井原康夫（東京大学・大学院医学系研究科）

1.Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, lhara Y: Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid ß-protein 42 in Chinese hamster ovary cells. Biochemistry 42: 1042-1052, 2003

2.Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y: Potential link between amyloid ß-protein 42 and C-terminal fragment γ49-99 of ß-amyloid precursor protein. J Biol Chem 278: 24294-24301, 2003

3.Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S: Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 22: 2913-2923, 2003

4.Wada S, Morishima-Kawashima M, Qi Y, Misono H, Shimada Y, Ohno-Iwashita Y, Ihara Y: γ-Secretase activity is present in rafts, but not cholesterol-dependent. Biochemistry 42: 13977-13986, 2003

田平　武（国立長寿医療センター研究所）

1.Konagaya M, Kato T, Sakai M, Kuru S, Matsuoka Y, Konagaya Y, Hashizume Y, Tabira T: A clinical and pathological study of a Japanese case of amyotrophic lateral sclerosis/parkinsonism-dementia complex with family history. J Neurol 250: 164-170, 2003

2.Kowalska A, Konagaya M, Sakai M, Hashizume Y, Tabira T: Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex-tauopathy without mutations in the tau gene? Folia Neuropathol 41: 59-64, 2003

3.Santa Y, Uyama E, Chui DH, Arima M, Kotorii S, Takahashi K, Tabira T: Genetic, clinical and pathological studies of CADASIL in Japan: a partial contribution of Notch3 mutations and implications of smooth muscle cell degeneration for the pathogenesis. J Neurol Sci 212: 79-84, 2003

4.Watanabe Y, Tsujimura A, Tabira T, Hashimoto-Gotoh T: Differential expression of presenilin-α and -ß (PSα and PSß) in Xenopus laevis : embryonic phosphorylation of PSα. Gene 314: 165-172, 2003

5.Hashimoto-Gotoh T, Tsujimura A, Watanabe Y, Iwabe N, Miyata T, Tabira T: A unifying model for functional difference and redundancy of presenilin-1 and -2 in cell apoptosis and differentiation. Gene 323: 115-123, 2003

6.Tanahashi H, Asada T, Tabira T: Association between tau polymorphism and male early-onset Alzheimer’s disease. NeuroReport 15: 175-180, 2004

7.Takeda K, Araki W, Tabira T: Enhanced generation of intracellular Aß42 amyloid peptide by mutation of presenilins PS1 and PS2. Eur J Neurosci 19: 258-264, 2004

柳澤勝彦（国立長寿医療センター研究所）

1. Zou K, Kim D, Kakio A, Byun K, Gong J, Kim M, Sawamura N, Nishimoto S, Matsuzaki K, Lee B, Yanagisawa K, Michikawa M: Amyloid ß-protein (Aß)1-40 protects neurons from damage induced by Aß1-42 in culture and in rat brain. J Neurochem 87: 609-619, 2003

2.Sai X, Kokame K, Shiraishi H, Kawamura Y, Miyata T, Yanagisawa K, Komano H: The ubiquitin-like domain of Herp is involved in Herp degradation, but not necessary for its enhancement of amyloid ß–protein generation. FEBS Lett 553: 151-156, 2003

3.Sawamura N, Ko M, Yu W, Zou K, Hanada K, Suzuki T, Gong J, Yanagisawa K, Michikawa M: Modulation of amyloid precursor protein cleavage by cellular sphingolipid. J Biol Chem in press

4.Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid ß-protein. J Neurochem in press

石浦章一（東京大学・大学院総合文化研究科）

1.Kino Y, Oma Y, Takeshita Y, Takahashi N, Sasagawa N, Ishiura S: Direct evidence that EXP/muscleblind interacts with CCUG tetranucleotide repeats. Basic Appl Myol 13: 293-298, 2003

2.Takeshita Y, Sasagawa N, Usuki F, Ishiura S: Decreased expression of alpha-B-crystallin in C2C12 cells that express human DMPK/160CTG repeats. Basic Appl Myol 13: 305-308, 2003

3.Yoshikawa A, Mitsuhashi H, Sasagawa N, Tsukahara T, Hayashi Y, Nishino I, Goto Y, Ishiura S: Expression of ARPP-16/19 in rat denervated skeletal muscle. J Biochem 134: 57-61, 2003

4.Sato T, Dohmae N, Qi Y, Kakuda N, Misonou H, Mitsumori R, Maruyama H, Koo EH, Haass C, Takio K, Morishima-Kawashima M, Ishiura S, Ihara Y: Potential link between amyloid ß-protein 42 and C-terminal fragment γ49-99 of ß-amyloid precursor protein. J Biol Chem 278: 24294-24301, 2003

5.Suo S, Sasagawa N, Ishiura S: Cloning and characterization of a C. elegans D2-like dopamine receptor. J Neurochem 86: 869-878, 2003

6.Sasagawa N, Kino Y, Takeshita Y, Oma Y, Ishiura S: Overexpression of human myotonic dystrophy protein kinase in Saccharomyces Pombe induces abnormal polarized and swollen cell morphology. J Biochem 134: 537-542, 2003

7.Shuto D, Kasai S, Kimura T, Liu P, Hidaka K, Hamada T, Shibakawa S, Hayashi Y, Hattori C, Szabo B, Ishiura S, Kiso Y: KMI-008, a novel beta-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: Design and synthesis of substrate-based octapeptides. Bioorg Med Chem Lett 13: 4273-4276, 2003

8.Asai M, Hattori C, Szabo B, Sasagawa N, Maruyama K, Tanuma S, Ishiura S: Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase. Biochem Biophys Res Commun 301: 231-235, 2003

