業績集

平成14年度
       
A01班
A02班
A03班
A04班
B01班
B02班
B03班
ゲノム班
A02班

津本忠治(大阪大学・大学院医学系研究科)

1.Ohshima M, Hata Y, Ichisaka S, Wakita M, Fukuda M, Kameyama K, Tsumoto T: Chronic, electrical stimulation of afferents from one eye changes ocular dominance of visual cortical neurones in kittens. J Neurophysiol 88: 2147-2151, 2002

2.Yasuda H, Higashi H, Kudo Y, Inoue T, Hata Y, Mikoshiba K, Tsumoto, T: Imaging of calcineurin activated by long-term depression-inducing synaptic inputs in living neurons of rat visual cortex. Eur J Neurosci 17: 287-297, 2003

3.Akaneya Y, Altibaev R Sh, Bayazitov IT, Kinoshita S, Voronin LL, Tsumoto T: Low-frequency depression of synaptic responses recorded from rat visual cortex. Neuroscience 117: 305-320, 2003

4.Ichisaka S, Katoh-Semba R, Hata Y, Ohshima M, Kameyama K, Tsumoto T: Activity-dependent changes in the protein level of brain-derived neurotrophic factor but no change in other neurotrophins in the visual cortex of young and adult ferrets. Neuroscience 117: 361-371, 2003

5.Salami M, Itami C, Tsumoto T, Kimura F: Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex. Proc Natl Acad Sci USA in press

6.Jiang B, Akaneya Y, Hata Y, Tsumoto T: Long-term depression is not induced by low frequency stimulation in rat visual cortex in vivo: A possible preventing role of endogenous BDNF. J Neurosci in press

中村 俊(国立精神・神経センター・神経研究所)

1.Koshiba M, Kikuchi T, Yohda M, Nakamura S: Inversion of the anatomical lateralization of chick thalamofugal visual pathway by light experience. Neurosci Lett 318: 113-118, 2002

2.Hoshino M, Nakamura S: The Ras-like small GTP-binding protein Rin is activated by growth factor stimulation. Biochem Biophys Res Commun 295: 651-656, 2002

3.Ohsaki K, Osumi N, Nakamura S: Altered whisker patterns induced by ectopic expression of Shh are topographically represented by barrels. Dev Brain Res 137: 159-170, 2002

4.Koshiba M, Nakamura S, Deng C, Rogers LJ: Light-dependent development of asymmetry in the ispilateral and contralateral thalamofugal visual projections of the chick. Neurosci Lett 336: 81-84, 2002

5.Katagiri T, Sakakibara A, Takahashi T, Nakamura S, Hattori S: Ack1 upregulates integrin-mediated adhesion of T cells upon TCR stimulation. J Biol Chem in press

井本敬二(岡崎国立共同研究機構 ・生理学研究所)

1.Morii T, Sato S, Hagihara M, Mori Y, Imoto K, Makino K: Structure-based design of a leucine zipper protein with new DNA contacting region. Biochemistry 41: 2177-2183, 2002

2.Morii T, Sugimoto K, Makino K, Otsuka M, Imoto K, Mori Y: A new fluorescent biosensor for inositol trisphosphate. J Am Chem Soc 124: 1138-1139, 2003

3.Matsushita K, Wakamori M, Rhyu I.-J, Arii T, Oda S, Mori Y, Imoto K: Bidirectional alterations in cerebellar synaptic transmission of tottering and rolling Ca2+ channel mutant mice. J Neurosci 22: 4388-4398, 2002

4.Kato K, Wakamori M, Mori Y, Imoto K, Kitamura K: Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells. Neuropharmacology 42: 1099-1108, 2002

5.Akiba I, Seki T, Mori M, Iizuka M, Nishimura S, Sasaki S, Imoto K, Barsoumian EL: Stable expression and characterization of human PN1 and PN3 sodium channels. Receptors Channels in press

岡部繁男(東京医科歯科大学・大学院医歯学統合研究科)

1.Ebihara T, Komiya Y, Izumi-Nakaseko H, Adachi-Akahane S, Okabe S, Okamura Y: Coexpression of a Cav1.2 protein lacking N-terminus and the first domain specifically suppresses L-type calcium channel activity. FEBS Lett 529: 203-207, 2002

2.Nakatomi H, Kuriu T, Okabe S, Yamamoto S, Hatano O, Kawahara N, Tamura A, Kirino T, Nakafuku M: Regeneration of hippocampal pyramidal neurons by recruitment of endogenous neural progenitors: An animal model for a neuronal replacement therapy for ischemic brain injury. Cell 110: 429-441, 2002

