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B01班

三品昌美（東京大学・大学院医学系研究科）

1. Inoue M, Mishina M, Ueda H: Enhanced nociception by exogenous and endogenous substance P given into the spinal cord in mice lacking NR2A/e1, an NMDA receptor subunit. Br J Pharmacol 129: 239-241, 2000

2.Ito I, Kawakami R, Sakimura K, Mishina M, Sugiyama H: Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses. Neuropharmacology 39: 943-951, 2000

3.Minami T, Okuda-Ashitaka E, Mori H, Sakimura K, Watanabe M, Mishina M, Ito S: Characterization of nociceptin/orphanin FG-induced pain responses in conscious mice: Neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluR e subunit knockout mice. Neuroscience 97: 133-142, 2000

4. Hironaka K, Umemori H, Tezuka T, Mishina M, Yamamoto T: The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor d2 and e subunits. J Biol Chem 275: 16167-16173, 2000

5. Matsuda I, Mishina M: Identification of a juxtamembrane segment of the glutamate receptor d2 subunit required for the plasma membrane localization. Biochem Biophys Res Commun 275: 565-571, 2000

6. Nakamura K, Manabe T, Watanabe M, Mamiya T, Ichikawa R, Kiyama Y, Sanbo M, Yagi T, Inoue Y, Nabeshima T, Mori H, Mishina M: Enhancement of hippocampal LTP, reference memory and sensorimotor gating in mutant mice lacking a telencephalon-specific cell adhesion molecule. Eur J Neurosci 13: 179-189, 2001

7. Nakazawa T, Komai S, Tezuka T, Hisatsune C, Umemori H, Semba K, Mishina M, Manabe T, Yamamoto T: Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR e2 (NR2B) subunit of the N-methyl-D-aspartate receptor. J Biol Chem 276: 693-699, 2001

8. Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T: Hyperfunction of dopaminergic and serotonergic neural systems in mice lacking NMDA receptor e1 subunit. J Neurosci 21: 750-757, 200

9. Uchino S, Nakamura T, Nakamura K, Nakajima-Iijima S, Mishina M, Kohsaka S, Kudo Y: Real-time two-dimensional visualization of ischemia-induced glutamate release from hippocampal slices. Eur J Neurosci 13: 670-678, 2000 10. Kishimoto Y, Kawahara S,Mori H,Mishina M, Kirino Y: Long-trace interval eyeblink conditioning is impaired in mutant mice lacking the NMDA receptor subunit e1. Eur J Neurosci 13: 1221-1227, 2001

11. Kishimoto Y, Kawahara S, Suzuki M, Mori H, Mishina M, Kirino Y: Classical eyeblink conditioning in glutamate receptor subunit e2 mutant mice is impaired in the delay paradigm but not in the trace paradigm. Eur J Neurosci 13: 1249-1253, 2001

12. Kitayama K, Abe M, Kakizaki T, Honma D, Natsume R, Fukaya M, Watanabe M, Miyazaki J, Mishina M, Sakimura K: Purkinje cell specific and inducible gene recombination system generated from C57BL/6 mouse ES cells. Biochem Biophys Res Commun in press

平野丈夫（京都大学・大学院理学研究科）

1. Kawaguchi S, Hirano T: Suppression of inhibitory synaptic potentiation by presynaptic activity through postsynaptic GABA_B receptors in a Purkinje neuron. Neuron 27: 339-347, 2000

2. Imamura Y, Inokawa H, Ito A, Kadotani H, Toyama K, Noda S, Nakanishi S, Hirano T: Roles of GABAergic inhibition and NMDA receptor subunits in the spatio-temporal integration in the cerebellar cortex of mice. Neurosci Res 38: 289-301, 2000

3. Iwashita M, Kanai R, Funabiki K, Matsuda K, Hirano T: Dynamic properties, interactions and adaptive modifications of vestibulo-ocular reflex and optokinetic response in mice. Neurosci Res 39: 299-311, 2001

井ノ口馨（三菱化学生命科学研究所、早稲田大学・理工学総合研究センター）

1. Matsuo R, Murayama A, Saitoh Y, Sakaki Y, Inokuchi K:Identification and cataloging of genes induced by long-lasting long-term potentiation in awake rats. J Neurochem 74: 2239-2249, 2000 2. Ikegami S, Inokuchi K: Antisense DNA against calcineurin facilitates memory in contextual fear conditioning by lowering the threshold for hippocampal long-term potentiation induction. Neuroscience 98: 637-646, 2000

