井原康夫（東京大学・大学院医学系研究科）

1.Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, Ihara Y, Goshima Y, Suh PG, Ryu SH: Collapsin response mediator protein-2 inhibits neuronal phospholipase D2 activity by direct interaction. J Biol Chem 277: 6542-6549, 2002

2.Qi Y, Morishima-Kawashima M, Sato T, Mitsumori R, lhara Y: Distinct mechanisms by mutant presenilin 1 and 2 leading to increased intracellular levels of amyloid β-protein 42 in Chinese hamster ovary cells. Biochemistry 42: 1042-1052, 2003

田平　武（国立療養所中部病院・長寿医療研究センター）

1.Konagaya M, Kato T, Sakai M, Kuru S, Matsuoka Y, Konagaya Y, Hashizume Y, Tabira T: A clinical and pathological study of a Japanese case of Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex with family history. J Neurol 250: 164-70, 2003

2.Tanahashi H, Asada T, Tabira T: c954C→T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer’s disease. Ann Neurol 52: 691-693, 2002

3.Tanahashi H, Tabira T: Characterization of an amyloid precursor protein (APP)-binding protein Fe65L2 and its two novel isoforms lacking phosphotyrosine interaction
domain. Biochem J 367: 687-695, 2002

4.Tabira T, Chui DH, Nakayama H, Kuroda S, Shibuya M: Alzheimer’s disease with spastic paresis and cotton wool type plaques. J Neurosci Res 70: 367-372, 2002

柳澤勝彦（国立療養所中部病院・長寿医療研究センター）

1.Gong JS, Kobayashi M, Hayashi H, Zou K, Sawamura N, Fujita SC, Yanagisawa K, Michikawa M: Apolipoprotein E (apoE) isoform-dependent lipid release from astrocytes prepared from human-apoE3- and apoE4-knock-in mice. J Biol Chem 277: 29919-29926, 2002

2.Komano H, Shiraishi H, Kawamura Y, Sai X, Suzuki R, Serneels L, Kawaichi M, Kitamura T, Yanagisawa K: A new functional screening system for identification of regulators for the generation of amyloid β-protein. J Biol Chem 277: 39627-39633, 2002

3.Zou K, Gong JS, Yanagisawa K, Michikawa M: A novel function of monomeric amyloid β-protein serving as an antioxidant molecule against metal-induced oxidative damage. J Neurosci 22: 4833-4841, 2002

4.Kakio A, Nishimoto S, Yanagisawa K, Kozutsumi Y, Matsuzaki K: Interactions of amyloid β-protein with various gangliosides in raft like membranes: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 23: 7385-7390, 2002

5.Fan QW, Yu W, Gong JS, Zou K, Sawamura N, Senda T, Yanagisawa K, Michikawa M: Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons. J Neurochem 80: 178-190, 2002

6.Gong JS, Sawamura N, Zou K, Sakai J, Yanagisawa K, Michikawa M: Amyloid β-protein affects cholesterol metabolism in cultured neurons: Implications for pivotal role of cholesterol in the amyloid cascade. J Neurosci Res 70: 438-446, 2002

7.Watarai M, Makino S, Michikawa M, Yanagaisawa K, Murakami S, Shirahata T: Macrophage plasma membrane cholesterol contributes Brucella abortus infection of mice. Infect Immun 70: 4818-4825, 2002

8.Sawamura N, Gong JS, Chang TY, Yanagisawa K, Michikawa M: Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane domains in Niemann-Pick C1-deficient cells. J Neurochem in press

石浦章一（東京大学・大学院総合文化研究科）

1.Suo S, Sasagawa N, Ishiura S: Identification of a dopamine receptor from Caenohabditis elegans. Neurosci Lett 319: 13-16, 2002

2.Suzuki T, Nakagawa M, Yoshikawa A, Sasagawa N, Yoshimori T, Ohsumi Y, Nishsino I, Ishiura S, Nonaka I: The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathy. J Biochem 131: 647-651, 2002

3.Hotoda N, Koike H, Sasagawa N, Ishiura S: A secreted form of ADAM9 has an α-secretase activity for APP. Biochem Biophys Res Commun 293: 800-805, 2002

4.Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Mariyama K, Ishiura S: BACE1 interacts with nicastrin. Biochem Biophys Res Commun 293: 1228-1232, 2002

5.Asai M, Hattori C, Szabo B, Sasagawa N, Maruyama K, Tanuma S, Ishiura, S: Putative function of ADAM9, ADAM10, and ADAM17 as APP α-secretase. Biochem Biophys Res Commun 301: 231-235, 2003

6.Kino Y, Oma Y, Takeshita Y, Takahashi N, Sasagawa N, Ishiura S: Direct evidence that EXP/muscleblind interacts with CCUG tetranucleotide repeats. Basic Appl Myol in press

7.Takeshita Y, Sasagawa N, Usuki F, Ishiura S: Decreased expression of α-B-crystallin in C2C12 cells that express human DMPK/160CTG repeats. Basic Appl Myol in press

高島明彦（理化学研究所・脳科学総合研究センター）

1.Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Frautschy SA, Takashima A: Intracellular Aβ is increased by okadaic acid exposure in the transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2002

2.Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H, Takashima A: Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 15: 61-64, 2002

3.Tanemura K, Akagi T, Murayama M, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A: Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002

4.Sato S, Tatebayashi Y, Akagi T, Chui DH, Murayama M, Miyasaka T, Planel E, Tanemura K, Sun X, Hashikawa T, Yoshioka K, Ishiguro K, Takashima A: Aberrant tau phosphorylation by GSK-3β and JNK-3 induces oligomeric tau fibrils in COS-7 cells. J Biol Chem 277: 42060-42065, 2002

