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  1. Ohkubo T, Sakasegawa Y, Asada T, Kinoshita T, Goto Y, Kimura H, Mizusawa H, Hachiya NS, Kaneko K: Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimerfs disease in Japan. Ann Neurol 54: 553-554, 2003


  2. Matsuda H, Ohnishi T, Asada T, Zhi-jie Li, Kanetaka H, Imabayashi E, Tanaka F, Nakano S: Correction for partial-volume effects on brain perfusion SPECT in healthy men. J Nucl Med 44: 1243-1252, 2003


  3. Sakamoto S, Matsuda H, Asada T, Ohnishi T, Nakano S, Kanetaka H, Takasaki M: Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study. J Neuroimaging 13: 113-123, 2003


  4. Tanaka N, Kinoshita T, Asada T, Ohashi Y: Long-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein E (apoE) gene in Alzheimerfs disease. J Hum Genet 48: 520-524, 2003


  5. Sakasegawa Y, Kishida H, Sakurai M, Asada T, Kinoshita T, Goto Y, Kimura H, Kuroiwa Y, Hachiya NS, Kaneko K: Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimerfs disease in a Japanese population. Neurosci Lett 353: 49-52, 2003


  6. Yamaguchi M, Suzuki T, Seki T, Namba T, Juan R, Arai H, Hori T, Asada T: Repetitive cocaine administration decreases neurogenesis in adult rat hippocampus. Ann NY Acad Sci 1025: 351-362, 2003


  7. Zhi-Jie L, Matsuda H,Asada T, Ohnishi T, Kanetaka H, Imabayashi E, Tanaka F: Gender difference in brain perfusion 99m-ECD SPECT in aged healthy volunteers after correction for partial volume effects. Nucl Med Commun 25: 999-1005, 2004


  8. Imabayashi E, Matsuda H, Asada T, Ohnishi T, Sakamoto S, Nakano S, Inoue T: Superiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimerfs disease from controls using brain perfusion SPECT. J Nucl Med 45: 1450-1457, 2004


  9. Kanetaka H, Matsuda H, Asada T, Ohnishi T, Yamashita F, Tanaka F, Nakano S, Takasaki Y: Effects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT. Eur J Nucl Med Mol Imaging 31: 975-980, 2004


  10. Tanahashi H, Asada T, Tabira T: Association between tau polymorphism and male early-onset Alzheimerfs disease. NeuroReport 15: 175-180, 2004


  11. Ishikawa M, Mizukami K, Iwakiri M, Hidaka S, Kamma H, AsadaT: Alterations of heterogeneous nuclear RNP A2 and B1 in the hippocampus of the rat after perforant pathway lesion. Acta Neuropathol 107: 144-148, 2004


  12. Cichocki A, Shishkin SL, Musha T, Leonowicz Z, Asada T, Kurachi T: EEG fitering based on blind source separation (BSS) for early detection of Alzheimerfs disease. Clin Neurophysiol 116: 729-737, 2005


  13. Tamura Y, Sakasegawa Y, Omi K, Kishida H, Asada T, Kimura H, Tokunaga K, Hachiya NS, Kaneko K, Hohjoh H: Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population. Neurosci Lett 379: 149-151, 2005


  14. Hirata Y, Matsuda H,Nemoto K, Ohnishi T, Hirano K, Yamashita F, Asada T, Iwabuchi S, Samejima H: Voxel-based morphometry to discriminate early Alzheimerfs disease from controls. Neurosci Lett 382: 269-274, 2005


  15. Iwakiri M, Mizukami K, Ikonomovic MD, Ishikawa M, Hidaka S, Abrahamson EE, Dekosky ST, Asada T: Changes in hippocampal GABA(B)R1 subunit expression in Alzheimerfs patients: association with Braak staging. Acta Neuropathol 109: 467-474, 2005


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  1. Nakagawa T, Sekizawa K, Kosaka Y, Arai H, Sasaki H: Silent cerebral infarction: a potential risk for pneumonia in the elderly. J Intern Med 247: 255-259, 2000


  2. Nakajoh K, Nakagawa T, Sekizawa K, Matsui T, Arai H, Sasaki H: Relation between incidence of pneumonia and protective reflexes in post-stroke patients with oral and tube feeding. J Intern Med 247: 39-42, 2000


  3. Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, Itoh M, Shin R-W, Trojanowski JQ, Sasaki H: Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 162: 247-256, 2000


  4. Wang Q, Iwasaki K, Suzuki T, Arai H, Ikarashi Y, Yabe T, Toriizuka K, Hanawa T, Yamada H, Sasaki H: Potentiation of brain acethylcholine neurons by Kami-Untan-To (KUT) in aged mice: Implication for a possible antidementia drug. Phytomedicine 7: 253-258, 2000


  5. Iwasaki K, Wang Q, Seki H, Satoh K, Takeda A, Arai H, Sasaki H: The effects of the traditional Chinese medicine gBanxia Houpo Tang (Hange-Koboku To)h on the swallowing reflex in Parkinsonfs disease. Phytomedicine 7: 259-263, 2000


  6. Saito Y, Kawai M, Inose K, Sasaki R, Arai H, Namba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S: Widespread expression of a-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. J Neurol Sci 177: 48-59, 2000


  7. Matsui T, Usuda N, Arai H, Nakazawa A, Matsushita S, Higuchi S, Sasaki H: Rapid non-radioactive in-situ hybridization for mRNA detection of calcineurin in rat brain using PCRDNA probe. Acta Histochem Cytochem 33: 115-122, 2000


  8. Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: a2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimerfs disease. NeuroReport 11: 1167-1171, 2000


  9. Arai H. Ishiguro K, Ohno H, Moriyama M, Itoh N, Okamura N, Matsui T, Morikawa Y, Hirikawa E, Kohno H, Sasaki H, Imahori K: CSF phosphorylated tau protein and mild cognitive impairment: A prospective study. Exp Neurol 166: 201-203, 2000


  10. Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H: NOS3 polymorphism not associated with Alzheimerfs disease in Japanese. Ann Neurol 48: 685, 2000


  11. Hu XS, Okamura N, Arai H, Higuchi M, Matsui T, Shinkawa M, Itoh M, Ido T, Sasaki H: 18F-DOPA PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodies. Neurology 55: 1575-1576, 2000


  12. Higuchi S, Yoshino A, Matsui T, Matsushita S, Satoh A, Iimura T, Ishikawa M, Arai H, Shirakura K: A novel PS1 mutation (W165G) in a Japanese family with early-onset Alzheimerfs disease. Alz Rep 3: 227-231, 2000


  13. Kimpara T, Takeda A, Yamaguchi T, Arai H, Okita N, Takase S, Sasaki H, Itoyama Y: Increased bilirubins and their derivatives in cerebrospinal fluid in Alzheimerfs disease. Neurobiol Aging 21: 551-554, 2000


  14. Ikeda K, Urakami K, Arai H, Wada K, Wakutani Y, Ji Y, Adachi A, Kowa H, Sasaki H, Ohno K, Ohtsuka Y, Ishikawa Y, Nakashima K: The expression of presenilin-1 mRNA in skin fibroblasts and brains from sporadic Alzheimerfs disease. Dement Geriatr Cogn Disord 11: 245-250, 2000


  15. Higuchi M, Yanai K, Okamura N, Meguro K, Arai H, Itoh M, Iwata R, Ido T, Watanabe T, Sasaki H: Histamine H1 receptors in patients with Alzheimerfs disease assessed by positron emission tomography. Neuroscience 99: 721-729, 2000


  16. Manabe K, Matsui T, Yamaya M, Sato-Nakagawa T, Okamura N, Arai H, Sasaki H: Sleep patterns and mortality among elderly patients in geriatric hospital. Gerontology 46: 318-322, 2000


  17. Kanda A, Ebihara S, Arai H, Takeda A, Sasaki H: Parkinsonfs disease and impaired chemosensitivity to hypoxia. Lancet 356: 2099-2100, 2000


  18. Kimura M, Matsushita S, Arai H, Matsui T, Yuzuriha T, Higuchi S: No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimerfs disease in Japanese. J Neural Transm 107: 1449-1456, 2000


  19. Okamura N, Hu X-S, Arai H, Maruyama M, Higuchi M, Tashiro M, Matsui T, Itoh M, Sasaki H: Assessment of nitrostriatal dopaminergic function in patients with dementia with Lewy bodies. CYRIC Ann Rep: 116-118, 2000.


