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平成14年度
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B01班 |
三品昌美(東京大学・大学院医学系研究科) 1.Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S: Delphilin: a novel PDZ- and formin homology-domain containing protein, which synaptically colocalizes and interacts with glutamate receptor δ2 subunit. J Neurosci 22: 803-814, 2002 2.Takatsuki K, Kawahara S, Mori H, Mishina M, Kirino Y: Scopolamine impairs eyeblink conditioning in the cerebellar LTD-deficient mice. Neuroreport 13: 159-162, 2002 3.Haradahira T, Okauchi T, Maeda J, Zhang MR, Kida T, Kawabe K, Mishina M, Watanabe Y, Suzuki K, Suhara T: A positron-emitter labeled glycineB site antagonist, [11C]L-703,717, preferentially binds to a cerebellar NMDA receptor subtype consisting of GluRε3 subunits in vivo, but not in vitro. Synapse 43: 131-133, 2002 4.Miyamoto Y, Yamada K, Noda Y, Mori H, Mishina M, Nabeshima T: Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor ε4 subunit. J Neurosci 22: 2335-2342, 2002 5.Takeuchi T, Nomura T, Tsujita M, Suzuki M, Fuse T, Mori H, Mishina M: Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting. Biochem Biophys Res Commun 293: 953-957, 2002 6.Yoshida T, Ito A, Matsuda N, Mishina M: Regulation by protein kinase A switching of axonal pathfinding of zebrafish olfactory sensory neurons through the olfactory placode-olfactory bulb boundary. J Neurosci 22: 4964-4972, 2002 7.Sakamoto T, Mishina M, Niki H: Mutation of NMDA receptor subunit epsilon 1: Effects on audiogenic-like seizures induced by electrical stimulation of the inferior coliculus in mice. Mol Brain Res 102: 113-117, 2002 8.Uemura T, Mori H, Mishina M: Isolation and characterization of Golgi apparatus-specific GODZ with the DHHC zinc finger domain. Biochem Biophys Res Commun 296: 492-496, 2002 9.Ichikawa R, Miyazaki T, Kano M, Hashikawa T, Tatsumi H, Sakimura K, Mishina M, Inoue Y, Watanabe M: Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluRδ2. J Neurosci 22: 8487-8503, 2002 10.Takatsuki K, Kawahara S, Kotani S, Mori H, Mishina M, Kirino Y: Hippocampal damage disrupts eyeblink conditioning in mice lacking glutamate receptor δ2. J Biol Phys 28: 539-547, 2002 11.Tokuoka H, Yoshida T, Matsuda N, Mishina M: Regulation by glycogen synthase kinase-3β of the arborization field and maturation of retinotectal projection in zebrafish. J Neurosci 22: 10324-10332, 2002 12.Takatsuki K, Kawahara S, Kotani S, Fukunaga S, Mori H, Mishina M, Kirino Y: The hippocampus plays an important role in eyeblink conditioning with a short trace interval in glutamate receptor subunit δ2 mutant mice. J Neurosci 23: 17-22, 2003 13.Townsend M, Yoshii A, Mishina M, Constantine-Paton M: Developmental loss of miniature N-methyl-D-aspartate receptor currents in NR2A knockout mice. Proc Natl Acad Sci USA 100: 1340-1345, 2003 14.Fagiolini M, Katagiri H, Miyamoto H, Grant SGN, Mishina M, Hensch T: Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling. Proc Natl Acad Sci USA 100: 2854-2859, 2003 平野丈夫(京都大学・大学院理学研究科) 1.Kawaguchi S, Hirano T: Signaling cascade regulating long-term potentiation of GABAA receptor responsiveness in cerebellar Purkinje neurons. J Neurosci 22: 3969-3976, 2002 2.Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M: Delta/Notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem 277: 25400-25407, 2002 3.Fujii H, Hirano T: Calcineurin regulates induction of late phase of cerebellar long-term depression in rat cultured Purkinje neurons. Eur J Neurosci 16: 1777-1788, 2002 4.Minami I, Kengaku M, Sillevis Smitt P, Shigemoto R, Hirano T: Long-term potentiation of mGluR1 activity by depolarization-induced Homer1a in cerebellar Purkinje neurons. Eur J Neurosci in press 饗場 篤 (神戸大学・大学院医学系研究科) 1.Kishimoto Y, Fujimichi R, Araishi K, Kawahara S, Kano M, Aiba