業績集

平成12年度
 　 　 　
A01班
A02班
A03班
A04班
B01班
B02班
B03班
A04班

辻省次（新潟大学・脳研究所）

1. Yamada M, Piao Y-S, Toyoshima Y, Tsuji S, Takahashi H: Ubiquitinated filamentous inclusions in cerebellar dentate nucleus neurons in dentatorubral-pallidoluysian atrophy contain expanded polyglutamine stretches. Acta Neuropathol 99: 615-618, 2000

2. Shimohata T, Nakajima T, Yamada M, Uchida C, Onodera O, Naruse S, Kimura T, Koide R, Nozaki K, Sano Y, Ishiguro H, Sakoe K, Ooshima T, Sato A, Ikeuchi T, Oyake M, Sato T, Aoyagi Y, Hozumi I, Nagatsu T, Takiyama Y, Nishizawa M, Goto J, Kanazawa I, Davidson I, Tanese N, Takahashi H, Tsuji S: Expanded polyglutamine stretches associated with CAG repeat diseases interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet 26: 29-35, 2000

3. Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji S: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer’s disease. Neurology 54: 2319-2321, 2000

4. Tomita H, Nagamitsu S, Wakui K, Fukushima Y, Yamada K, Sadamatsu M, Masui A, Konishi T, Matsuishi T, Aihara M, Shimizu K, Hashimoto K, Mineta H, Matsushima M, Tsujita T, Saito M, Tanaka H, Tsuji S, Takagi T, Nakamura Y, Nanko S, Kato N, Nakane Y, Niikawa N: Paroxysmal kinesigenic chorcoathetosis locus maps to chromosome 16p11.2-q12.1. Am J Hum Genet in press

5. Tsuchiya K, Shintani S, Nakabayashi H, Kikugawa K, Nakano R, Haga C, Nakano I, Ikeda K, Tsuji S: Familial amyotrophic lateral sclerosis with onset in bulbar sign, benign clinical course, and Bunina bodies: a clinical, genetic, and pathological study of a Japanese family. Acta Neuropahtol in press

6. Shibasaki Y, Tanaka H, Iwabuchi K, Kawasaki S, Kondo H, Uekawa K, Ueda M, Kamiya T, Katayama Y, Nakamura A, Takashima H, Nakagawa M, Masuda M, Utsumi H, Nakamuro T, Tada K, Kurohara K, Inoue K, Koike F, Sakai T, Tsuji S, Kobayashi H: Linkage of autosomal recessive spatic paraplegia with mental impairment and thin corpus callosum to chromosome 15q13-15. Ann Neurol in press

7. Saito M, Maruyama M, Ikeuchi K, Kondo H, Ishikawa A, Yuasa T, Tsuji S: Autosomal recessive juvenile parkinsonism. Brain Dev in press

池田穰衛（東海大学総合医学研究所）

1. Saitoh Y, Miyamoto N, Okada T, Gondo Y, Shoguchi-Miyata J, Hadano S, Ikeda J-E: The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter. Genomics 69: 62-85, 2000

2. Osuga H, Osuga S, Wang F, Fetni R, Hogan M J, Slack R S, Hakim A M, Ikeda J-E, Park S D: Cyclin-dependent kinases as a therapeutic target for stroke. Proc Natl Acad Sci USA 97:10254-10259, 2000

3. Osuga H, Onoe K, Sakai H, Otomo A, Yoshii F, Shinohara Y, Ikeda J-E: The upregulation of neuronal apoptosis inhibitory protein in rat permanent focal ischemia model. J Stroke Cerebrovasc Dis 19: 345-346, 2000

4. Onoe K, Osuga H, Yoshii F, Shinohara Y, Ikeda J-E: Establishment of a focal cerebral ischemia model in Goettingen/CSK miniature swine. J Stroke Cerebrovasc Dis 19: 347-348, 2000

5. Matsutyama N, Hadano S, Onoe K, Osuga H, Showguchi-Miyata J, Gondo Y, Ikeda J-E: Identification and characterization of the miniature pig Huntington's disease gene homolog: evidence for conservation and polymorphism in the CAG triplet repeat. Genomics 69: 72-85, 2000

6. Hadano S, Yanagisawa Y, Skaug J, Fichter K, Nasir J, Martindale D, Koop BF, Scherer SW, Nicholson DW, Rauleau GA, Ikeda J-E, Hayden MR: Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: Candidate genes for ALS2. Genomics 71: 200-213, 2000

岩坪威（東京大学・大学院薬学系研究科）

1. Okochi M, Walter J, Koyama A, Nakajo S, Baba M, Iwatsubo T, Meijer L, Kahle P, Haass C: Constitutive phosphorylation of the Parkinson’s disease associated a-synuclein. J Biol Chem 275: 390-397, 2000

2. Wakabayashi K, Fukushima T, Koide R, Horikawa Y, Hasegawa M, Watanabe Y, Noda T, Eguchi I, Morita T, Yoshimoto M, Iwatsubo T, Takahashi H: Juvenile-onset generalized neuroaxonal dystrophy (Hallervorden-Spatz disese) with diffuse neurofibrillary and Lewy body pathology. Acta Neuropathol 99: 331-336, 2000

3. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-calpain. Int J Mol Med 5: 269-273, 2000

4. Nishizawa T, Nagao T, Iwatsubo T, Forte JG, Urushidani T: Molecular cloning and characterization of a novel CLIC-related protein, parchorin, expressed in water-secreting cells. J Biol Chem 275: 11164-11173, 2000

5. Yasuda M, Takamatsu J, D’Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Iwatsubo T, Goedert M, Schellenberg G, Tanaka C: A novel mutation at position +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47: 422-429, 2000

6. Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of tau gene. Neurology 54: 1787-1795, 2000

7. Saura CA, Tomita T, Soriano S, Takahashi M, Leem J-Y, Honda T, Koo EH, Iwatsubo T, Thinakaran G: The non-conserved hydrophilic loop domain of presenilin is neither required for presenilin endoproteolysis nor enhanced Aβ42 production mediated by FAD-linked PS variants. J Biol Chem 275: 17136-17142, 2000

