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A03班

井原康夫（東京大学・大学院医学系研究科）

1. Misonou H, Morishima-Kawashima M, Ihara Y: Oxidative stress induces intracellular accumulation of amyloid β-protein (A β) in human neuroblastoma cells. Biochemistry 39: 6951-6959, 2000

2. Saito Y, Kawai M, Inoue K, Sasaki R, Arai H, Nanba E, Kuzuhara S, Ihara Y, Kanazawa I, Murayama S:Widespread expression of a-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course. J Neurol Sci 177: 48-59, 2000

3. Gu Y, Hamajima N, Ihara Y: Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518 and Ser-522. Biochemistry 39: 4267-4275, 2000

4. Gu Y, Ihara Y: Evidence that collapsin response mediator protein-2 (CRMP-2) is involved in the dynamics of microtubules. J Biol Chem 275: 17917-17920, 2000

5. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Ito M, Oyama F, Ando S, Ihara Y: Mutant-presenilin 2-transgenic mice: A large increase in the levels of A β42 is presumably associated with the low-density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem 275: 27901-27908, 2000

6. Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, lhara Y: Effect of apolipoprotein E allele ε4 on the initial phase of amyloid β-protein accumulation in the human brain. Am J Pathol 157: 2093-2099, 2000

7. Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y: Molecular analysis of mutant and wild-type tau deposited in the brain affected by FTDP-17 R406W mutation. Am J Pathol 158: 373-379, 2001

8. Yamazaki T, Chang TY, Haass C, Ihara Y: Accumulation and aggregation of amyloid β-protein in late endosomes of Niemann-Pick Type C cells. J Biol Chem 276: 4454-4460, 2001

田平武（国立精神・神経センター神経研究所）

1. Tanahashi H, Tabira T: Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein. Hum Mol Genet 9: 2281-2289, 2000

2. Sawamura N, Morishima-Kawashima M, Waki H, Kobayashi K, Kuramochi T, Frosch MP, Ding K, Ito M, Kim TW, Tanzi RE, Oyama F, Tabira T, Ando S, Ihara Y: Mutant presenilin 2 transgenic mice. A large increase in the levels of A β42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin. J Biol Chem 275: 27901-27908, 2000

3. Kodama K, Okada S, Iseki E, Kowalska A, Tabira T, Hosoi N, Yamanouchi N, Noda S, Komatsu N, Nakazato M, Kumakiri C, Yazaki M, Sato T: Familial frontotemporal dementia with a P301L tau mutation in Japan. J Neurol Sci 176: 57-64, 2000

4. Arima K, Kowalska A, Hasegawa M, Mukoyama M, Watanabe R, Kawai M, Takahashi K, Goedert M, Iwatsubo T, Tabira T, Sunohara N: Two brothers of frontotemporal dementia and parkinsonism with an N279K mutation of the tau gene. Neurology 54: 1787-1795, 2000

5. Shirotani K, Takahashi K, Araki W, Tabira T: Mutational analysis of intrinsic regions of presenilin 2 which determine its endoproteolytic cleavage and pathological function. J Biol Chem 275: 3681-3686, 2000

6. Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Chui DH, Tabira T: Chronic stress induces impairment of spatial working memory because of prefrontal dopaminergic dysfunction. J Neurosci 20:1568-1574, 2000>

柳澤勝彦（国立長寿医療研究センター）

1. Hayashi H, Mizuno T, Michikawa M, Haass C, Yanagisawa K:Amyloid precursor protein in unique cholesterol-rich microdomains different from caveolae-like domains. Biochim Biophys Acta 1483: 81-90, 2000

2. Michikawa M, Fan Q-W, Isobe I, Yanagisawa K: Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from cultured astrocytes and neurons via interaction with cell surface heparan sulfate proteoglycans. J Neurochem 74: 1008-1016, 2000

3. Fukuyama R, Mizuno T, Mizuno T, Mori S, Nakajima K, Fushiki S, Yanagisawa K: Age-dependent change in the levels of A β40 and A β42 in cerebrospinal fluid from control subjects, and a decrease in the ratio of A β42 to A β40 level in cerebrospinal fluid from Alzheimer’s disease patients. Eur Neurol 43: 155-160, 2000

4. Fukuyama R, Mizuno T, Mori S, Yanagisawa K, Nakajima K, Fushiki S: Age-dependent decline in the level of apolipoprotein E in cerebrospinal fluid from control subjects, and its increase in cerebrospinal fluid from Alzheimer’s disease patients. Eur Neurol 43: 161-169, 2000

5. Isobe I, Yanagisawa K, Michikawa M: A possible model of senile plaques using synthetic amyloid β-protein and rat glial culture. Exp Neurol 162: 51-60, 2000

6. Sudoh S, Hua G, Kawamura Y, Maruyama K, Komano H, Yanagisawa K: Intracellular site of A β42-cleavage which is enhanced by presenilin 1 mutations. Eur J Biochem 267: 2036-2045, 2000

7. Fan Q-W, Yu W, Senda T, Yanagisawa K, Michikawa M: Cholesterol-dependent modulation of tau phosphorylation in cultured neurons. J Neurochem 76: 391-400, 2001

8. Isobe I, Yanagisawa K, Michikawa M: 3-(4,5-dimethylthiazol-2-yl)-2,5diphenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes. J Neurochem in press

9. Sawamura N, Gong J-S, Garver WS, Heidenreich RA, Ninomiya H, Ohno K, Yanagisawa K, Michikawa M: Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice. J Biol Chem in press

西道隆臣（理化学研究所・脳科学総合研究センター）

1. Iwata N, Tsubuki S, Takaki Y, Watanabe K, Sekiguchi M, Hosoki E, Kawashima-Morishima M, Lee H-J, Hama E, Sekine-Aizawa Y, Saido TC: Identification of the major A b1-42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition. Nat Med 6: 143-151, 2000

2. Shimokata H, Yamada Y, Nakagawa M, Okubo R, Saido TC, Funakoshi A, Miyasaka K, Ohota S, Tsujimoto G, Tanaka M, Ando F, Niino N: Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). J Epidermiol 10(Suppl): S46-55, 2000

3. Russo C, Schettini G, Saido TC, Hulette C, Lippa C, Lannfelt L, Ghetti B, Gambetti P, Tabaton M, Teller JK: Preferential deposition of truncated amyloid- β peptides in brain of presenilin 1 gene mutation carriers. Nature 405: 531-532, 2000

4. Nakagawa Y, Reed L, Nakamura M, McIntosh TK, Smith DH, Saatman KE, Raghupathi R, Clemens J, Saido TC, Lee VME, Trojanowski JQ: Brain trauma in aged transgenic mice induces regression of established A β deposit. Exp Neurol 163: 244-252, 2000

5. Lankiewicz S, Luetjens CM, Bui NT, Krohn AJ, Poppe M, Cole GC, Nicholson DW, Saido TC, Prehn HM: Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J Biol Chem 275: 17064-17071, 2000

6. Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DMA, Hyman BT, Iwatsubo T: Age-related A β deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and β amyloid precursor protein is not associated with global neuronal loss. Am J Pathol 157: 331-339, 2000

7. Hiwasa T, Arase Y, Kikuno K, Hasegawa R, Sugaya S, Kita K, Saido T, Yamamori H, Maki M, Suzuki N: Increase in ultraviolet sensitivity by overexpression of calpastatin in ultraviolet-resistant UVr-1 cells derived from ultraviolet-sensitive human RSa cells. Cell Death Differ 7: 531-537, 2000

8. Iwata N, Tsubuki S, Hama E, Takaki Y, Shirotani K, Saido TC: Clearance of amyloid β-peptide from brain: transport or metabolism? Nat Med 6: 718-719, 2000

9. Harigaya Y, Saido TC, Eckman CB, Prada C-M, Shoji M, Younkin S: Amyloid β protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochem Biophys Res Commun 276: 422-427, 2000

10. Lee H-J, Tomioka M, Takaki Y, Masumoto H, Saido TC: Molecular cloning and expression of aminopeptiase A isoforms from rat hippocampus. Biochim Biophys Acta 1493: 273-278, 2000