A, Kirino Y: mGluR1 in cerebellar Purkinje cells is required for normal association of temporally contiguous stimuli in classical conditioning. Eur J Neurosci 16: 2416-2424, 2002 2.Muto S, Aiba A, Saito Y, Nakao K, Nakamura K, Tomita K, Kitamura T, Kurabayashi M, Nagai R, Higashihara E, Harris PC, Katsuki M, Horie S: Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant. Hum Mol Genet 11: 1731-1742, 2002 3.Tabata T, Aiba A, Kano M: Extracellular calcium controls the dynamic range of neuronal metabotropic glutamate receptor responses. Mol Cell Neurosci 20: 56-68, 2002 井上貴文(東京大学・医科学研究所) 1.Yasuda H, Higashi H, Kudo Y, Inoue T, Hata Y, Mikoshiba K, Tsumoto T: Imaging of calcineurin activated by long-term depression-inducing synaptic inputs in living neurons of rat visual cortex. Eur J Neurosci 17: 287-297, 2003 2.Fukami K, Yoshida M, Inoue T, Kurokawa M, Fissore RA, Yoshida N, Mikoshiba K, Takenawa T: Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm. J Cell Biol in press 椛 秀人(高知医科大学・医学部) 1.Okutani F, Zhang JJ, Yagi F, Kaba H: Non-specific olfactory aversion induced by intrabulbar infusion of the GABAA receptor antagonist bicuculline in young rats. Neuroscience 112: 901-906, 2002 2.Zhang JJ, Okutani F, Inoue S, Kaba H: Activation of the cyclic AMP response element-binding protein signaling pathway in the olfactory bulb is required for the acquisition of olfactory aversive learning in young rats. Neuroscience 117: 707-713, 2003 久保義弘(東京医科歯科大学・大学院医歯学総合研究科) 1.Misaka T, Miyashita T, Kubo Y: Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization and effect on mitochondrial morphology. J Biol Chem 277: 15834-15842, 2002 2.Ai T, Fujiwara Y, Tsuji K, Otani H, Nakano S, Kubo Y, Horie M: Novel KCNJ2 mutation in familial periodic paralysis with ventricular dysrhythmia. Circulation 105: 2592-2594, 2002 3.Saitoh O, Murata Y, Odagiri M, Itoh M, Itoh H, Misaka T, Kubo Y: Alternative splicing of RGS8 gene determines inhibitory function of receptor-type-specific Gq signaling. Proc Natl Acad Sci USA 99: 10138-10143, 2002 4.Murata Y, Fujiwara Y, Kubo Y: Identification of a site involved in the block by extracellular Mg2+ and Ba2+ as well as permeation of K+ in Kir2.1 K+ channel. J Physiol 544: 665-677, 2002 5.Fujiwara Y, Kubo Y: Ser 165 in the second transmembrane region of the Kir2.1 channel determines its susceptibility to blockade by intracellular Mg2+. J Gen Physiol 120: 677-692, 2002 6.Abe H, Misaka T, Tateyama M, Kubo, Y: Effects of co-expression with Homer isoforms on the function of metabotropic glutamate receptor1a. Mol Cell Neurosci in press 小林和人(福島県立医科大学・医学部) 1.Matsushita N, Okada H, Yasoshima Y, Takahashi K, Kiuchi K, Kobayashi K: Dynamics of tyrosine hydroxylase promoter activity during midbrain dopaminergic neuron development. J Neurochem 82: 295-304, 2002 小林拓也(京都大学・大学院医学研究科) 1.Yoshida K, Oida H, Kobayashi T, Maruyama T, Tanaka M, Katayama T, Yamaguchi K, Segi, E, Tsuboyama T, Matsushita M, Ito K, Ito Y, Sugimoto Y, Ushikubi F, Ohuchida S, Kondo K, Nakamura T, Narumiya S: Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation. Proc Natl Acad Sci USA 99: 4580-4585, 2002 2.Kabashima K, Saji T, Murata T, Nagamachi M, Matsuoka T, Segi E, Tsuboi K, Sugimoto Y, Kobayashi T, Miyachi Y, Ichiawa A, Naumiya S: The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 109: 883-893, 2002 3.Kobayashi T, Narumiya S: Function of prostanoid receptors: studies on knockout mice. Prostaglandins Other Lipid Mediat 68-69: 557-573, 2002 4.Massiera F, Saint-Marc P, Seydoux J, Murata T, Kobayashi T, Narumiya S, Guesnet P, Amri EZ, Negrel R, Aihaud G: Arachidonic acid prostacyclin signaling promote adipose tissue development: a human health concern? J Lipid Res 44: 271-279, 2003 5.Matsuoka Y, Furuyashiki T, Bito H, Ushikubi F, Tanaka Y, Kobayashi T, Muro S, Satoh