辻　省次（東京大学・大学院医学系研究科）

1.Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F: A new locus for Parkinson’s disease (PARK8) maps to chromosome 12p11.2-q13.1. Ann Neurol 51: 296-301, 2002

2.Takahashi T, Igarashi S, Kimura T, Hozumi I, Kawachi I, Onodera O, Takano H, Saito M, Tsuji S: Japanese cases of familial hemiplegic migraine with cerebellar ataxia carrying a T666M mutation in the CACNA1A gene. J Neurol Neurosurg Psychiat 72: 675-680, 2002

3.Toyoshima I, Sugawara M, Kato K, Wada C, Shimohata T, Koide R, Onodera O, Tsuji S: Time course of polyglutamine aggregate body formation and cell death: Enhanced growth in nucleus and an interval for cell death. J Neurosci Res 68: 442-448, 2002

4.Shimohata T, Sato A, Burke JR, Strittmatter WJ, Tsuji S, Onodera O: Expanded polyglutamine stretchers form an ‘aggresome’. Neurosci Lett 323: 215-218, 2002

5.Shimazaki H, Takiyama Y, Sakoe K, Ikeguchi K, Niijima K, Kaneko J, Namekawa M, Ogawa T, Date H, Tsuji S, Nakano I, Nishizawa M: early-onset ataxia with ocular motor apraxia and hypoalbuminemia. Neurology 59: 590-595, 2002

6.Arai A, Tanaka K, Igarashi S, Kobayashi H, Asaka T, Date H, Saito M, Tanaka H, Kawasaki S, Uyama E, Mizusawa H, Fukuhara N, Tsuji S: A novel mutation in the GNE gene and a linkage disequilibrium in Japanese pedigrees. Ann Neurol 52: 516-519, 2002

7.Silveria I, Miranda C, Guimarães L, Moreira M-C, Alonso I, Mendonça P, Ferro,A, Pinto-Basto J, Coelho J, Ferreirinha F, Poirier J, Parreira E, Vale J, Januário C, Barbot C, Tuna A, Barros J, Koide R, Tsuji S, Holmes SE, Margolis RL, Jardim L, Pandolfo M, Coutinho P, Sequeiros J: Trinucleotide repeats in 202 families with ataxia. A small expanded (CAG)n allele at the SCA17 locus. Arch Neurol 59: 623-629, 2002

8.Tanaka M, Tanaka K, Nakano R, Inuzuka T, Tsuji S, Shinozawa K, Kojo T, Matsui T, Kumamoto T, Suzumura A: HLA antigens in Japanese patients with anti-Hu antibodies. Neurology in press

9.Yamada M, Tsuji S, Takahashi H: Involvement of lysosomes in the pathogenesis of CAG-repeat diseases. Ann Neurol in press

岩坪 威（東京大学・大学院薬学系研究科）

1.Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DMA, Iwatsubo T: CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV. EMBO J 21: 1524-1534, 2002

2.Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H: Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51: 525-530, 2002

3.Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T: Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4. J Biol Chem 277: 14965-14975, 2002

4.Miake H, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002

5.Tomita T, Katayama R, Takikawa R, Iwatsubo T: Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments. FEBS Lett 520: 117-121, 2002

6.Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Haass C, Takeda M: Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1. EMBO J 21: 5408-5416, 2002

7.Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice and in Lewy body disease patients. J Clin Invest 110: 1429-1439, 2002

8.Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann DMA, Iwatsubo T: Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002

9.Takasugi N, Takahashi Y, Morohashi Y, Tomita T, Iwatsubo T: The mechanism of γ-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals. J Biol Chem 277: 50198-50205, 2002

10.Takahashi M, Kanuka H, Fujiwara H, Koyama A, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila. Neurosci Lett 336: 155-158, 2003

11.Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature in press

祖父江　元（名古屋大学・大学院医学系研究科）

1.Koike H, Misu K, Ikeda S, Ando Y, Nakazato M, Ando E, Yamamoto M, Hattori N, Sobue G: Type I (transthyretin Met30) familial amyloid polyneuropathy in Japan: early- vs late-onset form. Arch Neurol 59: 1771-1776, 2002

2.Yoshihara T, Ishigaki S, Yamamoto M, Liang Y, Niwa J, Takeuchi H, Doyu M, Sobue G: Differential expression of inflammation-and apoptosis-related genes in spinal cords of a mutant SOD1 trangenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem 80: 158-167, 2002

3.Mori K, Hattori N, Sygiura M, Koike H, Misu K, Ichimura M, Hirayama M, Sobue G: Chronic inflammatory demyelinating polyneuropathy presenting with features of GBS. Neurology 58: 979-982, 2002

