筑波大学医学医療系・分子遺伝疫学研究室は「ヒトゲノム多様性と疾患」をキーワードとして研究に取り組んでいます。

研究業績

分子遺伝疫学研究室 2007年以降の研究業績

2006年までの業績は個人のページをご覧ください

2013

英文原著 (corresponding authorを*で示す)

Naka I, Ohashi J*, Kimura R, Inaoka T, Matsumura Y. Association of ADRB2 polymorphism with triglyceride levels in Tongans. Lipids in Health and Disease 12: 110.

Kawasaki A, Inoue N, Ajimi C, Sada K, Kobayashi, Yamada H, Furukawa H, Sumida T, Tohma S, Miyasaka N, Matsuo S, Ozaki S, Hashimoto H, Makino H, Harigai M, Tsuchiya N*. Association of IRF5 polymorphism with MPO-ANCA positive vasculitis in a Japanese population. Genes Immun 2013; 14, 527-529. doi: 10.1038/gene.2013.45.

Furukawa H*,Oka S, Takehana K, Muramatsu T, Shimada K, Komiya A, Fukui N, Tsuchiya N, Tohma S.Plasma amino acid profiles in collagen disease patients with interstitial lung disease. Immunome Res 2013; 9: 064. doi: 10.4172/1745-7580.1000064

Mita T*, Ohashi J, Nakamura M, Endo H, Tanabe K. Ordered accumulation of mutations conferring resistance to sulfadoxine-pyrimethamine in the Plasmodium falciparum parasite. J Infect Dis in press.

Oka S, Furukawa H*, Kashiwase K, Tsuchiya N, Tohma S. Novel HLA-DQB1*04 (DQB1*04:10) allele in the Japanese population. Tissue Antigens 2013; 82:148-149. doi: 10.1111/tan.12135

Genin E, Coustet B, Allanore Y, Ito I, Teruel M, Constantin A, Schaeverbeke T, Adeline Ruyssens-Witran, Tohma S, Cantagrel A, Vittecoq O, Barnetche T, Le Loët X, Fardellone P, Furukawa H, Meyer O, Chiocchia G, Tsuchiya N, Martin J, Dieudé P.* Epistatic interaction between BANK1 and BLK in rheumatoid arthritis: results from a large trans-ethnic meta-analysis. PLoS One 2013; 8(4), e61044. doi:10.1371/journal.pone.0061044.

Furusawa T*, Naka I, Yamauchi T, Natsuhara K, Eddie R, Kimura R, Nakazawa M, Ishida T, Inaoka T, Matsumura Y, Ataka Y, Ohtsuka R, Ohashi J. Hypertension susceptibility gene prevalence in the Pacific islands and associations with hypertension in Melanesia. J Hum Genet 2013; 58: 142-149.

Umeda N, Matsumoto I*, Ito I, Kawasaki A, Tanaka Y, Inoue A, Tanaka Y, Tsuboi H, Suzuki T, Hayashi T, Ito S, Tsuchiya N, Sumida T. Identification of anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis. Clin Exp Immunol 2013;172(1):44-53. doi: 10.1111/cei.12033.

Oka S, Furukawa H*, Shimada K, Hayakawa H, Fukui N, Tsuchiya N, Tohma S. Serum biomarker analysis of collagen disease patients with acute-onset diffuse interstitial lung disease. BMC Immunol 2013:14,9. doi:10.1186/1471-2172-14-9

Furukawa H*, Kawasaki A, Oka S, Shimada K, Nakayama H, Matsui T, Ikenaka T, Hashimoto A, Okazaki Y, Takaoka H, Futami H, Komiya A, Kondo Y, Ito S, Hayashi T, Matsumoto I, Kusaoi M, Takasaki Y, Nagai T, Hirohata S, Setoguchi K, Nagaoka S, Kono H, Okamoto A, Fukui N, Hashimoto H, Sumida T, Ono M†, Tsuchiya N†, Tohma S.† (†equal senior author) Association of a single nucleotide polymorphism in the SH2D1A intronic region with systemic lupus erythematosus. Lupus 2013;22:497-503. doi: 10.1177/0961203313479421.

