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岡野栄之（大阪大学・大学院医学系研究科）
1. Kaneko Y, Sakakibara S, Imai T, Suzuki A, Nakamura Y, Sawamoto K, Ogawa
Y, Toyama Y, Miyata T, Okano H: Musashi1: an evolutionally conserved marker
for CNS progenitor cells including neural stem cells. Dev Neurosci
22: 139-153, 2000
2. Tabuchi K, Sawamoto K, Suzuki E, Sone M, Hama C, Yoshihara Y, Nose
A, Okano H: GAL4/ UAS-WGA system as a powerful tool for tracing Drosophila
multi-synaptic neural pathways. J Neurosci Res 59: 94-99, 2000
3. Nakamura Y, Sakakibara S, Miyata T, Ogawa M, Shimazaki T, Weiss S,
Kageyama R, Okano H: The bHLH gene Hes1 as a repressor of neuronal commitment
of the CNS stem cells. J Neurosci 20: 283-293, 2000
4. Roy NS, Benraiss A, Wang S, Fraser RAR, Goodman R, Couldwell WT, Nedergaard
M, Kawaguchi A, Okano H, Goldman SA: Promoter-targeted selection and isolation
of neural progenitor cells from the adult human ventricular zone. J
Neurosci Res 59: 321-331, 2000
5. Roy NS, Wang S, Jiang L, Kang J, Restelli C, Fraser RAR, Couldwell
WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA: In vitro neurogenesis
by neural progenitor cells isolated from the adult human hippocampus.
Nat Med 6: 271-278, 2000
6. Igaki T, Kanuka H, Inohara N, Sawamoto K, Nunez G, Okano H, Miura M:
Drob-1, a Drosophila member of the CED-9/Bcl-2 family that promotes cell
death. Proc Natl Acad Sci USA 97: 662-667, 2000
7. Taguchi A, Sawamoto K, Okano H: Mutations modulating Argos-regulated
signaling pathway during Drosophila eye development. Genetics 154:
1639-1648, 2000
8. Hisahara S, Araki T, Sugiyama F, Yagami K, Suzuki M, Abe K, Yamamura
K, Miyazaki J, Momoi T, Bernard CA, Okano H, Miura M: Targetted expression
of baculovirus p35 inhibitor in oligodendrocytes protects mice against
autoimmune-mediated demyelination. EMBO J 19: 341-348, 2000
9. Ohtani T, Ishihara K, Atsumi T, Nishida K, Keneko Y, Miyata T, Itoh
S, Narimatsu M, Maeda H, Fukada T, Itoh M, Okano H, Hibi T, Hirano T:
Dissection of signaling cascade through gp130 in vivo: Reciprocal roles
for STAT3-and SHP2-mediated signals in cytokine and immunoglobulin production.
Immunity 12: 95-105, 2000
10. Jin M, Ito M, Sawamoto K, Okano H: The interaction between Drosophila
secreted protein Argos and EGF receptor inhibits dimerization of the receptor
and binding of secreted Spitz to the receptor. Mol Cell Biol 20:
2098-2107, 2000
11. Araki T, Shibata M, Takano R, Hisahara S, Sugiyama F, Yagami K, Imamura
S, Fukuuchi Y, Saruta T, Okano H, Miura M: Conditional expression of anti-apoptotic
protein p35 by Cre-mediated DNA recombination in cells from p35 transgenic
mice. Cell Death Differ 7: 485-492, 2000
12. Kawashima T, Murakami AR, Ogasawara M, Tanaka K J, Isoda R, Sasakura
Y, Nishikata T, Okano H, Makabe KW: Expression patterns of musashi homologus
of the ascidians, Halocynthia roretzi and Ciona intestinalis. Dev Gene
Evol 210: 162-165, 2000
13. Takano R, Hisahara S, Mamikawa K, Kiyama H, Okano H, Miura M: Nerve
Growth Factor protects TNF-a induced oligodendrocytes injury through PI
3-kinase/Akt-mediated signaling mechanisms. J Biol Chem 275: 16360-16365,
2000
14. Imai H, Nakamoto H, Ishida Y, Inoue T, Kanno Y, Okada H, Suzuki S,
Okano H, Suzuki H: Glucocoticoid restores the deterioration of water transport
in the peritoneum through increment in aquaporin. Adv Perit Dial
16: 297-302, 2000
15. Sawa H, Kouike H, Okano H: Components of the SWI/SNF complex are required
for asymmetric cell division in C. elegans. Mol Cell 6: 617-624,
2000
16. Shibata M, Hisahara S, Hara H, Yamawaki T, Fukuuchi Y, Yuan J, Okano
H, Miura M: Caspase determines the vulnerability of oligodendrocytes in
cerebral white matter in ischemia. J Clin Invest 106: 643-653,
2000
17. Nguyen TQ, Sawa H, Okano H, White JG: The C. elegans septin genes,
unc-59 and unc-61, are required for normal postembryonic cytokineses and
morphogenesis but have no essential function in embryogenesis. J Cell
Sci 113: 3825-3837, 2000
18. Yoda A, Sawa H, Okano H: MSI-1, a neural RNA-binding protein, is involved
in the male mating behavior in Caenorhabditis elegans. Genes Cells
5: 885-895, 2000
19. Kawaguchi A, Miyata T, Sawamoto K, Takashita N, Murayama A, Akamatsu
W, Ogawa M, Okabe M, Tano Y, Goldman SA, Okano H: Nestin-EGFP transgenic
mice: visualization of self-renewal and multipotency of the CNS stem cells.