8. Yamagata K, Urakami K, Wakutani Y, Adachi Y, Iwatsubo T, Mann DMA, Sato K, Nakashima K: Increased levels of apolipoprotein E mRNA in the brains of patients with Down’s syndrome. Alzheimer Report 3: 77-82, 2000

9. Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DMA, Hyman BT, Iwatsubo T: Age-related amyloid β deposition in transgenic mice overexpressing both presenilin 1 and amyloid βprecursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157: 331-339, 2000

10. Yamazaki M, Arai Y, Baba M, Iwatsubo T, Mori O, Katayama Y, Oyanagi K: a-synuclein inclusions in amygdala in the brains of patients with Parkinsonism-Dementia Complex of Guam. J Neuropathol Exp Neurol 59: 585-591, 2000

11. Wakabayashi K, Shibasaki Y, Hasegawa M, Horikawa Y, Soma Y, Hayashi S, Morita T, Iwatsubo T, Takahashi H: Primary progressive aphasia with focal glial tauopathy. Neuropathol Appl Neurobiol 26: 477-481, 2000

12. Lambert JC, Mann D, Goumidi L, Harris J, Pasquier F, Frigard B, Cottel D, Lendon C, Iwatsubo T, Amouyel P, Chartier-Harlin: A FE65 polymorphism associated with risk of developing sporadic late-onset Alzheimer's disease but not with Ab loading in brains. Neurosci Lett 293: 29-32, 2000

13. Takahashi M, Dore S, Ferris CD, Tomita T, Sawa A, Wolosker H, Borchelt DR, Iwatsubo T, Kim S-H, Thinakaran G, Sisodia SS, Snyder SH: Amyloid precursor proteins inhibit heme oxygenase activity and augument neurotoxicity in Alzheimer’s disease. Neuron 28: 461-473, 2000

14. Pickering-Brown S, Baker M, Yen S-H, Liu W-K, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, Hutton M: Pick’s disease is associated with mutations in the tau gene. Ann Neurol 48: 859-867, 2000

15. Arai H, Higuchi M, Okamura N, Morikawa Y, Higuchi S, Iwatsubo T, Vanmechelen E, Vanderstichele H, Trojanowski JQ, Sasaki H: Molecular and biological markers in the diagnosis of monitoring the progression of Alzheimer's disease. Neurobiol Alzheimer’s Dis in press

16. Piao Y-S, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi T: Co-localization of a-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol in press

17. Kuzuhara S, Kokubo Y, Sasaki R, Narita Y, Yabana T, Hasegawa M, Iwatsubo T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii peninsula of Japan: clinical and neuropathological study and tau analysis. Ann Neurol in press

18. Taniguchi S, Fujita Y, Hayashi S, Kakita A, Takahashi H, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Calpain-mediated degradation of p35 to p25 in postmortem human and rat brains. FEBS lett in press

祖父江元（名古屋大学・大学院医学研究科）

1. Takeuchi H, Misu K, Hattori N, Nagamatsu M, Sobue G: Immunoglobulin therapy for idiopathic chronic sensory ataxic neuropathy. Neurology 54: 1008-1010, 2000

2. Kobayashi Y, Kume A, Li M, Doyu M, Hata M, Ohtsuka K. Sobue G: Chaperones, Hsp70 and Hsp40, suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract. J Biol Chem 275: 8772-8778, 2000

3. Misu K, Hattori N, Ando Y, Ikeda S, Sobue G: Anticipation in early-but not late onset familial amyloid polyneurolathy (TTR Met 30) in Japan. Neurology 55: 451-452, 2000

4. Terao S, Miura N, Takeda A, Takahashi A, Miura T, Sobue G: Course and distribution of facial corticobulbar tract fibres in the lower brain stem. J Neurol Neurosurg Psychiat 69: 262-265, 2000

5. Terao S, Osano Y, Fukuona T, Miura N, Mitsuma T, Sobue G: Coexisting vertical and horizontal one and a half syndrome. J Neurol Neurosurg Psychiat 69: 401-402, 2000

6. Sawada K, Doyu M, Tanaka F, Sobue G, Kato K: Detection of triplet repeat expansion in the human genome by use of hybridization signal intensity. Anal Biochem 286: 59-66, 2000

7. Misu K, Yoshihara T, Shikama Y, Awaki E, Yamamoto M, Hattori N, Hirayama M, Takegami T, Nakashima K, Sobue G: An axonal form of Charcot-Marie-Tooth disease showing distinctive features in association with mutations in the periheral myelin protein zero gene (Thr124Met or Asp75Val). J Neurol Neurosurg Psychiat 69: 806-811, 2000

8. McCampbell A, Taylor JP, Taye AA, Robitschek J, Li M, Walcott J, Merry D, Chai Y, Paulson H, Sobue G, FischbeckK H: CREB-binding protein sequestration by expanded polyglutamine. Hum Mol Genet 9: 2197-2202, 2000

9. Watanabe H, Tanaka F, Doyu M, Riku S, Yoshida M, Hashizume Y, Sobue G: Differential somatic CAG repeat instability in variable brain cell lineage in dentatorubral pallidoluysian atrophy (DRPLA): a laser-captured microdissection (LCM)-based analysis. Hum Genet 107: 452-457, 2000

10. Doyu M, Sawada K, Mitsuma N, Niwa J, Yoshimoto M, Fujii Y, Sobue G, Kato K: Gene expression profile in Alzheimer’s brain screened by molecular indexing. Mol Brain Res in press

11. Shanlou Q, Iwashita T, Furukawa T, Yamamoto M, Sobue G, Takahashi M: Differential effects of LAR on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant protein. J Biol Chem in press