4.Ikeda S, Nakazato M, Ando Y, Sobue G: Familial transthyretin-type amyloid polyneuropathy in Japan. Neurology 58: 1001-1007, 2002

5.Watanabe H, Saito Y, Terao S, Ando T, Kachi T, Mukai E, Aiba K, Abe Y, Tamakoshi A, Doyu M, Hirayama M, Sobue G: Progression and prognosis in multiple system atrophy. An analysis of 230 Japanese patients. Brain 125: 1070-1083, 2002

6.Ishigaki S, Liang Y, Yamamoto M, Niwa J, Ando Y, Yoshihara T, Takeuchi H, Doyu M, Sobue G: X-linked inhibitor of apoptosis protein is involved in mutant SOD-1 mediated neuronal degeneration. J Neurochem 82: 576-584, 2002

7.Katsuno M, Adachi H, Kume A, Li M, Nakagomi Y, Niwa H, Sang C, Kobayashi Y, Doyu M, Sobue G: Teststerone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy. Neuron 35: 843-854, 2002

8.Niwa J, Ishigaki S, Hishikawa N, Yamamoto M, Doyu M, Murata S, Tanaka K, Taniguchi N, Sobue G: Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem 277: 36793-36798, 2002

9.Takeuchi H, Kobayashi Y, Ishigaki S, Doyu M, Sobue G: Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem 277: 50966-50972, 2002

10.Hattori N, Yamamoto M, Yoshihara T, Koike H, Nakagawa N, Yoshikawa H, Ohnishi A, Hayasaka K, Onodera O, Baba M, Yasuda H, Saito T, Nakashima K, Kira J, Kaji R, Oka N, Sobue G and the Study Group for Hereditary Neuropathy in Japan: Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients. Brain 126: 134-151, 2003

11.Koike H, Iijima M, Sugiura M, Mori K, Hattori N, Ito H, Hirayama M, Sobue G: Alcoholic neuropathy is clinicopathologically distinct from thiamine-deficiency neuropathy. Ann Neurol in press

12.Adachi H, Katsuno M, Minamiyama M, Sang C, Pagoulatos G, Kobayashi Y, Doyu M, Sobue G: HSP70 chaperone over-expression ameliorates phenotypes of the SBMA transgenic mouse model by reducing nuclear-localized mutant AR protein. J Neurosci in press

水野美邦（順天堂大学・医学部）

1.Hyun DH, Lee M, Hattori N, Kubo S, Mizuno Y, Halliwell B, Jenner P: Effect of wild-type or mutant Parkin on oxidative damage, nitric oxide, antioxidant defenses, and the proteasome. J Biol Chem 277: 28572-28577, 2002

2.Kobayashi K, Mori H, Okuma Y, Dickson DW, Cookson N, Tsuboi Y, Motoi Y, Tanaka R, Miyashita N, Anno M, Narabayashi H, Mizuno Y: Contrasting genotypes of the tau gene in two phenotypically distinct patients with P301L mutation of frontotemporal dementia and Parkinsonisn linked to chromosome 17. J Neurol 249: 669-675, 2002

3.Miwa H, Mizuno Y: Enlargements of somatosensory-evoked potentials in progressive supranuclear palsy. Acta Neurol Scand 106: 209-212, 2002

4.Miwa H, Kondo T, Mizuno Y: Bell's palsy-induced blepharospasm. J Neurol 249: 452-454, 2002

5.Miwa H, Mizuno Y, Kondo T: Familial hemifacial spasm: report and cases and review of literature. J Neurol Sci 193: 97-102, 2002

6.Mori H, Oda M, Komori T, Arai N, Takanashi M, Mizutani T, Hirai S, Mizuno Y: Lewy bodies in progressive supranuclear palsy. Acta Neuropathol 104: 273-278, 2002

7.Ohizumi H, Okuma Y, Fuake J, Fujishima K, Goto K, Mizuno Y: Head tremor in dentatorubral-pallidoluysian atrophy. Acta Neurol Scand 106: 319-321, 2002

8.Okuma Y, Mizuno Y, Lee RG: Reciprocal Ia inhibition in patients with asymmetric spinal spasticity. Clin Neurophysiol 113: 292-297, 2002

9.Schlossmacher MG, Frosch MP, Gai WP, Medina M, Sharma N, Forno L, Ochiishi T, Shimura H, Sharon R, Hattori N, Langston JW, Mizuno Y, Hyman BT, Selkoe DJ, Kosik KS: Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol 160: 1655-1667, 2002

