三品昌美（東京大学・大学院医学系研究科）

1.Takatsuki K, Kawahara S, Kotani S, Fukunaga S, Mori H, Mishina M, Kirino Y: The hippocampus plays an important role in eyeblink conditioning with a short trace interval in glutamate receptor subunit δ2 mutant mice. J Neurosci 23: 17-22, 2003

2.Townsend M, Yoshii A, Mishina M, Constantine-Paton M: Developmental loss of miniature N -methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci USA 100: 1340-1345, 2003

3.Fagiolini M, Katagiri H, Miyamoto H, Grant S G N, Mishina M, Hensch T: Separable features of visual cortical plasticity revealed by N -methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci USA 100: 2854-2859, 2003

4.Brickley S G, Misra C, Mok M H S, Mishina M, Cull-Candy S G: NR2B and NR2D subunits co-assemble in cerebellar Golgi cells to form a distinct NMDAR subtype restricted to extrasynaptic sites. J Neurosci 23: 4958-4966, 2003

5.Okada H, Miyakawa N, Mori H, Mishina M, Miyamoto Y, Hisatsune T: NMDA receptors in cortical development are essential for the generation of coordinated increase in [Ca²⁺]_i in ‘neuronal domains’. Cereb Cortex 13: 749-757, 2003

6.Sato T, Mishina M: Representational difference analysis, high-resolution physical mapping and transcript identification of the zebrafish genomic region for a motor behavior. Genomics 82: 218-229, 2003

7.Inoue M, Mishina M, Ueda H: Locus-specific rescue of GluRε1 NMDA receptors in mutant mice identifies the brain regions important for morphine tolerance and dependence. J Neurosci 23: 6529-6536, 2003

8.Kitayama T, Mishina M, Sugiyama H: Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor ε1 subunit. Neurosci Res 47: 55-63, 2003

9.Yoshida T, Mishina M: Neuron-specific gene manipulations in transparent zebrafish embryos. Meth Cell Sci 25: 15-23, 2003

10.Mori H, Mishina M: Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting. Life Sci 74: 329-336, 2003

11.Takahashi Y, Mori H, Mishina M, Watanabe M, Fujiwara T, Shimomura J, Aiba H, Miyajima T, Saito Y, Nezu A, Nishida H, Imai K, Sakaguchi N, Kondo N: Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua. Neurology 61: 891-896, 2003

12.Kitano T, Matsumura S, Seki T, Hikida T, Sakimura K, Nagano T, Mishina M, Nakanishi S, Ito S: Characterization of N-methyl-D-aspartate receptor subunits involved in acute ammonia toxicity. Neurochem Internat 44: 83-90, 2004

13.Murai N, Tsuji J, Ito J, Mishina M, Hirano T: Vestibular compensation in glutamate receptor delta-2 subunit knockout mice: dynamic property of vestibulo-ocular reflex. Eur Arch Oto-Rhino-Laryngol 261: 82-86, 2004

14.Miyamoto Y, Yamada K, Nagai T, Mori H, Mishina M, Furukawa H, Noda Y, Nabeshima T: Behavioral adaptations to addictive drugs in mice lacking the NMDA receptor ε1 subunit. Eur J Neurosci 19: 151-158, 2004

15.Yoshida T, Katoh A, Ohtsuki G, Mishina M, Hirano T: Oscillating Purkinje neuron activity causing involuntary movement in a mutant mouse deficient in the glutamate receptor δ2 subunit. J Neurosci 24: 2440-2448, 2004

16.Matsuda N, Mishina M: Identification of chaperonin CCT γ subunit as a determinant of retinotectal development by whole-genome subtraction cloning from zebrafish no tectal neuron mutant. Development in press.

17.Uemura T, Mori H, Mishina M: Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells. Mol Cell Neurosci in press.