9.Kino Y, Oma Y, Sasagawa N, Ishiura S: Muscleblind protein, MBNL1/EXP, binds specifically to CHHG repeats. Hum Mol Genet 13: 495-507, 2004

10.Kinouchi T, Ishiura S, Mabuchi Y, Urakami-Manaka Y, Nishio H, Nishiuchi Y, Tsunemi M, Takeda K, Watanabe M, Ikeda M, Matsui H, Tomioka S, Kawahara H, Hamamoto T, Suzuki K, Kagawa Y: Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging. Biochem Biophys Res Commun 314: 730-736, 2004

11.Ito N, Nomura S, Iwase A, Ito T, Kikkawa F, Tsujimoto M, Ishiura S, Mizutani S: ADAMs, a disintegrin metalloproteinases, mediate shedding of oxytocinase. Biochem Biophys Res Commun 314: 1008-1013, 2004

12.Oma Y, Kino Y, Sasagawa N, Ishiura S: Intracellular localization of homopolymeric amino acid-containing proteins expressed in mammalian cells. J Biol Chem in press

13.Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett in press

高島明彦（理化学研究所・脳科学総合研究センター）

1.Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H: Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100: 721-726, 2003

2.Kwok JBJ, Halliday GM, Brook WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vick J, Eang R, Naslund J, Takashima A, Gandy SE, Schofield PR: Presenilin-1 mutation (Leu271Val) results in altered exonic splicing and Alzheimer’s disease with non-cored plaques and neuritic dystrophy. J Biol Chem 278, 6748-54, 2003

3.Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M: Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87, 172-181, 2003

4.Marambaud P, Wen PH, Dutt A, Shioi J, Takashima A, Siman R, Robakis NK: A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations. Cell 114: 635-645, 2003

5.Yoshiike Y, Chui DH, Akagi T, Tanaka N, Takashima A: Specific compositions of amyloid-ß peptides as the determinant of toxic beta-aggregation. J Biol Chem 278: 23648-23655, 2003

6.Kimura N, Tanemura K, Nakamura S, Takashima A, Ono F, Sakakibara I, Ishii Y, Kyuwa S, Yoshikawa Y: Age-related changes of Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Commun 310: 303-311, 2003

7.Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Aiso S, Takashima A, Nishimoto I: Amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through distinct toxic mechanisms: Study of 27 different presenilin 1 mutants. J. Neurosci Res 75 : 417-428, 2004

8.Planel E, Miyasaka T, Launey T, Chui DH, Tanemura K, Sato S, Murayama O, Ishiguro K, Tatebayashi Y, Takashima A: Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation: mechanism and implications for Alzheimer's disease. J Neurosci in press

西道隆臣（理化学研究所・脳科学総合研究センター）

1.Zhang J, Miyamoto K, Hashioka S, Hao PH, Murao K, Saido TC, Nakanishi H: Activation of μ-calpain in developing cortical neurons following methylmercury treatment. Dev Brain Res 142: 105-110, 2003

2.Yokota M, Saido TC, Kamitani H, Tabuchi S, Satokata I, Watanabe T: Calpain induces proteolysis of neuronal cytoskeleton in ischemic gerbil forebrain. Brain Res 984: 122-132, 2003

3.Dare E, Tofighi R, Vettoria MV, Momoi T, Poli D, Saido TC, Mutti A, Ceccatelli S: Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Res 933: 12-22, 2003

4.Wang DS, Iwata N, Hama E, Saido TC, Dickson DW: Oxidized neprilysin in aging and Alzheimer’s disease brains. Biochem Biophys Res Commun 310: 236-241, 2003

5.Porn-Ares MI, Saido TC, Andersson T, Ares MPS: Oxidized low-density lipoprotein induces calpain-dependent cell death and ubiquitination of caspase 3 in HMEC-1 endothelial cells. Biochem J 374: 403-411, 2003

6.Yamashima T, Tonchev AB, Tsukada T, Saido TC, Imajoh-Ohmi S, Momoi T, Kominami E: Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus 13: 791-800, 2003

7.Rami A, Volkmann T, Agarwal R, Schoninger S, Nurnberger F, Saido TC, Winckler J: ß2-adrenergic receptor responsiveness if the calpain-calpastatin system and attenuation of neuronal death in rat hippocampus after transient global ischemia. Neurosci Res 47: 373-382, 2003

8.Inoue H, Tsukita K, Iwasato T, Suzuki Y, Tomioka M, Tateno M, Nagao M, Kawata A, Saido TC, Miura M, Misawa H, Itohara S, Takahashi R: The crucial role of caspase-9 in the disease progression of a transgenic ALS mouse model. EMBO J 22: 6665-6674, 2003

9.Kimura Y, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004

10.Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC: Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-ß peptide in mouse brain. J Neurosci 24: 991-998, 2004

11.Wakutani Y, Watanabe K, Adachi Y, Wada-Isoe K, Urakami K, Ninomiya H, Saido TC, Hashimoto T, Iwatsubo T, Nakashima K: Novel amyloid precursor protein missense mutation in probable Alzheimer’s disease. J Neurol Neurosurg Psychiat in press

西村正樹（滋賀医科大学・分子神経科学研究センター）

1.Wang HQ, Takebayashi K, Tsuchida K, Nishimura M, Noda Y: Follistatin-related gene (FLRG) expression in human endometrium: sex steroid hormones regulate the expression of FLRG in cultured human endometrial stromal cells. J Clin Endocrinol Metab 88: 4432-4439, 2003

森　啓（大阪市立大学・大学院医学研究科）

1.Takuma H, Arawaka S, Mori H: Isoforms changes of tau protein during development in various species. Dev Brain Res 142: 121-127, 2003

2.Minami M, Mizutanib T, Kawanishi R, Suzuki Y, Mori H: Neuronal expression of αB crystallin in cerebral infarction. Acta Neuropathol 105: 549–554, 2003