3.Usui S, Konno D, Hori K, Maruoka H, Okabe S, Fujikado T, Tano Y, Sobue K: Synaptic targeting of PSD-Zip45 (Homer 1c) and its involvement in the synaptic accumulation of F-actin. J Biol Chem in press

4.Enomoto M, Shinomiya K, Okabe S: Migration and differentiation of neural progenitor cells from two different regions of embryonic central nervous system after transplantation into the intact spinal cord. Eur J Neurosci in press

5.Ebihara T, Kawabata I, Usui S, Sobue K, Okabe S: Synchronized formation and remodeling of postsynaptic densities: long-term visualization of hippocampal neurons expressing postsynaptic density proteins tagged with GFP. J Neurosci in press

岡村康司(岡崎国立共同研究機構・統合バイオサイエンスセンター)

1.Ebihara T, Komiya Y, Izumi-Nakaseko H, Adachi-Akahane S, Okabe S, Okamura Y: Coexpression of a Cav1.2 protein lacking an N-terminus and the first domain specifically suppresses L-type calcium channel activity. FEBS Lett 529: 203-207, 2002

2.Okada T, Katsuyama Y, Ono F, Okamura Y: The development of three identified motor neurons in ascidian embryo. Dev Biol 244: 278-92, 2002

3.Katsuyama Y, Matsumoto J, Okada T, Ohtsuka Y, Cheng L, Okado H, Okamura Y: Regulation of synaptotagmin gene expression during ascidian embryogenesis. Dev Biol 244: 293-304, 2002

4.Nakajo K, Katsuyama Y, Ono F, Ohtsuka Y, Okamura Y: Identification,functional characterization and developmental expression of the ascidian Kv4-class potassium channel. Neurosci Res 45: 59-70, 2003

佐藤勝重(東京医科歯科大学・大学院医歯学総合研究科)

1.Sato K, Nariai T, Sasaki S, Yazawa I, Mochida H, Miyakawa N, Momose-Sato Y, Kamino K, Ohta Y, Hirakawa K, Ohno K: Intraoperative intrinsic optical imaging of neuronal activity from subdivisions of the human primary somatosensory cortex. Cereb Cortex 12: 269-280, 2002

2.Sato K, Mochida H, Yazawa I, Sasaki S, Momose-Sato Y: Optical approaches to functional organization of glossopharyngeal and vagal motor nuclei in the embryonic chick hindbrain. J Neurophysiol 88: 383-393, 2002

3.Sato K, Mochida H, Sasaki S, Momose-Sato Y: Developmental organization of the glossopharyngeal nucleus in the embryonic chick brainstem slice as revealed by optical sectioning recording. Neurosci Lett 327: 157-160, 2002

4.Sasaki S, Yazawa I, Miyakawa N, Mochida H, Shinomiya K, Kamino K, Momose-Sato Y, Sato K: Optical imaging of intrinsic signals induced by peripheral nerve stimulation in the in vivo rat spinal cord. Neuroimage 17: 1240-1255, 2002

5.Kinoshita M, Ueda R, Kojima S, Sato K, Watanabe M, Urano A, Ito E: Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout. Eur J Neurosci 16: 868-876, 2002

6.Momose-Sato Y, Miyakawa N, Mochida H, Sasaki S, Sato K: Optical analysis of large-scale depolarization waves in the embryonic brain: a dual network of gap junctions and chemical synapses. J Neurophysiol 18: 600-614, 2003

7.Momose-Sato Y, Mochida H, Sasaki S, Sato K: Depolarization waves in the embryonic CNS triggered by multiple sensory inputs and spontaneous activity: optical imaging with a voltage-sensitive dye. Neuroscience in press

8.Miyakawa N, Yazawa I, Sasaki S, Momose-Sato Y, Sato K: Optical analysis of acute spontaneous epileptiform discharges in the in vivo rat cerebral cortex. Neuroimage in press

9.Sato K, Momose-Sato Y: Optical detection of developmental origin of synaptic function in the embryonic chick vestibulo-cochlear nuclei. J Neurophysiol in press

宋 文杰(大阪大学・大学院工学研究科)

1.Song W-J: Genes responsible for native depolarization-activated K+ currents in neurons. Neurosci Res 42: 7-14, 2002