3. Saitoh Y, Inokuchi K: A triphasic curve characterizes the retention of lever-pressing behavior rewarded by lateral hypothalamic stimulation during the immediate-posttrial period in rats: implications for a transient intermediate stage between short and long-term memory. Neurosci Res: 37, 211-219, 2000

4. Tanaka T, Sugai M, Ito Y, Inokuchi K, Kohno T: Assignments of the ¹H, ¹³C, and ¹⁵N resonances of the 21 kDa Vesl/Homer family protein, Vesl-1S. J Biomol NMR 18: 181-182, 2000

岡部繁男（東京医科歯科大学・大学院医歯学総合研究科）

1. Kondo M, Okabe S, Sumino R, Okado H: High GluR1/GluR2 expression ratio correlates with expression of Ca²⁺-binding proteins in the rat forebrain neurons. Eur J Neurosci 12: 2812-2822, 2000

河西春郎（岡崎国立共同研究機構・生理学研究所）

1. Nemoto T, Kimura R, Ito K, Tachikawa A, Miyashita Y, Iino M, Kasai H: Sequential-replenishment mechanism of exocytosis in pancreatic acini. Nat Cell Biol 3: 253-258, 2001

2. Kishimoto T, Liu T, Ninomiya Y, Takagi H, Yoshioka T, Ellis-Davies GCR, Miyashita Y, Kasai H: Ion selectivities of the Ca²⁺sensors for exocytosis in rat phaeochromocytoma cells. J Physiol (Lond) in press

3. Tsubamoto Y, Eto K, Noda M, Daniel S, Suga S, Yamashita S, Kasai H, Wakui M, Sharp GW, Kimura S, Kadowaki T: Hexamminecobalt (III) chloride inhibits glucose-induced insulin secretion at the exocytotic process. J Biol Chem 276: 2979-2985, 2001

椛秀人（高知医科大学・医学部）

1. Okere CO, Kaba H: Heterogenous immunohistochemical expression of microglia-specific ionized calcium binding adaptor protein (Iba 1) in the mouse olfactory bulb. Brain Res 877: 85-90, 2000

2. Osako Y, Otsuka T, Taniguchi M, Oka T, Kaba H: Oxytocin depresses spontaneous g-aminobutyric acid-ergic inhibitory postsynaptic currents in cultured mitral cells of the rat olfactory bulb by a presynaptic mechanism. Neurosci Lett 289: 25-28, 2000

3. Okere CO, Kaba H: Region-specific localization of glutamine synthetase immunoreactivity in the mouse olfactory bulb: implication for neuron-glia interaction in bulbar synaptic plasticity. Brain Res 857: 308-312, 2000

4. Zhang J-J, Okutani F, Yagi F, Inoue S, Kaba H: Facilitatory effect of ritanserin is mediated by dopamine D1 receptors on olfactory learning in young rats. Dev Psychobiol 37: 246-252, 2000

5. Okere CO, Kaba H: Increased expression of neuronal nitric oxide synthase mRNA in the accessory olfactory bulb during the formation of olfactory recognition memory in mice. Eur J Neurosci 12: 4552-4556, 2000

6. Osako Y, Otsuka T, Taniguchi M, Oka T, Kaba H: Oxytocin enhances presynaptic and postsynaptic glutamatergic transmission between rat olfactory bulb neurones in culture. Neurosci Lett 299: 65-68, 2001

7. Otsuka T, Ishii K, Osako Y, Okutani F, Taniguchi M, Oka T, Kaba H: Modulation of dendrodendritic interactions and mitral cell excitability in the mouse accessory olfactory bulb by vaginocervical stimulation. Eur J Neurosci in press

桐野豊（東京大学・大学院薬学系研究科）

1. Tomita S, Fujita T, Kirino Y, Suzuki T: PDZ domain-dependent suppression of NF-kB/p65-inducedAb42 production by a neuron-specific X11-like protein. J Biol Chem 275: 13056-13060, 2000

2. Inoue T, Watanabe S, Kawahara S, Kirino Y: Phase-dependent filtering of sensory information in the oscillatory olfactory center of a terrestrial mollusk. J Neurophysiol 84: 1112-1115, 2000

