2.Maruyama M, Arai H, Okamura N, Matsui M, Sasaki H: Biomarkers in subjects with amnestic mild cognitive impairment. J Am Geriat Soc 51: 1671-1672, 2003

3.Kanda A, Matsui T, Ebihara S, Arai H, Sasaki H: Periventricular white matter lesions and sleep alternation in older people. J Am Geriat Soc 51: 432-433, 2003

4.Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinson’s disease. Ann Neurol 54: 276-277, 2003

5.Seki T, Kurusu M, Haruko Tanji, Arai H, Sasaki H: Acupuncture and swallowing reflex in poststroke patients. J Am Geriat Soc 51: 726-727, 2003

6.Buerger K, Zinkowski R, Teipel SJ, Arai H, DeBernardis J, Kerkman D: Differentiation between geriatric major depression and Alzheimer’s disease with CSF tau protein phosphorylated at threonine 231. Am J Psychiat 160: 376-379, 2003

7.Clark CM, Ewbank D, Peskind E, Galasko D, Morris JC, Farlow M, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, DeCarli C, Leight S, Lee V.M-Y, Trojanowski JQ. Cerebrospinal fluid tau and ß-amyloid : How well do these biomarkers reflect autopsy confirmed dementia diagnoses? Arch Neurol 60:1696-1702, 2003

8.Itoh N, Ishiguro K, Arai H, Kokubo Y, Sasaki R, Narita Y, Kuzuhara S: Biochemical and ultrastructual study of neurofibrillary tangles in amyotrophic lateral sclerosis/parkinsonism-dementia complex in the Kii peninsula of Japan. J Neuropathol Exp Neurol 62: 791-798, 2003

9.Matsui T, Arai H, Nakajo M, Maruyama M, Ebihara S, Sasaki H, Yoshida Y. Role of chronic sinusitis in cognitive functioning in the elderly. J Am Geriat Soc 51: 1818-1819, 2003

10.Kosaka Y, Satoh-Nakagawa T, Ohrui T, Yamaya M, Arai H, Sasaki H: Tube feeding in terminal care. Geriat Gerontol Int 3: 172-174, 2003

11.Iwasaki K, Kobayashi S, Chimura Y, Taguchi M, Inoue K, Akiba T, Arai H. Cyong J-C, Sasaki H: A randomized, double-blind, placebo-controlled clinical trial of the Chinese herbal medicine Ba Wei Di Huang Wan” in the treatment of dementia. J Am Geriat Soc in press

12.Ohrui T, Matsui T, Yamaya M, Arai H, Sasaki H: ACE inhibitors and incidence of Alzheimer’s disease. J Am Geriat Soc in press

13.Okamura N, Maruyama M, Ebihara T, Arai H, Sasaki H: Aspiration pneumonia and insular hypoperfusion in patients with cerebrovascular disease. J Am Geriat Soc in press

14.Okamura N, Suemoto T, Shimadzu H, Suzuki M, Shiomitsu T, Akatsu H, Yamamoto T, Staufenbiel M, Yanai K, Arai H, Sasaki H, Kudo Y, Sawada T: Styrylbenzoxazole derivatives for in vivo imaging of amyloid plaques in the brain. J Neurosci in press

15.Okamura N, Suemoto T, Shiomitsu T, Suzuki M, Shimadzu H, Akatsu H, Yamamoto T, Arai H, Sasaki H, Yanai K, Staufenbiel M, Kudo Y, Sawada T: A novel imaging probe for in vivo detection of neuritic and duffuse plaques in the brain. J Mol Neurosci in press

16.Maruyama M, Matsui T, Tanji H, Memoto N, Tomita N, Ootsuki M, Arai H, Sasaki H: Cerebrospinal fluid tau protein and periventricular white matter lesions in aging, stable and progressive mild cognitive impairment: Implications for two major pathways. Arch Neurol in press

浦上克哉（鳥取大学・医学部）

1.Watanabe Y, Shimizu Y, Urakami K, Matsushima E, Nakashima K: Vertical ophthalmoplegia in a demented patient with striatopallidodentate calcification. Psychiat Clin Neurosci 57: 447-450, 2003