3.Mori H., Tomiyama T, Maeda N, Ozawa K, Wakasa K: Lack of amyloid plaque formation in the central nervous system of a patient with Werner syndrome. Neuropathology 23: 51-56, 2003

4.Hebert SS, Godin C, Tomiyama T, Mori H, Levesque G: Dimerization of presenilin-1 in vivo: suggestion of novel regulatory mechanisms leading to higher order complexes. Biochem Biophys Res Commun 301: 119-126, 2003

5.Kametani F, Usami M, Tanaka K, Kume H, Mori H: Mutant presenilin (A260V) affects Rab8 in PC12D cell. Neurochem Int 44: 313-320, 2003

6.Kanemitsu H, Tomiyama T, Mori H: Human neprilysin is capable of degrading amyloid ß peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci Lett 350: 113–116, 2003

7.Uchihara T, Nakamura A, Nakayama H, Arima K, Ishizuka N, Mori H, Mizushima S: Triple immunofluorolabeling with two rabbit polyclonal antibodies and a mouse monoclonal antibody allowing three-dimensional analysis of cotton wool plaques in Alzheimer disease. J Hisochem Cytochem 51: 1201-1206, 2003

8.Takuma H, Tomiyama T, Kuida K, Mori H: Amyloid ß peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo . J Neuropathol Exp Neurol 63: 255-261, 2003

9.Ataka S, Tomiyama T, Takuma H, Yamashita T, Shimada T, Tsutada T, Kawabata K, Mori H, Miki T: A novel presenilin-1 mutation (Leu85Pro) in early-onset AD with spastic paraparesis. Arch Neurol in press

荒若繁樹（山形大学医学部・生命情報内科学）

1.Kikuchi K, Arawaka S, Koyama S, Kimura H, Ren CH, Wada M, Kawanami T, Kurita K, Daimon M, Kawakatsu S, Kadoya T, Goto K, Kato T: An N-terminal fragment of ProSAAS (a granin-like neuroendocrine peptide precursor) is associated with tau inclusions in Pick's disease. Biochem Biophys Res Commun 308: 646-654, 2003

2.Chen F, Tandon A, Sanjo N, Gu YJ, Hasegawa H, Arawaka S, Lee FJ, Ruan X, Mastrangelo P, Erdebil S, Wang L, Westaway D, Mount HT, Yankner B, Fraser PE, St George-Hyslop P: Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain. J Biol Chem 278: 19974-19979, 2003

3.Wada M, Ren CH, Koyama S, Arawaka S, Kawakatsu S, Kimura H, Nagasawa H, Kawanami T, Kurita K, Daimon M, Hirano A, Kato T: A human granin-like neuroendocrine peptide precursor (proSAAS) immunoreactivity in tau inclusions of Alzheimer's disease and parkinsonism-dementia complex on Guam. Neurosci Lett 356: 49-52, 2004

池田将樹（群馬大学・大学院医学系研究科）

1.Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging in press

2.Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M, Soluble Aß homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging in press

伊藤仁一（名古屋市立大学・大学院医学系研究科）

1.Tada T, Ito J, Asai M, Yokoyama S: Fibroblast growth factor 1 is produced prior to apolipoprotein E in the astrocytes after cryo-injury of mouse brain. Neurochem Int in press

大河内正康（大阪大学・大学院医学系研究科）

1.Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C. Identification of a ß-secretase activity, which truncates amyloid ß-peptide after its presenilin-dependent generation. J Biol Chem 278: 5531-5538, 2003

小野正博（長崎大学・大学院医歯薬学総合研究科）

1.Ono M, Wilson A, Nobrega J, Westaway D, Verhoeff P, Zhuang ZP, Kung MP, Kung HF: ¹¹C-labeled stilbene derivatives as Aß-aggregate-specific PET imaging agents for Alzheimer’s disease. Nucl Med Biol 30: 565-571, 2003

菅　敏幸（東京大学・大学院薬学系研究科）

1.Kurosawa W, Kan T, Fukuyama T: An efficient synthesis of optically active trans -2-aryl-2,3-dihydrobenzofuran-3-carboxylic acid esters via C-H insertion reaction. Synlett 1028-1030, 2003

2.Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide is a non-competitive γ-secretase inhibitor that preferentially reduces Aß42 generation. J Biol Chem 278: 18664-18673, 2003

3.Kurosawa W, Kan T, Fukuyama T: Stereocontrolled total synthesis of (–)-ephedradine A (Orantine). J Am Chem Soc 125: 8112-8113, 2003

4.Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: Highly efficient incorporation of biotin-tag and cross-linking group. Chem Commun 2244-2245, 2003

5.Kan T: Total synthesis of potent antitumor alkaloid ecteinascidin 743. J Syn Org Chem Jpn 61: 949-960, 2003

6.Rikimaru K, Yanagisawa A, Kan T, Fukuyama T: A versatile synthesis of α-amino acid derivatives via the Ugi four-component condensation with a novel convertible isonitrile. Synlett 41-43, 2004

7.Kan T, Fukuyama T: Ns Strategies: A highly versatile synthetic method for amines. Chem Commun 353-359, 2004

8.Kurosawa W, Kobayashi H, Kan T, Fukuyama T: Total synthesis of (–)-ephedradine A (Orantine): An efficient construction of optically active dihydrobenzofuran-ring via C-H insertion reaction. Tetrahedron Lett in press

9.Tohma S, Rikimaru K, Endo A, Kan T, T. Fukuyama T: Stereoselective nucleophilic addition reaction with a new chiral template and its application to synthesis of optically active α-arylglycine derivatives. Synthesis in press