3. Lee D-S, Tomita S, Kirino Y, Suzuki T: Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein. J Biol Chem 275: 23134-23138, 2000

4. Iijima K, Ando K, Takeda S, Satoh Y, Seki T, Itohara S, Greengard P, Kirino Y, Nairn AC, Suzuki T: Neuron-specific phosphorylation of Alzheimer's b-amyloid precursor protein by cyclin-dependent kinase 5. J Neurochem 75: 1085-1091, 2000

5. Lee D-S, Hirashima N, Kirino Y: Rapid transbilayer phospholipid redistribution associated with exocytotic release of neurotransmitters from cholinergic nerve terminals isolated from electric ray Narke japonica,” Neurosci Lett 291: 21-24, 2000

6. Toda S, Kawahara S, Kirino Y: Image analysis of olfactory responses of the procerebrum in the terrestrial slug Limax marginatus. J Exp Biol 203: 2895-2905, 2000

7. Nakaya T, Kawahara S, Watanabe S, Suzuki T, Kirino Y: Expression and function of a novel gene in odor-taste associative learning in the terrestrial slug. Genes Cells 6: 43-56, 2001

8. Kishimoto Y, Kawahara S, Mori H, Mishina M, Kirino Y: Long-trace interval eyeblink conditioning is impaired in mutant mice lacking NMDA receptor subunit e1. Eur J Neurosci 13: 1221-1227, 2001

9. Kishimoto Y, Kawahara S, Suzuki M, Mori H, Mishina M, Kirino Y: Classical eyeblink conditioning in glutamate receptor subunit e2 mutant mice is impaired in delay paradigm but not in trace paradigm. Eur J Neurosci 13: 1249-1253, 2001

10. Watanabe S, Inoue T, Murakami M, Inokuma Y, Kawahara S, Kirino Y: Modulation of oscillatory neural activities by cholinergic activation of interneurons in the olfactory center of a terrestrial slug. Brain Res in press

11. Shindo K, Shinozaki K, Kami K, Anzai K, Lee S, Aoyagi H, Kirino Y, Shimada I: Solution structure of micelle-bound H5 peptide (427-452): a primary structure corresponding to the pore-forming region of the voltage dependent potassium channel. Biochim Biophys Acta in press

12. Satoh Y, Hirakura Y, Shibayama S, Hirashima N, Suzuki T, Kirino Y: b-Amyloid peptides inhibit acetylcholine release from cholinergic presynaptic nerve endings isolated from an electric ray. Neurosci Lett in press

後藤薫（山形大学・医学部）

1. Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N, Saito N: Subtype-specific translocation of diacylglycerol kinase alpha and gamma and its correlation with protein kinase C. J Biol Chem 275: 24760-24766, 2000

小林拓也（京都大学・大学院医学研究科）

1. Kobayashi T, Ushikubi F, Narumiya S: Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors; Identification by site-directed mutagenesis. J Biol Chem 275: 24294-24303, 2000

2. Matsuoka T, Hirata M, Tanaka H, Takahashi Y, Murata T, Kabashima K, Sugimoto Y, Kobayashi T, Ushikubi F, Aze Y, Eguchi N, Urade Y, Yoshida N, Kimura K, Mizoguchi A, Honda Y, Nagai H, Narumiya S: Prostaglandin D2 as a mediator of allergic asthma. Science 287: 2013-2017, 2000

斎藤尚亮（神戸大学・バイオシグナル研究センター）

1. Kajimoto T, Ohmori S, Shirai Y, Sakai N, Saito N: Subtype-specific translocation of δ subtype-PKC and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells. Mol Cell Biol 21: 1769-1783, 2001

2. Nakai M, Tanimukai S, Yagi K, Saito N, Taniguchi T, Terashima A, Kawamata T, Hoji K, Yamamoto H, Fukunaga K, Miyamoto E, Tanaka C: Amyloid β protein activates PKC-δ and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia. Neurochem Int in press

3. Ohmori S, Sakai N, Shirai Y, Yamamoto H, Miyamoto E, Shimizu N, Saito N: Importance of PKC targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrate (MARCKS). J Biol Chem 275: 26449-26457, 2000

4. Shirai Y, Segawa S, Kuriyama M, Goto K, Sakai N, Saito N: Subtype-specific translocation of diacylglycerol kinase α and γ and its correlation with protein kinase C. J Biol Chem 275: 24760-24766, 2000