12. Kato M, Iwashita T, Akhand AA, Kawamoto Y, Senga T, Sobue G, Yamamoto M, Hamaguchi M, Takahashi M, Nakashima I: Evidence of both inter- and intra-molecular cooperation for full catalytic activity of RET kinase. Cancer Res in press

13. Koike H, Mori K, Misu K, Hattori N, Ito H, Hirayama M, Sobue G: Painful alcoholic polyneuropathy with predominant small-fiber loss and normal thiamine status. Neurology in press

青崎敏彦（東京都老人総合研究所）

1. Suzuki T, Miura M, Nishimura K, Aosaki T: Dopamine-dependent synaptic plasticity in the striatal cholinergic interneurons. J Neurosci in press

石川欽也（東京医科歯科大学・医学部付属病院）

1. Ishikawa K, Nagaoka U, Takashima M, Yoshizawa K, Yoshizawa T, Ishikawa M, Yamawaki T, Shoji S, Mizusawa H: A gene on SCA4 locus causes dominantly inherited pure cerebellar ataxia. Neurology 54: 1971-1975, 2000

2. Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T: Spinocerebellar ataxia type 6 mutation alters P-type calcium channel function. J Biol Chem 275: 10893-10898, 2000

3. Sasaki J, Ishikawa K, Kobayashi K, Kondo-Iida E, Fukayama M, Mizusawa H, Takashima S, Sakakihara Y, Nakamura Y, Toda T: Neuronal expression of the fukutin gene. Hum Mol Genet 9: 371-376, 2000

4. Yang Q, Hashizume Y, Yoshida M, Wang Y, Goto Y, Mitsuma N, Ishikawa K, Mizusawa H: Morphological Purkinje cell changes in spinocerebellar ataxia type 6. Acta Neuropathol 100: 371-376, 2000

5. Fujigasaki H, Uchihara T, Koyano S, Iwabuchi K, Yagishita S, Makifuchi T, Nakamura A, Ishida K, Toru S, Hirai S, Ishikawa K, Tanabe T, Mizusawa H: Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains. Exp Neurol 165: 248-256, 2000

6. Takashima M, Ishikawa K, Nagaoka U, Shoji S, Mizusawa H: A linkage dysequilibrium at the candidate gene locus for the 16q-linked autosomal dominant cerebellar ataxia type III in Japan. Hum Genet in press. 

石黒啓司（藤田保健衛生大学・総合医科学研究所）

1. Nakano N, Higashiyama S, Kajihara K, Endo T, Ishiguro H, Yamada K, Nagatsu T, Taniguchi N: NTAKalpha and beta isoforms stimulate brest tumor cell growth by means of different receptor combinations. J Biochem (Tokyo) 127: 925-930, 2000

2. Yamada K, Ichino N, Nishii K, Sawada H, Higashiyama S, Ishiguro H, Nagatsu T: Characterization of the human NTAK gene structure and distribution of the isoform for rat NTAK mRNA. Gene 255: 15-24, 2000

3. Shimohata T, Nakajima T, Yamada M, Uchida C, Onodera O, Naruse S, Kimura T, Koide R, Nozaki K, Sano Y, Ishiguro H, Sakoe K, Ooshima T, Sato A, Ikeuchi T, Oyake M, Sato T, Aoyagi Y, Hozumi I, Nagatsu T, Takiyama Y, Nishizawa M, Goto J, Kanazawa I, Davidson I, Tanese N, Takahashi H, Tsuji S: Expanded polyglutamine stretches associated with CAG repeat diseases interact with TAFII130, interfering with CREB-dependent transcription. Nat Genet 26: 29-35, 2000

4. Nagao Y, Ishiguro H, Nukina N: DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts. Biochim Biophys Acta 1502: 247-256, 2000

5. Tokita Y, Keino H, Matsui F, Aono S, Ishiguro H, Higashiyama S, Oohira A: Regulation of neuregulin expression in the injured rat brain and cultured astrocytes. J Neurosci 21: 1257-1264, 2001

大野耕策（鳥取大学・医学部）

1. Tsukamoto H, Yamamoto T, Nishigaki T, Sakai N, Nanba E, Ninomiya H, Ohno K, Inui K, Okada S: SSCP analysis by RT-PCR for the prenatal diagnosis of Niemann-Pick disease type C. Prenat Diagn 21: 55-57, 2001

2. Sawamura N, Gong J-S, Garver WS, Ninomiya H, Ohno K, Yanagisawa K, Michikawa M: Site-specific phosphorylation of tau accompamed by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C model mice. J Biol Chem in press

3. Yamamoto T, Ninomiya H, Matasumoto M, Ohta Y, Nanba E, Tsutsumi Y, Yamakawa K, Millat G, Vanier MT, Pentchev PG, Ohno K: Genotype-phenotype relationship of Niemann-Pick disease type C: a possible correlation between clinical onsets and levels of NPC1 protein in isolated skin fibroblasts. J Med Genet 37: 707-711, 2000.

小池達郎（北海道大学・大学院理学研究科）

1. Koike T, Ninomiya T: Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro. NeuroReport 11: 151-155, 2000

2. Koike T, Tanaka S, Oda T, Ninomiya T: Sodium overload through voltage-dependent Na+ channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro. Brain Res Bull 51: 345-355, 2000

3. Ikegami K, Koike T: Membrane depolarization-mediated survival of sympathetic neurons through both PI-3 kinase and CAM kinase II dependent pathways. Brain Res 886: 218-226, 2000

4. Tanaka S, Kato H, Koike T: Microglial Response Factor (MRF-1): constitutive expression in ramified microglia and up-regulation upon necrotic neuronal death. Zool Sci 17: 571-578, 2000

5. Satoh T, Furuta K, Tomokiyo K, Nakatsuka D, Tanikawa M, Nakanishi M, Miura M, Tanaka S, Koike T, Hatanaka H, Ikura K, Suzuki M, Watanabe Y: Facilitatory roles of novel compounds designed from cyclopentenone prostaglandins on neurite outgrowth-promoting activities of nerve growth factor. J Neurochem 75: 1092-1102, 2000

