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  1. Misonou H, Morishima-Kawashima M, Ihara Y: Oxidative stress induces intracellular accumulation of amyloid β-protein (Aβ) in human neuroblastoma cells. Biochemistry 39: 6951-6959, 2000


  2. Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S: Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course, J Neurol Sci 177: 48-59, 2000


  3. Gu Y, Hamajima N, Ihara Y: Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518 and Ser-522. Biochemistry 39: 4267-4275, 2000


  4. Gu Y, Ihara Y: Evidence that collapsin response mediator protein-2 (CRMP-2) is involved in the dynamics of microtubules. J Biol Chem 275: 17917-17920, 2000


  5. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Ito M, Oyama F, Ando S, Ihara Y: Mutant-presenilin 2-transgenic mice: A large increase in the levels of Aβ42 is presumably associated with the low-density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem 275: 27901-27908, 2000


  6. Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, lhara Y: Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain. Am J Pathol 157: 2093-2099, 2000


  7. Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y: Molecular analysis of mutant and wild-type tau deposited in the brain affected by FTDP-17 R406W mutation. Am J Pathol 158: 373-379, 2001


  8. Yamazaki T, Chang TY, Haass C, Ihara Y: Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-Pick Type C cells. J Biol Chem 276: 4454-4460, 2001


  9. Yamaguchi H, Sugihara S, Ogawa A, Ihara Y: Alzheimer β amyloid deposition, which is hastened by ApoE ε4 gene, precedes neurofibrillary pathology in the frontal association cortex of non-demented senior subjects. J Neuropathol Exp Neurol 60: 731-739, 2001


  10. Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y: Accumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brain. Am J Pathol 158: 2209-2218, 2001


  11. Miyasaka T, Morishima-Kawashima M, Ravid R, Kamphorst W, Nagashima K, Ihara Y: Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation. J Neuropathol Exp Neurol 60: 872-884, 2001


  12. Gu Y, Misonou H, Sato T, Dohmae N, Takio K, IharaY: Distinct intramembrane cleavage of the β-amyloid precursor protein family resembling γ-secretase-like cleavage of Notch. J Biol Chem 276: 35235-35238, 2001


  13. Utsunomiya I, Ren J, Taguchi K, Ariga T, Tai T, Ihara Y, Miyatake T: Immunohistochemical detection of verotoxin receptors in nervous system. Brain Res Protoc 8: 99-103, 2001


  14. Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH: Collapsin response mediator protein-2 inhibits neuronal phospholipase D2 activity by direct interaction. J Biol Chem 277: 6542-6549, 2002


  15. Qi Y, Morishima-Kawashima M, Sato T,Mitsumori R, lhara Y: Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid β-protein 42 in Chinese hamster ovary cells. Biochemistry 42: 1042-1052, 2003


  16. Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y: Potential link between amyloid β-protein 42 and C-terminal fragment γ49-99 of β-amyloid precursor protein. J Biol Chem 278: 24294-24301, 2003


  17. Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S: Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 22: 2913-2923, 2003


  18. WadaS, Morishima-KawashimaM, QiY, MisonoH, ShimadaY, Ohno-IwashitaY, Ihara Y: γ-Secretase activity is present in rafts, but not cholesterol-dependent. Biochemistry 42: 13977-13986, 2003


  19. Watanabe N, Araki W, Chui DH, Makifuchi T, Ihara Y, Tabira T: Glypican-1 as an Aβ binding HSPG in the human brain: Its localization in DIG domains and possible roles in the pathogenesis of Alzheimer's disease. FASEB J 18: 1013-1015, 2004


  20. Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, NukinaN, Ihara Y: Gem GTPase and tau: morphological changes induced by Gem GTPase in CHO cells are antagonized by tau. J Biol Chem 279: 27272-27277, 2004


  21. Watanabe A, Hong W-K, Dohmae N, Takio K, Morishima-Kawashima M, Ihara Y: Molecular aging of tau: disulfide-independent aggregation and nonenzymatic degradation in vitro and in vivo. J Neurochem 90: 1302-1311, 2004


  22. FunamotoS, Morishima-KawashimaM, TanimuraY, HirotaniN, SaidoTC, IharaY: Truncated carboxyl terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42. Biochemistry 43: 13532-13540, 2004


  23. Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Hirotani N, Horikoshi Y, Maeda M, Saido TC, Ihara Y: Longer forms of amyloid β-protein: implications for the mechanism of intramembranous cleavage by γ-secretase. J Neurosci 25: 436-445, 2005


  24. Uchida Y, Ohshima T, Sasaki Y, Suzuki H, Yanai S, Yamashita N, Nakamura F, Takei K, Ihara Y, Mikoshiba K, Kolattukudy P, Honnorat J, Goshima Y: Semaphorin3A signalling is mediated via sequential Cdk5 and GSK3beta phosphorylation of CRMP2: implication of common phosphorylating mechanism underlying axon guidance and Alzheimer's disease. Genes Cells 10: 165-179, 2005


  25. Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y: Independent accumulations of tau and amyloidâ-protein in the human entorhinal cortex. Neurology 64: 687-692, 2005


  26. Miyasaka T, Ding Z, Gengyo-Ando K, Oue M, Yamaguchi H, Mitani S, Ihara Y: Progressive neurodegeneration in C. elegans model of tauopathy. Neurobiol Dis 20:372-383,2005


  27. Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M: Random mutagenesis of presenilin 1 identifies novel mutants exclusively generating long amyloid beta peptides. J Biol Chem 280: 19070-19077, 2005


  28. Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawasdhima M, Ihara Y: Blocking the cleavage at midportion between γ- and ε-sites remarkably suppresses the generation of amyloid β-protein. FEBS Lett 579: 2907-2912, 2005


  29. Miyasaka T, Watanabe A, Saito Y, Murayama S, Mann DMA, Yamazaki M, Ravid R, Morishima-Kawashima M, Nagashima K, Ihara Y: Visualization of newly deposited tau in neurofibrillary tangles and neuropil threads. J Neuropathol Exp Neurol 64: 665-674, 2005


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  1. Tanahashi H, Tabira T: Two RFLPs (AciI; c954C/T and FokI c1023T/C) within the coding region of the gene for human Fe65L2 inter-acting with Alzheimerfs beta-amyloid precursor protein. Hum Mutat 15: 121, 2000


  2. Shirotani K, Takahashi K, Araki W, Tabira T: Mutational analysis of intrinsic regions of presenilin 2 which determine its endoproteolytic cleavage and pathological function. J Biol Chem 275: 3681-3686, 2000


  3. Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T: Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci 20: 1568-1574, 2000


  4. Tanahashi H, Tabira T: Alkaline treatment after X-gal staining reaction for Escherichia coli β-galactosidase enhances sensitivity. Anal Biochem 279: 122-123, 2000


  5. Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Goedert M, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology 54: 1787-95, 2000


  6. Kodama K, Okada S, Iseki E, Kowalska A, Tabira T, Hosoi N, Yamanouchi N, Noda S, Komatsu N, Nakazato M, Kumakiri C, Yazaki M, Sato T: Familial frontotemporal dementia with a P301L tau mutation in Japan. J Neurol Sci 176: 57-64, 2000


  7. Tanahashi H, Tabira T: Alzheimerfs disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. Hum Mol Genet 9: 2281-2289, 2000


  8. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y: Mutant presenilin 2 transgenic mice. A large increase in the levels of abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem 275: 27901-27908, 2000


  9. Poorkaj P, Grossman M, Steinbart E, Payami H, Sadovnick A, Nochlin D, Tabira T, Trojanowski JQ, Borson S, Galasko D, Reich S, Quinn B, Schellenberg G, Bird TD: Frequency of tau gene mutations in familial and sporadic cases of non-Alzheimer dementia. Arch Neurol 58: 383-387, 2001


  10. Chui DH, Dobo E, Makifuchi T, Akiyama H, Kawakatsu S, Checler F, Araki W, Takahashi K, Tabira T: Apoptotoc neurons in Alzheimerfs disease frequently show intracellular Aβ42 labeling. J Alz Dis 3: 231-239, 2001


  11. Kowalska A, Asada T, Arima K, Kumakiri C, Kozubski W, Takahashi K, Tabira T: Genetic analysis in patients with familial and sporadic frontotemporal dementia: Two tau mutations in only familial cases and no association with apolipoprotein ε4. Dement Geriatr Cogn Disord 12: 387-392, 2001


  12. Ohnishi T, Matsuda H, Tabira T, Kogure D, Kunihiro T, Uema T, Nishikawa M, Kitayama N, Asada T, Uno M: Changes in brain morphology in Alzheimer disease and normal aging: is Alzheimer disease an exaggerated aging process? Am J Neuroradiol 22: 1680-1685, 2001


  13. Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A: Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10 +11-splice site in the tau gene. Ann Neurol 50: 117-120, 2001


  14. Tabira T: Clioquinolfs return: cautions from Japan. (letter to the editor) Science 292: 2251, 2001


  15. Tanahashi H, Tabira T: Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production. Neurosci Lett 307: 9-12, 2001


  16. Mann DMA, et al & Familial Alzheimerfs Disease Study Group (Arango J, Bird T, Van Broeckhoven C, Brooks W, Brown R, Cairns N, Cras P, Ellison D, Haltia M, Li K, Jorgensen A, Krill J, Lantos P, Lippa C, Martins R, Nochlin D, Pollen D, Rosenberg C, Rossor M, Tabira T): Amyloid angiopathy and variability in amyloid beta deposition is determined by mutation position in presenilin-1-linked Alzheimerfs disease. Am J Pathol 158: 2165-2175, 2001


  17. Araki W, Yuasa K, Takeda S, Takeda K, Shirotani K, Takahashi K, Tabira T: Proapoptotic effect of presenilin 2 (PS2) overexpression is associated with down-regulation of Bcl-2 in cultured neurons. J Neurochem 79: 1161-1168, 2001


  18. Tabira T, Chui DH, Kuroda S: Significance of intracellular Abeta42 accumulation in Alzheimerfs disease. Front Biosci 7: a44-9, 2002


  19. Tanahashi H, Asada T, Tabira T: c954C>T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimerfs disease. Ann Neurol 52: 691-693, 2002


  20. Tanahashi H, Tabira T: Characterization of an amyloid precursor protein (APP)-binding protein Fe65L2 and its two novel isoforms lacking phosphotyrosine interaction domain. Biochem J 367: 687-695, 2002


  21. Tabira T, Chui DH, Nakayama H, Kuroda S, Shibuya M: Alzheimer's disease with spastic paresis and cotton wool type plaques. J Neurosci Res 70: 367-372, 2002


  22. Konagaya M, Kato T, Sakai M, Kuru S, Matsuoka Y, Konagaya Y, Hashizume Y, Tabira T: A clinical and pathological study of a Japanese case of amyotrophic lateral sclerosis/Parkinsonism-dementia complex with family history. J Neurol 250: 164-170, 2003


  23. Santa Y, Uyama E, Chui DH, Arima M, Kotorii S, Takahashi K, Tabira T: Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis. J Neurol Sci 212: 79-84, 2003


  24. Watanabe Y, Tsujimura A, Tabira T, Hashimoto-Gotoh T: Differential expression of presenilin- α and -β (PS α and PS β) in Xenopus laevis: embryonic phosphorylation of PSa. Gene 314: 165-172, 2003


  25. Hashimoto-Gotoh T, Tsujimura A, Watanabe Y, Iwabe N, Miyata T, Tabira T: A unifying model for functional difference and redundancy of presenilin-1 and -2 in cell apoptosis and differentiation. Gene 323: 115-123, 2003


  26. Tanahashi H, Asada T, Tabira T: Association between tau polymorphism and male early-onset Alzheimerfs disease. NeuroReport 15: 175-180, 2004


  27. Takeda K, Wataru A, Tabira T: Enhanced generation of intracellular Aβ42 amyloid peptide by mutation of presenilins PS1 and PS2. Eur J Neurosci 19: 258-264, 2004


  28. Mizoguchi K, Ishige A, Takeda S, Aburada M, Tabira T: Endogenous glucocorticoids are essential for maintaining prefrontal cortical cognitive function. J Neurosci 24: 5492-5499, 2004


  29. Watanabe N, Araki W, Chui DH, Makibuchi T, Ihara Y, Tabira T: Glypican-1 as an Aβ binding HSPG in the human brain: its localization in DIG domains and possible roles in the pathogenesis of Alzheimerfs disease. FASEB J 18: 1013-1015, 2004


  30. Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T: Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimerfs disease. J Alz Dis 6: 483-488, 2004


  31. Takeda K, Araki W, Akiyama H, Tabira T: Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain. FASEB J 18: 1755-1757, 2004


  32. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira JI, Tabira T: Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. FASEB J 19: 255-257, 2004


  33. Lakshmana MK, Araki W, Tabira T: A novel death-inducing protein, AB-DIP interacts with amyloid beta protein and mediates its neurotoxicity. FASEB J 19: 1362-1364, 2005


V@FiÌZ^[Ej
  1. Michikawa M, Gong JS, Fan QW, Sawamura N, Yanagisawa K: A novel action of Alzheimer's amyloid β-protein (Aβ)F oligomeric Aβ promotes lipid release. J Neurosci 21: 7226-7235, 2001


  2. Kakio A, Nishimoto S, Yanagisawa K, Kozutsumi Y, Matsuzaki K: Cholesterol-dependent formation of GM1 ganglioside-bound amyloid β-protein, an endogenous seed for Alzheimer amyloid. J Biol Chem 276: 24985-24990, 2001


  3. KawamuraY, KikuchiA, TakadaR, TakadaS, SudohS, ShibamotoS, Yanagisawa K, KomanoH: Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of β-catenin phosphorylation. Eur J Biochem 268: 3036-3041, 2001


  4. Fan QW, Yu W, Senda T, Yanagisawa K, Michikawa M: Cholesterol-dependent microtubule stabilization by modulating tau phosphorylation. J Neurochem 76: 391-400, 2001


  5. Sawamura N, Gong JS, Garver WS, Heidenreich RA, Ninomiya H, Ohno K, Yanagisawa K, Michikawa M: Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice. J Biol Chem 276: 10314-10319, 2001


  6. Isobe I, Yanagisawa K, Michikawa M: 3-(4,5-Dimethylthiazol-2-yl)-2,5-dipenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes. J Neurochem 77: 274-280, 2001


  7. Hayashi H, Igbavboa U, Hamanaka H, Kobayashi M, Fujita SC, Wood WG, Yanagisawa K: Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice. NeuroReport 13: 383-386, 2002


  8. Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M: Apolipoprotein E (apoE) isoform-dependent lipid release from astrocytes prepared from human-apoE3- and apoE4-knock-in mice. J Biol Chem 277: 29919-29926, 2002


  9. Fan QW, Yu W, Gong JS, Zou K, Sawamura N, Senda T, Yanagisawa K, Michikawa M: Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. J Neurochem 80: 178-190, 2002


  10. Zou K, Gong JS, Yanagisawa K, Michikawa M: A Novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci 22: 4833-4841, 2002


  11. Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M: Amyloid β-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade. J Neurosci Res 70: 438-446, 2002


  12. Komano H, Shiraishi H, Kawamura Y, Sai X, Suzuki R, Serneels L, Kawaichi M, Kitamura T, Yanagisawa K: A new functional screening system for identification of regulators for the generation of amyloid β-protein. J Biol Chem 277: 39627-39633, 2002


  13. Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stess-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem 277: 12915-12920, 2002


  14. Kakio A, Nishimoto S, Yanagisawa K, Kozutsumi Y, Matsuzaki K: Interactions of amyloid β-protein with various gangliosides in raft like membranes: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 23: 7385-7390, 2002


  15. Watarai M, Makino S, Michikawa M, Yanagaisawa K, Murakami S, Shirahata T: Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice. Infect Immun 70: 4818-4825, 2002


  16. Zou K, Kim D, Kakio A, Byun K, Gong JS, Kim M, Sawamura N, Nishimoto S, Matsuzaki K, Lee B, Yanagisawa K, Michikawa M: Amyloid β-protein (Aβ) 1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brain. J Neurochem 87: 609-619, 2003


  17. Sawamura N, Gong JS, Chang TY, Yanagisawa K, Michikawa M: Promotion of tau phosphorylation by MAP Kinase Erk1/2 Is accompanied by reduced cholesterol level in detergent-Insoluble membrane domains in Niemann-Pick C1-deficient cells. J Neurochem 84: 1086-1096, 2003


  18. Sai X, Kokame K, Shiraishi H, Kawamura Y, Miyata T, Yanagisawa K, Komano H: The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid β-protein generation. FEBS Lett 553: 151-156, 2003


  19. Shiraishi H, Sai X, Wang H, Maeda Y, Kuron Y, Nishimura M, Yanagisawa K, Komano H: PEN-2 enhances γ-cleavage after presenilin heterodimer formation. J Neurochem 90: 1402-1413, 2004


  20. Yamamoto N, Igbabvoa U, Shimada Y, Ohno-Iwashita Y, Kobayashi M, Wood WG, Fujita SC, Yanagisawa K: Accelerated Aβ aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain. FEBS Lett 569: 135-139, 2004


  21. Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein. J Neurochem 90: 62-69, 2004


  22. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao, K Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K: A seed for Alzheimer amyloid in the brain. J Neurosci 24: 4894- 4902, 2004


  23. Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong JS, Yanagisawa K, Michikawa M: Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem 279: 11984-11991, 2004


  24. Yu W, Gong JS, Ko M, Garver WS, Yanagisawa K, Michikawa M: Altered cholesterol metabolism in Niemann-Pick Type C1 mouse brain affects mitochondria function. J Biol Chem 280: 11731-11739, 2005


  25. Yu W, Zou K, Gong JS, Ko M, Yanagisawa K, Michikawa M: Oligomerization of amyloid β-protein occurs during the isolation of lipid rafts, J Neurosci Res 80: 114-119, 2005


  26. Kimura N, Yanagisawa K, Terao K, Ono F, Sakakibara I, Ishii Y, Kyuwa S, Yoshikawa Y: Age-related changes of intracellular Aβ in cynomolgus monkey brains, Neuropathol Applied Neurobiol 31: 170-180, 2005


  27. Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Van Nostrand WE, Yanagisawa K: Assembly of hereditary amyloid β-protein variants in the presence of favorable gangliosides. FEBS Lett 579: 2185-2190, 2005


  28. Igbavboa U, Eckert GP, Malo TM, Studniski AE, Johnson LN, Yamamoto N, Kobayashi M, Fujita SC, Appel TR, Muller WE, Wood WG, Yanagisawa K: Murine synaptosomal lipid raft protein and lipid composition are altered by expression of human apoE 3 and 4 and by increasing age. J Neurol Sci 229-230: 225-232, 2005


ΉY@͈@iwEw@ȁj
  1. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. Int J Mol Med 5: 269-735, 2000


  2. Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S: Metabolism of amyloid precursor protein in COS cells transfected with a β-secretase candidate. Cytotechnology 33: 213-219, 2000


  3. Tagawa K, Taya C, Hayashi Y, Nakagawa M, Ono Y, Fukuda R, Karasuyama H, Toyama-Sorimachi N, Katsui Y, Hata S, Ishiura S, Nonaka I, Seyama Y, Arahata K, Yonekawa H, Sorimachi H, Suzuki K: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet 9: 1393-1402, 2000


  4. Fuke S, Suo S, Takahashi N, Koike H, Sasagawa N, Ishiura S: The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression. Pharmacogenomics J 1: 152-156, 2001


  5. Umeda T, Kouchi Z, Kawahara H, Tomioka S, Sasagawa N, Maeda T, Sorimachi H, Ishiura S, Suzuki K: Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells. J Biochem 130: 535-542, 2001


  6. Ishiura S, Hotoda N, Szabo B, Asai M, Hattori C, Tanaka E, Koike H, Sasagawa N: Alzheimer amyloid α-secretase: a special target for drug development. Psychogeriatrics 1: 273-276, 2001


  7. Suo S, Sasagawa N, Ishiura S: Identification of a dopamine receptor from Caenohabditis elegans. Neurosci Lett 319: 13-16, 2002


  8. Suzuki T, Nakagawa M, Yoshikawa A, Sasagawa N, Yoshimori T, Ohsumi Y, Nishino I, Ishiura S, Nonaka I: The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem 131: 647-651, 2002


  9. Hotoda N, Koike H, Sasagawa N, Ishiura S: A secreted form of ADAM9 has an α-secretase activity for APP. Biochem Biophys Res Commun 293: 800-805, 2002


  10. Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S: BACE1 interacts with nicastrin. Biochem Biophys Res Commun 293: 1228-1232, 2002


  11. Asai M, Hattori C, Szabo B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S: Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase. Biochem Biophys Res Commun 301: 231-235, 2003


  12. Yoshikawa A, Mitsuhashi H, Sasagawa N, Tsukahara T, Hayashi Y, Nishino I, Goto Y, Ishiura S: Expression of ARPP-16/19 in rat denervated skeletal muscle. J Biochem 134: 57-61, 2003


  13. Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y: Potential link between amyloid beta protein 42 and C-terminal fragment gamma49-99 of beta amyloid precursor protein. J Biol Chem 278: 24294-24301, 2003


  14. Suo S, Sasagawa N, Ishiura S: Cloning and characterization of a C. elegans D2-like dopamine receptor. J Neurochem 86: 869-878, 2003


  15. Shuto D, Kasai S, Kimura T, Liu P, Hidaka K, Hamada T, Shibakawa S, Hayashi Y, Hattori C, Szabo B, Ishiura S, Kiso Y: KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: Design and synthesis of substrate-based octapeptides. Bioorg Med Chem Lett 13: 4273-4276, 2003


  16. Kinouchi T, Ishiura S, Mabuchi Y, Urakami-Manaka Y, Nishio H, Nishiuchi Y, Tsunemi M, Takada K, Watanabe M, Ikeda M, Matsui H, Tomioka S, Kawahara H, Hamamoto T, Suzuki K, Kagawa Y: Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging. Biochem Biophys Res Commun 314: 730-736, 2004


  17. Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S: ADAMs, a disintegrin metalloproteinases, mediate shedding of oxytocinase. Biochem Biophys Res Commun 314: 1008-1013, 2004


  18. Kino Y, Oma Y, Sasagawa N, Ishiura S: Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats. Hum Mol Genet 13: 495-507, 2004


  19. Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004


  20. Oma Y, Kino Y, Sasagawa N, Ishiura S: Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells. J Biol Chem 279: 21217-21222, 2004


  21. Szabo B, Hori K, Nakajima A, Sasagawa N, Watanabe Y, Ishiura S: Expression of amyloid-beta 1-40 and 1-42 peptides in Capsicum annum var. angulosum for oral immunization. Assay Drug Dev Technol 2: 383-388, 2004


  22. Suo S, Ishiura S, Van Tol HH: Dopamine receptors in C. elegans. Eur J Pharmacol 500: 159-166, 2004


  23. Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Muyarama S, Ihara Y: Independent accumulations of tau and amyloid β protein in the human entorhinal cortex. Neurology 64: 687-692, 2005


  24. Fuke S, Sasagawa N, Ishiura S: Identification and characterization of Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3f non-coding polymorphic region of the human dopamine transporter (DAT1) gene. J Biochem 137: 205-216, 2005


  25. Oma Y, Kino Y, Sasagawa N, Ishiura S: Comparative analysis of the cytotoxicity of homopolymeric amino acids. Biochim Biophys Acta 1748: 174-179, 2005


  26. Mitsuhashi H, Yoshikawa A, Sasagawa N, Hayashi Y, Ishiura S: Denervation enhances the expression of SHPS-1 in the rat skeletal muscle. J Biochem 137: 495-502, 2005


  27. Sugiura M, Fuke S, Suo S, Sasagawa N, Van Tol HH, Ishiura S: Characterization of a novel D2-like dopamine receptor with a truncated splice variant and a D1-like dopamine receptor unique to invertebrates from Caenorhabditis elegans. J Neurochem 94: 1146-1157, 2005