10.Suzuki A, Obi K, Urabe T, Hayakawa H, Yamada M, Kaneko S, Onodera Y, Mizuno Y, Mochizuki H: Feasibility of ex vivo gene therapy for neurological disorders using the new retroviral GCDNsap packaged in the vesicular stomatitis virus G protein. J Neurochem 82: 953-960, 2002

11.Takanashi M, Ohta S, Matsuoka S, Mori H, Mizuno Y: Mixed multiple system atrophy and progressive supranuclear palsy: a clinical and pathological report of one case. Acta Neuropathol 103: 82-87, 2002

12.Tanaka R, Mochizuki H, Suzuki A, Katsube N, Ishitani R, Mizuno Y, Urabe T: Induction of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in rat brain after focal ischemia/reperfusion. J Cereb Blood Flow Metab 22: 280-288, 2002

13.The Global Parkinson’s Disease Survey (GPDS) Steering Committee. Factors Impacting on quality of life in Parkinson’s disease. Results from an international survey. Mov Disord 17: 60-67, 2002

14.Urabe T, Tanaka R, Noda H, Mizuno Y: Anticoagulant therapy with a selective thrombin inhibitor for acute cerebral infarction: usefulness of coagulation markers for evaluation of efficacy. J Thrombosis 13: 155-160, 2002

15.Kobayashi H, Krüger R, Markopoulou K, Wszolek Z, Chase B, Taka H, Mineki R, Murayama K, Riess O, Mizuno Y, Hattori N: Haploinsufficiency at the α-synuclein gene underlies phenotypic severity in familial Parkinson's disease. Brain in press

16.Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M,Mizuno Y, Mori H: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology. Ann Neurol in press

17.Mori H, Hattori N, Mizuno Y: Genotype-phenotype correlation: Familial Parkinson disease. Neuropathology in press

18.Takanashi M, Mori H, Arima K, Mizuno Y, Hattori N: Expression patterns of tau mRNA isoforms correlate with susceptible lesions in progressive supranuclear palsy and corticobasal degeneration. Mol Brain Res in press

19.Tanaka R, Komine-Kobayashi M, Mochizuki H, Yamada M, Furuya T, Migita M, Shimada T, Mizuno Y, Urabe T: Migration of EGFP expressing bone marrow-derived microglia/macrophage into the mice brain following permanent focal ischemia. Neuroscience in press

青木正志（東北大学・医学部）

1.Tateyama M, Aoki M, Nishino I, Hayashi YK, Sekiguchi S, Shiga Y, Takahashi T, Onodera Y, Haginoya K, Kobayashi K, Iinuma K, Nonaka I, Arahata K, Itoyama Y: Mutation in the caveolin-3 gene causes a peculiar form of distal myopathy, Neurology 58: 323-325, 2002

2.Saito A, Higuchi I, Nakagawa M, Saito M, Hirata K, Suehara M, Yoshida Y, Takahashi T, Aoki M, Osame M: Miyoshi myopathy patients with novel 5' splicing donor site mutations showed different immunostaining at sarcolemma, Acta Neuropathol 104: 615-620, 2002

3.Nishino I, Noguchi S, Murayama K Driss A, Sugie K, Oya Y, Nagata T, Chida K, Takahashi T, Takusa Y, Ohi T, Nishimaya J, Sunohara N, Ciafaloni E, Kawai M, Aoki M, Nonaka I: Distal myopathy with rimmed vacuoles is allelic to hereditary inclusion body myopathy. Neurology 59: 1689-1693, 2002

4.Takahashi T, Aoki M, Tateyama M, Kondo E, Mizuno T, Onodera Y, Takano R, Kawai H, Kamakura K, Mochizuki H, Shizuka-Ikeda M, Nakagawa M, Yoshida Y, Akanuma J, Hoshino K, Saito H, Nishizawa M, Kato S, Saito K, Miyachi T, Yamashita H, Kawai M, Matsumura T, Kuzuhara S, Ibi T, Sahashi K, Nakai H, Kohnosu T, Nonaka I, Arahata K, Brown RH Jr, Saito H, Itoyama Y: Dysferlin mutations in Japanese Miyoshi myopathy: Relationship to phenotype. Neurology in press

石川欽也（東京医科歯科大学・医学部）

1.Li M, Ishikawa K, Toru S, Tomimitsu H, Takashima M, Goto J, Takiyama Y, Sasaki H, Imoto I, Inazawa J, Toda T, Kanazawa I, Mizusawa H: Physical map and haplotype analysis of 16q-linked autosomal dominant cerebellar ataxia (ADCA) type III in Japan. J Hum Genet 48: 111-118, 2003