11. Takaki Y, Iwata N, Tsubuki S, Taniguchi S, Toyoshima S, Lu B, Gerard NP, Gerard C, Lee H-J, Shirotani K, Saido TC: Biochemical Identification of the neutral endopeptidase family member responsible for the catabolism of amyloid b peptide in brain. J Biochem (Tokyo) 128: 897-902, 2000

12. Kawarabayashi T, Younkin LH, Saido TC, Shoji M, K Hsiao A, Younkin SG: Age-dependent changes in brain, cerebrospinal fluid, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21: 372-381, 2001

13. Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S: Metabolism of amyloid precursor protein in COS cells transfected with a β-secretase candidate. Cytotechnology 33: 213-219, 2000

14. Kitagaki H, Tomioka S, Yoshizawa T, Sorimachi H, Saido TC, Ishiura S, Suzuki K: Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain. Biosci Biotechnol Biochem 64: 689-695, 2000

15. Shoji M, Kawarabayashi T, Sato M, Sasaki A, Saido TC, Matsubara E, Yomidokoro Y, Kanai M, Shizuka M, Ishiguro K, Ikeda M, Harigaya Y, Okamoto K, Hirai S: Age-related amyloid β protein accumulation induces cellular death and macrophage activation in transgenic mice. J Pathol 191: 93-101, 2000

16. Yamaguchi A, Yamamoto N, Akamatsu N, Saido TC, Kaneda M, Umeda M, Tanoue K: PS-liposome and ox-LDL bind to different sites of the immunodominant domain (#155-183) of CD 36: a new study with GS95, a new anti-CD36 monoclonal antibody. Thromb Res 97: 317-326, 2000

17. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: inhibition of μ-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by μ-calpain. Int J Mol Med 5: 269-273, 2000

18. Taniguchi S, Fujita Y, Takahashi H, Hayashi S, Kakita A, Murayama S, Saido TC, Hisanaga S, Iwatsubo T, Hasegawa M: Degradation of p35 to p25 in postmortem human and rat brains. FEBS Lett 489: 46-50, 2001

19. Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido TC: Matrix metalloproteinase (MMP) system in brain: Identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci in press

20. Bialkowska K, Kulkarni S, Du X, Goll DE, Saido TC, Fox JEB: Evidence that ß3 integrin-induced Rac activation involves the calpain-dependent formation of integrin clusters that are distinct from the focal complexes and focal adhesions that form as Rac and RhoA become active. J Cell Biol 151: 685-695, 2000

新井哲明（東京都精神医学総合研究所）

1. Ikeda K, Akiyama H, Arai T, Kondo H, Haga C, Tsuchiya K, Yamada S, Murayama S, Hori A: Neurons containing Alz-50-immunoreactive granules around the cerebral infarction: evidence for the lysosomal degradation of altered tau in human brain? Neurosci Lett 284: 187-189, 2000

2. Ikeda K, Akiyama H, Arai T, Matsushita M, Tsuchiya K, Miyazaki H: Clinical aspects of argyrophilic grain disease. Clin Neuropathol 19: 278-284, 2000

3. Arai T, Ikeda K, Akiyama H, Shikamoto Y, Tsuchiya K, Yagishita S, Beach T, Rogers J, Schwab C, McGeer PL: Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick’s disease, corticobasal degeneration and progressive supranuclear palsy. Acta Neuropathol 101: 167-173, 2001

4. Arai T, Ikeda K, Akiyama H, Tsuchiya K, Yagishita S, Takamatsu J: Intracellular processing of aggregated tau differs between corticobasal degeneration and progressive supranuclear palsy. NeuroReport in press

有賀純（理化学研究所・脳科学総合研究センター）

1. Kitaguchi T, Nakata K, Nagai T, Aruga J, Mikoshiba K: Xenopus Polycomblike 2 (XPcl2) controls anterior to posterior patterning of the neural tissue. Dev Genes Evol in press

2. Koyabu Y, Nakata K, Mizugishi K, Aruga J, Mikoshiba K: Physical and functional interaction between Zic and Gli proteins. J Biol Chem in press

3. Mizugishi K, Aruga J, Nakata K, Mikoshiba K: Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins. J Biol Chem 276: 2180-2188, 2001

4. Salero E, Perez-Sen R, Aruga J, Gimenez C, Zafra F: Transcription factors Zic1 and Zic2 bind and transactivate the apolipoprotein E gene promoter. J Biol Chem 276: 1881-1888, 2001

5. Nakata K, Koyabu Y, Aruga J, Mikoshiba K: A novel member of Xenopus Zic family, Zic5, specifically mediates neural crest development. Mech Dev 99: 83-91, 2000

6. Kitaguchi T, Nagai T, Nakata K, Aruga J, Mikoshiba K: Zic3 is involved in the left-right asymmetry as a left signal mediator in Xenopus embryo. Development 127: 4787-4795, 2000

7. Aruga J, Shimoda K, Mikoshiba K: A 5' segment of the mouse Zic1 gene contains a region specific enhancer for dorsal hindbrain and spinal cord. Mol Brain Res 78: 15-25, 2000

8. Nagai T, Aruga J, Minowa O, Sugimoto T, Ohno Y, Noda T, Mikoshiba K: Zic2 regulates the kinetics of neurulation. Proc Natl Acad Sci USA 97: 1618-1623, 2000

石浦章一（東京大学・大学院総合文化研究科）

1. Usuki F, Takahashi N, Sasagawa N, Ishiura S: Differential signaling pathways following oxidative stress in mutant myotonin protein kinase cDNA transfected C2C12 cell lines. Biochem Biophys Res Commun 267: 739-743, 2000

2. Hata S, Sato T, Sorimachi H, Ishiura S, Suzuki K: A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors. J Virol Method 84: 117-126, 2000

3. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: inhibition of μ-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, µ-calpain. Int J Mol Med 5: 269-273, 2000

4. Koike H, Kouchi Z, Kinouchi T, Maeda T, Sorimachi H, Saido TC, Maruyama K, Okuyama A, Suzuki K, Ishiura S: Metabolism of amyloid precursor protein in COS cells transfected with a a–secretase candidate. Cytotechnology 33: 213-219, 2000

5. Tagawa K, Taya C, Hayashi Y, Nakagawa M, Ono Y, Fukuda R, Karasuyama H, Toyama-Sorimachi N, Katsui Y, Hata S, Ishiura S, Nonaka I, Seyama Y, Arahata K, Yonekawa H, Sorimachi H, Suzuki K: Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 slkeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A. Hum Mol Genet 9: 1393-1402, 2000

6. Kitagaki H, Tomioka S, Yoshizawa T, Sorimachi H, Saido TC, Ishiura S, Suzuki K: Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain. Biosci Biotechnol Biochem 64: 689-695, 2000

7. Takahashi N, Sasagawa N, Suzuki K, Ishiura,S: The CUG-binding protein (CUG-BP) binds specifically to UG dinucleotide repeats in a yeast three-hybrid system. Biochem Biophys Res Commun 277: 518-523, 2000

8. Sakaki M, Takahashi N, Sasagawa N, Arahata K, Ishiura S: Interaction between emerin and nuclear lamins. J Biochem (Tokyo) 129: 321-327, 2001

一瀬宏（藤田保健衛生大学・総合医科学研究所）

1. Mogi M, Togari A, Kondo T, Mizuno Y, Komure O, Kuno S, Ichinose H, Nagatsu T: Caspase activities and tumor necrosis factor receptor R1 (p55) level are elevated in the substantia nigra from Parkinsonian brain. J Neural Transm 107: 335-341, 2000

2. Hibiya M, Ichinose H, Ozaki N, Fujita K, Nishimoto T, Yoshikawa T, Asano Y, Nagatsu T: Normal values and age-dependent changes in GTP cyclohydrolase I activity in stimulated mononuclear blood cells measured by high-performance liquid chromotography. J Chromatogr 740: 35-42, 2000

3. Kaneko S, Hikida T, Watanabe D, Ichinose H, Nagatsu T, Kreitman RJ, Pastan I, Nakanishi S: Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function. Science 289: 633-637, 2000

