera M, Mizuno Y, Urabe T: Neurogenesis after transient global ischemia in the adult hippocampus visualized by improved retroviral vector. Stroke 35: 1454-1459, 2004


  76. Tsuchiya K, Tajima H, Kuwae T, Takeshima T, Nakano T, Tanaka M, Sunaga K, Fukuhara Y, Nakashima K, Ohama E, Mochizuki H, Mizuno Y, Katsube N, Ishitani R: Pro-apoptotic protein glyceraldehyde-3-phosphate dehydrogenase promotes the formation of Lewy body-like inclusions. Eur J Neurosci 21: 317-326, 2004


  77. Watanabe T, Okuma Y, Fujishima K, Kitada T, Nakao Y, Mizuno Y: Isolated deep venous thrombosis: An important cause for isolated mental impairment. Eur Neurol 52: 123-125, 2004


  78. Yamada M, Iwatubo T, Mizuno Y, Mochizuki H: Overexpression of α-synuclein in rat substantia nigra results in loss of dopaminergic neurons, phosphorylation of α-synuclein and activation of caspase-9: resemblance to pathogenetic changes in Parkinsonfs disease. J Neurochem 91: 451-461, 2004


  79. Yamada M, Onodera M, Mizuno Y, Mochizuki H: Neurogenesis in olfactory bulb identified by retroviral labeling in normal and 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-treated adult mice. Neuroscience 124: 173-181, 2004


  80. Yamashiro K, Okuma Y, Fujishima K, Goto K, Mizuno Y: Bilateral hypoglossal nerve involvement in chronic inflammatory demyelonating polyneuropathy. Eur Neurol 51: 45-46, 2004


  81. Fukae J, Takanashi M, Kubo S, Nishioka K, Nakabeppu Y, Mori H, Mizuno Y, Hattori N: Expression of 8-oxoguanine DNA glycosylase (OGG1) in Parkinsonfs disease and related neurodegenerative disorders. Acta Neuropathol 109: 256-262, 2005


  82. OkumaY, Kagohashi M, Mizuno Y: (Reply to letter to the editor) Neurophysiology of blepharospasm in multiple system strophy. Parkinsonism Relat Disord 11: 203-204, 2005


  83. Okuma Y, Fujishima K, Miwa H, Mori H, Mizuno Y: Myoclonic tremulous movements in multiple system atrophy are a form of cortical myoclonus. Mov Disord 20: 451-456, 2005


  84. Noda K, Kitami T, Gai WP, Chegini F, Jensen PH, Fujimura T, Murayama K, Tanaka K, Mizuno Y, Hattori N: Phosphtorylated IκBα is a component of Lewy body of Parkinsonfs disease. Biochem Biophys Res Commun 331: 309-317, 2005


  85. Watanabe T, Okuma Y, Fujishima K, Kitada T, Nakao Y, Mizuno Y: Isolated deep venous thrombosis: An important cause for isolated mental impairment. Eur Neurol 52: 317-326, 2005


  86. Yamada M, Mizuno Y, Mochizuki H: Parkin gene therapy for α-synucleinopathy: A rat model of Parkinsonfs disease. Hum Gene Ther 16: 262-270, 2005


  87. Nishioka K, Fujishima K, Kobayashi H, Mizuno Y, Okuma Y: An extremely unusual presentation of varicella zoster viral infection of cranial nerves mimicking Garcin syndrome. Clin Neurol Neurosurg in press


rc@q@(CwEw)
  1. Matsuyama N, Hadano S, Onoe K, Osuga H, Showguchi-Miyata J, Gondo Y, Ikeda J-E: Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat. Genomics 69: 72-85, 2000


  2. Saitoh Y, Miyamoto N, Okada T, Gondo Y, Showguchi-Miyata J, Hadano S, Ikeda J-E: The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promotor. Genomics 67: 291-300, 2000


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  4. Hadano S, Hand CK, Osuga H, Yanagisawa Y, Otomo A, Devon RS, Miyamoto N, Showguchi-Miyata J, Okada Y, Singaraja R, Figlewicz DA, Kwiatkowski T, Hosler B A, Sagie T, Skaug J, Nasir J, Brown RH, Jr Scherer SW, Rouleau GA, Hayden MR, Ikeda J-E: A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat Genet29: 166-173, 2001


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  13. Otomo A, Hadano S, Okada T, Mizumura H, Kunita R, Nishijima H, Showguchi-Miyata J, Yanagisawa Y, Kohiki E, Suga E, Yasuda M, Osuga H, Nishimoto T, Narumiya S, Ikeda J-E: ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum Mol Genet 12: 1671-1687, 2003


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  15. Storbeck CJ, Drmanic S, Daniel K, Waring JD, Jirik FR, Parry DJ, Ahmed N, Sabourin LA, Ikeda J-E, Korneluk RG: Inhibition of myogenesis in transgenic mice expressing the human DMPK 3'-UTR. Mol Genet 13: 589-600, 2004


ؑ@mq@(sՏw)
  1. Kimura Y, Koitabashi S, Fujita T: Analysis of yeast prion aggregates with amyloid-staining compound in vivo. Cell Struc Func 28: 187-193, 2003


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  1. Nagai M, Aoki M, Miyoshi I, Kato M, Pasinelli P, Kasai N, Brown RH Jr, Itoyama Y: Rats expressing human cytosolic Cu/Zn superoxide dismutase transgenes with amyotrophic lateral sclerosis-associated mutations develop motor neuron disease. J Neurosci 21: 9246-9254, 2001


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  3. Saito A, Higuchi I, Nakagawa M, Saito M, Hirata K, Suehara M, Yoshida Y, Takahashi T, Aoki M, Osame M: Miyoshi myopathy patients with novel 5' splicing donor site mutations showed different immunostaining at sarcolemma. Acta Neuropathol 104: 615-620, 2002


  4. Nishino I, Noguchi S, Murayama K, Driss A, Sugie K, Oya Y, Nagata T, Chida K, Takahashi T, Takusa Y, Ohi T, Nishimiya J, Sunohara N, Ciafaloni E, Kawai M, Aoki M, Nonaka I: Distal myopathy with rimmed vacuoles is allelic to hereditary inclusion body myopathy. Neurology 59: 1689-1693, 2002


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  7. Kato S, Saeki Y, Aoki M, Nagai M, Ishigaki A, Itoyama Y, Kato M, Asayama K, Awaya A, Hirano A, Ohama E: Histological evidence of redox system breakdown caused by superoxide dismutase 1 (SOD1) aggregation is common to mutant SOD-1-linked familial amyotrophic lateral sclerosis patients and transgenic rats expressing human mutant SOD1. Acta Neuropathol 107: 149-58, 2004


  8. Miyazaki K, Fujita T, Ozaki T, Kato C, Kurose Y, Sakamoto M, Kato S, Goto T, Itoyama Y, Aoki M, Nakagawara A: NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. J Biol Chem 279: 11327-11335, 2004


  9. Chang-Hong R, Wada M, Koyama S, Kimura H, Arawaka S, Kawanami T, Kurita K, Kadoya T, Aoki M, Itoyama Y, Kato T: Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 194: 203-211, 2005


@qF@(sVlE_oHԌO[v)
  1. Tateno M, Sadakata H, Tanaka M, Itohara S, Shin R-M, Miura M, Masuda M, Aosaki T, Urushitani M, Misawa H, Takahashi R: Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum Mol Genet 13: 2183-2196, 2004


  2. Shin R-M, Masuda M, Miura M, Sano H, Shirasawa T, Song W-J, Kobayashi K, Aosaki T: Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci 23: 11662-11672, 2003


  3. Miura M, Watanabe M, Offermanns S, Simon MI, Kano M: Group I metabotropic glutamate receptor signaling via Galpha q/Galpha 11 secures the induction of long-term potentiation in the hippocampal area CA1. J Neurosci 22: 8379-8390, 2002


  4. Nakajima M, Miura M, Aosaki T, Shirasawa T: Deficiency of presenilin-1 increases calcium-dependent vulnerability of neurons to oxidative stress in vitro. J Neurochem 78: 807-814, 2001


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r@Ɏ@(R`wEw)
  1. Ren CH, Wada M, Koyama S, Kimura H, Arawaka S, Kawanami T, Kurita K, Kadoya T, Aoki M, Itoyama Y, Kato T: Neuroprotective effect of oxidized galectin-1 in a transgenic mouse model of amyotrophic lateral sclerosis. Exp Neurol 194: 203-211, 2005


L@F@(kCwEw@w)
  1. Taira T, Saito Y, Niki T, Iguchi-Ariga SM, Takahashi K, Ariga H: DJ-1 plays a role in anti-oxidative stress to prevent cell death. EMBO Rep 5: 213-218, 2004


  2. Bandopadhyay R, Kingsbury A, Cookson M, Reid A, Evans I, Hope A, Pittman A, Lashley T, Canet-Aviles R, Miller D, Mc Lendon C, Strand C, Leonard A, Ariga H, Wood N, de Silva R, Hardy J, Holton J, Lees A, Revesz T: The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinsonfs disease. Brain 127: 420-430, 2004


  3. Taira T, Iguchi-Ariga SMM, Ariga H: Co-localization with DJ-1 is essential for the androgen receptor to exert its transcription activity that has been impaired by androgen-antagonists. Biol Pharm Bull 27: 574-577, 2004


  4. Kinumi T, Kimata J, Taira T, Ariga H, Niki E: Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun 317: 722-728, 2004


  5. Takahashi-Niki K, Niki T, Taira T, Iguchi-Ariga SMM, Ariga H: Reduced anti-oxidative stress activities of DJ-1 mutants found in Parkinsonfs disease patients. Biochem Biophys Res Commun 320: 389-397, 2004


  6. Sekito A, Taira T, Niki T, Iguchi-Ariga SM, Ariga H: Stimulation of transforming activity of DJ-1 by Abstrakt, a DJ-1-binding protein. Int J Oncol 26: 685-690, 2005


  7. Shinbo Y, Taira T, Niki T, Iguchi-Ariga SM, Ariga H: DJ-1 restores p53 transcription activity inhibited by Topors/p53BP3. Int J Oncol 26: 641-648, 2005


  8. Shinbo Y, Niki T, Taira T, Ooe H, Takahashi-Niki K, Maita C, Seino C, Iguchi-Ariga SMM, Ariga H: Proper SUMO-1 conjugation is essential to DJ-1 to exert its full activities. Cell Death Differ in press


܏\@C@(VwE])
  1. Sano Y, Date H, Igarashi S, Onodera O, Oyake M, Takahashi T, Hayashi S, Morimatsu M, Takahashi H, Makifuchi T, Fukuhara N, Tsuji S: Aprataxin, the causative protein for early-onset ataxia with ocular motor apraxia and hypoalbuminemia, is a nuclear protein with a potential role as a DNA repair protein.Ann Neurol 55: 241-249, 2004


  2. Date H, Igarashi S, Sano Y, Takahashi T, Takahashi T, Takano H, Tsuji S, Nishizawa M, Onodera O: The FHA domain of aprataxin interacts with the C-terminal region of XRCC1. Biochem Biophys Res Commun 325: 1279-1285, 2004


rJ@T@(wEw)
  1. Baba A, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Different Ca2+ dynamics between isolated hippocampal pyramidal cells and dentate granule cells. J Neurocytol 31: 41-48, 2002


  2. Nakao K, Ikegaya Y, Yamada MK, Nishiyama N, Matsuki N: Hippocampal long-term depression as an index of spatial working memory. Eur J Neurosci 16: 970-914, 2002


  3. Ikegaya Y, Matsuura S, Ueno S, Baba A, Yamada MK, Nishiyama N, Matsuki N: βAmyloid enhances glial glutamate uptake activity and attenuates synaptic efficacy. J Biol Chem 277: 32180-32186, 2002


  4. Yamada MK, Nakanishi K, Ohba S, Nakamura T, Ikegaya Y, Nishiyama N, Matsuki N: Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons. J Neurosci 22: 7580-7585, 2002


  5. Ikegaya Y, Ishizaka Y, Matsuki N: BDNF attenuates hippocampal LTD via activation of phospholipase C: Implications for a vertical shift in the frequency-response curve of synaptic plasticity. Eur J Neurosci 16: 145-148, 2002


  6. Ikegaya Y, Matsuki N: Vasopressin induces emesis in Suncus murinus. Jpn J Pharmacol 89: 324-326, 2002


  7. Kim J-A, Mitsukawa K, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Cytoskeleton disruption causes apoptotic degeneration of dentate granule cells in hippocampal slice cultures. Neuropharmacology 42: 1109-1118, 2002


  8. Ueno S, Tsukamoto M, Hirano T, Kikuchi K, Yamada MK, Nishiyama N, Nagano T, Matsuki N, Ikegaya Y: Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-D-aspartate receptor activity in hippocampal CA3 circuits. J Cell Biol 158: 215-220, 2002


  9. Ikegaya Y, Matsuki N: Regionally selective neurotoxicity of NMDA and colchicine is independent of hippocampal neural circuitry. Neuroscience 113: 253-256, 2002