5.Tatebayashi Y, Miyasaka T, Chui DH, Akagi T, Mishima K, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A: Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci USA 99: 13896-13901, 2002

6.Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H: Nordihydroguaiaretic acid potently breaks down pre-formed Alzheimer's β-amyloid fibrils in vitro. J Neurochem 81: 434-440, 2002

7.Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H: The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin- independent mechanisms. Proc Natl Acad Sci USA 99: 8760-8765 ,2002

8.Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H: Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci USA 100: 721-726, 2003

9.Kwok JBJ, Halliday GM, Brook WS, Dolios G, Laudon H, Murayama O, Hallupp M, Badenhop RF, Vick J, Eang R, Naslund J, Takashima A, Gandy SE, Schofield PR: Presenilin-1 mutation (Leu271Val) results in altered exonic splicing and Alzheimer’s disease with non-cored plaques and neuritic dystrophy. J Biol Chem in press

西道隆臣（理化学研究所・脳科学総合研究センター）

1.Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, St. George-Hyslop P, Saido TC: Aβ-degrading endopeptidase, neprilysin, in mouse brain: Synaptic and axonal localization inversely correlating with Aβ pathology. Neurosci Res 43: 39-56, 2002

2.Shirotani K, Tsubuki S, Lee H-J, Maruyama K, Saido TC: Generation of amyloid β peptide with pyroglutamate at position 3 in primary cortical neurons. Neurosci Lett 327: 25-28, 2002

3.Fukami S, Iwata N, Saido TC: Therapeutic strategies of Alzheimer’s disease through manipulation of Aβ metabolism: a focus on Aβ-degrading enzyme, neprilysin. Drug Develop Res 56: 171-183, 2002

4.Takahashi M, Fukami S, Iwata N, Inoue K, Itohara S, Itoh H, Haraoka J, Saido, TC: In vivo glioma growth requires host-derived matrix metalloproteinase 2 for maintenance of angioarchitecture. Pharmacol Res 46: 155-163, 2002

5.Iwata N, Takaki Y, Fukami S, Tsubuki S, Saido TC: Region-specific reduction of Aβ-degrading endopeptidase, neprilysin, in mouse hippocampus upon aging. J Neurosci Res 70: 493-500, 2002

6.Hattori C, Asai M, Oma Y, Kino Y, Sasagawa N, Saido TC, Maruyama K, Ishiura S: BACE1 interacts with nicastrin. Biochem Biophys Res Commun 293: 1228-1232, 2002

7.Mori C, Spooner ET, Wisniewski KE, Wisniewski TM, Yamaguchi H, Saido TC, Tolan DR, Selkoe DJ, Lemere CA: Intraneuronal Aβ42 accumulation in Down syndrome brain. Amyloid 9: 88-102, 2002

8.Kuwano K, Nisimura I, Uetsuki T, Saido TC, Yoshikawa K: Activation of calpain in cultured neurons overexpressing Alzheimer amyloid precursor protein. Mol Brain Res 107: 166-175, 2002

9.Tomioka M, Shirotani K, Iwata N, Lee H-J, Yang F, Cole GM, Seyama Y, Saido TC: In vivo role of caspases in excitotoxic neuronal death: generation and analysis of transgenic mice expressing baculoviral caspase inhibitor, p35, in postnatal neurons. Mol Brain Res 108: 18-32, 2002

10.Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido TC, Hashimoto Y: Characterization of α2,6-sialyltransferase cleavage by Alzheimer’s β-secretase (BACE1). J Biol Chem in press

11.Kitazume S, Saido TC, Hashimoto Y: Alzheimer’s β-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconjugate J in press

12.Tsubuki S, Takaki Y, Saido TC: Dutch, Flemish, Italian, and Arctic mutations of APP render Aβ more resistant to physiologically relevant proteolytic degradation. Lancet in press

西村正樹（滋賀医科大学・分子神経科学研究センター）

1.Rozmahel R, Huang J, Chen F, Liang Y, Nguyen V, Ikeda M, Levesque G, Yu G, Nishimura M, Mathews P, Schmidt SD, Mercken M, Bergeron C, Westaway D, St George-Hyslop P: Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of β-APP. Neurobiol Aging 23: 187-194, 2002

森　啓（大阪市立大学・大学院医学研究科）

1.Ishii K, Klunk WE, Arawaka S, Debnath ML, Furiya Y, Sahara N, Shoji S, Tamaoka A, Pettegrew A, Mori H: Chrysamine G and its derivative reduce amyloid β-induced neurotoxicity in mice. Neurosci Lett 333: 5-8, 2002

2.Busciglio J, Pelsman A, Wong C, Pigino G, Yuan M, Mori H, Yankner BA: Altered metabolism of the amyloid precursor protein is associated with mitochondrial dysfunction in Down's syndrome. Neuron 33: 677-688, 2002

3.Yuasa S, Nakajima M, Aizawa H, Sahara N, Koizumi K, Sakai T, Usami M, Kobayashi S, Kuroyanagi H, Mori H, Koseki H, Shirasawa T: Impaired cell cycle control of neuronal precursor cells in the neocortical primordium of presenilin-1-deficient mice. J Neurosci Res 70: 501-513, 2002

4.Takuma H, Arawaka S, Mori H: Isoform changes of tau protein during development in various species. Dev Brain Res in press