4. Shen Y, Muramatsu S-i, Ikeguchi K, Fujimoto K-i, Fan D-S, Ogawa M, Mizukami H, Urabe M, Kume A, Nagatsu I, Urano F, Suzuki T, Ichinose H, Nagatsu T, Monahan J, Nakano I, Ozawa K: Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson's disease. Hum Gene Ther 11: 1509-1519, 2000

5. Mogi M, Togari A, Tanaka K, Ogawa N, Ichinose H, Nagatsu T: Increase in level of tumor necrosis factor-a in 6-hydroxydopamine-lesioned striatum in rats is suppressed by immunosuppressant FK506. Neurosci Lett 289: 165-168, 2000

6. Tazawa M, Ohtsuki M, Sumi-Ichinose C, Shiraishi H, Kuroda R, Hagino Y, Nakashima S, Nozawa Y, Ichinose H, Nagatsu T, Nomura T: GTP cyclohydrolase I from Tetrahymena pyriformis: cloning of cDNA and expression. Comp Biochem Physiol B 127: 65-73, 2000

7. Ichinose H, Inagaki H, Suzuki T, Ohye T, Nagatsu T: Molecular mechanisms of hereditary progressive dystonia with marked diurnal fluctuation, Segawa's disease. Brain Dev 22: S107-S110, 2000

井出千束（京都大学・大学院医学研究科）

1. Ide C, Kitada M, Chakrabortty S, Taketomi M, Matsumoto N, Kikukawa S, Mizoguchi A, Kawaguchi S, Endo K, Suzuki Y: Grafting of choroid plexus ependymal cells promotes the growth of regenerating axons in the dorsal funiculus of rat spinal cord: A preliminary report. Exp Neurol in press

2. Chakrabortty S, Kitada M, Matsumoto N, Taketomi M, Kimura K, Ide C: Choroid plexus ependymal cells enhance the neurite outgrowth from dorsal root ganglion neurons in vitro. J Neurocytol in press

3. Mligiliche N, Kitada M, Ide C: Grafting of detergent-denatured skeletal muscles provides effective conduits for extension of regenerating axons in the rat sciatic nerve. Arch Histol Cytol in press

4. Shirasu M, Kimura K, Kataoka M, Takahashi M, Okajima S, Kawaguchi S, Hirasawa Y, Ide C, Mizoguchi A: VAMP-2 promotes neurite elongation and SNAP-25A increases neurite sprouting in PC12 cells. Neurosci Res 37: 265-275, 2000

5. Nishida A, Takahashi M, Tanibara H, Nakano I, Takahashi J, Mizoguchi A, Ide C, Honda Y: Incorporation and differentiation of neural stem cells transplanted in injured adult rat retina. Invest. Ophthalmol Vis Sci 41: 4268-4274, 2000

6. Asai K, Fujimoto K, Harazaki M, Kusunoki T, Korematsu S, Ide C, Ra C, Hosoi S: Distinct aggregation of β- and γ-chains of the high-affinity IgE receptor on cross-linking. J Histochem Cytochem 48: 1705-1715, 2000

7. Okajima S, Shirasu M, Hirasawa Y, Ide C: Ultrastructural characteristics and synaptophysin immunohistochemistry of regenerating nerve growth cones following traumatic injury to rat peripheral nerve. J Reconstruct Microsurg 16: 637-642, 2000

8. Kataoka K, Suzuki Y, Kitada M, Ohnishi K, Suzuki K, Tanihara M, Ide C, Endo K, Nishimura Y: Alginate, a bioresorbable material derived from brown seaweed, enhances elongation of amputatd axons of spinal cord in infant rats. J Biomed Mater Res 54: 373-384, 2000

9. Yoshida Y, Morita K, Mizoguchi A, Ide C, Miyachi Y: Altered expression of occludin and tight junction formation in psoriasis. Arch Dermatol Res in press

伊藤英晃（秋田大学・医学部）

1. Kumagai J, Fukuda J, Kodama H, Murata M, Kawamura K, Itoh H, Tanaka T: Germ cell-specific heat shock protein 105 binds to p53 in a temperature-sensitive manner in rat testis. Eur J Biochem 267: 3073-3078, 2000

2. Takahashi S, Wakui H, Gustafsson JA, Zilliacus J, Itoh H: Functional interaction of the immunosuppressant mizoribine with the 14-3-3 protein. Biochem Biophys Res Commun 274: 87-92, 2000

3. Okubo A, Kinouchi H, Owada Y, Kunizuka H, Itoh H, Izaki K, Kondo H, Tashima Y, Yoshimoto T, Mizoi K: Simultaneous induction of mitochondrial heat shock protein mRNAs in rat forebrain ischemia. Mol Brain Res 84: 127-134, 2000

4. Kawamura K, Fukuda J, Itoh H, Ito K, Kodama H, Kumagai J, Kumagai A, Tanaka T: Chaperonin 10 in the rat oocytes and early embryos: its expression and activity for early pregnancy factor. Am J Reprod Immunol 44: 242-248, 2000

5. Iabuchi A, Otaka M, Otani S, Jin M, Okuyama A, Itoh S, Sasahara H, Odashima M, Ivan P, Itoh H, Tashima Y, Masamune O, Watanabe S: Specific preinduction of 60-kDa heat shock protein (chaperonin homolog) by TRH does not protect clonic mucosa against acetic acid-induced lesion in rats. Digest Dis Sci 45: 1480-1489, 2000

6. Motoyama S, Saito S, Alojado ME, Itoh H, Kitamura M, Suzuki H, Saito R, Momiyama H, Nakae H, Ogawa J, Inaba H: Hydrogen peroxide induces midzonal heat shock protein 72 and apoptosis in sinusoidal endothelial cells of hypoxic rat liver. Crit Care Med 28: 1509-1514, 2000

岩井一宏（京都大学・大学院生命科学研究科）

1. Sadot E, Simcha I, Iwai K, Ciechanover A, Geiger B, Ben-Ze'ev A: Differential interaction of plakoglobin and ß-catenin with the ubiquitin-proteasome system. Oncogene 19: 1992-2001, 2000

2. Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israel A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A: SCF ^b^-TrCP ubiquitin ligase-mediated processing of NF-kB p105 requires phosphorylation of its C-terminus by IkB kinase. EMBO J 19: 2580-2591, 2000

3. Shimura H, Hattori N, Kubo S-I, Mizuno Y, Asakawa S, Minoshima S, Shimizu N, Iwai K, Chiba T, Tanaka K, Suzuki T: Familial Parkinson's disease gene product, Parkin, is a ubiquitin-protein ligase. Nat Genet 25: 302-305, 2000

4. Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW: Activation of HIF1a ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA 97: 10430-10435, 2000

5. LaVaute T, Smith S, Cooperman S, Iwai K, Land W, Meyron-Holtz E, Drake SK, Miller G, Abu-Asab M, Tsokos M, Switzer IIIR, Grinberg A, Love P, Tresser N, Rouault T: Targeted deletion of iron regulatory protein 2 causes iron overload and neurodegenerative disease in mice. Nat Genet 27: 209-214, 2001

岡本卓（理化学研究所・脳科学総合研究センター）

1. Flores AI, Mallon B, Matsui T, Ogawa W, Rosenzweig A, Okamoto T, Macklin WB: Akt mediated survival of oligodendrocytes by neuregulins. J Neurosci 20: 7622-7630, 2000

小澤一史（京都府立医科大学）

1. Xie C-X, Ozawa H, Yang Y, Kawata M: Immunohistochemical study of nucleoporin p62 in the hippocampus and hypothalamus of the rat brain. NeuroReport 11: 2965-2967, 2000

2. Y, Ozawa H, Nishi M, Yuri K, Kawata M: Postnatal development of NADPH-diaphorase activity in the rat: The role of nitric oxide in the ontogeny of arginine vasopressin and oxytocin. Endocr J 47: 601-613, 2000

3. Kikuchi N, Urabe M, Tanaka K, Hosoda T, Tatsumi H, Kariya K, Honjo H, Ozawa H, Kawata M: Effects of estrogen on basal forebrain cholinergic neurons of the rat. Adv Obst Gynecol 52: 367-371, 2000

加藤兼房（愛知県心身障害者コロニー・発達障害研究所）

1. Kozawa O, Tanabe K, Matsuno H, Niwa M, Yamamoto T, Akamatsu S, Kato K, Dohi S, Uematsu T: Pentobarbital, but not propofol, suppresses vasopressin-stimulated heat shock protein 27 induction in aortic smooth muscle cells. Anesthesiology 92: 1807-1813, 2000

2. Kim HC, Jhoo WK, Kim WK, Suh JH, Shin EJ, Kato K, Ho Ko K: An immunocytochemical study of mitochondrial manganese-superoxide dismutase in the rat hippocampus after kainate administration. Neurosci Lett 281: 65-68, 2000

3. Ito T, Kozawa O, Tanabe K, Niwa M, Matsuno H, Sakai N, Ito H, Kato K, Uematsu T: p38 MAP kinase is required for vasopressin-stimulated HSP27 induction in aortic smooth muscle cells. Hypertension 35: 673-678, 2000

4. Kim H, Bing G, Jhoo W, Ko KH, Kim WK, Suh JH, Kim SJ, Kato K, Hong JS: Changes of hippocampal Cu/Zn-superoxide dismutase after kainate treatment in the rat.