Mol Cell Neurosci 17: 259-273, 2001
20. Oishi I, Iwai K, Kagohashi Y, Fujimoto H, Kariya K, Kataoka T, Sawa
H, Okano, H Otani, H, Yamamura H, Minami Y: Critical role of a C. elegans
CDS1-related kinase in meiotic recombination. Mol Cell Biol
21: 1329-1335, 2001
21. Hisahara S, Yuan J, Momoi T, Okano H, Miura M: Caspase-11 mediates
oligodendrocyte cell death and pathogenesis of auto-immune mediated demyelination.
J Exp Med 193: 111-122, 2001
22. Kishi N, Tang J, Maeda Y, Ito M, Suzuki S, Kinoshita T, Kadesch T,
Hui C-C, Atravanis-Tsakonas S, Okano H, Matsuno K: Murine homologs of
deltex define a novel gene family which is involved in vertebrate Notch
signaling and neurogenesis. Int J Dev Neurosci in press
23. Toda M, Iizuka Y, Yu W-J, Ikeda E, Yoshida K, Imai T, Kawase T, Kawakami
Y, Okano H, Uyemura K: Expression of the neural RNA-binding protein Musashi1
in human gliomas. Glia in press
24. Mori H, Sakakibara S, Imai T, Nakamura Y, Iijima T, Suzuki A, Yuasa
Y, Takeda M, Okano H: Expression of mouse igf2 mRNA-binding protein 3
and its implication in the developing central nervous system. J Neurosci
Res in press
25. Murata T, Nagaso H, Watanabe S, Okano H, Yokoyama K: Poly(A) polymerase
modulates Notch signaling activity in the wing disc of Drosophila. Dev
Biol in press
26. Okabe M, Imai T, Kurusu M, Hiromi Y, Okano H: A neural potential determined
by post-transcriptional regulation in Drosophila. Nature in press
中福雅人（東京大学・大学院医学系研究科）
1. Takebayashi H, Yoshida S, Kominami R, Nakafuku M, Nabeshima Y: Olig
family of basic helix-loop-helix factors includes Olig1 and Olig2 implicated
in oligodendrogenesis and the third paralogous gene, Olig3. Mech Dev
99: 143-148, 2000
石川良樹（群馬大学・医学部）
1. Saishin Y, Ishikawa R, Ugawa S, Guo W, Ueda T, Morimura H, Kohama K,
Shimizu H, Tano Y, Shimada S: Retinal fascin: Functional nature, subcellular
distribution, and chromosomal localization. Invest Ophthalmol Vis Sci
41: 2087-2095, 2000
小椋利彦（奈良先端科学技術大学院大学）
1. Koshiba-Takeuchi K, Takeuchi JK, Matsumoto K, Momose T, Uno K, Hoepker
V, Ogura K, Takahashi N, Nakamura H, Yasuda K, Ogura T: Tbx5 and the retinotectum
projection.Science 281: 134-137, 2000
2. Grun F, Hirose Y, Kawauchi S, Ogura T, Umesono K: ALDH6, a cytosolic
retinaldehyde dehydrogenase prominently expressed in sensory neuroepithelia
during development.J Biol Chem 275: 41210-41218, 2000
3. Ogura K, Matsumoto K, Kuroiwa A, Isobe T, Otoguro T, Jurecic V, Baldini
A, Matsuda Y, Ogura T:Cloning and chromosomal mapping of human and chicken
iroquois (Irx) genes. Cytogenet Cell Genet in press
貝淵弘三（名古屋大学・大学院医学研究科）
1. Arimura N, Inagaki N, Chihara K, Menager C, Nakamura N, Amano M, Iwamatsu
A, Goshima Y, Kaibuchi K: Phosphorylation of collapsin response mediator
protein-2 by Rho-kinase. Evidence for two separate signaling pathways
for growth cone collapse. J Biol Chem 275: 23973-23980, 2000
2. Szaszi K, Kurashima K, Kapus A, Paulsen A, Kaibuchi K, Grinstein S,
Orlowski J: RhoA and Rho-kinase regulate the epithelial Na+/H+ exchanger NHE3. Role of myosin light chain phosphorylation.