@FiwE]ȊwZ^[j
  1. Takashima A, Murayama M, Yasutake K, Takahashi H, Yokoyama M, Ishiguro K: Involvement of cyclin dependent kinase 5 activator p25 on tau phosphorylation in mouse brain. Neurosci Lett306: 37-40, 2001


  2. Yoshiike Y, Tanemura K, Murayama O, Akagi T, Murayama M, Sato S, Sun X, Tanaka N, Takashima A: New insights on how metals disrupt amyloid β-aggregation and their effects on amyloid-β cytotoxicity. J Biol Chem 276: 32293-32299, 2001


  3. Palacino JJ, Murphy MP, Murayama O, Iwasaki K, Fujiwara M, Takashima A, Golde TE, Wolozin B: Presenilin 1 regulates beta-catenin-mediated transcription in a GSK 3beta-independent fashion. J Biol Chem 276: 38563-38569, 2001


  4. Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park JM, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A: Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis 8: 1036-1045, 2001


  5. Kimura N, Nakamura SI, Honda T, Takashima A, Nakayama H, Ono F, Sakakibara I, Doi K, Kawamura S, Yoshikawa Y: Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain. Brain Res 922: 30-41, 2001


  6. Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Frautschy SA, Takashima A: Intracellular Aβ is increased by okadaic acid exposure in the transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2002


  7. Sun X, Sato S, Murayama O, Murayama M, Park J-M, Yamaguchi H, Takashima A: Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 15: 61-64, 2002


  8. Tanemura K, Akagi T, Murayama M, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A:  Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002


  9. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H: The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin- independent mechanisms. Proc Natl Acad Sci USA 99: 8760-8765, 2002


  10. Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H: Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's beta-amyloid fibrils in vitro. J Neurochem 81: 434-440, 2002


  11. Sato S, Tatebayashi Y, Akagi T, Chui DH, Murayama M, Miyasaka T, Planel E, Tanemura K, Sun X, Hashikawa T, Yoshioka K, Ishiguro K, Takashima A: Aberrant tau phosphorylation by GSK-3β and JNK-3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem 277: 42060-42065, 2002


  12. Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H: Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100: 721-726, 2003


  13. Kwok JB, Halliday GM, Brooks WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vickers J, Wang R, Naslund J, Takashima A, Gandy SE, Schofield PR: Presenilin-1 mutation (Leu271Val) results in altered exonic splicing and Alzheimerfs disease with non-cored plaques and neuritic dystrophy. J Biol Chem 278: 6748-6754, 2003


  14. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M: Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87: 172-181, 2003


  15. Sekiguchi H, Okajima T, Arakawa H, Maeda S, Ikai A, Takashima A: Frequency shift feedback imaging in liquid for biological molecules. Appl Surface Sci 210:61-67, 2003


  16. Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK: A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645, 2003


  17. Yoshiike Y, Chui DH, Akagi T, Tanaka N, Takashima A: Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation. J Biol Chem 278: 23648-23655, 2003


  18. Kimura N, Tanemura K, Nakamura S, Takashima A, Ono F, Sakakibara I, Ishii Y, Kyuwa S, Yoshikawa Y: Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Commun 310: 303-311, 2003


  19. Shigetsugu H, Matsumoto M, Kamura T, Murayama M, Chui D-H, Planel E, Takahashi R, Nakayama K-I, Takashima A: U-box protein carboxyl terminus of Hsc7-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy. J Neurochem 91: 299-307, 2004


  20. PlanelE, Miyasaka T, Launey T, Chui D-H, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, TakashimaA: Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation: mechanism and implications for Alzheimer's disease. J Neurosci 24: 2401-2411, 2004


  21. Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I: Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants .J Neurosci Res 75: 417-428, 2004


@biwE]ȊwZ^[j
  1. Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee HJ, Hama E, Sekine-Aizawa Y, Saido TC: Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition. Nat Med 6: 143-151. 2000


  2. Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK:  Preferential deposition of truncated amyloid-β peptides in brain of presenilin 1 gene mutation carriers. Nature 405:  531-532, 2000


  3. Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VM, Trojanowski JQ: Brain trauma in aged transgenic mice induces regression of established abeta deposits. Exp Neurol 163: 244-252, 2000


  4. Lankiewicz S, Marc Luetjens C, Truc Bui N, Krohn AJ, Poppe M, Cole GM, Saido TC, Prehn JH: Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J Biol Chem 275: 17064-17071, 2000


  5. Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T: Age-related Aβ deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and β amyloid precursor protein is not associated with global neuronal loss. Am J Pathol157: 331-339, 2000


  6. Hiwasa T, Arase Y, Kikuno K, Hasegawa R, Sugaya S, Kita K, Saido T, Yamamori H, Maki M, Suzuki N: Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ 7: 531-537, 2000


  7. Iwata N, Tsubuki S, Hama E, Takaki Y, Shirotani K, Saido TC: Clearance of amyloid β-peptide from brain: transport or metabolism? Nat Med 6: 718-719, 2000


  8. Harigaya Y, Saido TC, Eckman CB, Prada C-M, Shoji M, Younkin S: Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochem Biophys Res Commun 276: 422-427, 2000


  9. Lee H-J, Tomioka M, Takaki Y, Masumoto H, Saido TC: Molecular cloning and expression of aminopeptiase A isoforms from rat hippocampus. Biochim Biophys Acta 1493: 273-278, 2000


  10. Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee HJ, Shirotani K, Saido TC: Identification of the neutral endopeptidase family member responsible for the catabolism of amyloid β peptide in brain. J Biochem 128: 897-902, 2000


  11. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, cerebrospinal fluid, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimerfs disease. J Neurosci 21: 372-381, 2001


  12. Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S: Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate. Cytotechnology 33: 213-219, 2000


  13. Kitagaki H, Tomioka S, Yoshizawa T, Sorimachi H, Saido TC, Ishiura S, Suzuki K: Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain. Biosci Biotechnol Biochem 64: 689-695, 2000


  14. Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S: Age-related amyloid beta protein accumulation induces cellular death and macrophage activation in transgenic mice. J Pathol 191: 93-101, 2000


  15. Yamaguchi A, Yamamoto N, Akamatsu N, Saido TC, Kaneda M, Umeda M, Tanoue K: PS-liposome and ox-LDL bind to different sites of the immunodominant domain of CD36: a study with GS95, a new anti-CD36 monoclonal antibody. Thromb Res 97: 317-326, 2000


  16. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. Int J Mol Med 5: 269-273, 2000


  17. Taniguchi S, Fujita Y, Takahashi H, Hayashi S, Kakita A, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Degradation of p35 to p25 in postmortem human and rat brains. FEBS Lett 46-50, 2001


  18. Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC: Matrix metalloproteinase (MMP) system in brain: Identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci 13: 935-948, 2001


  19. Kiryu-Seo S, Kiyama H, Iwata H, Tomita T, Iwatsubo T, Saido TC: Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases. J Biol Chem 276: 21895-21901, 2001


  20. Choi W-S, Lee E-H, Chung C-W, Jung Y-K, Jin BK, Kim SU, Oh TH, Saido TC, Oh YJ: Cleavage of Bax is mediated by caspase-dependent or -independent calpain activation in dopaminergic neuronal cells: Protective role of Bcl-2. J Neurochem 77: 1531-1541, 2001


  21. Iwata N, Tsubuki S, Takaki Y, Shirotani K, Lu B, Gerard NP, Gerard C, Hama E, Lee H-J, Saido TC: Metabolic regulation of brain Aβ by neprilysin. Science 292: 1550-1552, 2001


  22. Kaneko T, Yamashima T, Tohma Y, Nomura M, Imajoh-Ohmi S, Saido TC, Nakao M, Saya H, Yamamoto H, Yamashita J: Calpain-dependent proteolysis of merlin occurs by oxidative stress in meningiomas: a novel hypothesis for tumorigenesis. Cancer 92: 2662-2672, 2001


  23. Hama E, Shirotani K, Masumoto H, Sekine-Aizawa Y, Aizawa H, Saido TC: Clearance of extracellular and cell-associated amyloid β peptide by viral expression of neprilysin in primary culture. J Biochem 130: 721-726, 2001


  24. Russo C, Schettini G, Saido TC, Gambetti P, Tabaton M, Teller JT: N-terminally truncated amyloid β peptides and Alzheimerfs disease. Neurobiol Aging 22: 345, 2001


  25. Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y: Alzheimerfs β-secretase, β-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferease. Proc Natl Acad Sci USA 98: 13554-13559, 2001


  26. Kim JE, Han BS, Choi WS, Eom DS, Lee EH, Oh TH, Markelonis GJ, Saido TC, Lee GE, Chung IK, Oh YJ: Temporospatial sequence of cellular events associated with etoposide-induced neuronal cell death: role of antiapoptotic protein Bcl-X(L). J Neurosci Res 66:1074-1082, 2001


  27. Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, St George-Hyslop P, Saido TC: Aβ-degrading endopeptidase, neprilysin, in mouse brain: Synaptic and axonal localization inversely correlating with Aβ pathology. Neurosci Res 43: 39-56, 2001


  28. Shirotani K, Tsubuki S, Lee H-J, Maruyama K, Saido TC: Generation of amyloid β peptide with pyroglutamate at position 3 in primary cortical neurons. Neurosci Lett 327: 25-28, 2002


  29. Fukami S, Iwata N, Saido TC: Therapeutic strategies of Alzheimerfs disease through manipulation of Aβ metabolism: a focus on Aβ-degrading peptidase, neprilysin. Drug Develop Res 56: 171-183, 2002


  30. Takahashi M, Fukami S, Iwata N, Inoue K, Itohara S, Itoh H, Haraoka J, Saido TC: In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacol Res 46: 155-163, 2002


  31. Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC: Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res 70: 493-500, 2002


  32. Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S: BACE1 interacts with nicastrin. Biochem Biophys Res Commun 293: 228-1232, 2002


  33. Tomioka M, Shirotani K, Iwata N, Lee HJ, Yang F, Cole GM, Seyama Y, Saido TC: In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal brain. Mol Brain Res 108: 18-32, 2002


  34. Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA: Intraneuronal Aβ42 accumulation in Down syndrome brain. Amyloid 9: 88-102, 2002


  35. Kuwano K, Nisimura I, Uetsuki T, Saido TC, Yoshikawa K: Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Mol Brain Res 107: 166-175, 2002


  36. Dare E, Tofighi R, Vettori MV, Momoi T, Poli D, Saido TC, Mutti A, Ceccatelli S: Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Res 933: 12-22, 2002


  37. Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido TC, Hashimoto Y: Characterization of α2,6-siaryltransferase cleavage by Alzheimerfs β-secretase (BACE1). J Biol Chem 278: 14865-14871, 2003


  38. Kitazume S, Saido TC, Hashimoto Y: Alzheimerfs β-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconj J 278: 14865-14871, 2003


  39. Tsubuki S, Takaki Y, Saido TC: Dutch, Flemish, Italian, and Arctic mutations of APP and resistance of Aβ to physiologically relevant proteolytic degradation. Lancet 361: 1957-1958, 2003


  40. Zhang J, Miyamoto K, Hashioka S, Hao H P, Murao K, Saido TC, Nakanishi H: Activation of µ-calpain in developing cortical neurons following methylmercury treatment. Dev Brain Res 142: 105-110, 2003


  41. Porn-Ares I, Saido TC, Tommy A, Ares MPS: Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J 374: 403-411, 2003


  42. Yokota M, Saido TC, Kamitani H, Tabuchi S, Satokata I, Watanabe T: Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain. Brain Res 984: 122-132, 2003


  43. Rami A, Volkmann T, Agarwal R, Schoninger S, Nuernberger F, Saido TC, Winckler J: β2-adrenergic receptor responsiveness of the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neurosci Res 47: 373-382, 2003


  44. Wang D-S, Iwata N, Hama E, Saido TC, Dickson DW: Oxidized neprilysin in aging and Alzheimerfs disease brains. Biochem Biophys Res Commun 310: 236-241, 2003


  45. Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E: Sustained calpain activation associated with lysosomal rapture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus 13: 791-800, 2003


  46. Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R: The crucial role of caspase-9 in the disease progression of transgenic ALS mouse model. EMBO J 22: 6665-6674, 2003


  47. Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor protein missense mutation in probable Alzheimerfs disease. J Neurol Neurosurg Psychiat 75: 1039-1042, 2004


  48. Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Gerard N, Gerard C, Ozawa K, Saido TC: Presynaptic localization of neprilysin contributes to efficient clearance of amyloid β peptide in mouse brain. J Neurosci 24: 991-998, 2004


  49. Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylmorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004


  50. Kitazume S, Saido TC, Hashimoto Y: Alzheimerfs β-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconj J 20: 59-62, 2004


  51. Hama E, Shirotani K, Iwata N, Saido TC: Effects of neprilysin chimeric proteins targeted to subcellular compartments on amyloid β peptide clearance in primary neurons. J Biol Chem 279: 30259-30264, 2004


  52. Sato K, Higuchi M, Iwata N, Saido TC, Sasamoto K: Fluoro-substituted and 13C-labled styrylbenzene derivatives for detecting brain amyloid plaques. Eur J Med Chem 39: 573-578, 2004


  53. Ladrech S, Guitton M, Saido T, Lenoir M: Calpain activity in the amikacin-damaged rat cochlea. J Comp Neurol 477: 149-160, 2004


  54. Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y: Truncated carboxyl-terminal fragments of β-amyloid precursor protein are processed to amyloid β-proteins 40 and 42. Biochemistry 43: 13532-13540, 2004


  55. Bialkowska K, Saido TC, Fox JEB: SH3 domain of spectrin participates in the activation of Rac in specialized calpain-induced integrin signaling complexes. J Cell Sci 118: 381-395, 2004


  56. Shin RW, Saido TC, Maeda M, Kitamoto T: Novel a-secretase cleavage of Alzheimerfs amyloid β precursor protein in the endoplasmic reticulum of COS7 cells. Neurosci Lett 376: 14-19, 2005


  57. Saito T, Iwata N, Tsubuki S, Takaki Y, Takano J, Huang S-H, Suemoto T, Higuchi M, Saido TC: Somatostatin regulates brain amyloid β peptide, Aβ42, through modulation of proteolytic degradation. Nat Med 11: 434-439, 2005


  58. Qi-Takahara Y, Morishima-Kawashima M, Tanimura Y, Dolios G, Hirotani N, Horikoshi Y, Kametani F, Maeda M, Saido TC, Wang R, Ihara Y: Longer forms of amyloid β protein: Implications for the mechanism of intramembrane cleavage by γ-secretase. J Neurosci 25: 436-445, 2005


  59. Takano J, Tomioka M, Tsubuki T, Higuchi M, Iwata N, Itohara S, Maki M, Saido TC: Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways: evidence from calpastatin-mutant mice. J Biol Chem 280: 16175-16184, 2005


  60. Higuchi M, Tomioka M, Takano J, Shirotani K, Iwata N, Masumoto H, Maki M, Itohara S, Saido TC: Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice over-expressing their specific inhibitors. J Biol Chem 280: 15229-15237, 2005


  61. Higuchi M, Iwata N, Matsuba Y, Sato K, Sasamoto K, Saido TC: 19F- and 1H-MRI detection of amyloid-β peptide in vivo. Nat Neurosci 8: 527-533, 2005


  62. Kokubo H, Saido TC, Iwata N, Helms JB, Shinohara R, Yamaguchi H: Part of membrane-bound Aβ exists in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging 26: 409-418, 2005


  63. Kambe A, Yokota M, Saido TC, Sakokata I, Fujikawa H, Tabushi S, Kamitani H, Watanabe T: Spatial resolution of calpain-catalyzed proteolysis in focal cerebral ischemia. Brain Res 1040: 36-43, 2005


  64. Hayashi M, Koshihara Y, Ishibashi H, Yamamoto S, Tsubuki S, Saido TC, Kawashima S, Inomata M: Involvement of calpain in osteoclastic bone resorption. J Biochem 137: 331-338, 2005


  65. Sato T, Tanimura Y, Hirotani N, Saido TC, Morishima-Kawashima M, Ihara Y: Blocking the cleavage at midportion between γ- and ε- sites remarkably suppresses the generation of amyloid β-protein. FEBS Lett 579: 2907-2912, 2005


  66. Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamagushi H: Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res 1045: 224-228, 2005


@iȑwEq_oȊwZ^[j
  1. Van Gassen G, De Jonghe C, Nishimura M, Yu G, Kuhn S, St George-Hyslop P, Van Broeckhoven C: Evidence that the β-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction. Mol Med 6: 570-580, 2000


  2. Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, St George-Hyslop P: Mutation of conserved aspartates affect maturation of both aspartate-mutant and endogenous presenilin 1 and presenilin 2 complexes. J Biol Chem 275: 27348-27353, 2000


  3. Zhang DM, Levitan D, Yu G, Nishimura M, Chen F, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Liang Y, Holmes E, Milman P, Sato C, Zhang L, St George-Hyslop P: Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans. NeuroReport 11: 3227-3230, 2000


  4. Yu G, Nishimura M, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer L, Sorbi S, Bruni A, Fraser PE, St George-Hyslop P: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing. Nature 407: 48-54, 2000


  5. Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE: Carboxyl-terminal fragments of Alzheimer β-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1 deficient cells. J Biol Chem 275: 36794-36802, 2000


  6. Fraser PE, Yang D, Yu G, Levesque L, Nishimura M, Arawaka S, Serpell LC, Rogaeva E, St George-Hyslop P: Presenilin structure, function and role in Alzheimer disease. Biochim Biophys Acta 1502: 1-15, 2000


  7. Chen F, Yu G, Arawaka S, Nishimura M, Kawarai T, Yu H, Tandon A, Supala A, Song YQ, Rogaeva E, Milman P, Sato C, Yu C, Janus C, Lee J, Song L, Zhang L, Fraser PE, St George-Hyslop PH: Nicastrin binds to membrane-tethered Notch. Nat Cell Biol 3: 751-754, 2001


  8. Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P: Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP. Neurobiol Aging 23: 187-194, 2002


  9. Wang HQ, Takebayashi K, Tsuchida K, Nishimura M, Noda Y: Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. J Clin Endocrinol Metab 88: 4432-4439, 2003


  10. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T: Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279: 24343-24354, 2004


  11. Shiraishi H, Sai X, Wang HQ, Maeda Y, Kurono Y, Nishimura M, Yanagisawa K, Komano H: PEN-2 enhances γ-cleavage after presenilin heterodimer formation. J Neurochem 90: 1402-1413, 2004


  12. Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M: Random mutagenesis of presenilin 1 identifies novel mutants exclusively generating long amyloid β peptides. J Biol Chem 280: 19070-19077, 2005


  13. Wang HQ, Nakaya Y, Du Z, Yamane T, Shirane M, Kudo T, Takeda M, Takebayashi K, Noda Y, Nakayama KI, Nishimura M: Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2. Hum Mol Genet 14: 1889-1902, 2005


X@[iswEw@wȁj
  1. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido T, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-,µ-calpain. Int J Mol Med 5: 269-273, 2000


  2. Lippa CF, Schmidt ML, Nee LE, Bird T, Nochlin D, Hulette C, Mori H, Lee VM-Y, Trojanowski JQ: AMY plaques in familial AD: Comparison with sporadic Alzheimerfs disease. Neurology 54: 100-104, 2000


  3. Sahara N, Tomiyama T, Mori H: Missemse point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation. J Neurosci Res 60: 380-387, 2000


  4. Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimerfs disease. Neurology 54: 2319-2321, 2000


  5. Shimizu T, Watanabe A, Ogawara M, Mori H, Shirasawa T: Isoaspartate formation and neurodegeneration in Alzheimerfs disease. Arch Biochem Biophys 381: 225-234, 2000


  6. Cavani S, Tamaoka A, Moretti A, Marinelli L, Angelini G, Di Stefano S, Piombo G, Cazzulo V, Matsuno S, Shoji S, Furiya Y, Zaccheo D, Dagna-Bricarelli F, Tabaton M, Mori H: Plasma levels of amyloid β40 and 42 are independent from apoE genotype and mental retardation in Down syndrome. Am J Med Genet 95: 224-228, 2000


  7. Pigino G, Pelsman A, Mori H, Busciglio J: Presenilin 1 mutations reduce cytoskeletal association, deregulate neurite growth and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21: 834-842, 2001


  8. Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St. George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H: Distinguishable effects of Presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22: 367-376, 2001


  9. Takahashi K, Kamiya K, Urase K, Suga M, Takizawa T, Mori H, Yoshikawa Y, Ichimura K, Kuida K, Momoi T: Caspase-3-deficiency induces hyperplasia of supporting cells and degeneration of sensory cells resulting in the hearing loss. Brain Res 894: 359-367, 2001


  10. Park I-H, Jung MW, Mori H, Inhee M-J: Zinc enhances synthesis of presenilin 1 in mouse primary cortical culture. Biochem Biophys Res Commun 285: 680-688, 2001


  11. Kametani F, Tanaka K, Usami M, Maruyama K, Mori H: Human wild presenilin-1 mimics the effect of the mutant presenilin-1 on the processing of Alzheimerfs amyloid precursor protein in PC12D cells. J Neurol Sci 188: 27-31, 2001


  12. Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, Hashimoto T, Terashima A, Nakai M, Mori H, Ono Y, Tanaka C: Phosphorylation of tau is regulated by PKN. J Biol Chem 276: 10025-10031, 2001


  13. Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA: Altered metabolism of the amyloid β precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33: 677-688, 2002


  14. Ishii K, Klunk WE, Arawaka S,Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A,Pettegrew, JW, Mori H: Chrysamine G and its derivative reduce amyloid β-induced neurotoxicity in mice. Neurosci Lett 333: 5-8, 2002


  15. Yuasa S, Nakajima M, Aizawa H, Sahara N, Koizumi K, Sakai T, Usami M, Kobayashi S, Kuroyanagi H, Mori H, Koseki H, Shirasawa T: Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res 70: 501-513, 2002


  16. Ozawa K, Tomiyama T, Maat-Schieman ML, Roos RA, Mori H: Enhanced Abeta40 deposition was associated with increased Abeta42-43 in cerebral vasculature with Dutch-type hereditary cerebral hemorrhage with amyloidosis (HCHWA-D). Ann NY Acad Sci 977: 149-154, 2002


  17. Mori H, Tomiyama T, Maeda N, Ozawa K, Wakasa K: Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome. Neuropathology 23: 51-56, 2003


  18. Takuma H, Arawaka S, Mori H: Isoforms changes of tau protein during development in various species. Dev Brain Res 142: 121-127, 2003


  19. Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G: Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes. Biochem Biophys Res Commun 301: 119-126, 2003


  20. Minami M, Mizutani T, Kawanishi R, Suzuki R, Mori H: Neuronal expression of αB crystallin in cerebral infarction. Acta Neuropathol 105: 549-554, 2003


  21. Hashimoto Y, Tomiyama T, Yamano Y, Mori H: Mutation (D472Y) in the type 3 repeat domain of cartilage oligomeric matrix protein (COMP) affects its early vesicle trafficking in ER and induces apoptosis. Am J Pathol 163: 101-110, 2003


  22. Kametani F, Usami M, Tanaka K, Kume H, Mori H: Mutant presenilin (A260V) affects Rab8 in PC12D cell. Neurochem Int 44: 313-320, 2003


  23. Kanemitsu H, Tomiyama T, Mori H: Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci Lett 350: 113-116, 2003


  24. Uchihara T, Nakamura A, Nakayama H, Arima K, Ishizuka N, Mori H, Mizushima S: Triple immunofluorolabeling with two rabbit polyclonal antibodies and a mouse monoclonal antibody allowing three-dimensional analysis of cotton wool plaques in Alzheimer disease. J Hisochem Cytochem 51: 1201-1206, 2003


  25. Takuma H, Tomiyama T, Kuida K, Mori H: Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. J Neuropathol Exp Neurol 63: 255-261, 2004


  26. Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada H, Tsutada T, Kawabata K, Mori H, Miki T: A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis. Arch Neurol 61: 1773-1776, 2004