植田　正（九州大学・大学院薬学研究院）

1.Ueda T, Nagata M, Monji A, Yoshida I, Tashiro N, Imoto T: Effect of sucrose on formationof the β-amyloid fibrils and D-aspartic acids in Aβ 1-42. Biol Pharm Bull 25: 375-378, 2002

2.Klein-Seetharaman J, Oikawa M, Grimshaw SB, Wirmer J, Durchardt E, Ueda T, Imoto T, Smith LJ, Dobson CM, Schwalbe H: Long-range interactions within a nonnative protein. Science 295: 1719-1722, 2002

3.Nishida S, Fujimitsu K, Sekimizu K, Ohmura T, Ueda T, Katayama T: A nucleotide switch in the E. coli DnaA protein initiates chromosomal replication: Evidence from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo. J Biol Chem 277: 14986-14995, 2002

4.Ohmura T, Motoshima H, Ueda T, Imoto T: Fluctuations in free or substrate-complexed lysozyme and a mutant of it detected on x-ray crystallography and comparison with those detected on NMR. J Biochem 131: 701-704, 2002

5.Ohkuri T, Ueda T, Yoshida Y, Abe Y, Hamasaki N, Imoto T: A metal binding in the polypeptide chain improves the folding efficiency of a denatured and reduced protein. Biopolymers 64: 106-114, 2002

6.Masumoto K, Ueda T, Nagata M, Yamada Y, Yoshida Y, Hashimoto Y, Imoto T: Effects of stereochemistry of sugars on protein stabilities. Protein Pept Lett 9: 435-439, 2002

7.Obita T, Iwura T, Su'etsugu M, Yoshida Y, Tanaka Y, Kayatama T, Ueda T, Imoto T: Determination of the secondary structure in solution of the Escherichia coli DnaA DNA-binding domain. Biochem Biophys Res Commun 299: 42-48, 2002

8.Tsujihata Y, Mizukami Y, Ueda T, So T, Imoto T: B-cell repertoire specific for an unfolded self-determinant of mouse lysozyme escape tolerance and dominantly participate in the autoantibody response. Immunology 107: 394-402, 2002

9.Obita T, Ueda T, Imoto T: Solution structure and activity of mouse lysozyme M. Cell Mol Life Sci 60: 176-184, 2003

大河内正康（大阪大学・大学院医学系研究科）

1.Okochi M, Steiner H, Fukumori A, Tanii H, Tomita T, Tanaka T, Iwatsubo T, Kudo T, Takeda M, Haass C: Presenilins mediate a dual intramembranous γ-secretase cleavage of Notch-1. EMBO J 21: 5408-5416, 2002

2.Lammich S, Okochi M, Takeda M, Kaether C, Capell A, Zimmer AK, Edbauer D, Walter J, Steiner H, Haass C: Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide. J Biol Chem 277: 44754-44759, 2002

3.Fluhrer R, Multhaup G, Schlicksupp A, Okochi M, Takeda M, Lammich S, Willem M, Westmeyer G, Bode W, Walter J, Haass C: Identification of a β-secretae activity, which truncates amyloid β-peptide after Its presenilin-dependent generation. J Biol Chem 278: 5531-5538, 2003

小野正博（長崎大学・大学院医歯薬学総合研究科）

1.Ono M, Kung MP, Hou C, Kung HF: Benzofuran derivatives as Aβ-aggregates-specific imaging agents for Alzheimer’s disease. Nucl Med Biol 29: 633-642, 2002

加藤兼房（愛知県心身障害者コロニー・発達障害研究所）

1.Tanabe K, Kozawa O, Niwa M, Yamomoto T, Matsuno H, Ito H, Kato K, Dohi S, Uematsu T: Contrasting effects of midazolam on induction of heat shock protein 27 by vasopressin and heat in aortic smooth muscle cells. J Cell Biochem 84: 39-46, 2002

2.Hatakeyama D, Kozawa O, Niwa M, Matsuno H, Ito H, Kato K, Tatematsu N, Shibata T, Uematsu T: Upregulation by retinoic acid of transforming growth factor-β-stimulated heat shock proten 27 induction in osteoblasts: involvement of mitogen-activated protein kinases. Biochim Biophys Acta 1589: 15-30, 2002

3.Tokuda H, Kozawa O, Niwa M, Matsuno H, Kato K, Uematsu T: Mechanism of prostagrandin E2-stimulated heat shock protein 27 induction in osteoblast-like MC3T3-E1 cells. Endocrinology 172: 271-281, 2002

4.Ito H, Kamei K, Iwamoto I, Inaguma Y, Galcia-Mata R, Sztul E, Kato K: Inhibition of proteasomes induces accumulation, phosphorylation and recruitment of HSP27 and αB-crystallin to aggresomes. J Biochem 131: 593-603, 2002

5.Wang H, Ichihara G, Ito H, Kato K, Kitoh J, Yamada T, Yu X, Tsuboi S, Moriyama Y, Sakatani R, Kamijima M, Itohara S, Takeuchi Y: Biochemical changes in the central nervous system of rats exposed to 1-bromopropane for seven days. Toxicol Sci 67: 114-120, 2002

6.Yamauchi S, Tokita Y, Aono S, Matsui F, Shuo T, Ito H, Kato K, Kasahara K, Oohira A: Phosphorylation of neuroglycan C, a brain-specific transmembrane chondroitin sulfate proteoglycan, and its localization in the lipid rafts. J Biol Chem 277: 20583-20590, 2002

7.Hirade K, Kozawa O, Tanabe K, Niwa M, Matsuno H, Oiso Y, Akamatsu S, Ito H, Kato K, Katagiri Y, Uematsu T: Thrombin stimulates dissocoation and induction of HSP27 via p38 MAPK in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 283: H941-H948, 2002