  10. Ikegaya Y, Koyama R,Yamada MK, Nishiyama N, Matsuki N: Rapid regrowth of hippocampal mossy fibres and preceding maturation of NMDA receptor-mediated neurotransmission. Eur J Neurosci 15: 1859-1862, 2002


  11. Iwahori Y, Ikegaya Y, Matsuki N: Hyperpolarization-activated current I(h) in nucleus of solitary tract neurons: Regional difference in serotonergic modulation. Jpn J Pharmacol 88: 459-462, 2002


  12. Koyama R, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Group II metabotropic glutamate receptor activation is required for normal hippocampal mossy fibre development in the rat. J Physiol 539: 157-162, 2002


  13. Matsuura S, Ikegaya Y, Yamada MK, Nishiyama N, Matsuki N: Endothelin downregulates the glutamate transporter GLAST in cAMP-differentiated astrocytes in vitro. Glia 37: 178-182, 2002


  14. Baba A, Mitsumori K, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: β-Amyloid prevents excitotoxicity via recruitment of glial glutamate transporters. Naunyn Schmiedebergs Arch Pharmacol 368: 234-238, 2003


  15. Baba A, Yasui T, Fujisawa S, Yamada RX, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Activity-evoked capacitative Ca2+ entry: Implications in synaptic plasticity. J Neurosci 23: 7737-7741, 2003


  16. Kim J-A, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Mossy fiber pathfinding in multilayer organotypic cultures of rat hippocampal slices. Cell Mol Neurobiol 23: 115-119, 2003


  17. Tsukamoto M, Yasui T, Yamada MK, Nishiyama N, Matsuki N, Ikegaya Y: Mossy fibre synaptic NMDA receptors trigger non-Hebbian long-term potentiation at entorhino-CA3 synapses in the rat. J Physiol 546: 665-675, 2003


  18. Nakao K, Ikegaya Y, Yamada MK, Nishiyama N, Matsuki N: Fimbrial control of bidirectional synaptic plasticity of medial perforant path-dentate transmission. Synapse 47: 163-168, 2003


  19. Ikegaya Y, Delcroix I Iwakura Y, Matsuki N, Nishiyama N: Interleukin-1α abrogates long-term depression of hippocampal CA1 synaptic transmission. Synapse 47: 54-57, 2003


ΐ@Ԗ@(ȎȑwEwa@E_o)
  1. Ishikawa K, Nagaoka U, Takashima M, Yoshizawa K, Yoshizawa T, Ishikawa M, Yamawaki T, Shoji S, Mizusawa H: A gene on SCA4 locus causes dominantly inherited pure cerebellar ataxia. Neurology 54: 1971-1975, 2000


  2. Takashima M, Ishikawa K, Nagaoka U, Shoji S, Mizusawa H: A linkage disequilibrium at the candidate gene locus for the 16q-linked autosomal dominant cerebellar ataxia type III in Japan. J Hum Genet 46: 167-171, 2001


  3. Ishikawa K, Owada K, Ishida K, Fujigasaki H, Shun Li M, Tsunemi T, Ohkoshi N, Toru S, Mizutani T, Hayashi M, Arai N, Hasegawa K, Kawanami T, Kato T, Makifuchi T, Shoji S, Tanabe T, Mizusawa H: Cytoplasmic and nuclear polyglutamine aggregates in SCA6 Purkinje cells. Neurology 56: 1753-1756, 2001


  4. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T: Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem 277: 7214-7221, 2002


  5. Tomimitsu H, Shimizu J, Ishikawa K, Ohkoshi N, Kanazawa I, Mizusawa H: Distal myopathy with rimmed vacuoles: novel mutations in the GNE gene. Neurology 59: 451-454, 2002


  6. Li M, Ishikawa K, Toru S, Tomimitsu H, Takashima M, Goto J, Takiyama Y, Sasaki H, Imoto I, Inazawa J, Toda T, Kanazawa I, Mizusawa H: Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan. J Hum Genet 48: 111-118, 2003


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  8. Yashima T, Noguchi Y, Ishikawa K, Mizusawa H, Kitamura K: Mutation of the EYA1 gene in patients with branchio-oto syndrome. Acta Otolaryngol 123: 279-282, 2003


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  6. Ishiguro H, Yamada K, Sawada H, Nishii K, Ichino N, Sawada M, Kurosawa Y, Matsushita N, Kobayashi K, Goto J, Hashida H, Masuda N, Kanazawa I, Nagatsu T: Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene. J Neurosci Res 65: 289-297, 2001


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  1. Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, Nagatsu T: Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain. J Neural Transm 107: 335-341, 2000


  2. Hibiya M, Ichinose H, Ozaki N, Fujita K, Nishimoto T, Yoshikawa T, Asano Y, Nagatsu T: Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromotography. J Chromatogr B 740: 35-42, 2000


  3. Shen Y, Muramatsu SI, Ikeguchi K, Fujimoto KI, Fan DS, Ogawa M, Mizukami H, Urabe M, Kume A, Nagatsu I, Urano F, Suzuki T, Ichinose H, Nagatsu T, Monahan J, Nakano I, Ozawa K: Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Hum Gene Ther 11: 1509-1519, 2000


  4. Mogi M, Togari A, Tanaka K, Ogawa N, Ichinose H, Nagatsu T: Increase in level of tumor necrosis factor-α in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. Neurosci Lett 289: 165-168, 2000


  5. Tazawa M, Ohtsuki M, Sumi-Ichinose C, Shiraishi H, Kuroda R, Hagino Y, Nakashima S, Nozawa Y, Ichinose H, Nagatsu T, Nomura T: GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression. Comp Biochem Physiol B 127: 65-73, 2000


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  12. Sugimoto T, Ikemoto K, Murata S, Tazawa M, Nomura T, Hagino Y, Ichinose H, Nagatsu T: Identification of (6R)-5,6,7,8-tetrahydro-D-monopterin (=(6R)-2-amino-5,6,7,8-tetrahydro-6-[(1R,2R)-1,2,3-trihydroxypropyl]-pteridin-4(3H)-one) as the native pteridine in Tetrahymena pyriformis. Helv Chim Acta 84: 918-927, 2001


  13. Sumi-Ichinose C, Urano F, Kuroda R, Ohye T, Kojima M, Tazawa M, Shiraishi H, Hagino Y, Nagatsu T, Nomura T, Ichinose H: Catecholamines and serotonin are differently regulated by tetrahydrobiopterin: a study from 6-pyruvoyltetrahydropterin synthase knockout mice. J Biol Chem 276: 41150-41160, 2001


  14. Ohye T, Ichinose H, Yoshizawa T, Kanazawa I, Nagatsu T: A new splicing variant for human tyrosine hydroxylase in the adrenal medulla. Neurosci Lett 312: 157-160, 2001


  15. Kawasaki H, Suemori H, Mizuseki K, Watanabe K, Urano F, Ichinose H, Haruta M, Takahashi M, Yoshikawa K, Nishikawa S, Nakatsuji N, Sasai Y: Generation of TH+ dopaminergic neurons and Pax6+ pigmented epithelia from primate ES cells by SDIA. Proc Natl Acad Sci USA 99: 1580-1585, 2002


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  18. Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K: Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther 13: 345-354, 2002


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  5. Yanase H, Moriya K, Mukai N, Kawata Y, Okamoto K, Kato N: Effects of GroESL coexpression on the folding of nicotinoprotein formaldehyde dismutase from Pseudomonas putida F61. Biosci Biotechnol Biochem 66: 85-91, 2002


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  8. Fujii T, Sakai H, Kawata Y, Hata Y: Crystal structure of thermostable aspartase and exploration of functional site in aspartase family. Acta Crystallogr A58, C100, 2002


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  1. Chiba T, Hashimoto Y, Tajima H, Yamada M, Kato R, Niikura T, Terashita K, Schulman H, Aiso S, Kita Y, Matsuoka M, Nishimoto I: Neuroprotective effect of activity-dependent neurotrophic factor, ADNF, agaist toxicity by familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo. J Neurosci Res 78: 542-552, 2004


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  3. Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M, Nishimoto I: Humanin antagonists: dimerizaiton-interfering mutants inhibit neuroprotection of Humanin.  Eur J Neurosci 19: 2356-2364,2004


  4. Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M, Nishimoto I: Expression of N19S-SOD1, an SOD1 mutant found in sporadic amyotrophic lateral sclerosis patients, induces low-grade motoneuronal toxicity. J Neurosci Res 81: 720-729, 2005


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  6. Nagayoshi C, Ishibashi M, Kita Y, Matsuoka M, Nishimoto I, Tokunaga M: Expression, refolding and characterization of human brain serine racemase in Escherichia Coli with N-terminal HIS-tag. Protein Pept Lett 12: 487-490, 2005


  7. Kanekura K, Hashimoto Y, Kita Y, Sasabe J, Aiso S, Nishimoto I, Matsuoka M: A Rac1/phosphatidylinositol-3 kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of ALS2 gene, antagonized Cu/Zn-superoxide dismutase. J Biol Chem 280: 4532-4543, 2005


  8. Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I: A Humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice. J Neurosci Res 79: 714-723, 2005


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  5. Takeda M, Kato H, Takamiya A, Yoshida A, Kiyama H: Injury specific expression of activating transcription factor-3 (ATF-3) in nerve injured retinal ganglion cells, and its co-localized expression with phosphorylated c-Jun. Invest Ophth Vis Sci 41: 2412-2421, 2000


  6. Tanabe K, Tachibana T, Yamashita T, Che YH, Yoneda Y, Ochi T, Tohyama M, Yoshikawa T, Kiyama H: The small GTP-binding protein TC10 promotes growth cone-like formation and nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci 20: 4138-4144, 2000


  7. Nakagomi S, Kiryu-Seo S, Kiyama H: Endothelin converting enzymes and endothelin receptor B mRNAs are expressed in different neural cell species and these mRNAs are coordinately induced in neurons and astrocytes respectively following nerve injury. Neuroscience 101: 441-449, 2000


  8. Gesase AP, Kiyama H: Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection. J Neurocytol 29: 61-66, 2000


  9. Ishida-Yamamoto A, Kato H, Kiyama H, Armstrong DK, Munro CS, Eady RA, Nakamura S, Kinouchi M, Takahashi H, Iizuka H: Mutant loricrin is not crosslinked into the cornified cell envelope but is translocated into the nucleus in loricrin keratoderma. J Invest Dermatol 115: 1088-1094, 2000


  10. Takeda M, Takamiya A, Yoshida A,Kiyama H: Extracellular signal-regulated kinase activation predominantly in Muller cells of retina with endotoxin-induced uveitis. Invest Ophth Vis Sci 43: 907-911, 2002


  11. Takahashi H, Honma M, Ishida-Yamamoto A, Namikawa K, Miwa A, Okado H, Kiyama H, Iizuka H: In vitro and in vivo transfer of bcl-2 gene into keratinocytes suppresses UVB-induced apoptosis. Photochem Photobiol 74: 579-586, 2001


  12. Takahashi H, Honnma M, Ishida-Yamamoto A, Namikawa K,Kiyama H, Iizuka H: Expression of human cystatin A by keratinocytes is positively regulated via the Ras/MEKK1/MKK7/JNK signal transduction pathway but negatively regulated via the Ras/Raf-1/MEK1/ERK pathway.J Biol Chem276: 36632-36638, 2001


  13. Takamiya A, Takeda M, Yoshida A, Kiyama H: Expression of serine protease inhibitor 3 in ocular tissues in endotoxin induced uveitis in rat. Invest Ophth Vis Sci 42: 2427-2433, 2001


  14. Iida N, Namikawa K, Kiyama H, Ueno H, Nakamura S, Hattori S: Requirement of Ras for the activation of mitogen-activated protein (MAP) kinase by calcium influx, cAMP and neurotrophin in hippocampal neurons. J Neurosci 21: 6459-6466, 2001


  15. Takeda M, Mori F, Yoshida A, Takamiya A, Nakagomi S, Sato E, Kiyama H: Constitutive nitricoxide synthase is associated with retinal vascular permeability in early diabetic rats. Diabetologia44: 1043-1050, 2001


  16. Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15: 1218-1220, 2001


  17. Shirotani K, Tsubuki S, Iwata N, Takaki Y, Harigaya W, Maruyama K, Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases J Biol Chem 276: 21895-21901, 2001


  18. Abe K, Namikawa K, Honma M, Iwata T, Matsuoka I, Watabe K,Kiyama H: Inhibition of Ras-extracellular signal-regulated kinase (ERK) mediated signaling promotes ciliary neurotrophic factor (CNTF) expression in Schwann cells. J Neurochem 77: 700-703, 2001


  19. Sasaki M, Seo-Kiryu S, Kato R, Kita S, Kiyama H: A disintegrin and metalloprotease with thrombospondin type1 motifs (ADAMTS-1) and IL-1 receptor type 1 mRNAs are simultaneously induced in nerve injured motor neurons. Mol Brain Res 89: 158-163, 2001


  20. Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Ogihara T, Vitek MP, Tohyama M: Activated CREB regulates neuronal expression of presenilin-1. J Biol Chem 276: 9688-9698, 2001