2.Inoue M, Suyama A, Kato T, Urakami K, Nakashima K, Meshitsuka S: Development of computerized Kana Pick out test for the neuropsychological examination. Comput Meth Programs Biomed 70: 271-276, 2003

3.Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y, Mori M, Kawashima M, Kowa H, Adachi Y, Urakami K, Nakashima K: Population based door-to-door survey of migraine in Japan: the Daisen Study. Headache 44: 8-19, 2004

4.Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: The regulatory region polymorphisms of the MTHFR gene are not associated with Alzheimer's disease. Dement Geriat Cogn Disord 17: 147-150, 2004

5.Wakutani Y, Kowa H, Kusumi M, Nakaso K, Yasui K, Wada-Isoe K, Urakami K, Takeshima T, Nakashima K: A haplotype of the methylenetetrahydrofolate reductase gene is protective against late-onset Alzheimer's disease. Neurobiol Aging 25: 291-294, 2004

6.Wakutani Y, Watanabe K, Adachi Y, Isoe-Wada K, Urakami K, Ninomiya H, Hashimoto H, Saido TC, Iwatsubo T, Nakashima K: Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease. J Neurol Neurosurg Psychiat in press

7.Wada-Isoe K, Wakutani Y, Urakami K, Nakashima K: Elevated interleukin-6 levels in cerebrospinal fluid of vascular dementia patients. Acta Neurol Scand in press

樋口 進（国立療養所久里浜病院・臨床研究部）

1.Yamaya N, Nakayama K, Ebihara S, Hirai H, Higuchi S, Sasaki H: Relationship between microsatellite polymorphism in the haem oxynase-1 gene promoter and longevity of the normal Japanese population. J Med Genet 40: 146-148, 2003

2.Suzuki Y, Taniyama M, Muramatsu T, Higuchi S, Ohta S, Atsumi Y, Matsuoka K: Diabetic vasculopathy and alcohol torelance trait in type 2 diabetes. Diabet Care 26: 246-247, 2003

3.Suzuki Y, Matsuura N, Suzuki S, Muramatsu T, Taniyama T, Ohta S, Higuchi S, Atusmi Y, Matsuoka K: Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Diabet Res Clin Pract 60: 139-141, 2003

4.Mochizuki H, Masaki T, Kamakura K, Matsushita S, Kusunoki S, Higuchi S: Acute axonal polyneuropathy associated with alcoholism. Eur Neurol 50: 183-184, 2003

5.Mochizuki H, Masaki T, Miyakawa T, Nakane J, Yokoyama A, Nakamura Y, Okuyama K, Kamakura K, Motoyoshi K, Matsushita S, Higuchi S: Benign type of central pontine myelinolysis in alcoholism: clinical neuropathological and electrophysiological findings. J Neurol 250: 1077-1083, 2003

6.Masaki T, Matsushita S, Arai H, Takeda A, Itoyama Y, Mochizuki H, Kamakura K, Ohara S, Higuchi S: Association between polymorphism of BDNF gene and sporadic Parkinson’s disease. Ann Neurol 54: 276-277, 2003

7.Yokoyama A, Yokoyama T, Muramatsu T, Omori T, Matsushita S, Higuchi S, Maruyama K, Ishii H: Macrocytosis, a new predictor of esophageal squamous cell carcinoma in Japanese alcoholic men. Carcinogenesis 24: 1773-1778, 2003

8.Miyatake R, Furukawa A, Matsushita S, Higuchi S, Suwaki H: Functional polymorphisms in the sigma-1 receptor gene associated with alcoholism. Biol Psychiat 55: 85-90, 2004

9.Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Maruyama K, Niino N, Ando F, Shimokata H, Ohta S, Funakoshi A: Association of chelocystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese population. Alcohol 39: 25-28, 2004

10.Miyasaka K, Yoshida Y, Matsushita S, Higuchi S, Shirakawa O, Shimokata H, Funakoshi A: Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in Japanese. Am J Med Genet in press

11.Matsushita S, Suzuki K, Murayama M, Nishiguchi N, Hishimoto A, Takeda A, Shirakawa O, Higuchi S: Serotonin transporter regulatory region polymorphism is associated with “core” anorexia nervosa. Am J Med Genet in press

12.Adachi J, Matsushita S, Yoshioka N, Funae R, Fujita T, Higuchi S, Ueno Y: Plasma phosphatidylcholine hydroperoxidase as a new marker of oxidative stress in alcoholic patients. J Lipid Res in press