  27. Suga K, Tomiyama T, Mori H, Akagawa K: Presenilin holoproteins, but not their N- or C-terminal fragments, interact with syntaxin 5. Biochem J 381: 619-628, 2004


  28. Yamashita T, Tomiyama T, Li Q, Numata H, Mori H: Regulation of tau exon 10 splicing by a double stem-loop structure in mouse intron 10. FEBS Lett 579: 241-244, 2005


  29. Ono T, Haratake M, Nakayama M, Kaneko Y, Kawabata K, Mori H, Kung MP, Kung HF: Synthesis and biological evaluation of (E)-3-styrylpyridine derivatives as amyloid imaging agents for Alzheimerfs disease. Nucl Med Biol 32: 329-335, 2005


V@N@is_wj
  1. Ikeda K, Akiyama H, Arai T, Kondo H, Haga C, Tsuchiya K, Yamada S, Murayama S, Hori A: Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain? Neurosci Lett 284: 187-189, 2000


  2. Ikeda K, Akiyama H, Arai T, Matsushita M, Tsuchiya K, Miyazaki H: Clinical aspects of argyrophilic grain disease. Clin Neuropathol 19: 278-284, 2000


  3. Arai T, Ikeda K, Akiyama H, Shikamoto Y, Tsuchiya K, Yagishita S, Beach T, Rogers J, Schwab C, McGeer PL:  Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pickfs disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol 101: 167-173, 2001


  4. Arai T, Ikeda K, Akiyama H, Tsuchiya K, Yagishita S, Takamatsu J: Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. NeuroReport 12: 935-938, 2001


  5. Arai T, Ikeda K: Phenotypic heterogeneity of FTDP-17: implications for the differences of pathological phenotype among sporadic tauopathies. Neurobiol Aging 22: 127-129, 2001


  6. Iseki E, Matsumura T, Marui W, Hino H, Odawara T, Sugiyama N, Suzuki K, Sawada H, Arai T, Kosaka K: Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells. Acta Neuropathol 102: 285-292, 2001


rc@@iQnwEw@wnȁj
  1. Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Chishti MA, Harigaya Y, Abe K, Okamoto K, St George-Hyslop P, Westaway D: Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol 166: 521-531, 2005


  2. Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004


  3. Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Maruyama Y, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25: 483-490, 2004


Έ@O@i}gwEՏwnj
  1. Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H: Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22:  367-376, 2001


  2. Ishii K, Tamaoka A, Shoji S: A case of primary focal lingual dystonia induced by speaking. Eur J Neurol 8: 507, 2001


  3. Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H: Chrysamine G and its derivative reduce amyloid beta-induced neurotoxicity in mice. Neurosci Lett 333: 5-8, 2002


  4. Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S: Prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid beta-peptides in CSF. Neurology 58: 1415-1418, 2002


o@瑩@iswEw@wȁj
  1. Asai K, Fujimoto K, Harazaki M, Kusunoki T, Korematsu S, Ide C, Ra C, Hosoi S: Distinct aggregation of beta- and gamma-chains of the high-affinity IgE receptor on cross-linking. J Histochem Cytochem 48: 1705-1716, 2000


  2. Chakrabortty S, Kitada M, Matsumoto N, Taketomi M, Kimura K, Ide C: Choroid plexus ependymal cells enhance the neurite outgrowth from dorsal root ganglion neurons in vitro. J Neurocytol 29: 707-717, 2000


  3. Shirasu M, Kimura K, Kataoka M, Takahashi M, Okajima S, Kawaguchi S, Hirasawa Y, Ide C, Mizoguchi A: VAMP-2 promotes neurite elongation and SNAP-25A increases neurite sprouting in PC12 cells.Neurosci Res 37: 265-275, 2000


  4. Nishida A, Takahashi M, Tanibara H, Nakano I, Takahashi J, Mizoguchi A, Ide C, Honda Y: Incorporation and differentiation of neural stem cells transplanted in injured adult rat retina. InvestOphthalmol Vis Sci 41: 4268-4274, 2000


  5. Okajima S, Shirasu M, Hirasawa Y, Ide C: Ultrastructural characteristics and synaptophysin immunohistochemistry of regenerating nerve growth cones following traumatic injury to rat peripheral nerve. J Reconstruct Microsurg 16: 637-642, 2000


  6. Yoshida Y, Morita K, Mizoguchi A, Ide C, Miyachi Y: Altered expression of occludin and tight junction formation in psoriasis. Arch Dermatol Res 293: 239-44, 2001


  7. Yoshida Y, Yoneda K, Umeda M, Ide C, Fujimoto K: Localization of sphingomyelin during the development of dorsal and tail epidermis of mice. Br J Dermatol 145: 758-770, 2001


  8. Shibuya Y, Yasuda H, Umeda M. Komori T, Ide C: Expression of R-cadherin in the regenerating chick sciatic nerve. Anat Embryol 204: 485-491, 2001


  9. Ide C, Kitada M, Chakrabortty S, Taketomi M, Matsumoto N, Kikukawa S, Mizoguchi A, Kawaguchi S, Endo K, Suzuki Y: Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord: A preliminary report. Exp Neurol 167: 242-51, 2001


  10. Mligiliche N, Kitada M, Ide C: Grafting of detergent-denatured skeletal muscles provides effective conduits for extension of regenerating axons in the rat sciatic nerve. Arch Histol Cytol 64: 29-36, 2001


  11. Mligiliche N, Tabata Y, Endoh K, Ide C: Peripheral nerve regeneration through a long detergent-denatured muscle autografts in rabbits. NeuroReport 12: 1719-22, 2001


  12. Kataoka K, Suzuki Y, Kitada M, Ohnishi K, Suzuki K, Tanihara M, Ide C, Nishimura Y: Alginate, a bioresorbable material derived from brown seaweed, enhances elongation of amputated axons of spinal cord in infant rats. J Biomed Mater Res 54: 373-384, 2001


  13. Kitada M, Chakrabortty S, Matsumoto M, Taketomi M, Ide C: Differentiation of choroid plexus ependymal cells into astrocytes after grafting into the prelesioned spinal cord in mice.Glia 36: 364-374, 2001


  14. Wu S, Suzuki Y, Kitada M, Kitaura M, Kataoka K, Takahashi J, Ide C, Nishimura Y: Migration, integration and differentiation of hippocampus-derived neurosphere cells after transplantation into injured rat spinal cord. Neurosci Lett 312: 173-176, 2001


  15. Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, Horan TP, Arakawa T, Yoshida H ,Nishikawa S, Itoh Y, Seiki M, Itohara S, Takahashi C, Noda M: The membrane-anchored MMP-inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell 107: 789-800, 2001


  16. Noda T, Fujimoto K, Ide C: Annulate lamellae are interconnected by three distinct cisternal structures. Acta Histochem Cytochem 34: 103-110, 2001


ɓ@m@iÉswEw@wȁj
  1. Tada T, Ito J, Asai M, Yokoyama S: Fibroblast growth factor 1 is produced prior to apolipoprotein E in the astrocytes after cryo-injury of mouse brain. Neurochem Int 45: 23-30, 2004


  2. Yamagata H, Chen Y, Akatsu H, Kamino K, Ito J, Yokoyama S, Yamagata T, Kosaka K, Miki T, Kondo I: Promoter polymorphism in fibroblast growth factor 1 gene increases risk of definite Alzheimerfs disease. Biochem Biophys Res Commun 321: 320-323, 2004


  3. Ito J, Nagayasu Y, Kheirollah A, Yokoyama S: Apolipoprotein A-I induces translocation of protein kinase Cα to a cytosolic lipid-protein particle in astrocytes. J Lipid Res 45: 2269-2276. 2004


  4. Ito J, Nagayasu Y, Lu R, Kheirollah A, Hayashi M, Yokoyama S: Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action. J Lipid Res 46: 679-686, 2005


ɓ@pW@iHcwEwj
  1. Motoyama S, Saito S, Alojado EM, Itoh H, Kitamura M, Suzuki H, Saito R, Moriyama H, Nakae N, Ogawa J, Inaba H: Hydrogen peroxide induces midzonal heat shock protein 72 and apoptosis in sinusoidal endothelial cells of hypoxic rat liver. Crit Care Med28: 1509-1514, 2000


  2. Iwabuchi A, Otaka M, Otani S, Jin M, Okuyama A, Itoh S, Sasahara H, Odashima M, Ivan P, Itoh H, Tashima Y, Masamune O, Watanabe S: Specific preinduction of 60-kDa heat shock protein (chaperonin homolog) by TRH does not protect clonic mucosa against acetic acid-induced lesion in rats. Digest Dis Sci 45: 1480-1489, 2000


  3. Kawamura K, Fukuda J, Itoh H, Ito K, Kodama H, Kumagai J, Kumagai A, Tanaka T: Chaperonin 10 in the rat oocytes and early embryos: its expression and activity for early pregnancy factor. Am J Reprod Immunol 44: 242-248, 2000


  4. Okubo A, Kinouchi H, Owada Y, Kunizuka H, Itoh H, Izaki K, Kondo H, Tashima Y, Yoshimoto T, Mizoi K: Simultaneous induction of mitochondrial heat shock protein mRNAs in rat forebrain ischemia. Mol Brain Res 84: 127-134, 2000


  5. Kumagai J, Fukuda J, Kodama H, Murata M, Kawamura K, Itoh H, Tanaka T: Germ cell-specific heat shock protein 105 binds to p53 in a temperature-sensitive manner in rat testis. Eur J Biochem 267: 3073-3078, 2000


  6. Takahashi S, Wakui H, Gustafsson AJ, Zilliacus J, Itoh H: Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein. Biochem Biophys Res Commun 274: 87-92, 2000


  7. Hamada F, Narita M, Makabe A, Itoh H: The Effect of dansyl-modified-β-cyclodextrin on the chaperone activity of heat shock proteins. J Inclusion Phenomena Macrocyclic Chem 40: 83-88, 2001


  8. Izaki K, Kinouchi H, Watanabe K, Owada Y, Okubo A, Itoh H, Kondo H, Tashima Y, Tamura S, Yoshimoto T, Mizoi K: Induction of mitochondrial heat shock protein 60 and 10 mRNAs following transient focal cerebral ischemia in the rat. Mol Brain Res 88: 14-25, 2001


@G@iswEw@Ȋwȁj
  1. Sadot E, Simcha I, Iwai K, Ciechanover A, Geiger B, Ben-Ze'ev A: Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system. Oncogene 19: 1992-2001, 2000


  2. Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israel A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A: SCFβ-TrCP ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase. EMBO J 19: 2580-2591, 2000


  3. Shimura H, Hattori N, Kubo S-I, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinson's disease gene product, Parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305, 2000


  4. Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW: Activation of HIF1α ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97: 10430-10435, 2000


  5. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer IIIR, Grinberg A, Love P, Tresser N, Rouault T: Targeted deletion of iron regulatory protein 2 causes iron overload and neurodegenerative disease in mice. Nat Genet 27: 209-214, 2001


  6. Kawakami T, Chiba T, Suzuki T, Yamanaka K, Iwai K, Minato N, Hidaka Y, Shimbara N, Suzuki H, Osaka F, Omata M, Tanaka K: NEDD8 recruits E2-ubiquitin to SCF E3 ligase. EMBO J 20: 4003-4012, 2001


  7. Ciechanover A, Gonen H, Bercovich B, Cohen S, Fajerman I, Israel A, Mercurio F, Kahana C, Schwartz AL, Iwai K, Orian A: Mechanisms of ubiquitin-mediated, limited processing of the NF-κB1 precursor protein p105. Biochimie 83: 341-349, 2001


  8. Okuda H, SaitohK, HiraiS-I, Iwai K, Takaki Y, Baba M, MinatoN, Ohno S, ShuinT:The Von Hippel-Lindau (VHL) tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem 276: 43611-43617, 2001


Ac@@iBwEw@w@j
  1. Kline-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Duchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H: Long-range interactions within a nonnative protein. Science 295: 1719-1722, 2002


  2. Monji A, Utsumi H, Ueda T, Imoto T, Yoshida I, Hashioka S, Tashiro K, Tashiro N: Amyloid-beta-protein (Abeta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides. Life Sci 70: 833-841, 2002


  3. Ohmura T, Motoshima H, Ueda T, Imoto T: Fluctuations in free or substrate-complexed lysozyme and its mutant detected by X-ray crystallography and comparison with those on NMR. J Biochem 133: 701-704, 2002


  4. Ohkuri T, Ueda T, Yoshida Y, Abe Y, Hamasaki N, Imoto T: A metal binding in the polypeptide chain improves the folding efficiency of a denatured and reduced protein. Biopolymers 64: 106-114, 2002


  5. Ueda T, Nagata M, Monji A, Yoshida I, Tashiro N, Imoto T: Effect of sucrose on formation of the beta-amyloid fibrils and D-aspartic acids in Abeta 1-42. Biol Parm Bull 25: 375-378, 2002


  6. Tsujihata Y, Mizukami Y, Ueda T, So T, Imoto T: B-cell repertoire specific for an unfolded self-determinant of mouse lysozyme escape tolerance and dominantly participate in autoantibody response. Immunology 107: 394-402, 2002


  7. Masumoto K, Ueda T, Nagata M, Yamada Y, Yoshida Y, Hashimoto Y, Imoto T: Effects of stereochemistry of sugars on protein stabilities. Prot Pept Lett 9: 435-439, 2002


  8. Obita T, Iwakura T, Suetsugu M, Yoshida Y, Tanaka Y, Katayama T, Ueda T, Imoto T: Determination of the secondary structure in solution of the Escherichia coli DnaA DNA-binding domain. Biochem Biophys Res Commun 299: 42-48, 2002


  9. Nishida S, Fujimitsu K, Sekimizu K, Ohmura T, Ueda T, Katayama T: A nucleotide switch in the Escherichia coli DnaA protein initiates chromosomal replication: evidence from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo. J Biol Chem 277: 14986-14995, 2002


  10. Obita T, Ueda T, Imoto T: Solution structure and activity of mouse lysozyme M. Cell Mol Life Sci 60: 176-184, 2003


  11. Numata T, Suzuki A, Kakuta Y, Kimura K, Yao M, Tanaka I, Yoshida Y, Ueda T, Kimura M: Crystal structures of the ribonuclease MC1 mutants N71T and N71S in complex with 5'-GMP: structural basis for alterations in substrate specificity. Biochemistry 42: 5270-5278, 2003


  12. Kameoka D, Ueda T, Imoto T: A method for the detection of asparagine deamidation and aspartate isomerization of proteins by MALDI/TOF-mass spectrometry using endoproteinase Asp-N. J Biochem 134: 129-135, 2003


  13. Takeshita K, Hashimoto Y, Ueda T, Imoto T: A small chimerically bifunctional monomeric protein: Tapes japonica lysozyme. Cell Mol Life Sci 60: 1944-1951, 2003


  14. Yoshida Y, Obita T, Kokusho Y, Ohmura T, Katayama T, Ueda T, Imoto T: Identification of the region in Escherichia coli DnaA protein required for specific recognition of the DnaA box. Cell Mol Life Sci 60: 1998-2008, 2003


͓@N@iwEw@wnȁj
  1. Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, KudoT, Takeda M, Haass C: Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J 21: 5408-5416, 2002


  2. Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C: Presenilin dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem 277:44754-44759, 2002


  3. Yasuda Y, Kudo T, Katayama T, Imaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M: FAD-linked presenilin-1 mutants impede translation regulation under ER stress. Biochem Biophys Res Commun 296: 313-318, 2002


  4. Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C: Identification of a beta-secretase activity, which truncates amyloid beta-peptide after its presenilin dependent generation. J Biol Chem 278: 5531-5538, 2003


  5. Okochi M, Takeda M: Possible assessment of Alzheimerfs γ-secretase activity by level of Aβ-like peptides Psychogeriatrics 4: 23-27, 2004


{@@iwE]ȊwZ^[j
  1. Flores AI, Mallon B, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB: Akt mediated survival of oligodendrocytes by neuregulins. J Neurosci 20: 7622-7630, 2000


V@j@is{ȑwEw@wȁj
  1. Xie C-X, Ozawa H, Yang Y, Kawata M: Immunohistochemical study of nucleoporin p62 in the hippocampus and hypothalamus of the rat brain. NeuroReport 11: 2965-2967, 2000


  2. Yang Y, Ozawa H, Nishi M, Yuri K, Kawata M: Postnatal development of NADPH-diaphorase activity in the rat: The role of nitric oxide in the ontogeny of arginine vasopressin and oxytocin. Endocrine J 47: 601-613, 2000


  3. Kikuchi N, Urabe M Tanaka K, Hosoda T, Tatsumi H, Kariya K, Honjo H, Ozawa H, Kawata M: Effects of estrogen on basal forebrain cholinergic neurons of the rat. Adv Obst Gynecol 52: 367-371, 2000


  4. Lu H, Ozawa H, Nishi M, Ito T, Kawata M: Serotonergic neurons in the dorsal raphe nucleus that project into the medial preoptic area contain estrogen receptor β. J Neuroendocrinol 13: 839-845, 2001


  5. Iwata T, Ukimura O, Inaba M, Kojima M, Kumamoto K, Ozawa H, Kawata M, Miki T: Immunohistochemical studies on the distribution of nerve fibers in the human prostate with special reference to the anterior fibromuscular stroma. Prostate 48: 242-247, 2001


  6. Ozawa H, Miyachi M, Tsuchiya S, Morris JF, Kawata M: Annexin-1(Lipocortin-1)-immunoreactivity in the folliculo-stellate cells of rat anterior pituitary: The effect of adrenalectomy and corticosterone treatment on its subcellular distribution. J Neuroendocrinol 14: 621-628, 2001


@@iwEw@㎕wȁj
  1. Ono M, Kung MP, Hou C, Kung HF: Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimerfs disease.Nucl Med Biol 29: 633-642, 2002


  2. Ono M, Arano Y, Mukai T, Saga T, Fujioka Y, Ogawa K, Kawashima H, Konishi J, Saji H: Control of radioactivity pharmacokinetics of 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes. Bioconj Chem 13: 491-501, 2002


  3. Mukai T, Namba S, Arano Y, Ono M, Fujioka Y, Uehara T, Ogawa K, Konishi J, Saji H: Synthesis and evaluation of a monoreactive DOTA derivative for indium-111-based residualizing label to estimate protein pharmacokinetics. J Pharm Pharmacol 54: 1073-7081, 2002


  4. Ono M, Wilson A, Nobrega J, Westaway D, Verhoeff P, Zhuang ZP, Kung MP, Kung HF: 11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimerfs disease.Nucl Med Biol 30: 565-571, 2003


  5. Nakayama M, Haratake M, Ono M, Koiso T, Harada K, Nakayama H, Yahara S, Ohmomo Y, Arano Y: A new 68Ge/68Ga generator system using an organic polymer containing N-methylglucamine groups as adsorbent for 68Ge. Appl Radiat Isot 58: 9-14, 2003


  6. Nakayama M, Ono M, Haratake M: A new hydroxamamide-based ligand system for 99mTc labeling of proteins and polypeptides. Biomed Res Trace Elem 14: 29-33, 2003


@[@imSgQ҃Rj[EBQj
  1. Kato K, Inaguma Y, Ito H, Iida K, Iwamoto I, Kamei K, Ochi N, Ohta H, Kishikawa M: Ser-59 is the major phosphorylation site in αB-crystallin accumulated in the brain of patients with Alexander's disease. J Neurochem 76: 730-736, 2001


  2. Ito H, Kamei K, Iwamoto I, Inaguma Y, Nohara D, Kato K: Phosphorylation-induced change of the oligomerization state of αB-crystallin. J Biol Chem 276: 5346-5352, 2001


  3. Ueda H, Morishita R, Yamauchi J, Itoh H, Kato K, Asano T: Regulation of Rac and Cdc42 pathways by Gi during lysophosphatidic acid-induced cell spreading. J Biol Chem 276: 6846-6852, 2001


  4. Kato K, Ito H, Iwamoto I, Iida K, Inaguma Y: Protein kinase inhibitors suppress stress-induced dissociation of Hsp27. Cell Stress Chap 6: 16-20, 2001


  5. Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Kato K, Uematsu T: αB-crystallin, a low molecular weight heat shock protein, acts as a regulator of platelet function. Cell Stress Chap 6: 21-28, 2001


  6. Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M: Mutations in SIP1, encoding Smad interacting protein 1, cause a form of Hirschsprung disease. Nat Genet 27: 369-370, 2001


  7. Katoh-Semba R, Takeuchi IK, Inaguma Y, Ichisaka S, Hata Y, Tsumoto T, Iwai M, Mikoshiba K, Kato K: Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: Involvement of region-specific voltage-dependent calcium channels. J Neurochem 77: 71-83, 2001


  8. Ito H, Kamei K, Iwamoto I, Inaguma Y, Kato K: Regulation of the levels of small heat shock proteins during differentiation of C2C12 cells. Exp Cell Res 266: 213-221, 2001


  9. Kozawa O, Niwa M, Matsuno H, Ishisaki A, Kato K, Uematsu T: Stimulatory effect of basic fibroblast growth factor on induction of heat shock protein 27 in osteoblasts: Role of protein kinase C. Arch Biochem Biophys 388: 237-242, 2001


  10. Kozawa O, Otsuka T, Hatakeyama D, Niwa M, Matsuno H, Ito H, Kato K, Matsui N, Uematsu T: Mechanism of prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts. Cell Signal 13: 535-541, 2001


  11. Inaguna Y, Ito H, Iwamoto I, Saga S, Kato K: αB-crystallin phosphorylated at Ser-59 is localized in centrosomes and midbodies during mitosis. Eur J Cell Biol 80: 741-748, 2001


  12. Yamada K, Yamada Y, Nomura N, Miura K, Wakako R, Hayakawa C, Matsumoto A, Kumagai T, Yoshimura I, Miyazaki S, Kato K, Sonta S, Ono H, Yamanaka T, Nagaya M, Wakamatsu N: Nonsense and frameshift mutations in ZFHX1B, encoding smad interacting protein-1, cause a complex developmental disorder with a variety of neurocristopathies. Am J Hum Genet 69: 1178-1185, 2001


  13. Asano T, Shinohara H, Morishita R, Ueda H, Kawamura N, Katoh-Semba R, Kishikawa M, Kato K: Selective localization of G protein γ5 subunit in the subventricular zone of the lateral ventricle and rostral migratory stream of the adult rat brain. J Neurochem 79: 1129-1135, 2001


  14. Ueda H, Morishita R, Itoh H, Narumiya S, Mikoshiba K, Kato K, Asano T: Gα11 induces caspace-mediated proteolytic activation of Rho-associated kinase, ROCK-1, in HeLa cells. J Biol Chem 276: 42527-42533, 2001


  15. Bidmon H-J, Emde B, Kowalski T, Schmitt M, Mayer B, Kato K, Asayama K, Witte OW, Zilles K: Nitric oxide synthetase-I containing cortical interneurons co-express antioxidative enzymes and anti-apoptotic Bcl2 following focal ischemia: evidence for direct and indirect mechanisms towards their resistance to neuropathology. J Chem Neuroanat 22: 167-184, 2001


  16. Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Kato K, Tatematsu N, Shibata T, Uematsu T: Inhibition by adenylyl cyclase-cAMP system of ET-1-induced HSP27 in osteoblasts. Am J Physiol Endocrinol Metab 281: E1260-E1266, 2001


  17. Hotta K, Niwa M, Hara A, Ohno T, Wang X, Matsuno H, Kozawa O, Ito H, Kato K, Otsuka T, Matsui N, Uematsu T: The loss of susceptibility to apoptosis in exudated tissue neutrophils is associated with their nuclear factor-kappaB activation. Eur J Pharmacol 433: 17-27, 2001


  18. Tanabe K, Kozawa O, Niwa M, Yamomoto T, Matsuno H, Ito H, Kato K, Dohi S, Uematsu T: Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells. J Cell Biochem 84: 39-46, 2002


