News and Publications

New Publication

2 Jul 2020

Signal dynamics of midbrain dopamine neurons during economic decision-making in monkeys

Key Points:

  1. 1. Discovery of previously unknown mechanism in which dopamine neurons support rational decision making.
  2. 2. Activity dynamics of dopamine neurons translates "value information" of an option into a "selection command" of whether or not to select an option.
  3. 3. This conversion process was completed faster in dopamine neurons than in the frontal lobe, which was previously thought to be the center of decision making. This indicates that evolutionarily conserved midbrain dopamine neurons are an important neural base supporting rational decision making.

Science Advances (DOI:10.1126/sciadv.aba4962)

Science Advances PDF (DOI:10.1126/sciadv.aba4962)

New Publication

5 Jun 2020

HHEX promotes myeloid transformation in cooperation with mutant ASXL1

• Mutant ASXL1 and HHEX promote myeloid leukemogenesis via upregulating the expression of MYB and ETV5.
• Inhibition of the HHEX-MYB/ETV5 axis would be a promising therapeutic approach for myeloid malignancies harboring ASXL1 mutations.

→ Journal - Blood 2019 :blood.2019004613

New Publication


Transcription factor MafB in podocytes protects against the development of focal segmental glomerulosclerosis.

Main Points

• Elucidation of the mechanism that suppresses the development of chronic kidney disease.

• Existing leukemia drug can suppress worsening renal damage.

Kidney International (DOI: 10.1016/j.kint.2020.02.038)

Press Release UoT Webpage (in Japanese only)

PDF Press Release Download (in Japanese only)

New Publication


Discovery of lipids that control insulin sensitivity in the liver.

Researchers at TMRC and the University of Tsukuba piece together a complex cascade of events in the liver that could someday help to develop targeted therapies for insulin resistance. Deleting a liver enzyme lowers the health risk of sweet treats (at least in mice).

Hepatology doi:10.1002/hep.30953

Press Release Publication at UoT


Sep 3, 2019

Invitation for Joint Research in Production of Genetically Modified Mice

The Transborder Medical Research Center (TMRC) and the Life Science Animal Resource Center is calling for suitable parties who are interested in research collaborations for the production of genetically modified mice. Interested parties may refer to the “Transborder Medical Research Center (TMRC) Joint Research Application Guidelines” linked below and contact Professor Satoru Takahashi for more details.

Click for Details (PDF written in Japanese only)