10.Fuwa H, Okamura Y, Morohashi Y, Tomita T, Iwatsubo T, Kan T, Fukuyama T Natsuari H: Highly efficient synthesis of medium-sized lactams via intramolecular Staudinger-aza-Wittig reaction of ω-azide pentaphenyl ester: synthesis and biological evaluation of LY411575 analogues. Tetrahedron Lett in press

11.Kan T, Tominari Y, Rikimaru K, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, T. Fukuyama T, Parallel synthesis of DAPT derivatives and their γ-secretase-inhibitory activity. Bioorg Med Chem Lett in press

木曽良明（京都薬科大学・薬学部）

1.Hamada Y, Matsumoto H, Kimura T, Hayashi Y, Kiso Y: Effect of the acyl groups on O→N acyl migration in the water-soluble prodrugs of HIV-1 protease inhibitor. Biorg Med Chem Lett 13: 2727-2730, 2003

2.Nezami A, Kimura T, Hidaka K, Kiso A, Liu J, Kiso Y, Goldberg DE, Freire E: High affinity inhibition of a family of Plasmodium falciparum proteases by a designed adaptive inhibitor. Biochemistry 42: 8459-8464, 2003

3.Kiso Y, Kasai S, Shuto D, Liu P, Rajesh S, Kotake T, Hidaka K, Hamada T, Shibakawa S, Kimura T, Hayashi Y: Design and synthesis of substrate-based ß-secretase inhibitors. Biopolymers 71: 290, 2003

4.Hayashi Y, Skwarczynski M, Hamada Y, Sohma Y, Kimura T, Kiso Y: A novel approach of water-soluble paclitaxel prodrug with no auxiliary and no byproduct: Design and synthesis of isotaxel. J Med Chem 46: 3782-3784, 2003

5.Sohma Y, Hayashi Y, Ito T, Matsumoto H, Kimura T, Kiso Y: Development of water-soluble prodrugs of the HIV-1 protease inhibitor KNI-727: Importance of the conversion time for higher gastrointestinal absorption of prodrugs based on spontaneous chemical cleavage. J Med Chem 46: 4124-4135, 2003

6.Shuto D, Kasai S, Kimura T, Liu P, Hidaka K, Hamada T, Shibakawa S, Hayashi Y, Hattori C, Szabo B, Ishiura S, Kiso Y: KMI-008, a novel ß-secretase inhibitor containing a hydroxymethylcarbonyl isostere as a transition-state mimic: design and synthesis of substrate-based octapeptides. Bioorg Med Chem Lett 13: 4273-4276, 2003

7.Skwarczynski M, Sohma Y, Kimura M, Hayashi Y, Kimura T, Kiso Y: O-N Intramolecular acyl migration strategy in water-soluble prodrugs of taxoids. Bioorg Med Chem Lett 13: 4441-4444, 2003

8.Sohma Y, Sasaki M, Hayashi Y, Kimura T, Kiso Y: Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O -acyl isopeptides. Chem Commun 124-125, 2004

9.Hamada Y, Matsumoto H, Yamaguchi S, Kimura T, Hayashi Y, Kiso Y: Water-soluble prodrugs of dipeptide HIV protease inhibitors based on O-N intramolelcular acyl migration: design, synthesis and kinetic study. Bioorg Med Chem 12: 159-170, 2004

10.Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y. KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004

11.Kotake T, Rajesh SN, Hayashi Y, Mukai Y, Ueda M, Kimura T, Kiso Y:A new polymer-supported Evans-type chiral auxiliary derived from α-hydroxy-ß-amino acid, phenylnorstatine: Synthesis and application in solid-phase asymmetric alkylation reactions. Tetrahedron Lett in press

下濱　俊（京都大学・大学院医学研究科）

1.Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishi N: The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. J Biol Chem 278: 12130-12134, 2003

2.Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S: Phosphodiesterase (PDE) inhibitors are neuroprotective to cultured motor neurons. J Neurosci Res 71: 485-495, 2003

3.Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S: Hyperbilirubinemia protects against focal ischemia in rats. J Neurosci Res 71: 544-550, 2003

4.Takata K, Kitamura Y, kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S: Role of high mobility group protein-1 (HMG1) in amyloid-ß homeostasis. Biochem Biophys Res Commun 301, 699-703, 2003

5.Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S: Involvement of WAVE and Rac1 in the phagocytosis of amyloid-β(1-42) in rat microglia. J Pharmacol Sci 92: 115-123, 2003

6.Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Shimohama S: Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling. J Neurosci Res 73: 166-175, 2003

7.Kitamura Y, Tsuchiya D, Takata K, Shibagaki K, Taniguchi T, Smith MA, Perry G, Miki H, Takenawa T, Shimohama S: Possible involvement of Wiskott-Aldrich syndrome protein (WASP) family in aberrant neuronal sprouting in Alzheimer,s disease. Neurosci Lett 346: 149-152, 2003

8.Kitamura Y, Inden M, Sanada H, Takata K, Taniguchi T, Shimohama S, Orii H, Mochii M, Agata K, Watanabe K: Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model. J Pharmacol Sci 92: 137-142, 2003

9.Takata K, Kitamura Y, Umeki M, Tsuchiya D, Kakimura J, Taniguchi T, Gebicke-Haerter PJ, Shimohama S: Possible involvement of small oligomers of amyloid-b peptides in 15-deoxy-⊿^12,14 prostaglandin J₂-sensitive microglial activation. J Pharmacol Sci 91: 330-333, 2003

10.Hitomi T, Mezaki T, Tsujii T, Kinoshita M, Tomimoto H, Ikeda A, Shimohama S, Okazaki T, Uchiyama T, Shibasaki H: Improvement of central motor conduction after bone marrow transplantation in adrenoleukodystrophy. J Neurol Neurosurg Psychiat 74: 373-375, 2003