J Biol Chem 275: 28599-28606, 2000
3. Eto Y, Shimokawa H, Hiroki J, Morishige K, Kandabashi T, Matsumoto
Y, Amano M, Hoshijima M, Kaibuchi K, Takeshita A: Gene transfer of dominant
negative Rho kinase suppresses neointimal formation after balloon injury
in pigs. Am J Physiol Heart Circ Physiol 278: 1744-1750, 2000
4. Hamaguchi T, Ito M, Feng J, Seko T, Koyama M, Machida H, Takase K,
Amano M, Kaibuchi K, Hartshorne DJ, Nakano T: Phosphorylation of CPI-17,
an inhibitor of myosin phosphatase, by protein kinase N. Biochem Biophys
Res Commun 274: 825-830, 2000
5. Ihara K, Shimizu T, Maesaki R, Okada K, Amano M, Kaibuchi K, Hakoshima
T: Crystallization and preliminary crystallographic analysis of the rho-
binding domain of bovine rho-kinase. Acta Crystallogr D Biol Crystallogr
56: 1042-1044, 2000
6. Inagaki N, Nishizawa M, Arimura N, Yamamoto H, Takeuchi Y, Miyamoto
E, Kaibuchi K, Inagaki M: Activation of Ca2+/calmodulin-dependent
protein kinase II within post- synaptic dendritic spines of cultured hippocampal
neurons. J Biol Chem 275: 27165-27171, 2000
7. Izawa T, Fukata Y, Kimura T, Iwamatsu A, Dohi K, Kaibuchi K: Elongation
factor-1a is a novel substrate of Rho-associated kinase. Biochem Biophys
Res Commun 278: 72-78, 2000
8. Kanai-Azuma M, Mattick JS, Kaibuchi K, Wood SA: Co-localization of
FAM and AF-6, the mammalian homologues of Drosophila faf and canoe, in
mouse eye development. Mech Dev 91: 383-386, 2000
9. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y,
Higo T, Egashira K, Takahashi S, Kaibuchi K, Takeshita A: Inhibition of
myosin phosphatase by upregulated rho-kinase plays a key role for coronary
artery spasm in a porcine model with interleukin-1ß. Circulation
101: 1319-1323, 2000
10. Kaneko T, Amano M, Maeda A, Goto H, Takahashi K, Ito M, Kaibuchi K:
Identification of calponin as a novel substrate of Rho-kinase. Biochem
Biophys Res Commun 273: 110-116, 2000
11. Kawajiri A, Itoh N, Fukata M, Nakagawa M, Yamaga M, Iwamatsu A, Kaibuchi
K: Identification of a novel ß-catenin-interacting protein. Biochem
Biophys Res Commun 273: 712-717, 2000
12. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Tamura K, Goto T, Aimoto
S, Kaibuchi K, Shiosaka S, Takeda M: Site-specific phosphorylation of
neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase
II in the apical dendrites during long-term potentiation. J Neurochem
75: 373-382, 2000
13. Miyamoto S, Baba H, Kuroda S, Kaibuchi K, Fukuda T, Maehara Y, Saito
T: Changes in E-cadherin associated with cytoplasmic molecules in well
and poorly differentiated endometrial cancer. Br J Cancer 83: 1168-1175,
2000
14. Miyata K, Shimokawa H, Kandabashi T, Higo T, Morishige K, Eto Y, Egashira
K, Kaibuchi K, Takeshita A: Rho-kinase is involved in macrophage-mediated
formation of coronary vascular lesions in pigs in vivo. Arterioscler
Thromb Vasc Biol 20: 2351-2358, 2000
15. Nakamura N, Oshiro N, Fukata Y, Amano M, Fukata M, Kuroda S, Matsuura
Y, Leung T, Lim L, Kaibuchi K: Phosphorylation of ERM proteins at filopodia
induced by Cdc42. Genes Cells 5: 571-581, 2000
16. Oude Weernink PA, Schulte P, Guo Y, Wetzel J, Amano M, Kaibuchi K,
Haverland S, Voss M, Schmidt M, Mayr GW, Jakobs KH: Stimulation of phosphatidylinositol-4-phosphate
5-kinase by Rho-kinase. J Biol Chem 275: 10168-10174, 2000
17. Royal I, Lamarche-Vane N, Lamorte L, Kaibuchi K, Park M: Activation
of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor
differentially regulates epithelial cell colony spreading and dissociation.
Mol Biol Cell 11: 1709-1725, 2000
18. Sato M, Tani E, Fujikawa H, Kaibuchi K: Involvement of rho-kinase-mediated
phosphorylation of myosin light chain in enhancement of cerebral vasospasm.