  21. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276: 5256-5264, 2001


  22. Kato R, Kiryu-Seo S, Kiyama H: Damage induced neuronal endopeptidase (DINE/ECEL) expression is regulated by LIF and deprivation of NGF in rat sensory ganglia after nerve injury. J Neurosci 22: 9410-9418, 2002


  23. Aoki S, Su QN, Hang L, Nishikawa K, Ayukawa K, Hara Y, Namikawa K, Kiryu-Seo S, Kiyama H, Wada K: Identification of a novel axotomy-induced glycosylated protein, AIGP1, possibly involved in cellular apoptosis triggered by ER-Golgi stress. J Neurosci 22: 10751-10760, 2002


  24. Honma M, Namikawa K, Mansur K, Iwata T, Mori N, Iizuka H, Kiyama H: Developmental alteration of nerve injury induced glial cell line-derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate. J Neurochem 82: 961-976, 2002


  25. Iwata T, Namikawa K, Honma M, Mori N, Yachiku S, Kiyama H: Increased expression of mRNAs for microtubule disassembly molecules during nerve regeneration. Mol Brain Res 102: 105-109, 2002


  26. Takamiya A, Takeda M, Yoshida A, Kiyama H: Inflammation induces serine protease inhibitor 3 (SPI-3) expression in the rat pineal gland. Neuroscience 113: 387-394, 2002


  27. Osaka H, Wang YL, Takada K, Takizawa S, Setsuie R, Li H, Sato Y, Nishikawa K, Sun YJ, Sakurai M, Harada T, Hara Y, Kimura I, Chiba S, Namikawa K,Kiyama H, Noda M, Aoki S, Wada K: Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet 12: 1945-1958, 2003


  28. KatoR, Kiryu-SeoS, SatoY, HisasueS, TsukamotoT, KiyamaH: Cavernous nerve injury elicits GAP-43 mRNA expression but not regeneration of injured pelvic ganglion neurons. Brain Res 986: 166-173, 2003


  29. Suzuki Y, Nakagomi S, Namikawa K, Kiryu-Seo S, Inagaki N, Kaibuchi K, Aizawa H, Kikuchi K, Kiyama H: Collapsin response mediator protein-2 accelerates axon regeneration of nerve-injured motor neurons of rat. J Neurochem 86: 1042-1050, 2003


  30. Ohba N, Maeda M, Nakagomi S, Muraoka M, Kiyama H: Biphasic expression of activating transcription factor-3 in neurons after cerebral infarction. Mol Brain Res 115: 147-156, 2003


  31. Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H: Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. J Neurosci 23: 5187-5196, 2003


r@BY@(kCwEw@w)
  1. Mitsui C, Sakai K, Ninomiya T, Koike T: Involvement of TLCK-sensitive serine protease in colchicine-induced cell death of sympathetic neurons in culture. J Neurosci Res 66: 601-611, 2001


  2. Saitoh T, Tanaka S, Koike T: Rapid unduction and Ca(2+) influx-mediated suppression of vitamin D3 up-regulated rotain 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis. J Neurochem 78: 1267-1276, 2001


  3. Tanaka S, Koike T: Activation of protein kinase C delays apoptosis of nerve growth factor-deprived rat sympathetic neurons through a Ca(2+)-influx dependent mechanism. Neurosci Lett 313: 9-12, 2001


  4. Kaya N, Tanaka S, Koike T: ATP selectively suppresses the synthesis of the inflammatory protein microglial response factor (MRF)-1 through Ca(2+) influx via P2X(7) receptors in cultured microglia. Brain Res 952: 86-97, 2002


  5. Tanaka S, Koike T: Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. Glia 40: 360-371, 2002


@~@(RwEw@㎕w)
  1. Shibuta S, Kosaka J, Inoue T, Shimizu T, Tomi K, Mashimo T: The influence of the timing of administration of thiopentone sodium on nitric oxide-mediated neurotoxicity in vitro. J Neurol Sci 174: 9-15, 2000


  2. Wakabayashi T, Kosaka J, Hommura S.: Up regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina. Neurosci Lett 318: 77-80, 2002


@KY@(LwEw@㎕w)
  1. Matsubayashi H, Amano T, Seki T, Sasa M, Sakai N: Postsynaptic α4 β2 and α7 type nicotinic acetylcholine receptors (nAChRs) contribute to the local and endogenous acetylcholine-mediated synaptic transmissions in nigral dopaminergic neurons. Brain Res 1005: 1-8, 2004


  2. Uchino M, Sakai N, Kashiwagi K, Shirai Y, Shinohara Y, Hirose K, Iino M, Yamamura T, Saito N: Isoform-specific phosphorylation of mGluR5 by PKC blocks Ca2+ oscillation and oscillatory translocation of Ca2+-dependent PKC. J Biol Chem 279: 2254-2261, 2004


  3. Seki T, Matsubayashi H, Amano T, Kitada K, Serikawa T, Sasa M, Sakai N: Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats. Neurochem Int 45: 171-178, 2004


  4. Kajimoto T, Shirai Y, Sakai N, Yamamoto T, Matsuzaki H, Kikkawa U, Saito N: Ceramide-induced apoptosis by translocation, phosphorylation and activation of protein kinase Cδ at Golgi complex. J Biol Chem 279: 12668-12676, 2004


  5. Yagi K, Shirai Y, Hirai M, Sakai N, Saito N: Phospholipase A2 products retain a neuron specific γ isoform of PKC on the plasma membrane through the C1 domain -A molecular mechanism for sustained enzyme activity. Neurochem Int 45: 39-47, 2004


  6. Bhattacharjee AK, Ueyama T, Kondoh T, Hayashi S, Abouelfetouh A, Sakai N, Saito N, Kohmura E: In vivo transgene expression using an adenoviral tetracycline-regulated system with neuron-specific enolase promoter. Biochem Biophys Res Commun 317: 1144-1148, 2004


  7. Amano T, Aihua Z, Matsubayasi H, Seki T, Serikawa T, Sasa M, Sakai N: Antiepileptic effects of single and repeated oral administrations of S-312-d, a novel calcium channel antagonist, on tonic convulsions in spontaneously epileptic rats (SER). J Pharmacol Sci 95: 355-362, 2004


  8. Matsubayashi H, Inoue A, Amano T, Seki T, Nakata Y, Sasa M, Sakai N: Involvement of alpha7- and alpha4beta2 type postsynaptic nicotinic acetylcholine receptors in nicotine-induced excitation of dopaminergic neurons in the substantia nigra: A patch clamp and single-cell PCR study using acutely dissociated nigral neurons. Mol Brain Res 129: 1-7, 2004


  9. Sakai N, Tsubokawa H, Matsuzaki M, Kajimoto T, Takahashi E, Ren Y, Ohmori S, Shirai Y, Matsubayashi H, Chen J, Duman RS, Kasai H, Saito N: Propagation of γPKC translocation along the dendrites of Purkinje cell in γPKC-GFP transgenic mice. Genes Cells 9: 945-957, 2004


  10. Ueyama T, Lennartz MR, Noda Y, Kobayashi T, Shirai Y, Rikitake K, Yamasaki T, Hayashi S, Sakai N, Seguchi H, Sawada M, Sumimoto H, Saito N: Superoxide production at phagosomal cup/phagosome through beta I protein kinase C during Fc gamma R-mediated phagocytosis in microglia. J Immunol 173: 4582-4589, 2004


  11. Mochizuki H, Amano T, Seki T, Matsubayashi H, Mitsuhata C, Morita K, Kitayama S, Dohi T, Mishima HK, Sakai N: Role of C-terminal region in the functional regulation of rat serotonin transporter (SERT). Neurochem Int 46: 93-105, 2005


  12. Seki T, Matsubayashi H, Amano T, Shirai Y, Saito N, Sakai N: Phosphorylation of PKC activation loop plays an important role in receptor-mediated translocation of PKC. Genes Cells 10: 225-239, 2005


  13. Fukunaga-Takenaka R, Shirai Y, Yagi K, Adachi N, Sakai N, Merino E, Merida I, Saito N: Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase α by d-α-tocopherol. Genes Cells 10: 311-319, 2005


  14. Abdel-Raheem IT, Hide I, Yanase Y, Shigemoto-Mogami Y, Sakai N, Shirai Y, Saito N, Hamada FM, El-Mahdy NA, Elsisy Ael-D, Sokar SS, Nakata Y: Protein kinase Cα mediates TNF release process in RBL-2H3 mast cells. Br J Pharmacol 145: 415-423, 2005


  15. Kodama N, Murata Y, Asakawa A, Inui A, Hayashi M, Sakai N, Nanba H: Maitake D-Fraction enhances antitumor effects and reduces immunosuppression by mitomycin-C in tumor-bearing mice. Nutrition 21: 624-629, 2005


@A@(wEw@㎕w)
  1. Li A, Sakaguchi S, Shigematsu K, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S: Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic to Purkinje cell degeneration. Am J Pathol 157: 1447-1452, 2000


  2. Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Shigematsu K: Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene. Cell Mol Neurobiol 20: 553-567, 2000


  3. Valenti P, Cozzio A, Nishida N, Wolfer DP, Sakaguchi S, Lipp HP: Similar target, different effects: late-onset ataxia and spatial learning in prion protein-deficient mouse lines. Neurogenetics 3: 173-184, 2001


  4. Atarashi R, Sakaguchi S, Shigematsu K, Arima K, Okimura N, Yamaguchi N, Li A, Kopacek J, Katamine S: Abnormal activation of glial cells in the brains of prion protein-deficient mice ectopically expressing prion protein-like protein, PrPLP/Dpl. Mol Med 7: 803-809, 2001


  5. Atarashi R, Nishida N, Shigematsu K, Goto S, Kondo T, Sakaguchi S, Katamine S: Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/Doppel-induced neurodegeneration. J Biol Chem 278: 28944-28949, 2003


  6. Yamaguchi N, Sakaguchi S, Shigematsu K, Okimura N, Katamine S: Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein. Biochem Biophys Res Commun 319: 1247-1252, 2004


X؁@G@(kCwEw@w)
  1. Yabe I, Sasaki H, Takeichi N, Takei A, Hamada T, Fukushima K, Tashiro K: Positional vertigo and macroscopic downbeat positioning nystagmus in spinocerebellar ataxia type 6 (SCA6). J Neurol 250: 440-443, 2003


  2. Yabe I, Sasaki H, Chen D, Wendy H. Raskind, Thomas D. Bird, Yamashita I, Tsuji S, Kikuchi S, Tashiro KF Spinocerebellar ataxia type 14 caused by a mutation in protein kinase Cγ. Arch Neurol 60: 1749-1751, 2003


@P@(QwEw)
  1. Suzuki A, Kondo T, Otani K, Mihara K, Yasui-Furukori N, Sano A, Koshiro K, Kaneko S:Association of the TaqI A polymorphism of the dopamine D (2) receptor gene with predisposition to neuroleptic malignant syndrome. Am J Psychiat 158: 1714-1716, 2001


  2. Ueno S, Maruki Y, Nakamura M, Tomemori Y, Kamae K, Tanabe H, Yamashita Y, Matsuda S, Kaneko S, Sano A: The gene encoding a newly discovered protein, chorein, is mutated in chorea-acanthocytosis. Nat Genet28: 121-122, 2001


  3. Sakai K, Nakamura M, Ueno S, Sano A, Sakai N, Shirai Y, Saito N: The silencer activity of the novel human serotonin transporter linked polymorphic regions. Neurosci Lett 327: 13-16, 2002


  4. Sano A, Mikami M, Nakamura M, Ueno S, Tanabe H, Kaneko S: Positional candidate approach for the gene responsible for benign adult familial myoclonic epilepsy. Epilepsia 43 Suppl 9: 26-31, 2002


@T@(swEw@wȁE[̈Zw@\)
  1. Nagai Y, Sano H, Yokoi MFTransgenic expression of Cre recombinase in mitral/tufted cells of the olfactory bulb. Genesis 43: 12-16, 2005


ēc@G@(wEw@wn)
  1. Ohsawa Y, Zhang G, Kametaka S, Shibata M, Koike M, Waguri S, Uchiyama Y: Purification, cDNA cloning, and secretory properties of FLRG protein from PC12 cells and the distribution of FLRG mRNA and protein in rat tissues. Arch Histol Cytol 66: 367-381, 2003


  2. Zhang G, Ohsawa Y, Kametaka S, Shibata M, Waguri S, Uchiyama Y: Regulation of FLRG expression in rat primary astroglial cells and injured brain tissue by transforming growth factor-beta 1 (TGF-beta 1). J Neurosci Res 72: 33-45, 2003


  3. Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y: Identification of phospholipid scramblase 1 as a novel interacting molecule with beta-secretase (beta-site amyloid precursor protein (APP) cleaving enzyme (BACE)). J Biol Chem 278: 15239-15245, 2003


؁@r@(sՏw)
  1. Park KC, Choi EJ, Min SW, Chung SS, Kim H, Suzuki T, Tanaka K, Chung CH: Tissue specificity, functional characterization, and subcellular localization of rat ubiquitin-specific protease, UBP109, whose mRNA expression is developmentally regulated. Biochem J 349: 443-453, 2000