6. Kato H, Tanaka S, Oikawa T, Koike T, Takahashi A, Itoyama Y: Expression of microglial response-factor-1 in microglia and macrophages following cerebral ischemia in the rat. Brain Res 882: 206-211, 2000

7. Origasa M, Tanaka S，Suzuki K, Tone S, Lim B, Koike T: Activation of a novel microglial gene encoding a lysosomal membrane protein in response to neuronal apoptosis. Mol Brain Res 88: 1-13, 2001

小阪 淳（岡山大学・医学部）

1. Shibuta S, Kosaka J, Inoue T, Shimizu T, Tomi K, Mashimo T: The influence of the timing administration of thiopentone sodium on nitric oxide-mediated neurotoxicity in vitro. J Neurol Sci 174: 9-15, 2000

坂口末廣（長崎大学・大学院医学研究科）

1. Deli MA, Sakaguchi S, Nakaoke R, Abraham CS, Takahata H, Kopacek J, Shigematsu K, Katamine S, Niwa N: PrP fragment 106-126 is toxic to cerebral endothelial cells expressing PrPC. NeuroReport 11: 3931-3936, 2000

2. Li A, Sakaguchi S, Shigematsu S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S: Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic to Purkinje cell degeneration. Am J Pathol 157: 1447-1452, 2000

3. Nakaoke R, Sakaguchi S, Atarashi R, Nishida N, Arima K, Shigematsu K, Katamine S: Early appearance but lagged accumulation of detergent-insoluble prion protein in the brains of mice inoculated with a mouse-adapted Creutzfeldt-Jakob disease agent. Cell Mol Neurobiol 20: 717-730, 2000

4. Li A, Sakaguchi S, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Shigematsu K: Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene. Cell Mol Neurobiol 20: 553-567, 2000

5. Kopacek J, Sakaguchi S, Shigematsu K, Nishida N, Atarashi R, Nakaoke R, Moriuchi R, Niwa M, Katamine S: Upregulation of the genes encoding lysosomal hydrolases, a perforin-like protein, and peroxidases in the brains of mice affected with an experimental prion disease. J Virol 74: 411-417, 2000

木山博資（旭川医科大学・医学部）

1. Namikawa K, Honma M, Abe K, Takeda M, Mansur K, Obata t, Miwa A, Okado H, Kiyama H: Akt/PKB prevents injury-induced motor neuron death and accelerates axonal regeneration. J Neurosci 20: 2875-2886, 2000

2. Kato H, Allen N, Emson PC, Kiyama H: GAP-43 N-terminal translocation signal targetss beta-galactosidase to developing axons in a pan-neuronal transgenic mouse line. Dev Brain Res 121:109-112, 2000

3. Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H: Damage induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Proc Natl Acad Sci USA 97: 4345-4350, 2000

4. Takano R, Hisahara S, Namikawa K, Kiyama H, Okano H, Miura M: Nerve growth factor protects oligodendrocytes from TNF-a-induced injury through Akt-mediated signaling mechanisms. J Biol Chem 275: 16360-16365, 2000

5. Takeda M, Kato H, Takamiya A, Yoshida A, Kiyama H: Injury specific expression of activating transcription factor-3 (ATF-3) in nerve injured retinal ganglion cells, and its co-localized expression with phosphorylated c-Jun. Invest Ophth Vis Sci 41: 2412-2421, 2000

6. Tanabe K, Tachibana T, Yamashita T, Che YH, Yoneda Y, Ochi T, Tohyama M, Yoshikawa T, Kiyama H: The small GTP-binding protein TC10 promotes growth cone-like formation and nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci 20: 4138-4144, 2000

7. Nakagomi S, Kiryu-Seo S, Kiyama H: Endothelin converting enzymes and endothelin receptor B mRNAs are expressed in different neural cell species and these mRNAs are coordinately induced in neurons and astrocytes respectively following nerve injury. Neuroscience 101: 441-449, 2000

8. Gesase AP, Kiyama H: Morphological changes and expression of protein kinase CK2 beta subunit in the microglia after hypoglossal nerve transection. J Neurocytol 29: 61-66, 2000

9. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem in press

10. Ishida-Yamamoto A, Kato H, Kiyama H, Armstrong DK, Munro CS, Eady RA, Nakamura S, Kinouchi M, Takahashi H, Iizuka H: Mutant loricrin is not crosslinked into the cornified cell envelope but is translocated into the nucleus in loricrin keratoderma. J Invest Dermatol 115: 1088-1094, 2000

下濱 俊（京都大学・大学院医学研究科）

1. Kume T, Nishikawa H, Tomioka H, Katsuki H, Akaike A, Kaneko S, Maeda T, Kihara T, Shimohama S: p75-mediated neuroprotection by NGF against glutamate cytotoxicity in cortical cultures. Brain Res 852: 279- 289, 2000

2. Kageyama T, Oeda T, Imura H, Kawamata J, Suzuki S, Tomimoto H, Shimohama S: Coexistence of expanded CAG repeats in the MJD1a and DRPLA genes. Neurology 54: 265-266, 2000

3. Yamamoto K, Hashimoto K, Isomura Y, Shimohama S, Kato N: An IP3-assisted form of Ca2+-induced Ca2+ release in neocortical neurons. NeuroReport 11: 535-539, 2000

4. Sawada H, Ibi M, Kihara T, Urushitani M, Nakanishi M, Akaike A, Shimohama S: Neuroprotective mechanism of glial cell line-derived neurotrophic factor in mesencephalic neurons. J Neurochem 74: 1175-1184, 2000

5. Honda K, Sawada H, Kihara T, Urushitani M, Nakamizo T, Akaike A, Shimohama S: Phosphatidylinositol 3- kinase mediates neuroprotection by estrogen in cultured cortical neurons. J Neurosci Res 60: 321-327, 2000