Circ Res 87: 195-200, 2000
19. Shimizu T, Ihara K, Maesaki R, Kuroda S, Kaibuchi K, Hakoshima T:
An open conformation of switch I revealed by the crystal structure of
a Mg2+-free form of RHOA complexed with GDP. Implications
for the GDP/GTP exchange mechanism. J Biol Chem 275: 18311-18317,
2000
20. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S,
Kaibuchi K, Nabeshima Y, Hama C: Synaptic development is controlled in
the periactive zones of drosophila synapses. Development 127: 4157-4168,
2000
21. Fukata M, Nakagawa M, Itho N, Kawajiri A, Yamaga M, Kuroda S, Kaibuchi
K: Involvement of IQGAP1, an effector of rac1 and cdc42 GTPases, in cell-cell
dissociation during cell scattering. Mol Cell Biol in press1
鹿川哲史（岡崎国立共同研究機構・生理学研究所）
1. Moran-Rivard L, Kagawa T, Saueressig H, Gross MK, Burrill J, Goulding
M: Evx1 is a postmitotic determinant of V0 interneuron identity in the
spinal cord. Neuron 29: 385-399, 2001
2. Wada T, Kagawa T, Ivanova A, Zalc B, Shirasaki R, Murakami F, Iemura
S, Ueno N, Ikenaka K: Dorsal spinal cord inhibits oligodendrocyte development.
Dev Biol 227: 42-55, 2000
新谷隆史（岡崎国立共同研究機構・基礎生物学研究所）
1. Suzuki R, Shintani T, Sakuta H, Kato A, Ohkawara T, Osumi N, Noda M:
Identification of RALDH-3, a novel retinaldehyde dehydrogenase, expressed
in the ventral region of the retina. Mech Dev 98:37-50, 2000
高田慎治（京都大学・大学院理学研究科）
1. Ikeya M, Takada S: Wnt-3a is required for somite specification along
anteroposterior axis of the mouse embryo and regulates cdx-1 expression.
Mech Dev in press
2. Takeda K, Yasumoto K, Takada R, Takada S, Watanabe K, Udono T, Saito
H, Takahashi K, Shibahara S: Induction of melanocyte-specific microphthalmia-associated
transcription factor by Wnt-3a. J Biol Chem 275, 14013-14016,
2000
3. Takeuchi S, Takeda K, Oishi I, Nomi M, Ikeya M, Itoh K, Tamura S, Ueda
T, Hatta T, Otani H, Terashima T, Takada S, Yamamura H, Akira S, Minami
Y: Mouse Ror2 receptor tyrosine kinase is required for the heart developmentand
limb formation. Genes Cells 5, 71-78, 2000
4. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino S, Michiue
T, Takada S, Asashima M, Kikuchi A: A novel β-catenin-binding protein
inhibits β-catenin-dependent tcf activation and axis formation. J Biol
Chem 275, 32871-32878, 2000
5. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A: Complex
formation of adenomatous polyposis voli gene product and axin facilitates
glycogen synthase kinase-3β-dependent phosphorylation of β-catenin and
down-regulates β-catenin. J Biol Chem 275, 34399-34406,
2000
6. Hino S-I, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima
M, Kikuchi A: Inhibition of the Wnt signaling pathway by Idax, a novel
Dvl-binding protein. Mol Cell Biol 21, 330-342, 2001
7. Takahashi N, Ishihara S, Takada S, Tsukita S, Nagafuchi A: Posttranscriptional
regulation of β-catenin expression is required for Wnt signaling in L
cells. Biophys Biochem Res Comm in press
高橋政代（京都大学・大学院医学研究科）
1. Nishida A, Takahashi M, Tanihara H, Nakano I, Takahashi JB, Mizoguchi
A, Ide C, Honda Y: Incorporation and differentiation of hippocampus-derived
neural stem cells transplanted in injured adult rat retina. Invest
Ophthalmol Vis Sci 41: 4268-4274, 2000
田中光一（東京医科歯科大学・難治疾患研究所）
1. Gray C, Marie H, Arora M, Tanaka K, Boyde A, Jones S, Attwell D: Glutamate
does not play a major role in controlling bone growth. J Bone Miner
Res in press
2. Yamada K, Fukaya M, Shibata T, Kurihara H, Tanaka K, Inoue Y, Watanabe
M: Dynamic transformation of Bergmann glial fibers proceeds in correlation
with dendritic outgrowth of cerebellar Purkinje cells. J Comp Neurol
418: 106-120, 2000
3. Hakuba N, Koga K, Gyo K, Usami S, Tanaka K: Exacerbation of noise-induced
hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci
20: 8750-8753, 2000
谷口雅彦（東京大学・大学院医学系研究科）
1. Aono S, Keino H, Ono T, Yasuda Y, Tokita Y, Matsui F, Taniguchi M,
Sonta S, Oohira A: Genomic organization and expression pattern of mouse
neuroglycan C in the cerebellar development. J Biol Chem 275: 337-342,
2000
2. Ito T, Kagoshima M, Sasaki Y, Li C, Udaka N, Kitsukawa T, Fujisawa
H, Taniguchi M, Yagi T, Kitamura H, Goshima Y: Repulsive axon guidance
molecule Sema3A inhibits branching morphogenesis of fetal mouse lung.