  20. Okamura N, Arai H, Higuchi M, Tashiro M, Maruyama M, Matsui T, Hu X-S, Itoh M, Sasaki H: Regional glucose hypometabolism in brain nof patients with dementia with Lewy bodies and Alzheimerfs disease. CYRIC Ann Rep: 119-122, 2000


  21. Matsui T, Morikawa Y, Tojo M, Okamura N, Maruyama M, Hirai H, Chiba H, Matsushita S, Higuchi S, Arai H, Sasaki H: Cathepsin D polymorphism not associated with Alzheimerfs disease in Japanese. Ann Neurol 49: 544-545, 2001


  22. Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Hu X-S, Takeda A, Itoh M, Sasaki H: [18F]FDG-PET study in dementia with Lewy bodies and Alzheimerfs disease. Prog Neuropsychopharmacol Biol Psychiat 25: 447-456, 2001


  23. Matsui T, Arai H, Yuzuriha T, Yao H, Miura M, Hashimoto S, Higuchi S, Matsushita S, Morikawa M, Kato A, Sasaki H: Elevated plasma homocysteine levels and a risk for silent brain infarction in elderly people. Stroke 32: 1116-1119, 2001


  24. Wada H, Nakajoh K, Satoh-Nakagawa T, Suzuki T, Ohrui T, Arai H, Sasaki H: Risk factors of aspiration pneumonia in Alzheimerfs disease patients. Gerontology 47: 271-276, 2001


  25. Matsushita S, Arai H, Yuzuriha T, Kato M, Matsui T, Urakami K, Higuchi S: No association between DLST gene and Alzheimerfs disease or Wernicke-Korsakoff syndrome. Neurobiol Aging 22: 569-574, 2001


  26. Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido CT: Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci 13: 1-15, 2001


  27. Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of Apolipoprotein E mRNA in the brains with sporadic Alzheimerfs disease. Dement Geriatr Cogn Disord 12: 57-62, 2001


  28. Kimura M, Matsushita S, Arai H, Takeda A, Higuchi S: No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinsonfs disease. Ann Neurol 49: 276-277, 2001


  29. Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller H-J, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multi-center study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimerfs disease. Ann Neurol 50: 150-156, 2001


  30. Okamura N, Arai H, Maruyama M, Matsui T, Tanji H, Yoshida H, Sugita M, Sasaki H: Serum cholesterol and cerebrospinal fluid amyloid β protein in Alzheimerfs disease. J Am Geriatr Soc 49: 1738-1739, 2001


  31. Takeda M, Tanaka T, Arai H, Sasaki H, Shiji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid1-42 in cerebrospinal fluid as a diagnostic marker for Alzheimerfs disease and related disorders: Multi-center study in Japan. Psychogeriatrics 1: 56-63, 2001


  32. Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikase C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001


  33. Nakazawa A, Usuda N, Matsui T, Hanai T, Matsushita S, Arai H, Sasaki H, Higuchi S: Localization of calcineurin in the mature and developing retina. J Histochem Cytochem 49: 187-195, 2001


  34. Maruyama M, Arai H, Sugita M, Tanji H, Higuchi M, Okamura N, Matsui T, Higuchi S, Matsushita S, Yoshida H, Sasaki H: Cerebrospinal fluid amyloid β1-42 in the mild cognitive impairment stage of Alzheimerfs disease. Exp Neurol 172: 433-436, 2001


  35. Sato E, Ohrui T, Matsui T, Arai H, Sasaki H: Folate deficiency and risk of pneumonia in older people. J Am Geriatr Soc 49: 1739-1740, 2001


  36. Yamaya M, Yanai M, Ohrui T, Arai H, Sekizawa K, Sasaki H: Antithrombotic therapy for prevention of pneumonia. J Am Geriatr Soc 49: 687-688, 2001


  37. Suzuki T, Arai H, Iwasaki K, Tanji H, Higuchi M, Okamura N, Matsui T, Maruyama M, Yabe T, Toriizuka K, Yamada H, Hanawa T, Ikarashi Y, Sasaki H: A Japanese herbal medicine (Kami-Untan-To) in the treatment of Alzheimerfs disease: A pilot study. Alz Rep 4: 177-182, 2001


  38. Yamagata K, Wakutani Y, Urakami K, Wada K, Arai H, Sasaki H, Higuchi S, Sato K, Nakashima K: Apolipoprotein E promotor -186G/T polymorphism and Japanese Alzheimerfs disease. Alz Rep 4: 161-165, 2001


  39. Wakutani Y, Ito T, Wada K, Yamagata K, Adachi Y, Taniguchi M, Arai H, Sasaki H, Higuchi S, Sato K, Urakami K, Nakashima K: Identification of aberrant tau mRNA in brain tissue. Alz Rep 4: 145-150, 2001


  40. Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol 52: 501-509, 2001


  41. Tashiro M, Itoh M, Kubota K, Kumano H, Masud MM, Moser EM, Arai H, Sasaki H: Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary PET study. Psycho-Oncology 10: 541-546, 2001


  42. Okamura N, Arai H, Maruyama M, Higuchi M, Matsui T, Tanji H, Seki T, Hirai H, Chiba H, Itoh M, Sasaki H: Combined analysis of CSF-tau and [123I]Iodoamphetamine-SPECT in mild cognitive impairment: Implications for a novel predictor of Alzheimerfs disease. Am J Psychiat 159: 474-476, 2002


  43. Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi K, Matsui T, Maruyama M, Iwatsubo T, Higuchi S: Clinical and bio-marker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild impairment stage of Alzheimerfs disease. Biol Psychiat 52: 907-1910, 2002


  44. Buerger K, Zinkowski R, Teipel SJ, Tapiola T, Arai H, Blennow K, Andreasen N, Hofmann-Kiefer K, DeBernardis J, Kerkman D, McCulloch C, Kohnken R,Padberg F, Pirttilä P, Schapiro MB, Rapoport SI, Möller H-J, Davies P, Hampel H: Differential diagnosis of Alzheimerfs disease with CSF tau proteinphosphorylated at threonine 231. Arch Neurol 59: 1267-1272, 2002


  45. Ebihara T, Yamaya M, Ohrui T, Arai H, Sasaki H: Comparison of disabled older people in the USA and Japan. Geriatr Gerontol Int 2: 53-56, 2002


  46. Ohrui T, Arai H, Ichinose M, Matsui T, Yamaya M, Sasaki H: Relationship between asthma severity and progression of Alzheimerfs disease. Thorax 57: 561, 2002


  47. Matsui T, Yamaya M, Ohrui T, Arai H, Sasaki H: Sitting position to prevent aspiration in bed-ridden patients. Gerontology 48: 194-195. 2002


  48. Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Fujii T, Komemushi S, Itoh M, Sasaki H, Watanabe T, Yanai K: Differential cognitive effects of ebastine and (+)-chorphenilamine in healthy subjects: correlation between cognitive impairment and plasma drug concentrations. Br J Clin Pharmacol 53: 296-304, 2002


  49. Hu XiaSheng, Okamura N, Arai H, Higuchi M, Maruyama M, Itoh M, Yamaguchi K, Sasaki H: Neuroanatomical correlates of low body weight in Alzheimerfs disease. Prog Neuropsychopharmacol Biol Psychiat 26: 1285-1289, 2002


  50. Buerger K, Teipel SJ, Zinkowski R, Blennow K, Arai H, Engel R, Hofman K: CSF-tau protein phosphorylated at threonine 231 correlates with cognitive decline in MCI subjects. Neurology 59: 627-629, 2002


  51. Li JQ, Jia YX, Yamaya M, Arai H, Ohrui T, Sekizawa T, Sasaki H: Neurochemical regulation of cough response to capsaicin in guinea-pig. Auton Autacoid Pharmacol 22: 57-63, 2002


  52. Ohara S, Tsuyuzaki J, Oide T, Arai H, Higuchi S, Hasegawa M, Iwatsubo T: A clinical and neuropathologcal study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration? Neurosci Lett 300: 84-88, 2002


  53. Shinkawa M, Yamaya M, Ohrui T, Arai H, Sasaki H: Depression in older people. Geriatr Gerontol Int 2: 215-216, 2002


  54. Maruyama M, Arai H, Okamura N, Matsui M, Sasaki H: Biomarkers in subjects with amnestic mild cognitive impairment. J Am Geriatr Soc 51: 1671-1672, 2003


  55. Arai H, Matsui T, Maruyama M, Okamura N, Sasaki H: Classification of dementias. Lancet 361: 1227-1228, 2003


  56. Kanda A, Matsui T, Ebihara S, Arai H, Sasaki H: Periventricular white matter lesions and sleep alternation in older people. J Am Geriatr Soc 51: 432-433, 2003


  57. Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinsonfs disease. Ann Neurol 54: 276-277, 2003


  58. Seki T, Kurusu M, Haruko Tanji, Arai H, Sasaki H: Acupuncture and swallowing reflex in poststroke patients. J Am Geriatr Soc 51: 726-727, 2003


  59. Buerger K, Zinkowski R, Teipel SJ, Arai H, DeBernardis J, Kerkman D: Differentiation between geriatric major depression and Alzheimerfs disease with CSF tau protein phosphorylated at threonine 231. Am J Psychiat 160: 376-379, 2003


  60. Clark CM, Ewbank D, Peskind E, Galasko D, Morris JC, Farlow M, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, DeCarli C, Leight S, Lee VM-Y, Trojanowski JQ: Cerebrospinal fluid tau and β-amyloid: How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Arch Neurol 60: 1696-1702, 2003


  61. Itoh N, Ishiguro K, Arai H, Kokubo Y, Sasaki R, Narita Y, Kuzuhara S: Biochemical and ultrastructual study of neurofibrillary tangles in amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii peninsula of Japan. J Neuropathol Exp Neurol 62: 791-798, 2003