Brain Res 853: 215-226, 2000

5. Katoh-Semba R, Takeuchi IK, Semba R, Kato K: Neurotrophin-3 controls proliferation of granular precursors as well as survival of mature granule neurons in the developing rat cerebellum. J Neurochem 74: 1923-1930, 2000

6. Morrow G, Inaguma Y, Kato K, Tanguay RM: The small heat shock protein Hsp22 of Drosophila melanogaster is a mitochondrial protein displaying oligomeric organization. J Biol Chem 275:31204-31210, 2000

7. Bidmon HJ, Oermann E, Schiene K, Schmitt M, Kato K, Asayama K, Witte OW, Zilles K: Unilateral upregulation of cyclooxygenase-2 following cerebral, cortical photothrombosis in the rat: suppression by MK-801 and co-distribution with enzymes involved in the oxidative stress cascade. J Chem Neuroanat 20: 163-176, 2000

8. Kato K, Inaguma Y, Ito H, Iida K, Iwamoto I, Kamei K, Ochi N, Ohta H, Kishikawa M: Ser-59 is the major phosphorylation site in alphaB-crystallin accumulated in the brains of patients with Alexander's disease. J Neurochem 76: 730-736, 2001

9. Ito H, Kamei K, Iwamoto I, Inaguma Y, Nohara D, Kato K: Phosphorylation-induced change of the oligomerization state of alpha B-crystallin. J Biol Chem 276: 5346-5352, 2001

10. Ueda H, Morishita R, Yamauchi J, Itoh H, Kato K, Asano T: Regulation of Rac and Cdc42 pathways by Gi during lysophosphatidic acid-induced cell spreading. J Biol Chem 276: 6846-6852, 2001

11. Kato K, Ito H, Iwamoto I, Iida K, Inaguma Y: Protein kinase inhibitors suppress stress-induced dissociation of Hsp27. Cell Stress Chap in press

12. Kozawa O, Matsuno H, Niwa M, Hatakeyama D, Kato K, Uemastu T: alpha B-crystallin, a low molecular weight heat shock protein, acts as a regulator of platelet function. Cell Stress Chap in press

13. Katoh-Semba R, Takeuchi I K, Inaguma Y, Ichisaka S, Hata Y, Tsumoto T, Iwai M, Mikoshiba K, Kato K: Induction of brain-derived neurotrophic factor by convulsant drugs in the rat brain: Involvement of region-specific voltage-dependent calcium channels. J Neurochem in press

14. Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, Kitoh H, Mutoh N, Yamanaka T, Mushiake K, Kato K, Sonta S, Nagaya M: Mutations in SIP1, encoding Smad interacting protein 1, cause cases of Hirschsprung’s disease characterized by mental retardation, epilepsy, distinct facial features and congenital heart disease. Nat Genet in pres

岸田昭世（広島大学・医学部）

1. Hino Si, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A: Inhibition of the wnt signaling pathway by idax, a novel dvl-binding protein. Mol Cell Biol 21: 21330-21342, 2001

2. Fukui A, Kishida S, Kikuchi A, Asashima M: Effects of rat axin domains on axis formation in Xenopus embryos. Dev Growth Differ 42:489-498, 2000

3. Kadoya T, Kishida S, Fukui A, Hinoi T, Michiue T, Asashima M, Kikuchi A: Inhibition of wnt signaling pathway by a novel axin-binding protein. J Biol Chem 275: 37030-37037, 2000

4. Sakamoto I, Kishida S, Fukui A, Kishida M, Yamamoto H, Hino Si, Michiue T, Takada S, Asashima M, Kikuchi A: A novel ß-catenin-binding protein inhibits ß-catenin-dependent tcf activation and axis formation. J Biol Chem 275: 32871-32878, 2000

5. Hinoi T, Yamamoto H, Kishida M, Takada S, Kishida S, Kikuchi A:Complex formation of adenomatous polyposis coli gene product and axin facilitates glycogen synthase kinase-3 ß -dependent phosphorylation of ß-catenin and down-regulates ß-catenin. J Biol Chem 275: 34399-34406, 2000

佐藤英介（大阪市立大学・大学院医学研究科）

1. Takada Y, Sato EF, Nakajima T, Hosono M, Tsumura M, Inoue M, Yamada R: Granulocyte-colony stimulating factor enhances antitumor effect of hyperthermia. J Hyperthermia 16: 275-286, 2000

2. Nakamura A, Park AM, Nagata K, Sato EF, Tamura T, Inoue M: Oxidative cellular damage associated with transformation of Helicobacter pylori from a bacillary to a coccoid form. Free Radic Biol Med 28: 1611-1618, 2000

3. Inoue M, Nishikawa M, Sato EF, Paku A, Kashiba M, Takehara Y, Utsumi K: Cross-talk between NO and oxyradicals, a supersystem that regulates energy metabolism and survival of animals. Free Radic Res 33: 757-770, 2000

4. Tsuchiya M, Maeda K, Sato EF, Ohnishi Y, Shindo M, Asada A, Inoue M: Propofol versus midazolam regarding their antioxidant activities. Am J Res Crit Car Med 163: 1-6, 2001

5. Tomita M, Sato EF, Nishikawa M, Yamano Y, Inoue M: Nitric oxide regulates mitochondrial respiration and functions of articular chondrocytes. Arthritis Rheum 44: 96-104, 2001

6. Goto T, Kono T, Ishii M, Sato EF: Supressive effects of cyclosporin A and FK-506 on superoxide generation in human polymorphonuclear leukocytes primed by TNF-a. J Invest Dermatol in press

7. Nishikawa M, Nagatomi H, Chang B-J, Sato EF, Inoue M: Targeting superoxide dismutase to renal proximal tubule cells inhibits mitochondrial injury and renal dysfunction induced by cisplatin. Arch Biochem Biophys in press

8. Nishikawa M, Nishiguchi S, Tamori A, Koh N, Takeda T, Shiomi S, Kubo S, Hirohashi K, Kinoshita H, Sato EF, Inoue M: Somatic mutation of mitochondrial DNA in cancerous and noncancerous liver tissue in individuals with hepatocellular carcinoma. Cancer Res in press

9. Nishikimi A, Kira Y, Kasahara E, Sato EF, Kanno T, Utsumi K, Inoue M: Tributyltin interacts with thiol groups in adenine nucleotide translocator therby inducing cytochrome c release. Biochem J in press

10. Kira Y, Sato EF, Inoue M: Association of Cu, Zn-SOD with membrane of mitochondria amd peroxisomes. Free Radic Biol Med in press

辛龍雲（東北大学・大学院医学系研究科）

1. Higuchi M, Tashiro M, Arai H, Okamura N, Hara S, Higuchi S, Itoh M, Shin R-W, Trojanowski JQ, Sasaki H: Glucose hypometabolism and neuropathological correlates in brains of dementia with Lewy bodies. Exp Neurol 162: 247-256, 2000