6. Sawada H, Ibi M, Kihara T, Urushitani M, Honda A, Akaike A, Shimohama S: Mechanisms of antiapoptotic effects of estrogen in nigral dopaminergic neurons. FASEB J 14: 1202-1214, 2000

7. Tanino H, Shimohama S, Sasaki Y, Sumida Y, Fujimoto S: Increase in phospholipase C-d1 protein levels in aluminum-treated rat brains. Biochem Biophys Res Commun 271: 620-625, 2000

8. Shimohama S, Tanino H, Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S: Activation of NADPH oxidase in Alzheimer’s disease brains. Biochem Biophys Res Commun 273: 5-9, 2000

9. Urushitani M, Inoue R, Nakamizo T, Honda K, Kihara T, Sawada H, Akaike A, Shibasaki H, Shimohama S: Neuroprotective effect of cyclic GMP against radical-induced toxicity in cultured spinal motor neurons. J Neurosci Res 61: 443-448, 2000

10. Kageyama T, Nakamura M, Matsuo A, Yamasaki Y, Takakura Y, Hashida M, Kanai Y, Naito M, Tsuruo T, Minato N, Shimohama S: The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res 879: 115-121, 2000

11. Imura T, Shimohama S: Opposing effects of adenosine on the survival of glial cells exposed to chemical ischemia. J Neurosci Res 62: 539-546, 2000

12. Nakamizo T, Urushitani M, Inoue R, Shinohara A, Sawada H, Honda K, Kihara T, Akaike A, Shimohama S: Protection of motor neurons by estradiol. NeuroReport 11: 3493-3497, 2000

13. Kageyama T, Imura T, Matsuo A, Minato N, Shimohama S: Distribution of the 4F2 light chain, LAT1, in the mouse brain. NeuroReport 11: 3663-3666, 2000

14. Kim HT, Russell RL, Raine AK, Harris PLR, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G: Protein disulfide isomerase in Alzheimer disease. Antiox Redox Signal 2: 485-489, 2000

15. Shimohama S, Kihara T: Nicotinic receptor-mediated protection against beta amyloid neurotoxicity. Biol Psychiat in press

16. Kitamura Y, Ishida Y, Takata K, Kakimura J, Akaike A, Shimohama S, Taniguchi T: a-synuclein proteins is not scavenged in neuronal loss induced by kainic acid or focal ischemia. Brain Res in press

17. Kageyama T, Kawamata J, Shimohama S: Coexistence of two different type I repeats. Arch Neurol in press

18. Urushitani M, Nakamizo T, Inoue R, Sawada H, Kihara T, Honda K, Akaike A, Shimohama S: NMDA receptor-mediated mitochondrial Ca2+ overload in acute excitotoxic motor neurons death: a distinct mechanism from chronic neurotoxicity after Ca2+ influx. J Neurosci Res in press

19. Ibi M, Sawada H, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A: Protective effects of 1a,25 (OH)2D3 against neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology in press

20. Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Shibasaki H, Kume T, Akaike A: Alpha7 nicotinic receptor transduces signals to PI3 kinase to block Aβ-induced neurotoxicity. J Biol Chem in press

21. Kakimura J, Kitamura Y, Taniguchi T, Shimohama S, Gebicke-Haerter PJ: Bip/GRP78-induced production of cytokines and uptake of amyloid-b (1-42) peptide in microglia. Biochem Biophys Res Commun in press

22. Honda K, Shimohama S, Sawada H, Kihara T, Nakamizo T, Shibasaki H, Akaike A: Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons. J Neurosci Res in press

鈴木俊顕（東京都臨床医学総合研究所）

1. Matsuda N, Suzuki T, Tanaka K, Nakano A: Rma1, a novel RING-finger protein conserved from Arabidopsis to human, is a membrane-bound ubiquitin ligase. J Cell Sci in press

2. Nishimori S, Tanaka Y, Chiba T, Fujii M, Imamura T, Miyazono K, Ogasawara T, Kawaguchi H, Igarashi T, Fujita T, Tanaka K, Toyoshima H: Smad-mediated transcription is required for TGF-beta1-induced p57Kip2 proteolysis in osteoblastic cells. J Biol Chem in press

3. Tanaka K, Kawakami T, Tateishi K, Chiba T: Control of IkBa Proteolysis by the ubiquitin-proteasome pathway. Biochimie in press

4. Hattori N, Shimura H, Kubo S, Kitada T, Wang M, Asakawa S, Minoshima S, Shimizu N, Suzuki T, Tanaka K, Mizuno Y: Autosomal recessive juvenile parkinsonism: a key to understanding nigral degeneration in sporadic Parkinson's disease. Neuropathology 20: S85-90, 2000

5. Park KC, Choi EJ, Min SW, Chung SS, Kim H, Suzuki T, Tanaka K, Chung CH: Tissue specificity, functional characterization, and subcellular localization of rat ubiquitin-specific protease, UBP109, whose mRNA expression is developmentally regulated. Biochem J 349: 443-453, 2000

6. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshiam S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinson’s disease gene product, parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305, 2000

7. Osaka F, Saeki M, Aida N, Toh-e A, Katayama S, Kominami K, Toda T, Suzuki T, Chiba T, Tanaka K, Kato S: Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast. EMBO J 19: 1-10, 2000

8. Kim KI, Baek SH, Jeon YJ, Nishimori S, Suzuki T, Uchida S, Shimbara N, Saitoh H, Tanaka K, Chung CH: A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs. J Biol Chem 275: 14102-14106, 2000

9. Suzuki H, Chiba T, Suzuki T, Fujita T, Ikenoue T, Omata M, Furuichi K, Shikama H, Tanaka K: Homodimer of two F-box proteins βTrCP1 or βTrCP2 binds to IkBa for signal-dependent ubiquitination. J Biol Chem 275: 2877-2884, 2000

10. Takayanagi H, Ogasawara K, Hida S, Sato K, Takaoka A, Yokochi T, Murata S, Chiba T, Tanaka K, Oda H, Nakamura K, Taniguchi T: T cell-mediated regulation of osteoclastogenesis via novel signaling cross-talk between RANKL and IFN-g. Nature 408: 600-5, 2000