Mech Dev 97: 35-45, 2000
3. Løes S, Kettunen P, Kvinnsland IH, Taniguchi M, Fujisawa H,
Luukko K: Expression of class 3 semaphorins and neuropilin receptors in
the developing mouse tooth. Mech Dev 101: 185-188, 2001
谷藤（森本）高子（東京大学・大学院理学系研究科）
1. Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-MorimotoT,
Yuasa Y, Yoshihara Y, Nose A, Okano H: GAL4/UAS-WGA system as a
poweful tool for tracing Drosophila transsynaptic neural pathways.
J Neurosci Res 59: 94-99, 2000
坪井昭夫（東京大学・大学院理学系研究科）
1. Serizawa S, Ishii T, Nakatani H, Tsuboi A, Nagawa F, Asano M, Sudo
K, Sakagami J, Sakano H, Ijiri T, Matsuda Y, Suzuki M, Yamamori T, Iwakura
Y, Sakano H: Mutually exclusive expression of odorant receptor transgenes.
Nat Neurosci 3: 687-693, 2000
2. Ishii T, Serizawa S, Kohda A, Nakatani H, Shiroishi T, Okumura K, Iwakura
Y, Nagawa F, Tsuboi A, Sakano H: Monoallelic expression of the odourant
receptor gene and axonal projection of olfactory sensory neurones. Genes
Cells 6: 71-78, 2001
3. Sengoku S, Ishii T, Serizawa S, Nakatani H, Nagawa F, Tsuboi A, Sakano
H: Axonal projection of olfactory sensory neurons during the developmental
and regeneration processes. NeuroReport in press
仲嶋一範（東京慈恵会医科大学・DNA医学研究所）
1. Kojima T, Nakajima K, Mikoshiba K: The disabled 1 gene is disrupted
by a replacement with L1 fragment in yotari mice. Mol Brain
Res 75: 121-127, 2000
2. Yip JW, Yip YPL, Nakajima K, Capriotti C: Reelin controls position
of autonomic neurons in the spinal cord. Proc Natl Acad Sci USA
97: 8612-8616, 2000
3. Utsunomiya-Tate N, Kubo K, Tate S, Kainosho M, Katayama E, Nakajima
K, Mikoshiba K: Reelin molecules assemble together to form a large protein
complex, which is inhibited by the function-blocking CR-50 antibody. Proc
Natl Acad Sci USA 97: 9729-9734, 2000
4. Tabata H, Nakajima K: Efficient in utero gene transfer system
to the developing mouse brains using electroporation --Visualization of
neuronal migration in the developing cortex. Neuroscience in press
中島欽一（熊本大学・発生医学研究センター）
1. Nakashima K, Takizawa T, Ochiai W, Yanagisawa M, Hisatsune T, Nakafuku
M, Miyazono K, Kishimoto T, Kageyama R, Taga T: BMP2-mediated alteration
from neurogenesis to astrocytogenesis in fetal mouse brain cells. Proc
Natl Acad Sci USA in press
2. Takizawa T, Yanagisawa M, Ochiai W, Yasukawa K, Ishiguro T, Nakashima
K, Taga T: Directly linked soluble IL-6 receptor-IL-6 fusion protein induces
astrocyte differentiation from neuroepithelial cells via activation of
STAT3. Cytokine in press
3. Matsuo R, Ochiai W, Nakashima K, Taga T: A new expression cloning strategy
for isolation of substrate-specific kinases by using phosphorylation site-specific
antibody. J Immunol Methods 247: 141-151, 2001
4. Yanagisawa M, Nakashima K, Takizawa T, Ochiai W, Arakawa H, Taga T:
Signaling crosstalk underlying synergistic induction of astrocyte differentiation
by BMPs and IL-6 family of cytokines. FEBS Lett 489: 139-143,
2001
5. Kato H, Chen S, Kiyama H, Ikeda K, Kimura N, Nakashima K, Taga T: Identification
of a novel WD repeat-containing gene predominantly expressed in developing
and regenerating neurons. J Biochem (Tokyo) 128: 923-932,
2000
6. Kimura N, Matsuo R, Shibuya H, Nakashima K, Taga T: BMP2-induced apoptosis
is mediated by activation of the TAK1-p38 kinase pathway that is negatively
regulated by Smad6. J Biol Chem 275: 17647-17652, 2000
7. Kojima N, Kinoshita T, Kamiya A. Nakamura K, Nakashima K, Taga T, Miyajima
A: Cell density-dependent regulation of hepatic development by a gp130-independent
pathway. Biochem Biophys Res Commun 277: 152-158, 2000
8. Ueno M, Kimura N, Nakashima K, Saito-Ohara F, Inazawa J, Taga T: Genomic
organization, sequence and chromosomal localization of the mouse Tbr2
gene and a comparative study with Tbr1. Gene 254: 29-35,
2000
9. Yamamoto K, Masuno H, Choi M, Nakashima K, Taga T, Ooizumi H, Umesono
K, Sicinska W, VanHooke J, DeLuca HF, Yamada S: Three-dimensional modeling
of and ligand docking to vitamin D receptor ligand binding domain. Proc
Natl Acad Sci USA 97: 1467-1472, 2000
10. Yanagisawa M, Nakashima K, Arakawa H, Ikenaka K, Yoshida K, Kishimoto