  62. Matsui T, Arai H, Nakajo M, Maruyama M, Ebihara S, Sasaki H, Yoshida Y: Role of chronic sinusitis in cognitive functioning in the elderly. J Am Geriatr Soc 51: 1818-1819, 2003


  63. Kosaka Y, Satoh-Nakagawa T, Ohrui T, Yamaya M, Arai H, Sasaki H: Tube feeding in terminal care. Geriatr Gerontol Int 3: 172-174, 2003


  64. Ebihara S, Saito H, Kanda A, Nakajoh M, Takahashi H, Arai H, Sasaki H: Impaired efficacy of cough in patients with parkinsonfs disease. Chest 124: 1009-1015, 2003


  65. Okamura N, Maruyama M, Ebihara T, Arai H, Sasaki H: Aspiration pneumonia and insular hypoperfusion in patients with cerebrovascular disease. J Am Geriatr Soc 52: 645-646, 2004


  66. Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H. Cyong J-C, Sasaki H: A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine Ba Wei Di Huang Wan in the treatment of dementia. J Am Geriatr Soc 52: 1518-1521, 2004


  67. Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, Sasaki H, Kudo Y, Sawada T: Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci 24: 2535-2541, 2004


  68. Okamura N, Suemoto T, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Arai H, Sasaki H, Yanai K, Staufenbiel M, Kudo Y, Sawada T: A novel imaging probe for in vivo detection of neuritic and duffuse plaques in the brain. J Mol Neurosci 24: 247-256, 2004


  69. Maruyama M, Matsui T, Tanji H, Memoto M, Tomita N, Ootsuki M, Arai H, Sasaki H: Cerebrospinal fluid tau protein and periventricular white matter lesions in aging, stable and progressive mild cognitive impairment: Implications for two major pathways. Arch Neurol 61: 716-720, 2004


  70. Ohrui T, Matsui T, Yamaya M, Arai H, Ebihara S. Maruyama M, Sasaki H: Angiotensin converting enzyme inhibitors and incidence of Alzheimerfs disease in Japan. J Am Geriatr Soc 52: 649-650, 2004


  71. Seki T, Kurusu M, Arai H, Sasaki H: Acupuncture for gait disorders in the elderly. J Am Geriatr Soc 52: 643-644, 2004


  72. Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H, Cyong J-C, Sasaki H: Effects of the Chinese herbal medicine gBa Wei Di Huang Wanh in the reatment of dementia: A SPECT cerebral blood flow examination and a randomized, double-blind, placebo-controlled clinical trial for cognitive function and ADL. Geriatr Gerontol Int 4: S124-128, 2004


  73. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund L-O, Nordberg A, Backman L, Albert M, Almkvist O, Arai H, Basun H, Blennow K, De Leon M, DeCarli C, Erkinjuntti T, Giacobini E, Graff C, Hardy J, Jack A, Jorm A, Richie K, Van Dubin C, Visser P, Petersen RC: Mild cognitive impairment-beyond controversies towards consensus: report of the international working group on Mild cognitive impairment. J Intern Med 256: 240-246, 2004


  74. Kikuchi A, Takeda A, Fujihara K, Kimpara T, Shiga Y, Tanji H, Nagai M, Ichinose H, Urano F, Okamura N, Arai H, Itoyama Y: Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: A case report. Mov Disord 19: 590-593, 2004


  75. Horikawa E, Okamura N, Tashiro M, Sakurada Y, Maruyama M, Arai H, Yamaguchi K, Sasaki H, Yanai K, Itoh M: The neural correlates of driving performance identified using positron emission tomography. Brain Cogn 58: 166-171, 2004


  76. Nakagawasai O, Yamadera F, Iwasaki K, Arai H, Taniguchi R, Tan-no K, Sasaki H, Tadano T: Effect of Kami-Untan-To on the impairment of leaning and memory induced by thiamine-deficient feeding in mice. Neuroscience 125: 233-241, 2004


  77. Ohrui T, Tomita N, Satoh-Nakagawa T, Matsui T, Maruyama M, Niwa K, Arai H, Sasaki H: Effects of brain-penetrating ACE inhibitors on Alzheimerfs disease progression. Neurology 63: 1324-1325, 2004


  78. Iwasaki K, Satoh-Nakagawa T, Maruyama M, Monma Y, Nemoto M, Tomita N, Tanji H, Fujiwara H, Seki T, Fujii M, Arai H, Sasaki H: A randomized observer-blind controlled trial of a traditional chinese medicine, Yi-Gan San, on behavioral and psychological symptoms and activities of daily living in dementia patients. J Clin Psychiat 66: 248-252, 2005


  79. Tanji H, Ootsuki M, Matsui T, Maruyama M, Nemoto M, Tomita N, Seki T, Iwasaki K, Arai H, Sasaki H: Caregiverfs burden and use of public services among dementia caregivers. Geriatr Gerontol Int 5F94-98, 2005


  80. Arai H, Maruyama M: The heterogeneity and natural history of mild cognitive impairment. Arch Neurol 62: 163-164, 2005


  81. Yamada M, Ohrui T, Asada M, Ishizawa K, Ebihara S, Arai H, Sasaki H: Acarbose attenuates hypoglycemia from dumping syndrome in an elderly man with gastrectomy. J Am Geriatr Soc 53: 58-359, 2005


  82. Mochizuki H, Masaki T, Matsushita S, Ugawa Y, Kamakura K, Arai H, Motoyoshi K, Higuchi S: Cognitive impairment and diffuse white matter atrophy in alcoholics. Clin Neurophysiol 116: 223-228, 2005


  83. Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimerfs disease. J Neural Transms 112: 703-711, 2005


  84. Hamaguchi T, Kitamoto T, Sato T, Mizusawa H, Nakamura Y, Noguchi M, Furukawa Y, Ishida C, Kuji I, Mitani K, Kurayama S, Kohriyama T, Katayama S, Yamashita M, Mamamoto T, Udaka F, Kawakami A, Ihara Y, Nishinaka T, Kuroda S, Suzuki N, Shiga Y, Arai H, Maruyama M, Yamada M: Clinical diagnosis of MM2-type sporadic Creutzfeldt-Jakob disease. Neurology 64: 643-648, 2005


  85. Seki T, Iwasaki K, Arai H, Sasaki H, Hayashi H, Yamada S, Toba K: Acupuncture for dysphasia in poststroke patients: A videofluoroscopic study. J Am Geriatr Soc 53: 1083-1084, 2005


V@@iVwEwj
  1. Maruyama H, Toji H, Harrington CR, Sasaki K, Izuka Y, Ohnuma T, Arai H, Yasuda M, Tanaka C, Emson PC, Nakamura S, Kawakami H: Lack of an association of estrogen reseptor α gene polymorphisms and transcriptional activity with Alzheimerfs Disease. Arch Neurol 57: 236-240, 2000


  2. Shibata N, Ohnuma T, Takahasi T, Ohtsuka E, Ueki A, Nagao M, Arai H: No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimerfs disease. Neurosci Lett 290: 154-156, 2000


  3. Ishizuka TCBaba H, Higashi H, Arai H: Circulating natural killer cell activity and cytokine production in Alzheimerfs disease. Alz Rep 4: 81-85, 2001


  4. Higashi H, Ohnuma T, Shibata N, Ishizuka T, Higashi M, Ohtuka E, Ueki A, Nagao M, Arai H: Association of transforming growth factor-β1 gene polymorphisms in Japanese sporadic Alzheimerfs disease. Alz Rep 5: 21-24, 2002


  5. Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet 114: 436-439, 2002


  6. Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer's disease. Neurosci Lett 323: 161-163, 2002


  7. Matsubara Y, Ohnuma T, Shibata N, Takahashi T, Arai H: Plasma concentration of risperidone showed a correlation with daily dose,but not with age nor cytochrome P-450 2D6 gene polymorphisms in Japanese schizophrenics. Psychogeriatrics 2: 284-288, 2002


  8. Ohnuma T, Shibata N, Matsubara Y, Arai H: Haloperidol plasma concentration in Japanese psychiatric subjects with gene duplication of CYP2D6. Br J Clin Pharmacol 56: 315-320, 2003


A؁@@iȑwE{ÃZ^[j
  1. Kamino K, Nagasaka K, Yamamoto H, Yoneda H, Miki T, Imagawa M, Ueki A, Kitamura S, Namekata K, Ohta S: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in Japanese population. Biochem Biophys Res Commun 273: 192-196, 2000


  2. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: Alzheimer's disease and 5-HTTLRP polymorphism of the serotonin transporter gene: No evidence for an association. Am J Med Genet 96: 307-309, 2000


  3. Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimerfs disease. J Neural Transm 107: 1081-1084, 2000


  4. Shibata N, Ohnuma T, Takahashi T, Otsuka E, Ueki A, Nagao M, Arai H: No genetic association between α-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimerfs disease. Neurosci Lett 290: 154-156, 2000


  5. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabita T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiat 6: 83-86, 2001


  6. Shibata N, Ohnuma T, Takahasi T, Baba H, Ishizuka T, Otsuka M, Ueki A, Nagao M, Arai H: The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimerfs disease. Neurosci Lett 323: 161-163, 2002