11. Suzuki H, Chiba T, Tanaka K: Identification and regulation of I-kBα-ubiquitin ligase complex. Recent Res Devel Immunol 2: 1-10, 2000

12. Kawahara H, Kasahara M, Nishiyama A, Ohsumi K, Goto T, Kishimoto T, Saeki Y, Yokosawa H, Shimbara N, Murata S, Chiba T, Suzuki K, Tanaka K: Developmentally regulated, alternative splicing of the Rpn10 gene generates multiple forms of 26S proteasomes. EMBO J 19: 4144-4153, 2000

高島明彦（理化学研究所・脳科学総合研究センター）

1. Song S, Ohba M, Saito Y, Honda T, Takashima A, Takahashi H: Proteolytic processing and degradation of human presenilin-1 expressed in yeast. Neurosci Lett 17: 65-68, 2000

2. Honda T, Nihonmatsu N, Yasutake K, Sato K, Tanaka S, Murayama O, Murayama M, Takashima A: Characterization of C-terminal fragment-specific antibody and localization of the full-length presenilin 1 in nuclear envelope. Neurosci Res 37: 101-11, 2000

高橋良輔（理化学研究所・脳科学総合研究センター）

1. Kawata A, Kato S, Shimizu T, Hayashi H, Hirai S, Misawa H, Takahashi R: Aberrant splicing of human Cu/Zn superoxide dismutase (SOD1) RNA transcripts. NeuroReport 11: 2649-2653, 2000

2. Imai Y, Soda M, Takahashi R: Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity. J Biol Chem 275: 35661-35664, 2000

遠山正弥（大阪大学・大学院医学系研究科）

1. Mori Y, Imaizumi K, Katayama T, Yoneda T, Tohyama M: Two cis-acting elements in the 3’ untranslated region of α-CaMKII regulate its dendritic targeting. Nat Neurosci 3: 1079-1084, 2000

2. Morihara T, Katayama T, Sato N, Yoneda T, Manabe T, Hitomi J, Abe H, Imaizumi K, Tohyama M: Absence of endoproteolysis but no effects on amyloid β production byalternative splicing forms of presenilin-1, which lack exon 8 and replace D257A. Mol Brain Res 85: 85-90, 2000

3. Morihara T, Katayama T, Sato N, Yoneda T, Manabe T, Hitomi J, Abe H, Imaizumi K, Tohyama M: Absence of endoproteolysis but no effects on amyloid β production byalternative splicing forms of presenilin-1, which lack exon 8 and replace D257A. Mol Brain Res 85: 85-90, 2000

4. Miyoshi K, Katayama T, Imaizumi K, Taniguchi M, Mori Y, Hitomi J, Yui D, Manabe T, Gomi F, Yoneda T, Tohyama M: Characterization of mouse Ire1α: cloning, mRNA localization in the brain and functional analysis in a neural cell line. Mol Brain Res. 85: 68-76, 2000

5. Tamatani M, Mitsuda N, Matsuzaki H, Okado H, Miyake S, Michael P, Vitec MP, Yamaguchi A, Tohyama M: A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: Roles of nuclear factor-kB and Bcl-2. J Neurochem 75: 683-693, 2000

6. Tanabe K, Tachibana T, Yamashita T, Che YH, Yoneda Y, Ochi T, Tohyama M, Yoshikawa H, Kiyama H: The small GTP-Binding protein TC10 promotes nerve elongation in neuronal cells, and its expression is induced during nerve regeneration in rats. J Neurosci 20: 4138-4144, 2000

7. Che YH, Tamatani M, Yamashita T, Gomi F, Ogawa S, Tohyama M: Changes in mRNA protein inhibitor of neuronal nitric oxide synthase following facial nerve transection. J Chem Neuroanat 17: 199-206, 2000

8. Bando Y, Ogawa S, Yamauchi A, Kuwabara K, Ozawa K, Tamatani M, Yanagi H, Tohyama M: The 150 kDa Oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in the protein transport of the MDCK cells. Am J Physiol Cell Physiol 278: 1172-1182, 2000

9. Che YH, Tamatani M, Tohyama M: Changes in mRNA for postsynaptic density 95 (PSD-95) and carboxy-terminal PDZ ligand of neuronal nitric oxide synthase following facial nerve transection. Mol Brain Res 76: 325-335, 2000

10. Gomi F, Imaizumi K, Yoneda T, Okita Y, Mori Y, Miyoshi K, Hitomi J, Fujikado T, Tano Y, Tohyama M: Molecular cloning of a novel leucine rich repeat (LRR) superfamily, Pal-1, which is specifically expressed in photoreceptor cells of retina. J Neurosci 20: 3206-3213, 2000

11. Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F,

Morihara T, Mori Y, Miyoshi K, Hitomi J, Yamada S, Okabe M, Tohyama M: Regulatory mechanisms of TRAF2 mediated signal transduction by Bcl10, MALT lymphoma associated protein. J Biol Chem 275: 11114-11120, 2000

中井彰（京都大学・再生医科学研究所）

1. Nakai A, Suzuki M, Tanabe M: Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1. EMBO J 19: 1545-1554, 2000

2. Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa S, Reed JC, Ishii S: p53 suppresses the c-myb-induced activation of heat shock transcription factor 3. J Biol Chem 275: 15578-15585, 2000

3. Nakai A, Ishikawa T: A nuclear localization signal is essential for stress-induced dimer-to-trimer transition of heat shock transcription factor 3. J Biol Chem 275: 34665-34671, 2000

西村正樹（滋賀医科大学・分子神経科学研究センター）

1. Yu G*, Nishimura M*, Arawaka S, Levitan D, Zhang L, Tandon A, Song YQ, Rogaeva E, Chen F, Kawarai T, Supala A, Levesque L, Yu H, Yang DS, Holmes E, Milman P, Liang Y, Zhang DM, Xu DH, Sato C, Rogaev E, Smith M, Janus C, Zhang Y, Aebersold R, Farrer L, Sorbi S, Bruni A, Fraser PE, St George-Hyslop P: Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and bAPP processing. Nature 407: 48-54, 2000 (* equally contributed)