平野丈夫（京都大学・大学院理学研究科）

1.Minami I, Kengaku M, Sillevis Smitt P, Shigemoto R, Hirano T: Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in cerebellar Purkinje neurons. Eur J Neurosci 17: 1023-103, 2003

2.Coesmans M, Sillevis Smitt PA, Linden DJ, Shigemoto R., Hirano T, Yamakawa Y, Van Alphen AM, Luo C, Van Der Geest JN, Kros JM, Gaillard CA, Frens MA, De Zeeuw CI: Mechanism underlying cerebellar motor deficits due to mGluR1-autoantibodies. Ann Neurol 53: 325-336, 2003

3.Kitano J, Nishida M, Itsukaichi Y, Minami I, Ogawa M, Hirano T, Mori Y, Nakanishi S: Direct interaction and functional coupling between metabotropic glutamate receptor subtype 1 and voltage-sensitive Ca_V2.1 Ca²⁺ channel. J Biol Chem 278: 25101-25108, 2003

4.Murai N, Tsuji J, Ito J, Mishina M, Hirano T: Vestibular compensation in glutamate receptor δ2 subunit knockout mice: dynamic property of vestibule-ocular reflex. Eur Arch Oto-Rhino-Laryngol 65: 82-86, 2004

5.Kawaji K, Umeshima H, Eiraku M, Hirano T, Kengaku M: Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes. Mol Cell Neurosci in Press

6.Yoshida T, Katoh A, Ohtsuki G., Mishina M, Hirano T: Oscillating Purkinje Neuron Activity Causing Involuntary Eye Movement in a Mutant Mouse Deficient in the Glutamate Receptor δ2 Subunit. J Neurosci in press

饗場　篤（神戸大学・大学院医学系研究科）

1.Chida K, Hara T, Hirai T, Konishi C, Nakamura K, Nakao K, Aiba A, Katsuki M, Kuroki T: Disruption of protein kinase Cη results in impairment of wound healing and enhancement of tumor formation in mouse skin carcinogenesis. Cancer Res 63: 2404-2408, 2003

2.Kuwajima M, Hall RA, Aiba A, Smith Y: Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the monkey subthalamic nucleus. J Comp Neurol in press

石原　健（国立遺伝学研究所・構造遺伝学研究センタ−）

1.Ohkura K, Suzuki N, Ishihara T, Katsura I: SDF-9, a protein tyrosine phosphatse-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C.elegans . Development 130: 3237-3248, 2003

2.Miyahara K, Suzuki N, Ishihara T, Tsuchiya E, Katsura I: TBX2/TBX3 transcriptional factor homolog controls olfactory adaptation in Caenorhabditis elegans . J Neurobiol 58: 392-402, 2004

椛　秀人（高知医科大学・大学院医学研究科）

1.Zhang JJ, Okutani F, Inoue S, Kaba H: Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats. Neuroscience 117: 707-713, 2003

2.Zhang JJ, Okutani F, Inoue S, Kaba,H: Activation of the MAPK/ERK signaling pathway leading to CREB phosphorylation is required for the long-term facilitation process of aversive olfactory learning in young rats. Neurosicence 121: 9-16, 2003

3.Okutani F, Zhang JJ, Otsuka T, Yagi F, Kaba H: Modulation of olfactory learning in young rats through intrabulbar GABA_B receptors. Eur J Neurosci 18: 2031-2036, 2003

4.Matsuoka M, Kaba H, Moriya K, Yoshida-Matsuoka J, Costanzo RM, Norita M, Ichikawa M: Remodeling of reciprocal synapses associated with persistence of long-term memory. Eur J Neurosci in press

神谷温之（北海道大学・大学院医学研究科）

1.Tabata Y, Ouchi Y, Kamiya H, Manabe T, Arai K, Watanabe S: Retinal fate specification of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Mol Cell Biol in press

小林和人（福島県立医科大学・医学部）

1.Sano H, Yasoshima Y, Matsushita N, Kaneko T, Kohno K, Pastan I, Kobayashi K: Conditional ablation of striatal neuronal types containing dopamine D2 receptor disturbs coordination of basal ganglia function. J Neurosci 23: 9078-9088, 2003

2.Shin R-M, Masuda M, Miura M, Sano H, Shirasawa T, Song W-J, Kobayashi K. Aosaki T: Dopamine D4 receptor-induced postsynaptic inhibition of GABAergic currents in mouse globus pallidus neurons. J Neurosci 23: 11662-11672, 2003