11.Takata K, Kitamura Y, Tsuchiya D, Kawasaki T, Taniguchi T, Shimohama S: Heat shock protein-90-induced microglial clearance of exogenous amyloid-ß_1-42 in rat hippocampus in vivo. Neurosci Lett 344: 87-90, 2003

12.Uemura K, Kitagawa N, Kohno R, Kuzuya A, Kageyama T, Chonabayashi K, Shibasaki H, Shimohama S: Presenilin 1 is involved in the maturation and trafficking of N-cadherin to the plasma membrane. J Neurosci Res 74: 184-191, 2003

13.Nagasawa K, Tanino H, Shimohama S, Fijimoto S: Effects of hypoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain. Life Sci 73: 1453-1462, 2003

14.Sakka N, Sawada H, Izumi Y, Kume T, Katsuki H, Kaneko S, Shimohama S, Akaike A: Dopamine is involved in selectivityof dopaminergic neuronal death by rotenone. NeuroReport 14: 2425-2428, 2003

15.Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y: Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochem Res 28: 1035-1040, 2003

16.Sawada H, Kohno R, Kihara T, Izumi Y, Sakka N, Ibi M, Nakanishi M, Nakamizo T, Yamakawa K, Shibasaki H, Yamamoto N, Akaike A, Inden M, Kitamura Y, Taniguchi T, Shimohama S: Proteasome mediates dopaminergic neuronal degeneration and its inhibition causes α-synuclein inclusions. J Biol Chem in press

17.Shiozaki A, Tsuji T, Kohno R, Kawamata J, Uemura K, Teraoka H, Shimohama S: Proteome analysis of brain proteins in Alzheimer,s disease: Subproteomics following sequentially extracted protein preparation. J Alz Dis in press

18.Inden M, Kondo J, Kitamura Y, Takata K, Tsuchiya D, Nishimura K, Taniguchi T, Sawada H, Shimohama S: Differences in rotational asymmetry in rats caused by single intranigral injections of 6-hydroxydopamine, 1-methyl-4-phenylpyridinium ion and rotenone. Biog Amines in press

19.Kihara T, Shimohama S: Alzheimer’s disease and acetylcholine receptors. Acta Neurobiol Exp in press

鈴木利治（北海道大学・大学院薬学研究科）

1.Inomata H, Nakamura Y, Hayakawa A, Takata H, Suzuki T, Miyazawa K, Kitamura N: A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1. J Biol Chem 278: 22946-22955, 2003

2.Sumioka A, Imoto S, Martins R N, Kirino Y, Suzuki T: XB51 isoforms mediate Alzheimer’s ß-amyloid peptide production by X11L-dependent and –independent mechanisms. Biochem J 374: 261-268, 2003

3.Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein mediated stabilization of amyloid ß-protein precursor metabolism. J Biol Chem 278: 49448-49458, 2003

4.Sawamura N, Mihee K, Wenxin Y, Zou K, Handa K, Suzuki T, Gong J-S, Yanagisawa K, Michikawa M: Modulation of amyloid precursor protein cleavage by cellular sphingolipids. J Biol Chem in press

5.Taru H, Suzuki T: Facilitation of stress-induced phosphorylation of ß-amyloid precursor protein family members by X11-like/Mint2 protein. J Biol Chem in press

玉岡　晃（筑波大学・臨床医学系）

1.Ishii K, Tamaoka A, Matsuno S, Shoji S: Isolated peroneal nerve palsy complicating weight loss due to anterior pituitary hypofunction. Eur J Neurol 10: 187-188, 2003

2.Ishii K, Tokuda T, Matsushima T, Miya F, Shoji S, Ikeda S, Tamaoka A: Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-ß (Aß) 40 or Aß 42 in humans. Neurosci Lett 350:161-164, 2003

3.Ishii K, Tamaoka A, Shoji S: MRI of idiopathic lumbosacral plexopathy. Neurology in press

玉村啓和（京都大学・大学院薬学研究科）

1.Tamamura H, Kato T, Otaka A, Fujii N: Synthesis of potent ß-secretase inhibitors containing a hydroxyethylamine dipeptide isostere and their structure-activity relationship studies. Org Biomol Chem 1: 2468-2473, 2003

2.Otaka A, Yukimasa A, Watanabe J, Sasaki Y, Oishi S, Tamamura H, Fujii N: Application of samarium diiodide (SmI₂)-induced reduction of γ-acetoxy-α,β-enoates with α-specific kinetic electrophilic trapping for the synthesis of amino acid derivatives. Chem Commun 15: 1834-1835, 2003

3.Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N: Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multi-drug resistant HIV-1 strains. J Med Chem 46: 1764-1768, 2003

4.Tamamura H, Hori A, Kanzaki N, Hiramatsu K, Mizumoto M, Nakashima H, Yamamoto N, Otaka A, Fujii N: T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer. FEBS Lett 550: 79-83, 2003

5.Trent JO, Wang Z, Murray JL, Shao W, Tamamura H, Fujii N, Peiper SC: Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists. J Biol Chem 278: 47136-47144, 2003

6.Tamamura H, Sigano DM, Lewin NE, Blumberg PM, Marquez VE: Conformationally constrained analogues of diacylglycerol. 20. The search for an elusive binding site on protein kinase C (PK-C) through relocation of the carbonyl pharmacophore along the sn -1 side chain of DAG-lactones. J Med Chem 47: 644-655, 2004

7.Tamamura H, Mizumoto M, Hiramatsu K, Kusano S, Terakubo S, Yamamoto N, Trent JO, Wang Z, Peiper SC, Nakashima H, Otaka A, Fujii N: Topochemical exploration of potent compounds using retro-enantiomer libraries of cyclic pentapeptides. Org Biomol Chem in press