2. Yu G, Chen F, Nishimura M, Steiner H, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Holmes E, Zhang DM, Milman P, Fraser PE, Haass C, St George-Hyslop P: Mutation of conserved aspartates affect maturation of both aspartate-mutant and endogenous presenilin 1 and presenilin 2 complexes. J Biol Chem 275: 27348-27353, 2000

3. Chen F, Yang DS, Petanceska S, Yang A, Tandon A, Yu G, Rozmahel R, Ghiso J, Nishimura M, Zhang DM, Kawarai T, Levesque G, Mills J, Levesque L, Song YQ, Rogaeva E, Westaway D, Mount H, Gandy S, St George-Hyslop P, Fraser PE: Carboxyl-terminal fragments of Alzheimer β-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1 deficient cells. J Biol Chem 275: 36794-36802, 2000                          

4. Zhang DM, Levitan D, Yu G, Nishimura M, Chen F, Tandon A, Kawarai T, Arawaka S, Supala A, Song YQ, Rogaeva E, Liang Y, Holmes E, Milman P, Sato C, Zhang L, St George-Hyslop P: Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ42 secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans. NeuroReport 11: 3227-3230, 2000

5. Van Gassen G, De Jonghe C, Nishimura M, Yu G, Kuhn S, St George-Hyslop P, Van Broeckhoven C: Evidence that the β-catenin nuclear translocation assay allows for measuring presenilin 1 dysfunction. Mol Med 6: 570-580, 2000

貫名信行（理化学研究所・脳科学総合研究センター）

1. Wang G-H, Sawai N, Kotliarova S, Kanazawa I, Nukina N: Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. Hum Mol Genet 9: 1795-1803, 2000

2. Jana N-R, Tanaka M, Wang G-H, Nukina N: Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity. Hum Mol Genet 9: 2009-2018, 2000

3. Nagao Y, Ishiguro H, Nukina N: DMSO and glycerol reduce bacterial death induced by expression of truncated N-terminal huntingtin with expanded polyglutamine tracts. Biochim Biophys Acta 1502: 247-256, 2000

4. Iwata A, Miura S, Kanazawa I, Sawada M, Nukina N: a–synuclein forms a complex with transcription factor Elk-1. J Neurochem 77: 239-252, 2001

5. Jana N-R, Zemskov E-A, Wang G-H, Nukina N: Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum Mol Genet in press

長谷川一子（北里大学・医学部）

1. Hasegawa K, Sakai F, Kowa H: The phenomenon of nocturnal dystonia in Parkinoson's disease. Eur Neurol 8(suppl 1): 1-5, 2001

2. Hasegawa K, Funnayama M, Matsuura N, Sakai F, Kowa H, Obata F: Analysis of a-synuclein, parkin, tau, and UCH-L1 In a Japanese family of autosomal dominant parkinsonism. Eur Neurol in press

服部信孝（順天堂大学・医学部）

1. Kobayashi T, Wang M, Hattori N, Matsumine H, Kondo T, Mizuno Y: Exonic deletion mutations of the parkin gene among sporadic patients with Parkinson’s disease. Parkinsonism Related Disord 6:129-131, 2000.

2. Zhang J, Hattori N, Giladi N, Mizuno Y: Failure to find mutations in ubiquitin carboxy-terminal hydrolase L1 gene in familial Parkinson’s disease. Parkinsonism Related Disord 6: 199-200, 2000.

3. Zhang J, Hattori N, Leroy E, Morris HR, Kubo S, Kobayashi T, Wood NW, Polymeropoulos MH, Mizuno Y: Association between a polymorphism of ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) Gene and Sporadic Parkinson’s Disease. Parkinsonism Related Disord 6: 199-200, 2000.

4. Shimura H, Hattori N, Kubo S, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial parkinson’s disease gene product, Parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305, 2000.

5. Urabe T, Yamasaki Y, Hattori N, Yoshikawa M, Uchida K, Mizuno Y: Accumulation of 4-hydroxynonenal-modified proetins in hyppocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil braiin. Neuroscience 14: 241-250, 2000.

6. Takanashi M, Mochizuki H, Yokomizo K, Hattori N, Mori H, Yamamura Y, Mizuno Y: Iron accumulation in the substantia nigra of autosomal recessive juvenile parkinsonism (ARJP). Parkinsonism Related Disord in press

船越洋（大阪大学・大学院医学系研究科）

1. Nakamura K, Funakoshi H, Miyamoto K, Tokunaga F, Nakamura T: Molecular cloning and functional characterization of a human scavenger receptor with C-type lectin (SRCL), a novel member of a scavenger receptor family. Biochem Biophys Res Commun 280: 1028-1035, 2001    

2. Sun W, Funakoshi H, Matsumoto K, Nakamura T: A sensitive quantification method for evaluating the level of hepatocyte growth factor and c-met/HGF receptor mRNAs in the nervous system using competitive RT-PCR. Brain Res Protocol 5: 190-197, 2000

堀江秀典（横浜市立大学・医学部）

1. Inagaki Y, Sohma Y, Horie H, Nozawa R, Kadoya T: Oxidized Galectin-1 promotes axonal regeneration in peripheral nerves but does not possess lectin properties. Eur J Biochem 267: 2955-2964, 2000

2. Horie H, Kadoya T: Identification of oxidized galectin-1 as an initial re pair regulatory factor after axotomy in peripheral nerves. Neurosci Res 38: 131-137, 2000

3. Shuto T, Horie H, Hikawa N, Sango K, Tokashiki A, Murata H, Yamamoto I, I shikawa Y: IL-6 upregulates CNTF mRNA expression and enhances neurite regene ration. NeuroReport in press