  7. Shibata N, Ohnuma T, Takahashi T, Baba H, Ishizuka T, Ohtsuka M, Ueki A, Nagao M, Arai H: Effect of IL-6 polymorphism on risk of Alzheimer disease: genotype-phenotype association study in Japanese cases. Am J Med Genet 114: 436-439, 2002


Y@@iwEwj
  1. Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Downfs syndrome. Alz Rep 3: 77-82, 2000


  2. Urakami K, Wada-Isoe K, Wakutani Y, Ikeda K, Ji Y, Yamagata K, Kowa H, Okada A, Adachi Y, Nakashima K: Lipoprotein(a) phenotypes in patients with vascular dementia. Dement Geriatr Cogn Disord 11: 135-138, 2000


  3. Ikeda K, Urakami K, Arai H, Wada K, Wakutani Y, Ji Y, Adachi Y, Okada A, Kowa H, Sasaki H, Ohno K, Ohtsuka Y, Ishikawa Y, Nakashima K: The expression of presenilin 1 mRNA in skin fibroblasts and brains from sporadic Alzheimerfs disease. Dement Geriatr Cogn Disord 11: 245-250, 2000


  4. Ji Y, Urakami K, Wada-Isoe K, Adachi Y, Nakashima K: Estrogen receptor gene polymorphisms in patients with Alzheimerfs disease, vascular dementia and alcohol-associated dementia. Dement Geriatr Cogn Disord 11: 119-122, 2000


  5. Kowa H, Yasui K, Takeshima T, Urakami K, Sakai F, Nakashima K: The homozygous C677T mutation in the methylenetetrahydrifolate reductase gene is a genetic risk factor for migraine. Am J Med Genet 96: 762-764, 2000


  6. Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: α2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimerfs disease. NeuroReport 11: 1167-1171, 2000


  7. Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimerfs disease. Dement Geriatr Cogn Disord 12: 57-62, 2001


  8. Higuchi S, Ohta S, Matsushita S, Matsui T, Yuzuriha T, Urakami K, Arai H: NOS3 polymorphism not associated with Alzheimerfs disease in Japanese. Ann Neurol 48: 685, 2000


  9. Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid (1-42) in cerebrospinal fluid as a diagnostic marker for Alzheimerfs disease and related disorders: multi center study in Japan. Psychogeriatrics 1: 56-63, 2001


  10. Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller HJ, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimerfs disease. Ann Neurol 50: 150-156, 2001


  11. Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K. Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001


  12. Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002


  13. Wakutani Y, Kowa H, Kusumi M, Yamagata K, Wada-Isoe K, Adachi Y, Takeshima T, Urakami K, Nakashima K: Genetic analysis of vascular factors in Alzheimerfs disease. Ann NY Acad Sci 977: 232-238, 2002


  14. Watanabe Y, Shimizu Y, Urakami K, Matsushima E, Nakashima K: Vertical ophthalmoplegia in a demented patient with striatopallidodentate calcification. Psychiat Clin Neurosci 57: 447|450C2003


  15. Inoue M, Suyama A, Kato T, Urakami K, Nakashima K, Meshitsuka S: Development of computerized Kana pick out test for the neuropsychological examination. Comput Methods Programs Biomed 70: 271-276, 2003


  16. Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y, Mori M, Kawashima M, Kowa H, Adachi Y, Urakami K, Nakashima K: Population based door-to-door survey of migraine in Japan: the Daisen study. Headache 44: 8-19, 2004


  17. Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimerfs disease. Dement Geriatr Cogn Disord 17: 147-150, 2004


  18. Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimerfs disease. Neurobiol Aging 25: 291-294, 2004


  19. Wakutani Y, Watanabe K, Adachi Y, Isoe-Wada K, Urakami K, Ninomiya H, Hashimoto H, Saido TC, Iwatsubo T, Nakashima K: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimerfs disease. J Neurol Neurosurg Psychiat 75: 1039-1042, 2004


  20. Wada-Isoe K, Wakutani Y, Urakami K, Nakashima K: Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients. Acta Neurol Scand 110: 124-127, 2004


  21. Hattori S, Sakuma K, Wakutani Y, Wada K, Shimoda M, Urakami K, Kowa H, Nakashima K: A novel presenilin 1 mutation (Y154N) in a patient with early onset Alzheimerfs disease with spastic paraparesis. Neurosci Lett 368: 319-322, 2004


  22. Urakami K: Vascular factors in Alzheimerfs disease. Psychogeriatrics 4: 123-125, 2004


  23. Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aβ homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004


  24. Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimerfs diseaseDJ Neural Transm 112: 703-771, 2005


  25. Urakami K: Early diagnostic marker for Alzheimerfs disease. World J Biol Psychiat 6: 46, 2005


c@j@i{ȑwEVlaj
  1. Asoh S, Ohtsu T, Ohta, S: The Super anti-apoptotic factor Bcl-xFNK constructed by disturbing intramolecular polar interactions in rat Bcl-xL. J Biol Chem 275: 37240-37245, 2000


  2. Hatanaka Y, Kamino K, Fukuo K, Mistuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T: Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimerfs disease in a Japanese population. Clin Genet 58: 319-323, 2000


  3. Yasukawa T, Hino T, Suzuki T, Watanabe K, Ueda T, Ohta S: A pathogenic point mutation reduces stability of mitochondrial mutant tRNAlle. Nucl Acids Res 28: 3779-3784, 2000


  4. Kamino K, Nagasaka K, Imagawa M, Yamamoto H, Yoneda H, Ueki A, Kitamura S, Namekata K, Miki T, Ohta S: Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimerfs disease in the Japanese population. Biochem Biophys Res Commun 273: 192-196, 2000


  5. Nanbu-Wakao R, Asoh S, Nishimaki K, Tanaka R, Ohta S: Bacterial cell death induced by human pro-apoptotic Bax is blocked by an RNaseE mutant that functions in an anti-oxidant pathway. Genes Cells 5: 155-167, 2000


  6. Yamada M, Mizuguchi M, Nishimaki K, Takasima S, Ikeda K, Ohta S, Takahashi H: Localization of Bcl-xβ in the developing and adult rat central nervous system. J Neurosci Res 60: 468-477, 2000


  7. Tanabe T, Takata I, Kuwabara T, Warashina M, Kawasaki H, Tani K, Ohta S, Asano S, Taira K: Maxizymes, Novel allosterically controllable ribozymes, can be designed to cleave various substrates. Biomacromolecules 1: 108-117, 2000


  8. Yasukawa T, Suzuki T, Suzuki Ta, Ueda T, Ohta S, Watanabe K: Modification defect at anticodon wobble nucleotide of mitochondrial tRNAsLeu(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. J Biol Chem 275: 4251-4257, 2000


  9. Yasukawa T, Suzuki T, Ishii N, Ueda T, Ohta S, Watanabe K: Defect in modification at the anticodon wobble nucleotide of mitochondrial tRNALys with the MERRF encephalomyopathy pathogenic mutation. FEBS Lett 467: 175-178, 2000


  10. Yasukawa T, Suzuki T, Ishii N, Ohta S, Watanabe K: Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. EMBO J 20: 4794-4802, 2001


  11. Hatanaka Y, Nakae D, Mutai M, Hashizume K, Kamihara Y, Kinoshita N, Tani Y, Danno G, Ohta S, Konishi Y, Asida H: Decreased expression of Bcl-x protein during hepatocarcinogenesis induced exogenously and endogenously in rats. Jpn J Cancer Res 92: 1270-1277, 2001


  12. Yasukawa T, Suzuki T, Ohta S, Watanabe K: Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion 2: 129-141, 2002


  13. Nomiyama T, Tanaka Y, Hattori N, Nishimaki K, Nagasaka K, Kawamori R, Ohta S: Accumulationa of somatic mutation in mitochondrial DNA extracted from peripheral blood cells in diabetic patients. Diabetologia. 45: 1577-1583, 2002


  14. Yamada Y, Ando F, Niino N, Ohta S, Shimokata H: Association of polymorphisms of the estrogen receptor α gene with bone mineral density of the femoral neck in elderly Japanese women. J Mol Med 80: 452-460, 2002


  15. Asoh S, Ohsawa I, Mori T, Katsura K, Hiraide T, Katayama Y, Kimura M, Ozaki D, Yamagata K, Ohta S: Protection against ischemic brain injury by protein therapeutics. Proc Natl Acad Sci USA. 99: 17107-17112, 2002


  16. Yasukawa T, Suzuki T, Ohta S, Watanabe K: Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion 2: 129-141, 2002


  17. Nakano K, Tanabe M, Nakagawa S, Ohta S, Suzuki S, Shimura M, Matuda S: Isolation and sequence analysis of the rat dihydrolipoamide succinyltransferase gene. DNA Seq. 13: 363-367, 2002


  18. Suzuki Y, Matsuura N, Suzuki S, Muramatsu T, Taniyama M, Ohta S, Higuchi S, Tsukahara M, Atsumi Y, Matsuoka K: Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Diabetes Res Clin Pract 60: 139-141, 2003