13.Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S, Koike K, Okamura N, Matsushita M, Suzuki K, Murayama M, Higuchi S, and Iyo M: Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disorders. Am J Med Genet in press

朝田　隆（筑波大学・臨床医学系）

1.Sakasegawa Y, Kishida H, Sakurai M, Asada T, Kinoshita T, Goto Y, Kimura H, Kuroiwa Y, Hachiya NS, Kaneko K: Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer’s disease in a Japanese population. Neurosci Lett 353:49-52, 2003

2.Hori M, Asada T: Life-style regularity and core body temperature phase in delayed sleep phase syndrome. Sleep Biol Rhythms 1: 251-252, 2003

3.Tanaka N, Kinoshita T, Asada T, Ohashi Y: Long-linear models for assessing gene-age interaction and their application to case-control studies of the apolipoprotein E (apoE) gene in Alzheimer’s disease. J Hum Genet 48: 520-524, 2003

4.Ota M, Mizukami K, Katano T, Sato S, Takeda T, Asada T: A case of delusional disorder, somatic type with remarkable improvement of clinical symptoms and single photon emission computed tomography findings following modified electroconvulsive therapy. Prog Neuropsychopharmacol Biol Psychiat 27: 881-884, 2003

5.Ohkubo T, Sakasegawa Y, Asada T, Kinoshita T, Goto Y, Kimura H, Mizusawa H, Hachiya NS, Kaneko K. Absence of association between codon 129/219 polymorphisms of the prion protein gene and Alzheimer’s disease in Japan. Ann Neurol 54: 553-554, 2003

6.Matsuda H, Ohnishi T, Asada T, Zhi-jie Li, Kanetaka H, Imabayashi E, Tanaka F, Nakano S: Correction for partial-volume effects on brain perfusion SPECT in healthy men. J Nucl Med 44: 1243-1252, 2003

7.Sakamoto S, Matsuda H, Asada T, Ohnishi T, Nakano S, Kanetaka H, Takasaki M: Apolipoprotein E genotype and early Alzheimer's disease: a longitudinal SPECT study. J Neuroimaging 13: 113-123, 2003

8.Nemoto K, Mizukami K, Mizuhiki T, Asada T: Eating disorder with hyperthyroidism. Psychiat Clin Neurosci 57: 341-342, 2003

9.Ide M, Mizukami K, Fujita T, Ashizawa Y, Asada T: A case of neurosyphilis showing a marked improvement of clinical symptoms and cerebral blood flow on single photon emission computed tomography with quantitative penicillin treatment. Prog Neuropsychopharmacol Biol Psychiat 28: 417-20, 2004

10.Tanahashi H, Asada T, Tabira T: Association between tau polymorphism and male early-onset Alzheimer’s disease. NeuroReport 15: 175-180, 2004

11.Ishikawa M, Mizukami K, Iwakiri M, Hidaka S, Kamma h, AsadaT: Alterations of heterogeneous nuclear RNP A2 and B1 in the hippocampus of the rat after perforant pathway lesion. Acta Neuropathol 107: 144-148, 2004

東海林幹夫（岡山大学・大学院医歯学総合研究科・神経病態内科学）

1.Imai Y, Soda M, Murakami T, Shoji M, Abe K, Takahashi R: A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. J Biol Chem 278: 51901-51910, 2003

2.Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Ikbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. J Neurochem 85: 1101-1108, 2003

3.Iwai M, Sato K, Kamada H, Omori N, Nagano I, Shoji M, Abe K: Temporal profile of stem cell division, migration, and differentiation from subventricular zone to olfactory bulb after transient forebrain ischemia in gerbils. J Cereb Blood Flow Metab 23: 331-341, 2003

4.Kamada H, Sato K, Zhang WR, Omori N, Nagano I, Shoji M, Abe K: Spatiotemporal changes of apolipoprotein E immunoreactivity and apolipoprotein E mRNA expression after transient middle cerebral artery occlusion in rat brain. J Neurosci Res 73: 545-556, 2003