  19. Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Ito H, Kato K, Tatematsu N, Shibata T, Uematsu T: Upregulation by retinoic acid of transforming growth factor-beta-stimulated heat shock proten 27 induction in osteoblasts: involvement of mitogen-activated protein kinases. Biochim Biophys Acta 1589: 15-30, 2002


  20. Tokuda H, Kozawa O, Niwa M, Matsuno H, Kato K, Uematsu T: Mechanism of prostagrandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells. J Endocrinol 172: 271-281, 2002


  21. Ito H, Kamei K, Iwamoto I, Inaguma Y, Galcia-Mata R, Sztul E, Kato K: Inhibition of proteasomes induces accumulation, phosphorylation and recruitment of HSP27 and αB-crystallin to aggresomes. J Biochem 131: 593-603, 2002


  22. Katoh-Semba R, Asano T, Ueda H, Morishita R, Takeuchi IK, Inaguma Y, Kato K: Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J 16: 1328-30, 2002


  23. Kato K, Ito H, Kamei K, Iwamoto I, Inaguma Y: Innervation-dependent phosphorylation and accumulation of αB-crystallin and Hsp27 as insoluble complexes in disused muscle. FASEB J 16: 1432-1434, 2002


  24. Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Kato K, Uematsu T: Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts. J Cell Biochem 86: 357-364, 2002


  25. Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Oiso Y, Kato K, Uematsu T: HSP20, a low-molecular-weight heat shock-related protein, acts extracellularly as a regulator of platelet functions: a novel defence mechanism.Life Sci 72: 113-124, 2002


  26. Wang H, Ichihara G, Ito H, Kato K, Kitoh J, Yamada T, Yu X, Tsuboi S, Moriyama Y, Sakatani R, Kamijima M, Itohara S, Takeuchi Y: Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days. Toxicol Sci 67: 114-120, 2002


  27. Yamauchi S, Tokita Y, Aono S, Matsui F, Shuo T, Ito H, Kato K, Kasahara K, Oohira A: Phosphorylation of neuroglycan C, a brain-specific transmembrane chondroitin sulfate proteoglycan, and its localization in the lipid rafts. J Biol Chem 277: 20583-20590, 2002


  28. Hirade K, Kozawa O, Tanabe K, Niwa M, Matsuno H, Oiso Y, Akamatsu S, Ito H, Kato K, Katagiri Y, Uematsu T: Thrombin stimulates dissocoation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 283: H941-H948, 2002


  29. Ito H, Kamei K Iwamoto I, Inaguma Y, Tsuzuki M, Kishikawa M, Shimada A, Hosokawa M, Kato K: Hsp27 suppresses the formation of inclusion bodies induced by expression of R120G alphaB-crystallin, a cause of desmin-related myopathy. Cell Mol Life Sci 60: 1217-1223, 2003


  30. Tokuda H, Harada A, Hirade K, Matsuno H, Ito H, Kato K, Oiso Y, Kozawa O: Incadronate amplifies prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts: enhancement of MAP kinase activity. J Biol Chem 278: 18930-18937, 2003


  31. Niwa M, Hotta K, Kanamori Y, Hatakeyama D, Hirade K, Katayama M, Hara A, Mori H, Ito H, Kato K, Matsuno H, Uematsu T, Kozawa O: Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils. Eur J Pharmacol 466: 245-253, 2003


  32. Tokuda H, Kato K, Oiso Y, Kozawa O: Contrasting effects of triiodothyronine on heat shock protein 27 induction and vascular endothelial growth factor synthesis stimulated by TGF-beta in osteoblasts. Mol Cell Endocrinol201: 33-38, 2003


  33. Wang X, Tokuda H, Hatakeyama D, Hirade K, Niwa M, Ito H, Kato K, Kozawa O: Mechanism of simvastatin on induction of heat shock protein in osteoblasts. Arch Biochem Biophys 415: 6-13, 2003


  34. Tokuda H, Niwa M, Ito H, Oiso Y, Kato K, Kozawa O: Involvement of stress-activated protein kinase/c-Jun N-terminal kinase in endothelin-1-induced heat shock protein 27 in osteoblasts.Eur J Endocrinol 149: 239-245, 2003


  35. Wang H, Ichihara G, Ito H, Kato K, Kitoh J, Yamada T, Yu X, Tsuboi S, Moriyama Y, Takeuchi Y: Dose-dependent biochemical changes in rat central nervous system after 12-week exposure to 1-bromopropane. Neurotoxicology 24: 199-206, 2003


  36. Kim H-C, Yamada K, Nitta A, Olariu A, Tran MH, Mizuno M, Nakajima A, Nagai T, Kamei H, Jhoo W-K, Im D-H, Shin E-J, Hjelle OP, Ottersen OP, Park SC, Kato K, Mirault M-E, Nabeshima T: Immunocytochemical evidence that amyroid β (1-42) impairs endogenous antioxidant systems in vivo. Neuroscience 119: 399-419, 2003


  37. Niwa M, Hotta K, Ito H, Kato K, Matsuo H, Uematsu T, Kozawa O: Involvement of p38 mitogen-activated protein kinase in heat shock protein 27 induction in human neutrophils. Eur J Pharmacol 466: 245-253, 2003


@qK@@iwEw@wnȁj
  1. Rikimaru K, Mori K, Kan T, Fukuyama T: Synthetic studies on (-)-lemonomycin: stereocontrolled construction of the 3,8-diazabicyclo[3.2.1] skeleton. Chem Commun (3): 394-396, 2005


  2. Kan T, Hosokawa S, Nara S, Tamiya H, Shirahama H, Matsuda F: Acetoxy group directed cyclization promoted by SmI2: directing group determined stereocomplementarity. J Org Chem 69: 8956-8958, 2004


  3. Kurosawa W, Kobayashi H, Kan T, Fukuyama T: Total synthesis of (-)-ephedradine A (orantine): An efficient construction of optically active dihydrobenzofuran-ring via C-H insertion reaction.Tetrahedron Lett 60: 9615, 2004


  4. Mori K, Rikimaru K, Kan T, Fukuyama T: Synthetic studies on (+)-naphthyridinomycin: stereoselective synthesis of the tetracyclic core framework. Org Lett 6: 3095-3097, 2004


  5. Kan T, Fujimoto T, Asoh Y, Ieda S, Kitaoka H, Fukuyama T: Stereocontrolled total synthesis of potent immunosuppressant FR901483. Org Lett 6: 2729-2731, 2004


  6. Tohma S, Rikimaru K, Endo A, Shimamoto K, Kan T, Fukuyama T: Stereoselective nucleophilic addition reaction with a new chiral template and its application to synthesis of optically active α-arylglycine derivatives.Synthesis 909: 2004


  7. Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H: Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of w-azide pentaphenyl ester: synthesis and biological evaluation of LY411575 analogues.Tetrahedron Lett45: 2323, 2004


  8. Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity. Bioorg Med Chem Lett 14: 1983-1985, 2004


  9. Kan T, Fukuyama T: Strategies Ns: A highly versatile synthetic method for amines.Chem Commun (4): 353-359, 2004


  10. Rikimaru K, Yanagisawa A, Kan T, Fukuyama T: A versatile synthesis of α-amino acid derivatives via the Ugi four-component condensation with a novel convertible isonitrile.Synlett 41: 2004


  11. Kan T: Total synthesis of potent antitumor alkaloid ecteinascidin 743. J Syn Org Chem Jpn 61: 949, 2003


  12. Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: Highly efficient incorporation of biotin-tag and cross-linking group.Chem Commun 17: 2244-2245, 2003


  13. Kurosawa W, Kan T, Fukuyama T: Stereocontrolled total synthesis of (-)-ephedradine A (orantine). J Am Chem Soc 125: 8112-8113, 2003


  14. Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide is a non-competitive γ-secretase inhibitor that preferentially reduces Aβ42 generation.J Biol Chem 278: 18664-18870, 2003


  15. Kurosawa W, Kan T, Fukuyama T: An efficient synthesis of optically active trans-2-aryl- 2,3-dihydrobenzofuran-3-carboxylic acid esters via C-H insertion reaction.Synlett 1028: 2003


ݓc@@iLw, w@㎕wȁj
  1. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A: Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3β-dependent phosphorylation of β-catenin and downregulates β-catenin. J Biol Chem 275: 34399-34406, 2000


  2. Kadoya T, Kishida S, Fukui A, Hinoi T, Michiue T, Asashima M, Kikuchi A: Inhibition of Wnt signaling pathway by a novel axin-binding protein. J Biol Chem 275: 37030-37037, 2000


  3. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S-I, Michiue T, Takada S, Asashima M, Kikuchi A: A novel β-catenin-binding protein inhibits β-catenin-dependent Tcf activation and axis formation. J Biol Chem 275: 32871-32878, 2000


  4. Hino S-I, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A: Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein. Mol Cell Biol 21: 330-342, 2001


  5. Kishida M, Hino S-I, Michiue T, Yamamoto H, Kishida S, Fukui A, Asashima M, Kikuchi A: Synergistic activation of the Wnt signaling pathway by Dvl and casein kinase Iε. J Biol Chem 276: 33147-33155, 2001


  6. Kobayashi M, Kishida S, Fukui A, Michiue T, Miyamoto Y, Okamoto T, Yoneda Y, Asashima M, Kikuchi A: Nuclear localization of Duplin, a β-catenin-binding protein, is essential for its inhibitory activity on the Wnt signaling pathway. J Biol Chem 277: 5816-5822, 2002


ؑ\@ǖ@isȑwEwj
  1. Kiso Y, Kasai S, Shuto D, Liu P, Rajesh S, Kotake T, Hidaka K, Hamada T, Shibakawa S, Kimura T, Hayashi Y: Design and synthesis of substrate-based β-secretase inhibitors. Biopolymers 71: 290, 2003


  2. Shuto D, Kasai S, Kimura T, Liu P, Hidaka K, Hamada T, Shibakawa S, Hayashi Y, Hattori C, Szabo B, Ishiura, S, Kiso Y: KMI-008, a novel β-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides. Bioorg Med Chem Lett 13: 4273-4276, 2003


  3. Sohma Y, Sasaki M, Hayashi Y, Kimura T, Kiso Y: Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides. Chem Commun 1: 124-125, 2004


  4. Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido CT, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004


  5. Sohma Y, Sasaki M, Hayashi Y, Kimura T, Kiso Y: Design and synthesis of a novel water-soluble Aβ1-42 isopeptide: an efficient strategy for the preparation of Alzheimerfs disease-related peptide, Aβ1-42, via O-N intramolecular acyl migration reaction. Tetrahedron Lett 45: 5965-5968, 2004


  6. Sohma Y, Hayshi Y, Skwarczynski M, Hamada Y, Sasaki M, Kimura T, Kiso Y: O-N Intramolecular acyl migration reaction in the development of prodrugs and the synthesis of difficult sequence-containing bioactive peptides. Biopolym Pept Sci 76: 344-356, 2004


  7. Kimura T, Shuto D, Hamada Y, Igawa N, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Kiso Y: Design and synthesis of highly active Alzheimerfs β-secretase (BACE1) inhibitors, KMI-420 and KMI-429, with enhanced chemical stability. Bioorg Med Chem Lett 15: 211-215, 2005


  8. Sohma Y, Hayashi Y, Kimura M, Chiyomori Y, Taniguchi A, Sasaki M, Kimura T, Kiso Y: The eO-acyl isopeptide methodf for the synthesis of difficult sequence-containing peptides: application to the synthesis of Alzheimerfs disease-related amyloid β-peptide (Aβ) 1-42. J Pept Sci 11: 441-451, 2005


  9. Sohma Y, Chiyomori Y, Kimura M, Fukao F, Taniguchi A, Hayashi Y, Kimura T, Kiso Y: O-Acyl isopeptide method for the efficient preparation of amyloid β peptide (Aβ) 1-42 mutants. Bioorg Med Chem 13: 6167-6174, 2005


؉@ʉh@isww@Ewȁj
  1. Von Arnim CA, Tangredi MM, Peltan ID, Lee BM, Irizarry MC, Kinoshita A, Hyman BT: Demonstration of BACE phosphorylation and its interaction with GGA1 in cells by fluorescence lifetime imaging microscopy. J Cell Sci 117: 5437-5445, 2004


  2. Ihara M, Kinoshita A, Yamada S, Tanaka H, Tanigaki A, Kitano A, Goto M, Okubo K, Nishiyama H, Ogawa O, Takahashi C, Itohara S, Nishimune Y, Noda M, Kinoshita M: Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell 8: 343-352, 2005


  3. Von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT: The low density lipoprotein receptor-related protein (LRP) is a novel β-secretase (BACE1) substrate. J Biol Chem 280: 17777-17785, 2005


O}@O@iȎȑwEw@㎕wȁj
  1. Matsuda Y, Saegusa H, Zong S, Noda T, Tanabe T: Mice lacking Cav2.3 (α1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun289: 791-795, 2001


  2. Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Analysis of Ca2+ currents in spermatocytes from mice lacking Cav2.3 (α 1E) Ca2+ channel. Biochem Biophys Res Commun288: 1032-1036, 2001


  3. Saegusa H, Kurihara T, Zong S, Kazuno A, Matsuda Y, Nonaka T, Han W, Toriyama H, Tanabe T: Suppression of inflammatory and neuropathic pain symptoms in mice lacking N-type Ca2+ channel. EMBO J 20: 2349-2356. 2001


  4. Kubota M, Murakoshi T, Saegusa H, Kazuno A, Zong S, Hu Q, Noda T, Tanabe T: Intact LTP and fear memory but impaired spatial memory in mice lacking Cav2.3 (α 1E) channel. Biochem Biophys Res Commun 282: 242-248. 2001


  5. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Increased sensitivity to halothane but decreased sensitivity to propofol in mice lacking the N-type Ca2+ channel. Neurosci Lett 350: 41-45, 2003


  6. Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Cav2.3) Ca2+ channel. Anesth Analg 97: 96-103, 2003


@p@iswEw@wȁj
  1. Takada Y, Sato EF, Nakajima T, Hosono M, Tsumura M, Inoue M, Yamada R: Granulocyte-colony stimulating factor enhances antitumor effect of hyperthermia. J Hyperthermia 16: 275-286, 2000


  2. Goto T, Kono T, Ishii M, Sato EF: Supressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by TNF-α. J Invest Dermatol 115: 986-989, 2000


  3. Nakamura A, Park AM, Nagata K, Sato EF, Tamura T, Inoue M: Oxidative cellular damage associated with transformation of Helicobacter pylori from a bacillary to a coccoid form. Free Radic Biol Med 28: 1611-1618, 2000


  4. Inoue M, Nishikawa M, Sato EF, Paku A, Kashiba M, Takehara Y, Utsumi K: Cross-talk between NO and oxyradicals, a supersystem that regulates energy metabolism and survival of animals. Free Radic Res 33: 757-770, 2000


  5. Tsuchiya M, Asada A, Maeda K, Ueda Y, Sato EF, Shindo M, Inoue M: Propofol versus midazolam regarding their antioxidant activities. Am J Respir Crit Care Med 163: 1-6, 2001


  6. Tomita M, Sato EF, Nishikawa M, Yamano Y, Inoue M: Nitric oxide regulates mitochondrial respiration and functions of articular chondrocytes. Arthritis Rheum 44: 96-104, 2001


  7. Nishikawa M, Nishiguchi S, Tamori A, Koh N, Takeda T, Shiomi S, Kubo S, Hirohashi K, Kinoshita H, Sato EF, Inoue M: Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma. Cancer Res 115: 1843-1845, 2001


  8. Nishikawa M, Nagatomi H, Bao-Jun Chang, Sato EF, Inoue M: Targeting superoxide dismutase to renal proximal tuble cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin. Arch Biochem Biophys 387: 78-84, 2001


  9. Nishikimi A, Kira Y, Kasahara E, Sato EF, Kanno T, Utsumi K, Inoue M: Tributyltin interacts with thiol groups in adenine nucleotide translocator therby inducing cytochrome c release. Biochem J 356: 621-626, 2001


  10. Nishikawa M, Nagatomi H, Nishijima M, Ohira G, Chang BJ, Sato E, Inoue M: Targeting superoxide dismutase to renal proximal tubule cells inhibits nephrotoxicity of cisplatin and increases the survival of cancer-bearing mice. Cancer Lett 171: 133-138, 2001


  11. Wang Y, Kashiba M, Kasahara M, Tsuchiya M, Sato EF, Utsumi K, Inoue M: Metabolic cooperation of ascorbic acid and glutathione in normal and vitamin C-deficient ODS rats. Physiol Chem Phys Med NMR 33: 29-39, 2001


  12. Nishikimi A, Matsukawa T, Hoshino K, Ikeda S, Kira Y, Sato EF, Inoue M, Yamada M: Localization of nitric oxide synthase activity in mouse unfertilized oocytes and fertilized embryos during preimplantation development. Reproduction 122: 957-63, 2001


  13. Kira Y, Sato EF, Inoue M: Association of Cu,Zn-SOD with membrane of mitochondria amd peroxisomes. Arch Biochem Biophys 399: 96-102, 2002


  14. Tsuchiya M, Asada A, Kasahara E, Sato EF, Shindo M, Inoue M: Antioxidant protection of propfol and its recycling in erythrocyte membrane. Am J Respir Crit Care Med 165: 54-60, 2002


  15. Kasahara E, Sato EF, Miyoshi M, Konaka R, Hiramoto K, Sasaki J, Tokuda M, Nakano Y, Inoue M: Oxidative stress underlies the pathogenesis of testicular atrophy induced by di(2-ethylhexyl)phthalate. Biochem J 365: 1-8, 2002


  16. Chang BJ, Nishikawa M, Sato EF, Inoue M: L-carnitine inhibits cisplatin-induced inhury of the kidney and small intestine Arch Biochem Biophys 405: 55-64, 2002


_@r@iswEwȁj
  1. Kume T, Nishikawa H, Tomioka H, Katsuki H, Akaike A, Kaneko S, Maeda T, Kihara T, Shimohama S: p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures. Brain Res 852: 279-289, 2000


  2. Kageyama T, Oeda T, Imura H, Kawamata J, Suzuki S, Tomimoto H, Shimohama S: Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes. Neurology 54: 265-266, 2000


  3. Yamamoto K, Hashimoto K, Isomura Y, Shimohama S, Kato N: An IP3-assisted form of Ca2+- induced Ca2+ release in neocortical neurons. NeuroReport 11: 535-539, 2000


  4. Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S: Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J Neurochem 74: 1175-1184, 2000


  5. Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S: Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 60: 321-327, 2000


  6. Sawada H, Ibi M, Kihara T, Urushitani M, Honda A, Akaike A, Shimohama S: Mechanisms of antiapoptotic effects of estrogen in nigral dopaminergic neurons.FASEB J 14: 1202-1214, 2000


  7. Tanino H, Shimohama S, Sasaki Y, Sumida Y, Fujimoto S: Increase in phospholipase C-δ1 protein levels in aluminum-treated rat brains. Biochem Biophys Res Commun 271: 620-625, 2000


  8. Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S: Activation of NADPH oxidase in Alzheimerfs disease brains. Biochem Biophys Res Commun 273: 5-9, 2000


  9. Urushitani M, Inoue R, Nakamizo T, Honda K, Kihara T, Sawada H, Akaike A, Shibasaki H, Shimohama S: Neuroprotective effect of cyclic GMP against radical- induced toxicity in cultured spinal motor neurons. J Neurosci Res 61: 443-448, 2000


  10. Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M, Tsuruo T, Minato N, Shimohama S: The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res 879: 115-121, 2000


  11. Imura T, Shimohama S: Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia. J Neurosci Res 62: 539-546, 2000


  12. Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S: Protection of motor neurons by estradiol. NeuroReport 11: 3493-3497, 2000


  13. Kageyama T, Imura T, Matsuo A, Minato N, Shimohama S: Distribution of the 4F2 light chain, LAT1, in the mouse brain. NeuroReport 11: 3663-3666, 2000


  14. Kim HT, Russell RL, Raina AK, Harris PLR, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G: Protein disulfide isomerase in Alzheimer disease. Antioxid Redox Signal 2: 485-489, 2000


  15. Kitamura H, Shimohama S, Akaike A, Taniguchi T: The parkinsonian models: invertebrates to mammals. Jpn J Pharmacol 84: 237-243, 2000


  16. Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ: Bip/GRP78-induced production of cytokines and uptake of amyloid-β (1-42) peptide in microglia. Biochem Biophys Res Commun 281: 6-10, 2001


  17. Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S: N-methyl-D-apartate receptor-mediated mitochondrial Ca2+ overload in acute excitotoxic motor neurons death: A mechanism distinct from chronic neurotoxicity after Ca2+ influx. J Neurosci Res 63: 377-387, 2001


  18. Shimohama S, Kihara T: Nicotinic receptor-mediated protection against beta amyloid neurotoxicity. Biol Psychiat 49: 233-239, 2001


  19. Kitamura Y, Sanada H, Kakimura J, Ishida Y, Shimohama S, Taniguchi T: Decrease of tyrosine hydroxylase-α-synuclein- and parkin-expressing neurons in the substantia nigra of MPTP-treated C57BL/6N mice. Biog Amines 16: 127-136, 2001


  20. Kitamura Y, Ishida Y, Takata K, Kakimura J, Mizutani H, Shimohama S, Akaike A, Taniguchi T: α-Synuclein proteins is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Res 898: 181-185, 2001


  21. Kageyama T, Kawamata J, Shimohama S: Coexistence of two different type I repeats. Arch Neurol 58: 1022, 2001


  22. Ibi M, Sawada H, Nakanishi M, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A: Protective effects of 1α,25-(OH)2D3 against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40: 761-771, 2001


  23. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: Alpha7 nicotinic receptor transduces signals to PI3 kinase to block Aβ-induced neurotoxicity. J Biol Chem 276: 13541-13546, 2001


  24. Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A: Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J Neurosci Res 64: 466-475, 2001


  25. Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PLR, Jones PK, Petersen RB, Perry G, Smith MA: Mitochondrial abnormalities in Alzheimer disease. J Neurosci 21: 3017-3023, 2001


  26. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60: 759-767, 2001


  27. Oeda T, Shimohama S, Kitagawa N, Kohno R, Imura T, Shibasaki H, Ishii N: Oxidative stress causes abnormal accumulation of familial amyotrophic lateral sclerosis-related mutant SOD1 in transgenic C. elegans. Hum Mol Genet 10: 2013-2023, 2001


  28. Zhu X, Rottkamp CA, Hartzler A, Sun Z, Takeda A, Boux H, Shimohama S, Perry G, Smith MA: Activation of MKK6, an upstream activator of p38, in Alzheimerfs disease. J Neurochem 79: 311-318, 2001


  29. Tanino H, Kusuda T, Kishimoto A, Shimohama S, Fujimoto S: Alterations of phospholipase C isozymes in rat cerebral cortex through hyperoxia. Biol Pharm Bull 24: 1241-1245, 2001


  30. Shimohama S, Tanino H, Fujimoto S: Differential subcellular localization of caspase family proteins in the adult rat brain. Neurosci Lett 315: 125-128, 2001


  31. Shimohama S, Tanino H, Fujimoto S: Differential expression of rat brain caspase family proteins during development and aging. Biochem Biophys Res Commun 289: 1063-1066, 2001


  32. Tsuji T, Shimohama S: Analysis of the proteomic profiling of brain tissue in Alzheimerfs disease. Dis Markers 17: 247-257, 2001


  33. Yamamoto K, Hashimoto K, Nakano M, Shimohama S, Kato N: A distinct form of calcium release down-regulates membrane excitability neocortical pyramidal cells. Neuroscience 109: 665-676, 2002


  34. Yamamoto K, Nakano M, Hashimoto K, Shimohama S, Kato N: Emergence of a functional coupling between insotol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical pyramidal neurons. Neuroscience 109: 677-685, 2002


  35. Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA: Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies. Neurosci Lett 319: 25-28, 2002