  2. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinsonfs disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305, 2000


  3. Osaka F, Saeki M, Aida N, Toh-e A, Katayama S, Kominami K, Toda T, Suzuki T, Chiba T, Tanaka K, Kato S: Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J 19: 1-10, 2000


  4. Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, Uchida S, Shimbara N, Saitoh H, Tanaka K, Chung CH: A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 275: 14102-14106, 2000


  5. Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K: Homodimer of two F-box proteins βTrCP1 or βTrCP2 binds to IκBα for signal-dependent ubiquitination. J Biol Chem 275: 2877-2884, 2000


  6. Takabe W, Kodama T, Hamakubo T, Tanaka K, Suzuki T, Aburatani H, Matsukawa N, Noguchi N: Anti-atherogenic antioxidants regulate the expression and function of proteasome α-type subunits in human endothelial cells. J Biol Chem 276: 40497-40501, 2001


  7. Wang M, Suzuki T, Kitada T, Asakawa S, Minoshima S, Shimizu N, Tanaka K, Mizuno Y, Hattori N: Developmental changes in the expression of parkin and UbcR7, a parkin-interacting and ubiquitin-conjugating enzyme, in rat brain. J Neurochem 77: 1561-1568, 2001


  8. Niwa J, Ishigaki S, Doyu M, Suzuki T, Tanaka K, Sobue G: A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun 281: 706-713, 2001


  9. Matsuda N, Suzuki T, Tanaka K, Nakano A: Rma1, a novel RING-finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. J Cell Sci 114: 1949-1957, 2001


  10. Kawakami T, Chiba T, Suzuki T, Iwai K, Yamanaka K, Minato N, Hidaka Y, Shimbara N, Suzuki H, Osaka. F, Omata M, Tanaka K: NEDD8 recruits E2-ubiquitin to SCF E3-ligase. EMBO J 20: 4003-401, 2001


  11. Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K, Tai T: E3 ubiquitin ligase that recognizes sugar chains. Nature 418: 438-442, 2002


  12. Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A: Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin. Mol Cell Biol 22: 3803-3819, 2002


  13. Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y: Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 277: 21843-21850, 2002


  14. Araki K, Kawamura M, Suzuki T, Matsuda N, Kanbe D, Ishii K, Ichikawa T, Kumanishi T, Chiba T, Tanaka K, Nawa H: A palmitoylated RING finger ubiquitin ligase and its homologue, boh enriched in the brain membranes. J Neurochem 86: 749-762, 2003


@Ǖ@(wE]ȊwZ^[)
  1. Kawata A, Kato S, Shimizu T, Hayashi H, Hirai S, Misawa H, Takahashi R: Aberrant splicing of human Cu/Zn superoxide dismutase (SOD1) RNA transcripts. NeuroReport 11: 2649-2653, 2000


  2. Imai Y, Soda M, Takahashi R: Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275: 35661-35664, 2000


  3. Suzuki Y, Nakabayashi Y, Nakata K, Reed JC, Takahashi R: X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes. J Biol Chem 276: 27058-27063, 2001


  4. Suzuki Y, Nakabayashi Y, Takahashi R: Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 98: 8662-8667, 2001


  5. Imai Y, Soda M, Inoue H, Hattori N, Mizuno Y, Takahashi R: An unfolded putative membrane transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin. Cell 105: 891-902, 2001


  6. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R: Aserine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8: 613-621, 2001


  7. Ishida K, Takeuchi H, Takahashi R, Yoshimura K, Yamada M, Mizusawa H: A possible novel isoform of peripheral myelin P0 protein: a target antigen recognized by an autoantibody in a patient with malignant lymphoma and peripheral neuropathy. J Neurol Sci 188: 43-49, 2001


  8. Araya R, Takahashi R, Nomura Y: Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28γ as an effector caspase substrate. Cell Death Differ 9: 322-328, 2002


  9. Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama KI, Takahashi R: CHIP is associated with Parkin, a gene responsible for familial Parkinsones disease, and enhances its ubiquitin ligase activity. Mol Cell 10: 55-67, 2002


  10. Kobayashi S, Yamashita K, Takeoka T, Ohtsuki T, Suzuki Y, Takahashi R, Yamamoto K, Kaufmann SH, Uchiyama T, Sasada M, Takahashi A: Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem 277: 33968-33977, 2002


  11. Urushitani U, Kurisu J, Tsukita K, Takahashi R: Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J Neurochem 83: 1030-1042, 2002


  12. Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem 278: 51901-51910, 2003


  13. Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R: The crucial role of caspase-9 in the disease progression of transgenic ALS mouse model. EMBO J 22: 6665-6674, 2003


  14. Yokota T, Sugawara K, Takahashi R, Ariga H, Mizusawa H: Down regulation of DJ-1 enhances the cell death by oxidative stress, ER-stress and proteasome inhibition. Biochem Biophys Res Commun 312: 1342-1348, 2003


  15. Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B: Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron 37: 911-924, 2003


  16. Misawa H, Nakata K, Toda K, Matsuura J, Oda Y, Inoue H, Taneno M, Takahashi R: VAChT-Cre.Fast and VAChT-Cre.Slow: postnatal expression of Cre recombinase in somatomotor neurons with different onset. Genesis 37: 44-50, 2003


  17. Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R: The mitochondrial protease Omi-HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11: 208-216, 2004


  18. Yokota T, Miyagishi M, Hino T, Matsumura R, Andria T, Urushitani M, Rao RV, Takahashi R, Bredesen DE, Taira K, Mizusawa H: siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme. Biochem Biophys Res Commun 314: 283-291, 2004


  19. Murakami T, Shoji M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R, Abe K: Pael-R is accumulated in Lewy bodies of Parkinsonfs disease. Ann Neurol 55: 439-442, 2004


  20. Urushitani M, Kurisu J, Tateno M, Hatakeyama S, Nakayama KI, Kato S, Takahashi R: CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70. J Neurochem 90: 231-244, 2004


  21. Hosokawa Y, Suzuki H, Suzuki Y, Takahashi R, Seto M: Anti-apoptotic function of API2-MALT1 fusion protein involved in t(11;14)(q21;q21) MALT lymphoma. Cancer Res 64: 3452-3457, 2004


  22. Vyas S, Juin P, Hancock D, Suzuki Y, Takahashi R, Triller A, Evan G: Differentiation dependent sensitivity to apoptogenic factors in PC12 cells. J Biol Chem 279: 30983-30993, 2004


  23. Tateno M, Sadakata H, Tanaka M, Itohara S, Shin RM, Miura M, Masuda M, Aosaki T, Urushitani M, Misawa H, Takahashi R: Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum Mol Genet 13: 2183-2196, 2004


  24. Yamamoto A, Friedlein A, Imai Y, Takahashi R, Kahle PJ, Haass C: Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J Biol Chem 280: 3390-3399, 2005


  25. Hatakeyama S, Matsumoto M, Kamura T, Murayama M, Chui DH, Planel E, Takahashi R, Nakayama KI, Takashima A: U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem 91: 299-307, 2004


  26. Kim YJ, Nakatomi R, Akagi T, Hashikawa T, Takahashi R: Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants. J Biol Chem 280: 21515-21521, 2005


c粁@ׁ@iȎȑwEw@㎕wȁj
  1. Kurihara T, Nonaka T, Tanabe T: Acetic acid-conditioning stimulus induces long-lasting antinociception of somatic inflammatory pain. Pharmacol Biochem Behav74: 841-849, 2003


  2. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel. Anesth Analg97: 96-103, 2003


  3. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Neurosci Lett350: 41-45, 2003


  4. Yokoyama K, Kurihara T, Makita K, Tanabe T: Plastic change of N-type Ca channel expression after preconditioning is responsible for prostaglandin E2-induced long-lasting allodynia. Anesthesiology 99: 1364-1370, 2003


  5. Takahashi E, Fukuda K, Miyoshi S, Murta M, Kato T, Ita M, Tanabe T, Ogawa S: Leukemia inhibitory factor activates cardiac L-type Ca2+ channels via phosphorylation of serine 1829 in the rabbit CaV1.2 subunit. Circ Res 94: 1242-1248, 2004


  6. Yokoyama K, Kurihara T, Saegusa H, Zong S, Makita K, Tanabe T: Blocking the R-type (CaV2.3) Ca2+ channel enhanced morphine analgesia and reduced morphine tolerance. Eur J Neurosci 20: 3516-3519, 2004


@vq@iwEw@wnȁj
  1. Hamada T, Ui-Tei K, Imaki J, Miyata Y: Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/fallotein. Biochem Biophys Res Commun 280: 733-737, 2001


  2. Piao Z-f, Ui-Tei K, Nagano M, Miyata Y: Participation of intracellular Ca2+/calmodulin and protein kinase(s) in the pathway of apoptosis induced by a Drosophila cell death gene. Mol Cell Biol Res Commun 4: 307-312, 2001


  3. Hamada T, Ui-Tei K, Imaki J, Takahashi F, Onodera H, Mishima T, Miyata Y: The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. Mech Dev 112: 161-164, 2002


  4. Seike M, Gemma A, Hosoya x, Hosomi Y, Okano T, Kurimoto F, Uematsu K, Tekenaka K, Yoshimura A, Shibuya M, Ui-Tei K, Kudoh S: The pomoter region of the human BUBR1 gene and its expression analysis in lung cancer. Lung Cancer 38: 229-234, 2002


  5. Uwo M.F, Ui-Tei K, Park P, Takeda M: Replacement of midgut epithelium in the greater wax moth, Galleria mellonela, during larval-pupal moult. Cell Tissue Res 308: 319-331, 2002


  6. Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K: Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol 13: 41-46, 2003


  7. Iwabushi M, Ui-Tei K, Yamada K, Matsuda Y, Sakai Y, Tanaka K, Ohki-Hamazaki H: Molecular cloning and characterization of avian bombesin-like peptide receptors: New tools for investigating molecular bais for ligand selectivity. Br J Pharmacol 139: 555-566, 2003


  8. Kato M, Ui-Tei K, Watanabe M, Sakuma Y: Characterization of voltage-gated calcium currents in gonadotropin-releasing hormone neurons tagged with green fluorescent protein in rats. Endocrinology 144: 5118-5125, 2003


  9. Mishima T, Hamada T, Ui-Tei K, Takahashi F, Miyata Y, Imaki J, Suzuki H, Yamashita K: Expression of DDAH1 in chick and rat embryos. Dev Brain Res 148: 223-232, 2004


  10. Ui-Tei K, Ueda R, Zenno S, Takahashi F, Doi N, Naito Y, Yamamoto M, Hashimoto N, Takahashi K, Hamada T, Tokunaga T, Saigo K: RNA interference induced by transient or stable expression of hairpin structures of double stranded RNA in Drosophila and mammalian cells. Mol Biol (Mosk)38: 276-287, 2004


  11. Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K: Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference. Nucleic Acids Res 32: 936-948, 2004


  12. Takagi Y, Momizu M, Ui-Tei K, Tokushige N, Hirohashi S: Active sites in the carboxyl-terminal region of the laminn a chain in Drosophila Neuronal cell spreading. Arch Insect Biochem Physiol 56: 162-169, 2004


  13. Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K: siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference. Nucleic Acids Res 32: W124-W129, 2004.