鈴木利治（東京大学・大学院薬学系研究科；3/16/2001より北海道大学大学院薬学研究科）

1. Tomita S, Fujita T, Kirino Y, Suzuki T: PDZ domain-dependent suppression of NF-kB/p65-induced Aβ42 production by a neuron specific X11-like protein. J Biol Chem 275: 13056-13060, 2000

2. Lee D-S, Tomita S, Kirino Y, Suzuki T: Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem 275: 23134-23138, 2000

3. Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Greengard P, Kirino Y, Nairn AC, Suzuki T: Neuron-specific phosphorylation of Alzheimers β-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem 75: 1085-1091, 2000

4. Yagi Y, Tomita S, Nakamura M, Suzuki T: Over-expression of human amyloid precursor protein in Drosophila. Mol Cell Biol Res Commun 4: 43-49, 2000

5. Nakaya T, KawaharaS, Watanabe S, Lee D-S, Suzuki T, Kirino Y: Expression and function of a novel gene in odor-taste associative learning in the terrestrial slug. Genes Cells 6: 43-56, 2000

住本英樹（九州大学・大学院医学系研究科）

1. Shiose A, Sumimoto H: Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase. J Biol Chem 275: 13793-13801, 2000

2. Takeya R, Takeshige K, Sumimoto H: Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors. Biochem Biophys Res Commun 267: 149-155, 2000

3. Tanaka H, Takeya R, Sumimoto H: A novel intracellular membrane-bound calcium-independent phospholipase A2. Biochem Biophys Res Commun 272: 320-326, 2000

4. Shiose A, Kuroda J, Tsuruya K, Hirai M, Hirakata H, Naito S, Hattori M, Sakaki Y, Sumimoto H: A novel superoxide-producing NAD(P)H oxidase in kidney. J Biol Chem 276, 1417-1423, 2001

5. Noda Y, Takeya R, Ohno S, Naito S, Ito T, Sumimoto H: Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C. Genes Cells 6: 107-119, 2001

武田篤（東北大学・大学院医学系研究科）

1. Takeda A, Perry G, Abraham NG, Dwyer BE, Kutty RK, Laitinen JT, Petersen RB, Smith MA: Overexpression of heme oxygenase in neuronal cells, the possible interaction with tau. J Biol Chem 275: 5395-5399, 2000

2. Gerst JL, Raina AK, Pirim I, Mcshea A, Harris PL, Siedlak SL, Takeda A, Petersen RB, Smith MA: Altered cell-matrix associated ADAM proteins in Alzheimer disease. J Neurosci Res 59: 680-684, 2000

3. Tateyama M, Tobita M, Takeda A, Chida K, Onodera Y, Kikuchi A, Aoyagi N, Itoyama Y: DNA single-strand breaks are increased in muscle diseases with rimmed vacuoles. Acta Neuropathol 100: 390-394, 2000

4. Kimpara T, Takeda A, Yamaguchi T, Arai H, Okita N, Takase S, Sasaki H, Itoyama Y: Increased bilirubin and its derivatives in cerebrospinal fluid in Alzheimer's disease. Neurobiol Aging 21: 551-554, 2000

5. Hasegawa T, Yamaguchi K, Wada T, Takeda A, Itoyama Y, Miyagi T: Molecular cloning of mouse ganglioside sialidase and its increased expression in neuro2a cell differentiation. J Biol Chem 275: 8007-8015, 2000

6. Yamakawa K, Kuroda H, Fujihara K, Sato S, Nakashima I, Takeda A, Suzuki K, Itoyama Y: Familial neuromyelitis optica (Devic’s syndrome) with late onset in Japan. Neurology 55: 318-320, 2000

7. Iwasaki K, Wang Q, Seki H, Satoh K, Takeda A, Arai H, Sasaki H: The effects of the traditional chinese medicine, “Banxia Houpo Tang (Hange-Koboku To)” on the swallowing reflex in Parkinson’s disease. Phytomedicine 7: 259-263, 2000

8. Takeda A, Smith MA, Avila J, Nunomura A, Siedlak SL, Zhu X, Perry G, Sayre LM: In Alzheimer disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification. J Neurochem 75: 1234-1241, 2000

9. Zhu X, Raina AK, Boux H, Simmons ZL, Takeda A, Smith MA: Activation of oncogenic pathways in degenerating neurons in Alzheimer disease. Int J Dev Neurosci 18: 433-437, 2000

10. Higuchi S, Matsushita S, Nakane J, Arai H, Matsui T, Urakami K, Yuzuriha T, Takeda A: Alpha2-macroglobulin gene polymorphisms show racial diversity and are not associated with Alzheimer's disease. NeuroReport 11: 1167-1171, 2000

11. Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA: Activation of p38 kinase links tau phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59: 880-888, 2000

12. Kanda A, Ebihara S, Arai H, Takeda A, Sasaki H: Parkinson’s disease and impaired chemosensitivity to hypoxia. Lancet 356: 2100, 2000

13. Kimura M, Matsushita S, Arai H, Takeda A, Higuchi S: No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson’s disease. Ann Neurol 49: 276-277, 2000

武田雅俊（大阪大学・大学院医学系研究科）

1. Mizuno-Matsumoto Y, Date S, Tabuchi Y, Tamura S, Sato Y, Zoroofi RA, Shimojo S, Kadobayashi Y, Tatsumi H, Nogawa H, Shinosaki K, Takeda M, Inouye T, Miyahara H: Telemedicine for evaluation of brain function by metacomputer. IEEE Transact Inform Technol Biomed 4: 165-172, 2000

2. Kudo T, Mima T, Morihara T, Tanimukai H, Tsujio I, Hashimoto R, Koike Y, Tagami S, Mori H, Nakamura Y, Tanaka T, Horibe K, Sato K, Oi S, Matsuda H, Moritake K, Mori K, Shinosaki K, Takeda M: Tau protein is a potential biological marker for normal pressure hydrocephalus. Psychiat Clin Neurosci 54: 199-202, 2000

3. Shinosaki K, Nishikawa T,Kobayashi T , Nishimura T, Sawa Y, Akashi K, Tabushi K, Azuma A, Fujimoto O, Uenishi K, Ito K, Yoshida I, Tsutsumi S, Yagasaki A, Niigawa H, Tejima Y, Kondo H, Tanaka K, Tsuda T, Tsuchiyama M, Kotani K, Okubo K, Takeda M: Usefulness of aniracetam in treating emotional disturbances and problematic behavior due to sequelae of cerebral infarction. Int J Geriat Psychopharmacol 2: 73-82, 2000

4. Tsujio I, Tanaka T, Kudo T, Nishikawa T, Shinozaki K, Grundke-Iqbal I, Iqbal K, Takeda M: Inactivation of glycogen synthase kinase-3 by protein kinase C delta: implications for regulation of tau phosphorylation. FEBS Lett 469: 111-117, 2000

5. Iwase M, Nakao K, Takaishi J, Yorifuji K, Ikezawa K, Takeda M: An empirical classification of social anxiety: Performance. Interpersonal and offensive. Psychiat Clin Neurosci 54: 67-75, 2000

6. Nakao K, Takaishi J, Tatsuta K, Katayama H, Iwase M, Yorifuji K, Takeda M: The influences of family environment on personality traits. Psychiat Clin Neurosci 54: 91-95, 2000

7. Homma A, Takeda M, Imai Y, Udaka F, Hasegawa K, Kameyama M, Nishimura T and E2020 Study group: Clinical efficacy and safety of donepezil on cognitive and global function in patients with Alzheimer's disease-24 week, multi-center, double-blind, placebo controlled study in Japan- Dementia Geriat Cogn Dis 11: 299-313, 2000

8. Nakamura Y, Hashimoto R, Kashiwagi Y, Aimoto S, Fukusho E, Matsumoto N, Kudo T, Takeda M: Major phosphorylation site (Ser55) of neurofilament L by cyclic AMP-dependent protein kinase in rat primary neuronal culture. J Neurochem 74: 949-959, 2000

9. Yasuno F, Nishikawa T, Tokunaga H, Yoshiyama K, Nakagawa Y, Ikejiri Y, Oku N, Hashikawa K, Tanabe H, Shinosaki K, Sugita Y, Nishimura T, Takeda M: The neuronal basis of perceptual and conceptual word priming- a PET study. Cortex 36: 59-69, 2000