8.Katoh-Semba R, Asano T, Ueda H, Morishita R, Takeuchi I K, Inaguma Y, Kato K: Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J 16: 1328-1330, 2002

9.Kato K, Ito H, Kamei K, Iwamoto I, Inaguma Y: Innervation-dependent phosphorylation and accumulation of αB-crystallin and Hsp27 as insoluble complexes in disused muscle. FASEB J 16: 1432-1434, 2002

10.Kozawa O, Niwa M, Hatakeyama D, Tokuda H, Oiso Y, Matsuno H, Kato K, Uematsu T: Specific induction of heat shock protein 27 by glucocorticoid in osteoblasts. J Cell Biochem 86: 357-364, 2002

木曽良明（京都薬科大学・薬学部）

1.Ami E, Rajesh S, Wang J, Kimura T, Hayashi Y, Kiso Y, Ishida T: Synthesis of novel amino acid, L-bis-tetrahydrofuranylglycines. Tetrahedron Lett 43: 2931-2934, 2002

2.Hamada Y, Ohtake J, Sohma Y, Kimura T, Hayashi Y, Kiso Y: New water-soluble prodrugs of HIV protease inhibitors based on ON intramolecular acyl migration. Bioorg Med Chem 10: 4155-4167, 2002

3.Rajesh S, Ami E, Kotake T, Kimura T, Hayashi Y, Kiso Y: An expedient synthesis of N^α-protected-L-tetrahydrofuranylglycine and its application in the synthesis of novel substrate based inhibitors of HIV-1 protease. Bioorg Med Chem Lett 12: 3615-3617, 2002

4.Hidaka K, Kimura T, Hayashi Y, McDaniel KF, Dekhtyar T, Colletti L, Kiso Y: Design and synthesis of pseudo-symmetric HIV protease inhibitors containing a novel hydroxymethylcarbonyl (HMC)-hydrazide isostere. Bioorg Med Chem Lett 13: 93-96, 2003

三枝弘尚（東京医科歯科大学・大学院医歯学総合研究科）

1.Sakata Y, Saegusa H, Zong S, Osanai M, Murakoshi T, Shimizu Y, Noda T, Aso T, Tanabe T: Ca_v2.3 (α_1E) Ca²⁺ channel participates in the control of sperm function. FEBS Lett 516: 229-233, 2002

2.Han W, Saegusa H, Zong S, Tanabe T: Altered cocaine effects in mice lacking Ca_v2.3 (α_1E) calcium channel. Biochem Biophys Res Commun 299: 299-304, 2002

3.Takei T, Saegusa H, Zong S, Murakoshi T, Makita K, Tanabe T: Anesthetic sensitivities to propofol and halothane in mice lacking the R-type (Ca_v2.3) Ca²⁺ channel. Anesth Analg in press

辛　龍雲（東北大学・大学院医学系研究科）

1.Yamamoto A, Shin R-W, Hasegawa K, Naiki H, Sato H, Yoshimasu Y, Kitamoto T: Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer’s disease. J Neurochem 82: 1137-1147, 2002

2.Kitamoto T, Mohri S, Ironside JW, Miyoshi I, Tanaka T, Kitamoto N, Itohara S, Kasai N, Katuski M, Higuchi J, Muramoto T, Shin R-W: Follicular dendritic cell of the knock-in mouse provides a new bioassay for human prions. Biochem Biophys Res Commun 294: 280-286, 2002

3.Kuazi DA, Kito K, Abe Y, Shin R-W, Kamitani T, Ueda N: NEDD8 involvement in the ubiquitinated inclusion bodies. J Pathol 199: 259-266, 2003

4.Shin RW, Kruck TP, Murayama H, Kitamoto T: A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimer’s disease. Brain Res 961: 139-146, 2003

鈴木利治（北海道大学・大学院薬学研究科）

1.Hase M, Yagi Y, Taru H, Tomita S, Sumioka A, Hori K, Miyamoto K, Sasamura T, Nakamura M, Matsuno K, Suzuki T: Expression and characterization of the Drosophila X11-like/Mint protein during neural development. J Neurochem 81: 1223-1232, 2002

2.Taru H, Iijima K, Hase M, Kirino Y, Yagi Y, Suzuki T: Interaction of APP family protein with scaffold proteins of the JNK signaling cascade. J Biol Chem 277: 20070-20078, 2002

3.Taru H, Kirino Y, Suzuki T: Differential roles of JIP scaffold proteins in the modulation of amyloid precursor protein metabolism. J Biol Chem 277: 27567-27574, 2002

4.Ishii J, Adachi H, Aoki J, Koizumi H, Tomita S, Suzuki T, Tsujimoto M, Inoue K, Arai H: SREC-II, a new member of the scavenger receptor type F family, trans-interacts with SREC-I through its extracellular domain. J Biol Chem 277: 39696-39702, 2002

住本英樹（九州大学・生体防御医学研究所）

1.Yamamori T, Inanami O, Sumimoto H, Akasaki T, Nagahata H, Kuwabara M: Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils. Biochem Biophys Res Commun 293: 1571-1578, 2002

2.Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H: PAR3β, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions. Biochem Biophys Res Commun 299: 641-646, 2002

3.Kubo T, Yamashita T, Yamaguchi A, Sumimoto H, Hosokawa K, Tohyama M: A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling. J Neurosci 22: 8504-8513, 2002