3.Baker H, Kobayashi K. Okano H. Saino-Saito S:.Cortical and striatal expression of tyrosine hydroxylase mRNA in neonatal and adult mice. Cell Mol Neurobiol 23: 507-518, 2003

4.Okada H, Matsushita N, Kobayashi K, Kobayashi K: Identification of GABA_A receptor subunit variants in midbrain dopaminergic neurons. J Neurochem in press

5.Kobayashi K, Takahashi M, Matsushita N, Miyazaki J-I, Yaginuma H, Osumi N, Kaibuchi K, Kobayashi, K: Survival of developing motor neurons by Rho GTPase signaling pathway through Rho-kinase. J Neurosci in press

齊藤　実（東京都神経科学総合研究所）

1.Tamura T, Chiang AS, Ito N, Liu HP, Horiuchi J, Tully T, Saitoe M: Aging specifically impairs amnesiac-dependent memory in Drosophila. Neuron 40: 1003-1011, 2003

斉藤康彦（群馬大学・大学院医学系研究科）

1.Saito Y, Isa T: Local excitatory network and NMDA receptor activation generate a synchronous and bursting command from the superior colliculus. J Neurosci 23: 5854-5864, 2003

坂井貴臣（群馬大学・大学院医学系研究科）

1.Hou J, Kuromi H, Fukasawa Y, Ueno K, Sakai T. Kidokoro Y: Repetitive exposures to nicotine induce a hyper-responsiveness via the cAMP/PKA/CREB signal pathway in Drosophila. J Neurobiol in press

曽良一郎（東北大学・大学院医学系研究科）

1.Hall FS, Sora I, Uhl GR: Sex-dependent modulation of ethanol consumption in vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DAT) knockout mice. Neuropsychopharmacology 28: 620-628, 2003

2.Hall FS, Li XF, Goeb M, Roff R, Hoggatt H, Sora I, Uhl GR: Congenic C57BL/6 mu opiate receptor (MOR) knockout mice: baseline and opiate effects. Genes Brain Behav 2: 114-121, 2003

3.Yuyama K, Yamamoto H, Nakamura K, Nrshizaki I, Yamakuni T, Si-Young Song, Sora I, Nagatsu T, Yamamoto T: Overexpression of V-1 prevents NO-induced Cell Death: involvement of enhanced tetrahydrobiopterin (BH₄) biosynthesis. J Neurosci Res 72: 716-725, 2003

4.Yuyama K, Yamamoto H, Nishizaki I, Kato T, Sora I, Yamamoto T: Caspase-independent cell death by low concentrations of nitric oxide (NO) in PC12 cells: involvement of the inhibition of cytochrome c oxidase and the production of reactive oxygen species (ROS) in mitochondria. J Neurosci Res 73: 351-363, 2003

5.Itokawa M, Arai M, Kato S, Ogata Y, Furukawa A, Haga S, Ujike H, Sora I, Ikeda K, Yoshikawa T: Association between a novel polumorphism in the promoter region of the neuropeptide Y gene and schizophrenia in humans. Neurosci Lett 347: 202-204, 2003

6.Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N: Nine-or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J 3: 242-247, 2003

7.Mizoguchi H, Wu H-E, Narita M, Sora I, Hall FS, Uhl GR, Loh HH, Nigase H, Tseng F: Lack of the mu-opioid receptor-mediated G-protein activation in the mouse spinal cord lacking exon1 and exon 2 & 3 of MOR-1 gene. J Pharmacol Sci 93: 423-429, 2003

8.Shen H, Numachi Y, Yoshida S, Fujiyama K, Toda S, Awata S, Matsuoka H, Sato M: Electroconvulsive shock increases serotonin transporter in the rat frontal cortex. Neurosci Lett 341: 170-172, 2003

9.Kabbaj M, Yoshida S, Numachi Y, Matsuoka H, Sato M, Devine DP, Ueda T: Methamphetamine differentially regulates hippocampal glucocorticoid and mineralocorticoid receptors mRNAs in Fisher and Lewis rats. Mol Brain Res 117: 8-14, 2003