2.Tomimitsu H, Ishikawa K, Shimizu J, Ohkoshi N, Kanazawa I, Mizusawa H: Distal myopathy with rimmed vacuoles: novel mutations in the GNE gene. Neurology 59: 451-454, 2002

3.Kubodera T, Yokota T, Owada K, Ishikawa K, et al: Proteolytic cleavage and cellular toxicity of human α1A-calcium channel in spinocerebellar ataxia type 6. Neurosci Lett in press

大野耕策（鳥取大学・医学部）

1.Sakuraba H, matsuzawa F, Aikawa S, Doi H, Kotani M, Lin H, Ohno K, Tanaka A, Yamada H, Uyama E: Molecular and structural studies of the GM2 gangliosidosis O variants. J Hum Genet 47: 176-183, 2002

2.Yamamoto T, Pipo JR, Feng J-H, Takeda H, Nanba E, Ninomiya H, Ohno K: Novel TSC1 and TSC2 mutations in Japanese patients with tuberous sclerosis complex. Brain Dev 24: 227-230, 2002

3.Saito Y, Suzuki K, Nanba E, Yamamoto T, Ohno K, Murayama S: Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid β deposition associated with ApoE ε4 hmomozygosity. Ann Neurol 52: 351-355, 2002

4.Kobayshi S, Ohno K, Kaneda Y, Saji M: Synaptotagmin I hypoythalamic knockdown prevents amygdaloid seizure-induced damage of hippocampal neurons but not of entorhinal neurons. Neurosci Res 44: 455-65, 2002

5.Sampei M, Kimura K, Ohno K, Ikawa S, Yamada K: Dioxins and fatty acids in breast milk from promiparas in Yanago district, Tottori prefecture, Japan. Yonago Acta Med 45: 103-111, 2002

6.Iwakuma M, Anzai T, Kobayashi S, Ogata M, Kaneda Y, Ohno K, Saji M: Antisense in vivo knockdown of synaptotagmin I and synapsin I by HVJ-liposome mediated gene transfer modulates ischemic injury of hippocampus in opposing ways. Neurosci Res 45: 285-96, 2003

郭　伸（東京大学・大学院医学系研究科）

1.Yoshimura M, Yamamoto T, Sone-Isoo N, Imafuku I, Momose T, Shirouzu I, Kwak S, Kanazawa I: Hemiparkinsonism in a patient with a mesencephalic tumor. J Neurol Sci 197: 89-92, 2002

2.Yamamoto Y, Hidaka I, Isoo N, Komai A, Soma R, Kwak S: Noise-based compensation for postural hypotension in primary autonomic failure. Brain Res 945: 71-78, 2002

3.Kawahara Y, Kwak S, Sun H, Ito K, Hashida H, Aizawa H, Jeong S-Y, Kanazawa I: Human spinal motoneurons express low relative abundance of GluR2 mRNA: An implication for excitotoxicity in ALS. J Neurochem in press

木村洋子（東京都臨床医学総合研究所）

1.Kimura Y, Koitabashi S, Kakizuka A, Fujita T: Circumvention of chaperone requirement for aggregate formation of a short polyglutamine tract by the co-expression of a long polyglutamine tract. J Biol Chem 277: 37536-37541, 2002

2.Matsumoto S, Tanaka E, Nemoto T, Ono T, Takagi T, Imai J, Kimura Y, Yahara I,  Kobayakawa T, Ayuse T, Oi K, Mizuno A: Interaction between the N-terminal and middle regions is essential for the in vivo function of HSP90 molecular chaperone. J Biol Chem 277: 34959-34966, 2002

木山博資（大阪市立大学・大学院医学研究科）

1.Kato R, Kiryu-Seo S, Kiyama H: Damage induced neuronal endopeptidase (DINE/ECEL) expression is regulated by LIF and deprivation of NGF in rat sensory ganglia after nerve injury. J Neurosci 22: 9410-9418, 2002

2.Aoki S, Su QN, Hang L, Nishikawa K, Ayukawa K, Hara Y, Namikawa K, Kiryu-Seo S, Kiyama H, Wada K: Identification of a novel axotomy-induced glycosylated protein, AIGP1, possibly involved in cellular apoptosis triggered by ER-Golgi stress. J Neurosci 22: 10751-10760, 2002