4.Kami K, Takeya R, Sumimoto H, Kohda D: Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67^phox, Grb2 and Pex13p. EMBO J 21: 4268-4276, 2002

5.Kuribayashi F, Nunoi H, Wakamatsu K, Tsunawaki S, Sato K, Ito T, Sumimoto H: The adaptor protein p40^phox as a positive regulator of the superoxide-producing phagocyte oxidase. EMBO J 21: 6312-6320, 2002

6.Ago T, Kuribayashi F, Hiroaki H, Takeya R, Ito T, Kohda D, Sumimoto H: Phosphorylation of p47^phox directs PX domain from SH3 domain towards phosphoinositides, leading to activation of the phagocyte NADPH oxidase. Proc Natl Acad Sci USA in press

竹島　浩（東北大学・大学院医学系研究科）

1.Yamazaki T, Takeda K, Gotoh K, Takeshima H, Akira S, Kurosaki T: Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med 195: 535-545, 2002

2.Higgins GA, Kew JN, Richards JG, Takeshima H, Jenck F, Adam G, Wichmann J, Kemp JA, Grottick AJ: A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory. Eur J Neurosci 15: 911-922, 2002

3.Nishi M, Hashimoto K, Kuriyama K, Komazaki S, Kano M, Shibata S, Takeshima H: Motor discoordination in mutant mice lacking junctophilin type 3. Biochem Biophys Res Commun 292: 318-324, 2002

4.Uehara A, Yasukochi M, Imanaga I, Nishi M, Takeshima H: Store-operated Ca²⁺ entry irrelevant to Ca²⁺ release channel and junctional membrane complex in heart muscle cells. Cell Calcium 31: 89-96, 2002

5.Pan Z, Yang D, Nagaraj RY, Nosek TA, Nishi M, Takeshima H, Cheng H, Ma J: Dysfunction of store-operated Ca²⁺ channel in muscle cells lacking mg29 gene. Nat Cell Biol 4: 379-383, 2002

6.Komazaki S, Ito K, Takeshima H, Nakamura H: Deficiency of triad formation in developing skeletal muscle cells lacking junctophilin type 1. FEBS Lett 524: 225-229, 2002

7.Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M: Delta/Notch-like EGF-related receptor (DNER), a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. J Biol Chem 277: 25400-25407, 2002

8.Houtani T, Ikeda M, Kase M, Sato K, Sakuma S, Kakimoto S, Ueyama T, Munemoto Y, Takeshima H, Sugimoto T: A subset of nociceptin/orphanin FQ receptor-expressing neurons in the anterior hypothalamic area, as revealed in mice with lacZ reporter gene. Neurosci Lett 335: 217-219, 2003

9.Inoue M, Kawashima T, Takeshima H, Calo G, Inoue A, Nakata Y, Ueda H: In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord. J Pharmacol Exp Ther in press

10.Komazaki S, Nishi M, Takeshima H: Abnormal junctional membrane structures in cardiac myocytes expressing ectopic junctophilin type 1. FEBS Lett in press

玉村啓和（京都大学・大学院薬学研究科）

1.Tamamura H, Hori T, Otaka A, Fujii N: Efficient stereoselective synthesis of peptidomimetics containing hydroxyethylamine dipeptide isosteres utilizing the aza-Payne rearrangement and O, N-acyl transfer reactions. J Chem Soc, Perkin Trans 1 2002: 577-580, 2002

2.Oishi S, Kamano T, Niida A, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N: Diastereoselective synthesis of y[(E)-CH=CMe]- and y[(Z)-CH=CMe]-type dipeptide isosteres by organocopper-mediated anti-S_N2' reaction. Org Lett 4: 1051-1054, 2002

3.Oishi S, Niida A, Kamano T, Odagaki Y, Tamamura H, Otaka A, Hamanaka N, Fujii N: Diastereoselective synthesis of y[(E)-CMe=CH]- and y[(E)-CMe=CMe]-type dipeptide isosteres based on organocopper-mediated anti-S_N2' reaction. Org Lett 4: 1055-1058, 2002

4.Oishi S, Niida A, Kamano T, Miwa Y, Taga T, Odagaki Y, Hamanaka N, Yamamoto M, Ajito K, Tamamura H, Otaka A, Fujii N: Regio- and stereoselective ring-opening of chiral 1,3-oxazolidin-2-one derivatives by organocopper reagents provides novel access to di-, tri- and tetra-substituted alkene dipeptide isosteres. J Chem Soc, Perkin Trans 1 2002: 1786-1793, 2002

5.Otaka A, Katagiri F, Kinoshita T, Odagaki Y, Oishi S, Tamamura H, Hamanaka N, Fujii N: Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-S_N2' reactions. J Org Chem 67: 6152-6161, 2002

6.Oishi S, Kamano T, Niida A, Odagaki Y, Hamanaka N, Yamamoto M, Ajito K, Tamamura H, Otaka A, Fujii N: Diastereoselective synthesis of new Ψ[[(E)-CH=CMe]- and Ψ[[(Z)-CH=CMe]-type alkene dipeptide isosteres by organocopper reagents and application to conformationally restricted cyclic RGD peptidomimetics. J Org Chem 67: 6162-6173, 2002

7.Tamamura H, Koh Y, Ueda S, Sasaki Y, Yamasaki T, Aoki M, Maeda K, Watai Y, Arikuni H, Otaka A, Mitsuya H, Fujii N: Reduction of peptide character of HIV protease inhibitors that exhibit nanomolar potency against multi-drug resistant HIV-1 strains. J Med Chem in press