10.Hall FS, Goeb M, Li XF, Sora I, Uhl GR: Mu opioid receptor knockout mice display reduced cocaine conditioned place preference but enhanced sensitization of cocaine induced locomotion. Brain Res 121: 123-130, 2004

11.Shen H, Hagino Y, Kobayashi H, Shinohara-Tanaka K, Ikeda K, Yamamoto H, Yamamoto T, Lesch KP, Murphy DL, Hall FS, Uhl GR, Sora I: Regional differences in extracellular dopamine and serotonin assessed by in vivo microdialysis in mice lacking dopamine and/or serotonin transporters. Neuropsychopharmacology in press

12.Yamamoto T, Nishizaki I, Nukada T, Kamegaya F, Furuya S, Hirabayashi Y, Ikeda K, Hata H, Kobayashi H, Sora I, Yamamoto H: Functional identification of ASCT1 neutral amino acid transporter as thepredominant system for the uptake of L-serine in rat neurons in primaryculture. Neurosci Res in press

13.Ide S, Minami M, Satoh M, Uhl GR, Sora I, Ikeda K: Buprenorphine antinociception is abolished, but naloxone-sensitive reward is retained, in mu-opioid receptor knockout mice. Neuropsychopharmacology in press

14.Mansikka H, Zhao C, Sheth RN, Sora I, Uhl GR, Raja SN: Nerve injury induces a tonic bilateral: mu-opioid receptor mediated inhibitory effect on mechanical allodynia in mice. Anesthesiology in press

15.Yamamoto H, Imai K, Takamatsu Y, Kamegaya E, Hara Y, Shimada K, Yamamoto T, Shen HW, Hagino Y, Kobayashi H, Ide S, Sora I, Koga H, Ikeda K: Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment. Ann NY Acad Sci in press

16.Ide S, Kobayashi H, Tanaka K, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Ikeda K, Sora I: Gene polymorphisms of the mu opioid receptor in methamphetamine abusers. Ann NY Acad Sci in press

17.Hironaka N, Ikeda K, Sora I, Uhl GR, Niki H: Food-reinforced operant behavior in dopamine transporter knockout mice: enhanced resistance to extinction. Ann NY Acad Sci in press

18.Kobayashi H, Ide S, Hasegawa J, Ujike H, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Iyo M, Shen HW, Ikeda K, Sora I: Association study between alfa-synuclein gene polymorphism and methamphetamine dependence. Ann NY Acad Sci in press

19.Harano M, Uchimura N, Abe H, Ishibashi M, Iida N, Yanagimoto K, Tanaka T, Maeda H, Sora I, Iyo M, Komiyama T, Yamada M, Sekine Y, Inada T, Ozaki N, Ujike H: TaqI A polymorphism of DRD2 gene and brain atrophy in methamphetamine psychosis. Ann NY Acad Sci in press

20.Inada T, Iijima Y, Uchida N, Maeda T, Iwashita S, Ozaki N, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H: No association between the type 1 sigma receptor gene polymorphisms and methamphetamine abuse in the Japanese population: A collaborative study by the Japanese Genetics Initiative for Drug Abuse (JGIDA). Ann NY Acad Sci in press

21.Iwata N, Inada T, Harano M, Komiyama T, Yamada M, Sekine Y, Iyo M, Sora I, Ujike H, Ozaki N: No association between the candidate genes of t-PA/Plasminogen system and Japanese methamphetamine related disorder: A collaborative study by the Japanese Genetics Initiative for Drug Abuse (JGIDA). Ann NY Acad Sci in press

22.Numachi Y, Yoshida S, Yamashita M, Fujiyama K, Naka M, Matsuoka H, Sato M, Sora I: Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain. Ann NY Acad Sci in press

手塚　徹（東京大学・医科学研究所）

1.Nakazawa T, Watabe AM, Tezuka T, Yoshida Y, Yokoyama K, Umemori H, Inoue A, Okabe S, Manabe T, Yamamoto T: p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling. Mol Biol Cell 14: 2921-2934, 2003

2.Taniguchi S, Liu H, Nakazawa T, Yokoyama K, Tezuka T, Yamamoto T: p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn. Biochem Biophys Res Commun 306: 151-155, 2003