Naka I, Hikami K, Nakayama K, Koga M, Nishida N, Kimura R, Furusawa T, Natsuhara K, Yamauchi T, Nakazawa M, Ataka Y, Ishida T, Inaoka T, Iwamoto S, Matsumura Y, Ohtsuka R, Tsuchiya N, Ohashi J*. A functional SNP upstream of the beta-2 adrenergic receptor gene (ADRB2) is associated with obesity in Oceanic populations. Int J Obes doi: 10.1038/ijo.2012.206.

Terao C*, Ohmura K*, Kawaguchi Y, Nishimoto T, Kawasaki A, Takehara K, Furukawa H, Kochi Y, Ota Y, Ikari K, Sato S, Tohma S, Yamada R, Yamamoto K, Kubo M, Yamanaka H, Kuwana M, Tsuchiya N, Matsuda F, Mimori T. PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population. Arthritis Rheum 2013;65(2):472-480.

Furukawa H*, Oka S, Matsui T, Hashimoto A, Arinuma Y, Komiya A, Fukui N, Tsuchiya N, Tohma S. Genome, epigenome and transcriptome analyses of a pair of monozygotic twins discordant for systemic lupus eythematosus. Hum Immunol 2013;74(2):170–175.

Furukawa H*, Oka S, Shimada K, Sugii S, Hashimoto A, Komiya A, Fukui N, Miyashita T, Migita K, Suda A, Nagaoka S, Tsuchiya N, Tohma S. Association of increased frequencies of HLA-DPB1*05:01 with the presence of anti-Ro/SS-A and anti-La/SS-B antibodies in Japanese rheumatoid arthritis and systemic lupus erythematosuspatients. PLoS One 2013; 8(1): e53910. doi:10.1371/journal.pone.0053910.

Furukawa H*, Oka S, Shimada K, Rheumatoid Arthritis associated Interstitial Lung Disease (RA-ILD) Study Consortium, Tsuchiya N, Tohma S. HLA-A*31:01 and methotrexate-induced interstitial lung disease in Japanese rheumatoid arthritis patients: a multi-drug hypersensitivity marker? Ann Rheum Dis 2013;72(1):153-155.

英文総説

Tsuchiya N*Genetics of ANCA-associated vasculitis in Japan - a role for HLA-DRB1*09:01 haplotype. Clin Exp Nephrol 2013; 17:628-630.

特集企画

土屋尚之:「リウマチ・膠原病のゲノム解析update」炎症と免疫 2013;21(5)

和文総説

土屋尚之:SLEの疾患感受性遺伝子研究2013. リウマチ科 2013;50(5), 517-524.

土屋尚之:序(特集「リウマチ・膠原病のゲノム解析update」) 炎症と免疫 2013;21(5), 371-372.

土屋尚之:GPAとMPAの遺伝学的相違. リウマチ科 2013;49(5), 611-615.

土屋尚之:HLA~still alive and well. アレルギー・免疫 2013;20(6), 821-822.

土屋尚之:ANCA関連血管炎疾患感受性遺伝子.日本臨床 2013;71(suppl 1), 208-213.

土屋尚之:全身性エリテマトーデスの疾患感受性遺伝子. 腎と透析 2013;74(1)15-20.

achieve

セミナー情報

入試情報

Key Words

ヒトゲノム、遺伝子多型、
人類遺伝、自己免疫疾患、
膠原病、
全身性エリテマトーデス(SLE)、
関節リウマチ、
ANCA関連血管炎、
全身性強皮症、病因解明、
個別化医療

医学医療系 登録研究グループ (リサーチグループ)

ゲノム医科学 リサーチユニッ卜

難治性免疫疾患・アレルギー リサーチユニッ卜

当研究室メンバーは、筑波大学において認定された「ゲノム医科学リサーチユニッ卜
難治性免疫疾患・アレルギーリサーチユニッ卜」の構成員です。

〒305-8575 茨城県つくば市天王台1-1-1 電話029-853-2111(代表)

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筑波大学医学医療系・分子遺伝疫学研究室は「ヒトゲノム多様性と疾患」をキーワードとして研究に取り組んでいます。

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