出澤真里（京都大学・大学院医学研究科）

1.Oshitari T, Dezawa M, Okada S, Takano M, Negishi h, Horie H, Sawada H, Tokuhisa T, Adachi-Usami E: The role of c-fos in cell death and regeneration of retinal ganglion cells. Invest Ophthalmol Vis Sci 43: 2442-2449, 2002

2.Mo X, Yokoyama A, Oshitari T, Negishi H, Dezawa M, Mizota A, Adachi-Usami E: Rescue of axotomized retinal ganglion cells by BDNF gene electroporation in adult rats. Invest Ophthalmol Vis Sci 43: 2401-2405, 2002

3.Dezawa M, Takano M, Negishi H, Mo X, Oshitari T, Sawada H: Gene transfer into retinal ganglion cells by in vivo electroporation: A new approach. Micron 33: 1-6, 2002

4.Yamazaki H, Ohguro H. Maeda T, Maruyama I, Takano Y, Metoki T, Nakazawa M, Sawada H, Dezawa M: Nilvadipine, a Ca²⁺ antagonist, effectively preserves retinal morphology and functions in Royal College Surgeons rat. Invest Ophthalmol Vis Sci 43: 919-26, 2002

5.Takano M, Horie H, Iijima Y, Dezawa M, Sawada H, Ishikawa Y: Brain-derived neurotrophic factor enhances neurite regeneration from retinal ganglion cells in aged human retina in vitro. Exp Eye Res 74: 319-323, 2002

内木宏延（福井医科大学・医学部）

1.Ono K, Hasegawa K, Yoshiike Y, Takashima A, Yamada M, Naiki H: Nordihydroguaiaretic acid potently breaks down preformed Alzheimer’s β-amyloid fibrils in vitro. J Neurochem 81: 434-440, 2002

2.Martsev SP, Dubnovitsky AP, Vlasov AP, Hoshino M, Hasegawa K, Naiki H, Goto Y: Amyloid fibril formation of mouse VL domain under acidic pH. Biochemistry 41: 3389-3395, 2002

3.Hoshino M, Katou H, Hagihara Y, Hasegawa K, Naiki H, Goto Y: Mapping the core of the b₂-microglobulin amyloid fibril by H/D exchange. Nat Struct Biol 9: 332-336, 2002

4.Hong D, Gozu M, Hasegawa K, Naiki H, Goto Y: Conformation of b₂-microglobulin amyloid fibrils analyzed by reduction of the disulfide bond. J Biol Chem 277: 21554-21560, 2002

5.Ono K, Hasegawa K, Yamada M, Naiki H: Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro. Biol Psychiat 52: 880-886, 2002

6.Kamataki A, Takahashi S, Masamura K, Iwasaki T, Hattori H, Naiki H, Yamada K, Suzuki J, Miyamori I, Sakai J, Fujino T, Yamamoto T: Remnant lipoprotein particles are taken up into myocardium through VLDL receptor: a possible mechanism for cardiac fatty acid metabolism. Biochem Biophys Res Commun 293: 1007-1013, 2002

7.Katou H, Kanno T, Hoshino M, Hagihara Y, Tanaka H, Kawai T, Hasegawa K, Naiki H, Goto Y: The role of disulfide bond in the amyloidogenic state of β2-microglobulin studied by heteronuclear NMR. Protein Sci 11: 2218-2229, 2002

8.Takahashi N, Hasegawa K, Yamaguchi I, Okada H, Ueda T, Gejyo F, Naiki H: Establishment of a first-order kinetic model of light chain-associated amyloid fibril extension in vitro. Biochim Biophys Acta 1601: 110-120, 2002

9.Hasegawa K, Ono K, Yamada M, Naiki H: Kinetic modeling and determination of reaction constants of Alzheimer's β-amyloid fibril extension and dissociation using surface plasmon resonance. Biochemistry 41: 13489-13498, 2002

10.Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F, Kitamoto T: Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease. J Neurochem 82: 1137-1147, 2002

11.Mori I, Liu B, Hossain MJ, Takakuwa H, Daikoku T, Nishiyama Y, Naiki H, Matsumoto K, Yokochi T, Kimura Y: Successful protection by amantadine hydrochloride against lethal encephalitis caused by a highly neurovirulent recombinant influenza A virus in mice. Virology 303: 287-296, 2002

橋本康弘（理化学研究所・フロンティア・糖鎖機能研究チーム）

1.Nakamura K, Yamaji T, Crocker PR, Suzuki A, Hashimoto Y: Lymph node microphages, but not spleen macrophages, express high levels of unmasked sialoadhesin: Implication for the adhesive properties of macrophages in vivo. Glycobiology 12: 1-8, 2002

2.Yamaji T, Teranishi T, Alphey MS, Crocker PR, Hashimoto Y: A small region of the natural killer cell receptor, Siglec-7, is responsible for the unique specificity for α2,8disialyl and branched α2,6sialyl residues: a comparison with Siglec-9. J Biol Chem 277: 6324-6332, 2002

3.Takahashi H, Hirai Y, Migita M, Seino Y, Fukuda Y, Sakuraba H, Kase R, Kobayashi T, Hashimoto Y, Shimada T: Long-term systemic therapy of Fabry disease in a knockout mouse by adeno-associated virus-mediated muscle-directed gene transfer. Proc Natl Acad Sci USA 99: 13777-13782, 2002

4.Kitazume S, Tachida Y, Oka R, Kotani N, Ogawa K, Suzuki M, Dohmae N, Takio K, Saido TC, Hashimoto Y: Characterization of α2,6-sialyltransferase cleavage by Alzheimer’s β-secretase (BACE1): Occurrence of a subsequent processing by aminopeptidase. J Biol Chem in press

