荒井啓行　（東北大学・医学部）

1.Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of Apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease. Dement Geriat Cogn Disord 12: 57-62, 2001

2.Wada H, Nakajoh K, Satoh-Nakagawa T, Suzuki T, Ohrui T, Arai H, Sasaki H: Risk factors of aspiration pneumonia in Alzheimer's disease patients. Gerontology 47: 271-276, 2001

3.Kimura M, Matsushita S, Arai H, Takeda A, Higuchi S: No evidence of association between a dopamine transporter gene polymorphism (1215A/G) and Parkinson's disease. Ann Neurol 49: 276-277, 2001

4.Okamura N, Arai H, Higuchi M, Tashiro M, Matsui T, Hu X-S, Takeda A, Itoh M, Sasaki H: [¹⁸F]FDG-PET study in dementia with Lewy bodies and Alzheimer's disease. Prog Neuro-psychopharmacol Biol Psychiat 25: 447-456, 2001

5.Matsui T, Arai H, Yuzuriha T, Yao H, Miura M, Hashimoto S, Higuchi S, Matsushita S, Morikawa M, Kato A, Sasaki H: Elevated plasma homocysteine levels and a risk of silent brain infarction in elderly people. Stroke 32: 1116-1119, 2000

6.Matsushita S, Arai H, Yuzuriha T, Kato M, Matsui T, Urakami K, Higuchi S: No association between DLST gene and Alzheimer's disease or Wernicke-Korsakoff syndrome. Neurobiol Aging 22: 569-574, 2001

7.Sekine-Aizawa Y, Hama E, Watanabe K, Tsubuki S, Kanai-Azuma M, Kanai Y, Arai H, Aizawa H, Iwata N, Saido CT: Matrix metalloproteinase (MMP) system in brain: identification and characterization of brain-specific MMP highly expressed in cerebellum. Eur J Neurosci 13: 1-15, 2001

8.Matsui T, Morikawa Y, Tojo M, Okamura N, Maruyama M, Hirai H, Chiba H, Matsushita S, Higuchi S, Arai H, Sasaki H: Cathepsin D polymorphism not associated with Alzheimer's disease in Japanese. Ann Neurol 49: 544-545, 2001

9.Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller H-J, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multi-center study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer's disease. Ann Neurol 50: 150-156, 2001

10.Okamura N, Arai H, Maruyama M, Matsui T, Tanji H, Yoshida H, Sugita M, Sasaki H: Serum cholesterol and cerebrospinal fluid amyloid β protein in Alzheimer's disease. J Am Geriat Soc 49: 1738-1739, 2001

11.Takeda M, Tanaka T, Arai H, Sasaki H, Shiji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid1-42 in cerebrospinal fluid as a diagnostic marker for Alzheimer's disease and related disorders: Multi-center study in Japan. Psychogeriatrics 1: 56-63, 2001

12.Yamaya M, Yanai M, Ohrui T, Arai H, Sekizawa K, Sasaki H: Antithrombotic therapy for prevention of pneumonia. J Am Geriat Soc 49: 687-688, 2001

13.Maruyama M, Arai H, Sugita M, Tanji H, Higuchi M, Okamura N, Matsui T, Higuchi S, Matsushita S, Yoshida H, Sasaki H: Cerebrospinal fluid amyloid β1-42 levels in the mild impairment stage of Alzheimer's disease. Exp Neurol 172: 433-436, 2001

14.Suzuki T, Arai H, Iwasaki K, Tanji H, Higuchi M, Okamura N, Matsui T, Maruyama M, Yabe T, Toriizuka K, Yamada H, Hanawa T, Ikarashi Y, Sasaki H: A Japanese herbal medicine (Kami-Untan-To) in the treatment of Alzheimer's disease: A pilot study. Alz Rep 4: 177-182, 2001

15.Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): A comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol 52: 501-509, 2001

16.Tashiro M, Itoh M, Kubota K, Kumano H, Masud MM, Moser EM, Arai H, Sasaki H: Relationship between trait anxiety, brain activity and natural killer cell activity in cancer patients: A preliminary PET study. Psycho-oncology in press