3.Honma M, Namikawa K, Mansur K, Iwata T, Mori N, Iizuka H, Kiyama H: Developmental alteration of nerve injury induced glial cell line-derived neurotrophic factor (GDNF) receptor expression is crucial for the determination of injured motoneuron fate. J Neurochem 82: 961-976, 2002

4.Iwata T, Namikawa K, Honma M, Mori N, Yachiku S, Kiyama H: Increased expression of mRNAs for microtubule disassembly molecules during nerve regeneration. Mol Brain Res 102: 105-109, 2002

5.Takamiya A, Takeda M, Yoshida A, Kiyama H: Inflammation induces serine protease inhibitor 3 (SPI-3) expression in the rat pineal gland. Neuroscience 113: 387-394, 2002

6.Takeda M, Takamiya A, Yoshida A, Kiyama H: Extracellular signal-regulated kinase activation predominantly in Muller cells of retina with endotoxin-induced uveitis. Invest Ophth Vis Sci 43: 907-911, 2002

亀高　諭（大阪大学・大学院医学系研究科）

1.Kametaka S, Shibata M, Moroe K, Kanamori S, Ohsawa Y, Waguri S, Sims PJ, Emoto K, Umeda M, Uchiyama Y: Identification of phospholipid scramblase 1 as a novel interacting molecule with β-secretase (BACE). J Biol Chem in press

下濱　俊（京都大学・大学院医学研究科）

1.Yamamoto K, Hashimoto K, Nakano M, Shimohama S, Kato N: A distinct form of calcium release down-regulates membrane excitability in neocortical pyramidal cells. Neuroscience 109: 665-676, 2002

2.Yamamoto K, Nakano M, Hashimoto K, Shimohama S, Kato N: Emergence of a functional coupling between insotol-1,4,5-trisphosphate receptors and calcium channels in developing neocortical pyramidal neurons. Neuroscience 109: 677-685, 2002

3.Castellani RJ, Perry G, Siedlak SL, Nunomura A, Shimohama S, Zhang J, Montine T, Sayre LM, Smith MA: Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies. Neurosci Lett 319: 25-28, 2002

4.Wataya T, Nunomura A, Smith MA, Siedlak SL, Harris PLR, Shimohama S, Szweda LI, Kaminski MA, Price DL, Cleveland DW, Sayre LM, Perry G: High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal. J Biol Chem 277: 4644-4648, 2002

5.Kume T, Asai N, Nishikawa H, Mano N, Terauchi T, Taguchi R, Shirakawa H, Osakada F, Mori H, Asakawa N, Yonaga M, Nishizawa Y, Sugimoto H, Shimohama S, Katsuki H, Kaneko S, Akaike A: Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum. Proc Natl Acad Sci USA 99: 3288-3293, 2002

6.Kakimura J-I, Kitamura Y, Umeki M, Suzuki S, Shibagaki K, Taniguchi T, Nomura Y, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins. FASEB J 16: 601-603, 2002

7.Kawamata J, Shimohama S: Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer’s disease. J Alz Dis 4: 71-76, 2002

8.Sawada H, Ibi M, Kihara T, Honda K, Nakanishi M, Sakka N, Akaike A, Shimohama S: Estradiol protects dopaminergic neurons in a MPP⁺ Parkinson^,s disease model Neuropharmacology 42: 1056-1064, 2002

9.Tsuji T, Shimohama S: Protein degradation in Alzheimer^’s disease and aging of the brain. Prog Mol Subcell Biol 29: 43-60, 2002

10.Kihara T, Shimohama S, Sawada H, Honda K, Nakamizo T, Kanki R, Yamashita H, Akaike A: Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade. J Neurosci Res 70: 274-282, 2002

11.Kitamura Y, Inden M, Miyamura A, Kakimura J, Taniguchi T, Shimohama S: Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells. Neurosci Lett 333: 25-28, 2002

12.Tsuji T, Shiozaki A, Kohno R, Yoshizato K, Shimohama S: Proteomic profiling and neurodegeneration in Alzheimer^,s disease. Neurochem Res 27: 1245-1253, 2002

13.Kakimura J, Kitamura Y, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Possible involvement of ER chaperone GRP78 on reduced formation of amyloid-β deposits. Ann N Y Acad Sci 977: 327-332, 2002

14.Takata K, Kitamura Y, Kakimura J, Shibagaki K, Taniguchi T, Gebicke-Haerter PJ, Smith MA, Perry G, Shimohama S: Possible protective mechanisms of heme oxygenase-1 in the brain. Ann N Y Acad Sci 977: 501-506, 2002