  14. Niimura M, Isoo N, Takasugi N, Tsuruoka M, Ui-Tei K, Saigo K, Morohashi Y, Tomita T, Iwatsubo T: Aph-1 contributes to the stabilization and trafficking of the γ-secretase complex through mechanisms involving inter- and intramolecular interactions. J Biol Chem 280: 12967-12975, 2005


  15. Takahashi M, Takahashi F, Ui-Tei K, Kojima T, Saigo K: Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. Development 132: 2547-2559, 2005


  16. Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S: dsCheck: highly sensitive off-target search software for dsRNA-mediated RNA interference. Nucleic Acids Res 33: W589-W591, 2005


R@\@iwEw@wnȁj
  1. Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M: Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein. J Biol Chem 275: 11114-11120, 2000


  2. Taniguchi M, Yamashita T, Kumura E, Tamatani M, Kobayashi A, Yokawa T, Maruno M, Kato A, Ohnishi T, Kohmura E, Tohyama M, Yoshimine T: Induction of aquaporin-4 water channel mRNA after focal cerebral ischemia in rat. Mol Brain Res 78: 131-137, 2000


  3. Tanabe K, Tachibana T, Yamashita T, Che Y. H., Yoneda Y, Ochi T, Tohyama M, Yoshikawa H, Kiyama H: The small GTP-binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci 20: 4138-4144, 2000


  4. Tamatani M, Mitsuda N, Matsuzaki H, Okado H, Miyake S, Vitek M. P., Yamaguchi A, Tohyama M: A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. J Neurochem 75: 683-693, 2000


  5. Takakuwa T, Endo S, Shirakura Y, Yokoyama M, Tamatani M, Tohyama M, Aozasa K, Inada K: Interleukin-10 gene transfer improves the survival rate of mice inoculated with Escherichia coli. Crit Care Med 28: 2685-2689, 2000


  6. Morihara T, Katayama T, Sato N, Yoneda T, Manabe T, Hitomi J, Abe H, Imaizumi K, Tohyama M: Absence of endoproteolysis but no effects on amyloid beta production by alternative splicing forms of presenilin-1, which lack exon 8 and replace D257A. Mol Brain Res 85: 85-90, 2000


  7. Mori Y, Imaizumi K, Katayama T, Yoneda T, Tohyama M: Two cis-acting elements in the 3' untranslated region of alpha-CaMKII regulate its dendritic targeting. Nat Neurosci 3: 1079-84, 2000


  8. Miyoshi K, Katayama T, Imaizumi K, Taniguchi M, Mori Y, Hitomi J, Yui D, Manabe T, Gomi F, Yoneda T, Tohyama M: Characterization of mouse Ire1alpha: cloning, mRNA localization in the brain and functional analysis in a neural cell line. Mol Brain Res 85: 68-76, 2000


  9. Kudo T, Imaizumi K, Tanimukai H, Katayama T, Sato N, Nakamura Y, Tanaka T, Kashiwagi Y, Jinno Y, Tohyama M, Takeda M: Are cerebrovascular factors involved in Alzheimerfs disease? Neurobiol Aging 21: 215-224, 2000


  10. Horimoto M, Sasaki Y, Ugawa S, Wada S, Toyama T, Iyoda K, Yakushijin T, Minami Y, Ito T, Hijioka T, Eguchi A, Nakanishi M, Shimada S, Tohyama M, Hayashi N, Hori M: A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer. Cancer Gene Ther 7: 1341-1347, 2000


  11. Gomi F, Imaizumi K, Yoneda T, Taniguchi M, Mori Y, Miyoshi K, Hitomi J, Fujikado T, Tano Y, Tohyama M: Molecular cloning of a novel membrane glycoprotein, pal, specifically expressed in photoreceptor cells of the retina and containing leucine- rich repeat. J Neurosci 20: 3206-3213, 2000


  12. Che YH, Tamatani M, Yamashita T, Gomi F, Ogawa S, Tohyama M: Changes in mRNA of protein inhibitor of neuronal nitric oxide synthase following facial nerve transection. J Chem Neuroanat 17: 199-206, 2000


  13. Che YH, Tamatani M, Tohyama M: Changes in mRNA for post-synaptic density-95 (PSD-95) and carboxy- terminal PDZ ligand of neuronal nitric oxide synthase following facial nerve transection. Mol Brain Res 76: 325-335, 2000


  14. Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Hori O, Yanagi H, Tamatani M, Tohyama M: 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Am J Physiol Cell Physiol 278: C1172-C1182, 2000


  15. Yui D, Yoneda T, Oono K, Katayama T, Imaizumi K, Tohyama M: Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling. Oncogene 20: 4317-4323, 2001


  16. Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M: Activation of caspase-12, an endoplasmic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2- dependent mechanism in response to the ER stress. J Biol Chem 276: 13935-13940, 2001


  17. Yara S, Kawakami K, Kudeken N, Tohyama M, Teruya K, Chinen T, Awaya A, Saito A: FTS reduces bleomycin-induced cytokine and chemokine production and inhibits pulmonary fibrosis in mice. Clin Exp Immunol 124: 77-85, 2001


  18. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek M. P., Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276: 5256-5264, 2001


  19. Utsumi M, Ohno K, Onchi H, Sato K, Tohyama M: Differential expression patterns of three glutamate transporters (GLAST, GLT1 and EAAC1) in the rat main olfactory bulb. Mol Brain Res 92: 1-11, 2001


  20. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, Tohyama M: ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med 7: 317-323, 2001


  21. Sato N, Imaizumi K, Manabe T, Taniguchi M, Hitomi J, Katayama T, Yoneda T, Morihara T, Yasuda Y, Takagi T, Kudo T, Tsuda T, Itoyama Y, Makifuchi T, Fraser PE, St George-Hyslop P, Tohyama M: Increased production of beta-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. J Biol Chem 276: 2108-2114, 2001


  22. Sakata K, Yamashita T, Maeda M, Moriyama Y, Shimada S, Tohyama M: Cloning of a lymphatic peptide/histidine transporter. Biochem J 356: 53-60, 2001


  23. Ohkubo N, Mitsuda N, Tamatani M, Yamaguchi A, Lee Y. D., Ogihara T, Vitek M. P., Tohyama M: Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway. J Biol Chem 276: 3046-3053, 2001


  24. Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Sakata K, Ogihara T, Vitek MP, Tohyama M: Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. J Biol Chem 276: 9688-9698, 2001


  25. Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15: 1218-1220, 2001


  26. Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, St George-Hyslop, P, Tohyama M: Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimer's disease-linked presenilin 1 mutations. J Biol Chem 276: 43446-43454, 2001


  27. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T: Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95. J Biol Chem 276: 9174-9181, 2001


  28. Imaizumi K, Katayama T, Tohyama M: Presenilin and the UPR. Nat Cell Biol 3: E104, 2001


  29. Imaizumi K, Miyoshi K, Katayama T, Yoneda T, Taniguchi M, Kudo T, Tohyama M: The unfolded protein response and Alzheimerfs disease. Biochim Biophys Acta 1536: 85-96, 2001


@@iRwEw@wȁj
  1. Nakai A, Suzuki M, Tanabe M: Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J 19: 1545-1554, 2000


  2. Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa S, Reed JC, Ishii S: p53 suppresses the c-myb-induced activation of heat shock transcription factor 3. J Biol Chem 275: 15578-15585, 2000


  3. Nakai A, Ishikawa T: A nuclear localization signal is essential for stress-induced dimer-to-trimer transition of heat shock transcription factor 3. J Biol Chem 275: 34665-34671, 2000


  4. Nakai A, Ishikawa T: Cell cycle transition under stress conditions controlled by vertebrate heat shock factors. EMBO J 20: 2885-2895, 2001


  5. Nishizawa J, Nakai A, Komeda M, Ban T, Nagata K: Increased preload directly induces the activation of heat shock transcription factor 1 in the left ventricular overloaded heart. Cardiovasc Res 55: 341-348, 2002


  6. Shallom JM, Di Carlo AL, Ko D, Penafiel LM, Nakai A, Litovitz TA: Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos. J Cell Biochem 86: 490-496, 2002


i@`@iwEw@wnȁj
  1. Tachikawa M, Nagai Y, Nakamura K, Kobayashi K, Fujiwara T, Han HJ, Nakabayashi Y, Ichikawa Y, Goto J, Kanazawa I, Nakamura Y, Toda T: Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases. J Hum Genet 47: 275-278, 2002


  2. Azuma T, Uemichi T, Funauchi M, Nagai Y, Matsubara T: Ambulatory blood pressure monitoring in patients with spinocerebellar degeneration. Acta Neurol Scand 106: 213-217, 2002


  3. Nagai Y, Fujikake N, Ohno K, Higashiyama H, Popiel HA, Rahadian J, Yamaguchi M, Strittmatter WJ, Burke JR, Toda T: Prevention of polyglutamine oligomerization and neurodegeneration by the peptide inhibitor QBP1 in Drosophila. Hum Mol Genet 12: 1253-1259, 2003


  4. Toda T, Kobayashi K, Takeda S, Sasaki J, Kurahashi H, Kano H, Wang F, Tachikawa M, Nagai Y, Sunada Y, Terashima T, Endo T, Matsumura K: Fukuyama-type congenital muscular dystrophy (FCMD) and α-dystroglycanopathy. Congenit Anom 43: 97-104, 2003


  5. Toda T, Kobayashi K, Takeda S, Sasaki J, Kurahashi H, Kano H, Tachikawa M, Wang F, Nagai Y, Taniguchi K, Taniguchi M, Sunada Y, Terashima T, Endo T, Matsumura K: Fukuyama-type congenital muscular dystrophy and abnormal glycosylation of α-dystroglycan. Basic Appl Myol 13: 287-292, 2003


  6. Popiel HA, Nagai Y, Onodera O, Inui T, Fujikake N, Urade Y, Strittmatter WJ, Burke JR, Ichikawa A, Toda T: Disruption of the toxic conformation of the expanded polyglutamine stretch leads to suppression of aggregate formation and cytotoxicity. Biochem Biophys Res Commun 317: 1200-1206, 2004


  7. Kariya S, Hirano M, Nagai Y, Furiya Y, Fujikake N, Toda T, Ueno S: Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches. J Mol Neurosci 25: 165-170, 2005


  8. Chiyonobu T, Sasaki J, Nagai Y, Takeda S, Funakoshi H, Nakamura T, Sugimoto T, Toda T: Effects of fukutin deficiency in the developing mouse brain. Neuromuscul Disord 15: 416-426, 2005


  9. Fujikake N, Nagai Y, Popiel HA, Kano H, Yamaguchi M, Toda T: Alternative splicing regulates the transcriptional activity of Drosophila heat shock transcription factor in response to heat/cold stress. FEBS Lett 579: 3842-3848, 2005


@@iwEw@wnȁj
  1. Sugai F, Yamamoto Y, Miyaguchi K, Zhou Z, Sumi H, Hamasaki T, Goto M, Sakoda S: Benefit of valproic acid in suppressing disease progression of ALS model mice. Eur J Neurosci 20: 3179-3183, 2004


  2. Nagano S, Huang X, Moir RD, Payton SM, Tanzi RE, Bush AI: Peroxidase activity of cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimerfs disease. J Biol Chem 279: 14673-14678, 2004


  3. Sato T, Yamamoto Y, Nakanishi T, Fukada K, Sugai F, Zhou Z, Okuno T, Nagano S, Hirata S, Shimizu A, Sakoda S: Identification of two novel mutations in the Cu/Zn superoxide dismutase gene with familial amyotrophic lateral sclerosis: mass spectrometric and genomic analyses. J Neurol Sci 218: 79-83, 2004


  4. Puglielli L, Friedlich AL, Setchell KDR, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI: Cholesterol oxidase mimetic activity of Alzheimerfs disease beta-amyloid. J Clin Invest 115: 2556-2563, 2005


  5. Nishioka N, Nagano S, Nakayama R, Kiyonari H, Ijiri T, Taniguchi K, Shawlot W, Hayashizaki Y, Westphal H, Behringer RR, Matsuda Y, Sakoda S, Kondoh H, Sasaki H: Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex. Development 132: 2535-2546, 2005


@_Y@iwEwa@E_oȁj
  1. Nakamura K, Jeong, S-Y, Uchihara T, Anno M, Nagashima K, Nagashima T, Ikeda S, Tsuji S, Kanazawa I: SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet 10: 1441-1448, 2001


  2. Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294: 429-440, 2002


  3. Tachikawa M, Nagai Y, Nakamura K, Kobayashi K, Fujiwara T, Han HJ, Nakabayashi Y, Ichikawa Y, Goto J, Kanazawa I, Nakamura Y, Toda T: Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases. J Hum Genet 47: 275-278, 2002


@dM@iLwEwj
  1. Maruyama H, Izumi Y, Oda M, Torii T, Morino H, Toji H, Sasaki K, Terasawa H, Nakamura S, Kawakami H: Lack of an association of between cystatin C gene polymorphisms in Japanese patients with Alzheimerfs disease. Neurology 57: 337-339, 2001


  2. Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima M, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001


  3. Nakamura T, Yamashita H, Takahashi T, Nakamura S: Activated fyn phosphorylates α-synuclein at tyrosine residue 125. Biochem Biophys Res Commun 280: 1085-1092, 2001


  4. Izumi Y, Morino H, Oda M, Maruyama H, Udaka F, Kameyama M, Nakamura S, Kawakami H: Genetic studies in Parkinsonfs disease with an α-synuclein/NACP gene polymorphism in Japan. Neurosci Lett 300: 125-127, 2001


  5. Yukawa M, Naka H, Murata Y, Katayama S, Kohriyama T, Mimori Y, Nakamura S: Folic acid-responsive neurological diseases in Japan. J Nutr Sci Vitaminol 47: 181-187, 2001


  6. Oka M, Katayama S, Imon Y, Ohshita T, Mimori Y, Nakamura S: Abnormal signals on proton density-weighted MRI of the superior cerebellar peduncle in progressive supranuclear palsy. Acta Neurol Scand 104: 1-5, 2001


  7. Inoue K, Hashimoto I, Nakamura S: High-frequency oscillations in human posterior tibial somatosensory evoked potentials are enhanced in patients with parkinsonfs disease and multiple system atrophy. Neurosci Lett 297: 89-92, 2001


  8. Nishimura M, Kawakami H, Maruyama H, Izumi Y, Kuno S, Kaji R, Nakamura S: Influence of interleukin-1β gene polymorphism on age-at-onset of spinocerebellar ataxia 6 (SCA6). Neurosci Lett 307: 128-130, 2001


  9. Kitae S, Murata Y, Tachiki N, Okazaki M, Harada T, Nakamura S: Assessment of cardiovascular autonomic dysfunction in multiple system atrophy. Clin Auton Res 11: 39-44, 2001