10. Tanaka T, Tsujio I, Nishikawa T, Shinosaki K, Kudo T, Takeda M: Significance of tau phosphorylation and protein kinase regulation in the pathogenesis of Alzheimer disease. Alzheimer Dis Assoc Disord 14 (supple 1): S18-S24, 2000

11. Kudo T, Imaizumi K, Tanimukai H, Katayama T, Sato M, Nakamura Y, Tanaka T, Kashiwagi Y, Jinno Y, Tohyama M, Takeda M: Are cerebrovascular factors involved in Alzheimer's disease? Neurobiol Aging 21: 215-224, 2000

12. Mizuta I, Fukunaga T, Sato H, Ogasawara M, Takeda M, Inoue Y: A case report of comorbid eating disorders and factitious disorder. Psychiat Clin Neurosci 54: 603-606, 2000

13. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Tamura K, Goto T, Aimoto S, Kaibuchi K, Shiosaka S, Takeda M: Site-specific phosphorylation of neurofilament-L is mediated by calcium/calmodulin-dependent protein kinase 2 in the apical dendrites during long-term potentiation. J Neurochem 75: 373-382, 2000

14. Hashimoto R, Nakamura Y, Komai S, Kashiwagi Y, Matsumoto N, Shiosaka S, Takeda M: Phosphorylation of neurofilament L during LTD. NeuroReport 11: 2739-2742, 2000

15. Nakamura Y, Hashimoto R, Amano M, Nagata K, Matsumoto N, Goto H, Fukusho E, Mori H, Kashiwagi Y, Kudo T, Inagaki M, Takeda M: Localized phosphorylation of vimentin by Rho-kinase in neuroblastoma N2a cells. Genes Cells 5: 823-837, 2000

16. Ishii R, Shinosaki K, Ikejiri Y, Ukai S, Yamashita K, Iwase M, Mizuno-Matsumoto Y, Inoue T, Yoshimine T, Hirabuki N, Robinson SE, Takeda M: Theta rhythm increases in the left superior temporal cortex during auditory hallucinations in schizophrenia. NeuroReport 11: 3283-3287, 2000

17. Yasuno F, Nishikawa T, Nakagawa Y, Ikejiri Y, Tokunaga H, Mizuta I, Shinozaki K, Hashikawa K, Sugita Y, Nishimura T, Takeda M: Functional anatomical study of psychogenic amnesia. Psychiat Res 99: 43-57, 2000

18. Shinosaki K, Nishikawa T, Takeda M: Neurobiological basis of behavioral and psychological symptoms in dementia of the Alzheimer type. Psychiat Clin Neurosci 54: 611-620, 2000

19. Sumi N, Nan'no H, Figimoto O, Ohta Y, Takeda M: Interpeak latency of auditory event-related potentials (P300) in senile depression and dementia of the Alzheimer type. Psychiat Clin Neurosci 54: 679-684, 2000

20. Watanabe T, Mikami A, Kumanogo T, Suganuma N, Shigedo Y, Motonishi M, Honda H, Kyotani K, Uruha S, Terashima K, Teshima T, Takeda M, Sugita Y: The relationship between esophageal pressure and apnea hypopnea index in obstructive sleep apnea-hypopnea syndrome. Sleep Res Online 3: 169-172, 2000

21. Watanabe T, Mikami A, Shigedo Y, Motonishi M, Honda H, Kyotani K, Uruha S, Terashima K, Teshima Y, Sugita Y, Takeda M: Esophageal pressure and apnea hypopnea index in sleep-disordered breathing. Psychiat Clin Neurosci 54: 338-339, 2000

22. Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y: A novel protein, RTN-xs, interacts with both Bcl-xL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity. Oncogene 19: 5736-5746, 2000

田代朋子（青山学院大学・理工学部）

1. Uchida A, Komiya Y, Tashiro T, Yorifuji H, Kishimoto T, Nabeshima Y, Hisanaga S: The neurofilaments of Klotho, the mutant mouse prematurely displaying syndromes resembling human aging. J Neurosci Res in press

2. Aihara Y, Inoue T, Tashiro T, Okamoto K, Komiya Y, Mikoshiba K: Movement of endoplasmic reticulum in the living axon is distinct from other membranous vesicles in its rate, form and sensitivity towards microtubule inhibitors. J Neurosci Res in press

玉岡晃（筑波大学・臨床医学系）

1. Matsuno S, Tamaoka A, Yoshizawa K, Watanabe M, Shoji S: A case with mysthenia gravis (MG) emerging after splenectomy for idiopathic thrombocytopenic purpura (ITP): possible effects of thymectomy on autoantibodies. J Med in press

2. Tokuda T, Tamaoka A, Matsuno S, Sakurai S, Shimada H, Morita H, Ikeda S: Plasma levels of amyloid β proteins did not differ between subjects with and without taking statins. Ann Neurol in press

3. Ishii K, Lippa C, Tomiyama T, Miyatake F, Ozawa K, Tamaoka A, Hasegawa T, Fraser PE, Shoji S, Nee LE, Pollen DA, St. George-Hyslop PH, Ii K, Ohtake T, Kalaria RN, Rossor MN, Lantos PL, Cairns NJ, Farrer LA, Mori H: Distinguishable effects of presenilin-1 and APP717 mutations on amyloid plaque deposition. Neurobiol Aging in press

4. Hoshi K, Yoshida K, Nakamura A, Tada T, Tamaoka A, Ikeda S: Cessation of cerebral hemorrhage recurrence associated with corticosteroid treatment in a patient with cerebral amyloid angiopathy. Amyloid 7: 284-288, 2000

5. Cavani S, Tamaoka A, Moretti A, Marinelli L, Angelini G, Di Stefano S, Piombo G, Cazzulo V, Matsuno S, Shoji S, Furiya Y, Zaccheo D, Dagna-Bricarelli F, Tabaton M, Mori H: Plasma levels of amyloid beta 40 and 42 are independent from ApoE genotype and mental retardation in down syndrome. Am J Med Genet 95: 224-228, 2000

6. Tamaoka A, Matsuno S, Ono S, Shimizu N, Shoji S: Increased amyloid β protein in the skin of patients with amyotrophic lateral sclerosis. J Neurol 247: 633-635, 2000

7. Tamaoka A, Miyatake F, Matsuno S, et al: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease. Neurology 54: 2319-2321, 2000

8. Yausda M, Maeda S, Kawamata T, Tamaoka A, Yamamoto Y, Kuroda S, Maeda K, Tanaka C: Novel presenilin-1 mutation with widespread cortical amyloid deposition but limited cerebral amyloid angiopathy. J Neurol Neurosurg Psychiat 68: 220-223, 2000

9. Mochizuki A, Tamaoka A, Shimohata A, Komatsuzaki Y, Shoji S: Abeta42-positive non-pyramidal neurons around amyloid plaques in Alzheimer's disease. Lancet 355: 42-43, 2000

10. Harada H, Ohkoshi N, Fujita Y, Tamaoka A, Shoji S: Clinical improvement following interferon-alpha alone as an initial treatment in chronic inflammatory demyelinating polyneuropathy with chronic hepatitis C. Muscle Nerve 23: 295-296, 2000

内木宏延（福井医科大学・医学部）

1. Yamaguchi I, Hasegawa K, Naiki H, Mitsu T, Matuo Y, Gejyo F: Extension of Aβ2M amyloid fibrils with recombinant human β-microglobulin. Amyloid in press

鍋島俊隆（名古屋大学・大学院医学研究科）

1. Han D, Yamada K, Senzaki K, Xiong H, Nawa H, Nabeshima T: Involvement of nitric oxide in pentylenetetrazol-induced kindling in rats. J Neurochem 74: 792-798, 2000

2. Iida R, Saito K, Yamada K, Basile AS, Sekikawa K, Takemura M, Fujii H, Wada H, Seishima M, Nabeshima T: Suppression of neurocognitive damage in LP-BM5 infected mice with a targeted deletion of the TNFa gene. FASEB J 14:1023-1031, 2000