  36. Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PLR, Shimohama S, Szweda LI, Kaminski MA, Price DL, Cleveland DW, Sayre LM, Perry G: High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem 277: 4644-4648, 2002


  37. Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, Kaneko S, Akaike A: Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proc Nat Acad Sci USA 99: 3288-3293, 2002


  38. Kakimura J-I, Kitamura Y, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J 16: 601-603, 2002


  39. Kawamata J, Shimohama S: Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimerfs disease. J Alz Dis 4: 71-76, 2002


  40. Sawada H, Ibi M, Kihara T, Honda K, Nakanishi M, Sakka N, Akaike A, Shimohama S: Estradiol protects dopaminergic neurons in a MPP+ Parkinsonfs disease model. Neuropharmacology 42: 1056-1064, 2002


  41. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A: Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. J Neurosci Res 70: 274-282, 2002


  42. Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S: Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurosci Lett 333: 25-28, 2002


  43. Tsuji T, Shiozaki A, Kohno R, Yoshizato K, Shimohama S: Proteomic profiling and neurodegeneration in Alzheimerfs disease. Neurochem Res 27: 1245-1253, 2002


  44. Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Possible involvement of ER chaperone GRP78 on reduced formation of amyloid-β deposits. Ann NY Acad Sci 977: 327-332, 2002


  45. Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Possible protective mechanisms of heme oxygenase-1 in the brain. Ann NY Acad Sci 977: 501-506, 2002


  46. Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Akiev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA: Reactive oxygen: its sources and significance in Alzheimer disease. J Neural Transm Suppl 62: 69-75, 2002


  47. Perry G, Taddeo M, Nunomura A, Zhu X, Zenteno-Savin T, Drew K, Shimohama S, Avila J, Castellani RJ, Smith MA: Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comp Biochem Physiol C Toxicol Pharmacol 133: 507-513, 2002


  48. Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S: Phosphodiesterase (PDE) inhibitors are neuroprotective to cultured motor neurons. J Neurosci Res 71: 485-495, 2003


  49. Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S: Hyperbilirubinemia protects against focal ischemia in rats. J Neurosci Res 71: 544-550, 2003


  50. Takata K, Kitamura Y, Kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S: Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis. Biochem Biophys Res Commun 301: 699-703, 2003


  51. Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishi N: The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. J Biol Chem 278: 12130-12134, 2003


  52. Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S: Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-β (1-42) in rat microglia. J Pharmacol Sci 92: 115-123, 2003


  53. Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shimohama S: Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. J Neurosci Res 73: 166-175, 2003


  54. Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A: Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone. NeuroReport 14: 2425-2428, 2003


  55. Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S: Possible involvement of Wiskott-Aldrich syndrome protein (WASP) family in aberrant neuronal sprouting in Alzheimer,s disease. Neurosci Lett 346: 149-152, 2003


  56. Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H, Shimohama S: Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone. Biog Amines 17: 281-291, 2003


  57. Kitamura Y, Inden M, Sanada H, Takata K, Taniguchi T, Shimohama S, Orii H, Mochii M, Agata K, Watanabe K: Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model. J Pharmacol Sci 92: 137-142, 2003


  58. Takata K, Kitamura Y, Umeki M, Tsuchiya D, Kakimura J, Taniguchi T, Gebicke-Haerter PJ, Shimohama S: Possible involvement of small oligomers of amyloid-β peptides in 15-deoxy-δ12,14 prostaglandin J2-sensitive microglial activation. J Pharmacol Sci 91: 330-333, 2003


  59. Hitomi T, Mezaki T, Tsujii T, Kinoshita M, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H: Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy. J Neurol Neurosurg Psychiat 74: 373-375, 2003


  60. Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S: Heat shock protein-90-induced microglial clearance of exogenous amyloid- beta1-42 in rat hippocampus in vivo. Neurosci Lett 344: 87-90, 2003


  61. Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S: Presenilin 1 is involved in the maturation and trafficking of N-cadherin to the plasma membrane. J Neurosci Res 74: 184-191, 2003


  62. Nagasawa K, Tanino H, Shimohama S, Fujimoto S: Effects of hypoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Life Sci 73: 1453-1462, 2003


  63. Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y: Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochem Res 28: 1035-1040, 2003


  64. Sawada H, Shimohama S: Estrogens and Parkinsonfs disease: Novel approach for neuroprotection. Endocrine 21: 77-80, 2003


  65. Raina AK, Zhu X, Shimohama S, Perry G, Smith MA: Tipping the apoptotic balance in Alzheimer disease: The abortosis concept. Cell Biochem Biophys 39: 249-255, 2003


  66. Raine AK, Hochman A, Ickes H, Zhu X, Ogawa O, Cash AD, Shimohama S, Perry G, Smith MA: Apptotic promoters and inhibitors in Alzheimerfs disease: Who wins out? Prog Neuropsychopharmacol Biol Psychiat 27: 251-254, 2003


  67. Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S: Proteasome mediates dopaminergic neuronal degeneration and its inhibition causes a-synuclein inclusions. J Biol Chem 279: 10710-10719, 2004


  68. Shiozaki A, Tsuji T, Kohno R, Kawamata J, Uemura K, Teraoka H, Shimohama S: Proteome analysis of brain proteins in Alzheimerfs disease: Subproteomics following sequentially extracted protein preparation. J Alz Dis 6: 257-268, 2004


  69. Kanki R, Nakamizo T, Kihara T, Yamashita H, Sawada H, Kawamata J, Uemura K, Shibasaki H, Akaike A, Shimohama S: Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons. Brain Res 1015: 73-81, 2004


  70. Kohno R, Sawada H, Kawamoto Y, Uemura K, Shibasaki H, Shimohama S: BDNF is induced by wild-type a-synuclein but not by the two mutants, A30P or A53T, in glioma cell line. Biochem Biophys Res Commun 318: 113-118, 2004


  71. Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA: Neuroprotective properties of Bcl-w in Alzheimer disease. J Neurochem 89:  1233-1240, 2004


  72. Nagasawa K, Aoki H, Yasuda E, Nagai K, Shimohama S, Fujimoto S: Possible involvement of group I mGluRs in neuroprotective effect of thenine. Biochem Biophys Res Commun 320: 116-122, 2004


  73. Takatra K, Kitamura Y, Shibagaki K, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S: High mobility group box protein-1 inhibits microglial Aβ clearance and enhances Aβ neurotoxicity. J Neurosci Res 78: 880-891, 2004


  74. Shibasaki H, Hitomi T, Mezaki T, Terai H, Kihara T, Kageyama T, Murase N, Matsuhashi M, Tomimoto H, Ikeda A, Shimohama S, Ito M, Oka N: Sensory ataxia with arthrogryposis multiplex congenita in siblings. A new form of congenital proprioceptive sensory ganglionopathy. J Neurol 251: 1340-1344, 2004


  75. Nagasawa K, Nishida K, Nagai K, Shimohama S, Fujimoto S: Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite. Neurosci Lett 367: 246-249, 2004


  76. Inden M, Kim D, Gu Y, Kitamura Y, Kondo J, Tsuchiya D, Taniguchi T, Shimohama S, Akaike A, Sumi S, Inoue K: Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons. J Pharmacol Sci 96: 53-64, 2004


  77. Kihara T, Sawada H, Nakamizo T, Kanki R, Yamashita H, Maelicke A, Shimohama S: Galantamine modulates nicotinic receptor and blocks Aβ-enhanced glutamate toxicity. Biochem Biophys Res Commun 325: 976-982, 2004


  78. Nakamizo T, Kawamata J, Yamashita H, Kanki R,Kihara T, Sawada H,Fujisawa H, Akaike A, Shimohama S:  Stimulation of nicotinic acetylcholine receptors protects motor neurons. Biochem Biophys Res Commun 330:  1285-1289, 2005


  79. Sawada H, Yamakawa K, Yamakado H, Hosokawa R, Ohba M, Miyamoto K, Kawamura T, Shimohama S: Cocaine and phenylephrine eye drop test for Parkinson disease. J Am Med Assoc 293: 932-934, 2005


  80. Liu Q, Smith MA, Avila J, Debernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PL, Sayre LM, Perry G: Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations. Free Radic Biol Med 38: 746-754, 2005


  81. Izumi Y, Sawada H, Sakka N, Yamamoto N, Kume T, Katsuki H, Shimohama S, Akaike A: p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly. J Neurosci Res 79: 849-860, 2005


  82. Inden M, Kondo J, Kitamura Y, Takata K, Nishimura K, Taniguchi T, Sawada H, Shimohama S: Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats. J Pharmacol Sci 97: 203-211, 2005


  83. Kitamura Y, Yanagisawa D, Inden M, Takata K, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S: Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. J Pharmacol Sci 97: 289-293, 2005


  84. Kume T, Kawai Y, Yoshida K, Nakamizo T, Kanki R, Sawada H, Katsuki H, Shimohama S, Sugimoto H, Akaike A:  Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. Neurosci Lett 383: 199-202, 2005


h@_@ikwEw@wnȁj
  1. Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, Itoh M, Shin R-W, Trojanowski JQ, Sasaki H: Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 162: 247-256, 2000


  2. Yamamoto A, Shin R-W, Hasegawa K, Naiki H, Sato Hiroyuki, Yoshimasu Y, Kitamoto T: Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimerfs disease. J Neurochem 82: 1137-1147, 2002


  3. Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, Kitamoto N, Itohara S, Kasai N, Katuski M, Higuchi J, Muramoto T, Shin R-W: Follicular dentritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem Biophys Res Commun 294: 280-286, 2002


  4. Kuazi DA, Kito K, Abe Y, Shin R-W, Kamitani T, Ueda N: NEDD8 involvement in the ubiquitinated inclusion bodies. J Pathol 199: 259-266, 2003


  5. Shin RW, Kruck TP, Murayama H, Kitamoto T: A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimerfs disease. Brain Res 961: 139-146, 2003


؁@@ikCwEw@wȁj
  1. Tomita S, Fujita T, Kirino Y, Suzuki T: PDZ domain-dependent suppression of NF-κB/p65-induced Aβ42 production by a neuron specific X11-like protein. J Biol Chem 275: 13056-13060, 2000


  2. Lee D-S, Tomita S, Kirino Y, Suzuki T: Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem 275: 23134-23138, 2000


  3. Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T: Neuron-specific phosphorylation of Alzheimerfs β-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem 75: 1085-1091, 2000


  4. Yagi Y, Tomita S, Nakamura M, Suzuki T: Over-expression of human amyloid precursor protein in Drosophila. Mol Cell Biol Res Commun 4: 43-49, 2000


  5. Nakaya T, Kawahara S, Watanabe S, Lee D-S, Suzuki T, Kirino Y: Expression and function of a novel gene in odor-taste associative learning in the terrestrial slug. Genes Cells 6: 43-56, 2001


  6. Satoh Y, Hirakura Y, Shibayama S, Hirashima N, Suzuki T, Kirino Y: β-amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray. Neuosci Lett 302: 97-100, 2001


  7. Ando K, Iijima K, Elliott JI, Kirino Y, Suzuki T: Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid. J Biol Chem 276: 40353-40361, 2001


  8. Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem 277: 12915-12920, 2000


  9. Hase M, Yagi Y, Taru H, Tomita S, Sumioka A, Hori K, Miyamoto K, Sasamura T, Nakamura M, Matsuno K, Suzuki T: Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem 81: 1223-1232, 2000


  10. Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T: Interaction of APP family protein with scaffold proteins of the JNK signaling cascade. J Biol Chem 277: 20070-20078, 2000


  11. Taru H, Kirino Y, Suzuki T: Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem277: 27567-27574, 2000


  12. Ishii J, Adachi H, Aoki J, Koizumi H, Tomita S, Suzuki T, Tsujimoto M, Inoue K, Arai H: SREC-II, a new member of the scavenger receptor type F family, tans-interacts with SREC-I through its extracellular domain. J Biol Chem277: 39696-39702, 2000


  13. Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N: A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278: 22946-22955, 2003


  14. Sumioka A, Imoto S, Martins RN, Kirino Y, Suzuki T: XB51 isoforms mediate Alzheimerfs β-amyloid peptide production by X11L-dependent and -independent mechanisms. Biochem J 374: 261-268, 2003


  15. Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein mediated stabilization of amyloid β-protein precursor metabolism.J Biol Chem278: 49448-49458, 2003


  16. Sawamura N, Mihee K, Wenxin Y, Zou K, Handa K, Suzuki T, Gong J-S, Yanagisawa K, Michikawa M: Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem 279: 11984-11991, 2004


  17. Taru H, Suzuki T: Facilitation of stress-induced phosphorylation of β-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem 279: 21628-21636, 2004


  18. Tabuchi A, Ishii A, Fukuchi M, Kobayashi S, Suzuki T, Tsuda M:Activity-dependent increase in β-amyloid precursor protein mRNA expression in neurons. NeuroReport15: 1329-1333, 2004


  19. Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T: Coordinated metabolism of Alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation. J Biol Chem 279: 24343-24354, 2004


  20. Taru H, Yoshikawa K, Suzuki T: Caspase cleavage of β-amyloid precursor protein is regulated by cytoplasmic phosphorylation. FEBS Lett567: 248-252, 2004


  21. Von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U: The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J Cell Sci117: 4435-4448, 2004


  22. Asaumi M, Iijima K, Sumioka A, Iijima-Ando K, Kirino Y, Nakaya T, Suzuki T: Interaction of N-terminal acetyltransferase with the cytoplasmic domain of β-amyloid precursor protein and its effect on Aβ secretion. J Biochem 137: 147-155, 2005


Z{@p@iBwE̖hwj
  1. Shiose A, Sumimoto H: Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase. J Biol Chem 275: 13793-13801, 2000


  2. Takeya R, Takeshige K, Sumimoto H: Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Biochem Biophys Res Commun 267: 149-155, 2000


  3. Tanaka H, Takeya R, Sumimoto H: A novel intracellular membrane-bound calcium-independent phospholipase A2. Biochem Biophys Res Commun 272: 320-326, 2000


  4. Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H: A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276: 1417-1423, 2001


  5. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H: Human homologues of the Caenorhabditis eleganscell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6: 107-119, 2001


  6. Hiroaki H, Ago T, Ito T, Sumimoto H, Kohda D: Solution structure of the PX domain, a target of the SH3 domain. Nat Struct Biol 8: 526-530, 2001


  7. Nosaka Y, Arai A, Kanda E, Akasaki T, Sumimoto H, Miyasaka N, Miura O: Rac is activated by tumor necrosis factor α and is involved in activation of Erk. Biochem Biophys Res Commun 285: 675-679, 2001


  8. Ito T, Matsui Y, Ago T, Ota K, Sumimoto H: Novel modular domain PB1 recognizes PC motif to mediate functional protein-protein interactions. EMBO J 20: 3938-3946, 2001


  9. Terasawa H, Noda Y, Ito T, Hatanaka H, Ichikawa S, Ogura K, Sumimoto H, Inagaki F: Structure and ligand recognition of the PB1 domain: a novel protein module capable of binding PC motif-containing protein. EMBO J 20: 3947-3956, 2001


  10. Ago T, Takeya R, Hiroaki H, Kuribayashi F, Ito T, Kohda D, Sumimoto H: The PX domain as a novel phosphoinositide-binding module. Biochem Biophys Res Commun 287: 733-738, 2001


  11. Yamamori T, Inanami O, Sumimoto H, Akasaki T, Nagahata H, Kuwabara M: Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils. Biochem Biophys Res Commun 293: 1571-1578, 2000


  12. Kami K, Takeya R, Sumimoto H, Kohda D: Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67phox, Grb2 and Pex13p. EMBO J 21: 4268-4276, 2000


  13. Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M: A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci 22: 8504-8513, 2000


  14. Kuribayashi F, Nunoi H, Wakamatsu K, Tsunawaki S, Sato K, Ito T, Sumimoto H: The adaptor protein p40phox as a positive regulator of the superoxide-producing phagocyte oxidase. EMBO J 21: 6312-6320, 2000


  15. Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H: PAR3β, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. Biochem Biophys Res Commun 299: 641-646, 2000


  16. Ago T, Kuribayashi F, Hiroaki H, Takeya R, Ito T, Kohda D, Sumimoto H: Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation. Proc Natl Acad Sci USA 100: 4474-4479, 2003


  17. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, Nunoi H, Sumimoto H: Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem 278: 25234-25246, 2003


  18. Inoguchi T, Tsubouchi H, Etoh T, Kakimoto M, Sonta T, Utsumi H, Sumimoto H, Yu HY, Sonoda N, Inuo M, Sato N, Sekiguchi N, Kobayashi K, Nawata H: A possible target of antioxidative therapy for diabetic vascular complications-vascular NAD(P)H oxidase. Curr Med Chem10: 1759-1764, 2003


  19. Yuzawa S, Suzuki NN, Fujioka Y, Ogura K, Sumimoto H, Inagaki F: Crystallization and preliminary crystallographic analysis of autoinhibited form of tandem SH3 domain of p47phox. Acta Crystallogr D Biol Crystallogr 59: 1479-1480, 2003


  20. Etoh T, Inoguchi T, Kakimoto M, Sonoda N, Kobayashi K, Kuroda J, Sumimoto H, Nawata H: Increased expression of NAD(P)H oxidase subunits, NOX4 and p22phox, in kidney of streptozotocin-induced diabetic rats and its reversibility in interventive insulin treatment. Diabetologia 46: 1428-1437, 2003


  21. Takeya R, Sumimoto H: Fhos, a mammalian formin, directly binds to F-actin via the N-terminal region and forms a homotypic complex via the FH2 domain to promote actin fiber formation. J Cell Sci 116: 4567-4575, 2003


  22. Yoshinaga S, Kohjima M, Ogura K, Yokochi M, Takeya R, Ito T, Sumimoto H, Inagaki F: The PB1 domain and the PC motif-containing region are structurally similar protein binding modules. EMBO J 22: 4888-4897, 2003


  23. Noda Y, Kohjima M, Izaki T, Ota K, Yoshinaga S, Inagaki F, Ito T, Sumimoto H: Molecular recognition in dimerization between PB1 domains. J Biol Chem 278: 43516-43524, 2003


  24. Mizukami Y, Sumimoto H, Takeshige K: Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells. Biochem Biophys Res Commun 314: 104-109, 2004


  25. Kawahara T, Kuwano Y, Teshima-Kondo S, Takeya R, Sumimoto H, Kishi K, Tsunawaki S, Hirayama T, Rokutan K: Role of NADPH oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells. J Immunol 172: 3051-3058, 2004


  26. Yuzawa S, Suzuki NN, Fujioka Y, Ogura K, Sumimoto H, Inagaki F: A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase. Genes Cells 9: 443-456, 2004


  27. Hashida S, Yuzawa S, Suzuki NN, Fujioka Y, Takikawa T, Sumimoto H, Inagaki F, Fujii H: Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production. J Biol Chem 279: 26378-26386, 2004


c@@ikwEw@wnȁj
  1. Takeda A, Perry G, Abraham NG, Dwyer BE, Kutty RK, Laitinen JT, Petersen RB, Smith MA: Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau. J Biol Chem 275: 5395-5399, 2000


  2. Gerst JL, Raina AK, Pirim I, Mcshea A, Harris PL, Siedlak SL, Takeda A, Petersen RB, Smith MA: Altered cell-matrix associated ADAM proteins in Alzheimer disease. J Neurosci Res 59: 680-684, 2000


  3. Tateyama M, Tobita M, Takeda A, Chida K, Onodera Y, Kikuchi A, Aoyagi N, Itoyama Y: DNA single-strand breaks are increased in muscle diseases with rimmed vacuoles. Acta Neuropathol 100: 390-394, 2000


  4. Kimpara T, Takeda A, Yamaguchi T, Arai H, Okita N, Takase S, Sasaki H, Itoyama Y: Increased bilirubin and its derivatives in cerebrospinal fluid in Alzheimerfs disease. Neurobiol Aging 21: 551-554, 2000


  5. Hasegawa T, Yamaguchi K, Wada T, Takeda A, Itoyama Y, Miyagi T: Molecular cloning of mouse ganglioside sialidase and its increased expression in neuro2a cell differentiation. J Biol Chem 275: 8007-8015, 2000


  6. Yamakawa K, Kuroda H, Fujihara K, Sato S, Nakashima I, Takeda A, Suzuki K, Itoyama Y: Familial neuromyelitis optica (Devicfs syndrome) with late onset in Japan. Neurology 55: 318-320, 2000


  7. Iwasaki K, Wang Q, Seki H, Satoh K, Takeda A, Arai H, Sasaki H: The effects of the traditional Chinese medicine, gBanxia Houpo Tang (Hange-Koboku To)h on the swallowing reflex in Parkinsonfs disease. Phytomedicine 7: 259-263, 2000


  8. Takeda A, Smith MA, Avila J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM: In Alzheimer disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. J Neurochem 75: 1234-1241, 2000


  9. Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA: Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci 18: 433-437, 2000


  10. Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: α2-Macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimerfs disease. NeuroReport 11: 1167-1171, 2000


  11. Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA: Activation of p38 kinase links tau phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59: 880-888, 2000


  12. Kanda A, Ebihara S, Arai H, Takeda A, Sasaki H: Parkinsonfs disease and impaired chemosensitivity to hypoxia. Lancet 356: 2100, 2000


  13. Raina AK, Zhu X, Monteiro M, Takeda A, Smith MA: Abortive oncogeny and cell cycle-mediated events in Alzheimer disease. Prog Cell Cycle Res 4: 235-242, 2000


  14. Raina AK, Zhu X, Rottkamp CA, Monteiro M, Takeda A, Smith MA: Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 61: 128-33, 2000


  15. Perry G, Nunomura A, Hirai K, Takeda A, Aliev G, Smith MA: Oxidative damage in Alzheimerfs disease: the metabolic dimension. Int J Dev Neurosci 18: 417-421, 2000


  16. Smith MA, Nunomura A, Zhu X, Takeda A, Perry G: Metabolic, metallic and mitotic sources of oxidative stress in Alzheimer disease.Antioxid Redox Signal 2: 413-420, 2000


  17. Kimura M, Matsushita S, Arai H, Takeda A, Higuchi S: No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinsonfs disease. Ann Neurol 49: 276-277, 2001


  18. Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Hu X-S, Takeda A, Itoh M, Sasaki H: [18F]FDG-PET study in dementia with Lewy bodies and Alzheimer disease. Prog Neuro-psychpharmacol Biol Psychiat 25: 447-456, 2001


  19. Takeda A, Fujihara K, Kikuchi A, Kimpara T, Itoyama Y: Dementia in Parkinsonfs disease: its incidence and a possible relationship with dopa-refractory symptoms. Psychogeriatrics 1: 119-122, 2001


  20. Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA: Oxidative damage is the earliest event in Alzheimer disease. J Neuropathol Exp Neurol 60: 759-767, 2001


  21. Kikuchi A, Takeda A, Kimpara T, Nakagawa M, Kawashima R, Sugiura M, Kinomura S, Fukuda H, Chida K, Itoyama Y: Hypoperfusion in the supplementary motor area, dorsolateral prefrontal cortex and insular cortex in Parkinson's disease. J Neurol Sci 193: 29-36, 2001


  22. Zhu X, Rottkamp CA, Takeda A, Boux H, Shimohama S, Perry G, Smith MA: Activation of MKK6, an upstream activator of p38, in Alzheimerfs disease. J Neurochem 79: 311-318, 2001


  23. Zhu X, Castellani RJ, Takeda A, Nunomura A, Atwood CS, Perry G, Smith MA: Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimerfs disease: gtwo hith hypothesis. Mech Ageing Dev 123: 39-46, 2001


c@r@iwEw@wnȁj
  1. Sato N, Imaizumi K, Manabe T, Taniguchi M, Hitomi J, Katayama T, Yoneda T, Morihara T, Yasuda Y, Takagi T, Kudo T, Tsuda T, Itoyama Y, Makifuchi T, Fraser EP, St. George-Hyslop P, Tohyama M: Increased production of β-amyloid and vulnerability to endoplasmic reticulum stress by an aberrant spliced form of presenilin 2. J Biol Chem 276: 2108-2114, 2001