15.Perry G, Nunomura A, Cash AD, Taddeo MA, Hirai K, Akiev G, Avila J, Wataya T, Shimohama S, Atwood CS, Smith MA: Reactive oxygen: its sources and significance in Alzheimer disease. J Neural Transm 62: 69-75, 2002

16.Perry G, Taddeo M, Nunomura A, Zhu X, Zenteno-Savin T, Drew K, Shimohama S, Avila J, Castellani RJ, Smith MA: Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response. Comp Biochem Physiol C Toxicol Pharmacol 133: 507-513, 2002

17.Kitamura Y, Taniguchi T, Shimohama S, Akaike A, Nomura Y: Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists. Neurochem Res 28: 1035-1040, 2003

18.Nakamizo T, Kawamata J, Yoshida K, Kawai Y, Kanki R, Sawada H, Kihara T, Yamashita H, Shibasaki H, Akaike A, Shimohama S: Phosphodiesterase (PDE) inhibitors are neuroprotective to cultured motor neurons. J Neurosci Res 71: 485-495, 2003

19.Kitamura Y, Ishida Y, Takata K, Mizutani H, Kakimura J, Inden M, Nakata J, Taniguchi T, Tsukahara T, Akaike A, Shimohama S: Hyperbilirubinemia protects against focal ischemia in rats. J Neurosci Res 71: 544-550, 2003

20.Takata K, Kitamura Y, kakimura J, Shibagaki K, Tsuchiya D, Taniguchi T, Smith MA, Perry G, Shimohama S: Role of high mobility group protein-1 (HMG1) in amyloid-β homeostasis. Biochem Biophys Res Commun 301: 699-703, 2003

21.Kitagawa N, Shimohama S, Oeda T, Uemura K, Kohno R, Kuzuya A, Shibasaki H, Ishii N: The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. J Biol Chem in press

22.Kitamura Y, Shibagaki K, Takata K, Tsuchiya D, Taniguchi T, Gebicke-Haerter PJ, Miki H, Takenawa T, Shimohama S: Involvement of WAVE and Rac1 in the phagocytosis of amyloid-β (1-42) in rat microglia. J Pharmacol Sci in press

鈴木俊顕（東京都臨床医学総合研究所・分子腫瘍学研究部門）

1.Yoshida Y, Chiba T, Tokunaga F, Kawasaki H, Iwai K, Suzuki T, Ito Y, Matsuoka K, Yoshida M, Tanaka K, Tai T: E3 ubiquitin ligase that recognizes sugar chains. Nature 148: 438-442, 2002

2.Kadoya T, Yamamoto H, Suzuki T, Yukita A, Fukui A, Michiue T, Asahara T, Tanaka K, Asashima M, Kikuchi A: Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of β-catenin. Mol Cell Biol 22: 3803-3819, 2002

3.Ogawara Y, Kishishita S, Obata T, Isazawa Y, Suzuki T, Tanaka K, Masuyama N, Gotoh Y: Akt enhances Mdm2-mediated ubiquitination and degradation of p53. J Biol Chem 277: 21843-21850, 2002

程　久美子（東京大学・大学院理学系研究科）

1.Hamada T, Ui-Tei K, Imaki J, Takahashi F, Onodera H, Mishima T, Miyata Y: The expression of SCDGF/PDGF-C/fallotein and SCDGF-B/PDGF-D in the rat central nervous system. Mech Dev 112: 161-164, 2002

2.Uwo MF, Ui-Tei K, Park P, Takeda M: Replacement of midgut epithelium in the greater wax moth, Galleria mellonela, during larval-pupal moult. Cell Tissue Res 308: 319-331, 2002

3.Seike M, Gemma A, Hosoya Y, Hosomi Y, Okano T, Kurimoto F, Uematsu K, Takenaka K, Yoshimura A, Shibuya M, Ui-Tei K, Kudoh S: The promoter region of the human BUBR1 gene and its expression analysis in lung cancer. Lung Cancer 38: 229-234, 2002

4.Doi N, Zenno S, Ueda R, Ohki-Hamazaki H, Ui-Tei K, Saigo K: Short-Interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. Curr Biol 13: 41-46, 2003

5.Iwabushi M, Ui-Tei K, Yamada K, Matsuda Y, Sakai Y, Tanaka K, Ohki-Hamazaki H: Molecular cloning and characterization of avian bombesin-like peptide receptors: New tools for investigating molecular basis for ligand selectivity. Br J Pharmacol in press