17.Matsushita S, Arai H, Okamura N, Ohmori T, Takasugi K, Matsui T, Maruyama M, Iwatsubo T, Higuchi S: Clinical and bio-marker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild impairment stage of Alzheimer's disease. Biol Psychiat in press

18.Okamura N, Arai H, Maruyama M, Higuchi M, Matsui T, Tanji H, Seki T, Hirai H, Chiba H, Itoh M, Sasaki H: A combined analysis of CSF-tau and IMP-SPECT in mild cognitive impairment: Implications for a novel predictor of Alzheimer's disease. Am J Psychiat in press

新井平伊　（順天堂大学・医学部）

1.Shibata N, Ohnuma T, Takahashi T, Ohtsuka E, Ueki A, Nagao M, Arai H: No genetic association between alpha-2 macroglobulin I1000V polymorphism and Japanese sporadic Alzheimer's disease. Neurosci Lett 290: 154-156, 2000

2.Ishizuka T, Baba H, Higashi S, Arai H: Circulating natural killer cell activity and cytokine production in Alzheimer's disease. Alz Rep 4: 81-85, 2001

3.Ishizuka T, Higashi S, Baba H, Imai K, Eto K, Arai H: The concentrations of serum dehydroepiandrosterone, dehydroepiandrosterone sulfate and cortisol in Japanese sporadic Alzheimer's disease. Alz Rep 4: 205-208, 2001

植木　彰　（自治医科大学・大宮医療センター）

1.Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabita T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiat 6: 83-86, 2001

浦上克哉　（鳥取大学・医学部）

1.Yamagata K, Urakami K, Ikeda K, Ji Y, Adachi Y, Arai H, Sasaki H, Sato K, Nakashima K: High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer’s disease. Dement Geriat Cogn Disord 12: 57-62, 2001

2.Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001.

3.Itoh N, Arai H, Urakami K, Ishiguro K, Ohno H, Hampel H, Buerger K, Wiltfang J, Otto M, Kretzschmar H, Moeller HJ, Imagawa M, Kohno H, Nakashima K, Kuzuhara S, Sasaki H, Imahori K: Large-scale, multicenter study of cerebrospinal fluid tau protein phosphorylated at serine 199 for the antemortem diagnosis of Alzheimer’s disease. Ann Neurol 50: 150-156, 2001

4.Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid(1-42) in cerebrospinal fluid as a diagnostic marker for Alzheimer’s disease and related disorders: Multicenter study in Japan. Psychogeriatrics 1: 56-63, 2001

5.Wakutani Y, Ito T, Wada-Isoe K, Yamagata K, Adachi Y, Taniguchi M, Arai H,　 Sasaki H, Higuchi S, Sato K, Urakami K, Nakashima K: Identification of aberrant tau mRNA in brain tissue. Alz Rep 4: 145-150, 2001

6.Urakami K, Arai H, Itou N, Isiguro K, Oono H, Kohno H, Kuzuhara S, Sasaki H, Imahori K, Nakashima K: CSF tau protein phosphorylated at serine 199 in Alzheimer’s disease -A large scale and multi-center study. World J Biol Psychiat 2: 118S, 2001

7.Yamagata K, Wakutani Y, Urakami K, Wada K, Arai H, Sasaki H, Higuchi S, Sato K, Nakashima K: Apolipoprotein E promoter-186 G/T polymorphism and Japanese Alzheimer’s disease. Alz Rep 4: 161-165, 2001

8.Matsushita S, Arai H, Yuzuriha T, Kato M, Matsui T, Urakami K, Higuchi S: No

9.association between DLST gene and Alzheimer’s disease or Wernicke-Korsakoff syndrome. Neurobiol Aging 22: 569-574, 2001

10.Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging in press

太田成男　（日本医科大学・老人病研究所）

1.Yasukawa T, Suzuki T, Ishii N, Watanabe K, Ohta S: Wobble modification defect in tRNA disturbs codon-anticodon interaction in a mitochondrial disease. EMBO J 20: 4794-4802, 2001

2.Yasukawa T, Suzuki T, Ohta S, Watanabe K: Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion in press

川又敏男　（神戸大学・医学部）

1.Taniguchi T, Kawamata T, Mukai H, Hasegawa H, Isagawa T, Yasuda M, Hashimoto T, Terashima A, Nakai M, Mori H, Ono Y, Tanaka C: Phosphorylation of tau is regulated by PKN. J Biol Chem 276: 10025-10031, 2001