T, Hisatsune T, Taga T: Astrocyte differentiation of fetal neuroepithelial
cells by interleukin-11 via activation of a common cytokine signal transducer,
gp130, and a transcription factor, STAT3. J Neurochem 74:
1498-1504, 2000
中山耕造（信州大学・医学部）
1. Lee J, Nakane Y, Koshikawa N, Nakayama K, Hayashi M, Takenaga K: Characterization
of a zinc finger protein ZAN75: Nuclear localization signal, transcriptional
activator activity, and expression during neuronal differentiation of
P19 cells. DNA Cell Biol 19: 227-234, 2000
2. Masumoto J, Taniguchi S, Nakayama K, Ayukawa K, Sagara J: Murine ortholog
of ASC, a CARD-containing protein, self-associates and exhibitsrestricted
distribution in developing mouse embryos. Exp Cell Res 262: 128-133,
2001
3. Sugane K, Nakayama K: Diagnosis of Toxoplasma meningoencephalitis in
a non-AIDS patient using PCR. J Infect in press
4. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima
M, Nikaidou T, Nakayama K, Kiyosawa K: Pancreatitis associated with elevated
levels of IgG4 in serum. N Engl J Med in press
5. Kawa S, Nikaido T, Unno H, Usuda N, Nakayama K, Kiyosawa K: Growth
inhibition and differentiation of pancreatic cancer cell lines by PPAR
ligand troglitazone through the up-expression of WAF1/CIP1/p21. Pancreas
in press
6. Li W, Okano A, Tiana Q, Nakayama K, Furihata T, Nawa H, Suzuki T: Characterization
of a novel synGAP isoform, synGAP-β. J Biol Chem in press
根岸学（京都大学・大学院生命科学研究科）
1. Nakamura K, Kaneko T, Yamashita Y, Hasegawa H, Katoh H, Negishi M:
Immunohistochemical localization of prostaglandin EP3 receptor in the
rat nervous system. J Comp Neurol 421: 543-569, 2000
2. Fujita H, Katoh H, Hasegawa H, Yasui H, Aoki J, Yamaguchi Y, Negishi
M: Molecular decipherment of Rho effector pathways regulating tight-junction
permeability. Biochem J 346: 617-622, 2000
3. Hasegawa H, Katoh H., Yamaguchi Y, Nakamura K, Futakawa S, Negishi
M: Different membrane targeting of prostaglandin EP3 receptor isoforms
dependent on their carboxy-terminal tail structures. FEBS Lett
473: 76-80, 2000
4. Yamaguchi Y, Katoh H, Yasui H, Aoki J, Nakamura K, Negishi M: Gα12
and Gα13 inhibit Ca2+-dependent exocytosis through Rho/Rho-associated
kinase-dependent pathway. J Neurochem 75: 708-717, 2000
5. Hasegawa H, Katoh H, Fujita H, Mori K, Negishi M: Receptor isoform-specific
interaction of prostaglandin EP3 receptor with muskelin. Biochem Biophys
Res Commun 276: 350-354, 2000
6. Katoh H, Yasui H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M:
Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells.
Mol Cell Biol 20: 7378-7387, 2000
7. Aoki J, Katoh H, Mori K, Negishi M: Rnd1, a novel Rho family GTPase,
induces the formation of neurite processes in PC12 cells. Biochem Biophys
Res Commun 278: 604-608, 2000
8. Yasui H, Katoh H, Yamaguchi Y, Aoki J, Fujita H, Mori K, Negishi M:
Different responses to NGF and EGF in neurite outgrowth of PC12 cells
are determined by Rac1 activation systems. J Biol Chem in press
浜千尋（国立精神神経センター・神経研究所）
1. Awasaki T, Saito M, Sone M, Suzuki E, Sakai R, Ito K, Hama C: The Drosophila
Trio plays an essential role in patterning of axons by regulating their
directional extension. Neuron 26: 119-131, 2000
2. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata F, Kuroda S, Kaibuchi
K, Nabeshima Y, Hama C: Synaptic development is controlled in the periactive
zones of Drosophila synapses. Development 127: 4157-4168,
2000
久永真市（東京都立大学・理学研究科）
1. Tokuoka H, Saito T, Yorifuji H, Kishimoto T, Hisanaga S: BDNF-induced
phosphorylation of neurofilament-H subunit in primary culture of rat cortical
neurons. J Cell Sci 113: 1059-1068, 2000
2. Kitazawa H, Iida J, Uchida A, Haino-Fukushima K, Itoh TJ, Hotani H,
Ookata K, Murofushi H, Bulinski JC, Kishimoto T, Hisanaga S: Ser787 in
the proline-rich region of human MAP4 is a critical phosphorylation site
that reduces the microtubule polymerization activity. Cell Struct Funct
25: 33-39, 2000
3. Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S:
Calpain-dependent proteolytic cleavage of the p35 CDK5 activtor to p25.