5. Shirai Y, Kashiwagi K, Sakai N, Saito N: Phospholipase A2 and its products are involved in the purinergic receptor-mediated translocation of protein kinase C in CHO-K1 cells. J Cell Sci 113: 1335-1343, 2000

6. Larsen EC, DiGennaro JA, Saito N, Mehta S, Loegering DJ, Mazurkiewicz JE, Lennartz MR: Differential requirement for classic and novel PKC isoforms in respiratory burst and phagocytosis in RAW 264.7 cells. J Immunol 165: 2809-2817, 2000

7. Sumioka K, Shirai Y, Sakai N, Hashimoto T, Tanaka C, Yamamoto M, Takahashi M, Ono Y, Saito N: Induction of 55 kDa PKN cleavage product by ischemia/reperfusion model in the rat retina. Invest Opthal Vis Sci 41: 29-35, 2000

8. Ueyama T, Ren Y, Ohmori S, Sakai K, Tamaki N, Saito N: cDNA cloning of an alternative splicing variant of protein kinase Cδ (PKCδIII), a new truncated form of PKCδ, in rats. Biochem Biophys Res Commun 269: 557-563, 2000

9. Nakagawa N, Hoshijima M, Oyasu M, Saito N, Tanizawa K, Kuroda S: ENH, containing PDZ and LIM domain, heart/skeletal muscle-specific protein, associates with cytoskeletal protein through its PDZ domain. Biochem Biophys Res Commun 272: 505-512, 2000

10. Yokogawa T, Nagata S, Nishio Y, Tsutsumi T, Ihara S, Shirai R, Morita K, Umeda M, Shirai Y, Saito N, Fukui Y: Evidence that 3’-phosphorylated polyphosphoinositides are generated at the nuclear surface: use of immunostaining technique with monoclonal antibodies specific for PI 3,4-P2, FEBS Lett 473: 222-226, 2000

11. Sakai N, Kodama N, Ohmori S, Sasaki K, Saito N: Involvement of the actin cytoskeleton in the regulation of serotonin transporter (SET) activity: possible mechanism underlying SET regulation by protein kinase C. Neurochem Int 36: 567-579, 2000

12. Oyasu M, Kuroda S, Nakashita M, Fujimiya M, Kikkawa U, Saito N: Immunocytochemical localization of a neuron-specific thrombospondin-1-like protein, NELL2: Light and electron microscopic studies in the rat brain. Mol Brain Res 76: 151-160, 2000

13. Akiyama H, Kondoh T, Kokunai T, Nagashima T, Saito N, Tamaki N: Blood-brain barrier formation of grafted human umbilical vein endothelial cells in athymic mouse brain. Brain Res 858: 172-176, 2000

14. Tanii H, Zang XP, Saito N, Saijoh K: Involvement of GABA neurons in allylnitrile-induced dyskinesia. Brain Res 887: 454-459, 2000

15. Shibaguchi H, Takemura K, Kan S, Kataoka Y, Kaibara M, Saito N Taniyama K: Role of synaptophysin in exocytic release of dopamine from Xenopus oocytes injected with rat brain mRNA. Cell Mol Neurobiol 20: 401-408, 2000

崎村建司（新潟大学・脳研究所）

1. Tanaka J, Nakagawa S, Kushiya E, Yamasaki M, Fukaya M, Iwanaga T, Simon M I, Sakimura K, Kano M, Watanabe M: Gq protein a subunits G aq and G a11 are localized at postsynaptic extra-junctional membrane of cerebellar Purkinje cells and hippocampal pyramidal cells. Eur J Neurosci 12: 781-792, 2000

2. Minami T, Okuda-Ashitaka E, Mori H, Sakimura K, Watanabe M, Mishina M, Ito S: Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: Neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRe subunit knockout mice. Neuroscience 97: 133-142, 2000

3. Ito I, Kawakami R, Sakimura K, Mishina M Sugiyama H: Input-specific targeting of NMDA receptor subtypes at mouse hippocampal CA3 pyramidal neuron synapses. Neuropharmacology 39: 943-951, 2000

4. Yamakura T, Sakimura K, Shimoji K: N-methyl-D-aspartate receptor channel block by meperidine is dependent on extracellular pH. Anesth Analg 90: 928-932, 2000