2.Nakai M, Tanimukai S, Yagi K, Saito N, Taniguchi T, Terashima A, Kawamata T, Yamamoto H, Fukunaga K, Miyamoto E, Tanaka C: Amyloid beta protein activates PKC-delta and induces translocation of myristoylated alanine-rich C kinase substrate (MARCKS) in microglia. Neurochem Int 38: 593-600, 2001

3.Hasegawa H, Nakai M, Tanimukai S, Taniguchi T, Terashima A, Kawamata T, Fukunaga K, Miyamoto E, Misaki K, Mukai H, Tanaka C: Microglial signaling by amyloid β protein through mitogen-activated protein kinase mediating phosphorylation of MARCKS. NeuroReport 12: 2567-2571, 2001

4.Tanimukai S, Hasegawa H, Nakai M, Yagi K, Hirai M, Saito N, Taniguchi N, Terashima A, Yasuda M, Kawamata T, Tanaka C: Nanomolar amyloid Aβ protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells. NeuroReport in press

下方浩史　（国立長寿医療研究センター）

1.Yamada Y, Ando F, Niino N, Shimokata H: Transforming growth factor-beta1 gene polymorphism and bone mineral density. J Am Med Assoc 285: 167-168, 2001

2.Masuda Y, Kuzuya M, Uemura K, Yamamoto R, Endo H, Shimokata H, Iguchi A: The effect of public long-term care insurance plane on care management and care planning in Japanese geriatric hospitals. Arch Gerontol Geriat 32: 167-177, 2001

3.Iwao N, Iwao S, Muller DC, Elahi D, Shimokata H, Andres R: A test of recently proposed BMI standards with respect to old age. Aging 12; 461-469, 2001

4.Tsuzuku S, Shimokata H, Ikegami Y, Yabe K, Wasnich RD: Effects of high versus low-intensity resistance training on bone mineral density in young males. Calcif Tissue Int 68; 342-347, 2001

5.Iwao S, Iwao N, Muller DC, Elahi D, Shimokata H, Andres R: Does waist circumference add to thepredictive power of the body mass index for coronary risk? Obes Res 9: 685-695, 2001

6.Kuzuya M, Ando F, Iguchi A, Shimokata H: Changes in serum lipid levels during a 10-year period in a large Japanese population: A cross-sectional and longitudinal study. Atherosclerosis in press

7.Kajioka T, Tsuzuku S, Shimokata H, Sato Y: Effects of intentional weight cycling in non-obese young women. Metabolism in press

東海林幹夫　（岡山大学・大学院医歯学総合研究科）

1.Shoji M, Kanai M: Cerebrospinal fluid Aβ40 and Aβ42: natural course and clinical usefulness. J Alz Dis 3: 313-321, 2001

2.Shoji M, Kanai M, Matsubara E, Tomidokoro Y, Shizuka M, Ikeda Y, Ikeda M, Harigaya Y, Okamoto K, Hirai S: The levels of cerebrospinal fluid Aβ40 and Aβ42(43) are regulated age-dependently. Neurobiol Aging 22: 209-215, 2001

3.Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG: Age-dependent changes in brain, CSF, and plasma amyloid β protein in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurosci 21: 372-381, 2001

4.Murakami T, Iwatsuki K, Hayashi T, Sato K, Matsubara E, Nagano I, Manabe Y, Shoji M, Abe K: Two Japanese CADASIL families with a R141C mutation in the Notch3 gene. Int Med 40: 1144-1148, 2001

5.Urakami K, Wada K, Arai H, Sasaki H, Kanai M, Shoji M, Ishizu H, Kashihara K, Yamamoto M, Tsuchiya-Ikemoto K, Morimatsu M, Takashima H, Nakagawa M, Kurokawa K, Maruyama H, Kaseda Y, Nakamura S, Hasegawa K, Oono H, Hikasa C, Ikeda K, Yamagata K, Wakutani Y, Takeshima T, Nakashima K: Diagnostic significance of tau protein in cerebrospinal fluid from patients with corticobasal degeneration or progressive supranuclear palsy. J Neurol Sci 183: 95-98, 2001