  19. Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S: Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem 84: 1110-1117, 2003


  20. Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S: Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J. 22: 2913-2923, 2003


  21. Ohsawa I, Nishimaki K, Yasuda C, Kamino K, Ohta S: Deficiency in a mitochondrial aldehyde dehydrogenase increases vulnerability to oxidative stress in PC12 cells. J Neurochem 84: 1110-1117, 2003


  22. Ohsawa I, Kamino K, Nagasaka K, Ando F, Niino N, Shimokata H, Ohta S: Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. J Hum Genet 48: 404-409, 2003


  23. Suzuki Y, Taniyama M, Muramatsu T, Ohta S, Atsumi Y, Matsuoka K: Influence of alcohol intake and aldehyde dehydrogenase 2 phenotype on peripheral neuropathy of diabetes. Diabetes Care 26: 249, 2003


  24. Suzuki Y, Taniyama M,Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K: Diabetic vasculopathy and alcohol tolerance trait in type 2 diabetes. Diabetes Care 26: 246-247, 2003


  25. Suzuki Y, Taniyama M, Muramatsu T, Ohta S, Murata C, Atsumi Y, Matsuoka K: Mitochondrial tRNA(Leu(UUR)) mutation at position 3243 and symptomatic polyneuropathy in type 2 diabetes. Diabetes Care 26: 1315-1316, 2003


  26. Suzuki Y, Kuriyama S, Atsumi Y, Murata C, Matsuoka K, Taniyama M, Muramatsu T, Ohta S: Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese. Diabetes Res Clin Pract 60: 143-145, 2003


  27. Nakano K, Ohsawa I, Yamagata K, Nakayama T, Sasaki K, Tarashima M, Saito K, Osawa M, Ohta S: Continuous culture of novel mitochondrial cells lacking nuclei. Mitochondrion 3: 21-27, 2003


  28. Usui K, Saijo Y, Narumi K, Koyama S, Maemondo M, Kikuchi T, Tazawa R, Hagiwara K, Ishibashi Y, Ohta S, Nukiwa T: N-terminal deletion augments the cell-death-inducing activity of BAX in adenoviral gene delivery to nonsmall cell lung cancers. Oncogene 22: 2655-2663, 2003


  29. Tahara K, Tsuchimoto D, Tominaga Y, Asoh S, Ohta S, Kitagawa M, Horie H, Kadoya T, Nakabeppu Y: DeltaFosB, but not FosB, induces delayed apoptosis independent of cell proliferation in the Rat1a embryo cell line. Cell Death Differ 10: 496-507, 2003


  30. Abe H, Nishimura T, Asoh S, Ohta S: Expression of Bcl-2 on leukocytes in prostatic fluid from patients with acute and chronic prostatitis. J Infect Chemother 9: 156-159, 2003


  31. Okura T, Koda M, Ando F, Niino N, Ohta S, Simokata H: Assocation of polymorphisms in the estrogen receptor α gene with bdy fat distribution. Int J Obes Relat Metab Disord 27: 1020-1027, 2003


얔@qj@i_ˑwEwEیwȁj
  1. Yasuda M, Maeda S, Kawamata T, Tamaoka A, Yamamoto Y, Kuroda S, Maeda K, Tanaka C: Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy. J Neurol Neurosurg Psychiat 68: 220-223, 2000


  2. Isagawa T, Mukai H, Oishi K, Taniguchi T, Hasegawa H, Kawamata T, Tanaka C, Ono Y: Dual effects of PKNalpha and protein kinase C on phosphorylation of tau protein by glycogen synthase kinase-3beta. Biochem Biophys Res Commun 273: 209-212, 2000


  3. Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47: 422-429, 2000


  4. Terashima A, Taniguchi T, Nakai M, Yasuda M, Kawamata T, Tanaka C: Rapamycin and FK506 induce long-term potentiation by pairing stimulation via an intracellular Ca(2+) signaling mechanism in rat hippocampal CA1 neurons. Neuropharmacology. 39: 1920-1928, 2000


  5. Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, Hashimoto T, Terashima A, Nakai M, Mori H, Ono Y, Tanaka C: Phosphorylation of tau is regulated by PKN. J Biol Chem 276: 10025-10031, 2001


  6. Nakai M, Tanimukai S, Yagi K, Saito N, Taniguchi T, Terashima A, Kawamata T, Yamamoto H, Fukunaga K, Miyamoto E, Tanaka C: Amyloid beta protein activates PKC-delta and induces trans­location of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia. Neurochem Int 38: 593-600, 2001


  7. Hasegawa H, Nakai M, Tanimukai S, Taniguchi T, Terashima A, Kawamata T, Fukunaga K, Miyamoto E, Misaki K, Mukai H, Tanaka C: Microglial signaling by amyloid beta protein through mitogen activated protein kinase mediating phosphorylation of MARCKS. NeuroReport 12: 2567-2571, 2001


  8. Tanimukai S, Hasegawa H, Nakai M, Yagi K, Hirai M, Saito N, Taniguchi T, Terashima A, Yasuda M, Kawamata T, Tanaka C: Nanomolar amyloid beta protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells. NeuroReport 13: 549-553, 2002


K@ǎO@iVwE]EȊw\[XZ^[j
  1. Shimomura Y, Sato N, Miyashita A, Hashimoto T, Ito M, Kuwano R: A rare case of hypohidrotic ectodermal dysplasia caused by compound heterozygous mutations in the EDAR gene. J Invest Dermatol 123: 649-655, 2004


  2. Hara K, Fukushima T, Suzuki T, Shimohata T, Oyake M, Ishiguro H, Hirota K, Miyashita A, Kuwano R, Kurisaki H, Yomono H, Goto J, Kanazawa I, Tsuji S: Japanese SCA families with an unusual phenotype linked to a locus overlapping with SCA15 locus. Neurology 62: 648-651, 2004


  3. Ishikawa A, Piao Y-S, Miyashita A, Kuwano R, Onodera O, Ohtake H, Suzuki M, Nishizawa M, Takahashi H: A mutant PSEN1 causes dementia with Lewy bodies and variant Alzheimerfs disease. Ann Neurol 57: 429-434, 2005


@_j@i×{a@EÌZ^[j
  1. Shimokata H, Yamada Y, Nakagawa M, Okubo R, Saido T, Funakoshi A, Miyasaka K, Ohta S, Tsujimoto G, Tanaka M, Ando F, Niino N: Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidemiol 10: S46-S55, 2000


  2. Yamada Y, Fujisawa M, Ando F, Niino N, Tanaka M, Shimokata H: Association of a polymorphism of the transforming growth factor-β1 gene with blood pressure in Japanese. J Hum Genet 47: 243-248, 2002


  3. Kohara K, Fujisawa M, Ando F, Tabara Y, Niino N, Miki T, Shimokata H: MTHFR gene polymorphism as risk factor for silent brain infarcts and white matter lesions in Japanese general population: NILS-LSA study. Stroke 34: 1130-1135, 2003


Cс@v@iRwEw@㎕wȁj
  1. Shoji M, Kanai M, Matsubara E, Ikeda M, Harigaya Y, Okamoto K, Hirai S: Taps to Alzheimerfs patients: a continuous Japanese study of cerebrospinal fluid biomarkers. Ann Neurol 48: 402, 2000


  2. Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Tomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S: Age-related amyloid β protein accumulation induces cellular death and macrophage activation in transgenic mice. J Pathol 191: 93-101, 2000


  3. Shoji M, Harigaya Y, Sasaki A, Ueda K, Ishiguro K, Matsubara E, Watanabe M, Ikeda M, Kanai M, Tomidokoro Y, Shizuka M, Amari M, Kosaka K, Nakazato Y, Okamoto K, Hirai S: Accumulation of NACP/alpha-synuclein in Lewy body disease and multiple system atrophy. J Neurol Neurosurg Psychiat 68: 605-608, 2000


  4. Shoji M, Kawarabayashi T, Matsubara E, Ikeda M, Ishiguro K, Harigaya Y, Okamoto K: The distribution of the amyloid β protein precursor in the Alzheimer's disease brain. Psychiat Clin Neurosci 54: 45-54, 2000


  5. Ikeda Y, Shizuka-Ikeda M, Watanabe M, Schmitt M, Okamoto K, Shoji M: Asymptomatic CTG expansion at the SCA8 locus is associated with cerebellar atrophy on MRI. J Neurol Sci 182: 76-79, 2000


  6. Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG: Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimerfs disease brain. Biochem Biophys Res Commun 276: 422-427, 2000


  7. Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Okamoto K, Shoji M: Impaired neurotransmitter systems by Aβ amyloidosis in APPsw transgenic mice overexpressing amyloid beta protein precursor. Neurosci Lett 292: 155-158, 2000


  8. Wegiel J, Wisniewski HM, Muzylak M, Tarnawski M, Badmajew E, Nowakowski J, Wang KC, Shoji M, Mondadori C, Giovanni A: Fibrillar amyloid-beta production, accumulation, and recycling in transgenic mice pancreatic acinar cells and macrophages. Amyloid 7: 95-104, 2000