松井秀樹（岡山大学・医学部）

1. Tomizawa K, Cai X-H, Moriwaki A, Matsushita M, Matsui H: Involvement of cyclin-dependent kinase 5/p35nck5a in the synaptic recorganization of rat hippocampus during kindling progression. Jpn J Physiol 50: 525-532, 2000

2. Miyamoto O, Nakamura T, Yamagami S, Negi T, Tokuda M, Matsui H, Itano T: Depression of long term potentiation in gerbil hippocampus following postischemic hypothermia: Brain Res 873: 168-172, 2000

3. Feng J, Yan Z, Ferreira A, Tomizawa K, Liauw J A, Zhuo M, Allen PB, Ouimet CC, Greengard P: Spinophilin regulates the formation and function of dendritic spines. Proc Natl Acad Sci USA 97: 9287-9292, 2000

4. Matsui H, Tomizawa K, Matsushita M, Moriwaki A: Role of calcineurin in neuronal plasticity: J Clin Exp Med 193: 945-949, 2000

水澤英洋（東京医科歯科大学・大学院医歯学総合研究所）

1. Mitoma H, Song S-Y, Ishida K, Yamakuni T, Kobayashi T, Mizusawa H: Presynapic impairment of cerebellar inhibitory synapses by an autoantibody to glutamate decarboxylase. J Neurol Sci 175: 40-44, 2000

2. Toru S, Murakoshi T, Ishikawa K, Saegusa H, Fujigasaki H, Uchihara T, Nagayama S, Osanai M, Mizusawa H, Tanabe T: Spinocerebellar ataxia type 6 mutation alters p-type calcium channel function. J Biol Chem 275: 10893-10898, 2000

3. Yang Q, Hashizume Y, Yoshida M, Goto Y, Mitsuma N, Ishikawa K, Mizusawa H: Morphological purkinje cell changes in spinocerebellar type6. Acta Neuropathol 100: 371-376, 2000

4. Yokota T, Uchihara T, Kumagai J, Shiojiri T, Pang J J, Arai M, Arai H, Hayashi M, Kiyosawa M, Okeda R, Mizusawa H: Postmortem study of ataxia with retinitis pigmentosa by mutation of the a-tocopherol transfer protein. J Neurol Neurosurg Psychiat 68: 521-525, 2000

5. Nagaoka U, Takashima M, Shikawa K, Yoshizawa K, Yoshizawa T, Ishikawa M, Yamawaki T, Shoji S, Mizusawa H: A gene on SCA4 locus causes dominantly inherited pure cerebellar ataxia.  Neurology 54: 1971-1975, 2000

6. Fujigasaki H, Uchihara T, Koyano S, Iwabuchi K, Yagishita S, Makifuchi T, Nakamura A, Ishida K, Toru S, Hirai S, Ishikawa K, Tanabe T, Mizusawa H: Ataxin-3 is translocated into the nucleus for the formation of intranuclear inclusions in normal and Machado-Joseph disease brains. Exp Neurol 165: 248-256, 2000

7. Mizusawa H, Ishii T, Bannai S : Peroxiredoxin I（macrophage 23 kDa stress protein）is highly and widely expressed in the rat nervous system. Neurosci Lett 283: 57-60, 2000

宮田雄平（日本医科大学・医学部）

1. Ui-Tei K, Nagano M, Sato S, Miyata Y: Calmodulin-dependent and -independent apoptosis in cells of a Drosophila neuronal cell line. Apoptosis 5: 133-140, 2000

2. Ui-Tei K, Zenno S, Miyata Y, Saigo K: Sensitive assay of RNA interference in Drosophila and Chinese hamster cultured cells using firefly luciferase gene as target. FEBS Lett 479: 79-82, 2000

3. Hamada T, Ui-Tei K, Miyata Y: A novel gene derived from developing spinal cords, SCDGF, is a unique member of the PDGF/VEGF family. FEBS Lett 475: 97-102, 2000

4. Hamada T, Ui-Tei K, Imaki J, Miyata Y: Molecular cloning of SCDGF-B, a novel growth factor homologous to SCDGF/PDGF-C/ fallotein. Biochem Biophys Res Commun 280: 733-737, 2001

5. Nagano M, Ui-Tei K, Suzuki H, Piao ZF, Miyata Y: CDK inhibitors suppress apoptosis induced by chemicals and by excessive expression of a cell death gene, reaper, in Drosophila cells. Apoptosis in press

山下拓史（広島大学・医学部）

1. Nakamura T, Yamashita H, Takahashi T, Nakamura S: Activated Fyn phosphorylates alpha-synuclein at tyrosine residue 125. Biochem Biophys Res Commun 280: 1085-1092, 2000

吉田裕樹（九州大学・生体防御医学研究所）

1. Chen QJ, Yoshida H, Takimoto H, Ninomiya T, Ohtsu M, Kimura G, Nomoto K: Ineffective control of murine cytomegalovirus by IE1-specific cytotoxic T lymphocytes during protracted infection in the lung. Arch Virol 145: 1291-304, 2000

2. Haraguchi M, Torii S, Matsuzawa S, Xie Z, Kitada S, Krajewski S, Yoshida H, Mak TW, Reed JC: Apoptotic Protease Activating Factor 1 (Apaf-1)-independent Cell Death Suppression by Bcl-2. J Exp Med 191: 1709-1720, 2000

3. Hossain MS, Takimoto H, Ninomiya T, Yoshida H, Kishihara K, Matsuzaki G, Kimura G, Nomoto K: Characterization of CD4- CD8- CD3+ T-cell receptor-alphabeta+ T cells in murine cytomegalovirus infection. Immunology 101: 19-29, 2000

4. Yada S, Nukina H, Kishihara K, Takamura N, Yoshida H, Inagaki-Ohara K, Nomoto K, Lin T: IL-7 prevents both caspase dependent and independent pathways that lead to the spontaneous apoptosis of i-IEL. Cell Immunol in press


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