N, Kayahara T, Higashi M, Mizoguchi A, Shichi H, Fukuda Y, Nakao K, Narumiya S: Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. Proc Natl Acad Sci USA in press 6.Yurugi-Kobayashi T, Itoh H, Yamashita J, Yamahara K, Hirai H, Kobayashi T, Ogawa M, Nishikawa S, Nishikawa SI, Nakao K: Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage. Blood in press 齋藤尚亮(神戸大学・バイオシグナル研究センター) 1.Tada T, Uchino M, Nagai K, Nomura T, Kondoh T, Saito N, Yamamura T, Yajima Y, Nishizaki T: The anti-dementia drug FK960 stimulates glial glutamate release via a PKA pathway. Mol Brain Res 109: 63-68, 2002 2.Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H: PAR3β, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. Biochem Biophys Res Commun 299: 641-646, 2002 3.Larsen EC, Ueyama T, Brannock PM, Shirai Y, Saito N, Larsson C, Loegering D, Weber PB, Lennartz MR: Role for PKC-ε in FcγR-mediated phagocytosis by RAW 264.7 cells. J Cell Biol 159: 939-944, 2002 4.Irie K, Nakahara A, Nakagawa Y, Ohigashi H, Shindo M, Fukuda H, Konishi H, Kikkawa U, Kashiwagi K, Saito N: Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity. Pharmacol Therap 93: 271-281, 2002 5.Zhang X, Kuroda S, Carpenter D, Nishimura I, Soo C, Moats R, Iida K, Wisner E, Hu FY, Miao S, Beanes S, Dong C, Vastardis H, Longaker M, Tanizawa T, Kanayama N, Saito N, Ting K: Craniosynostosis in transgenic mice overexpressing Nell-1. J Clin Invest 110: 861-870, 2002 6.Irie N, Sakai N, Ueyama T, Kajimoto T, Shirai Y, Saito N: Subtype- and species-specific knockdown of PKC using short interfering RNA (siRNA). Biochem Biophys Res Commun 298: 738-743, 2002 7.Goerke A, Sakai N, Gutjahr E, Schlapkohl WA, Mushinski JF, Haller H, Kolch W, Saito N, Mischak H: Induction of apoptosis by Protein kinase C delta is independent of its kinase activity. J Biol Chem 277: 32054-32062, 2002 8.Ohta K, Nomura T, Kanno T, Nagai K, Yamamoto S, Yajima Y, Kondoh T, Kohmura E, Saito N Nishizaki T: L-trans-PDC enhances hippocampal neuronal activity by stimulating glial glutamate release independently of blocking transporters. Biochem Biophys Res Commun 295: 376-381, 2002 9.Tanimukai S, Hasegawa H, Nakai M, Yagi K, Hirai M, Saito N, Taniguchi T, Terashima A, Yasuda M, Kawamata T Tanaka C: Nanomolar amyloid β protein activates a specific PKC isoform mediating phosphorylation of MARCKS in Neuro2A cells. Neuroreport 13: 549-553, 2002 10.Kashiwagi K, Shirai Y, Kuriyama M, Sakai N, Saito N: Importance of C1B domain for lipid messenger-induced targeting of PKC. J Biol Chem 277: 18037-18045, 2002 11.Sakai K, Nakamura M, Sano A, Sakai N, Saito N: The silencer activity of the novel human serotonin transporter linked polymorphic region. Neurosci Lett 327: 13-16, 2002 12.Nishizaki T, Nagai K, Nomura T, Tada H, Kanno T, Tozaki H, Li XX, Kondoh T, Kodama N, Takahashi E, Sakai N, Tanaka K, Saito N: A new neuromodulatory pathway with a glial contribution mediated via A2a adenosine receptors. Glia 39: 133-147, 2002 13.Sawano A, Saito N, Miyawaki A: Multiple-colour fluorescence imaging Ca2+-calmodulin, protein kinase C, and their conflicting convergence on a shared target using novel epi-fluorescent microscopy. Biophys J 82: 1076-1085, 2002 14.Shindo M, Irie K, Masuda A, Ohigashi H, Shirai Y, Miyasaka K, Saito, N: Synthesis and phorbol ester binding of the cysteine-rich domains of diacylglycerol kinase (DGK) isozymes: DGKγ and DGKβ are new targets of tumor-promoting phorbol esters. J Biol Chem in press 15.Mogami H, Zhang H, Suzuki Y, Urano T, Saito N, Kojima I, Petersen OH: Decoding of short-lived Ca2+ influx signals into long-term substrate phosphorylation through activation of two distinct classes of protein kinase C. J Biol Chem in press 16.Sakai K, Hasegawa H, Okura M, Morikawa O, Ueyama T, Shirai Y, Sakai N, Saito, N: Novel variants of murine serotonin