永井義隆（大阪大学・大学院医学系研究科）

1.Tachikawa M, Nagai Y, Nakamura K, Kobayashi K, Fujiwara T, Han HJ, Nakabayashi Y, Ichikawa Y, Goto J, Kanazawa I, Nakamura Y, Toda T: Identification of CAG repeat-containing genes expressed in human brain as candidate genes for autosomal dominant spinocerebellar ataxias and other neurodegenerative diseases. J Hum Genet 47: 275-278, 2002

2.Azuma T, Uemichi T, Funauchi M, Nagai Y, Matsubara T: Ambulatory blood pressure monitoring in patients with spinocerebellar degeneration. Acta Neurol Scand 106: 213-217, 2002

中村浩一郎（東京大学・大学院医学系研究科）

1.Hazeki N, Tsukamoto T, Yazawa I, Koyama M, Hattori S, Someki I, Iwatsubo T, Nakamura K, Goto J, Kanazawa I: Ultrastructure of nuclear aggregates formed by expressing an expanded polyglutamine. Biochem Biophys Res Commun 294: 429-440, 2002

高橋良輔（理化学研究所・脳科学総合研究センター）

1.Imai Y, Soda M, Hatakeyama S, Akagi T, Hashikawa T, Nakayama K-I, Takahashi R: CHIP is associated with Parkin, a gene responsible for familial Parkinson‘s disease, and enhances its ubiquitin ligase activity. Mol Cell 10: 55-67, 2002

2.Kobayashi S, Yamashita K, Takeoka T, Ohtsuki T, Suzuki Y, Takahashi R, Yamamoto K, Kaufmann SH, Uchiyama T, Sasada M, Takahashi A: Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia. J Biol Chem 277: 33968-33977, 2002

3.Urushitani U, Kurisu J, Tsukita K, Takahashi R: Proteasomal inhibition　by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J Neurochem. 83: 1030-1042, 2002

4.Yang Y, Nishimura I, Imai Y, Takahashi R, Lu B: Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron in press

貫名信行（理化学研究所・ 脳科学総合研究センター）

1.Mitsui K, Nakayama H, Akagi T, Nekooki M, Ohtawa K, Takio K, Hashikawa T, Nukina N: Purification of polyglutamine aggregates and identification of elongation factor-1α and heat shock protein 84 as aggregate-interacting proteins. J Neurosci 22: 9267-9277, 2002

2.Tanaka M, Machida Y, Nishikawa Y, Akagi T, Morishima I, Hashikawa T, Fujisawa T, Nukina N: The effects of aggregation-inducing motifs on amyloid formation of model proteins related to neurodegenerative diseases. Biochemistry 41: 10277-10286, 2002

3.Park TJ, Hamanaka H, Ohshima T, Watanabe N, Mikoshiba K, Nukina N: Inhibition of ubiquitin ligase Siah-1A by disabled-1. Biochem Biophys Res Commun 302: 671-678, 2003

4.Lee JA, Lim CS, Lee SH, Kim H, Nukina N, Kaang BK: Aggregate formation and the impairment of long-term synaptic facilitation by ectopic expression of mutant huntingtin in Aplysia neurons. J Neurochem in press

長谷川一子（国立相模原病院・神経内科）

1.Funayama M, Hasegawa K, Kowa H, Saito M, Tsuji S, Obata F: A new locus for Parkinson's disease (Park8) maps to chromosome 12p11.2-q13.1. Ann Neurol 51: 296-301, 2002

久永真市（東京都立大学・理学研究科）

1.Alim MA, Hossain MS, Arima K, Takeda K, Izumiyama Y, Nakamura M, Kaji H, Shinoda T, Hisanaga S, Ueda K: Tubulin seeds α-synuclein fibril formation. J Biol Chem 272: 2112-2117, 2002

2.Iida J, Itoh TJ, Hotani H, Nishiyama K, Murofushi H, Bulinski JC, Hisanaga S: The projection domain of MAP4 suppresses the microtubule-bundling activity of the microtubule-binding domain. J Mol Biol 320: 97-106, 2002

3.Sasaki T, Taoka M, Ishiguro K, Uchida A, Saito T, Isobe T, Hisanaga S: In vivo and in vitro phosphorylation at Ser493 in the E-segment of neurofilament-H subunit by GSK3β. J Biol Chem 277: 36032-36039, 2002

4.Hashiguchi M, Saito T, Hisanaga S, Hashiguchi T: Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau 40. J Biol Chem 277: 44524-44530, 2002

5.Saito T, Onuki R, Fujita Y, Kusakawa G, Ishiguro K, Bibb JA, Kishimoto T, Hisanaga S: Developmental regulation of the proteolysis of the p35 Cdk5 activator by phosphorylation. J Neurosci in press