5.Ilieva H, Nagano I, Murakami T, Shiote M, Shoji M, Abe K: Sustained induction of survival p-AKT and p-ERK signals after transient hypoxia in mice spinal cord with G93A mutant human SOD1 protein. J Neurol Sci 215: 57-62, 2003

6.Murakami T, Ilieva H, Shiote M, Nagata T, Nagano I, Shoji M, Abe K: Hypoxic induction of vascular endothelial growth factor is selectively impaired in mice carrying the mutant SOD1 gene. Brain Res 989: 231-237, 2003

7.Li F, Omori N, Jin G, Wang SJ, Sato K, Nagano I, Shoji M, Abe K: Cooperative expression of survival p-ERK and p-Akt signals in rat brain neurons after transient MCAO. Brain Res 962: 21-26, 2003

8.Ohta K, Iwai M, Sato K, Omori N, Nagano I, Shoji M, Abe K: Dissociative increase of oligodendrocyte progenitor cells between young and aged rats after transient cerebral ischemia. Neurosci Lett 335: 159-162, 2003

9.Wang SJ, Omori N, Li F, Jin G, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Functional improvement by electro-acupuncture after transient middle cerebral artery occlusion in rats, Neurol Res 25: 516-521, 2003

10.Manabe Y, Wang JM, Shiote M, Murakami T, Nagano I, Shoji M, Abe K: Glutamate enhances caspase-3 immunoreactivity in cultured spinal cord neurons of newborn rats. Neurol Res 25: 312-316, 2003

11.Omori N, Maruyama K, Jin G, Li F, Wang SJ, Hamakawa Y, Sato K, Nagano I, Shoji M, Abe K: Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferring. Neurol Res 25: 275-279, 2003

12.Jin G, Omori N, Li F, Nagano I, Manabe Y, Shoji M, Abe K: Protection against ischemic brain damage by GDNF affecting cell survival and death signals. Neurol Res 25: 249-253, 2003

13.Manabe Y, Nagano I, Gazi MS, Murakami T, Shiote M, Shoji M, Kitagawa H, Abe K: Glial cell line-derived neurotrophic factor protein prevents motor neuron loss of transgenic model mice for amyotrophic lateral sclerosis. Neurol Res 25: 195-200, 2003

14.Sato K, Iwai M, Nagano I, Shoji M, Abe K: Temporal and spatial changes of highly polysialylated neural cell adhesion molecule immunoreactivity in amygdala kindling development. Neurol Res 25: 79-82, 2003

15.Kamada H, Sato K, Iwai M, Zhang WR, Nagano I, Manabe Y, Shoji M, Abe K: Temporal and spatial changes of free cholesterol and neutral lipids in rat brain after transient middle cerebral artery occlusion, Neurosci Res 45: 91-100, 2003

16.Murakami T, Shoji M, Imai Y, Inoue H, Kawarabayashi T, Matsubara E, Harigaya Y, Sasaki A, Takahashi R, Abe K: Pael-R is accumulated in Lewy bodies of Parkinson’s disease. Ann Neurol 55: 439-442, 2004

17.Moreira MC, Klur S, Watanabe M, Nemeth AH, Ber IL, Moniz JC, Tranchant C, Aubourg P, Tazir M, Schols L, Pandolfo M, Schulz JB, Pouget J, Calvas P, Shizuka-Ikeda M, Shoji M, Tanaka M, Izatt L, Shaw CE, M'Zahem A, Dunne E, Bomont P, Benhassine T, Bouslam N, Stevanin G, Brice A, Guimaraes J, Mendonca P, Barbot C, Coutinho P, Sequeiros J, Durr A, Warter JM, Koenig M: Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2. Nat Genet in press

18.Kawarabayashi T, Shoji M, Younkin L, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG: Dimeric Aß rapidly accumulates in lipid rafts followed by ApoE and phosphorylated tau as memory is impaired in the Tg2576 mouse model of Alzheimer’s disease. J Neurosci in press

19.Matsubara E, Sekijima Y, Tokuda T, Urakami K, Amari M, Shizuka-Ikeda M, Tomidokoro Y, Ikeda M, Kawarabayashi T, Harigaya Y, Ikeda S, Murakami T, Abe K, Otomo E, Hirai S, Frangione B, Ghiso J, Shoji M: Soluble Aß homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteins. Neurobiol Aging in press

20.Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Shoji M: Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging in press