  9. Ikeda Y, Shizuka M, Watanabe M, Okamoto K, Shoji M: Molecular and clinical analyses of spinocerebellar ataxia type 8 in Japan. Neurology 54: 950-955, 2000


  10. Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S: The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently. Neurobiol Aging 22: 209-215, 2001


  11. Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid(1-42) in cerebraospinal fluid as a diagnositic marker for Alzheimerfs disease and related disorders: multi center study in Japan. Psychogeriatrics 1: 56-63, 2001


  12. Dobrogowska DH, Vorbrodt AW, Wegiel J, Wang KC, Shoji M, Mondadori C, Polatis G, Giovanni A, Wisniewski HM: Cytochemical study of the involvement of cell organelles in formation and accumulation of fibrillar amyloid in the pancreas of NORβ transgenic mice. Histol Histopathol 16: 1047-1056, 2001


  13. Manabe Y, Warita H, Murakami T, Shiote M, Hayashi T, Nagano I, Shoji M, Abe K: Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene. Brain Res 915: 104-107, 2001


  14. Manabe Y, Wang JM, Murakami T, Warita H, Hayashi T, Shoji M, Abe K: Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite. J Neurosci Res 65: 371-377, 2001


  15. Paganelli AR, Ocana OH, Prat MI, Franco PG, Lopez SL, Morelli L, Adamo AM, Riccomagno MM, Matsubara E, Shoji M, Affranchino JL, Castano EM, Carrasco AE: The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mech Dev 107: 119-131, 2001


  16. Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M: Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol 194: 500-506, 2001


  17. Murakami T, Nagano I, Hayashi T, Manabe Y, Shoji M, Setoguchi Y, Abe K: Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene. Neurosci Lett 308: 149-152, 2001


  18. Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001


  19. Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park JM, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M: Aβ amyloidosis induces the initial stage of tau accumulation in APP (sw) mice. Neurosci Lett 299: 169-172, 2001


  20. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimerfs disease. J Neurosci 21: 372-381, 2001


  21. Manabe Y, Murakami T, Iwatsuki K, Narai H, Warita H, Hayashi T, Shoji M, Imai Y, Abe K: Nocturnal blood pressure dip in CADASIL. J Neurol Sci 193: 13-16, 2001


  22. Murakami T, Iwatsuki K, HayashiT, Sato K, Matsubara E, Nagano I, Manabe Y, Shoji M, Abe K: Two Japanese CADASIL families with a R141C mutation in the Notch3 gene. Int Med 40: 1144-1148, 2001


  23. Takenoshita H, Shizuka-Ikeda M, Mitoma H, Song S, Harigaya Y, Igeta Y, Yaguchi M, Ishida K, Shoji M, Tanaka M, Mizusawa H, Okamoto K: Presynaptic inhibition of cerebellar GABAergic transmission by glutamate decarboxylase autoantibodies in progressive cerebellar ataxia. J Neurol Neurosurg Psychiat 70: 386-389, 2001


  24. Shoji M, Kanai M: Cerebrospinal fluid Aβ40 and Aβ42: natural course and clinical usefulness. J Alz Dis 3: 313-321, 2001


  25. Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe W, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ich K, Yoshida H, Toji, H Nakamura S, Hirai H: Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002


  26. Shoji M, Fukushima K, Wakayama M, Shizuka-Ikeda M, Ikeda Y, Kawakami A, Sakazume Y, Ikeda M, Harigaya Y, Matsubara E, Kawarabayashi T, Murakami T, Nagano I, Manabe Y, Abe K: Intellectual faculities in patients with Alzheimerfs disease regress to the level of a 4-5-year old child. Geriat Gerontol Int 2: 143-147, 2002


  27. Matsubara E, Shoji M, Murakami T, Abe K, Frangione B, Ghiso J: Platelet microparticles as carriers of soluble Alzheimerfs amyloid β (Aβ). Ann NY Acad Sci 977: 340-348, 2002


  28. Abe K, Murakami T, Matsubara E, Manabe Y, Nagano I, Shoji M: Clinical Features of CADASIL. Ann NY Acad Sci 977: 266-272, 2002


  29. Kamada H, Sato K, Iwai M, Zhang WR, Nagano I, Manabe Y, Shoji M, Abe K: Spatiotemporal changes of free cholesterol and neutral lipids after transient middle cerebral artery occlusion in rats. Ann NY Acad Sci 977: 115-22, 2002


  30. Jin G, Omori N, Li F, Sato K, Nagano I, Manabe Y, Shoji M, Abe K: Activation of cell-survival signal Akt by GDNF in normal rat brain. Brain Res 958: 429-33, 2002


  31. Li F, Omori N, Sato K, Jin G, Nagano I, Manabe Y, Shoji M, Abe K: Coordinate expression of survival p-ERK and proapoptotic cytochrome c signals in rat brain neurons after transient MCAO. Brain Res 958: 83-88, 2002


  32. Omori N, Jin G, Li F, Zhang WR, Wang SJ, Hamakawa Y, Nagano I, Manabe Y, Shoji M, Abe K: Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion. Brain Res 954: 317-322, 2002


  33. Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neuritis. Virchows Arch 441: 358-367, 2002


  34. Wang SJ, Omori N, Li F, Zhang WR, Jin G, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Enhanced expression of phospho-Akt by electro-acupuncture in normal rat brain. Neurol Res 24: 719-724, 2002


  35. Sato K, Murakami T, Hamakawa Y, Kamada H, Nagano I, Shoji M, Takata H, Nobukuni K, Ihara Y, Namba R, Hayabara T, Hirose S, Abe K: Selective colocalization of transglutaminase-like activity in ubiquitinated intranuclear inclusions of hereditary dentatorubral-pallidoluysian atrophy. Brain Res 952: 327-330, 2002


  36. Wang SJ, Omori N, Li F, Jin G, Zhang WR, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Potentiation of Akt and suppression of caspase-9 activations by electroacupuncture after transient middle cerebral artery occlusion in rats. Neurosci Lett 331: 115-8, 2002


  37. Sato K, Iwai M, Nagano I, Shoji M, Abe K: Temporal and spatial changes of BrdU immunoreactivity in amygdala kindling development. Neurol Res 24: 593-596, 2002


  38. Warita H, Manabe Y, Murakami T, Shiote M, Shiro Y, Hayashi T, Nagano I, Shoji M, Abe K: Tardive decrease of astrocytic glutamate transporter protein in transgenic mice with ALS-linked mutant SOD1. Neurol Res 24: 577-581, 2002


  39. Sato K, Iwai M, Nagano I, Shoji M, Abe K: Changes of localization of highly polysialylated neural cell adhesion molecule (PSA-NCAM) in rat hippocampus with exposure to repeated kindled seizures. Brain Res 946: 323-327, 2002


  40. Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Setoguchi Y, Abe K: Adenovirus-mediated gene transfer of glial cell line-derived neurotrophic factor prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Apoptosis 7: 329-334, 2002


  41. Manabe Y, Warita H, Murakami T, Shiote M, Hayashi T, Omori N, Nagano I, Shoji M, Abe K: Early decrease of the immunophilin FKBP 52 in the spinal cord of a transgenic model for amyotrophic lateral sclerosis. Brain Res 935: 124-128, 2002


  42. Prat MI, Adamo AM, Gonzalez SA, Affranchino JL, Ikeda M, Matsubara E, Shoji M, Smith MA, Castano EM, Morelli L: Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein : relevance for neurodegeneration. Neurosci Lett 326: 9-12, 2002


  43. Sato K, Iwai M, Nagano I, Shoji M, Abe K: Expression of highly polysialylated neural cell adhesion molecule in rat subventricular zone with exposure to repeated kindled seizures. Neurosci Lett 323: 244-246, 2002


  44. Iwai M, Sato K, Omori N, Nagano I, Manabe Y, Shoji M, Abe K: Three steps of neural stem cells development in gerbil dentate gyrus after transient ischemia. J Cereb Blood Flow Metab 22: 411-419, 2002


  45. Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castano EM, St George-Hyslop P, Shoji M: Generation of amyloid beta protein from a presenilin-1 and βAPP complex. Biochem Biophys Res Commun 292: 571-578, 2002


  46. Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE: Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol Dis 9: 11-23, 2002


  47. Ohta Y, Hayashi T, Sasaki C, Shiote M, Manabe Y, Shoji M, Abe K: Cauda equina syndrome caused by idiopathic sacral epidural lipomatosis. Intern Med 41: 593-594, 2002


  48. Ohta Y, Manabe Y, Sasaki C, Shiote M, Hayashi T, Shoji M, Abe K: A case of paroxysmal kinesigenic dyskinesia with spastic paraparesis. Neurol Res 24: 684-686, 2002


  49. Manabe Y, Narai H, Warita H, Hayashi T, Shiro Y, Sakai K, Kashihara K, Shoji M, Abe K: Benign adult familial myoclonic epilepsy (BAFME) with night blindness. Seizure 11: 266-268, 2002


  50. Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem 278: 51901-51910, 2003


  51. Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimerfs disease. J Neurochem 85: 1101-1108, 2003


  52. Kamada H, Sato K, Zhang WR, Omori N, Nagano I, Shoji M, Abe K: Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain. J Neurosci Res 73: 545-556, 2003