transporter mRNA and the promoter activity of its upstream sites. Neurosci Lett in press 田中秀和(大阪大学・大学院医学系研究科) 1.Do E, Taira E,Irie Y, Gan Y, Tanaka H, Kuo CH, and Miki N: Molecular cloning and characterization of rKAB1, which interacts with KARP-1, localizes in the nucleus and protects cells against oxidative death. Mol Cell Biochem in press 根本知己(岡崎国立共同研究機構・生理学研究所) 1.Takahashi N, Nemoto T, Kimura R, Tachikawa A, Miwa A, Okado H, Myashita Y, Iino M, Kadowaki T, Kasai H: Two-photon excitation imaging of pancreatic islets with various fluorescent probes. Diabetes 51: S25-S28, 2002 2.Takahashi N, Kishimoto T, Nemoto T, Kadowaki T, Kasai H: Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science 297: 1349-1352, 2002 3.Noda M, Yamashita S, Takahashi N, Eto K, Shen L, Izumi K, Daniel S, Tsubamoto Y, Nemoto T, Iino M, Kasai H, Sharp GW, Kadowaki T: Switch to anaerobic glucose metabolism with NADH accumulation in the b-cell model of mitochondrial diabetes: Characteristics of bHC9 cells deficient in mitochondrial DNA transcription. J Biol Chem 277: 41817-41826, 2002 渡辺雅彦(北海道大学・大学院医学研究科) 1.Miyagi Y, Yamashita T, Fukaya M, Sonoda T, Okuno T, Yamada K, Watanabe M, Nagashima Y, Aoki I, Okuda K, Mishina M, Kawamoto S: Delphilin: A novel PDZ- and Formin homology (FH)-domain containing protein, which interacts with glutamate receptor δ2 subunit. J Neurosci 22: 803-814, 2002 2.Oshima S, Fukaya M, Nagashima M, Shirakawa T, Oguchi H, Watanabe M: Early onset of NMDA receptor GluRε1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus. Neurosci Res 43: 239-250, 2002 3.Nakazawa K, Quirk MC, Chitwood RA, Watanabe M, Yeckel MF, Sun LD, Kato A, Carr CA, Jhonston D, Wilson MA, Tonegawa S: Requirement for hippocampal CA3 NMDA receptors in associative memory recall. Science 297: 211-218, 2002 4.Ichikawa R, Miyazaki T, Kano M, Hashikawa T, Tatsumi H, Sakimura K, Mishina M, Inoue Y, Watanabe M: Distal extension of climbing fiber territory and multiple innervation caused by aberrant wiring to adjacent spiny branchlets in cerebellar Purkinje cells lacking glutamate receptor GluRδ2. J Neurosci 22: 8487-8503, 2002 5.Miura M, Watanabe M, Offermanns S, Simon MI, Kano M: Group I mGluR signaling via G αq/G α11 secures the induction of long-term potentiation in the hippocampal area CA1. J Neurosci 22: 8379-8390, 2002 6.Toyooka K, Iritani S, Makifuchi T. Shirakawa O, Kitamura K, Maeda K, Nakamura R, Niizato K, Watanabe M, Kakita A, Takahashi H, Someya T, Nawa N: Selective reduction of a PDZ protein, SAP-97, in the prefrontal cortex of patients with chronic schizophrenia. J Neurochem 83: 797-806, 2002 7.Ohtsuki S, Tachikawa M, Takanaga H, Shimizu H, Watanabe M, Hosoya K, Terasaki T: The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J Cereb Blood Flow Metab 22: 1327-1335, 2002 8.Nakamura K, Tanoue K, Satoh T. Takekawa M, Watanabe M, Shima H, Kikuchi K: A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity. J Biochem 132: 463-470, 2002 9.Kinoshita M, Kojima S, Sato K, Watanabe M, Urano A, Ito E: Multiple-site optical recording for characterization of functional synaptic organization of the optic tectum of rainbow trout. Eur J Neurosci 16: 868-876, 2002 10.Sakai K, Shimizu H, Koike T, Furuya S, Watanabe M: Neutral amino acid transporter ASCT1 is preferentially expressed in L-Ser-synthetic/storing glial cells in the mouse with transient expression in developing capillaries. J Neurosci 23: 550-560, 2003 11.Kakizawa S, Yamada K, Watanabe M, Kano M: Effects of insulin-like growth factor I on climbing fiber synapse elimination during cerebellar development. Eur J Neurosci in press 12.Fukaya M, Kato A, Lovett C, Tonegawa S, Watanabe M: Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice. Proc Natl Acad Sci USA in press |
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