2.Hattori S, Murakami F, Song W-J: Rundown of a transient potassium current is attributable to change in channel voltage-dependence. Synapse in press

3.Hattori S, Murakami F, Song W-J: Quantitative relationship between Kv4.2 mRNA and A-type potassium current in rat striatal cholinergic interneurons during postnatal development. J Neurophysiol in press

程 肇(東京大学・医科学研究所)

1.Abe M, Herzog ED, Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD: Circadian rhythms in isolated brain region. J Neurosci 22: 350-356, 2002

2.Yamazaki S, Straume M, Tei H, Sakaki Y, Menaker M, Block GD: Effects of aging on the circadian rhythms of central and peripheral mammalian clocks. Proc Natl Acad Sci USA 99: 10801-10806, 2002

3.Constance CM, Green CB, Tei H, Block GD: Bulla gouldiana period exhibits unique regulation at the mRNA and protein levels. J Biol Rhythms 17: 413-427, 2002

4.Kojima S, Hirose M, Tokunaga K, Sakaki Y, Tei H: Structural and functional analysis of 3' untranslated region of mouse Period1 mRNA. Biochem Biophys Res Commun 301: 1-7, 2003

富永真琴(三重大学・医学部)

1.Numazaki M, Tominaga T, Toyooka H, Tominaga M: Direct phosphorylation of capsaicin receptor VR1 by PKCe and identification of two target serine residues. J Biol Chem 277: 13375-13378, 2002

2.Sugiua T, Tominaga M, Katsuya H, Mizumura K: Bradykinin lowered the threshold temperature for heat activation of vanilloid receptor 1. J Neurophysiol 88: 544-548, 2002

橋本浩一(金沢大学・大学院医学系研究科)

1.Watase K, Weeber EJ, Xu B, Antalffy B, Yuva-Paylor L, Hashimoto K, Kano M, Atkinson R, Sun Y, Armstrong DL, Sweatt JD, Orr HT, Paylor R, Zoghbi HY: A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration. Neuron 34: 905-919, 2002

林 基治(京都大学・霊長類研究所)

1.Higo N, Oishi T, Yamashita A, Matsuda K, Hayashi M: Northern blot and in situ hybridization analyses of MARCKS mRNA expression in the cerebral cortex of the macaque monkey. Cereb Cortex 12: 552-564, 2002

2.Oishi T, Higo N, Matsuda K, Hayashi M: Expression of superior cervical ganglion-10 (SCG-10) mRNA in the monkey cerebral cortex during postnatal development. Neurosci Lett 323: 199-202, 2002

3.Mori T, Yamashita D, Homma KJ, Shimizu K, Hayashi M: Changes in NT-3 and TrkC in the primary visual cortex of developing macaques. Neuroreport 13: 1689-1694, 2002

4.Higo N, Oishi T, Yamashita A, Matsuda K, Hayashi M: Expression of MARCKS mRNA in lateral geniculate nucleus and visual cortex of normal and monocularly deprived macaque monkeys. Vis Neurosci 19: 633-643, 2002

福田敦夫(浜松医科大学・医学部)

1.Farkas I, Baranyi L, Ishikawa Y, Okada N, Bohata C, Budai D, Fukuda A, Imai M, Okada H: CD59 blocks not only the insertion of C9 into MAC but inhibits ion channel formation of homologous C5b-8 as well as C5b-9. J Physiol 539: 537-545, 2002

2.Ueno T, Okabe A, Akaike N, Fukuda A, Nabekura J: Diversity of neuron-specific K+-Cl- cotransporter expression and inhibitory postsynaptic potential depression in rat motoneurons. J Biol Chem 277: 4945-4950, 2002

3.Nabekura J, Ueno T, Okabe A, Furuta A, Iwaki T, Shimizu-Okabe C, Fukuda A, Akaike N: Reduction of KCC2 expression and GABAA receptor-mediated excitation following in vivo axonal injury. J Neurosci 22: 4412-4417, 2002

4.Kilb W, Ikeda M, Uchida K, Okabe A, Fukuda A, Luhmann HJ: Depolarizing glycine responses in Cajal-Retzius cells of neonatal rat cerebral cortex. Neuroscience 112: 299-307, 2002

5.Mikawa S, Wang C, Shu F, Wang T, Fukuda A, Sato K: Developmental changes in KCC1, KCC2, and NKCC1 mRNAs in the rat cerebellum. Dev Brain Res 136: 93-100, 2002