  53. Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K: Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein. J Neurol Sci 215: 57-62, 2003


  54. Wang SJ, Omori N, Li F, Jin G, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats. Neurol Res 25: 516-521, 2003


  55. Murakami T, Ilieva H, Shiote M, Nagata T, Nagano I, Shoji M, Abe K: Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene. Brain Res 989: 231-237, 2003


  56. Manabe Y, Wang JM, Shiote M, Murakami T, Nagano I, Shoji M, Abe K: Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats. Neurol Res 25: 312-316, 2003


  57. Omori N, Maruyama K, Jin G, Li F, Wang SJ, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferring. Neurol Res 25: 275-259, 2003


  58. Jin G, Omori N, Li F, Nagano I, Manabe Y, Shoji M, Abe K: Protection against ischemic brain damage by GDNF affecting cell survival and death signals. Neurol Res 25: 249-253, 2003   Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Abe K: Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 25: 195-200, 2003


  59. Iwai M, Sato K, Kamada H, Omori N, Nagano I, Shoji M, Abe K: Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils. J Cereb Blood Flow Metab 23: 331-341, 2003


  60. Sato K, Iwai M, Nagano I, Shoji M, Abe K: Temporal and spatial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development. Neurol Res 25: 79-82, 2003


  61. Li F, Omori N, Jin G, Wang SJ, Sato K, Nagano I, Shoji M, Abe K: Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO. Brain Res 962: 21-26, 2003


  62. Ohta K, Iwai M, Sato K, Omori N, Nagano I, Shoji M, Abe K: Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. Neurosci Lett 335: 159-162, 2003


  63. Kamada H, Sato K, Iwai M, Zhang WR, Nagano I, Manabe Y, Shoji M, Abe K: Temporal and spatial changes of free cholesterol and neutral lipids in rat brain after transient middle cerebral artery occlusion. Neurosci Res 45: 91-100, 2003


  64. Moreira MC, Klur S, Watanabe M, Nemeth AH, Ber IL, Moniz JC, Tranchant C, Aubourg P, Tazir M, Schols L, Pandolfo M, Schulz JB, Pouget J, Calvas P, Shizuka-Ikeda M, Shoji M, Tanaka M, Izatt L, Shaw CE, M'Zahem A, Dunne E, Bomont P, Benhassine T, Bouslam N, Stevanin G, Brice A, Guimaraes J, Mendonca P, Barbot C, Coutinho P, Sequeiros J, Durr A, Warter JM, Koenig M: Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet 69: 225-227, 2004


  65. Ikeda Y, Dalton JC, Moseley ML, Gardner KL, Bird TD, Ashizawa T, Seltzer WK, Pandolfo M, Milunsky A, Potter NT, Shoji M, Vincent JB, Day JW, Ranum LP: Spinocerebellar ataxia type 8: molecular genetic comparisons and haplotype analysis of 37 families with ataxia. Am J Hum Genet 75: 3-16, 2004


  66. Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric Aβ rapidly accumulates in lipid rafts followed by ApoE and phosphorylated tau as memory is impaired in the Tg2576 mouse model of Alzheimerfs Disease. J Neurosci 24: 3801-3809, 2004


  67. Murakami T, Shoji-M, Imai Y, Inoue H, KawarabayashiT, Matsubara E, Harigaya Y, SasakiA, Takahashi R, AbeK: Pael-R is accumulated in Lewy bodies of Parkinsonfs disease. Ann Neurol 55: 439-442, 2004


  68. Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25: 483-490, 2004


  69. Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aβ homeostasis in AD and DS : impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging 25: 833-841, 2004


  70. Li F, Omori N, Hayashi T, Jin G, Sato K, Nagano I, Shoji M, Abe K: Protection against ischemic brain damage in rats by immunophilin ligand GPI-1046. J Neurosci Res 76: 383-389, 2004


  71. Hamakawa Y, Omori N, Ouchida M, Nagase M, Sato K, Nagano I, Shoji M, Fujita T, Abe K: Severity dependent up-regulations of LOX-1 and MCP-1 in early sclerotic changes of common carotid arteries in spontaneously hypertensive rats. Neurol Res 26: 767-773, 2004


  72. Morimoto N, Nagano I, Deguchi K, Murakami T, Fushimi S, Shoji M, Abe K: A case of Leberfs hereditary optic neuropathy (LHON) with chorea and dementia resembling Huntingtonfs disease. Neurology 63: 2451-2452, 2004


  73. Kurata T, Matsubara E, Yokoyama M, Nagano I, Shoji M, Abe K: Improvement of SSPE by intrathecal infusion of α-IFN. Neurology 63: 398-399, 2004


  74. Yamashita T, Matsubara E, Nagano I, Shoji M, Abe K: Bilateral extraocular muscle atrophy in myotonic dystrophy type 1. Neurology 63: 759-760, 2004


  75. Ohta Y, Nagano I, Niiya D, Fujioka H, Kishimoto T, Shoji M, Abe K: Nonparaneoplastic limbic encephalitis with relapsing polychondritis. J Neurol Sci 220: 85-88, 2004


  76. Ikeda M, Shoji M, Kawarai T, Kawarabayashi T, Matsubara E, Murakami T, Sasaki A, Tomidokoro Y, Ikarashi Y, Kuribara H, Ishiguro K, Hasegawa M, Yen SH, Davies P, Chishti M A, Harigaya Y, Okamoto K, Abe K, Carlson GA, St.George-Hyslop P, Westaway D: Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic mice. Am J Pathol 166: 521-531, 2005


  77. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, Miyoshi K, Yamada T, Kikuchi H, Taniwaki T, Murai H, Ikezoe K, Furuya H, Kawarabayashi T, Shoji M, Checler F, Iwaki T, Makifuchi T, Takeda K, Kira J, Tabira T: Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimerfs disease. FASEB J 19: 255-257, 2005


  78. Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St. George-Hyslop P, Nishimura M: Random mutagenosis of presenilin 1 identifies novel mutation exclusively generating long amyloid β peptides. J Biol Chem 280: 19070-19077, 2005


  79. Nagotani S, Hayashi T, Deguchi K, Nagano I, Shoji M, Abe K: Reduction of cerebral infarction in SHR-SP by statins associated with amelioration of oxidative stress. Stroke 6: 670-672, 2005.


  80. Jin G, Hayashi T, Kawagoe J, Takizawa T, Nagata T, Nagano I, Shoji M, Abe K: Deficiency of PAR-2 gene increases acute focal ischemic brain injury. J Cereb Blood Flow Metab 25: 302-313, 2005


  81. Shiote M, Nagano I, Ilieva H, Murakami T, Narai H, Ohta Y, Nagata T, Shoji M, Abe K: Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1, by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 132: 175-182, 2005


  82. Kamada H, Hayashi T, Sato K, Iwai M, Nagano I, Shoji M, Abe K: Up-regulation of low-density lipoprotein receptor expression in the ischemic core and the peri-ischemic area after transient MCA occlusion in rats. Mol Brain Res 134: 181-188, 2005


  83. Deguchi K, Takaishi M, Hayashi T, Oohira A, Nagotani S, Li F, Jin G, Nagano I, Shoji M, Miyazaki M, Abe K, Huh NH: Expression of neurocan after transient middle cerebral artery occlusion in adult rat brain. Brain Res 1037: 194-199, 2005


  84. Hayashi T, Hamakawa K, Nagotani S, Jin G, Li F, Deguchi K, Sehara Y, Zhang H, Nagano I, Shoji M, Abe K: HMG CoA reductase inhibitors reduce ischemic brain injury of Wistar rats through decreasing oxidative stress on neurons. Brain Res 1037: 52-58, 2005


  85. Hayashi T, Iwai M, Ikeda T, Jin G, Deguchi K, Nagotani S, Zhang H, Sehara Y, Nagano I, Shoji M, Ikenoue T, Abe K: Neural precursor cells division and migration in neonatal rat brain after ischemic/hypoxic injury. Brain Res 1038: 41-49, 2005


@iY@i鋞wEwj
  1. Kunugi H, Akahane A, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease. J Neural Transm107: 1081-1084, 2000


  2. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association. Am J Med Genet 96: 307-309, 2000


  3. Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimerfs disease. Mol Psychiat 6: 83-86, 2001


  4. Kunugi H, Kato T, Fukuda R, Tatsumi M, Sakai T, Nanko S: Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders. J Neural Transm 109: 213-218, 2002


  5. Hattori M, Kunugi H, Akahane A, Tanaka H, Ishida S, Hirose T, Morita R, Yamakawa K, Nanko S: Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. Am J Med Genet 114: 304-309, 2002


  6. Hata T, Kunugi H, Nanko S, Fukuda R, Kaminaga T: Possible effect of the APOE varepsilon 4 allele on the hippocampal volume and asymmetry in schizophrenia. Am J Med Genet 114: 641-642, 2002


  7. Akahane A, Kunugi H, Tanaka H, Nanko S: Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia. Schizophr Res 58: 37-41, 2002