出澤真理（京都大学・大学院医学研究科）

1.Yamada H, Dezawa M, Shimazu S, Baba M, Sawada H, Kuroiwa Y, Yamamoto I, Kanno H: Transfer of the von Hippel-Lindau gene to neuronal progenitor cells in treatment for Parkinson's disease. Ann Neurol 54: 352-359, 2003

2.Ohmura M, Ogawa T, Ono M, Dezawa M, Hosaka M, Kubota Y, Sawada H: Increment of murine spermatogonial cell number by gonadotropin-releasing hormone analogue is independent of stem cell factor - c-kit signal. Biol Reprod 68: 2304-2313, 2003

3.Takano Y, Ohguro H, Dezawa M, Ishikawa H, Yamazaki H, Ohguro I, Mamiya K, Metoki T, Ishikawa F, Nakazawa M: Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochem Biophys Res Commun 313: 1015-1022, 2004

4.Ishikawa H, Takano M, Matsumoto N, Sawada H, Ide C, Mimura O, Dezawa M: The effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with contact type electrode. Gene Ther in press

5.Ohta M, Suzuki Y, Noda T, Ejiri Y, Dezawa M, Kataoka K, Chou H, Matsumoto N, Iwashita Y, Mizuta E, Kuno S, Ide C: Bone marrow stromal cells infused into the cerebrospinal fluid promote functional recovery of the injured rat spinal cord with reduced cavity formation. Exp Neurol in press

富田泰輔（東京大学・大学院薬学系研究科）

1.Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I: Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol. J Neurosci 23: 8513-8525, 2003

2.Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R: APP processing and synaptic function. Neuron 37: 925-937, 2003

3.Kan T, Tominari Y, Morohashi Y, Natsugari H, Tomita T, Iwatsubo T, Fukuyama T: Solid-phase synthesis of photoaffinity probes: highly efficient incorporation of biotin-tag and cross-linking groups. Chem Commun 17: 2244-2245, 2003

4.Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H: Presenilin-dependent γ-secretase activity mediates the intramembranous cleavage of CD44. Oncogene 22: 1511-1516, 2003

5.Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, Shearman M, Kopan R: A presenilin dimer at the core of the γ-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci USA 100: 13075-13080, 2003

6.Takahashi Y, Hayashi I, Tominari Y, Rikimaru K, Morohashi Y, Kan T, Natsugari H, Fukuyama T, Tomita T, Iwatsubo T: Sulindac sulfide is a noncompetitive γ-secretase inhibitor that preferentially reduces Aß42 generation. J Biol Chem 278: 18664-18670, 2003

7.Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422:438-441, 2003

8.Matsubayashi H, Sese S, Lee JS, Shirakawa T, Iwatsubo T, Tomita T, Yanagawa S: Biochemical characterization of the Drosophila wingless signaling pathway based on RNA interference. Mol Cell Biol 24: 2012-2024, 2004

内木宏延（福井大学・医学部）

1.Ban T, Hamada D, Hasegawa K, Naiki H, Goto Y: Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence. J Biol Chem 278: 16462-16465, 2003

2.Hasegawa K, Ohhashi Y, Yamaguchi I, Takahashi N, Tsutsumi S, Goto Y, Gejyo F, Naiki H: Amyloidogenic synthetic peptides of ß2-microglobulin: a role of the disulfide bond. Biochem Biophys Res Commun 304: 101-106, 2003

3.Yamaguchi I, Suda H, Tsuzuike N, Seto K, Seki M, Yamaguchi Y, Hasegawa K, Takahashi N, Yamamoto S, Gejyo F, Naiki H: Glycosaminoglycan and proteoglycan inhibit the depolymerization of ß2-microglobulin amyloid fibrils in vitro. Kidney Int 64: 1080-1088, 2003

4.Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M: Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer's disease. J Neurochem 87: 172-181, 2003

5.Gozu M, Lee YH, Ohhashi Y, Hoshino M, Naiki H, Goto Y: Conformational dynamics of ß2-microglobulin analyzed by reduction and reoxidation of the disulfide bond. J Biochem 133: 731-736, 2003

6.Chiba T, Hagihara Y, Higurashi T, Hasegawa K, Naiki H, Goto Y: Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of ß2-microglobulin. J Biol Chem 278: 47016-47024, 2003

7.Hirota-Nakaoka N, Hasegawa K, Naiki H, Goto Y: Dissolution of ß2-microglobulin amyloid fibrils by dimethylsulfoxide. J Biochem 134: 159-164, 2003

8.Yamamoto S, Yamaguchi I, Hasegawa K, Tsutsumi S, Goto Y, Gejyo F, Naiki H: Glycosaminoglycans enhance the trifluoroethanol-induced extension of ß₂-microglobulin-related amyloid fibrils at a neutral pH. J Am Soc Nephrol 15: 126-33, 2004

9.Mori I, Yokochi T, Koide N, Sugiyama T, Yoshida T, Kimura Y, Naiki H, Matsubara R, Takeuchi T, Nishiyama Y: PCR search for the herpes simplex virus type 1 genome in brain sections of patients with familial Alzheimer's disease. J Clin Microbiol 42: 936-937, 2004

10.Ono K, Hasegawa K, Naiki H, Yamada M: Curcumin has potent anti-amyloidogenic effects for Alzheimer's ß-amyloid fibrils in vitro . J Neurosci Res 75: 742-750, 2004

11.Ohhashi Y, Hasegawa K, Naiki H, Goto Y: Optimum amyloid fibril formation of a peptide fragment suggests the amyloidogenic preference of ß2-microglobulin under physiological conditions. J Biol Chem in press

12.Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid ß-protein. J Neurochem in press