5. Kitayama K, Abe M, Kakizaki T, Honma D, Natsume R, Fukaya M, Watanabe M, Miyazaki J, Mishina M, Sakimura K: Purkinje cell specific and inducible gene recombination system generated from C57BL/6 mouse ES cells. Biochem Biophys Res Commun in press

曽良一郎（東京都精神医学総合研究所）

1. Qiu Q, Sora I, Ren K, Uhl GR, Dubner R: Enhanced delta-opioid receptor-mediated antinociception in mu-opioid receptor-deficient mice. Eur J Pharmacol 387: 163-169, 2000

2. Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Bian D, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Porreca F: Delta opioid receptor agonists produce antinociception and [³⁵S]GTPs binding in mu-opioid receptor knock-out mice. Eur J Pharmacol 388: 241-248, 2000

3. LaBuda CJ, Sora I, Uhl GR, Fuchs PN: Stress-induced analgesia in mu-opioid receptor knockout mice reveals normal function of the delta-opioid receptor system. Brain Res 869: 1-5, 2000

4. Uhl GR, Li S, Takahashi N, Itokawa K, Lin Z, Hazama M, Sora I: The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J 14: 2459-2465, 2000

5. Wisor J P, Nishino S, Sora I, Uhl GR, Mignot E, Edgar DM: Dopaminergic role in stimulant-induced wakefulness. J Neurosci in press

6. Sora I, Elmer G, Funada M, Pieper J, Li X-F, Hall S, Uhl G R: Mu opiate receptor gene dose effects on different morphine actions: evidence for differential in vivo mu receptor reserve. Neuropsychophamacology in press

7. Hall S, Sora I, Uhl G R: Ethanol consumption and reward are decreased in mu-opiate receptor knockout mice. Psychopharmacology in press

田中秀和（大阪大学・大学院医学系研究科）

1. Tanaka H, Shan W, Phillips GR, Arndt K, Bozdagi O, Shapiro L, Huntley GW, Benson DL, Colman DR: Molecular modification of N-cadherin in response to synaptic activity. Neuron 25: 93-107, 2000

2. Shan W, H Tanaka, Phillips GR, Arndt K, Yoshida M, Colman DR, and Shapiro L: Functional cis-heterodimers of N- and R-cadherins. J Cell Biol 148: 579-590, 2000

3. Taguchi A., Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Stern DM, Schmidt AM: Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405: 354-360, 2000

4. Bozdagi O, Shan W, Tanaka H, Benson DL, Huntley GW: Increasing numbers of synaptic puncta during late-phase LTP: N-cadherin is synthesized, recruited to synaptic sites and required for potentiation. Neuron 28: 245-259, 2000

畑裕（東京医科歯科大学・大学院医歯学総合研究科）

1. Nishimura W, Iizuka T, Hirabayashi S, Tanaka N, Hata Y: Localization of BAP1/MAGI-1 at adherens junctions in NRK cells: the polarized targeting mediated by the carboxyl-terminal PDZ domains. J Cell Physiol 185: 358-365, 2000

2. Deguchi M, Iizuka T, Hata Y, Nishimura W, Hirao K, Yao I, Kawabe H, Takai Y: PAPIN: a novel multiple PDZ protein interacting with neural plakophilin-related armadillo-repeat protein/ß-catenin andp0071. J Biol Chem 275: 29875-29880, 2000

3. Yao I, Ohtsuka T, Kawabe H, Matsuura Y, Takai Y, Hata Y: Association of membrane-associated membrane-associated guanylate kinase-interacting protein-1 with Raf-1. Biochem Biophys Res Commun 270: 538-542, 2000

畠義郎（大阪大学・大学院医学系研究科）

1. Katoh-Semba R, Takeuchi IK, Inaguma Y, Ichisaka S, Hata Y, Tsumoto T, Iwai M, Mikoshiba K, Kato K: Induction of brain-derived neurotrophic factors by convulsant drugs in the rat brain: Involvement of voltage-dependent calcium channels. J Neurochem in press

2. Hata Y, Ohshima M, Ichisaka S, Wakita M, Fukuda M, Tsumoto T: BDNF expands ocular dominance columns in visual cortex in monocularly deprived and non-deprived kittens, but does not in adult cats. J Neurosci 20: RC57, 2000

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