5.Kitazume S, Saido TC, Hashimoto Y: Alzheimer's β-secretase cleaves a glycosyltransferase as a physiological substrate. Glycoconjugate J in press

長谷川成人（東京都精神医学総合研究所・分子神経生物）

1.Miake T, Mizusawa H, Iwatsubo T, Hasegawa M: Biochemical characterization of the core structure of α-synuclein filaments. J Biol Chem 277: 19213-19219, 2002

2.Kahle PJ, Neumann M, Ozmen L, Muller V, Jacobsen H, Spooren W, Fuss B, Mallon B, Macklin WB, Fujiwara H, Hasegawa M, Iwatsubo T, Kretzschmar HA, Haass C: Hyperphosphorylation and insolubility of α-synuclein in transgenic mouse oligodendrocytes. EMBO Rep 3: 583-588, 2002

3.Neumann M, Kahle PJ, Giasson BI, Ozmen L, Borroni E, Spooren W, Muller V, Odoy S, Fujiwara H, Hasegawa M, Iwatsubo T, Trojanowski JQ, Kretzschmar HA, Haass C: Misfolded proteinase K-resistant and hyperphosphorylated α-synuclein in aged transgenic mice with locomotor deterioration and in human α-synucleinopathies. J Clin Invest 110: 1429-1439, 2002

4.Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann D, Iwatsubo T: Phosphorylated α-synuclein is ubiquitinated in α-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002

5.Kowalska A, Hasegawa M, Miyamoto K, Akiguchi I, Ikemoto A, Takahashi K, Araki W, Tabira T: A novel mutation at position +11 in the intron following exon 10 of the tau gene in FTDP-17. J Appl Genet 43: 535-543, 2002

6.Kobayashi T, Ota S, Tanaka K, Ito Y, Hasegawa M, Umeda Y, Motoi Y, Takanashi M, Yasuhara M, Anno M, Mizuno Y, Mori H: A novel L266V mutation of the tau gene causes frontotemporal dementia with a unique tau pathology. Ann Neurol 53: 133-137, 2003

7.Takahashi M, KanukaH, Fujiwara H, Hasegawa M, Miura M, Iwatsubo T: Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic Drosophila. Neurosci Lett 336: 155-158, 2003

8.Saito Y, Kawashima A, Ruberu NN, Fujiwara H, Koyama S, Sawabe M, Arai T, Nagura H, Yamanouchi H, Hasegawa M, Iwatsubo T, Murayama S: Accumulation of phosphorylated α-synuclein in aging human brain. J Neuropathol Exp Neurol in press

9.Taniguchi S, McDonagh AM, Pickering-Brown SA, Umeda Y, Iwatsubo T, Hasegawa M, Mann DMA: The neuropathology of frontotemporal lobar degeneration with respect to the cytological and biochemical characteristics of tau protein. Neuropathol Appl Neurobiol in press

10.Arai T, Nonaka T, Hasegawa M, Akiyama H, Yoshida M, Hashizume Y, Tsuchiya K, Oda T, Ikeda K: Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62. Neurosci Lett in press

原田彰宏（群馬大学・生体調節研究所）

1.Harada A, Teng J, Takei Y, Oguchi K, Hirokawa N: MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J Cell Biol 158: 541-549, 2002

2.Sato T, Sato-Harada R, Takano M, Kato S, Saburi S, Harada A: Localization of cAMP-dependent protein kinase in the actin and microtubule cytoskeletons in mouse hippocampal neurons. Neurosci Lett 325: 83-86, 2002

藤野貴広（東北大学・遺伝子実験施設）

1.Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT: Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion. Proc Natl Acad Sci USA 100: 229-234, 2003

2.Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT: Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1. J Biol Chem 278: 7344-7349, 2003

3.Magoori K, Kang MJ, Iwasaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT: Severe hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E. J Biol Chem in press

松崎勝巳（京都大学・大学院生命科学研究科）

1.Kakio A, Nishimoto A, Yanagisawa K, Kozutsumi Y, Matsuzaki K: Interactions of amyloid β-protein with various gangliosides in raft-like membranes: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid. Biochemistry 41: 7385-7390, 2002

2.Tachi T, Epand RF, Epand RM, Matsuzaki K: Position-dependent hydrophobicity of the antimicrobial magainin peptide affects the mode of peptide-lipid interactions and selective toxicity. Biochemistry 41: 10723-10731, 2002

3.Yano Y, Matsuzaki K: Membrane insertion and dissociation processes of a model transmembrane helix. Biochemistry 41: 12407-12413, 2002

4.Takeshima K, Chikushi A, Lee KK, Yonehara S, Matsuzaki K: Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes. J Biol Chem 278: 1310-1315, 2003

5.Kakio A, Nishimoto A, Kozutsumi Y, Matsuzaki K: Formation of a membrane-active from of amyloid β-protein in raft-like model membranes. Biochem Biophys Res Commun in press

松原悦朗（岡山大学・大学院医歯学総合研究科）

1.Shoji M, Matsubara E, Murakami T, Manabe Y, Abe K, Kanai M, Ikeda M, Tomidokoro Y, Shizuka M, Watanabe M, Amari M, Ishiguro K, Kawarabayashi T, Harigaya Y, Okamoto K, Nishimura T, Nakamura Y, Takeda M, Urakami K, Adachi Y, Nakashima K, Arai H, Sasaki H, Kanemaru K, Yamanouchi H, Yoshida Y, Ichise K, Tanaka K, Hamamoto M, Yamamoto H, Matsubayashi T, Yoshida H, Toji H, Nakamura S, Hirai S: Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study group. Neurobiol Aging 23: 363-370, 2002