6.Takeda M, Tanaka T, Arai H, Sasaki H, Shoji M, Okamoto K, Urakami K, Nakashima K, Matsubayashi T, Sugita M, Yoshida H: Basic and clinical studies on the measurement of β-amyloid(1-42) in cerebrospinal fluid as a diagnositic marker for Alzheimer’s disease and related disorders: multi center study in Japan. Psychogeriatrics 1: 56-63, 2001

7.Dobrogowska DH, Vorbrodt AW, Wegiel J, Wang KC, Shoji M, Mondadori C, Polatis G, Giovanni A, Wisniewski HM: Cytochemical study of the involvement of cell organelles in formation and accumulation of fibrillar amyloid in the pancreas of NORbeta transgenic mice. Histol Histopathol 16: 1047-1056, 2001

8.Manabe Y, Warita H, Murakami T, Shiote M, Hayashi T, Nagano I, Shoji M, Abe K: Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene. Brain Res 915: 104-107, 2001

9.Manabe Y, Wang JM, Murakami T, Warita H, Hayashi T, Shoji M, Abe K: Expressions of nitrotyrosine and TUNEL immunoreactivities in cultured rat spinal cord neurons after exposure to glutamate, nitric oxide, or peroxynitrite. J Neurosci Res 65: 371-377, 2001

10.Paganelli AR, Ocana OH, Prat MI, Franco PG, Lopez SL, Morelli L, Adamo AM, Riccomagno MM, Matsubara E, Shoji M, Affranchino JL, Castano EM, Carrasco AE: The Alzheimer-related gene presenilin-1 facilitates sonic hedgehog expression in Xenopus primary neurogenesis. Mech Dev 107: 119-131, 2001

11.Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M: Brain Aβ amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. J Pathol 194: 500-506, 2001

12.Tomidokoro Y, Ishiguro K, Harigaya Y, Matsubara E, Ikeda M, Park JM, Yasutake K, Kawarabayashi T, Okamoto K, Shoji M: Abeta amyloidosis induces the initial stage of tau accumulation in APP(Sw) mice. Neurosci Lett 299: 169-172, 2001

13.Manabe Y, Murakami T, Iwatsuki K, Narai H, Warita H, Hayashi T, Shoji M, Imai Y, Abe K: Nocturnal blood pressure dip in CADASIL. J Neurol Sci 193: 13-16, 2001

14.Murakami T, Nagano I, Hayashi T, Manabe Y, Shoji M, Setoguchi Y, Abe K: Impaired retrograde axonal transport of adenovirus-mediated E. coli LacZ gene in the mice carrying mutant SOD1 gene. Neurosci Lett 308: 149-152, 2001

15.Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe W, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ich K, Yoshida H, Toji, H Nakamura S, Hirai H: Cerebrospinal fluid tau in dementia disorders: A large scale multicenter study by a Japanese study group. Neurobiol Aging in press

16.Wahrle S, Kawarabayashi T, McLendon C, Das P, Nyborg AC, Shoji M, Younkin LH, Younkin SG Golde TE: Cholesterol dependent γ-secretase activity in a lipid raft microdomain. Neurobiol Dis in press

南光進一郎　（帝京大学・医学部）

1.Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S: A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiat 6: 83-86, 2001

前田　潔　（神戸大学・大学院医学系研究科）

1.Yamamoto Y, Sengo M, Yasuda M, Maeda K: No association between presenilin 1 intron gene or butyrylcholinesterase K variant and Alzheimer’s disease in Japanese populations. Psychogeriatrics 1: 108-118, 2001

2.Ono H, Shirakawa O, Nishiguchi N, Nishimura A, Nushida H, Ueno Y, Maeda K: Serotonin 2A receptor gene polymorphism is not associated with completed suicide. J Psychiat Res 35: 169-172, 2001

3.Nishiguchi N, Shirakawa O, Ono H, Nishimura A, Nushida H, Ueno Y, Maeda K: No evidence of an association nbetween 5HT1B receptor gene polymorphisim and suicide victims in a Japanese population. Am J Med Genet 105: 343-345, 2001

4.Shirakawa O, Kitamura N, Lin X-H, Hashimoto T, Maeda K: Abnormal neurochemical asymmetry in the temporal lobe of schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiat 25: 867-877, 2001