J Biol Chem 275: 17166-17172, 2000
4. Taniguchi S, Fujita Y, Takahashi H, Hayashi S, Kakita A, Murayama S,
Saido T, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation
of p35 to p25 in postmortem human and rat brains. FEBS lett 489:
46-50, 2001
5. Uchida A, Komiya Y, Tashiro T, Yorifuji H, Kishimoto T, Nabeshima Y,
Hisanaga S: The neurofilament of Klotho, the mutant mouse prepaturely
displaying symptoms resembling human aging. J Neurosci Res in press
6. Bibb JA, Nishi A, O’Callaghan JP, Ule J, Lan M, Snyder GL, Horiuchi
A, Saito T, Hisanaga S, Czernikj AJ, Nairn AC, Greengard P: Phosphorylation
of protein phosphatase inhibitor-I by Cdk5. J Biol Chem in press
別所康全（京都大学・ウイルス研究所）
1. Bae S, Bessho Y, Hojo M, Kageyama R: The bHLH gene Hes6, an inhibitor
of Hes1, promotes neuronal differentiation. Development 127: 2933-2943,
2000
2. Hirata H, Ohtsuka T, Bessho Y, Kageyama R: Generation of structurally
and functionally distinct factors from the basic helix-loop-helix gene
Hes3 by alternative first exons. J Biol Chem 275: 19083-19089,
2000
3. Satow T, Bae SK, Inoue T, Inoue C, Miyoshi G, Tomita K, Bessho Y, Hashimoto
N, Kageyama R: The basic helix-loop-helix gene hesr2 promotes gliogenesis
in mouse. J Neurosci 21:1265-1273, 2001
星野幹雄（京都大学・大学院医学研究科）
1. Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi
K, Nabeshima Y, Hama C: Synaptic development is controlled in the periactive
zones of Drosophila synapses. Development 127:4157-4168, 2000
前川昌平（神戸大学・大学院自然科学研究科）
1. Miyata S, Funatsu N, Matsunaga W, Kiyohara T, Sokawa Y, Maekawa S:
Expression of the IgLON cell adhesion molecules, Kilon and OBCAM, in the
hypothalamic magnocellular neurons. J Comp Neurol 424: 74-85, 2000
2. Uematsu A, Kumanogoh H, Yasaka K, Sokawa, J, Orito A, Sokawa Y, Maekawa
S: Specific localization of the vacuolar H+-ATPase in the Triton
insoluble low-density fraction (raft) of bovine chromaffin granule membrane.
J Biochem Mol Biol Biophys 4: 395-400, 2000
3. Ohira K, Maekawa S, Hayashi M: Absence of Trk B and insulin receptorB
in the Triton insoluble low-density fraction (raft) of rat brain. NeuroReport
11: 1307-1311, 2000
4. Funatsu N, Kumanogoh H, Sokawa J, Maekawa S: Identification of gelsolin
as a actin regulatory activity of a Triton insoluble low density fraction
of bovine brain. Neurosci Res 36: 311-317, 2000
5.Kashihara M, Miyata S, Kumanogoh H, Funatsu N, Matsunaga T, Kiyohara
T, Sokawa Y, Maekawa S: Changes in the localization of NAP-22, a calmodulin
binding membrane protein, during the development of neuronal polarity.
Neurosci Res 37: 315-325, 2000
6. Orito A, Kumanogoh H, Yasaka K, Sokawa J, Hidaka H, Sokawa Y, Maekawa
S: Calcium-dependent association of annexin VI, protein kinase Ca, and
neurocalcina, on the raft fraction derived from the synaptic plasma membrane
of rat brain. J Neurosci Res in press
7. Kumanogoh H, Miyata S, Sokwa Y, Maekawa S: Biochemical and morphological
analysis on the localization of Rac1 in neurons. Neurosci Res in
press
8. Maekawa S., Morii H, Kumanogoh H, Sano M, Naruse Y, Sokawa Y, Mori
N: Localization of neuronal growth-assiciated microtubule-destabilizing
factor SCG10 in brain-derived raft membrane microdomains. J Biochem
(Tokyo) in press
9. Miyata S, Takamatsu H, Maekawa S, Matsumoto N, Watanabe K, Kiyohara
T, Hatton GI: Plasticity of neurohypophysial terminals with increased
hormonal release during dehydration:ultrastructural and biochemical analyses.