13.Villanueva J, Hoshino M, Katou H, Kardos J, Hasegawa K, Naiki H, Goto Y: Increase in the conformational flexibility of ß2-microglobulin upon copper binding: A possible role for copper in dialysis-related amyloidosis. Protein Sci in press

14.Yamaguchi K, Katou H, Hoshino M, Hasegawa K, Naiki H, Goto Y: Core and heterogeneity of ß₂-microglobulin amyloid fibrils as revealed by H/D exchange. J Mol Biol in press

橋本康弘（理化学研究所・フロンティア研究システム）

1.Yamaji T, Nakamura K, Amari S, Suzuki A, Hashimoto Y: Application of a multivalent glycoprobe: Charactereization of sugar-binding specificity of siglec family proteins. Meth Enzymol 363: 104-113, 2003

2.Chen N, Furuya S, Doi H, Hashimoto Y, Kudo Y, Higashi H: Ganglioside/Calmodulin kinase II signal inducing cdc-42-mediated neuronal actin reorganization. Neuroscience 120: 163-176, 2003

3.Chen N, Furuya S, Shinoda Y, Yumoto M, Ohtake A, Sato K, Doi H, Hashimoto Y, Kudo Y, Higashi H: Extracellular carbohydrate-signal triggering cAMP-dependent protein kinase-dependent neuronal actin-reorganization. Neuroscience 122: 985-995, 2003

4.Kimura T, Shuto D, Kasai S, Liu P, Hidaka K, Hamada T, Hayashi Y, Hattori C, Asai M, Kitazume S, Saido TC, Ishiura S, Kiso Y: KMI-358 and KMI-370, highly potent and small-sized BACE1 inhibitors containing phenylnorstatine. Bioorg Med Chem Lett 14: 1527-1531, 2004

5.Kitazume S, Saido TC, Hashimoto Y: Alzheimer’s ß-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconj J 20: 59-62, 2004

6.Ichinose I, Hashimoto Y, Kunitake T: Overall wrapping of bio-macromolecules (dextran, amylopectin, and horse heart cytochrome c) with ultrathin silicate layer. Chem Commun in press

長谷川成人（東京都精神医学総合研究所・分子神経生物学）

1.Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology. Ann Neurol 53: 133-137, 2003

2.Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of α-synuclein characteristic of synucleinopathy lesion is recapitulated in α-synuclein transgenic Drosophila. Neurosci Lett 336: 155-158, 2003

3.Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropathol Exp Neurol 62: 644-654, 2003

4.Arai T, Nonaka T, Hasegawa M, Akiyama H, Yoshida M, Hashizume Y, Tsuchiya K, Oda T, Ikeda K: Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. Neurosci Lett 342: 41-44, 2003

5.Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: α-Synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003

6.Taniguchi S, McDonagh AM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathol Appl Neurobiol 30: 1-18, 2004

7.Arai T, Ikeda K, Akiyama H, Nonaka T, Hasegawa M, Ishiguro K, Iritani S, Tsuchiya K, Iseki E, Yagishita S, Oda T, Mochizuki A: Identification of amino-terminal cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degeneration. Ann Neurol 55: 72-79, 2004

8.Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K: Accumulation of phosphorylated a-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol in press

9.Umeda Y, Taniguchi S, Arima K, Piao Y-S, Takahashi H, Iwatsubo T, Mann D, Hasegawa M: Alterations in human tau transcripts correlate with those of neurofilament in sporadic tauopathies. Neurosci Lett in press

10.Sabio G, Reuver S, Feijoo C, Hasegawa M, Thomas GM, Centeno F, Kuhelendahl S, Leal-Ortiz S, Goedert M, Garner C, Cuenda A: Stress- and mitogen-induced phosphorylation of the synapse-associated protein SAP90/PSD95 by activation of SAPK3/p38 and ERK1/ERK2. Biochem J in press

11.Pickering-Brown SM, Baker M, Nonaka T, Ikeda K, Sharma S, Mackenzie J, Simpson SA, Moore JW, Snowden JS, de Silva R, Revesz T, Hasegawa M, Hutton M, Mann DMA: Frontopemporal dementia with Pick-type histology associated with Q336R mutation in tau gene. Brain in press

原田彰宏（群馬大学・生体調節研究所）

1.Hayashi K, Kawai-Hirai R, Harada A, Takata K: Inhibitory neurons from fetal rat cerebral cortex exert delayed axon formation and active migration in vitro. J Cell Sci 116: 4419-4428, 2003

藤野貴広（東北大学・遺伝子実験施設）

1.Magoor K, Kang M-J, Iwazaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim D-H, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui U, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT: Severe hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both low-density lipoprotein receptor-related protein 5 (LRP5) and apolipoprotein E. J Biol Chem 278: 11331-11338, 2003

2.Yamamoto J, Ikeda Y, Iguchi H, Fujino T, Tanaka T, Asaba H, Ioka RX, Iwasaki S, Kaneko I, Takahashi S, Sakaue H, Kodama T, Yanagisawa M, Yamamoto TT, Ito S, Sakai J: A krüppel-like factor KLF 15 mediates fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene, AceCS2. J Biol Chem in press

松崎勝巳（京都大学・大学院薬学研究科）

1.Zou K, Kim D, Kakio A, Byun K, Gong J, Kim M, Sawamura N, Nishimoto S, Matsuzaki K, Lee B, Yanagisawa K, Michikawa M: Amyloid ß-protein (Aß)1–40 protects neurons from damage induced by Aß 1–42 in culture and in rat brain. J Neurochem 87: 609-619, 2003

2.Makino A, Baba T, Fujimoto K, Iwamoto K, Yano Y, Terada N, Ohno, Sato SB, Ohta A, Umeda M, Matsuzaki K, Kobayashi T: Cinnamycin (Ro 09-0198) promotes cell binding andtoxicity by inducing transbilayer lipid movement. J Biol Chem 278: 3204-3209, 2003