  8. Kato T, Iwamoto K, Washizuka S, Mori K, Tajima O, Akiyama T, Nanko S, Kunugi H, Kato N: No association of mutations and mRNA expression of WFS1/wolframin with bipolar disorder in humans. Neurosci Lett 338: 21-24, 2003


  9. Nanko S, Kunugi H, Hirasawa H, Kato N, Nabika T, Kobayashi S: Brain-derived neurotrophic factor gene and schizophrenia: polymorphism screening and association analysis. Schizophr Res 62: 281-283, 2003


  10. Kakiuchi C, Iwamoto K, Ishiwata M, Bundo M, Kasahara T, Kusumi I, Tsujita T, Okazaki Y, Nanko S, Kunugi H, Sasaki T, Kato T: Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet 35: 171-175, 2003


  11. Washizuka S, Kakiuchi C, Mori K, Kunugi H, Tajima O, Akiyama T, Nanko S, Kato T: Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am J Med Genet 120: 72-78, 2003


@i@ia@@\EvlAR[ǃZ^[j
  1. Yamaya N, Nakayama K, Ebihara S, Hirai H, Higuchi S, Sasaki H: Relationship between microsatellite polymorphism in the haem oxynase-1 gene promoter and longevity of the normal Japanese population. J Med Genet 40: 146-148, 2003


  2. Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K: Diabetic vasculopathy and alcohol torelance trait in type 2 diabetes. Diabetes Care 26: 246-247, 2003


  3. Nakamura Y, Ishikawa A, Sekiguchi S, Kuroda M, Imazeki H, Higuchi S: Spirits and gastrectomy increase risk for chrnonic pancreatitis in Japanese male alcoholics. Pancreas 26: 27-31, 2003


  4. Suzuki Y, Matsuura N, Suzuki S, Muramatsu T, Taniyama T, Ohta S, Higuchi S, Atusmi Y, Matsuoka K: Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Diabetes Res Clin Pract 60: 139-141, 2003


  5. Mochizuki H, Masaki T, Kamakura K, Matsushita S, Kusunoki S, Higuchi S: Acute axonal polyneuropathy associated with alcoholism. Eur Neurol 50: 183-184, 2003


  6. Mochizuki H, Masaki T, Miyakawa T, Nakane J, Yokoyama A, Nakamura Y, Okuyama K, Kamakura K, Motoyoshi K, Matsushita S, Higuchi S: Benign type of central potine myelinolysis in alcoholism: clinincal neuropathological and electrophysiological findings. J Neurol 250: 1077-1083, 2003


  7. Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinsonfs disease. Ann Neurol 54: 276-277, 2003


  8. Yokoyama A, Yokoyama T, Muramatsu T, Omori T, Matsushita S, Higuchi S, Maruyama K, Ishii H: Macrocytosis, a new predictor of esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 24: 1773-1778. 2003


  9. Miyatake R, Furukawa A, Matsushita S, Higuchi S, Suwaki H: Functional polymorphisms in the s1 receptor gene associated with alcoholism. Biol Psychiat 55: 85-90, 2004


  10. Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Maruyama K, Niino N, Ando F, Shimokata H, Ohta S, Funakoshi A: Association of chelocystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol Alcohol 39: 25-28, 2004


  11. Nakamura Y, Yokoyama H, Higuchi S, Hara S, Kato S, Ishii H: Acetaldehyde accumulation suppresses Kupffer cell release of TNF-α and modifies acute hepatitis in rats. J Gastroenterol 39: 140-147, 2004


  12. Maruyama K, Higuchi S: The Japanese society of alcohol-related problems. Addiction 99: 419-424, 2004


  13. Miyasaka K, Yoshida Y, Matsushita S,Higuchi S,Shirakawa O, Shimokata H, Funakoshi A: Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese. Am J Med Genet 127B: 78-80, 2004


  14. Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S, Koike K, Okamura N, Matsushita S, Suzuki K, Murayama M, Higuchi S, Iyo M: Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders. Am J Med Genet 127B: 125-127, 2004


  15. Adachi J, Matsushita S, Yoshioka N, Funae R, Fujita T, Higuchi S, Ueno Y: Plasma phosphatidylcholine hydroperoxidase as a new marker of oxidative stress in alcoholic patients. J Lipid Res 45: 967-971, 2004


  16. Nakamura Y, Kobayshi Y, Ishikawa A, Maruyama K, Higuchi S: Severe chronic pancreatitis and severe cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholics. J Gastroenterol 39: 879-887, 2004


  17. Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, Shirakawa O, Higuchi S: Serotonin transporter regulatory region polymorphism is associated with gcoreh anorexia nervosa. Am J Med Genet 128B: 114-117, 2004


  18. Masaki T, Mochizuki H, Matsushita S, Yokoyama A, Kamakura K, Higuchi S: Association of aldehyde dehydrogenase-2 polymorphisms with alcoholic polyneuropathy in humans. Neurosci Lett 363: 288-290, 2004


  19. Mochizuki H, Masaki T, Yokoyama A, Matsushita S, Kamakura K, Motoyoshi K, Higuchi S: Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2. Neurosci Res 50: 233-236, 2004


  20. Nakamura Y, Ohmori T, Ishikawa A, Kobayashi Y, Imazeki H, Higuchi S, Maruyama K: Homozygous (TG)11 allele in intron 8 of th cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against biocarbonate decrease in pure pancreatic juice among Japanese male alcoholics. Intern Med 43: 1131-1137, 2004


  21. Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S: Association study of brain-derived neurotrophic factor (BDNF) gene polymorphism and alcoholism. Alcohol Clin Exp Res 28: 1609-1612, 2004


  22. Mochizuki H, Masaki T, Matsushita S, Ugawa Y, Kamakura K, Arai H, Motoyoshi K, Higuchi S: Cognitive impairment and diffuse white matter atrophy in alcoholics. Clin Neurophysiol 116: 223-228, 2005


  23. Matsushita S, Arai H, Matsui T, Yuzuriha T, Urakami K, Masaki T, Higuchi S: Brain-derived neurotrophic factor gene polymorphisms and Alzheimerfs disease. J Neural Transm 112: 703-711, 2005


  24. Miyasaka K, Ohta M, Takano S, Hayashi H, Higuchi S, Maruyama K, Tando Y, Nakamura T, Takata Y, Funakoshi A: Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitis. Pancreas 30: e87-91, 2005


Oc@@i_ˑwEw@wnȁj
  1. Yamamoto Y, Sengo M, Yasuda M, Maeda K: No association between presenilin 1 intron gene or butyrylcholinesterase K variant and Alzheimerfs disease in Japanese populations. Psychogeriatrics. 1: 108-118, 2001


  2. Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, Maeda K: No evidence of an association between 5HT1B receptor gene polymorphisim and suicide victims in a Japanese population. Am J Med Genet 105: 343-345, 2001


  3. Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K: Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiat Res 35: 173-176, 2001


  4. Lin X.H, Hashimoto T, N Kitamura, Murakami N, Shirakawa O, Maeda K: Decreased signal transmission via calcineurin and increased phosphothreonine-DARPP-32 in the striatum of rats behaviorally sensitized to methamphetamine. Synapse 44: 181-187, 2002


  5. Ono H, Shirakawa O, Nishiguti N, Nishimura A, Nushida H, Ueno Y, Maeda K: No evidence of an association between a functional monoamine oxidase A gene polymorphism and completed suicides. Am J Med Genet 114: 340-342, 2002


  6. Nishiguchi, N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, Maeda K: Lack of an association between 5HT1A receptor genesstructural polymorphisms and suicide victims. Am J Med Genet 114: 423-425 2002


  7. Ono H, Shirakawa O, Kitamura N. Hashimoto T, Nishiguti N, Nishimura A, Nushida H, Ueno Y, Maeda K: Tryptophan hydroxylase immunoreactivities are altered by the genetic variation in postmortem brain samples in both suicide victims and controls. Mol Psychiat 7: 1127-1132, 2002


  8. Yanagihara C, Yasuda M, Maeda K, Miyoshi K, Nishimura Y: Rapidly progressive dementia syndrome associated with a novel four extra repeat mutation in the prion protein gene. J Neurol Neurosurg Psychiat 72: 788-791, 2002


  9. Toyooka K, Iritani S, Makifuchi T, Shirakawa O, Kitamura N, Maeda K, Nakamura R, Niizato K, Watanabe M, Kakita A, Takahashi H, Someya T, Nawa H: Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J Neurochem 83: 797-806, 2002


  10. Aoyama S, Shirakawa O, Ono H, Hashimoto T, Kajimoto Y, Maeda K: A novel polymorphism in the coding region of the DAP-1 gene (hDLG and PSD-95associated protein-1 gene): analysis of association with schizophrenia. Psychiat Clin Neurosci 57: 545-547, 2003


  11. Kajimoto Y, Shirakawa O, Lin X-H, Hashimoto T, Kitamura, N, Murakami N, Takumi T, Maeda K: Synapse-associated protein 90/postsynaptic density-95-associated protein (SAPAP) is expressed differentially in the nucleus accumbens of phencyclidine-treated rats and is increased in the nucleus accumbens of patients with schizophrenia. Neuropsychopharmacology. 28: 1831-1839, 2003



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