  2. Katayama T, Imaizumi K, Honda A, Yoneda T, Kudo T, Takeda M, Mori K, Rozmahel R, Fraser P, St. George-Hyslop P, Tohyama M: Disturbed activation of endoplasmic reticulum stress transducers by familial Alzheimerfs disease-linked presenilin 1 mutations J Biol Chem 276: 43446-43454, 2001


  3. Manabe T, Katayama T, Sato N, Kudo T, Matsuzaki S, Imaizumi K, Tohyama M: The cytosolic inclusion bodies that consist of splice variants that lack exon 5 of the presenilin-2 gene differ obviously from Hirano bodies observed in the brain from sporadic cases of Alzheimerfs disease patients. Neurosci Lett 328: 198-200, 2002


  4. Yasuda Y, Kudo T, Katayama T, Imaizumi K, Yatera M, Okochi M, Yamamori H, Matsumoto N, Kida T, Fukumori A, Okumura M, Tohyama M, Takeda M: FAD-linked presenilin-1 mutants impede translation regulation under ER stress. Biochem Biophys Res Commun 296: 313-318, 2002


c@q@iŽRw@wEHwj
  1. Uchida A, Komiya Y, Tashiro T, Yorifuji H, Kishimoto T, Nabeshima Y, Hisanaga S: Neurofilaments of Klotho, the mutant mouse prematurely displaying symptoms resembling human aging. J Neurosci Res 64: 364-370, 2001


ʉ@W@i}gw, Տwnj
  1. Hoshi K, Yoshida K, Nakamura A, Tada T, Tamaoka A, Ikeda S: Cessation of cerebral hemorrhage recurrence associated with corticosteroid treatment in a patient with cerebral amyloid angiopathy. Amyloid 7: 284-288, 2000


  2. Cavani S, Tamaoka A, Moretti A, Marinelli L, Angelini G, Stefano SDi, Piombo G, Cazzulo V, Matsuno S, Shoji S, Furiya Y, Zaccheo D, Dagna-Bricarelli F, Tabaton M, Mori H: Plasma levels of amyloid beta 40 and 42 are independent from ApoE genotype and mental retardation in down syndrome. Am J Med Genet 95: 224-228, 2000


  3. Tamaoka A, Matsuno S, Ono S, Shimizu N, Shoji S: Increased amyloid β protein in the skin of patients with amyotrophic lateral sclerosis. J Neurol 247: 633-635, 2000


  4. Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, N Sahara, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimerfs disease. Neurology 54: 2319-2321, 2000


  5. Yausda M, Maeda S, Kawamata T, Tamaoka A, Yamamoto Y, Kuroda S, Maeda K, Tanaka C: Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy. J Neurol Neurosurg Psychiat 68: 220-223, 2000


  6. Mochizuki A, Tamaoka A, Shimohata A, Komatsuzaki Y, Shoji S: Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimerfs disease. Lancet 355: 42-43, 2000


  7. Harada H, Ohkoshi N, Fujita Y, Tamaoka A, Shoji S: Clinical improvement following interferon-alpha alone as an initial treatment in chronic inflammatory demyelinating polyneuropathy with chronic hepatitis C. Muscle Nerve 23: 295-296, 2000


  8. Ishii K, Tamaoka A, Shoji S: A case of primary focal lingual dystonia induced by speaking. Eur J Neurol 8: 507, 2001


  9. Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser EP, Shoji S, Nee EL, Pollen AD, St. George-Hyslop P, Ii K, Ohtake T, Kalaria NR, Rossor NM, Lantos LP, Cairns JN, LA Farrer, Mori H: Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging 22: 367-376, 2001


  10. Matsuno S, Tamaoka A, Yoshizawa K, Watanabe M, Shoji S: A case with mysthenia gravis (MG) emerging after splenectomy for idiopathic thrombocytopenic purpura (ITP): possible effects of thymectomy on autoantibodies. J Med 31: 327-332, 2001


  11. Tokuda T, Tamaoka A, Matsuno S, Sakurai S, Shimada H, Morita H, Ikeda S: Plasma levels of amyloid β proteins did not differ between subjects with and without taking statins. Ann Neurol 49: 546-547, 2001


  12. Watanabe M, Yamamoto N, Ohkoshi N, Nagata H, Kohno Y, Hayashi A, Tamaoka A, Shoji S: Corticosteroid- responsive asymmetric neuropathy with a myelin protein zero gene mutation. Neurology 59: 767-769, 2002


  13. Matsuno S, Watanabe M, Ohkoshi N, Anno I, Matsumaru Y, Tamaoka A, Shoji S: Enhanced magnetic resonance angiography of a spinal dural arteriovenous fistula. Arch Neurol 59: 1185, 2002


  14. Tokuda T, Oide T, Tamaoka A, Ishii K, Matsuno S, Ikeda S: Moderate or high doses of prednisolone (30-60 mg/day) for diseases other than AD decreases amyloid β peptides in CSF. Neurology 58: 1415-1418, 2002


  15. Fujita Y, Yoshizawa T, Sakata N, Okoshi N, Yamamoto N, Tamaoka A, Hommura S, Shoji S: Pictures in clinical medicine. Fungal endophthalmitis and Churg-Strauss syndrome. Intern Med 41: 167, 2002


  16. Miyawaki K, Nakamura H, Matsuno S, Tamaoka A, Doi K: Three-dimensional and fractal analyses of assemblies of amyloid β protein subtypes (Aβ40 and Aβ42(43)) in canine senile plaques. Acta Neuropathol 103: 228-236, 2002


  17. Ishii K, Klunk EW, Arawaka S, Debnath LM, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew JW, Mori H: Chrysamine and its derivative reduce amyloid beta-induced neurotoxicity in mice. Neurosci Lett 333: 5-8, 2002


  18. Ishii K, Tamaoka A, Matsuno S, Shoji S: Isolated peroneal nerve palsy complicating weight loss due to anterior pituitary hypofunction. Eur J Neurol 10: 187-188, 2003


  19. Ishii K, Tokuda T, Matsushima T, Miya F, Shoji S, Ikeda S, Tamaoka A: Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-beta (Abeta) 40 or Abeta 42 in humans. Neurosci Lett 350: 161-164, 2003         


  20. Ishii K, Tamaoka A, Otsuka F, Iwasaki N, Shin K, Matsui A, Endo G, Kumagai Y, Ishii T, Shoji S, Ogata T, Ishizaki M, Doi M, Shimojo N: Diphenylarsinic acid poisoning from chemical weapons in Kamisu, Japan. Ann Neurol 56: 741-745, 2004


  21. Ishii K, Tamaoka A, Shoji S: MRI of idiopathic lumbosacral plexopathy. Neurology 63: E6, 2004


  22. Ishii K, Tamaoka A, Fujita Y, Shoji S: Bladder and bowel dysfunction in chronic inflammatory demyelinating polyradiculoneuropathy. Eur J Intern Med 16: 211-213, 2005


  23. Kotliarova S, Jana RN, Sakamoto N, Kurosawa M, Miyazaki H, Nekooki MH, Doi Y, Machida, Wong KH, Suzuki T, Uchikawa C, Kotliarov Y, Uchida K, Nagao Y, Nagaoka U, Tamaoka A, Oyanagi K, Oyama F, Nukina N: Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine-EGFP fluorescent aggregates. J Neurochem 93: 641-653, 2005


  24. Ishizaki M, Yanaoka T, Nakamura M, Hakuta T, Ueno S, Komuro M, Shibata Kitamura M, Honda A, Doy M, Ishii K, Tamaoka A, Shimojo N, Ogata T, Nagasawa E, Hanaoka S: Detection of bis(diphenylarsine) oxide, diphenylarsinic acid and phenylarsonic acid, compounds probably derived from chemical warfare agents, in drinking well water. J Health Sci 51: 130-137. 2005


ʑ@[a@iswEwȁj
  1. Otaka A, Watanabe H, Mitsuyama E, Yukimasa A, Tamamura H, Fujii N: Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ, γ -difluoro-α,β-enoates. Tetrahedron Lett 42: 285-287, 2001


  2. Tamamura H, Sugioka M, Odagaki Y, Omagari A, Kan Y, Oishi S, Nakashima H, Yamamoto N, Stephen CP, Hamanaka N, Otaka A, Nobutaka F: Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity. Bioorg Med Chem Lett 11: 359-362, 2001


  3. Gotoh K, Yoshimori M, Kanbara K, Tamamura H, Kanamoto T, Mochizuki K, Fujii N, Nakashima H: Increase of R5 HIV-1 infection and CCR5 expression in T cells treated with high concentrations of CXCR4 antagonists and SDF-1. J Infect Chemother 7: 28-36, 2001


  4. Kanbara K, Sato S, Tanuma J, Tamamura H, Gotoh K, Yoshimori M, Kanamoto T, Kitano M, Fujii N, Nakashima H: Biological and genetic characterization of a human immunodeficiency virus strain resistant to CXCR4 antagonist T134. AIDS Res Hum Retroviruses 17: 615-622, 2001


  5. Tamamura H, Omagari A, Hiramatsu K, Gotoh K, Kanamoto T, Xu Y, Kodama E, Matsuoka M, Hattori T, Yamamoto N, Nakashima H, Otaka A, Fujii N: Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140. Bioorg Med Chem Lett 11: 1897-1902, 2001


  6. Tamamura H, Omagari A, Hiramatsu K, Kanamoto T, Gotoh K, Kanbara K, Yamamoto N, Nakashima H, Otaka A, Fujii N: Synthesis and evaluation of bifunctional anti-HIV agents based on specific CXCR4 antagonists-AZT conjugation. Bioorg Med Chem 9: 2179-2187, 2001


  7. Otaka A, Watanabe H, Yukimasa A, Oishi S, Tamamura H, Fujii N: New access to á-substituted (Z)-fluoroalkene dipeptide isosteres utilizing organocopper reagents under 'reduction-oxidative alkylation (R-OA)' conditions. Tetrahedron Lett 42: 5443-5446, 2001


  8. Oishi S, Tamamura H, Yamashita M, Odagaki Y, Hamanaka N, Otaka A, Fujii N: Stereoselective synthesis of a set of two functionalized (E)-alkene dipeptide isosteres of L-amino acid-L-Glu and L-amino acid-D-Glu. J Chem Soc Perkin Trans 1: 2445-2451, 2001


  9. Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N: Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multi-drug resistant HIV-1 strains. J Med Chem 46: 1764-1768, 2003


  10. Yasuda T, Poole AR, Shimizu M, Nakagawa T, Julovi MS, Tamamura H, Fujii N, Nakamura T: Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture. Arthritis Rheum 48: 1271-1280, 2003


  11. Otaka A, Yukimasa A, Watanabe J, Sasaki Y, Oishi S, Tamamura H, Fujii N: Application of samarium diiodide (SmI2)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives. Chem Commun 2003: 1834-1835, 2003


  12. Tamamura H, Kato T, Otaka A, Fujii N: Synthesis of potent beta-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies. Org Biomol Chem 1: 2468-2473, 2003


  13. Fujii N, Oishi S, Hiramatsu K, Araki T, Ueda S, Tamamura H, Otaka A, Kusano S, Terakubo S, Nakashima H, Broach AJ, Trent OJ, Wang Z, Peiper CS: Molecular-size reduction of a potent CXCR4-chemokine antagonist using orthogonal combination of conformation- and sequence-based libraries. Angew Chem Int Ed 42: 3251-3253, 2003


  14. Oonuma T, Morimatsu M, Nakagawa T, Uyama R, Sasaki N, Tamamura H, Fujii N, Hashimoto S, Yamamura H, Syuto B: Role of CXCR4 and SDF-1 in mammary tumor metastasis in the cat. J Vet Med Sci 65: 1069-1073, 2003


  15. Tamamura H, Hori A, Kanzaki N, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N: T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer. FEBS Lett 550: 79-83, 2003


  16. Tamamura H, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent OJ, Wang Z, Peiper CS, Nakashima H, Otaka A, Fujii N: Synthesis of potent CXCR4 inhibitors possessing low cytotoxicity and improved biostability based on T140 derivatives. Org Biomol Chem 1: 3656-3662, 2003


  17. Tamamura H, Hiramatsu K, Mizumoto M, Ueda S, Kusano S, Terakubo S, Akamatsu M, Yamamoto N, Trent OJ, Wang Z, Peiper CS, Nakashima H, Otaka A, Fujii N: Enhancement of the T140-based pharmacophores leads to the development of more potent and bio-stable CXCR4 antagonists. Org Biomol Chem1: 3663-3669, 2003


  18. Trent OJ, Wang Z, Murray LJ, Shao W, Tamamura H, Fujii N, Peiper CS: Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem 278: 47136-47144, 2003


  19. Mori T, Doi R, Koizumi M, Toyoda E, Ito D, Kami K, Masui T, Fujimoto K, Tamamura H, Hiramatsu K, Fujii N, Imamura M: CXCR4 antagonist inhibits stromal cell-derived factor 1-induced migration and invasion of human pancreatic cancer. Mol Cancer Ther 3: 29-37, 2004


  20. Tamamura H, Sigano MD, Lewin EN, Blumberg MP, Marquez EV: Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C (PK-C) through relocation of the carbonyl pharmacophore along the sn-1 side chain of DAG-lactones. J Med Chem 47: 644-655, 2004


  21. Peng H, Huang Y, Rose J, Erichsen D, Herek S, Fujii N, Tamamura H, Zheng J: Stromal cell-derived factor 1-mediated CXCR4 signaling in rat and human cortical neural progenitor cells. J Neurosci Res 76: 35-50, 2004


  22. Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent OJ, Wang Z, Peiper CS, Nakashima H, Otaka A, Fujii N: Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem2: 1255-1257, 2004


  23. Tamamura H, Fujii N: Two orthogonal approaches to overcome multi-drug resistant HIV-1s: development of protease inhibitors and entry inhibitors based on CXCR4 antagonists. Curr Drug Targets-Infect Disord 4: 103-110, 2004


  24. Otaka A, Watanabe J, Yukimasa A, Sasaki Y, Watanabe H, Kinoshita T, Oishi S, Tamamura H, Fujii N: SmI2-mediated reduction of γ,γ-difluoro α,β-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipeptide isosteres. J Org Chem 69: 1634-1645, 2004


  25. Yamamoto N, Yang R, Yoshinaka Y, Amari S, Nakano T, Cinatl J, Rabenau H, Doerr WH, Hunsmann G, Otaka A, Tamamura H, Fujii N, Yamamoto N: HIV Protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus. Biochem Biophys Res Commun 318: 719-725, 2004


  26. Takenaga M, Tamamura H, Hiramatsu K, Nakamura N, Yamaguchi Y, Kitagawa A, Kawai S, Nakashima H, Fujii N, Igarashi R: A single treatment with microcapsules containing a CXCR4 antagonist suppresses pulmonary metastasis of murine melanoma. Biochem Biophys Res Commun 320: 226-232, 2004


  27. Tamamura H, Fujisawa M, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N: Identification of a CXCR4 antagonist, a T140 analog, as an anti-rheumatoid arthritis agent. FEBS Lett 569: 99-104, 2004


  28. Otaka A, Ueda S, Tomita K, Yano Y, Tamamura H, Matsuzaki K, Fujii N: Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation. Chem Commun 15: 1722-1723, 2004


  29. Tamamura H, Sigano MD, Lewin EN, Peach LM, Nicklaus CM,Blumberg MP, Marquez EV: Conformationally constrained analogues of diacylglycerol (DAG). 23. Hydrophobic ligand-protein interactions versus ligand-lipid interactions of DAG-lactones with protein kinase C (PK-C). J Med Chem 47: 4858-4864, 2004


  30. Allen CDC, Ansel MK, Low C, Lesley R, Tamamura H, Fujii N, Cyster GJ: Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat Immunol 5: 943-952, 2004


  31. Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, Zamarchi R, Tamamura H, Fujii N, Semenzato G, Bianchi L-C, Amadori A: Chemokine receptor expression in EBV-associated lymphoproliferation in Hu/SCID mice: Implications for CXCL12/CXCR4 axis in lymphoma generation. Blood 105: 931-939, 2005


  32. Tamamura H, Hiramatsu K, Ueda S, Wang Z, Kusano S, Terakubo S, Trent OJ, Peiper CS, Yamamoto N, Nakashima H, Otaka A, Fujii N: Stereoselective synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of pseudopeptide analogs of the CXCR4 antagonist FC131. J Med Chem 48: 380-391, 2005


  33. Nameki D, Kodama E, Ikeuchi M, Mabuchi N, Otaka A, Tamamura H, Ohno M, Fujii N, Matsuoka M: Mutations conferring resistance to HIV-1 fusion inhibitors are restricted by gp41 and rev responsive element functions. J Virol 79: 764-770, 2005


  34. Zannettino AC, Farrugia AN, Kortesidis A, Manavis J, To LB, Martin SK, Diamond P, Tamamura H, Lapidot T, Fujii N, Gronthos S: Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 65: 1700-1709, 2005


  35. Tamamura H, Otaka A, Fujii N: Development of anti-HIV agents targeting dynamic supramolecular mechanism: Entry and fusion inhibitors based on CXCR4/CCR5 antagonists and gp41-C34-remodeling peptides. Curr HIV Res 3:289-301,2005


  36. Percherancier Y, Berchiche Y, Slight I, Volkmer-Engert R, Tamamura H, Fujii N, Bouvier M, Heveker N: Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers. J Biol Chem 280: 9895-9903, 2005


  37. Tamamura H, Araki T, Ueda S, Wang Z, Oishi S, Esaka A, Trent OJ, Nakashima H, Yamamoto N, Peiper CS, Otaka A, Fujii N: Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds. J Med Chem 48: 3280-3289, 2005


  38. Burger M, Hartmann T, Rawluk J, Tamamura H, Fujii N, Kipps JT, Burger AJ: Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106: 1824-1830, 2005


  39. Niida A, Oishi S, Sasaki Y, Mizumoto M, Tamamura H, Fujii N, Otaka A: Facile access to (Z)-alkene-containing diketopiperazine mimetics utilizing organocopper-mediated anti-SN2' reactions. Tetrahedron Lett 46: 4183-4186, 2005


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  1. Oshitari T, Dezawa M, Okada S, Takano M, Negishi H, Horie H, Sawada H, Tokuhisa T, Adachi-Usami E: The role of c-fos in cell death and regeneration of retinal ganglion cells. Invest Ophthalmol Vis Sci 43: 2442-2449, 2002


  2. Mo X, Yokoyama A, Oshitari T, Negishi H, Dezawa M, Mizota A, Adachi-Usami E: Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats. Invest Ophthalmol Vis Sci 43: 2401-2405, 2002


  3. Dezawa M, Takano M, Negishi H, Mo X, Oshitari T, Sawada H: Gene transfer into retinal ganglion cells by in vivo electroporation: A new approach. Micron 33: 1-6, 2002


  4. Yamazaki H, Ohguro H. Maeda T, Maruyama I, Takano Y, Metoki T, Nakazawa M, Sawada H, Dezawa M: Nilvadipine, a Ca2+ antagonist, effectively preserves retinal morphology and functions in Royal College Surgeons rat. Invest Ophthalmol Vis Sci 43: 919-926, 2002


  5. Takano M, Horie H, Iijima Y, Dezawa M, Sawada H, Ishikawa Y: Brain-derived neurotrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitro. Exp Eye Res 74: 319-323, 2002


  6. Yamada H, Dezawa M, Shimazu S, Baba M, Sawada H, Kuroiwa Y, Yamamoto I, Kanno H: Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease. Ann Neurol 54: 352-359, 2003


  7. Ohmura M, Ogawa T, Ono M, Dezawa M, Hosaka M, Kubota Y, Sawada H: Increment of murine spermatogonial cell number by gonadotropin-releasing hormone analogue is independent of stem cell factor c-kit signal. Biol Reprod 68: 2304-2313, 2003


  8. Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C: Specific induction of neuronal cells from bone-marrow stromal cells and application for autologous transplantation. J Clin Invest 113: 1701-1710, 2004


  9. Ohta M, Suzuki Y, Chou H, Ishikawa N, Suzuki S, Tanihara M, Suzuki Y, Mizushima Y, Dezawa M, Ide C: Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. J Biomed Mater Res 71A: 661-668, 2004


  10. Miyawaki T, Uemura A, Dezawa M, Yu S, Ide C, Nishikawa S, Honda Y, Tanabe Y, Tanabe T: Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina. J Neurosci 24: 8124-8134, 2004


  11. Mimura T, Dezawa M, Kanno H, Sawada H, Yamamoto I: Peripheral nerve regeneration by transplantation of bone marrow stromal cell-derived Schwann cells in adult rats. J Neurosurg 101: 806-812, 2004


  12. Ohta M, Suzuki Y, Noda T, Kataoka K, Chou H, Ishikawa N, Kitada M, Matsumoto N, Dezawa M, Suzuki S, Ide C: Implantation of neural stem cells via cerebrospinal fluid into the injured root. NeuroReport 15: 1249-1253, 2004


  13. Ohta M, Suzuki Y, Noda T, Ejiri Y, Dezawa M, Kataoka K, Chou H, Matsumoto N, Iwashita Y, Mizuta E, Kuno S, Ide C: Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Exp Neurol 187: 266-278, 2004


  14. Takano Y, Ohguro H, Dezawa M, Ishikawa H, Yamazaki H, Ohguro I, Mamiya K, Metoki T, Ishikawa F, Nakazawa M: Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun 313: 1015-1022, 2004


  15. Dezawa M, Ishikawa H, Hoshino M, Itokazu Y, Yoshihara T, Takeda S, Ide C, Nabeshima Y: Efficient induction of skeletal muscle lineage cells from bone marrow stromal cells and application for muscle degenerative disorders. Science 309: 314-317, 2005


  16. Itokazu Y, Kitada M, Mizoguchi A, Matsumoto N, Dezawa M, Shimizu A, Ide C: Choroid plexus ependymal cells host neural progenitor cells in the rat. Glia 53:32-42,2005


  17. Tanaka Y, Kanno H, Dezawa M, Mimura T, Kubo A, Yamamoto I: Differentiation of neural progenitor cells and the role of von Hippel-Lindau protein under normoxic and anoxic conditions. Neurosci Lett 383: 28-32, 2005


  18. Watanabe Y, Matsumoto N, Dezawa M, Itokazu Y, Yoshihara T, Ide C: Conditioned medium of the primary culture of rat choroid plexus epithelial (modified ependymal) cells enhances neurite outgrowth and survival of hippocampal neurons. Neurosci Lett 379: 158-163, 2005


  19. Xu Y, Tamamaki N, Noda T, Kimura K, Itokazu Y, Matsumoto N, Dezawa M, Ide C: Neurogenesis in the ependymal layer of the adult rat 3rd ventricle. Exp Neurol192: 251-264, 2005


  20. Kamata T, Koda M, Dezawa M, Yoshinaga K, Hashimoto M, Koshizuka S, Nishio Y, Moriya H, Yamazaki M: Transplantation of bone marrow stromal cell-derived Schwann cells promotes axonal regeneration and functional recovery after complete transection of adult rat spinal cord. J Neuropathol Exp Neurol 64: 37-45, 2005


  21. Ishikawa H, Takano M, Matsumoto N, Sawada H, Ide C, Mimura O, Dezawa M: The effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with contact type electrode. Gene Ther 12: 289-298, 2005


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  1. Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H: Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22: 1511-1516, 2003


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  6. Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: Highly efficient incorporation of biotin-tag and cross-linking groups. Chem Commun 17: 2244-2245, 2003


  7. Schroeter E-H, Ilagan MXG, Brunkan AL, Hecimovic S, Li Y-L, Xu M, Lewis HD, Saxena MT, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Shearman M, Goate A, Wolfe MS, Kopan R: A presenilin dimer at the core of the γ-secretase enzyme: Insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci USA 100: 13075-13080, 2003