6.Takahashi S, Saito T, Hisanaga S, Pant HC, Kulkarni AB: Tau phosphorylation by cyclin-dependent kinase 5/p39 during brain development reduces its affinity for microtubules. J Biol Chem in press

船越　洋（大阪大学・大学院医学系研究科）

1.Funakoshi H, Yonemasu T, Nakano T, Matsumoto K, Nakamura T: Identification of Gas6, a putative ligand for Sky and Axl receptor tyrosine kinases, as a novel neurotrophic factor for hippocampal neurons. J Neurosci Res. 68: 150-160, 2002

2.Kishi Y, Funakoshi H, Matsumoto K, and Nakamura T: Molecular cloning, expression and partial characterization of Xksy, Xenopus member of the Sky family of receptor tyrosine kinases. Gene 288: 29-40, 2002

3.Sun W, Funakoshi H, Nakamura T: Localization and functional role of hepatocyte growth factor (HGF) and its receptor c-met in the rat developing cerebral cortex. Mol Brain Res 103: 36-48, 2002

4.Sun W, Funakoshi H, Nakamura T: Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci 22: 6537-6548, 2002

5.Funakoshi H, Nakamura T: Hepatocyte growth factor: from diagnosis to clinical applications. Clin Chim Acta 327: 1-23, 2003

堀江秀典（早稲田大学・先端バイオ研究所）

1.Takano M, Horie H, Iijima Y, Dezawa M, Sawada H, Ishikawa Y: Brain-derived neurotrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitro. Exp Eye Res 74: 319-323, 2002

2.Saito H, Sango K, Horie H, Takeshita K, Ikeda H, Ishigatsubo Y, Ishikawa Y: Trachea enhances neurite regeneration from adult rat nodose ganglia in vitro. Life Sci 70: 1935-1946, 2002

3.Nishioka T, Sakumi K, Miura T, Tahara K, Horie H, Kadoya T, Nakabeppu Y: FosB gene products trigger cell proliferation and morphological alteration with an increased expression of a novel processed form of galectin-1 in the rat 3Y1 embryo cell line. J Biochem 131: 653-661, 2002

4.Oshitari T, Dezawa M, Okada S, Takano M, Negishi h, Horie H, Sawada H, Tokuhisa T, Adachi-Usami E: Suppression of c-fos mediates inhibition of cell death and increases neurite regeneration in retinal ganglion cells. Invest Ophthalmol Vis Sci 43: 2442-2449, 2002

5.Sango K, Horie H, Saito H, Ajiki K, Tokashiki A, Takeshita K, Ishigatsubo Y, Kawano H, Ishikawa Y: Diabetes is not a potent inducer of neuronal cell death in mouse sensory ganglia, but it enhances neurite regeneration in vitro. Life Sci 71: 2351- 2368, 2002

6.Fukaya K, Hasegawa M, Kadoya T, Horie H, Fujisawa H, Hayashi Y, Tachibana O, Kida S, Yamashita J: Oxidized galectin-1 stimulates the migration of Schwann cells from both proximal and distal stumps of transected nerves and promotes axonal regeneration after peripheral nerve injury. J Neuropath Exp Neurrol. 62: 162-172, 2003

7.Tahara K, Tsuchimoto D, Tominaga Y, Asoh S, Ohta S, Kitagawa M, Horie H, Kadoya T, Nakabeppu Y: ΔFosB induces the delayed apoptosis independent of cell proliferation of the Rat1a embryo cell line. Cell Death Differ in press

水澤英洋（東京医科歯科大学・大学院医歯学総合研究科）

1.Tsunemi T, Saegusa H, Ishikawa K, Nagayama S, Murakoshi T, Mizusawa H, Tanabe T: Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca²⁺ current. J Biol Chem 277: 7214 -7221, 2002

2.Miake H, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002

3.Ohara S, Iwahashi T, Oide T, Hayashi R, Nakajima T, Ishikawa K, Mizusawa H: Spinocerebellar ataxia type6 with motor neuron loss: A follow-up autopsy report. J Neurol 294: 633-635, 2002

4.Kubodera T, Yokota T, Ohwada K, Ishikawa K, Miura H, Matsuoka T, Mizusawa H: Proteolytic cleavage and cellular toxicity of the human α1A calcium channel in spinocerebellar ataxia type 6 (SCA6). Neurosci Lett in press

村本　環（東北大学・大学院医学系研究科）

1.Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, Kitamoto N, Itohara S, Kasai N, Katsuki M, Higuchi J, Muramoto T, Shin R-W: Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem Biophys Res Commun 294: 280-286, 2002