  10. Kato M, Aoki M, Ohta M, Nagai M, Ishizaki F, Nakamura S, Itoyama Y: Maked reducution of the Cu/Zn superoxide dismutase polypeptide in a case of familial amyotrophic lateral sclerosis with the homozygous mutation. Neurosci Lett 312: 165-168, 2001


  11. Harada T, Ishizaki F, Murata Y, Mitsuoka T, Kumagai R, Nitta K, Nakamura S: Clinical characteristics of neuroleptic malignant syndrome in Parkinsonfs disease and other neurological disorders. Int Med J 8: 249-257, 2001


  12. Harada T, Ishizaki F, Tachiki N, Nitta K, Horie N, Matsumoto T, Inoue K, Nakamura S: Evaluation of cardiovascular circadian rhythm in patients with Parkinsonfs disease. Int Med J 8: 263-268, 2001


  13. Harada T, Ishizaki F, Murata Y, Nitta K, Tachiki N, Okazaki M, Nakamura S: Circadian rhythm of blood pressure and pulse rate in diabetes mellitus. Int Med J 8: 281-288, 2001


  14. Mao JJ, Katayama S, Watanabe C, Harada Y, Noda K, Yamamura Y, Nakamura S: The relationship of αB-crystallin and neurofibrillary tangles in Alzheimerfs disease. Neuropathol Appl Neurobiol 27: 180-188, 2001


  15. Nagano Y, Yamashita H, Nakamura T, Takahashi T, Kondo E, Nakamura S: Lack of binding observed between human α-synuclein and Bcl-2 protein family. Neurosci Lett 316: 103-107, 2001


  16. Kozuka K, Kohriyama T, Nomura E, Ikeda J, Kajikawa H, Nakamura SFEndothelial markers and adhesion molecules in acute ischemic stroke-sequential change and differences in stroke subtype. Atherosclerosis 161: 161-168, 2002


  17. Nakamura T, Yamashita H, Nagano Y, Takahashi T, Avraham S, Avraham H, Matsumoto M, Nakamura S: Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases. FEBS Lett 521: 190-194, 2002


  18. Naka H, Imon Y, Ohshita T, Honjo K, Kitamura T, Mimori Y, Nakamura S: Magnetization transfer measurements of cerebral white matter in patients with myotonic dystrophy. J Neurol Sci 193: 111-116, 2002


  19. Ogura H, Yasuda M, Nakamura S, Yamashita H, Mikoshiba K, Ohmori H: Neurotoxic damage of granule cells in the dentate gyrus and the cerebellum and cognitive deficit following neonatal administration of phenytoin in mice. J Neuropathol Exp Neurol 61: 956-967, 2002


  20. Maruyama H, Izumi Y, Morino H, Oda M, Toji H, Nakamura S, Kawakami H: Difference in disease-free survival curve and regional distribution according to subtype of spinocerebellar ataxia: A study of 1,286 Japanese patients. Am J Med Genet 114: 578-583, 2002


  21. Inoue K, Yamashita H, Harada T, Nakamura S: Role of human cortices in sensorimotor integration. Clin Neurophysiol 113: 1573-1578, 2002


  22. Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Toji H, Nakmura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002


  23. Yukawa M, Miyachi T, Ochi H, Katayama S, Kohriyama T, Mimori Y, Nakamura S: Characteristic features of folate-deficient neurological diseases in the elderly. Geriatr Gerontol Int 2: 97-104, 2002


  24. Harada H, Mitsuoka T, Kumagai R, Murata Y, Kaseda Y, Kamei H, Ishizaki F, Nakamura S: Clinical features of malignant syndrome in Parkinsonfs disease and related neurological disorders. Parkinsonism Relat Disord 9: S15-S23, 2003


{@@iwEwj
  1. Ohara S, Ukita Y, Ninomiya H, Ohno K: Degeneration of cholecystokinin-immunoreactive afferents to the VPL thalamus of the mouse model of Niemann-Pick type C. Brain Res 1022: 244-246, 2004


  2. Hou L, Sugimoto Y, Ohsaki Y, Ninomiya H, Oka A, Taniguchi M, Ida H, Eto Y, Ogawa S, Matsuzaki Y, Sawa M, Inoue T, Higaki K, Nanba E, Ohno K, Suzuki Y: N-Octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease. Biochim Biophys Acta 1689: 219-228, 2004


  3. Kato Y, Akai A, Suzuki R, Hosokawa H, Ninomiya H, Masaki T, Nagata K, Tanokura M: 1H, 13C and 15N assignments of the tandem WW domains of human MAGI-1/BAP-1. J Biomol NMR 29: 539-540, 2004


  4. Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimerfs disease. J Neurol Neurosurg Psychiat 75: 1039-1042, 2004


  5. Ohara S, Ukita Y, Ninomiya H, Ohno K: Axonal dystrophy of dorsal root ganglion sensory neurons in a mouse model of Niemann-Pick disease type C. Exp Neurol 187: 289-298, 2004


  6. Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies J.P., Ioannou YA, Ohno K, Ninomiya H: Reduced sensitivity of Niemann-Pick C1-deficient cells to theta-toxin (perfringolysin O): sequestration of toxin to raft-enriched membrane vesicles. Histochem Cell Biol 121: 263-272, 2004


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  2. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, Tohyama M: ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med 7: 317-323, 2001


  3. Okamoto M, Nakajima Y, Matsuyama T, Sugita M: Amyloid precursor protein associates independently and cooperatively with PTB and PDZ domains of mint on vesicles and at cell membrane. Neuroscience 104: 653-665, 2001


  4. Nakajima Y, Okamoto M, Nishimura H, Obata K, Kitano H, Sugita M, Matsuyama T: Neuronal expression of mint1 and mint2, novel multimodular proteins, in adult murine brain. Mol Brain Res 92: 27-42, 2001


  5. Kitada O, Kodama T, Kuribayashi K, Ihaku D, Fujita M, Matsuyama T, Sugita M: Heme oxygenase-1 (HO-1) protein induction in a mouse model of asthma. Clin Exp Allergy 31: 1470-1477, 2001


  6. Kuribayashi K, Kodama T, Okamura H, Sugita M, Matsuyama T: Effects of postinhalation treatment with interleukin (IL)-12 on airway hyperreactivity, eosinophilia, and IL-18 receptor expression in mouse model of asthma. Clin Exp Allergy 32: 641-649, 2002


  7. Miyazaki M, Ozawa K, Hori O, Kitao Y, Matsushita K, Ogawa S, Matsuyama T: Expression of 150-kd oxygen-regulated protein in the hippocampus suppresses delayed neuronal cell death. J Cereb Blood Flow Metab 22: 979-987, 2002


  8. Ma Y, Okamoto M, Gu F, Obata K, Matsuyama T, Desaki J, Tanaka J, Sakanaka M: Neuronal distribution of EHSH1/intersectin: Molecular linker between clathrin-mediated endocytosis and signaling pathways. J Neurosci Res 71: 468-477, 2002


ێR@aq@i×{a@ÌZ^[j
  1. Uezono T, Matsubara K. Maruyama W, Naoi M, Shimizu K, Saito O, Ogawa K, Mizukami H, Hayase N, Shiono H: Norharman, an indoleamine-derived beta-carboline, but not Trp-p-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells. J Neural Transm 108: 943-953, 2001


  2. Toth BE, Homicsko K, Radnai B, Maruyama W, DeMaria JE, Vecsernyes M, Fekete MIK, Fülöp F, Naoi M, Freeman ME, Nagy M: Salsolinol is a putative endogenous neuro-intermediate lobe prolactin releasing factor. J Neuroendocrinol 13: 1-14, 2001


  3. Maruyama W, Akao Y, Youdim MBH, Davis BA, Naoi M: Transfection-enforced Bcl-2 overexpression and an anti-Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol. J Neurochem 78: 727-735, 2001


  4. Maruyama W, Youdim MB, Naoi M: Antiapoptotic proparties of rasagiline, N-propargylamine- 1(R)-aminoindan, and its optical (S)-isomer. TV1022. Ann NY Acad Sci 939: 320-329, 2001


  5. Maruyama W, Kato Y, Yamamoto T, Oh-hashi K, Hashizume Y, Naoi M: Peroxynitrite induces neuronal cell death in aging and age-associated disorders. J Am Aging Assoc 24: 11-18, 2001


  6. Naoi M, Maruyama W, Akao Y, Zhang J, Parvez H: Apoptosis induced by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopamine neurons. Toxicology 153: 123-141, 2001


  7. Oh-hashi K, Maruyama W, Isobe K: Peroxynitrite induces gadd34, 45 and 153 via p38 MAPK in human neuroblastoma SH-SY5Y cells. Free Radic Biol Med 30: 213-221, 2001


  8. Maruyama W, Boulton AA, Davis BA, Dostert P, Naoi M: Enantio-specific induction of apoptosis by an endogenous neurotoxin, N-methyl(R)salsolinol, in dopaminergic SH-SY5Y cells: Suppression of apoptosis by N-(2-heptyl)-N-methylpropargylamine. J Neural Transm 108: 11-24, 2001


OY@K@iwEw@wnȁj
  1. Mochizuki H, Hayakawa H, Migita M, Shibata M, Tanaka R, Suzuki A, Shimo-Nakanishi Y, Urabe T, Yamada M, Tamayose K, Shimada T, Miura M, Mizuno Y: An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as anti-apoptotic gene therapy for Parkinsonfs disease. Proc Natl Acad Sci USA 98: 10918-10923, 2001


  2. Shibata M, Kanamori S, Ohsawa Y, Watanabe T, Yayoi Y, Miura M, Kominami E, Uchiyama Y: Prevention of apoptosis of mammalian cells by the CED-3-cleaved form of CED-9. Arch Histol Cytol 64: 17-28, 2001


  3. Kim KW, Chung HH, Chung CW, Kim IK, Miura M, Wang S, Zhu H, Moon KD, Rha GB, Park JH, Jo DG, Woo HN, Song YH, Kim BJ, Yuan J, Jung YK: Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3FCleavage of the common alpha subunit during apoptosis. Oncogene 20: 358-366, 2001


  4. Hisahara S, Yuan J, Momoi T, Okano H, Miura M: Caspase-11 mediates oligodendrocytes cell death and pathogenesis of autoimmune-mediated demyelination. J Exp Med 193: 111-122, 2001


  5. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, Miura M: Reaper-mediated inhibition of DIAP1-induced Drosophila TRAF1 degradation leads to JNK activation. Nat Cell Biol 4: 705-710, 2002


  6. Takeyama K, Ito S, Yamamoto A, Tanimoto H, Furutani T, Kanuka H, Miura M, Tabata T, Kato S: Androgen-dependent neurodegeneration by polyglutamine-expanded human androgen receptor in Drosophila. Neuron 35: 855-864, 2002


  7. Kanda H, Igaki T, Kanuka H, Yagi T, Miura M: Wengen, a member of the Drosophila TNF receptor superfamily, is required for Eiger signaling. J Biol Chem 277: 28372-28375, 2002


  8. Igaki T, Kanda H, Yamamoto-Goto Y, Kanuka H, Kuranaga E, Aigaki T, Miura M: Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J 21: 3009-3018, 2002


  9. Igaki T, Yamamoto-Goto Y, Tokushige N, Kanda H, Miura M: Downregulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by DARK and DRONC. J Biol Chem 277: 23103-23106, 2002


  10. Shibata M, Yamawaki T, Hattori H, Hamada J, Fukuuchi Y, Okano H, Miura M: Upregulation of Akt phosphorylation at the early stage of middle cerebral artery occlusion in mice. Brain Res 942: 1-10, 2002


  11. Araki T, Hayashi M, Watanabe N, Kanuka H, Yoshino J, Miura M, Saruta T: Down regulation of Mcl-1 by inhibition of the PI3-K/Akt pathway is required for cell shrinkage-dependent cell death. Biochem Biophys Res Commun 290: 1275-1281, 2002


  12. Qiao J, Mitsuhara I, Yazaki Y, Sakano K, Gotoh Y, Miura M, Ohashi Y: Enhanced registance to salt, cold and wound stresses by overproduction of animal cell death suppressors Bcl-xL and Ced-9 in tobacco cells: Their possible contribution through improved function of organella. Plant Cell Physiol 43: 992-1005, 2002


  13. Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R: The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J 22: 6665-6674, 2003


  14. Kanuka H, Kuranaga E, Hiratou T, Igaki T, Nelson B, Okano H, Miura M: Cytosol-ER interplay by Sec61α translocon in polyglutamine-mediated neurotoxicity in Drosophila. Proc Natl Acad Sci USA 100: 11723-11728, 2003


  15. Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila.  Neurosci Lett 336: 155-158, 2003


  16. Takemoto K, Nagai T, Miyawaki A, Miura M: Spatio-temporal activation of caspase revealed by indicator that is insensitive to environmental effects. J Cell Biol 160: 235-243, 2003


  17. Arai H, Furuya T, Yasuda T, Miura M, Mizuno Y, Mochizuki H: Neurotoxic effects of lipopolysaccharide on nigral dopaminergic neurons are mediated by microglial activation, interleukin-1β and expression of caspase-11 in mice. J Biol Chem 279: 51647-51653, 2004