2.Shizuka-Ikeda M, Matsubara E, Ikeda M, Kanai M, Tomidokoro Y, Ikeda Y, Watanabe M, Kawarabayashi T, Harigaya Y, Okamoto K, Maruyama K, Castano EM, St George-Hyslop P, Shoji M: Generation of amyloid β protein from a presenilin-1 and βAPP complex. Biochem Biophys Res Commun 292: 571-578, 2002

3.Shoji M, Fukushima K, Wakayama M, Shizuka-Ikeda M, Ikeda Y, Kawakami A, Sakazume Y, Ikeda M, Harigaya Y, Matsubara E, Kawarabayashi T, Murakami T, Nagano I, Manabe Y, Abe K: Intellectual faculities in patients with Alzheimer’s disease regress to the level of a 4-5-year old child. Geriatr Gerontol Internat 2: 143-147, 2002

4.Sasaki A, Shoji M, Harigaya Y, Kawarabayashi T, Ikeda M, Naito M, Matsubara E, Abe K, Nakazato Y: Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neurites. Virchows Arch 441: 358-367, 2002

5.Prat MI, Adamo AM, Gonzalez SA, Affranchino JL, Ikeda M, Matsubara E, Shoji M, Smith MA, Castano EM, Morelli L: Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein: relevance for neurodegeneration. Neurosci Lett 326: 9-12, 2002

6.Matsubara E, Bryant-Thomas T, Pacheco J, Henry TL, Poeggeler B, Manjon M, Herbert D, Cruz-Sanchez F, Chyan Y-J, Shoji M, Abe K, Leone A, Grundke-Iqbal I, Wilson G, Ghiso J, Williams C, Refolo LM, Pappolla MA: Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer’s disease. J Neurochem in press

水口峰之（富山医科薬科大学・薬学部）

1.Miura K, Kamimura M, Aizawa T, Kiuchi M, Hayakawa Y, Mizuguchi M, Kawano K: Solution structure of paralytic peptide of silkworm, Bombyx mori. Peptide 23: 2111-2116, 2002

2.Tada M, Kobashigawa Y, Mizuguchi M, Miura K, Kouno T, Kumaki Y, Demura M, Nitta K, Kawano K: Stabilization of protein by replacement of a fluctuating loop: structural analysis of a chimera of bovine α-lactalbumin and equine lysozyme. Biochemistry 41: 13807-13813, 2002

3.Mizuguchi M,Kobashigawa Y, Kumaki Y, Demura M, Kawano K, Nitta K: Effects of a helix substitution on the folding mechanism of bovine α-lactalbumin. Proteins 49: 95-103, 2002 

4.Matsubara K, Mizuguchi M, Kawano K: Expression of a synthetic gene encoding human transthyretin in Escherichia coli. Protein Express Purif in press

5.Tada M, Aizawa T, Shinohara Y, Matsubara K, Miura K, Yoshida M, Shitara K, Kouno T, Mizuguchi M, Nitta K, Hayakawa Y, Kawano K: Role of aromatic residues in the structure and biological activity of the small cytokine, growth-blocking peptide (GBP). J Biol Chem in press

山口晴保（群馬大学・医学部保健学科）

1.Sun X, Cole GM, Chu T, Xia W, Galasko D, Yamaguchi H, Tanemura K, Frautschy A, Takashima A: Intracellular Aβ is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol Aging 23: 195-203, 2002

2.Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H: Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid β-protein. J Biol Chem 277: 12915-12920, 2002

3.Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A: Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22: 133-141, 2002

4.Sun X, Sato S, Murayama O, Murayama M, Park JM, Yamaguchi H, Takashima A: Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neurosci Lett 321: 61-64, 2002

5.Thal DR, Ghebremedhin E, Rub U, Yamaguchi H, Tredici KD, Braak H: Two types of sporadic cerebral amyloid angiopathy. J Neuropathol Exp Neurol 61: 282-293, 2002

6.Xia X, Wang P, Sun X, Soriano S, Shum W K, Yamaguchi H, Trumbauer ME, Takashima A, Koo H, Zheng H: The aspartate-257 of presenilin 1 is indispensable for mouse development and production of β-amyloid peptides through β-catenin-independent mechanisms. Proc Natl Acad Sci USA 99: 8760-8765, 2002

7.Takahashi RH, Milner TA, Li F, Nam EE, Edgar MA, Yamaguchi H, Beal MF, Xu H, Greengard P, Gouras GK: Intraneuronal Alzheimer Aβ42 accumulates in multivesicular bodies and is associated with synaptic pathology. Am J Pathol 161: 1869-1879, 2002

8.Sasaki A, Horikoshi Y, Yokoo H, Nakazato Y, Yamaguchi H: Antiserum against human glucose transporter 5 is highly specific for microglia among cells of the mononuclear phagocyte system. Neurosci Lett 338: 17-20, 2003

9.Horikoshi Y, Sasaki A, Taguchi N, Maeda M, Tsukagoshi H, Sato K, Yamaguchi H: Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections. Acta Neuropathol 105: 157-62, 2003

10.Kokubo H, Helms J-B, Ohno-Iwashita Y, Shimada Y, Horikoshi Y, Yamaguchi H: Ultrastructural localization of flotillin-1 to cholesterol-rich membrane microdomains, rafts, in rat brain tissue. Brain Res 965: 83-90, 2003