3. Tang P-Y, Yamada K, Kanou Y, Miyazaki T, Xiong X-L, Kambe F, Murata Y, Seo H, Nabeshima T: Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of b-amyloid in rats. Mol Brain Res 80:188-197, 2000

4. Zou L-B, Yamada K, Sasa M, Nakata Y, Nabeshima T: Effects of sigma 1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats. Neuropharmacology 39:1617-1627, 2000

5. Mamiya T, Noda Y, Noda A, Hiramatsu M, Karasawa T, Kameyama T, Furukawa S, Yamada K, Nabeshima T: Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in mice. Neuropharmacology 39: 2391-2398, 2000

6. Mizuno M, Yamada K, Olariu A, Nawa H, Nabeshima T: Involvement of BDNF in spatial memory formation and maintenance in a radial arm maze test in rats. J Neurosci 20: 7116-7121, 2000

7. Yamada K, Iida R, Miyamoto Y, Saito K, Sekikawa K, Seishima M, Nabeshima T: Neurobehavioral alterations in mice with a targeted deletion of the tumor necrosis factor-a gene: implications for emotional behavior. J Neuroimmunol 111: 131-18, 2000

8. Itoh A, Shiotani T, Nakayama S, Mamiya T, Hasegawa T, Noda Y, Nabeshima T: Attenuatioon of the development of morphine dependence/tolerance by nefiracetam: involvement of adenosine 3’:5’ -cyclic monophosphate system. Behav Brain Res 115: 65-74, 2000

9. Miyamoto Y, Noda Y, Komori Y, Sugihara H, Furukawa H, Nabeshima T: Involvement of nitric oxide in phencyclidine-induced place aversion and preference in mice. Behav Brain Res 116: 187-196, 2000

10.Shiotani T, Nakamoto Y, Watabe S, Yoshii M, Nabeshima T: Anticonvulsant actions of nefiracetam on epileptic EL mice and their relation to peripheral-type benezodiazepine receptors. Brain Res 859: 255-261, 2000

11. Kobayashi K, Noda Y, Matsushita N, Nishii K, Sawada H, Nagatsu T, Nakahara D, Fukabori R, Yasoshima Y, Yamamoto T, Miura M, Kano M, Mamiya T, Miyamoto Y, Nabeshima T: Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene. J Neurosci 20: 2418-2426, 2000

12. Noda Y, Kamei H, Kamei Y, Nagai T, Nishida M, Nabeshima T: Neurosteroids ameliorate conditioned fear stress: An association with sigma₁ receptors. Neuropsychopharmacology 23: 276-284, 2000

13. Noda Y, Kamei H, Mamiya T, Furukawa H, Nabeshima T: Repeated phencyclidine treatment induces negative symptom-like behavior in forced swimming test in mice: Imbalance of prefrontal serotonergic and dopaminergic functions. Neuropsychopharmacology 23: 375-387, 2000

14. Kato K, Shishido T, Ono M, Shishido K, Kobayashi M, Suzuki H, Nabeshima T, Furukawa H, Niwa S: Effects of phencyclidineon behavior and extracelluar levels of dopamine and its metabolites in neonatal ventral hippocampal damaged rats. Psychopharmacology 150: 163-169, 2000

15. Mori A, Noda Y, Mamiya T, Miyamoto Y, Nakajima A, Furukawa H, Nabeshima T: Phencyclidine-induced discriminative stimulus is mediated via phencyclidine binding sites on the N-methyl-D-aspartate receptor-ion channel complex, not via sigma₁ receptors. Behav Brain Res 119: 33-40, 2000

16. Hamdy MM, Mamiya T, Noda Y, Sayed M, Assi A-A, Gomaa A, Yamada K, Nabeshima T: A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice. Behav Brain Res 118: 85-93, 2001

17. Miyamato Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T: Hyperfunction of dopaminergic and serotonergic neuronal systems in mice lacking NMDA receptor e1 subunit. J Neurosci 21: 750-757, 2001

18. Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, Sanbo M, Yagi T, Inoue Y, Nabeshima T, Mori H, Mishina M: Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci 13: 179-189, 2001

19. Mamiya T, Noda Y, Ren X, Hamdy M, Furukawa S, Kameyama T, Yamada K and Nabeshima T: Involvement of the cyclic AMP systems in morphine physical dependence in mice: prevention of development of dependence by rolipram, a phosphodiesterase IV inhibitor. Br J Pharmacol in press

20. Tran MH, Yamada K, Olariu A, Mizuno M, Ren XH, Nabeshima T: Amyloid β-peptide induces nitric oxide production in rat hippocampus: association with cholinergic dysfunction and amelioration by inducible nitric oxide synthase inhibitors. FASEB J in press

21. Noda A, Noda Y, Ichihara K, Mamiya T, Nagai T, Sugiura S, Furukawa H, Nabeshima T: Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma₁ receptors. Neuropsychopharmacology in press

22. Qiao H, Noda Y, Kamei H, Nagai T, Furukawa H, Miura H, Kayukawa Y, Ohta T, Nabeshima T: Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment. NeuroReport in press

23. Fukuta T, Nitta A, Itoh A, Furukawa S, Nabeshima T: Difference in toxicity of amyloid b peptide with aging in relation to nerve growth factor content in rat brain. J Neural Transm in press

藤野貴広（東北大学・遺伝子実験施設）

1. Fujino T, Kondo J, Ishikawa M, Morikawa K, Yamamoto TT: Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate. J Biol Chem in press

2. Cho Y-Y, Kang M-J, Ogawa S, Yamashita Y, Fujino T, Yamamoto TT: Regulation by adrenocorticotropic hormone and arachidonate of the expression of acyl-CoA synthetase 4, an arachidonate-preferring enzyme expressed in steroidogenic tissues. Biochem Biophys Res Commun 274: 741-745, 2000

古川勝敏（東北大学・医学部付属病院）

1. Furukawa K, D'Souza I, Crudder CH, Onodera H, Itoyama Y, Poorkaj P, Bird TD, Schellenberg GD: Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia with parkinsonism. NeuroReport 11: 57-60, 2000

満田憲昭（愛媛大学・医学部）

1. Mitsuda N, Ohkubo N, Tamatani M, Lee YD, Taniguchi M, Namikawa K, Kiyama H, Yamaguchi A, Sato N, Ogihara T, Vitek MP, Tohyama M: Activated CREB regulates neuronal expression of presenilin-1. J Biol Chem in press

2. Ohkubo N, Mitsuda N, Tamatani M, Yamaguchi A, Lee YD, Ogihara T, Vitek MP, Tohyama M: Apolipoprotein E4 stimulates CREB's transcriptional activity through the ERK pathway. J Biol Chem 276: 3046-3053, 2001

3. Yamaguchi A, Tamatani M, Matsuzaki H, Namikawa K, Kiyama H, Vitek MP, Mitsuda N, Tohyama M: Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. J Biol Chem 276: 5256-5264, 2001

4. Hatanaka Y, Kamino K, Fukuo K, Mitsuda N, Nishiwaki-Ueda Y, Sato N, Satoh T, Yamamoto H, Yoneda H, Imagawa M, Miki T, Ohta S, Ogihara T: Low density lipoprotein receptor-related protein gene polymorphisms and risk for late-onset Alzheimer's disease in a Japanese population. Clin Genet 58: 319-323, 2000

5. Tamatani M, Mitsuda N, Matsuzaki H, Okado H, Miyake S, Vitek MP, Yamaguchi A, Tohyama M: A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2. J Neurochem 75: 683-693, 2000

武藤多津郎（福井医科大学・医学部附属病院）

1. Mutoh T, Sobue G, Hamano T, Kuriyama M, Hirayama M, Yamamoto M, Mitsuma T: Decreased tyrosine phosphorylation of TrkB receptor in the spinal cords from the patients with amyotrophic lateral sclerosis. Neurochem Res 25: 239-245, 2000

2. Hamano T, Mutoh T, Sugie H, Koga H, Kuriyama M: Phosphoglycerate kinase deficiency. An adult myopathic form with a novel mutation. Neurology 54: 1188-1190, 2000