3.Watanabe Y, Song T, Sugimoto K, Horii M, Araki N, Tokumitsu H, Tezuka T, Yamamoto T, Tokuda M: Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthase. Biochem J 372: 465-471, 2003

4.Kim M, Tezuka T, Tanaka K, Yamamoto T: Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation. Oncogene in press

5.Goto J, Tezuka T, Nakazawa T, Tsukamoto N, Nakamura T, Ajima R, Yokoyama K, Ohta T, Ohki M, Yamamoto T: Altered gene expression in the adult brain of fyn-deficient mice. Cell Mol Neurobiol in press

根本康夫（東北大学・大学院医学系研究科）

1.Sakakibara T, Nemoto Y, Nukiwa T, Takeshima H: Identification and characterization of a novel Rho GTPase activating protein implicated in receptor-mediated endocytosis. FEBS Lett in press

松崎政紀（岡崎国立共同研究機構・生理学研究所）

1. Kasai H, Matsuzaki M, Noguchi J, Yasumatsu N Nakahara H. Structure-stability-function relationships of dendritic spines. Trends Neurosci 26: 360-368, 2003

山田勝也（秋田大学・医学部）

1.Yuan H, Yamada K, Inagaki N: Multiminute oscillations in mouse substantia nigra pars reticulata neurons in vitro. Neurosci Lett 355: 136-140, 2004

2.Yuan H, Yamada K, Inagaki N: Glucose sensitivity in mouse substantia nigra pars reticulata neurons in vitro. Neurosci Lett 355: 173-176, 2004

渡部文子（東京大学・医科学研究所）

1.Nakazawa T, Watabe AM, Tezuka T, Umemori H, Manabe T, Yamamoto T: P250GAP, A Novel Rho GTPase-Activating protein, interacts with NMDA receptor. Mol Biol Cell 14: 2921-2934, 2003

2.Opazo P, Watabe AM, Grant SGN, O’Dell TJ: Phosphatidylinositol 3-kinase regulates the induction of long-term potentiation through extracellular signal related kinase-independent mechanisms. J Neurosci 23: 3679-3688, 2003

3.Watabe AM, O’Dell TJ: Age-related changes in theta frequency stimulation-induced long-term potentiation. Neurobiol Aging 24: 267-272, 2003

和中明生（奈良県立医科大学・医学部）

1.Hagino S, Iseki K, Mori T, Zhang Y, Sakai N, Yokoya S, Hikake T, Kikuchi S, Wanaka A: Expression pattern of glypican-1 mRNA after brain injury in mice. Neurosci Lett 349: 29-32, 2003

2.Hagino S, Iseki K, Mori T, Zhang Y, Hikake T, Yokoya S, Takeuchi M, Hasimoto H, Kikuchi S, Wanaka A: Slit and glypican-1 mRNAs are coexpressed in the reactive astrocytes of the injured adult brain. Glia 42: 130-138, 2003

3.Hikake T, Mori T, Iseki K, Hagino S, Zhang Y, Takagi H, Yokoya S, Wanaka A: Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Anat Embryol 206: 373-380, 2003

4.Shibaguchi T, Kato J, Abe M, Tamamura Y, Tabata MJ, Liu JG, Iwamoto M, Wakisaka S, Wanaka A, Kurisu K: Expression and role of Lhx8 in murine tooth development. Arch Histol Cytol 66: 95-108, 2003

5.Zhang Y, Mori T, Iseki K, Hagino S, Takaki H, Takeuchi M, Hikake T, Tase C, Murakawa M, Yokoya S, Wanaka A: Differential expression of decorin and biglycan genes during palatogenesis in normal and retinoic acid-treated mice. Dev Dyn 226: 618-626, 2003

6.Mori T, Zhang Y, Takaki Y, Takeuchi Y, Iseki K, Hagino S, Kitanaka J, Takemura M, Misawa H, Ikawa M, Okabe M, Wanaka A: The LIM homeobox gene, L3/Lhx8, is necessary for proper development of basal forebrain cholinergic neurons. Eur J Neurosci in press