  18. Kakinuma Y, Saitoh F, Osawa S, Miura M: A mechanism of impaired mobility of oligodendrocyte progenitor cells by tenascin C through modification of Wnt signaling. FEBS Lett 568: 60-64, 2004


  19. Kakinuma Y, Saitoh F, Ohsawa S, Furuichi T, Miura M: A sulfatase regulating the migratory potency of oligodendrocyte progenitor cells through tyrosine phosphorylation of β-catenin. J Neurosci Res 77: 653-661, 2004


  20. Furuya T, Hayakawa H, Yamada M, Yoshimi K, Hisahara S, Miura M, Mizuno Y, Mochizuki H: Caspase-11 mediates inflammatory dopaminergic cell death in the 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine mouse model of Parkinson's disease. J Neurosci 24: 1865-1872, 2004


  21. Iwawaki T, Akai R, Kohno K, Miura M: A transgenic mouse model for monitoring endoplasmic reticulum stress. Nat Med 10: 98-102, 2004


  22. Ohsawa S, Hamada S, Kakinuma Y, Yagi T, Miura M: A novel function of neuronal PAS domain protein 1 (NPAS1) in erythropoietin expression in neuronal cells. J Neurosci Res 79: 451-458, 2005


  23. Kanuka H, Hiratou T, Igaki T, Kanda H, Kuranaga E, Sawamoto K, Aigaki T, Miura M: Gain-of-function screen identifies a role of the Sec61α translocon in Drosophila postmitotic neurotoxicity. Biochim Biophys Acta in press


  24. Senoo-Matsuda N, Igaki T, Miura M: Bax-like protein Drob-1 protects neurons from expanded polyglutamine-induced toxicity in Drosophila.EMBO J 24: 2700-2713, 2005


  25. Tamura M, Nakamura M, Ogawa Y, Toyama Y, Miura M, Okano H: Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury. Glia 51: 312-321, 2005


  26. Nelson B, Nishimura S, Kanuka H, Kuranaga E, Inoue M, Hori G, Nakahara H, Miura M: Isolation of gene sets affected specifically by polyglutamine expression: implication of the TOR signaling pathway in neurodegeneraton. Cell Death Differ 12: 1115-1123, 2005


V@pm@iȎȑwEw@㎕wȁj
  1. Mitoma H, Song SY, Ishida K, Yamakuni T, Kobayashi T, Mizusawa H: Presynapic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J Neurol Sci 175: 40-44, 2000


  2. Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T: Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function.J Biol Chem275: 10893-10898, 2000


  3. Yang Q, Hashizume Y, Yoshida M, Wang Y, Goto Y, Mitsuma N, Ishikawa K, Mizusawa H: Morphological Purkinje cell changes in spinocerebellar ataxia type 6. Acta Neuropathol 100: 371-376, 2000


  4. Yokota T, Uchihara T, Kumagai J, Shiojiri T, Pang JJ, Arita M, Arai H, Hayashi M, Kiyosawa M, Okeda R, Mizusawa H: Postmortem study of ataxia with retinitis pigmentosa by mutation of the α-tocopherol transfer protein. J Neurol Neurosurg Psychiat 68: 521-525, 2000


  5. Kanda T, Iwasaki T, Yamawaki M, Tai T, Mizasawa H: Anti-GM-1 antibody facilitates leakage in an in vitro blood-nerve barrier model. Neurology 55: 585-587, 2000


  6. Orimo S, Ozawa E, Uematsu M, Yoshida E, Hino H, Yamada M, Okeda R, Mizusawa H: A case of Creutzfeldt-Jakob disease presenting with auditory agnosia as an initial manifestation. Eur Neurol 44: 256-258, 2000


  7. Sasaki J, Ishikawa K, Kobayashi K, Kondo IE, Fukayama M, Mizusawa H, Takashima S, Sakakihara Y, Nakamura Y, Toda T: Neural expression of the fukutin gene. Hum Mol Genet 9: 3083-3090, 2000


  8. Nagaoka U, Takashima M, Ishikawa K, Yoshizawa K, Yoshizawa T, Ishikawa M, Yamawaki T, Shoji S, Mizusawa H: A gene on SCA4 locus causes dominantly inherited pure cerebellar ataxia. Neurology 54: 1971-1975, 2000


  9. Fujigasaki H, Uchihara T, Koyano S, Iwabuchi K, Yagishita S, Makifuchi T, Nakamura A, Ishida K, Toru S, Hirai S, Ishikawa K, Tanabe T, Mizusawa H: Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains. Exp Neurol 165: 248-256, 2000


  10. Kanda T, Iwasaki T, Nakamura S, Kurokawa T, Ikeda K, Mizusawa H: Self-secretion of fibroblast growth factor-9 supports basal forebrain cholinergic neurons in an autocrine/paracrine manner. Brain Res 876: 22-30, 2000


  11. Yaginuma M, Ishida K, Uchihara T, Suzuki F, Aoki M, Tanaka T, Murase H, Ikeda K, Mizusawa H: Paraneoplastic cerebellar ataxia with mild cerebello-olivary degeneration and an anti-neuronal antibody: a clinicopathological study. Neuropathol Appl Neurobiol 26: 568-572, 2000


  12. Takashima M, Ishikawa K, Nagaoka U, Shoji S, Mizusawa H: A linkage disequilibrium at the candidate gene locus for 16q-linked autosomal dominant cerebellar ataxia type III in Japan. J Hum Genet 46: 167-171, 2001


  13. Ishikawa K, Owada K, Ishida K, Fujigasaki H, Shun LM, Tsunemi T, Ohkoshi N, Toru S, Mizutani T, Hayashi M, Arai N, Hasegawa K, Kawanami T, Kato T, Makifuchi T, Shoji S, Tanabe T, Mizusawa H: Cytoplasmic and nuclear polyglutamine aggregates in SCA6 Purkinje cells. Neurology 56: 1753-1756, 2001


  14. Takenoshita H, Shizuka IM, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K: Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiat 70: 386-389, 2001


  15. Fujigasaki H, Uchihara T, Takahashi J, Matsushita H, Nakamura A, Koyano S, Iwabuchi K, Hirai S, Mizusawa H: Preferential recruitment of ataxin-3 independent of expanded polyglutamine: an immunohistochemical study on Marinesco bodies. J Neurol Neurosurg Psychiat 71: 518-520, 2001


  16. Yokota T, Igarashi K, Uchihara T, Jishage K, Tomita H, Inaba A, Li Y, Arita M, Suzuki H , Mizusawa H, Arai H: Delayed-onset ataxia in mice lacking a-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress. Proc Natl Acad Sci USA 98: 15185-15190, 2001


  17. Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T: Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. J Biol Chem 277: 7214-7221, 2002


  18. Miake H, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of α synuclein filaments. J Biol Chem 277: 19213-19219, 2002


  19. Ohara S, Iwahashi T, Oide T, Hayashi R, Nakajima T, Ishikawa K, Mizusawa H: Spinocerebellar ataxia type6 with motor neuron loss: A follow-up autopsy report. J Neurol 294: 633-635, 2002


  20. Owada K, Uchihara T, Ishida K, Mizusawa H, Watabiki S, Tsuchiya K: Motor weakness and cerebellar ataxa in Sjogren syndrome- identification of antineuronal antibody: a case report. J Neurol Sci 197: 79-84, 2002


  21. Kubodera T, Yokota T, Ohwada K, Ishikawa K, Miura H, Matsuoka T, Mizusawa H: Proteolytic cleavage and cellular toxicity of the human α1A calcium channel in spinocerebellar ataxia type 6 (SCA6). Neurosci Lett 341: 74-78, 2003


  22. Li M, Ishikawa K, Toru S, Tomimitsu H, Takashima M, Goto J, Takiyama Y, Sasaki H, Imoto I, Imazawa J, Toda T, Kanazawa I, Mizusawa H: Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ACDA) type III in Japan. J Hum Genet 48: 111-118, 2003


  23. Mitoma H, Ishida K, Ikeda M, Mizusawa H: Dual impariment of GABAA- and GABAB-receptor-mediated synaptic responses by autoantibodies to glutamic acidic decarboxylase. J Neurol Sci 208: 51-56, 2003


  24. Yokota T, Sugawara K, Ito K, Takahashi R, Ariga H, Mizusawa H: Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem Biophys Res Commun 312: 1342-1348, 2003


  25. Takahashi H, Ishikawa K, Tsutsumi T, Fujigasaki H, Kawata A, Okiyama R, Fujita T, Yoshizawa K, Yamaguchi S, Tomiyasu H, Yoshii F, Mitani K, Shimizu N, Yamazaki M, Miyamoto T, Orimo T, Shoji S, Kitamura K, Mizusawa H: A clinical and genetic study in a large cohort of patients with spinocerebellar ataxia type 6. J Hum Genet 49: 256-264, 2004


  26. Li Y, Yokota T, Matsumura R, Taira K, Mizusawa H: Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA. Ann Neurol 56: 124-129, 2004


{c@Y@i{ȑwEwj
  1. Ui-Tei K, Nagano M, Sato S, Miyata Y: Calmodulin-dependent and -independent apoptosis in cells of a Drosophila neuronal cell line. Apoptosis 5: 133-140, 2000


  2. Ui-Tei K, Zenno S, Miyata Y, Saigo K: Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target. FEBS Lett 479: 79-82, 2000


  3. Hamada T, Ui-Tei K, Miyata Y: A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. FEBS Lett 475: 97-102, 2000


  4. Hamada T, Ui-Tei K, Imaki J, Miyata Y: Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/ fallotein. Biochem Biophys Res Commun 280: 733-737, 2001


  5. Nagano M, Ui-Tei K, Suzuki H, Piao ZF, Miyata Y: CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells. Apoptosis 5: 543-550, 2000


{@@ikwEw@wnȁj
  1. Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, Kitamoto N, Itohara S, Kasai N, Katsuki M, Higuchi J, Muramoto T, Shin R-W: Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem Biophys Res Commun 294: 280-286, 2002


X@@iwEw@wnȁj
  1. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T: NF-kappaB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. NeuroReport 12: 2079-2084, 2001


  2. Hayashi K, Morishita R, Nakagami H, Yoshimura S, Hara A, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T, Sakai N: Gene therapy for preventing neuronal death using hepatocyte growth factor: in vivo gene transfer of HGF to subarachnoid space prevents delayed neuronal death in gerbil hippocampal CA1 neurons. Gene Ther 8: 1167-1173, 2001


  3. Sakaue G, Shimaoka M, Fukuoka T, Hiroi T, Inoue T, Hashimoto N, Sakaguchi T, Sawa Y, Morishita R, Kiyono H, Noguchi K, Mashimo T: NF-kappa B decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. NeuroReport 12: 2079-2084, 2001


  4. Inoue T, Sawa Y, Kitagawa-Sakakida S, Nishimura M, Morishita R, Kaneda Y, Kohmura E, Yoshimine T, Matsuda H: Nuclear factor-kappaB decoy attenuates neuronal damage after global brain ischemia: A future strategy for brain protection during circulatory arrest. J Thorac Cardiovasc Surg 122: 720-727, 2001


  5. Yoshimura S, Morishita R, Hayashi K, Yamamoto K, Nakagami H, Kaneda Y, Sakai N, Ogihara T: Inhibition of intimal hyperplasia after balloon injury in rat carotid artery model using cis-element "decoy" of nuclear factor-kB binding site as a novel molecular strategy. Gene Ther 8: 1635-1642, 2001


  6. Taniyama Y, Tachibana K, Hiraoka K, Namba T, Yamasaki K, Hashiya N, Aoki M, Ogihara T, Kaneda Y, Morishita R: Local delivery of plasmid DNA into rat carotid artery using ultrasound. Circulation 105: 1233-1239, 2002


  7. Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y: N1411 mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci 70: 2567-2580, 2002


  8. Yoshimura S, Morishita R, Hayashi K, Kokuzawa J, Aoki M, Matsumoto K, Nakamura T, Ogihara T, Kaneda Y, Sakai N: Gene transfer of hepatocyte growth factor to subarachnoid space in cerebral hypoperfusion model. Hypertension 39: 1028-1034, 2002


  9. Shimamura M, Morishita R, Endoh M, Oshima K, Aoki M, Waguri S, Uchiyama Y, Kaneda Y: HVJ-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun 300: 464-471, 2003


V@@iLOlaj
  1. Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294: 429-440, 2002


  2. Yazawa I, Hazeki N, Nakase H, Kanazawa I, Tanaka M: Histone H3 is aberrantly phosphorylated in glutamine-repeat diseases. Biochem Biophys Res Commun 302: 144-149, 2003


@@i_ˑwEw@wnȁj
  1. Takahashi S, Inatome R, Hotta A, Qin Q, Hackenmiller R, Simon M.C, Yamamura H, Yanagi S: Role for Fes/Fps tyrosine kinase in microtubule nucleation through its FCH domain. J Biol Chem 278: 49129-49133, 2003