3.Kakio A, Yano Y, Takai D, Kuroda Y, Matsumoto O, Kozutsumi Y, Matsuzaki K: Interaction between amyloid b-protein aggregates and membranes. J Pep Sci in press

4.Yamamoto N, Hasegawa K, Matsuzaki K, Naiki H, Yanagisawa K: Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid ß-protein. J Neurochem in press

松原悦朗（岡山大学・大学院医歯学総合研究科）

1.Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. J Neurochem 85: 1101-1108, 2003

2.Pappolla MA, Bryant-Thomas TK, Herbert D, Pacheco J, Fabra Garcia M, Manjon M, Girones X, Henry TL, Matsubara E, Zambon D, Wolozin B, Sano M, Cruz-Sanchez FF, Thal LJ, Petanceska SS, Refolo LM: Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology. Neurology 61: 199-205, 2003

3.Murakami T, Shoji-M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R, Abe K: Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Ann Neurol 55: 439-442, 2004

4.Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25: 483-490, 2004

5.Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aß homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging in press

6.Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric Aß rapidly accumulates in lipid rafts followed by ApoE and phosphorylated tau as memory is impaired in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci in press

7.Kurata T, Matsubara E, Yokayama M, Nagano I, Shoji M, Abe K: Improvement of SSPE by intrathecal infusion of α-IFN. Neurology in press

水口峰之（富山医科薬科大学・薬学部）

1.Mizuguchi M, Kroon GJ, Wright PE, Dyson HJ: Folding of a ß-sheet protein monitored by real-time NMR spectroscopy. J Mol Biol 328: 1161-1171, 2003

2.Sato K, Nakamura T, Mizuguchi M, Miura K, Tada M, Aizawa T, Gomi T, Miyamoto K, Kawano K: Solution structure of epiregulin and the effect of its C-terminal domain for receptor binding affinity. FEBS Lett 553: 232-238, 2003

3.Shinohara Y, Mizuguchi M, Matsubara K, Takeuchi M, Matsuura A, Aoki T, Igarashi K, Terada Y, Kawano K: Biophysical analyses of the transthyretin variants, Tyr114His and Tyr116Ser, associated with familial amyloidotic polyneuropathy. Biochemistry 42: 15053-15060, 2003

4.Kouno T, Mizuguchi M, Tanida I, Ueno T, Kominami K, Kawano K: ¹H, ¹³C and ¹⁵N resonance assignments of human microtubule-associated protein light chain-3. J Biomol NMR in press

村山繁雄（東京都老人総合研究所）

1.Kasahata N, Shiota J, Miyazawa Y, Nakano I, Murayama S: Acute human T-lymphotropic virus type 1 associated myelopathy – clinical and pathological study. Arch Neurol 60: 873-876, 2003

2.Saito Y, Kawashima A, Fujiwara H, Ruberu NN, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropath Exp Neurol 62: 644-654, 2003

3.Takeda Y, Akasaka K, Leww S, Kobayashi S, Kawano H, Murayama S, Takahashi N, Hashimoto K, Kano M, Asano M, Sudo K, Iwakura Y, Watanabe K: Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/ F3 subgroup. J Neurobiol 56: 252-265, 2003

4.Tokumaru AM, Kamakura K, Maki T, Murayama S, Sakata I, Kaji T, Kohyama S, Kusano S, Hasegawa S: Magnetic resonance imaging findings of Machado-Joseph disease: histopathologic correlation. J Comput Assist Tomogr 27: 241-248, 2003

5.Saito Y, Suzuki K, Hulette CM, Murayama S: Aberrant phosphorylation of α-synuclein in human Niemann-Pick type C disease. J Neuropath Exp Neurol in press

山口晴保（群馬大学・医学部）

1.Kokubo H, Helms JB, Ohno-Iwashita Y, Shimada Y, Horikoshi Y, Yamaguchi H: Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res 965: 83-90, 2003

2.Sasaki A, Horikoshi Y, Yokoo H, Nakazato Y, Yamaguchi H: Antiserum against human glucose transporter 5 is highly specific for microglia among cells of the mononuclear phagocyte system. Neurosci Lett 338:17-20, 2003

3.Horikoshi Y, Sasaki A, Taguchi N, Maeda M, Tsukagoshi H, Sato K, Yamaguchi H: Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections. Acta Neuropathol 105: 157-162, 2003

4.Hashimoto N, Takeuchi T, Ishihara R, Ukai K, Kobayashi H, Iwata H, Iwai K, Mizuno Y, Yamaguchi H, Shibayama H: Glial fibrillary tangles in diffuse neurofibrillary tangles with calcification. Acta Neuropathol 106: 150-156, 2003

5.Kanamori T, Nishimaki K, Asoh S, Ishibashi Y, Takata I, Kuwabara T, Taira K, Yamaguchi H, Sugihara S, Yamazaki T, Ihara Y, Nakano K, Matuda S, Ohta S: Truncated product of the bifunctional DLST gene involved in biogenesis of the respiratory chain. EMBO J 22: 2913-2923, 2003

6.Rofina J, van Andel I, van Ederen AM, Papaoiannou N, Yamaguchi H, Gruys E: Canine counterpart of senile dementia of the Alzheimer type: amyloid plaques near capillaries but lack of spatial relationship with activated microglia and macrophages. Amyloid: J Prot Fold Disord 10: 86-96, 2003

7.Araki Y, Tomita S, Yamaguti H, Miyagi N, Sumioka A, Kirino Y, Suzuki T: Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid ß-protein. J Biol Chem 278: 49448-49458, 2003