  8. Matsubayashi H, Sese S, Lee J-S, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S: Biochemical characterization of Drosophila Wingless signaling pathway based on RNA interference. Mol Cell Biol24: 2012-2024, 2004


  9. Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T, Natsugari H: Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azido pentafluorophenyl ester: synthesis and biological evaluation of LY411575 analogues. Tetrahedron Lett45: 2323-2326, 2004


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  11. Kawasumi M, Chiba T, Yamada M, Miyamae-Kaneko M, Matsuoka M, Nakahara J, Tomita T, Iwatsubo T, Kato S, Aiso S, Nishimoto I, Kouyama K: Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimerfs disease in aged mice. Eur J Neurosci 19: 2826-2838, 2004


  12. Hayashi I, Urano Y, Fukuda R, Isoo N, Kodama T, Hamakubo T, Tomita T, Iwatsubo T: Selective reconstitution and recovery of functional γ-secretase complex on budded baculovirus particles. J Biol Chem 279: 38040-38046, 2004


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  1. Yamaguchi I, Hasegawa K, Naiki H, Mitsu T, Matuo Y, Gejyo F: Extension of Aβ2M amyloid fibrils with recombinant human β2-microglobulin. Amyloid 8: 30-40, 2001


  2. Yamaguchi I, Hasegawa K, Takahashi N, Gejyo F, Naiki H: Apolipoprotein E inhibits the depolymerization of β2-microglobulin-related amyloid fibrils at a neutral pH. Biochemistry 40: 8499-8507, 2001


  3. Ohhashi Y, Hagihara Y, Kozhukh GV, Hoshino M, Hasegawa K, Yamaguchi I, Naiki H, Goto Y: The intrachain disulfide bond of β2-microglobulin is inessential for the immunoglobulin fold at neutral pH but essential for amyloid fibril formation at acidic pH. J Biochem 131: 45-52, 2002


  4. Kozhukh GV,Hagihara Y, Kawakami T, Hasegawa K, Naiki H, Goto Y: Investigation of a peptide responsible for amyloid fibril formation of β2-microglobulin by Acromobacter protease I. J Biol Chem 277: 1310-1315, 2002


  5. Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H: Nordihydroguaiaretic acid potently breaks down preformed Alzheimerfs β-amyloid fibrils in vitro. J Neurochem 81: 434-440, 2002


  6. Martsev SP, Dubnovitsky AP, Vlasov AP, Hoshino M, Hasegawa K, Naiki H, Goto Y: Amyloid fibril formation of mouse VL domain under acidic pH. Biochemistry 41: 3389-3395, 2002


  7. Hoshino M, Katou H, Hagihara Y, Hasegawa K, Naiki H, Goto Y: Mapping the core of the β2-microglobulin amyloid fibril by H/D exchange. Nat Struct Biol 9: 332-336, 2002


  8. Hong D, Gozu M, Hasegawa K, Naiki H, Goto Y: Conformation of β2-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond. J Biol Chem 277: 21554-21560, 2002


  9. Ono K, Hasegawa K, Yamada M, Naiki H: Nicotine breaks down preformed Alzheimerfs β-amyloid fibrils in vitro. Biol Psychiat 52: 880-886, 2002


  10. Katou H, Kanno T, Hoshino M, Hagihara Y, Tanaka H, Kawai T, Hasegawa K, Naiki H, Goto Y: The role of disulfide bond in the amyloidogenic state of β2-microglobulin studied by heteronuclear NMR. Protein Sci 11: 2218-2229, 2002


  11. Takahashi N, Hasegawa K, Yamaguchi I, Okada H, Ueda T, Gejyo F, Naiki H: Establishment of a first-order kinetic model of light chain-associated amyloid fibril extension in vitro. Biochim Biophys Acta 1601: 110-120, 2002


  12. Hasegawa K, Ono K, Yamada M, Naiki H: Kinetic modeling and determination of reaction constants of Alzheimer's β-amyloid fibril extension and dissociation using surface plasmon resonance. Biochemistry 41: 13489-13498, 2002


  13. Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F, Kitamoto T: Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimerfs disease. J Neurochem 82: 1137-1147, 2002


  14. Ban T, Hamada D, Hasegawa K, Naiki H, Goto Y: Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence. J Biol Chem 278: 16462-16465, 2003


  15. Hasegawa K, Ohhashi Y, Yamaguchi I, Takahashi N, Tsutsumi S, Goto Y, Gejyo F, Naiki H: Amyloidogenic synthetic peptides of β2-microglobulin: a role of the disulfide bond. Biochem Biophys Res Commun 304: 101-106, 2003


  16. Yamaguchi I, Suda H, Tsuzuike N, Seto K, Seki M, Yamaguchi Y, Hasegawa K, Takahashi N, Yamamoto S, Gejyo F, Naiki H: Glycosaminoglycan and proteoglycan inhibit the depolymerization of β2-microglobulin amyloid fibrils in vitro. Kidney Int 64: 1080-1088, 2003


  17. Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M: Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimerfs disease. J Neurochem 87: 172-181, 2003


  18. Gozu M, Lee YH, Ohhashi Y, Hoshino M, Naiki H, Goto Y: Conformational dynamics of β2-microglobulin analyzed by reduction and reoxidation of the disulfide bond. J Biochem 133: 731-736, 2003


  19. Chiba T, Hagihara Y, Higurashi T, Hasegawa K, Naiki H, Goto Y: Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of β2-microglobulin. J Biol Chem 278: 47016-47024, 2003


  20. Hirota-Nakaoka N, Hasegawa K, Naiki H, Goto Y: Dissolution of β2-microglobulin amyloid fibrils by dimethylsulfoxide. J Biochem 134: 159-164, 2003


  21. Yamamoto S, Yamaguchi I, Hasegawa K, Tsutsumi S, Goto Y, Gejyo F, Naiki H: Glycosaminoglycans enhance the trifluoroethanol-induced extension of β2-microglobulin-related amyloid fibrils at a neutral pH. J Am Soc Nephrol 15: 126-133, 2004


  22. Ohhashi Y, Hasegawa K, Naiki H, Goto Y: Optimum amyloid fibril formation of a peptide fragment suggests the amyloidogenic preference of beta 2-microglobulin under physiological conditions. J Biol Chem 279: 10814-10821, 2004


  23. Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein. J Neurochem 90: 62-69, 2004


  24. Mori I, Yokochi T, Koide N, Sugiyama T, Yoshida T, Kimura Y, Naiki H, Matsubara R, Takeuchi T, Nishiyama Y: PCR search for the herpes simplex virus type 1 genome in brain sections of patients with familial Alzheimerfs disease. J Clin Microbiol 42: 936-937, 2004


  25. Villanueva J, Hoshino M, Katou H, Kardos J, Hasegawa K, Naiki H, Goto Y: Increase in the conformational flexibility of β2-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis. Protein Sci 13: 797-809, 2004


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  29. Fu X, Korenaga T, Fu L, Xing Y, Guo Z, Matsushita T, Hosokawa M, Naiki H, Baba S, Kawata Y, Ikeda S, Ishihara T, Mori M, Higuchi K: Induction of AApoAII amyloidosis by various heterogeneous amyloid fibrils. FEBS Lett 563: 179-184, 2004


  30. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K: A seed for Alzheimer amyloid in the brain. J Neurosci 24: 4894-4902, 2004


  31. Korenaga T, Fu X, Xing Y, Matsusita T, Kuramoto K, Syumiya S, Hasegawa K, Naiki H, Ueno M, Ishihara T, Hosokawa M, Mori M, Higuchi K: Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils. Am J Pathol 164: 1597-1606, 2004


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  33. Mori I, Kimura Y, Naiki H, Matsubara R, Takeuchi T, Yokochi T, Nishiyama Y: Reactivation of HSV-1 in the brain of patients with familial Alzheimerfs disease. J Med Virol 73: 605-611, 2004


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  35. Ono K, Hasegawa K, Naiki H, Yamada M: Anti-amyloidogenic activity of tannic acid and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro. Biochim Biophys Acta 1690: 193-202, 2004


  36. Konno T, Oiki S, Hasegawa K, Naiki H: Anionic contribution for fibrous maturation of proto-fibrillar assemblies of human tau repeat domain in a fluoro-alcohol solution. Biochemistry 43: 13613-13620, 2004


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  38. Narimoto T, Sakurai K, Okamoto A, Chatani E, Hoshino M, Hasegawa K, Naiki H, Goto Y: Conformational stability of amyloid fibrils of β2-microglobulin probed by guanidine-hydrochloride-induced unfolding. FEBS Lett 576: 313-319, 2004


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  41. Kihara M, Chatani E, Sakai M, Hasegawa K, Naiki H, Goto Y: Seeding-dependent maturation of β2-microglobulin amyloid fibrils at neutral pH. J Biol Chem 280: 12012-12018, 2005


  42. Raman B, Chatani E, Kihara M, Ban T, Sakai M, Hasegawa K, Naiki H, Rao CM, Goto Y: Critical balance of electrostatic and hydrophobic interactions is required for β2-microglobulin amyloid fibril growth and stability. Biochemistry 44: 1288-1299, 2005


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  45. Ono K, Hasegawa K, Naiki H, Yamada M: Preformed beta-amyloid fibrils are destabilized by coenzyme Q10 in vitro. Biochem Biophys Res Commun 330: 111-116, 2005


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  1. Iida R, Saito K, Yamada K, Basile A, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M, Nabeshima T: Suppression of neurocognitive damage in LP-BM5-infected mice with a targeted deletion of the TNF-α gene. FASEB J 14: 1023-1031, 2000


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  3. Tang YP, Yamada K, Kanou Y, Miyazaki T, Xiong XL, Kambe F, Murata Y, Seo H, Nabeshima T: Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of β-amyloid in rats. Mol Brain Res 80: 188-197, 2000


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  5. Fukuta T, Nitta A, Itoh A, Furukawa S, Nabeshima T: Difference in toxicity of β-amyloid peptide with aging in relation to nerve growth factor content in rat brain. J Neural Transm 108: 221-230, 2001


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{@NO@iwj
  1. Takahashi H, Hirai Y, Migita M, Seino Y, Fukuda Y, Sakuraba H, Kase R, Kobayashi T, Hashimoto Y, Shimada T: Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene trasfer. Proc Natl Acad Sci USA 99: 13777-13782, 2002


  2. Yamaji T, Teranishi T, Alphey SM, Crocker RP, Hashimoto Y: A small region of the natural killer cell receptor, Siglec-7, is responsible for the unique specificity for α2,8 disialyl and branched α2,6sialyl residues: a comparison with Siglec-9. J Biol Chem 277: 6324-6332, 2002


  3. Nakamura K, Yamaji T, Crocker RP, Suzuki A, Hashimoto Y: Lymph node microphages, but not spleen macrophages, express high levels of unmasked sialoadhesin: Implication for the adhesive properties of macrophages in vivo. Glycobiology12: 1-8, 2002


  4. Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido CT, Hashimoto Y:  Characterization of alpha2, 6sialyltransferase cleavage by Alzheimerfs beta-secretase (BACE1). J Biol Chem 278: 14865-14871, 2003


  5. Chen N, Furuya A, Shinoda Y, Yumoto M, Ohtake A, Sato K, Doi H, Hashimoto Y, Kudo Y, Higashi H: Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization.  Neuroscience 122: 985-995, 2003


  6. Chen N, Furuya S, Doi H, Hashimoto Y, Kudo Y, Higashi H: Ganglioside/Calmodurin kinase II signal inducing cdc42-mediated neuronal actin-reorganization. Neuroscience 120: 163-176, 2003


  7. Kitazume S, Suzuki M, Saido CT, Hashimoto Y: Involvement of proteases in glycosyltransferase secretion: Alzheimerfs beta-secretase-dependent cleavage and a following processing by an aminopeptidase. Glycoconj J 21: 25-29, 2004


  8. Miyazaki K, Ohmori K, Izawa M, Koike T, Furukawa K, Yamaji T, Hashimoto Y, Suzuki A, Kannagi R: Loss of disialyl Lewisa, the ligand for lymphocyte inhibitory receptor Siglec-7, associated with increased sialyl Lewisa expression on human colon cancers. Cancer Res 64: 4498-4505, 2004


  9. Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido CT, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531,2004


  10. Ichinose I, Hashimoto Y, Kunitake T: Overall wrapping of bio-macromolecules (dextran, amylopectin, and horse heart cytochrome c) with ultrathin silicate layer. Chem Lett 33: 656-657, 2004


  11. Kitazume S, Saido CT, Hashimoto Y: Alzheimerfs beta-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconj J 20: 59-62, 2004


  12. Kitazume S, Oka R, Tachida Y, Ogawa K, Nakagawa K, Luo Y, Citron M, Shitara H, Taya C, Yonekawa H, Paulson CJ, Miyoshi E, Taniguchi N, Hashimoto Y: In vivo cleavage of alpha2, 6-sialyltransferase by Alzheimerfs beta-secretase (BACE1). J Biol Chem 280: 8589-8595, 2005


  13. Yamaji T, Mitsuki M, Teranishi T, Hashimoto Y: Characterization of inhibitory signaling motifs of the natural killer cell receptor Siglec-7: Attenuated recruitment of phosphatases by the receptor is attributed to two amino acids in the motifs. Glycobiology 15: 1-10, 2005


  14. Kotani N, Kitazume S,Kamimura K,Takeo S, Aigaki T, Nakato H,Hashimoto Y: Characterization of Drosophila aspartic proteases that induce the secretion of a Golgi-resident transferase, heparan sulfate 6-O-sulfotransferase. J Biochem 137: 315-322, 2005


J@l@is_wj
  1. Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H: Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropahol 101: 285-293, 2001


  2. Mori H, Motoi Y, Kobayashi T, Hasegawa M, Yamamura A, Iwatsubo T, Mizuno Y: Tau accumulation in a patient with pallidonigroluysian atrophy. Neurosci Lett 309: 89-92, 2001


  3. Miyamoto K, Kowalska A, Hasegawa M, Tabira T, Takahashi K, Araki W, Akiguchi I, Ikemoto A: Familial frontotemporal dementia and parkinsonism with a novel mutation at an intron 10+11-splice site in the tau gene. Ann Neurol 50: 117-120, 2001


  4. Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan. Ann Neurol 49: 501-511, 2001


  5. Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation of p35 to p25 in postmortem human and rat brain. FEBS Lett 489: 46-50, 2001


  6. Fujiwara H, Hasegawa M, Domae N, Kawashima A, Masliah E, Goldberg S, Shen J, Takio K, Iwatsubo T: Alpha-synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4: 160-164, 2002


  7. Kowalska A, Hasegawa M, Miyamoto K, Akiguchi I, Ikemoto A, Takahashi K, Araki W, Tabira T: A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17. J Appl Genet 43, 535-543, 2002


  8. Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann D, Iwatsubo T: Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002


  9. Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest 110: 1429-1439, 2002


  10. Ohara H, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathological study of an unusual case of sporadic tauopathy: a variant of corticobasal degeneration? Neurosci Lett 330: 84-88, 2002


  11. Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C: Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 3: 583-588, 2002


  12. Miake T, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of alpha-synuclein filaments. J Biol Chem 277: 19213-19219, 2002


  13. Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51: 525-530, 2002


  14. Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesion is recapitulated in alpha-synuclein transgenic Drosophila. Neurosci Lett 336: 155-158, 2003


  15. Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology. Ann Neurol 53: 133-137, 2003


  16. Mori F, Piao YS, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: Alpha-synuclein accumulations in Purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003


  17. Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated alpha-synuclein in aging human brain. J Neuropathol Exp Neurol 62: 644-654. 2003


  18. Arai T, Nonaka T, Hasegawa M, Akiyama H, Yoshida M, Hashizume Y, Tsuchiya K, Oda T, Ikeda K: Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. Neurosci Lett 342: 41-44, 2003


  19. Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, Tsuchiya K, Iseki E, Yagishita S, Oda T, Mochizuki A: Identification of amino-terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration. Ann Neurol 55: 72-79, 2004


  20. Taniguchi S, McDonagh AM, Pickering-Brown SM, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathol Appl Neurobiol 30: 1-18, 2004


  21. Hirai Y, Fujita SC, Iwatsubo T, Hasegawa M: Phosphorylated alpha-synuclein in normal mouse brain. FEBS Lett 572: 227-232, 2004


  22. Umeda Y, Taniguchi S, Arima K, Piao YS, Takahashi H, Iwatsubo T, Mann D, Hasegawa M: Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neurosci Lett 359: 151-154, 2004


  23. Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 107: 292-298, 2004


  24. Pickering-Brown SM, Baker M, Nonaka T, Ikeda K, Sharma S, Mackenzie J, Simpson SA, Moore JW, Snowden JS, de Silva R, Revesz T, Hasegawa M, Hutton M, Mann DM: Frontotemporal dementia with Pick-type histology associated with Q336R mutation in the tau gene. Brain 127: 1415-1426, 2004


  25. Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhlendahl S, Leal-Ortiz S, Goedert M, Garner C, Cuenda A: Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD-95 by activation of SAPK3/p38gamma and ERK1/ERK2. Biochem J 380: 19-30, 2004


  26. Hasegawa M: Beta-Amyloid and tau protein. Psychogeriatrics 4 [Suppl 2]: S62-69, 2004


  27. Nonaka T, Iwatsubo T, Hasegawa M: Ubiquitination of alpha-synuclein. Biochemistry 44: 361-368, 2005


  28. Taniguchi S, Suzuki N, Masuda, M, Hisanaga S, Iwatsubo T, Goedert M, Hasegawa M: Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols and porphyrins. J Biol Chem 280: 7614-7623, 2005


  29. Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Chishti MA, Harigaya Y, Abe K, Okamoto K, St George-Hyslop P, Westaway D: Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol 166: 521-531, 2005


@_@iBwEw@w@j
  1. Hayakawa H, Kuwano M, Sekiguchi M: Specific binding of 8-oxoguanine-containing RNA to polynucleotide phosphorylase protein.Biochemistry 40: 9977-9982, 2001


c@G@iQnwE̒ߌj
  1. Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N: MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol 158: 541-549, 2002


  2. Sato T, Sato-Harada R, Takano M, Kato S, Saburi S, Harada A: Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons. Neurosci Lett 325: 83-86, 2002


  3. Hayashi K, Kawai-Hirai R, Harada A, Takata K: Inhibitory neurons from fetal rat cerebral cortex exert delayed axon formation and active migration in vitro. J Cell Sci 116: 4419-4428, 2003


  4. Oyama F, Kotliarova S, Harada A, Ito M, Miyazaki H, Ueyama Y, Hirokawa N, Nukina N, Ihara Y: Gem GTPase and tau: morphological changes induced by gem GTPase in CHO cells are antagonized by tau. J Biol Chem 279: 27272-27277, 2004


jJ@Nv@iQnwEwE_oȁj
  1. Tomidokoro Y, HarigayaY, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M: Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol 194: 500-506, 2001


  2. Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S: The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently. Neurobiol Aging 22: 209-215, 2001


  3. Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park J, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M: Aβ amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice. Neurosci Lett 299: 169-172, 2001


  4. Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K: Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiat 70: 386-9, 2001


  5. Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castaño EM, St. George-Hyslop P, Shoji M: Generation of amyloid β protein from a presenilin-1 and βAPP complex. Biochem Biophys Res Commun 292: 571-578, 2002


  6. Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia and the lack of PHF-typed, dystrophic neuritis. Virchows Arch 441: 358-367, 2002


@ML@iQwEȊwxZ^[j
  1. Kamataki A, Takahashi S, Masamura K, Iwasaki T, Hattori H, Naiki H, Yamada K, Suzuki J, Miyamori I, Sakai J, Fujino T, Yamamoto TT: Remnant lipoprotein particles are taken up into myocardium through VLDL receptor - a possible mechanism for cardiac fatty acid metabolism.Biochem Biophys Res Commun 293: 1007-1013, 2000


  2. Minekura H, Kang M-J, Inagaki Y, Suzuki H, Sato H, Fujino T, Yamamoto TT: Genomic organization and transcription unit of the human acyl-CoA synthetase 3 gene. Gene 278: 185-195, 2001


  3. Fujino T, Takei YA, Sone H, Ioka RX, Kamataki A, Magoori K, Takahashi S, Sakai J, Yamamoto TTFMolecular identification and characterization of two medium-chain acyl-CoA synthetases, MACS1 and the Sa gene product. J Biol Chem 276: 35961-35966, 2001


  4. Ikeda Y, Yamamoto JcOkamura M, Fujino T, Takahashi S, Takeuchi K, Osborne TF, Yamamoto TT, Ito S, Sakai J: Transcriptional regulation of the murine acetyl CoA synthetase 1 gene through multiple clustered binding site for SREBPs and a single neighboring site for Sp1. J Biol Chem 276: 34259-34269, 2001


  5. Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT: Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate.J Biol Chem 276: 11420-11426, 2001


  6. Takahashi S, Sakai J, Fujino T, Miyamori I, Yamamoto TT: The very low density lipoprotein (VLDL) receptor - a peripheral lipoprotein receptor for remnant lipoproteins into fatty acid active tissues. Mol Cell Biochem 248: 121-127, 2003


  7. Magoori K, Kang M-J, Iwazaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim D-H, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui U, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT: Severe hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E. J Biol Chem 278: 11331-11338, 2003


  8. Ioka RX, Kang M-J, Kamiyama S, Kim D-H, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT: Expression cloning and characterization of a novel GPI-anchored HDL binding protein, GPI-HBP1. J Biol Chem 278: 7344-7349, 2003


  9. Fujino T, Asaba H, Kang M-J, Ikeda Y, Sone H, Takada S, Kim D-H, Ioka R X, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT: LDL receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 100: 229-234, 2003


  10. Iwasaki T, Takahashi S, Ishihara M, Takahashi M, Ikeda U, Shimada K, Fujino T, Yamamoto TT, Hattori H, Emi M: The important role for beta-VLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor. J Hum Genet 49: 622-628, 2004


  11. Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Ioka RX, Iwasaki S, Kaneko I, Takahashi S, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J: A krüppel-like factor KLF 15 mediates fasting-Induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene, AceCS2. J Biol Chem 279: 16954-16962, 2004


  12. Takahashi S, Sakai J, Fujino T, Hattori H, Zenimaru Y, Suzuki J, Miyamori I, Yamamoto TT: The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor. J Atheroscler Thromb 11: 200-208, 2004


  13. IwasakiT, Takahashi S, Takahashi M, Zenimaru Y, Kujiraoka T, Ishihara M, Nagano M, Suzuki J, Miyamori I, Naiki H, Sakai J, Fujino T, Norman E Miller NE, Yamamoto TT, Hattori H: Deficiency of the very low-density lipoprotein (vldl) receptors in streptozotocin-induced diabetic rats: insulin-dependency of the vldl receptor. Endocrinology146: 3286-3294, 2005


Ð@q@ikwEwj
  1. Furukawa K, DfSouza I, Crudder CH, Onodera H, Itoyama Y, Poorkaj P, Bird TD, Schellenberg GD: Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism. NeuroReport 11: 57-60, 2000


@@iswEw@wȁj
  1. Kakio A, Nishimoto S, Yanagisawa K, Kozutsumi Y, Matsuzaki K: Interactions of amyloid β-protein with various gangliosides in raft-like membranes: importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 41: 7385-7390, 2002


  2. Yanagisawa K, Matsuzaki K: Cholesterol-dependent aggregation of β-protein. Ann NY Acad Sci 977: 384-386, 2002


  3. Tachi T, Epand RF, Epand RM, Matsuzaki K: Position-dependent hydrophobicity of the antimicrobial magainin peptide affects the mode of peptide-lipid interactions and selective toxicity. Biochemistry 41: 10723-10731, 2002


  4. Yano Y, Matsuzaki K: Membrane insertion and dissociation processes of a model transmembrane helix. Biochemistry 41: 12407-12413, 2002


  5. Kakio A, Nishimoto A, Kozutsumi Y, Matsuzaki K: Formation of a membrane-active from of amyloid beta-protein in raft-like model membranes. Biochem Biophys Res Commun 303:514-518, 2003