6.Okabe A, Ohno K, Toyoda H, Yokokura M, Sato K, Fukuda A: Amygdala kindling induces upregulation of mRNA for NKCC1, a Na+,K+-2Cl- cotransporter, in the rat piriform cortex. Neurosci Res 44: 225-229, 2002

7.Wang C, Shimizu-Okabe C, Watanabe K, Okabe A, Matsuzaki H, Ogawa T, Mori N, Fukuda A, Sato K: Developmental changes in KCC1, KCC2, and NKCC1 mRNA expressions in the rat brain. Dev Brain Res 139: 59-66, 2002

8.Shimizu-Okabe C, Yokokura M, Okabe A, Ikeda M, Sato K, Kilb W, Luhmann HJ, Fukuda A: Layer-specific expression of Cl- transporters and differential [Cl-]i in newborn rat cortex. Neuroreport 13: 2433-2437, 2002

9.Toyoda H, Ohno K, Okabe A, Ikeda M, Yamada J, Sato K, Hashimoto K, Fukuda A: Induction of NMDA and GABAA receptors-mediated Ca2+ oscillations with KCC2 mRNA downregulation in injured facial motoneurons. J Neurophysiol 89: 1344-1353, 2003

10.Takeuchi K, Fukuda A, Kanayama N: Effect of urinary trypsin inhibitor on potassium currents: fetus modulates membrane excitability by production of UTI. Acta Obster Gynecol Scand in press

山口 瞬(神戸大学・大学院医学系研究科)

1.Sumi Y, Yagita K, Yamaguchi S, Ishida Y, Kuroda Y, Okamura H: Rhythmic expression of ROR β mRNA in the mice suprachiasmatic nucleus. Neurosci Lett 320: 13-16, 2002

2.Ishida Y, Yokoyama C, Inatomi T, Yagita K, Dong X, Yan L, Yamaguchi S, Nagatsu I, Komori T, Kitahama K, Okamura H: Circadian rhythm of aromatic L-amino acid decarboxylase in the rat suprachiasmatic nucleus: gene expression and decarboxylating activity in clock oscillating cells. Genes Cells 7: 447-459, 2002

3.Onishi H, Yamaguchi S, Yagita K, Ishida Y, Dong X, Kimura H, Jing Z, Ohara H, Okamura H: Rev-erb alpha gene expression in the mouse brain with spatial emphasis on its circadian profiles in the suprachiasmatic nucleus. J Neurosci Res 68: 551-557, 2002

4.Terazono H, Mutoh T, Yamaguchi S, Kobayashi M, Akiyama M, Udo R, Ohdo S, Okamura H, Shibata S: Adrenergic regulation of clock gene expression in the mouse liver. Proc Natl Acad Sci USA in press

5.Sujino M, Masumoto K, Yamaguchi S, van der Horst GTJ, Okamura H, Inouye ST: Suprachiasmatic nucleus grafts restore circadian behavioral rhythms of genetically arrhythmic mice. Curr Biol in press

渡辺恭良(大阪市立大学・大学院医学研究科)

1.Imai-Matsumura K, Matsumura K, Terao A, Watanabe Y: Attenuated fever in pregnant rats is associated with blunted syntheses of brain cyclooxygenase-2 and PGE2. Am J Physiol Regul Integr Comp Physiol 283: R1346-1353, 2002

2.Shimakawa S, Suzuki S, Miyamoto R, Takitani K, Tanaka K, Tanabe T, Wakayama E, Nakamura F, Kuno M, Matsuura S, Watanabe Y, Tamai H: Neuropilin-2 is overexpressed in the rat brain after limbic seizures. Brain Res 95: 67-73, 2002

3.Cui YL, Kataoka Y, Li Q-H, Mochizuki T, Yokoyama C, Yamagata A, Mochizuki-Oda N, Watanabe J, Urade Y, Yamada H, Watanabe Y: Targeted tissue oxidation in the cerebral cortex induces local prolonged depolarization and cortical spreading depression in anesthetized and conscious rats. Biochem Biophys Res Commun 300: 631-636, 2003

4.Mizuma H, Mizutani M, Nozaki S, Iizuka H, Tohyama H, Nishimura N, Watanabe Y, Kohashi R: Improvement by repeated administration of 6R-tetrahydrobiopterin of 5,7-dihydroxytryptamine-induced abnormal behaviors in immature rats. Biochem Biophys Res Commun 302: 156-161, 2003


A01班
A02班
A03班
A04班
B01班
B02班
B03班
ゲノム班