3. Kumano T, Mutoh T, Nakagawa H, Kuriyama M: HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, Trk, and morphological differentiation with fatal outcome in PC12 cells. Brain Res 859: 169-172, 2000

4. Fukumoto S, Mutoh T, Hasegawa T, Miyazaki H, Okada M, Goto G, Furukawa K, Urano T, Furukawa K: GD3 synthase gene expression in PC12 cells resulted in the continuous activation of TrkA and ERK1/2, leading to enhanced proliferation. J Biol Chem 275: 5832-5838, 2000

5. Hamano T, Miyoshi Y, Hirayama M, Hiraki S, Mutoh T, Kuriyama M: Posterior thoracic spinal cord infarction: Complication of thoracoabdominal aortic aneurysm. Eur Neurol 44: 59-60, 2000

6. Mutoh T, Hamano T, Tokuda A, Kuriyama M: Unglycosylated Trk protein does not co-localize nor associate with gangliosides GM1 in stable clone overexpressing Trk of PC12 cells (PCtrk). Glycoconj J 17: 233-237, 2000

7. Hirayama M, Mutoh T, Tokuda A: Acid hydrolase activity of cultured bovine oligodendrocytes. Neurochem Res 26: 121-124, 2001

森啓（大阪市立大学・大学院医学研究科）

1. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido TC, Mori H, Ishiura S: Molecular interactions between presenilin and calpain: Inhibition of μ-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. Int J Mol Med 5: 269-273, 2000

2. Lippa CF, Schmidt ML, Nee LE, Bird T, Nochlin D, Hulette C, Mori H, Lee VM-Y, Trojanowski JQ: AMY plaques in familial AD; comparison with sporadic Alzheimer's disease. Neurology 54: 100-104, 2000

3. Sahara N, Tomiyama T, Mori H: Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation. J Neurosci Res 60: 380-387, 2000

4. Tamaoka A, Miyatake F, Matsuno S, Ishii K, Nagase S, Sahara N, Ono S, Mori H, Wakabayashi K, Tsuji S, Takahashi H, Shoji, S: Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease. Neurology 54: 2319-2321, 2000

5. Shimizu T, Watanabe A, Ogawara M, Mori H, Shirasawa T: Isoaspartate formation and neurodegeneration in Alzheimer's disease. Arch Biochem Biophys 381: 225-234, 2000

6. Cavani S, Tamaoka A, Moretti A, Marinelli L, Angelini G, Di Stefano S, Piombo G, Cazzulo V, Matsuno S, Shoji S, Furiya Y, Zaccheo D, Dagna-Bricarelli F, Tabaton M, Mori H: Plasma levels of amyloid ß40 and 42 are independent from apoE genotype and mental retardation in Down syndrome. Am J Med Genet 95: 224-228, 2000

7. Pigino G, Pelsman A, Mori H, Busciglio J: Presenilin 1 mutations reduce cytoskeletal association, deregulate neurite growth and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21: 834-842, 2001

山口晴保（群馬大学・医学部）

1. Yamaguchi H, Maat-Schieman ML, van Duinen SG, Prins FA, Neeskens P, Natte R, Roos RA: Amyloid β protein (Ab) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects. J Neuropathol Exp Neurol 59: 723-732, 2000

2. Morishima-Kawashima M, Oshima N, Ogata H, Yamaguchi H, Yoshimura M, Sugihara S, lhara Y: Effect of apolipoprotein E allele e4 on the initial phase of amyloid ß-protein accumulation in the human brain. Am J Pathol 157: 2093-2099, 2000

3. Thal DR, Schultz C, Dehghani F, Yamaguchi H, Braak H, Braak E: Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Ab deposits in the human entorhinal cortex. Acta Neuropathol 100: 608-617, 2000

4. Kokubo H, Lemere CA, Yamaguchi H: Localization of flotillins in human brain and their accumulation with the progression of Alzheimer's disease pathology. Neurosci Lett 290: 93-96, 2000

5. Tsuzuki K, Fukatsu R, Yamaguchi H, Tateno M, Imai K, Fujii N, Yamauchi T: Transthyretin binds amyloid b peptides, Aβ1-42 and Aβ1-40 to form complex in the autopsied human kidney - possible role of transthyretin for Aβ sequestration. Neurosci Lett 281: 171-174, 2000

6. Fakla I, Kovacs I, Yamaguchi H, Geula C, Kasa P: Expressions of amyloid precursor protein, synaptophysin and presenilin-1 in the different areas of the developing cerebellum of rat. Neurochem Int 36: 143-151, 2000

7. Kasa P, Papp H, Kovacs I, Forgon M, Penke B, Yamaguchi H: Human amyloid-b1-42 applied in vivo inhibits the fast axonal transport of proteins in the sciatic nerve of rat. Neurosci Lett 278: 117-119, 2000

8. Maat-Schieman ML, Yamaguchi H, van Duinen SG, Natte R, Roos RA: Age-related plaque morphology and C-terminal heterogeneity of amyloid ß in Dutch-type hereditary cerebral hemorrhage with amyloidosis. Acta Neuropathol 99: 409-419, 2000

横山信治（名古屋市立大学・医学部）

1. Ito J-I, Yokoyama S: Sialosylcholesterol induces reorganization of astrocyte filament network. Biochim Biophys Acta 1495: 195-202, 2000

2. Ito J-I, Nagayasu Y, Yokoyama S: Cholesterol-sphingomyelin interaction in membrane and apolipoprotein-mediated cellular cholesterol efflux. J Lipid Res 41: 894-904, 2000

3. Tsujita M, Tomimoto S, Okumuya-Noji K, Okazaki M,Yokoyama S: Apolipoprotein-mediated cellular cholesterol/phospholipid efflux and plasma high density lipoprotein level in mice. Biochim Biophys Acta 1485: 199-213, 2000

4. Teo KK, Burton JR, Buller CE, Plante S, Catellier D, Tymchak W, Dzavik V, Taylor D, Yokoyama S, Montague TJ on behalf of the SCAT investigators: Long term effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: The Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT). Circulation 102: 1748-1754, 2000

5. Abe-Dohmae S, Suzuki S, Wada Y, Aburatani H, Vance DE, Yokoyama S: Characterization of apolipoprotien-mediated HDL generation induced by cAMP in a murine macrophage cell line. Biochemistry 39: 11092-11099, 2000

6. Arakawa R, Abe-Dohmae S, Asai M, Ito J-I, Yokoyama S: Involvement of caveolin-1 in cholesterol-enrichment of HDL during its assembly by apolipoprotein and THP-1 cells. J Lipid Res 41: 1952-1962, 2000

7. Suzuki S, Dohmae S, Fukutomi T, Ito S, Itoh M, Yokoyama S: Enhancement of the cAMP-induced apolipoprotein A-I-mediated cellular lipid release by calmodulin inhibitors W7 and W5 from RAW264 mouse macrophage cell line cells. J Cardiovasc Pharmacol 36: 609-616, 2000

8. Zhang L-Y, Ito J-I, Kato T, Yokoyama S: Cholesterol homeostasis in rat astrocytoma cells GA-1. J Biochem (Tokyo) 128: 837-845, 2000

9. Tomimoto S, Tsujita M, Okazaki M, Usui S-I, Tada T, Ito S, Itoh M, Yokoyama S: Effect of probucol in lecithin-cholesterol acyltransferase deficient mice: Inhibition of two independent cellular cholesterol releasing pathways in vivo. Arterioscler Thromb Vasc Biol 21: 394-400, 2000

和栗聡（大阪大学・大学院医学系研究科）

1. Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E, Peters C, von Figura K, Uchiyama Y: Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci 20: 6898-6906, 2000

和中明生（福島県立医科大学・医学部）

1. Takeda J, Sato Y, Kiyosawa H, Mori T, Yokoya S, Irisawa A, Miyata M, Obara K, Fujita T, Suzuki T, Kasukawa R, Wanaka A: Anti-tumor immunity against CT26 colon tumor in mice immunized with plasmid DNA encoding beta-galactosidase fused to an envelope protein of endogenous retrovirus. Cell Immunol 204: 11-18, 2000

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