  6. Zou K, Kim D, Kakio A, Byun K, Gong JS, Kim J, Kim M, Sawamura N, Nishimoto S, Matsuzaki K, Lee B, Yanagisawa K, Michikawa M: Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ 1-42 in culture and in rat brain. J Neurochem. 87: 609-619, 2003


  7. Takeshima K, Chikushi A, Lee KK, Yonehara S, Matsuzaki K: Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes. J Biol Chem 278: 1310-1315, 2003


  8. Makino A, Baba T, Fujimoto K, Iwamoto K, Yano Y, Matsuzaki K, Kobayashi T: Cinnamycin (Ro 09-0198) promotes cell binding and toxicity by inducing transbilayer lipid movement. J Biol Chem 278: 3204-3209, 2003


  9. Kakio A, Yano Y, Takai D, Kuroda Y, Matsumoto O, Kozutsumi Y, Matsuzaki K: Interaction between amyloid β-protein aggregates and membranes. J Pept Sci 10: 612-621, 2004


  10. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K: A seed for Alzheimer amyloid in the brain. J Neurosci 24: 4894-4902, 2004


  11. Wakabayashi M, Okada T, Kozutsumi Y, Matsuzaki K: GM1 ganglioside-mediated accumulation of amyloid β-protein on cell membranes. Biochem Biophys Res Commun 328: 1019-1023, 2005


  12. Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid β-protein. J Neurochem 90: 62-69, 2005


@xN@iÃZ^[Ej
  1. Matsubara E, Shoji M, Murakami T, Abe K, Frangione B, Ghiso J: Platelet microparticles as carriers of soluble Alzheimerfs amyloid beta (sAβ). Ann NY Acad Sci 977: 340-348, 2002


  2. Matsubara E, Shoji M, Abe K, Frangione B, Ghiso J: Vascular amyloidosis in neurodegerative conditions. Drug News Perspectives 15: 439-444, 2002


  3. Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002


  4. Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castano EM, St George-Hyslop P, Shoji M: Generation of amyloid beta protein from a presenilin-1 and betaAPP complex. Biochem Biophys Res Commun 292: 571-578, 2002


  5. Shoji M, Fukushima K, Wakayama M, Shizuka-Ikeda M, Ikeda Y, Kawakami A, Sakazume Y, Ikeda M, Harigaya Y, Matsubara E, Kawarabayashi T, Murakami T, Nagano I, Manabe Y, Abe K: Intellectual faculities in patients with Alzheimerfs disease regress to the level of a 4-5-year old child. Geriatr Gerontol Int 2: 143-147, 2002


  6. Abe K, Murakami T, Matsubara E, Manabe Y, Nagano I, Shoji M: Clinical features of CADASIL. Ann NY Acad Sci 977: 266-272, 2002


  7. Prat MI, Adamo AM, Gonzalez SA, Affranchino JL, Ikeda M, Matsubara E, Shoji M, Smith MA, Castano EM, Morelli L: Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein: relevance for neurodegeneration. Neurosci Lett 326: 9-12, 2002


  8. Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Arch 441: 58-67, 2002


  9. Matsubara E, Bryant-Thomas T, Pacheco J, enry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimerfs disease. J Neurochem 85: 1101-1108, 2003


  10. Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, Wolozin B, Sano M, Cruz-Sanchez FF, Thal LJ, Petanceska SS, Refolo LM: Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology 61: 199-205, 2003


  11. Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aβ homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004


  12. Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric Aβ rapidly accumulates in lipid rafts followed by ApoE and phosphorylated tau as memory is impaired in the Tg2576 mouse model of Alzheimerfs disease. J Neurosci 24: 3801-3809, 2004


  13. Murakami T, Shoji-M, Imai Y, Inoue H, KawarabayashiT, Matsubara E, Harigaya Y, SasakiA, Takahashi R, AbeK: Pael-R is accumulated in Lewy bodies of Parkinsonfs disease. Ann Neurol 55: 439-442, 2004


  14. Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25: 483-490, 2004


  15. Kurata T, Matsubara E, Yokoyama M, Nagano I, Shoji M, Abe K: Improvement of SSPE by intrathecal infusion of α-IFN. Neurology 63: 398-399, 2004


  16. Yamashita T, Matsubara E, Nagano I, Shoji M, Abe K: Bilateral extraocular muscle atrophy in myotonic dystrophy type 1. Neurology 63: 759-760, 2004


  17. Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Davies P, Chishti MA, Harigaya Y, Okamoto K, Abe K, Carlson GA, St.George-Hyslop P, Westaway D: Accumulation of Filamentous Tau in the Cerebral Cortex of Human Tau R406W Transgenic Mice. Am J Pathol 166: 521-531, 2005


  18. Matsubara E, Kurata T, Yokoyama M, Nagano I, Shoji M, Abe K: Improvement of SSPE by intrathecal infusion of α-IFN. Neurology 64: 402, 2005


  19. Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, Nishimura M: Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem 280: 19070-19077, 2005


  20. Matsubara E, Nagata T, Kageyama Y, Shiote M, Namba R, Nagano I, Shoji M, Abe K: Unique cerebellar-cerebral form of autosomal recessive ataxia. Tohoku J Exp Med 207: 81-85, 2005


@V@ixRȖȑwEwj
  1. Tada M, Aizawa T, Shinohara Y, Matsubara K, Miura K, Yoshida M, Shitara K, Kouno T, Mizuguchi M, Nitta K, Hayakawa Y, Kawano K: Role of aromatic residues in the structure and biological activity of the small cytokine, growth-blocking peptide (GBP). J Biol Chem 278: 10778-10783, 2003


  2. Matsubara K, Mizuguchi M, Kawano K: Expression of a synthetic gene encoding human transthyretin in Escherichia coli. Prot Expr Purif30: 55-61, 2003


  3. Mizuguchi M, Kroon GJ, Wright PE, Dyson HJ: Folding of a β-sheet protein monitored by real-time NMR spectroscopy. J Mol Biol 328: 1161-1171, 2003


  4. Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K: Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity. FEBS Lett 553: 232-238, 2003


  5. Shinohara Y, Mizuguchi M, Matsubara K, Takeuchi M, Matsuura A, Aoki T, Igarashi K, Terada Y, Kawano K: Biophysical analyses of the transthyretin variants, Tyr114His and Tyr116Ser, associated with familial amyloidotic polyneuropathy. Biochemistry 42: 15053-15060, 2003


  6. Kouno T, Mizuguchi M, Tanida I, Ueno T, Kominami K, Kawano K: Letter to the Editor : 1H 13C and 15N resonance assignments of human microtubule-associated protein light chain-3. J Biomol NMR 29: 415-416, 2004 


  7. Yoshida M, Aizawa T, Nakamura T, Shitara K, Hayakawa Y, Matsubara K, Miura K, Kouno T, Clark KD, Strand MR, Mizuguchi M, Demura M, Nitta K, Kawano K: The Gly-Gly linker region of the insect cytokine growth blocking peptide (GBP) is essential for activity. J Biol Chem 279: 51331-51337, 2004 


  8. Nakamura T, Takasugi H, Aizawa T, Yoshida M, Mizuguchi M, MoriY, Shinoda H, Hayakawa Y, Kawano K: Peptide mimics of epidermal growth factor (EGF) with antagonistic activity. J Biotechnol 116: 211-219, 2005


  9. Matsubara K, Mizuguchi M, Igarashi K, Shinohara Y, Takeuchi M, Matsuura A, Saitoh T, Mori Y, Shinoda H, Kawano K: Dimeric transthyretin variant assembles into spherical neurotoxins. Biochemistry 44: 3280-3288, 2005


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  1. Tamatani M, Mitsuda N, Matsuzaki H, Okado H, Miyake S, Vitek MP, Yamaguchi A Tohyama M: A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of NFκB and Bcl-2. J Neurochem 75: 683-693, 2000


  2. Hatanaka Y, Kamino K, Fukuo K, Mitsuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T: Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet 58: 319-323, 2000


  3. Tamatani M, Matsuyama T, Yamaguchi A, Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O, Nishimura H, Yamashita A, Okabe M, Yanagi H, Stern DM, Ogawa S, Tohyama M: ORP150 protects against hypoxia/ischemia-induced neuronal death. Nat Med 7: 317-323, 2001


  4. Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Ogihara T, Vitek MP, Tohyama M: Activated CREB regulates neuronal expression of presenilin-1. J Biol Chem 276: 9688-9698, 2001


  5. Matsuzaki H, Tamatani M, Yamaguchi A, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 15: 1218-1220, 2001


  6. Yamaguchi A, Tamatani M, Mitsuda N, Matsuzaki H, Vitek MP, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276: 5256-5264, 2001


  7. Ohkubo N, Mitsuda N, Tamatani M, Yamaguchi A, Lee Y-D, Ogihara T, Vitek MP, Tohyama M: Apolipoprotein E4 stimulates CREBfs transcriptional activity through the ERK pathway. J Biol Chem 276: 3046-3053, 2001


  8. Matsubara-Tsutsui M, Yamagata H, Morishima A, Nakura J, Mitsuda N, Kamino K, Kondo I, Miki T: The 4,752 C/T polymorphism in the presenilin 1 gene increases the risk of Alzheimerfs disease in apolipoprotein E4 carriers. Intern Med 41: 823-828, 2002


  9. Mori M, Nakagami H, Morishita R, Mitsuda N, Yamamoto K, Yoshimura S, Ohkubo N, Sato N, Ogihara T, Kaneda Y: N141I mutant presenilin-2 gene enhances neuronal cell death and decreases bcl-2 expression. Life Sci 70: 2567-2580, 2002


  10. Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Kawai Y, Senba E, Mitsuda N, Hori O, Yamaguchi A, Tohyama M: Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain. Mol Brain Res 100: 67-73, 2002


@ØY@iȑwiEwjEwj
  1. Mutoh T, Sobue G, Hamano T, Kuriyama M, Hirayama M, Yamamoto M, Mitsuma T: Decreased tyrosine phosphorylation of TrkB receptor in the spinal cords from the patients with amyotrophic lateral sclerosis. Neurochem Res 25: 239-245, 2000


  2. Hamano T, Mutoh T, Sugie H, Koga H, Kuriyama M: Phosphoglycerate kinase deficiency. An adult myopathic form with a novel mutation. Neurology 54: 1188-1190, 2000


  3. Kumano T, Mutoh T, Nakagawa H, Kuriyama M: HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, Trk, and morphological differentiation with fatal outcome in PC12 cells. Brain Res 859: 169-172, 2000


  4. Fukumoto S, Mutoh T, Hasegawa T, Miyazaki H, Okada M, Goto G, Furukawa K, Urano T, Furukawa K: GD3 synthase gene expression in PC12 cells resulted in the continuous activation of TrkA and ERK1/2, leading to enhanced proliferation. J Biol Chem 275: 5832-5838, 2000


  5. Hamano T, Miyoshi Y, Hirayama M, Hiraki S, Mutoh T, Kuriyama M: Posterior thoracic spinal cord infarction: Complication of thoracoabdominal aortic aneurysm. Eur Neurol 44: 59-60, 2000


  6. Mutoh T, Hamano T, Tokuda A, Kuriyama M: Unglycosylated Trk protein does not co-localize nor associate with gangliosides GM1 in stable clone overexpressing Trk of PC12 cells (PCtrk). Glycoconj J 17: 233-237, 2000


  7. Nakagawa H, Mutoh T, Kumano T, Kuriyama M: Tyrosine phosphorylation of the catalytic subunit p110 of phosphatidylinositol-3 kinase induced by HMG-CoA reductase inhibitor in L6 myoblasts. FEBS Lett 508: 53-56, 2001


  8. Hirayama M, Mutoh T, Tokuda A: Acid hydrolase activity of cultured bovine oligodendrocytes. Neurochem Res 26: 121-124, 2001


R@ɗY@isVlj
  1. Saito Y, Kawashima A, Fujiwara H, Ruberu NN, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropathol Exp Neurol 62: 644-654, 2003


  2. Saito Y, Ruberu NN, Harada M, Arai T, Sawabe M, Nukina N, Murayama S: In-situ detection of apolipoprotein E ε4 in archival human brain. NeuroReport 15: 1113-1115, 2004


  3. Ruberu NN, Saito Y, Honma N, Sawabe M, Yamanouchi H Murayama S: Granulomatous meningitis as a late complication of iodized oil myelography. Neuropathology 24: 144-148, 2004


  4. Saito Y, Suzuki K, Huelette C, Murayama S: Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease. J Neuropath Exp Neurol 63: 323-328, 2004


  5. Kazama H, Ruberu NN, Murayama S, Saito Y, Nakahara K, Kanemaru K, Nagura H, Arai T, Sawabe M, Yamanouchi H, Orimo H, Hosoi T: Association of estrogen receptor alpha-gene polymorphisms with neurofibrillary tangles. Dement Geriatr Cogn Disord 18: 145-150, 2004


  6. Saito Y, Ruberu NN, Sawabe M, Arai T, Kazama H, Hosoi T, Yamanouchi H Murayama S: Lewy body-related alpha-synucleinopathy in aging. J Neuropathol Exp Neurol 63: 742-749, 2004


  7. Sawabe M, Arai T, Kasahara I, Esaki Y, Nakahara K, Hosoi T, Orimo H, Takubo K, Murayama S, Tanaka N: Development of a geriatric autopsy database and internet-based database of Japanese single nucleotide polymorpisms for geriatric research (JG-SNP). Mech Aging Dev 125: 547-552, 2004


  8. Saito Y, Ruberu NN, Sawabe M, Arai T, Tanaka N, Kakuta Y, Yamanouchi H, Murayama S: Staging of argyrophilic grains, an age-associated tauopathy. J Neuropathol Exp Neurol 63: 911-918, 2004


  9. Murayama S, Saito Y: europathological diagnostic criteria for Alzheimer disease. Neuropathology 24: 254-260, 2004


  10. Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Murayama S, Kohriyama T, Katayama S, Yamashita M, Yamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M: Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease. Neurology 64: 643-648, 2004


  11. Katsuno T, Morishima-Kawashima M, Saito Y, Yamanouchi H, Ishiura S, Murayama S, Ihara Y: Independent accumulations of tau and amyloid β-protein in the human entorhinal cortex. Neurology 64: 687-692, 2005


  12. Ishigami A, Ohsawa T, Hiratsuka M, Taguchi H, Kobayashi S, Saito Y, Murayama S, Asaga H, Toda T, Kimura N, Maruyama N: Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimerfs disease. Neurosci Res 80: 120-128, 2005


i@W@iBwEwa@E_Ȑ_oȁj
  1. Hashioka S, Monji A, Ueda T, Kanba S, Nakanishi H: Amyloid-beta fibril formation is not necessarily required for microglial activation by the peptides. Neurochem Int 47: 369-376, 2005


R@@iQnwEwEیwȁj
  1. Yamaguchi H, Maat-Schieman ML, van Duinen SG, Prins FA, Neeskens P, Natte R, Roos RA: Amyloid β protein (Aβ) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol 59: 723-732, 2000


  2. Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, lhara Y: Effect of apolipoprotein E allel ε4 on the initial phase of amyloid β-protein accumulation in the human brain. Am J Pathol 157: 2093-2099, 2000


  3. Thal DR, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E: Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex. Acta Neuropathol 100: 608-617, 2000


  4. Kokubo H, Lemere CA, Yamaguchi H: Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology. Neurosci Lett 290: 93-96, 2000


  5. Tsuzuki K, Fukatsu R, Yamaguchi H, Tateno M, Imai K, Fujii N, Yamauchi T: Transthyretin binds amyloid β peptides, Aβ1-42 and Aβ1-40 to form complex in the autopsied human kidney-possible role of transthyretin for Aβ sequestration. Neurosci Lett 281: 171-174, 2000


  6. Fakla I, Kovacs I, Yamaguchi H, Geula C, Kasa P: Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat. Neurochem Int 36: 143-151, 2000


  7. Kasa P, Papp H, Kovacs I, Forgon M, Penke B, Yamaguchi H: Human amyloid-β1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. Neurosci Lett 278: 117-119, 2000


  8. Maat-Schieman ML, Yamaguchi H, van Duinen SG, Natte R, Roos RA: Age-related plaque morphology and C-terminal heterogeneity of amyloid β in Dutch-type hereditary cerebral hemorrhage with amyloidosis. Acta Neuropathol 99: 409-419, 2000


  9. Yamaguchi H, Sugihara S, Ogawa A, Ihara Y: Alzheimer β amyloid deposition, which is hastened by ApoE ε4 gene, precedes neurofibrillary pathology in the frontal association cortex of non-demented senior subjects. J Neuropathol Exp Neurol 60: 731-739, 2001


  10. Oshima N, Morishima-Kawashima M, Yamaguchi H, Yoshimura M, Sugihara S, Khan K, Games D, Schenk D, Ihara Y: Accumulation of amyloid β-protein in the low-density membrane domain accurately reflects the extent of β-amyloid deposition in the brain. Am J Pathol 158: 2209-2218, 2001


  11. Tanemura K, Akagi T, Murayama M, Kikuchi N, Murayama O, Hashikawa T, Yoshiike Y, Park J-M, Matsuda K, Nakao S, Sun X, Sato S, Yamaguchi H, Takashima A: Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau. Neurobiol Dis 8: 1036-1045, 2001


  12. Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy A, Takashima A: Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2002


  13. Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J. Biol. Chem 277: 12915-12920, 2002


  14. Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A: Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002


  15. Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H, Takashima A: Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 321: 61-64, 2002


  16. Thal DR, Ghebremedhin E, Rub U, Yamaguchi H, Tredici KD, Braak H: Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 61: 282-293, 2002


  17. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo H, Zheng H: The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci USA 99: 8760-8765, 2002


  18. Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK: Intraneuronal Alzneimer Abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161: 1869-1879, 2002


  19. Sasaki A, Horikoshi Y, Yokoo H, Nakazato Y, Yamaguchi H: Antiserum against human glucose transporter 5 is highly specific for microglia among cells of the mononuclear phagocyte system. Neurosci Lett 338: 17-20, 2003


  20. Horikoshi Y, Sasaki A, Taguchi N, Maeda M, Tsukagoshi H, Sato K, Yamaguchi H: Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections. Acta Neuropathol 105: 157-162, 2003


  21. Kokubo H, Helms J-B, Ohno-Iwashita Y, Shimada Y, Horikoshi Y, Yamaguchi H: Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res 965: 83-90, 2003


  22. Hashimoto N, Takeuchi T, Ishihara R, Ukai K, Kobayashi H, Iwata H, Iwai K, Mizuno Y, Yamaguchi H, Shibayama H: Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification. Acta Neuropathol 106: 150-156, 2003


  23. Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K,Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S: Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 22: 2913-2923, 2003


  24. Rofina J, van Andel I, van Ederen AM, Papaoiannou N, Yamaguchi H, Gruys E: Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid 10: 86-96, 2003


  25. Araki Y, Tomita S, Yamaguti H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid β-protein. J Biol Chem 278: 49448-49458, 2003


  26. Hayashi H, Kimura N, Yamaguchi H, Hasegawa K, Yokoseki T, Shibata M, Yamamoto N, Michikawa M, Yoshikawa Y, Terao K, Matsuzaki K, Lemere CA, Selkoe DJ, Naiki H, Yanagisawa K: A seed for Alzheimer amyloid in the brain. J Neurosci 24: 4894-4902, 2004


  27. Horikoshi Y, Sakaguchi G, Becker AG, Gray AJ, Duff K, Aisen PS, Yamaguchi H, Maeda M, Kinoshita N, Matsuoka Y: Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochem Biophys Res Commun 319: 733-737, 2004


  28. Taguchi N, Hatabu T, Yamaguchi H, Suzuki M, Sato K, Kano S: Plasmodium falciparum: selenium-induced cytotoxicity to P. falciparum. Exp Parasitol 106: 50-55, 2004


  29. Horikoshi Y, Mori T, Maeda M, Kinoshita N, Sato K, Yamaguchi H: Abeta N-terminal-end specific antibody reduced beta-amyloid in Alzheimer-model mice. Biochem Biophys Res Commun 325: 384-387, 2004


  30. Maat-Schieman ML, Yamaguchi H, Hegeman-Kleinn IM, Welling-Graafland C, Natte R, Roos RA, van Duinen SG: Glial reactions and the clearance of amyloid beta protein in the brains of patients with hereditary cerebral hemorrhage with amyloidosis-Dutch type. Acta Neuropathol 107: 389-398, 2004


  31. Sugiyama M, Ikeda E, Kawai S, Higuchi T, Zhang H, Khan N, Tomiyoshi K, Inoue T, Yamaguchi H, Katakura K, Endo K, Suzuki M: Cerebral metabolic reduction in severe malaria: fluorodeoxyglucose-positron emission tomography imaging in a primate model of severe human malaria with cerebral involvement. Am J Trop Med Hyg 71: 542-545, 2004


  32. Sasaki A, Yamaguchi H, Horikoshi Y, Tanaka G, Nakazato Y: Expression of glucose transporter 5 by microglia in human gliomas. Neuropathol Appl Neurobiol 30: 447-455, 2004


  33. Kokubo H, Saido TC, Iwata N, Helms JB, Shinohara R, Yamaguchi H: Part of membrane-bound Abeta exist in rafts within senile plaques in Tg2576 mouse brain. Neurobiol Aging 26: 409-418, 2005


  34. Kokubo H, Kayed R, Glabe CG, Yamaguchi H: Soluble Abeta oligomers ultrastructurally localize to cell processes and might be related to synaptic dysfunction in Alzheimerfs disease brain. Brain Res 1031: 222-228, 2005


  35. Kokubo H, Kayed R, Glabe CG, Saido TC, Iwata N, Helms JB, Yamaguchi H: Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain. Brain Res 1045: 224-228, 2005


R@M@iÉswEwj
  1. Ito J, Yokoyama S: Sialosylcholesterol induces reorganization of astrocyte filament network. Biochim Biophys Acta 1495: 195-202, 2000


  2. Zhang LY, Ito JI, Kato T, Yokoyama S: Cholesterol homeostasis in rat astrocytoma cells GA-1. J Biochem 128: 837-845, 2000


  3. Ito J, Nagayasu Y, Kato K, Sato R, Yokoyama S: Apolipoprotein A-I induces translocation of cholesterol, phospholipid and caveolin-1 to cytosol in rat astrocytes. J Biol Chem 277: 7929-7935, 2002


  4. Ueno S, Ito J, Nagayasu Y, Furukawa T, Yokoyama S: An acidic fibroblast growth factor-like factor secreted into the brain cell culture medium upregulates apoE synthesis, HDL secretion and cholesterol metabolism in rat astrocytes. Biochim Biopys Acta 1589: 261-272, 2002


  5. Ito J, Nagayasu Y, Ueno S, Yokoyama S: Apolipoprotein-mediated cellular lipid release requires replenishment of sphingomyelin in a phosphatidylcholine-specific phospholipase C-dependent manner. J Biol Chem 277: 44709-44714, 2002


aI@@iwEw@wnȁj
  1. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y: Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci 20: 6898-6906, 2000


  2. Waguri S, Kohmura M, Kanamori S, Watanabe T, Ohsawa Y, Koike M, Tomiyama Y, Wakasugi M, Kominami E, Uchiyama Y: Different distribution patterns of the two mannose 6-phosphate receptors in rat liver. J Histochem Cytochem 49: 1397-1405, 2001


  3. Shibata M, Koike M, Waguri S, Zhang G, Koga T, Uchiyama Y: Cathepsin D is specifically inhibited by deoxyribonucleic acids. FEBS Lett 517: 281-284, 2002


  4. Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K: Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. Biochem Biophys Res Commun 294: 254-260, 2002


  5. Koike M, Shibata M, Ohsawa Y, Kametaka S, Waguri S, Kominami E, Uchiyama Y: The expression of tripeptidyl peptidase I in various tissues of rats and mice. Arch Histol Cytol 65: 219-232, 2002



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