J Comp Neurol in press
水野健作（東北大学・大学院理学研究科）
1. Ohashi K, Nagata K, Maekawa M, Ishizaki T, Narumiya S, Mizuno K: Rho-associated
kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine-508
within the activation loop. J Biol Chem 275: 3577-3582, 2000
2. Bito H, Furuyashiki T, Ishihara H, Shibasaki Y, Ohashi K, Mizuno K,
Maekawa M, Ishizaki T, Narumiya S: A critical role for a Rho-associated
kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons.
Neuron 26: 431-441, 2000
3. Ohashi K, Hosoya T, Takahashi K, Hing H, Mizuno K: A Drosophila
LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization.
Biochem Biophys Res Commun 276: 1178-1185, 2000
4. Amano T, Tanabe K, Eto T, Narumiya S, Mizuno K: LIM-kinase 2 induces
the formation of actin stress fibers, focal adhesions and membrane blebs,
dependent on its activation by Rho-associated kinase-catalyzed phosphorylation
of threonine-505. Biochem J 354: 149-159, 2001
5. Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K: Cofilin
phosphorylation by protein kinase TESK1 and its role in integrin-mediated
actin remodeling. Mol Biol Cell in press
村上富士夫（大阪大学・大学院基礎工学研究科）
1. Tashiro Y, Endo T, Shirasaki , Miyahara M, Heizmann CW, Murakami F:
Afferents of cranial sensory ganglia pathfind to their target independent
of the site of entry into the hindbrain. J Comp Neurol 417: 491-500,
2000
2. Nakamura S, Ito Y, Shirasaki R, Murakami F: Local directional cues
control growth polarity of dopaminergic axons along the rostrocaudal axis.
J Neurosci 20: 4112-4119, 2000
3. Wada T, Kagawa T, Ivanova A, Zalc B, Shirasaki R, Murakami F, Iemura
S, Ueno N, Ikenaka K: Dorsal spinal cord inhibits oligodendrocyte development.
Dev Biol 227: 42-55, 2000
4. Song W-J, Baba Y, Otsuka T, Murakami F: Characterization of Ca2+
channels in rat subthalamic nucleus neurons. J Neurophysiol
84: 2630-2637, 2000
5. Yamamoto N, Inui K, Matsuyama Y, Harada A, Hanamura K, Murakami F,
Ruthazer ES, Rutishauser U, Seki T: Inhibitory mechanism by polysialic
acid for lamina-specific branch formation of thalamocortical axons. J
Neurosci 20: 9145-9151, 2000
6. Tashiro Y, Miyahara M, Shirasaki R, Okabe M, Heizmann CW, Murakami
F: Local nonpermissive and oriented permissive cues guide vestibular axons
to the cerebellum. Development in press
吉原良浩（理化学研究所・脳科学総合研究センター）
1. Tian L, Nyman H, Kilgannon P, Yoshihara Y, Mori K, Andersson LC, Kaukinen
S, Rauvala H, Gallatin WM, Gahmberg CG: Intercellular adhesion molecule-5
induces dendritic outgrowth by homophiloc adhesion. J Cell Biol
150: 243-252, 2000
2. Tian L, Kilgannon P, Yoshihara Y, Mori K, Gallatin WM, Carpen O, Gahmberg
CG: Binding of T lymphocytes to hippocampal neurons through ICAM-5 (telencephalin)
and characterization of its interaction with leukocyte integrin CD11a/CD18.
Eur J Immunol 30: 810-818, 2000
3. Nagao H, Yoshihara Y, Mitsui S, Fujisawa H, Mori K: Two mirror-image
sensory maps with domain organization in the mouse main olfactory bulb.
NeuroReport 11: 3023-3027, 2000
4. Tabuchi K, Sawamoto K, Suzuki E, Ozaki K, Sone M, Hama C, Tanifuji-MorimotoT,
Yuasa Y, Yoshihara Y, Nose A, Okano H: GAL4/UAS-WGA system as a
poweful tool for tracing Drosophila transsynaptic neural pathways.
J Neurosci Res 59: 94-99, 2000
5. Yoshihara Y, Nagao H, Mori K: Sniffing out odors with multiple dendrites.
Science 291: 835-837, 2000
6. Mori K, von Campenhausen H, Yoshihara Y: Zonal organization of the
mammalian main and accessory olfactory bulb. Phil Trans Biol Sci
in press
若松義雄（東北大学・大学院医学系研究科）
1. Wakamatsu Y, Maynard TM, Weston JA: Fate determination of neural crest
cells by NOTCH-mediated lateral inhibition and asymmetrical cell division
during gangliogenesis. Development 127: 2811-2821, 2000
2. Maynard TM, Wakamatsu Y, Weston JA: Cell interactions within nascent
neural crest cell populations transiently promote death of neurogenic
precursors. Development 127: 4561-4572, 2000
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