  2. Hirose M, Kitano J, Nakajima Y, Moriyoshi K, Yanagi S, Yamamura H, Muto T, Jingami H, Nakanishi S: Phosphorylation and recruitment of Syk by ITAM-based phosphorylation of tamalin. J Biol Chem 279: 32308-32315, 2004


  3. Hotta A, Inatome R, Yuasa-Kawada J, Qin Q, Yamamura H, Yanagi S: Critical role of CRMP-associated molecule CRAM for filopodia and growth cone development in neurons. Mol Biol Cell 16: 32-39, 2005


R@rG@itwEw@wȁj
  1. Hasegawa Y, Fujitani M, Hata K, Tohyama M, Yamagishi S, Yamashita T: Promotion of axon regeneration by MAG and Nogo through divergent signals downstream of Gi/G. J Neurosci 24: 6826-6832, 2004


  2. Madura T, Yamashita T, Kubo T, Fujitani M, Hosokawa K, Tohyama M: Activation of Rho in the injured axons following spinal cord injury. EMBO Rep 5: 412-417, 2004


  3. Aoki M, Yamashita T, Tohyama M: EphA receptors direct the differentiation of mammalian neural precursor cells through Ras/MAPK pathway. Chem J Biol 279: 32643-32650, 2004


  4. Fujitani M, Yamagishi S, Che Y-H, Hata K, Kubo T, Ino H, Tohyama M, Yamashita T: P311 accelerates nerve regeneration of the axotomized facial nerve. J Neurochem 91: 737-744, 2004


  5. Mizuno T, Yamashita T, Tohyama M: Chimaerins act downstream from neurotrophins in overcoming inhibition of neurite outgrowth by MAG. J Neurochem 91: 395-403, 2004


  6. Tanaka H, Yamashita T, Yachi K, Fujiwara K, Yoshikawa K, Tohyama M: Cytoplasmic p21Cip1/WAF1 enhances axonal regeneration and functional recovery after spinal cord injury in rats. Neuroscience 127: 155-164, 2004


  7. Tsuji L, Yamashita T, Kubo T, Madura T, Tanaka H, Hosokawa K, Tohyama M: A cell surface molecule containing LRR repeats and a FNIII domain, FLRT3, promotes neurite outgrowth. Biochem Biophys Res Commun 313: 1086-1091, 2004


  8. Madura T, Yamashita T, Tsuji L, Hosokawa K, Tohyama M: Changes in mRNA of Slit-Robo GTPase activating protein 2 following facial nerve transection. Mol Brain Res 123: 76-80, 2004


  9. Yamagishi S, Fujitani M, Hata K, Kitajo K, Mimura F, Abe H, Yamashita T: Wallerian degeneration involves Rho/Rho-kinase signaling. J Biol Chem 280: 20384-20388, 2005


  10. Fujitani M, Kawai H,Proia RL, Kashiwagi A, Yasuda H, Yamashita T: Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction. J Neurochem 94: 15-21, 2005


  11. Fujitani M, Honda A, Hata K, Yamagishi S, Tohyama M, Yamashita T: Biological activity of neurotrophins is dependent on recruitment of Rac1 to lipid rafts. Biochem Biophys Res Commun 327: 150-154, 2005


  12. Yamashita T, Fujitani M, Yamagishi S, Hata K, Mimura F: Multiple signals regulate axon regeneration through the Nogo receptor complex. Mol Neurobiol 32: 105-112, 2005


  13. Yamashita T, Fujitani M, Hata K, Mimura F, Yamagishi S: Diverse functions of the p75 neurotrophin receptor. Anat Sci Int 80: 37-41, 2005


  14. Doya H, Ohtori S, Takahashi K, Aoki Y, Ino H, Takahashi Y, Moriya H, Yamashita T: ERK MAP kinase activation in the dorsal root ganglion (DRG) and the spinal cord following DRG injury in rats. Spine 30: 2252-2256, 2005


R@j@iLwEwERȁj
  1. Nakamura T, Yamashita H, Takahashi T, Nakamura S: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. Biochem Biophys Res Commun 280: 1085-1092, 2001


  2. Nagano Y, Yamashita H, Nakamura T, Takahashi T, Kondo E, Nakamura S: Lack of binding observed between human alpha-synuclein and Bcl-2 protein family. Neurosci Lett 316: 103-107, 2001


  3. Nakamura S, Takahashi T, Yamashita H, Kawakami H: Nicotinic acetylcholine receptors and neurodegenerative disease. Alcohol 24: 79-81, 2001


  4. Nakamura T, Yamashita H, Nagano Y, Takahashi T, Avraham S, Avraham H, Matsumoto M, Nakamura S: Activation of Pyk2/RAFTK induces tyrosine phosphorylation of alpha-synuclein via Src-family kinases. FEBS Lett 521: 190-194, 2002


  5. Takahashi T, Yamashita H, Nakamura T, Nagano Y, Nakamura S: Tyrosine 125 of alpha -synuclein plays a critical role for dimerization following nitrative stress. Brain Res 938: 73-80, 2002


Rc@@iVwE]j
  1. Yamada M, Tan C-F, Inenaga C, Tsuji S, Takahashi H: Sharing of polyglutamine localization by the neuronal nucleus and cytoplasm in CAG-repeat diseases. Neuropathol Appl Neurobiol 30: 665-675, 2004


  2. Toyoshima Y, Yamada M, Onodera O, Shimohata M, Inenaga C, Fujita N, Morita M, Tsuji S, Takahashi H: SCA17 homozygote showing Huntingtonfs disease-like phenotype. Ann Neurol 55: 281-286, 2004


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  1. Yoshizawa T, Yoshida H, Shoji S: Differential susceptibility of cultured cell lines to aggregate formation and cell death produced by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Brain Res Bull 56: 349-352, 2001


  2. Ohye T, Ichinose H, Yoshizawa T, Kanazawa I, Nagatsu T: A new splicing variant for human tyrosine hydroxylase in the adrenal medulla. Neurosci Lett 312: 157-160, 2001 Hatakeyama S, Wakamori M, Ino M, Miyamoto N, Takahashi E, Yoshinaga T, Sawada K, Imoto K, Tanaka I, Yoshizawa T, Nishizawa Y, Mori Y, Niidome T, Shoji S: Differential nociceptive responses in mice lacking the alpha 1B subunit of N-type Ca2+ channels. NeuroReport 118: 2423-2427, 2001


  3. Yoshizawa T, Kohno Y, Nissato S, Shoji S: Compound heterozygosity with 2 novel mutations in the HEXB gene produces adult Sandhoff disease presenting as a motor neuron disease phenotype. J Neurol Sci 195: 129-138, 2002


  4. Nakayama J, Yoshizawa T, Yamamoto N, Arinami T: Mutation analysis of the calpastatin gene (CAST) in patients with Alzheimer's disease. Neurosci Lett 320: 77-80, 2002


  5. Yoshida H, Yoshizawa T, Shibasaki F, Shoji S, Kanazawa I: Chemical chaperones reduce aggregate formation and cell death caused by the truncated Machado-Joseph disease gene product with an expanded polyglutamine stretch. Neurobiol Dis 10: 88-99, 2002


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  1. Haraguchi M, Torii S, Matsuzawa S, Xie Z, Kitada S, Krajewski S, Yoshida H, Mak TW, Reed JC: Apoptotic protease activating factor 1 (Apaf-1)-independent cell death suppression by Bcl-2. J Exp Med 191: 1709-1720, 2000


  2. Guo Z, Yikang S, Yoshida H, Mak TW, Zacksenhaus E: Inactivation of the retinoblastoma tumor suppressor induces apoptosis protease-activating factor-1 dependent and independent apoptotic pathways during embryogenesis. Cancer Res 61: 8395-8400, 2001


  3. Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, Yoshida H, Liu D, Elledge SJ, Mak TW: DNA damage-Induced activation of p53 by the checkpoint kinase Chk2. Science 287: 1824-1827, 2000


  4. Joza N, Susin SA, Daugas E, Stanford WL, Cho SK, Li CY, Sasaki T, Elia AJ, Cheng HY, Ravagnan L, Ferri KF, Zamzami N, Wakeham A, Hakem R, Yoshida H, Kong YY, Mak TW, Zuniga-Pflucker JC, Kroemer G, Penninger JM: Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature 410: 549-554, 2001


  5. Miyazaki K, Yoshida H, Sasaki M, Hara H, Kimura G, Mak TW, Nomoto K: Caspase-independent cell death and mitochondrial disruptions observed in the apaf1-deficient cells. J Biochem 129: 963-969, 2001


  6. Hossain MS, Takimoto H, Ninomiya T, Yoshida H, Kishihara K, Matsuzaki G, Kimura G, Nomoto K: Characterization of CD4- CD8- CD3+ T-cell receptor-alphabeta+ T cells in murine cytomegalovirus infection. Immunology 101: 19-29, 2000


  7. Ninomiya T, Takimoto H, Matsuzaki G, Hamano S, Yoshida H, Yoshikai Y, Kimura G, Nomoto K: Vgamma1+ gammadelta T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-gamma. Immunology 99: 187-194, 2000


  8. Yada S, Nukina H, Kishihara K, Takamura N, Yoshida H, Inagaki-Ohara K, Nomoto K, Lin T: IL-7 prevents both caspase-dependent and -independent pathways that lead to the spontaneous apoptosis of i-IEL. Cell Immunol 208: 88-95, 2001


  9. Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, Mu S, Xia M, Wakeham AC, Nishina H, Potter J, Saris CJ, Mak TW: WSX-1 is required for the initiation of Th1 responses and resistance to L. major Infection. Immunity 15: 569-578, 2001


  10. Ferry S, Matsuda M, Yoshida H, Hirata M: Inositol hexakisphosphate blocks tumor cell growth by activating apoptotic machinery as well as by inhibiting the Akt/NFkappaB-mediated cell survival pathway. Carcinogenesis 23: 2031-2041, 2002


  11. Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H: The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes. J Immunol 168: 2288-2295, 2002


  12. Haraguchi M, Tsujimoto H, Fukushima M, Higuchi I, Kuribayashi H, Utsumi H, Nakayama A, Hashizume Y, Hirato J, Yoshida H, Hara H, Hamano S, Kawaguchi H, Furukawa T, Miyazono K, Ishikawa F, Toyoshima H, Kaname T, Komatsu M, Chen ZS, Gotanda T, Tachiwada T, Sumizawa T, Miyadera K, Osame M, Noda T, Yamada Y, Akiyama S: Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol Cell Biol 22: 5212-5221, 2002


  13. Inagaki-Ohara K, Takamura N, Yada S, Alnadjim Z, Liu E, Yu X, Yoshida H, Lin T: Radiation-induced crypt intestinal epithelial cell apoptosis in vivo involves both caspase-3-dependent and -independent pathways. Dig Dis Sci 47: 2823-2830, 2002


  14. Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A: SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17: 583-91, 2002


  15. Sasaki M, Miyazaki K, Koga Y, Kimura G, Nomoto K, Yoshida H: Calcineurin-dependent mitochondrial disturbances in calcium-induced apoptosis of human immunodeficiency virus gp160-expressing CD4+ cells. J Virol 76: 416-420, 2002


  16. Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J, Wagner EF, Mak TW, Kodama T, Taniguchi T: Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3: 889-901, 2002


  17. Yoshida H, Okada Y, Kinoshita N, Hara H, Sasaki M, Sawa H, Nagashima K, Mak TW, Ikeda K, Motoyama N: Differential requirement for Apaf1 and Bcl-X(L) in the regulation of programmed cell death during development. Cell Death Differ 9: 1273-1276, 2002


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  1. Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M: Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet 27: 369-370, 2001


  2. Yamada Y, Miura K, Kumagai T, Hayakawa C, Miyazaki S, Matsumoto A, Kurosawa K, Nomura N, Taniguchi H, Sonta S, Yamanaka T, Wakamatsu N: Molecular analysis of Japanese patients with Rett syndrome: Identification of five novel mutations and genotype-phenotype correlation. Hum Mutat 18: 253, 2001


  3. Yamada K, Yamada Y, Nomura N, Miura K, Wakako R, Hayakawa C, Matsumoto A, Kumagai T, Yoshimura I, Miyazaki S, Kato K, Sonta S, Ono H, Yamanaka T, Nagaya M, Wakamatsu N: Nonsense and frameshift mutations in ZFHX1B, encoding Smad-Interacting protein 1, cause a complex developmental disorder with a great variety of clinical features. Am J Hum Genet 69: 1178-1185, 2001


  4. Nagaya M, Kato J, Niimi, N, Tanaka S, Wakamatsu N: Clinical feature of a form of Hirschsprungfs disease caused by a novel genetic abnormality. J Pediar Surg 37: 1117-1122, 2002


  5. Yoneda M, Fujita T, Yamada Y, Yamada K, Fujii A, Inagaki T, Nakagawa H, Kishikawa M, Shimada A, Nagaya M, Azuma T, Kuriyama M, Wakamatsu N: Late infantile Hirschsprung disease-mental retardation syndrome with a 3-bp deletion in ZFHX1B. Neurology 59: 1637-1640, 2002



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